locus-tag	class	description
HRR99_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HRR99_00010	COG3152	Membrane
HRR99_00025	COG0640	Transcriptional regulator
HRR99_00030	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HRR99_00035	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HRR99_00040	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HRR99_00045	COG1420	regulation of RNA biosynthetic process
HRR99_00050	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HRR99_00060	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HRR99_00065	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HRR99_00075	COG1137	ATPase activity
HRR99_00080	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
HRR99_00095	COG0776	regulation of translation
HRR99_00105	COG0116	Belongs to the methyltransferase superfamily
HRR99_00105	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HRR99_00110	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HRR99_00115	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HRR99_00120	COG4999	Histidine kinase
HRR99_00120	COG3437	response regulator, receiver
HRR99_00120	COG3850	Histidine kinase
HRR99_00120	COG2205	protein histidine kinase activity
HRR99_00130	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HRR99_00135	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
HRR99_00140	COG0728	peptidoglycan biosynthetic process
HRR99_00145	COG0180	Tryptophanyl-tRNA synthetase
HRR99_00155	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
HRR99_00160	COG1214	PFAM Peptidase M22, glycoprotease
HRR99_00180	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HRR99_00185	COG1702	phosphate starvation-inducible protein PhoH
HRR99_00190	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HRR99_00195	COG1253	flavin adenine dinucleotide binding
HRR99_00200	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HRR99_00205	COG1396	sequence-specific DNA binding
HRR99_00210	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HRR99_00215	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HRR99_00220	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HRR99_00230	COG0242	peptide deformylase activity
HRR99_00235	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HRR99_00240	COG0101	tRNA pseudouridine synthase activity
HRR99_00245	COG1393	Belongs to the ArsC family
HRR99_00260	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HRR99_00265	COG2171	N-acyltransferase activity
HRR99_00275	COG1957	nucleoside hydrolase
HRR99_00280	COG0071	Belongs to the small heat shock protein (HSP20) family
HRR99_00305	COG2188	Transcriptional regulator
HRR99_00315	COG0848	biopolymer transport protein
HRR99_00325	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
HRR99_00330	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
HRR99_00335	COG3454	Phosphonate metabolism
HRR99_00340	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
HRR99_00345	COG0588	phosphoglycerate mutase activity
HRR99_00350	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HRR99_00355	COG1132	(ABC) transporter
HRR99_00360	COG0837	glucose binding
HRR99_00365	COG1803	Methylglyoxal synthase
HRR99_00370	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
HRR99_00375	COG4166	transmembrane transport
HRR99_00380	COG4174	ABC transporter (Permease)
HRR99_00385	COG4239	(ABC) transporter, permease
HRR99_00390	COG4172	Belongs to the ABC transporter superfamily
HRR99_00395	COG0174	glutamine synthetase
HRR99_00400	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HRR99_00405	COG3265	gluconokinase activity
HRR99_00410	COG1174	glycine betaine transport
HRR99_00415	COG1125	glycine betaine transport
HRR99_00420	COG1174	glycine betaine transport
HRR99_00425	COG1732	Glycine betaine
HRR99_00435	COG1959	2 iron, 2 sulfur cluster binding
HRR99_00440	COG1840	ABC-type Fe3 transport system, periplasmic component
HRR99_00450	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HRR99_00460	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HRR99_00465	COG3618	amidohydrolase
HRR99_00470	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HRR99_00485	COG0477	Major facilitator Superfamily
HRR99_00495	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HRR99_00500	COG1845	cytochrome c oxidase, subunit III
HRR99_00505	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
HRR99_00515	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
HRR99_00520	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HRR99_00525	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HRR99_00550	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
HRR99_00560	COG2986	histidine ammonia-lyase
HRR99_00565	COG1228	amidohydrolase
HRR99_00575	COG0697	spore germination
HRR99_00580	COG1028	Short-chain dehydrogenase reductase Sdr
HRR99_00595	COG0791	NLP P60 protein
HRR99_00605	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HRR99_00610	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HRR99_00645	COG4964	Belongs to the GSP D family
HRR99_00685	COG1396	sequence-specific DNA binding
HRR99_00690	COG0481	GTPase activity
HRR99_00700	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HRR99_00705	COG0697	spore germination
HRR99_00715	COG2972	Histidine kinase
HRR99_00715	COG0840	transmembrane signaling receptor activity
HRR99_00725	COG1917	Cupin 2, conserved barrel domain protein
HRR99_00725	COG2169	Transcriptional regulator
HRR99_00730	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
HRR99_00740	COG0251	oxidation-reduction process
HRR99_00745	COG1309	transcriptional regulator
HRR99_00750	COG0488	(ABC) transporter
HRR99_00765	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HRR99_00770	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HRR99_00775	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HRR99_00785	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HRR99_00800	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HRR99_00800	COG0072	phenylalanine-tRNA ligase activity
HRR99_00815	COG0667	Aldo Keto reductase
HRR99_00830	COG4977	sequence-specific DNA binding
HRR99_00855	COG1570	exodeoxyribonuclease VII activity
HRR99_00860	COG0189	ligase activity
HRR99_00870	COG3842	ATPase activity
HRR99_00875	COG0395	ABC-type sugar transport system, permease component
HRR99_00880	COG1175	transmembrane transport
HRR99_00885	COG1653	transport
HRR99_00890	COG0792	nuclease activity
HRR99_00895	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HRR99_00905	COG3963	phosphatidate phosphatase activity
HRR99_00915	COG0284	orotidine-5'-phosphate decarboxylase activity
HRR99_00935	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HRR99_00945	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HRR99_00975	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
HRR99_00990	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HRR99_00990	COG0519	Catalyzes the synthesis of GMP from XMP
HRR99_01005	COG1393	Belongs to the ArsC family
HRR99_01010	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HRR99_01015	COG2309	aminopeptidase activity
HRR99_01025	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
HRR99_01030	COG0756	dUTP diphosphatase activity
HRR99_01040	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HRR99_01065	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HRR99_01075	COG0218	Necessary for normal cell division and for the maintenance of normal septation
HRR99_01080	COG0706	membrane insertase activity
HRR99_01085	COG0594	ribonuclease P activity
HRR99_01090	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HRR99_01095	COG2972	Histidine kinase
HRR99_01095	COG0840	transmembrane signaling receptor activity
HRR99_01100	COG1823	symporter activity
HRR99_01105	COG0110	maltose O-acetyltransferase activity
HRR99_01125	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HRR99_01130	COG0418	dihydroorotase activity
HRR99_01135	COG3938	Belongs to the proline racemase family
HRR99_01145	COG3510	cephalosporin hydroxylase
HRR99_01170	COG0166	Belongs to the GPI family
HRR99_01175	COG0318	PFAM AMP-dependent synthetase and ligase
HRR99_01180	COG3842	ATPase activity
HRR99_01185	COG1840	ABC-type Fe3 transport system, periplasmic component
HRR99_01190	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
HRR99_01205	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HRR99_01220	COG1595	DNA-templated transcription, initiation
HRR99_01225	COG3806	Anti-sigma factor
HRR99_01240	COG3254	rhamnose metabolic process
HRR99_01250	COG1172	Belongs to the binding-protein-dependent transport system permease family
HRR99_01255	COG1129	ABC transporter
HRR99_01265	COG1349	DNA-binding transcription factor activity
HRR99_01270	COG3347	Dehydrogenase
HRR99_01270	COG1028	Short-chain dehydrogenase reductase Sdr
HRR99_01280	COG4952	isomerase
HRR99_01315	COG2326	polyphosphate kinase activity
HRR99_01320	COG5002	protein histidine kinase activity
HRR99_01325	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HRR99_01330	COG0573	inorganic phosphate transmembrane transporter activity
HRR99_01340	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HRR99_01345	COG0704	Plays a role in the regulation of phosphate uptake
HRR99_01350	COG0745	RESPONSE REGULATOR receiver
HRR99_01355	COG1278	Cold shock
HRR99_01375	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HRR99_01380	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HRR99_01395	COG2967	ApaG domain
HRR99_01405	COG0717	Belongs to the dCTP deaminase family
HRR99_01455	COG0167	dihydroorotate dehydrogenase activity
HRR99_01480	COG1201	RNA secondary structure unwinding
HRR99_01495	COG0730	response to heat
HRR99_01505	COG1960	acyl-CoA dehydrogenase activity
HRR99_01510	COG0183	Belongs to the thiolase family
HRR99_01520	COG1250	3-hydroxyacyl-CoA dehydrogenase
HRR99_01520	COG1024	Enoyl-CoA hydratase
HRR99_01550	COG1157	protein secretion by the type III secretion system
HRR99_01555	COG4786	Flagellar basal body rod
HRR99_01560	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HRR99_01565	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HRR99_01570	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HRR99_01575	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HRR99_01580	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HRR99_01590	COG0436	Aminotransferase
HRR99_01595	COG1970	mechanosensitive ion channel activity
HRR99_01600	COG2198	Histidine kinase
HRR99_01600	COG2205	protein histidine kinase activity
HRR99_01600	COG0784	Response regulator, receiver
HRR99_01605	COG2972	Histidine kinase
HRR99_01605	COG0840	transmembrane signaling receptor activity
HRR99_01610	COG1320	monovalent cation:proton antiporter activity
HRR99_01615	COG2212	antiporter activity
HRR99_01620	COG1863	multisubunit Na H antiporter MnhE subunit
HRR99_01625	COG0651	ATP synthesis coupled electron transport
HRR99_01630	COG1006	Multisubunit Na H antiporter MnhC subunit
HRR99_01635	COG2111	Na H antiporter
HRR99_01635	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HRR99_01645	COG0840	transmembrane signaling receptor activity
HRR99_01655	COG0745	RESPONSE REGULATOR receiver
HRR99_01660	COG2198	Histidine kinase
HRR99_01660	COG0643	Histidine kinase
HRR99_01665	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HRR99_01670	COG2201	protein-glutamate methylesterase activity
HRR99_01675	COG0745	RESPONSE REGULATOR receiver
HRR99_01680	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
HRR99_01705	COG1766	The M ring may be actively involved in energy transduction
HRR99_01710	COG2771	luxR family
HRR99_01730	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HRR99_01735	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HRR99_01740	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HRR99_01750	COG1360	Flagellar Motor Protein
HRR99_01775	COG1749	Flagellar hook protein flgE
HRR99_01790	COG5442	Flagellar protein FlaF
HRR99_01795	COG5443	negative regulation of bacterial-type flagellum assembly
HRR99_01800	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
HRR99_01805	COG4794	Type iii secretion
HRR99_01825	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HRR99_01835	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HRR99_01840	COG5328	Belongs to the UPF0262 family
HRR99_01850	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HRR99_01855	COG0424	maF-like protein
HRR99_01860	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
HRR99_01870	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HRR99_01900	COG1338	Plays a role in the flagellum-specific transport system
HRR99_01910	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
HRR99_01920	COG1706	bacterial-type flagellum-dependent cell motility
HRR99_01925	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
HRR99_01930	COG4786	Flagellar basal body rod
HRR99_01935	COG1677	Flagellar hook-basal body complex protein FliE
HRR99_01940	COG1558	bacterial-type flagellum-dependent cell motility
HRR99_01945	COG1815	bacterial-type flagellum-dependent cell motility
HRR99_01955	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HRR99_01960	COG1609	Transcriptional regulator
HRR99_01965	COG1653	transport
HRR99_01970	COG1175	transmembrane transport
HRR99_01975	COG0395	ABC-type sugar transport system, permease component
HRR99_01980	COG0366	Alpha amylase catalytic
HRR99_01985	COG3842	ATPase activity
HRR99_02000	COG0129	dihydroxy-acid dehydratase activity
HRR99_02005	COG0363	glucosamine-6-phosphate deaminase activity
HRR99_02010	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HRR99_02015	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HRR99_02025	COG2081	HI0933 family
HRR99_02040	COG2224	Isocitrate lyase
HRR99_02055	COG3842	ATPase activity
HRR99_02060	COG1176	ABC-type spermidine putrescine transport system, permease component I
HRR99_02065	COG1177	transmembrane transport
HRR99_02080	COG1177	transmembrane transport
HRR99_02085	COG2205	protein histidine kinase activity
HRR99_02100	COG0248	Ppx GppA phosphatase
HRR99_02105	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
HRR99_02110	COG0477	Major facilitator Superfamily
HRR99_02130	COG0412	Dienelactone hydrolase
HRR99_02135	COG0583	DNA-binding transcription factor activity
HRR99_02155	COG0306	phosphate transporter
HRR99_02165	COG0561	phosphatase activity
HRR99_02170	COG0438	transferase activity, transferring glycosyl groups
HRR99_02175	COG0277	FAD linked oxidase domain protein
HRR99_02180	COG0277	FAD linked oxidase domain protein
HRR99_02185	COG0247	lactate metabolic process
HRR99_02190	COG1376	ErfK ybiS ycfS ynhG family protein
HRR99_02195	COG2818	Glycosylase
HRR99_02225	COG0124	histidyl-tRNA synthetase
HRR99_02230	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
HRR99_02235	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HRR99_02240	COG2259	Doxx family
HRR99_02250	COG0459	protein refolding
HRR99_02255	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HRR99_02260	COG2059	Chromate
HRR99_02275	COG0196	riboflavin kinase activity
HRR99_02280	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HRR99_02290	COG0590	tRNA wobble adenosine to inosine editing
HRR99_02295	COG1187	pseudouridine synthase activity
HRR99_02300	COG0742	ribosomal rna small subunit methyltransferase
HRR99_02310	COG0312	modulator of DNA gyrase
HRR99_02315	COG0483	inositol monophosphate 1-phosphatase activity
HRR99_02325	COG1519	Transferase
HRR99_02335	COG1663	tetraacyldisaccharide 4'-kinase activity
HRR99_02350	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HRR99_02355	COG2198	Histidine kinase
HRR99_02355	COG5002	protein histidine kinase activity
HRR99_02355	COG0784	Response regulator, receiver
HRR99_02360	COG3300	MHYT domain
HRR99_02360	COG5001	Diguanylate cyclase
HRR99_02365	COG3386	PFAM SMP-30 Gluconolaconase
HRR99_02370	COG0800	Aldolase
HRR99_02375	COG3734	2-keto-3-deoxy-galactonokinase
HRR99_02380	COG1028	Short-chain dehydrogenase reductase Sdr
HRR99_02390	COG2197	response regulator
HRR99_02400	COG0489	protein tyrosine kinase activity
HRR99_02405	COG0598	Magnesium transport protein CorA
HRR99_02410	COG3158	transport of potassium into the cell
HRR99_02425	COG0356	it plays a direct role in the translocation of protons across the membrane
HRR99_02435	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HRR99_02440	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HRR99_02445	COG0840	transmembrane signaling receptor activity
HRR99_02450	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HRR99_02465	COG0521	Mo-molybdopterin cofactor biosynthetic process
HRR99_02470	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HRR99_02480	COG0142	geranyltranstransferase activity
HRR99_02515	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HRR99_02520	COG1704	LemA family
HRR99_02525	COG0752	glycyl-tRNA synthetase alpha subunit
HRR99_02530	COG0751	glycine-tRNA ligase activity
HRR99_02555	COG0840	transmembrane signaling receptor activity
HRR99_02570	COG0151	Belongs to the GarS family
HRR99_02575	COG2183	response to ionizing radiation
HRR99_02580	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HRR99_02600	COG0009	L-threonylcarbamoyladenylate synthase
HRR99_02610	COG4638	Rieske (2fe-2S)
HRR99_02635	COG1960	acyl-CoA dehydrogenase activity
HRR99_02650	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HRR99_02660	COG0840	transmembrane signaling receptor activity
HRR99_02665	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HRR99_02670	COG1741	Belongs to the pirin family
HRR99_02675	COG1722	exodeoxyribonuclease VII activity
HRR99_02680	COG0123	including yeast histone deacetylase and acetoin utilization protein
HRR99_02685	COG1268	BioY protein
HRR99_02690	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HRR99_02695	COG1122	ATPase activity
HRR99_02700	COG3214	Protein conserved in bacteria
HRR99_02710	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HRR99_02730	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HRR99_02735	COG0484	heat shock protein binding
HRR99_02745	COG0259	pyridoxamine-phosphate oxidase activity
HRR99_02750	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HRR99_02765	COG0312	modulator of DNA gyrase
HRR99_02780	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HRR99_02785	COG0109	protoheme IX farnesyltransferase activity
HRR99_02790	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
HRR99_02805	COG3346	SURF1 family
HRR99_02810	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HRR99_02815	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HRR99_02820	COG0328	RNA-DNA hybrid ribonuclease activity
HRR99_02835	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HRR99_02840	COG1121	(ABC) transporter
HRR99_02845	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HRR99_02845	COG0678	peroxiredoxin activity
HRR99_02855	COG1678	Uncharacterized ACR, COG1678
HRR99_02875	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HRR99_02880	COG0612	Peptidase, M16
HRR99_02910	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HRR99_02920	COG1268	BioY protein
HRR99_02935	COG2189	Belongs to the N(4) N(6)-methyltransferase family
HRR99_02945	COG1194	a g-specific adenine glycosylase
HRR99_02960	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HRR99_02965	COG1196	nuclear chromosome segregation
HRR99_02975	COG0574	Belongs to the PEP-utilizing enzyme family
HRR99_02975	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HRR99_03015	COG0579	oxidoreductase
HRR99_03210	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HRR99_03400	COG1609	Transcriptional regulator
HRR99_03405	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HRR99_03415	COG2895	sulfate adenylyltransferase (ATP) activity
HRR99_03420	COG0175	sulfate reduction
HRR99_03430	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
HRR99_03435	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
HRR99_03440	COG4208	sulfate ABC transporter
HRR99_03445	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HRR99_03465	COG2200	EAL domain
HRR99_03465	COG2199	diguanylate cyclase activity
HRR99_03465	COG2203	Gaf domain
HRR99_03475	COG1309	transcriptional regulator
HRR99_03480	COG1012	belongs to the aldehyde dehydrogenase family
HRR99_03485	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
HRR99_03520	COG5001	Diguanylate cyclase
HRR99_03520	COG3300	MHYT domain
HRR99_03530	COG0477	Major facilitator Superfamily
HRR99_03540	COG1793	dna ligase
HRR99_03550	COG1376	ErfK ybiS ycfS ynhG family protein
HRR99_03555	COG1376	ErfK ybiS ycfS ynhG family protein
HRR99_03565	COG1846	Transcriptional regulator
HRR99_03570	COG1764	response to oxidative stress
HRR99_03620	COG0433	COG0433 Predicted ATPase
HRR99_03630	COG1733	regulation of RNA biosynthetic process
HRR99_03635	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
HRR99_03640	COG3385	transposase activity
HRR99_03645	COG0656	L-ascorbic acid biosynthetic process
HRR99_03655	COG2378	regulation of single-species biofilm formation
HRR99_03665	COG4106	trans-aconitate 2-methyltransferase activity
HRR99_03685	COG0583	DNA-binding transcription factor activity
HRR99_03700	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HRR99_03715	COG3909	cytochrome
HRR99_03720	COG2010	Cytochrome c
HRR99_03740	COG0693	protein deglycase activity
HRR99_03745	COG0456	acetyltransferase
HRR99_03760	COG0789	Transcriptional regulator
HRR99_03780	COG0517	IMP dehydrogenase activity
HRR99_03780	COG4175	Glycine betaine
HRR99_03785	COG4176	ABC-type proline glycine betaine transport system permease component
HRR99_03795	COG3385	transposase activity
HRR99_03810	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HRR99_03825	COG2514	catechol 2,3-dioxygenase activity
HRR99_03835	COG1272	protein, Hemolysin III
HRR99_03855	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HRR99_03860	COG2111	Na H antiporter
HRR99_03860	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HRR99_03865	COG2111	Na H antiporter
HRR99_03870	COG1006	Multisubunit Na H antiporter MnhC subunit
HRR99_03875	COG0651	ATP synthesis coupled electron transport
HRR99_03880	COG1863	multisubunit Na H antiporter MnhE subunit
HRR99_03885	COG2212	antiporter activity
HRR99_03890	COG1320	monovalent cation:proton antiporter activity
HRR99_03895	COG4957	zinc ion binding
HRR99_03910	COG2166	iron-sulfur cluster assembly
HRR99_03920	COG2205	protein histidine kinase activity
HRR99_03975	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HRR99_03980	COG2983	Belongs to the UPF0260 family
HRR99_04040	COG1621	beta-fructofuranosidase activity
HRR99_04055	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
HRR99_04105	COG4695	Portal protein
HRR99_04215	COG4235	cytochrome complex assembly
HRR99_04220	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
HRR99_04225	COG1138	Cytochrome C-type biogenesis protein
HRR99_04230	COG3088	subunit of a heme lyase
HRR99_04235	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HRR99_04245	COG2205	protein histidine kinase activity
HRR99_04250	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
HRR99_04260	COG1408	metallophosphoesterase
HRR99_04265	COG2202	Pas domain
HRR99_04265	COG2205	protein histidine kinase activity
HRR99_04270	COG0308	aminopeptidase N
HRR99_04275	COG3290	protein histidine kinase activity
HRR99_04275	COG0840	transmembrane signaling receptor activity
HRR99_04300	COG0443	Heat shock 70 kDa protein
HRR99_04320	COG1028	Short-chain dehydrogenase reductase Sdr
HRR99_04340	COG1733	regulation of RNA biosynthetic process
HRR99_04345	COG1012	belongs to the aldehyde dehydrogenase family
HRR99_04350	COG1968	undecaprenyl-diphosphatase activity
HRR99_04360	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HRR99_04375	COG2040	homocysteine
HRR99_04385	COG2239	Acts as a magnesium transporter
HRR99_04390	COG2814	Major facilitator Superfamily
HRR99_04410	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HRR99_04415	COG0463	Glycosyl transferase, family 2
HRR99_04425	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HRR99_04465	COG2382	esterase
HRR99_04500	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HRR99_04550	COG0741	lytic transglycosylase activity
HRR99_04555	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HRR99_04560	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HRR99_04580	COG1758	RNA polymerase activity
HRR99_04600	COG0736	holo-[acyl-carrier-protein] synthase activity
HRR99_04605	COG0681	Belongs to the peptidase S26 family
HRR99_04610	COG0571	ribonuclease III activity
HRR99_04615	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HRR99_04620	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HRR99_04625	COG0784	Response regulator, receiver
HRR99_04630	COG1381	Involved in DNA repair and RecF pathway recombination
HRR99_04645	COG1418	mRNA catabolic process
HRR99_04655	COG0346	lactoylglutathione lyase activity
HRR99_04670	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HRR99_04680	COG0668	transmembrane transport
HRR99_04690	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
HRR99_04695	COG0354	folic acid binding
HRR99_04715	COG1051	belongs to the nudix hydrolase family
HRR99_04730	COG1742	UPF0060 membrane protein
HRR99_04740	COG3706	GGDEF domain
HRR99_04745	COG1183	phosphatidylcholine synthase activity
HRR99_04750	COG0688	phosphatidylethanolamine metabolic process
HRR99_04755	COG5265	(ABC) transporter
HRR99_04795	COG2852	Protein conserved in bacteria
HRR99_04800	COG0215	cysteine-tRNA ligase activity
HRR99_04805	COG4221	oxidoreductase activity
HRR99_04810	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HRR99_04815	COG1286	toxin biosynthetic process
HRR99_04835	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HRR99_04870	COG0359	binds to the 23S rRNA
HRR99_04880	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HRR99_04885	COG0360	Binds together with S18 to 16S ribosomal RNA
HRR99_04890	COG0667	Aldo Keto reductase
HRR99_04905	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HRR99_04910	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HRR99_04915	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HRR99_04920	COG1561	YicC-like family, N-terminal region
HRR99_04925	COG0194	GDP metabolic process
HRR99_04940	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HRR99_04945	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HRR99_04955	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
HRR99_04975	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HRR99_04995	COG0726	polysaccharide deacetylase
HRR99_05000	COG0488	(ABC) transporter
HRR99_05005	COG3706	GGDEF domain
HRR99_05015	COG0105	UTP biosynthetic process
HRR99_05035	COG0314	molybdopterin synthase activity
HRR99_05045	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HRR99_05050	COG0322	excinuclease ABC activity
HRR99_05055	COG1028	Short-chain dehydrogenase reductase Sdr
HRR99_05065	COG0625	glutathione transferase activity
HRR99_05080	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
HRR99_05085	COG0243	molybdopterin cofactor binding
HRR99_05090	COG0494	nUDIX hydrolase
HRR99_05100	COG3668	Plasmid stabilization system
HRR99_05105	COG3609	addiction module antidote protein, CC2985 family
HRR99_05110	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HRR99_05115	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HRR99_05120	COG0628	permease
HRR99_05130	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HRR99_05135	COG0248	Ppx GppA phosphatase
HRR99_05145	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
HRR99_05150	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
HRR99_05155	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HRR99_05165	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HRR99_05190	COG2382	esterase
HRR99_05195	COG0556	nucleotide-excision repair
HRR99_05245	COG1607	acyl-coa hydrolase
HRR99_05250	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HRR99_05270	COG0861	Integral membrane protein TerC family
HRR99_05275	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HRR99_05280	COG1086	Polysaccharide biosynthesis protein
HRR99_05290	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HRR99_05300	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HRR99_05305	COG0081	regulation of translation
HRR99_05310	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HRR99_05315	COG0222	ribosome binding
HRR99_05320	COG0085	RNA polymerase activity
HRR99_05325	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HRR99_05350	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HRR99_05355	COG0049	tRNA binding
HRR99_05360	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HRR99_05365	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HRR99_05370	COG0051	transcription antitermination factor activity, RNA binding
HRR99_05375	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HRR99_05380	COG0088	Forms part of the polypeptide exit tunnel
HRR99_05385	COG0089	rRNA binding
HRR99_05390	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HRR99_05395	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HRR99_05400	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HRR99_05405	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HRR99_05410	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HRR99_05415	COG0255	Belongs to the universal ribosomal protein uL29 family
HRR99_05420	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HRR99_05425	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HRR99_05430	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HRR99_05435	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HRR99_05440	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HRR99_05445	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HRR99_05450	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HRR99_05455	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HRR99_05460	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HRR99_05465	COG1841	ribosomal large subunit assembly
HRR99_05470	COG0200	Binds to the 23S rRNA
HRR99_05475	COG0201	protein transport
HRR99_05480	COG0563	adenylate kinase activity
HRR99_05485	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HRR99_05490	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HRR99_05495	COG0202	RNA polymerase activity
HRR99_05500	COG0203	ribosomal protein L17
HRR99_05515	COG3739	integral membrane protein
HRR99_05525	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
HRR99_05530	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HRR99_05535	COG0737	Belongs to the 5'-nucleotidase family
HRR99_05555	COG2897	thiosulfate sulfurtransferase activity
HRR99_05570	COG0415	Belongs to the DNA photolyase family
HRR99_05610	COG3932	Exopolysaccharide synthesis, ExoD
HRR99_05615	COG1238	metal cluster binding
HRR99_05705	COG4695	Portal protein
HRR99_05710	COG0616	signal peptide processing
HRR99_05850	COG4974	Belongs to the 'phage' integrase family
HRR99_05915	COG1612	heme a metabolic process
HRR99_05925	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HRR99_05930	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HRR99_05935	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HRR99_05945	COG1832	CoA-binding protein
HRR99_05970	COG0405	Gamma-glutamyltransferase
HRR99_05975	COG2199	diguanylate cyclase activity
HRR99_05980	COG0740	serine-type endopeptidase activity
HRR99_05985	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HRR99_05990	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HRR99_06015	COG4948	Mandelate Racemase Muconate Lactonizing
HRR99_06020	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HRR99_06025	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HRR99_06050	COG1404	Belongs to the peptidase S8 family
HRR99_06075	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HRR99_06080	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HRR99_06085	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HRR99_06095	COG0649	NAD binding
HRR99_06105	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
HRR99_06110	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
HRR99_06120	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HRR99_06125	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HRR99_06150	COG1007	ATP synthesis coupled electron transport
HRR99_06165	COG0346	lactoylglutathione lyase activity
HRR99_06175	COG0442	prolyl-tRNA aminoacylation
HRR99_06185	COG1136	(ABC) transporter
HRR99_06205	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HRR99_06215	COG0784	Response regulator, receiver
HRR99_06230	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HRR99_06250	COG0557	exoribonuclease II activity
HRR99_06255	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HRR99_06255	COG1754	DNA topoisomerase type I activity
HRR99_06265	COG0758	DNA mediated transformation
HRR99_06270	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HRR99_06275	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HRR99_06280	COG0540	Belongs to the ATCase OTCase family
HRR99_06285	COG1960	acyl-CoA dehydrogenase activity
HRR99_06315	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HRR99_06320	COG2824	Alkylphosphonate utilization operon protein PhnA
HRR99_06325	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HRR99_06330	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HRR99_06335	COG0154	amidase activity
HRR99_06350	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HRR99_06360	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HRR99_06365	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
HRR99_06370	COG2199	diguanylate cyclase activity
HRR99_06390	COG0626	cystathionine gamma-synthase activity
HRR99_06395	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HRR99_06400	COG4597	amino acid ABC transporter
HRR99_06405	COG0765	amino acid transport
HRR99_06410	COG1126	abc transporter atp-binding protein
HRR99_06420	COG0316	Belongs to the HesB IscA family
HRR99_06425	COG0232	Belongs to the dGTPase family. Type 2 subfamily
HRR99_06430	COG0018	arginyl-trna synthetase
HRR99_06440	COG1472	Belongs to the glycosyl hydrolase 3 family
HRR99_06445	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
HRR99_06450	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HRR99_06455	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HRR99_06460	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HRR99_06465	COG0805	protein transport
HRR99_06470	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HRR99_06475	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
HRR99_06480	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HRR99_06485	COG0739	heme binding
HRR99_06490	COG1763	Mo-molybdopterin cofactor biosynthetic process
HRR99_06495	COG0746	molybdenum cofactor guanylyltransferase activity
HRR99_06500	COG2814	Major facilitator Superfamily
HRR99_06505	COG0697	spore germination
HRR99_06510	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HRR99_06520	COG0475	glutathione-regulated potassium exporter activity
HRR99_06520	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HRR99_06530	COG3706	GGDEF domain
HRR99_06535	COG0114	fumarate hydratase activity
HRR99_06540	COG2989	Protein conserved in bacteria
HRR99_06545	COG2066	Belongs to the glutaminase family
HRR99_06550	COG0037	tRNA processing
HRR99_06555	COG0483	inositol monophosphate 1-phosphatase activity
HRR99_06560	COG0483	inositol monophosphate 1-phosphatase activity
HRR99_06565	COG2814	Major facilitator Superfamily
HRR99_06570	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HRR99_06580	COG0187	DNA topoisomerase II activity
HRR99_06590	COG0149	triose-phosphate isomerase activity
HRR99_06600	COG0504	CTP synthase activity
HRR99_06610	COG0303	'Molybdopterin
HRR99_06615	COG0315	cyclic pyranopterin monophosphate synthase activity
HRR99_06620	COG0134	indole-3-glycerol-phosphate synthase activity
HRR99_06625	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HRR99_06640	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HRR99_06655	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HRR99_06660	COG0343	queuine tRNA-ribosyltransferase activity
HRR99_06665	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HRR99_06675	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HRR99_06680	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HRR99_06685	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HRR99_06690	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HRR99_06695	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HRR99_06730	COG0436	Aminotransferase
HRR99_06790	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HRR99_06795	COG1609	Transcriptional regulator
HRR99_06805	COG0667	Aldo Keto reductase
HRR99_06815	COG0523	cobalamin synthesis protein
HRR99_06825	COG1121	(ABC) transporter
HRR99_06830	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HRR99_06850	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HRR99_06860	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HRR99_06865	COG0629	single-stranded DNA binding
HRR99_06880	COG2095	MarC family integral membrane protein
HRR99_06895	COG1686	Belongs to the peptidase S11 family
HRR99_06945	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HRR99_06955	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HRR99_06960	COG0084	hydrolase, TatD family'
HRR99_06965	COG0321	lipoyl(octanoyl) transferase activity
HRR99_06965	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HRR99_06970	COG0038	chloride channel
HRR99_07020	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
HRR99_07020	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
HRR99_07045	COG1028	Short-chain dehydrogenase reductase Sdr
HRR99_07090	COG0596	Alpha beta hydrolase
HRR99_07200	COG2378	regulation of single-species biofilm formation
HRR99_07205	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HRR99_07210	COG0587	DNA-directed DNA polymerase activity
HRR99_07225	COG0784	Response regulator, receiver
HRR99_07265	COG2226	methyltransferase
HRR99_07335	COG2801	Transposase and inactivated derivatives
HRR99_07350	COG0464	growth
HRR99_07360	COG2801	Transposase and inactivated derivatives
HRR99_07365	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HRR99_07375	COG1671	Belongs to the UPF0178 family
HRR99_07385	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
HRR99_07400	COG0546	phosphoglycolate phosphatase activity
HRR99_07405	COG0564	pseudouridine synthase activity
HRR99_07410	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HRR99_07435	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HRR99_07440	COG0509	glycine decarboxylation via glycine cleavage system
HRR99_07445	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HRR99_07445	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HRR99_07480	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HRR99_07480	COG1648	precorrin-2 dehydrogenase activity
HRR99_07490	COG3956	TIGRFAM MazG family protein
HRR99_07500	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HRR99_07505	COG1923	regulation of RNA biosynthetic process
HRR99_07510	COG0569	domain protein
HRR99_07515	COG2204	response regulator
HRR99_07520	COG5000	phosphorelay sensor kinase activity
HRR99_07525	COG2204	response regulator
HRR99_07530	COG3852	Histidine kinase
HRR99_07540	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HRR99_07540	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HRR99_07545	COG1058	Belongs to the CinA family
HRR99_07545	COG1546	Belongs to the CinA family
HRR99_07550	COG2867	negative regulation of translational initiation
HRR99_07570	COG0697	spore germination
HRR99_07575	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HRR99_07590	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HRR99_07600	COG0508	dehydrogenase complex catalyzes the overall conversion of
HRR99_07610	COG0508	dehydrogenase complex catalyzes the overall conversion of
HRR99_07610	COG0022	dehydrogenase e1 component
HRR99_07615	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HRR99_07625	COG0148	phosphopyruvate hydratase activity
HRR99_07630	COG2877	3-deoxy-8-phosphooctulonate synthase activity
HRR99_07635	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HRR99_07665	COG0765	amino acid transport
HRR99_07670	COG0765	amino acid transport
HRR99_07680	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HRR99_07685	COG3494	Protein of unknown function (DUF1009)
HRR99_07690	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HRR99_07695	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HRR99_07700	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HRR99_07705	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HRR99_07710	COG0750	zinc metalloprotease
HRR99_07720	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HRR99_07725	COG0233	cytoplasmic translational termination
HRR99_07730	COG0528	UMP kinase activity
HRR99_07735	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HRR99_07740	COG0052	Belongs to the universal ribosomal protein uS2 family
HRR99_07790	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HRR99_07815	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
HRR99_07820	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HRR99_07825	COG0511	ligase activity, forming carbon-carbon bonds
HRR99_07830	COG0439	Biotin carboxylase
HRR99_07835	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
HRR99_07860	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HRR99_07895	COG2239	Acts as a magnesium transporter
HRR99_07900	COG0243	molybdopterin cofactor binding
HRR99_07910	COG0242	peptide deformylase activity
HRR99_07925	COG0823	Involved in the tonB-independent uptake of proteins
HRR99_07940	COG1368	sulfuric ester hydrolase activity
HRR99_07960	COG0544	peptidyl-prolyl cis-trans isomerase activity
HRR99_07995	COG0384	phenazine biosynthesis protein PhzF
HRR99_08000	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HRR99_08020	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HRR99_08025	COG0860	N-Acetylmuramoyl-L-alanine amidase
HRR99_08030	COG1530	ribonuclease E activity
HRR99_08035	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
HRR99_08050	COG3106	COG3106 Predicted ATPase
HRR99_08055	COG3768	UPF0283 membrane protein
HRR99_08065	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HRR99_08070	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HRR99_08075	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HRR99_08085	COG0633	Ferredoxin
HRR99_08105	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HRR99_08105	COG3218	ABC-type transport auxiliary lipoprotein component
HRR99_08115	COG1127	ABC transporter
HRR99_08120	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HRR99_08125	COG4948	Mandelate Racemase Muconate Lactonizing
HRR99_08135	COG0280	phosphate acetyltransferase
HRR99_08135	COG0281	malic enzyme
HRR99_08145	COG0778	Nitroreductase
HRR99_08155	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HRR99_08165	COG0745	RESPONSE REGULATOR receiver
HRR99_08170	COG0784	Response regulator, receiver
HRR99_08170	COG4191	Histidine kinase
HRR99_08175	COG1028	Short-chain dehydrogenase reductase Sdr
HRR99_08180	COG0436	Aminotransferase
HRR99_08200	COG3243	poly(R)-hydroxyalkanoic acid synthase
HRR99_08205	COG1489	DNA binding
HRR99_08210	COG0024	Methionine aminopeptidase
HRR99_08215	COG2003	Belongs to the UPF0758 family
HRR99_08230	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
HRR99_08245	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
HRR99_08250	COG0546	phosphoglycolate phosphatase activity
HRR99_08255	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HRR99_08260	COG0861	Integral membrane protein TerC family
HRR99_08280	COG1280	lysine exporter protein (LysE YggA)
HRR99_08295	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HRR99_08300	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
HRR99_08310	COG0538	isocitrate dehydrogenase activity
HRR99_08320	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HRR99_08325	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HRR99_08330	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HRR99_08335	COG2313	pseudouridylate synthase activity
HRR99_08345	COG5425	PFAM Usg family protein
HRR99_08370	COG1522	sequence-specific DNA binding
HRR99_08375	COG1573	uracil-dna glycosylase
HRR99_08385	COG2202	Pas domain
HRR99_08385	COG2205	protein histidine kinase activity
HRR99_08395	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
HRR99_08400	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
HRR99_08425	COG0525	valine-tRNA ligase activity
HRR99_08455	COG3264	Mechanosensitive ion channel
HRR99_08455	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
HRR99_08470	COG2067	long-chain fatty acid transport protein
HRR99_08475	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
HRR99_08490	COG3737	Protein of unknown function (DUF498/DUF598)
HRR99_08500	COG1862	Preprotein translocase
HRR99_08520	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HRR99_08525	COG0739	heme binding
HRR99_08530	COG0513	Belongs to the DEAD box helicase family
HRR99_08550	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HRR99_08570	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HRR99_08575	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HRR99_08580	COG0047	phosphoribosylformylglycinamidine synthase activity
HRR99_08595	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HRR99_08600	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HRR99_08625	COG0321	lipoyl(octanoyl) transferase activity
HRR99_08630	COG1064	alcohol dehydrogenase
HRR99_08640	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HRR99_08670	COG1546	Belongs to the CinA family
HRR99_08670	COG1058	Belongs to the CinA family
HRR99_08675	COG0589	response to stress
HRR99_08680	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
HRR99_08685	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HRR99_08690	COG3385	transposase activity
HRR99_08695	COG0842	Transport permease protein
HRR99_08700	COG1131	(ABC) transporter
HRR99_08720	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HRR99_08750	COG0129	dihydroxy-acid dehydratase activity
HRR99_08755	COG0583	DNA-binding transcription factor activity
HRR99_08760	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HRR99_08770	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HRR99_08775	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HRR99_08780	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HRR99_08780	COG2755	lipolytic protein G-D-S-L family
HRR99_08800	COG0776	regulation of translation
HRR99_08805	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HRR99_08810	COG0416	fatty acid biosynthetic process
HRR99_08830	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
HRR99_08835	COG2814	Major facilitator Superfamily
HRR99_08840	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HRR99_08845	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HRR99_08855	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HRR99_08855	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HRR99_08860	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HRR99_08865	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HRR99_08885	COG0113	porphobilinogen synthase activity
HRR99_08895	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
HRR99_08905	COG0484	heat shock protein binding
HRR99_08935	COG4149	molybdate abc transporter
HRR99_08945	COG0384	phenazine biosynthesis protein PhzF
HRR99_08950	COG3385	transposase activity
HRR99_08955	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HRR99_08970	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HRR99_08980	COG1733	regulation of RNA biosynthetic process
HRR99_08985	COG0702	epimerase
HRR99_09005	COG2267	carboxylic ester hydrolase activity
HRR99_09010	COG1045	serine acetyltransferase
HRR99_09030	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HRR99_09050	COG1132	(ABC) transporter
HRR99_09055	COG0628	permease
HRR99_09095	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HRR99_09105	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HRR99_09115	COG0302	gtp cyclohydrolase
HRR99_09120	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HRR99_09125	COG1752	Esterase of the alpha-beta hydrolase superfamily
HRR99_09130	COG3385	transposase activity
HRR99_09135	COG0517	IMP dehydrogenase activity
HRR99_09135	COG0516	GMP reductase activity
HRR99_09165	COG1760	l-serine dehydratase
HRR99_09185	COG0583	DNA-binding transcription factor activity
HRR99_09200	COG0745	RESPONSE REGULATOR receiver
HRR99_09210	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HRR99_09210	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HRR99_09215	COG0347	Belongs to the P(II) protein family
HRR99_09220	COG0174	glutamine synthetase
HRR99_09250	COG0697	spore germination
HRR99_09260	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HRR99_09270	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HRR99_09290	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HRR99_09295	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HRR99_09310	COG1079	Belongs to the binding-protein-dependent transport system permease family
HRR99_09315	COG1172	Belongs to the binding-protein-dependent transport system permease family
HRR99_09320	COG3845	ABC transporter
HRR99_09325	COG1183	phosphatidylcholine synthase activity
HRR99_09330	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HRR99_09335	COG0679	Auxin Efflux Carrier
HRR99_09340	COG0785	Cytochrome C biogenesis protein
HRR99_09360	COG0346	lactoylglutathione lyase activity
HRR99_09365	COG1278	Cold shock
HRR99_09410	COG0443	Heat shock 70 kDa protein
HRR99_09435	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HRR99_09550	COG0840	transmembrane signaling receptor activity
HRR99_09560	COG1136	(ABC) transporter
HRR99_09560	COG0577	efflux transmembrane transporter activity
HRR99_09565	COG1136	(ABC) transporter
HRR99_09565	COG0577	efflux transmembrane transporter activity
HRR99_09570	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HRR99_09580	COG3385	transposase activity
HRR99_09585	COG0316	Belongs to the HesB IscA family
HRR99_09590	COG2151	metal-sulfur cluster biosynthetic enzyme
HRR99_09595	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HRR99_09600	COG0719	Fe-S assembly protein
HRR99_09605	COG0396	ATPase activity
HRR99_09615	COG0719	Fe-S assembly protein
HRR99_09620	COG1104	cysteine desulfurase activity
HRR99_09625	COG2945	thiolester hydrolase activity
HRR99_09630	COG1252	NADH dehydrogenase
HRR99_09635	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HRR99_09645	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HRR99_09650	COG2972	Histidine kinase
HRR99_09650	COG0840	transmembrane signaling receptor activity
HRR99_09655	COG1280	lysine exporter protein (LysE YggA)
HRR99_09660	COG0656	L-ascorbic acid biosynthetic process
HRR99_09665	COG0840	transmembrane signaling receptor activity
HRR99_09680	COG0440	acetolactate synthase activity
HRR99_09685	COG0028	Belongs to the TPP enzyme family
HRR99_09695	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HRR99_09700	COG0560	Phosphoserine phosphatase
HRR99_09700	COG3830	Belongs to the UPF0237 family
HRR99_09710	COG1116	anion transmembrane transporter activity
HRR99_09725	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HRR99_09750	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
HRR99_09760	COG0330	HflC and HflK could
HRR99_09765	COG0330	HflC and HflK could
HRR99_09790	COG0277	FAD linked oxidase domain protein
HRR99_09795	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HRR99_09800	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HRR99_09830	COG1335	isochorismatase
HRR99_09860	COG2264	protein methyltransferase activity
HRR99_09870	COG0835	chemotaxis
HRR99_09880	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HRR99_09885	COG0697	spore germination
HRR99_09890	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HRR99_09895	COG1280	lysine exporter protein (LysE YggA)
HRR99_09900	COG0497	DNA recombination
HRR99_09905	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HRR99_09915	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HRR99_09920	COG0849	cell division
HRR99_09925	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HRR99_09930	COG1181	Belongs to the D-alanine--D-alanine ligase family
HRR99_09940	COG0477	Major facilitator Superfamily
HRR99_09950	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HRR99_09955	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HRR99_09960	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HRR99_09970	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HRR99_09975	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HRR99_09985	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HRR99_10000	COG0275	rRNA processing
HRR99_10005	COG2001	Belongs to the MraZ family
HRR99_10015	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HRR99_10030	COG3023	N-Acetylmuramoyl-L-alanine amidase
HRR99_10085	COG2226	methyltransferase
HRR99_10100	COG0840	transmembrane signaling receptor activity
HRR99_10130	COG2267	carboxylic ester hydrolase activity
HRR99_10135	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HRR99_10150	COG0251	oxidation-reduction process
HRR99_10165	COG1376	ErfK ybiS ycfS ynhG family protein
HRR99_10170	COG2814	Major facilitator Superfamily
HRR99_10175	COG1309	transcriptional regulator
HRR99_10190	COG1012	belongs to the aldehyde dehydrogenase family
HRR99_10200	COG0531	amino acid
HRR99_10210	COG1737	Transcriptional regulator
HRR99_10220	COG1178	ABC-type Fe3 transport system permease component
HRR99_10230	COG3842	ATPase activity
HRR99_10285	COG2968	Membrane
HRR99_10295	COG0432	Pfam Uncharacterised protein family UPF0047
HRR99_10300	COG4251	negative regulation of phosphorylation
HRR99_10310	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HRR99_10315	COG0358	DNA primase activity
HRR99_10335	COG0505	Belongs to the CarA family
HRR99_10340	COG0534	Mate efflux family protein
HRR99_10355	COG2321	neutral zinc metallopeptidase
HRR99_10365	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HRR99_10375	COG1573	uracil-dna glycosylase
HRR99_10385	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HRR99_10390	COG0438	transferase activity, transferring glycosyl groups
HRR99_10395	COG0438	transferase activity, transferring glycosyl groups
HRR99_10400	COG0463	Glycosyl transferase, family 2
HRR99_10410	COG1522	sequence-specific DNA binding
HRR99_10415	COG0492	ferredoxin-NADP+ reductase activity
HRR99_10420	COG0583	DNA-binding transcription factor activity
HRR99_10435	COG1902	pentaerythritol trinitrate reductase activity
HRR99_10455	COG0387	Pfam Sodium calcium exchanger
HRR99_10475	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HRR99_10485	COG1278	Cold shock
HRR99_10490	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HRR99_10500	COG1846	Transcriptional regulator
HRR99_10505	COG0745	RESPONSE REGULATOR receiver
HRR99_10510	COG2205	protein histidine kinase activity
HRR99_10515	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HRR99_10540	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HRR99_10550	COG1496	oxidoreductase activity
HRR99_10565	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HRR99_10575	COG1012	belongs to the aldehyde dehydrogenase family
HRR99_10585	COG3300	MHYT domain
HRR99_10585	COG5001	Diguanylate cyclase
HRR99_10590	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HRR99_10595	COG3300	MHYT domain
HRR99_10595	COG5001	Diguanylate cyclase
HRR99_10605	COG0193	aminoacyl-tRNA hydrolase activity
HRR99_10635	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HRR99_10640	COG2857	Cytochrome c1
HRR99_10640	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HRR99_10660	COG1132	(ABC) transporter
HRR99_10665	COG1132	(ABC) transporter
HRR99_10670	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HRR99_10685	COG0408	coproporphyrinogen oxidase activity
HRR99_10700	COG0617	tRNA 3'-terminal CCA addition
HRR99_10715	COG0714	Associated with various cellular activities
HRR99_10735	COG0454	-acetyltransferase
HRR99_10750	COG0435	Glutathione S-transferase
HRR99_10770	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HRR99_10775	COG3135	benzoate transporter
HRR99_10785	COG1733	regulation of RNA biosynthetic process
HRR99_10795	COG0740	serine-type endopeptidase activity
HRR99_10810	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HRR99_10815	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HRR99_10830	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HRR99_10830	COG0512	Glutamine amidotransferase of anthranilate synthase
HRR99_10850	COG2197	response regulator
HRR99_10870	COG1435	thymidine kinase activity
HRR99_10885	COG4175	Glycine betaine
HRR99_10905	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
HRR99_10915	COG0366	Alpha amylase catalytic
HRR99_10920	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HRR99_10935	COG0494	nUDIX hydrolase
HRR99_10940	COG1160	GTP binding
HRR99_10960	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
HRR99_10965	COG0024	Methionine aminopeptidase
HRR99_10980	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HRR99_10985	COG1028	Short-chain dehydrogenase reductase Sdr
HRR99_11005	COG0583	DNA-binding transcription factor activity
HRR99_11015	COG0402	S-adenosylhomocysteine deaminase activity
HRR99_11020	COG0840	transmembrane signaling receptor activity
HRR99_11030	COG1304	FMN binding
HRR99_11035	COG1686	Belongs to the peptidase S11 family
HRR99_11045	COG2351	hydroxyisourate hydrolase activity
HRR99_11050	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
HRR99_11080	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HRR99_11085	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HRR99_11085	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
HRR99_11090	COG0513	Belongs to the DEAD box helicase family
HRR99_11095	COG2205	protein histidine kinase activity
HRR99_11095	COG0784	Response regulator, receiver
HRR99_11095	COG5002	protein histidine kinase activity
HRR99_11100	COG2259	Doxx family
HRR99_11115	COG1376	ErfK ybiS ycfS ynhG family protein
HRR99_11120	COG2308	Evidence 4 Homologs of previously reported genes of
HRR99_11130	COG1305	Transglutaminase-like
HRR99_11145	COG4214	carbohydrate transport
HRR99_11155	COG4213	ABC transporter substrate-binding protein
HRR99_11180	COG4213	ABC transporter substrate-binding protein
HRR99_11185	COG4214	carbohydrate transport
HRR99_11190	COG1129	ABC transporter
HRR99_11210	COG1595	DNA-templated transcription, initiation
HRR99_11255	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HRR99_11260	COG2346	COG2346, Truncated hemoglobins
HRR99_11275	COG1309	transcriptional regulator
HRR99_11295	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HRR99_11300	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HRR99_11325	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HRR99_11330	COG0830	nickel cation binding
HRR99_11335	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
HRR99_11350	COG0804	urea catabolic process
HRR99_11355	COG3755	Protein conserved in bacteria
HRR99_11360	COG0832	Belongs to the urease beta subunit family
HRR99_11365	COG3813	Protein conserved in bacteria
HRR99_11370	COG0831	urea catabolic process
HRR99_11375	COG0829	nickel cation binding
HRR99_11395	COG0411	ABC transporter
HRR99_11405	COG0559	Belongs to the binding-protein-dependent transport system permease family
HRR99_11420	COG0174	glutamine synthetase
HRR99_11425	COG2205	protein histidine kinase activity
HRR99_11425	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HRR99_11430	COG0745	RESPONSE REGULATOR receiver
HRR99_11445	COG0726	polysaccharide deacetylase
HRR99_11480	COG1218	3'(2'),5'-bisphosphate nucleotidase
HRR99_11505	COG0519	Catalyzes the synthesis of GMP from XMP
HRR99_11535	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HRR99_11545	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HRR99_11555	COG0564	pseudouridine synthase activity
HRR99_11565	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HRR99_11580	COG0346	lactoylglutathione lyase activity
HRR99_11595	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HRR99_11600	COG0346	lactoylglutathione lyase activity
HRR99_11605	COG2832	Protein of unknown function (DUF454)
HRR99_11610	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
HRR99_11615	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HRR99_11620	COG4558	Periplasmic binding protein
HRR99_11630	COG3721	Heme iron utilization protein
HRR99_11680	COG0783	Belongs to the Dps family
HRR99_11700	COG3920	Histidine kinase
HRR99_11700	COG2202	Pas domain
HRR99_11715	COG0753	catalase activity
HRR99_11730	COG0438	transferase activity, transferring glycosyl groups
HRR99_11735	COG0438	transferase activity, transferring glycosyl groups
HRR99_11745	COG0482	sulfurtransferase activity
HRR99_11760	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HRR99_11775	COG3300	MHYT domain
HRR99_11775	COG5001	Diguanylate cyclase
HRR99_11780	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HRR99_11785	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HRR99_11790	COG0037	tRNA processing
HRR99_11800	COG2885	chlorophyll binding
HRR99_11805	COG0823	Involved in the tonB-independent uptake of proteins
HRR99_11825	COG0824	Thioesterase
HRR99_11850	COG1408	metallophosphoesterase
HRR99_11855	COG2255	four-way junction helicase activity
HRR99_11870	COG0632	four-way junction helicase activity
HRR99_11875	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
HRR99_11880	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HRR99_11885	COG0563	adenylate kinase activity
HRR99_11890	COG0217	transcriptional regulatory protein
HRR99_11905	COG1692	metallophosphoesterase
HRR99_11915	COG1253	flavin adenine dinucleotide binding
HRR99_11960	COG0126	phosphoglycerate kinase activity
HRR99_11970	COG3657	addiction module killer protein
HRR99_11975	COG3588	fructose-bisphosphate aldolase
HRR99_11985	COG1132	(ABC) transporter
HRR99_11990	COG0254	rRNA binding
HRR99_12025	COG0483	inositol monophosphate 1-phosphatase activity
HRR99_12055	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HRR99_12060	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HRR99_12065	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HRR99_12085	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HRR99_12090	COG2951	lytic endotransglycosylase activity
HRR99_12115	COG1487	ribonuclease activity
HRR99_12125	COG0067	glutamate synthase
HRR99_12125	COG0069	glutamate synthase activity
HRR99_12125	COG0070	glutamate synthase
HRR99_12145	COG0071	Belongs to the small heat shock protein (HSP20) family
HRR99_12155	COG3750	Belongs to the UPF0335 family
HRR99_12175	COG0469	pyruvate kinase activity
HRR99_12185	COG3108	Peptidase M15
HRR99_12200	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HRR99_12215	COG5310	Homospermidine synthase
HRR99_12225	COG0737	Belongs to the 5'-nucleotidase family
HRR99_12230	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HRR99_12235	COG0330	HflC and HflK could
HRR99_12290	COG2307	Protein conserved in bacteria
HRR99_12290	COG2308	Evidence 4 Homologs of previously reported genes of
HRR99_12305	COG0058	SHG alpha-glucan phosphorylase activity
HRR99_12310	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HRR99_12315	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HRR99_12320	COG0297	glycogen (starch) synthase activity
HRR99_12325	COG0033	Phosphoglucomutase
HRR99_12330	COG1523	belongs to the glycosyl hydrolase 13 family
HRR99_12340	COG0531	amino acid
HRR99_12365	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HRR99_12365	COG0446	pyridine nucleotide-disulphide oxidoreductase
HRR99_12380	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HRR99_12385	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HRR99_12400	COG1132	(ABC) transporter
HRR99_12410	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HRR99_12420	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
HRR99_12425	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HRR99_12430	COG0840	transmembrane signaling receptor activity
HRR99_12430	COG2972	Histidine kinase
HRR99_12435	COG3047	cAMP biosynthetic process
HRR99_12455	COG0523	cobalamin synthesis protein
HRR99_12465	COG1846	Transcriptional regulator
HRR99_12470	COG1609	Transcriptional regulator
HRR99_12475	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HRR99_12490	COG0583	DNA-binding transcription factor activity
HRR99_12500	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
HRR99_12530	COG1566	PFAM secretion protein HlyD family protein
HRR99_12540	COG1253	flavin adenine dinucleotide binding
HRR99_12550	COG0471	metal ion transport
HRR99_12550	COG3273	potassium ion transport
HRR99_12555	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HRR99_12560	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HRR99_12565	COG3415	Transposase
HRR99_12565	COG2801	Transposase and inactivated derivatives
HRR99_12570	COG1054	Belongs to the UPF0176 family
HRR99_12585	COG0800	Aldolase
HRR99_12595	COG1609	Transcriptional regulator
HRR99_12600	COG1070	Carbohydrate kinase
HRR99_12605	COG2115	Belongs to the xylose isomerase family
HRR99_12610	COG0778	Nitroreductase
HRR99_12615	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HRR99_12620	COG2011	ABC-type metal ion transport system permease component
HRR99_12630	COG5001	Diguanylate cyclase
HRR99_12640	COG0803	Belongs to the bacterial solute-binding protein 9 family
HRR99_12645	COG1121	(ABC) transporter
HRR99_12650	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HRR99_12655	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HRR99_12665	COG3385	transposase activity
HRR99_12670	COG1028	Short-chain dehydrogenase reductase Sdr
HRR99_12675	COG1414	Transcriptional regulator
HRR99_12680	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HRR99_12700	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HRR99_12725	COG1069	ribulokinase activity
HRR99_12745	COG0395	ABC-type sugar transport system, permease component
HRR99_12750	COG1175	transmembrane transport
HRR99_12760	COG2390	Transcriptional regulator
HRR99_12770	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HRR99_12780	COG0747	negative chemotaxis
HRR99_12790	COG4608	Belongs to the ABC transporter superfamily
HRR99_12795	COG0444	Belongs to the ABC transporter superfamily
HRR99_12800	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HRR99_12805	COG0601	transmembrane transport
HRR99_12810	COG0747	negative chemotaxis
HRR99_12825	COG1473	amidohydrolase
HRR99_12830	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
HRR99_12850	COG1176	ABC-type spermidine putrescine transport system, permease component I
HRR99_12860	COG1609	Transcriptional regulator
HRR99_12865	COG0583	DNA-binding transcription factor activity
HRR99_12870	COG1960	acyl-CoA dehydrogenase activity
HRR99_12885	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HRR99_12890	COG4208	sulfate ABC transporter
HRR99_12895	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
HRR99_12900	COG4150	thiosulfate binding
HRR99_12920	COG0019	diaminopimelate decarboxylase activity
HRR99_12935	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HRR99_12940	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
HRR99_12955	COG3842	ATPase activity
HRR99_12960	COG0395	ABC-type sugar transport system, permease component
HRR99_12965	COG1175	transmembrane transport
HRR99_12990	COG0784	Response regulator, receiver
HRR99_13005	COG1522	sequence-specific DNA binding
HRR99_13015	COG1012	belongs to the aldehyde dehydrogenase family
HRR99_13020	COG0583	DNA-binding transcription factor activity
HRR99_13030	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HRR99_13035	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HRR99_13055	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HRR99_13070	COG4993	Dehydrogenase
HRR99_13075	COG0252	asparaginase activity
HRR99_13090	COG2186	Transcriptional regulator
HRR99_13095	COG3707	response regulator
HRR99_13100	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HRR99_13105	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HRR99_13115	COG1116	anion transmembrane transporter activity
HRR99_13120	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HRR99_13130	COG0243	molybdopterin cofactor binding
HRR99_13135	COG0514	ATP-dependent DNA helicase (RecQ)
HRR99_13180	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HRR99_13195	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HRR99_13205	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HRR99_13210	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
HRR99_13215	COG1509	lysine 2,3-aminomutase activity
HRR99_13230	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HRR99_13240	COG0725	ABC transporter, periplasmic molybdate-binding protein
HRR99_13245	COG4149	molybdate abc transporter
HRR99_13250	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
HRR99_13265	COG2022	thiamine diphosphate biosynthetic process
HRR99_13280	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
HRR99_13285	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HRR99_13295	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HRR99_13310	COG1132	(ABC) transporter
HRR99_13315	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HRR99_13320	COG1234	tRNA 3'-trailer cleavage
HRR99_13360	COG0747	negative chemotaxis
HRR99_13370	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HRR99_13380	COG0438	transferase activity, transferring glycosyl groups
HRR99_13385	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HRR99_13390	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HRR99_13395	COG0671	phosphoesterase, PA-phosphatase related
HRR99_13400	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HRR99_13405	COG3443	Belongs to the bacterial solute-binding protein 9 family
HRR99_13410	COG0156	8-amino-7-oxononanoate synthase activity
HRR99_13435	COG0835	chemotaxis
HRR99_13445	COG2223	nitrite transmembrane transporter activity
HRR99_13450	COG3852	Histidine kinase
HRR99_13455	COG2204	response regulator
HRR99_13460	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HRR99_13465	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HRR99_13470	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HRR99_13475	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HRR99_13480	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HRR99_13485	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HRR99_13500	COG4974	Belongs to the 'phage' integrase family
HRR99_13520	COG1280	lysine exporter protein (LysE YggA)
HRR99_13530	COG0508	dehydrogenase complex catalyzes the overall conversion of
HRR99_13540	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HRR99_13545	COG0045	succinate-CoA ligase (ADP-forming) activity
HRR99_13550	COG0039	L-malate dehydrogenase activity
HRR99_13555	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HRR99_13585	COG2264	protein methyltransferase activity
HRR99_13600	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HRR99_13605	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HRR99_13610	COG0181	hydroxymethylbilane synthase activity
HRR99_13640	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HRR99_13650	COG2301	Belongs to the HpcH HpaI aldolase family
HRR99_13665	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HRR99_13670	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HRR99_13675	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HRR99_13680	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HRR99_13685	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HRR99_13690	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HRR99_13695	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HRR99_13700	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HRR99_13705	COG0799	negative regulation of ribosome biogenesis
HRR99_13710	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
HRR99_13720	COG0793	Belongs to the peptidase S41A family
HRR99_13730	COG0494	nUDIX hydrolase
HRR99_13740	COG1028	Short-chain dehydrogenase reductase Sdr
HRR99_13750	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
HRR99_13755	COG2270	Major facilitator Superfamily
HRR99_13760	COG2902	Dehydrogenase
HRR99_13765	COG1329	Transcriptional regulator
HRR99_13775	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
HRR99_13795	COG0488	(ABC) transporter
HRR99_13805	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
HRR99_13815	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HRR99_13820	COG0142	geranyltranstransferase activity
HRR99_13825	COG1349	DNA-binding transcription factor activity
HRR99_13830	COG2223	nitrite transmembrane transporter activity
HRR99_13835	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HRR99_13840	COG2885	chlorophyll binding
HRR99_13845	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
HRR99_13850	COG2197	response regulator
HRR99_13855	COG1132	(ABC) transporter
HRR99_13865	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HRR99_13870	COG2084	Dehydrogenase
HRR99_13875	COG1012	belongs to the aldehyde dehydrogenase family
HRR99_13890	COG1473	amidohydrolase
HRR99_13895	COG3459	Glycosyltransferase 36 associated
HRR99_13900	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HRR99_13905	COG0495	leucyl-tRNA aminoacylation
HRR99_13920	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
HRR99_13935	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HRR99_13940	COG1946	Acyl-CoA thioesterase
HRR99_13945	COG0347	Belongs to the P(II) protein family
HRR99_13950	COG0004	ammonium transporteR
HRR99_13955	COG1674	ftsk spoiiie
HRR99_13960	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
HRR99_13985	COG0745	RESPONSE REGULATOR receiver
HRR99_13995	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HRR99_14005	COG0765	amino acid transport
HRR99_14010	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HRR99_14015	COG1122	ATPase activity
HRR99_14020	COG4120	Belongs to the binding-protein-dependent transport system permease family
HRR99_14030	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HRR99_14045	COG2154	pterin-4-alpha-carbinolamine dehydratase
HRR99_14050	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HRR99_14055	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
HRR99_14065	COG4181	ATPase activity
HRR99_14070	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
HRR99_14075	COG0670	Belongs to the BI1 family
HRR99_14090	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HRR99_14095	COG4133	protoheme IX ABC transporter activity
HRR99_14100	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HRR99_14105	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HRR99_14125	COG2917	probably involved in intracellular septation
HRR99_14130	COG0552	protein localization to endoplasmic reticulum
HRR99_14135	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HRR99_14140	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HRR99_14150	COG0335	large ribosomal subunit rRNA binding
HRR99_14160	COG0336	Belongs to the RNA methyltransferase TrmD family
HRR99_14165	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HRR99_14170	COG0228	four-way junction DNA binding
HRR99_14175	COG0287	Prephenate dehydrogenase
HRR99_14175	COG1605	Chorismate mutase
HRR99_14180	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HRR99_14195	COG1280	lysine exporter protein (LysE YggA)
HRR99_14205	COG0137	argininosuccinate synthase activity
HRR99_14210	COG2814	Major facilitator Superfamily
HRR99_14220	COG0339	signal peptide processing
HRR99_14225	COG1217	gtp-binding protein TYPA
HRR99_14235	COG0066	3-isopropylmalate dehydratase activity
HRR99_14240	COG0473	3-isopropylmalate dehydrogenase activity
HRR99_14245	COG1858	cytochrome C peroxidase
HRR99_14255	COG0625	glutathione transferase activity
HRR99_14260	COG1797	cobyrinic acid a,c-diamide synthase activity
HRR99_14265	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
HRR99_14330	COG1492	cobalamin metabolic process
HRR99_14345	COG4948	Mandelate Racemase Muconate Lactonizing
HRR99_14350	COG1063	alcohol dehydrogenase
HRR99_14370	COG4214	carbohydrate transport
HRR99_14375	COG1129	ABC transporter
HRR99_14380	COG2186	Transcriptional regulator
HRR99_14385	COG2721	sulfolactate sulfo-lyase activity
HRR99_14390	COG0138	bifunctional purine biosynthesis protein purh
HRR99_14400	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HRR99_14400	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HRR99_14405	COG0501	Belongs to the peptidase M48B family
HRR99_14425	COG0357	Ribosomal RNA small subunit methyltransferase G
HRR99_14430	COG0445	tRNA wobble uridine modification
HRR99_14435	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HRR99_14440	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HRR99_14445	COG1981	membrane
HRR99_14450	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HRR99_14455	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
HRR99_14460	COG0424	maF-like protein
HRR99_14465	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HRR99_14470	COG0237	dephospho-CoA kinase activity
HRR99_14475	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HRR99_14480	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
HRR99_14485	COG3030	protein affecting phage T7 exclusion by the F plasmid
HRR99_14520	COG0179	Fumarylacetoacetate (FAA) hydrolase
HRR99_14535	COG0135	phosphoribosylanthranilate isomerase activity
HRR99_14540	COG0133	tryptophan synthase activity
HRR99_14545	COG0159	tryptophan synthase activity
HRR99_14550	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HRR99_14575	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HRR99_14580	COG3178	'Phosphotransferase
HRR99_14585	COG2205	protein histidine kinase activity
HRR99_14590	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
HRR99_14595	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HRR99_14600	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HRR99_14600	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HRR99_14605	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
HRR99_14610	COG0642	Histidine kinase
HRR99_14615	COG0745	RESPONSE REGULATOR receiver
HRR99_14620	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
HRR99_14630	COG1072	(Pantothenic acid kinase))
HRR99_14635	COG0140	phosphoribosyl-ATP diphosphatase activity
HRR99_14640	COG0107	imidazoleglycerol-phosphate synthase activity
HRR99_14645	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HRR99_14650	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HRR99_14660	COG0131	Imidazoleglycerol-phosphate dehydratase
HRR99_14665	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
HRR99_14670	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
HRR99_14680	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HRR99_14695	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
HRR99_14705	COG1643	Atp-dependent helicase
HRR99_14710	COG2423	ornithine cyclodeaminase activity
HRR99_14745	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HRR99_14750	COG0406	alpha-ribazole phosphatase activity
HRR99_14765	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
HRR99_14770	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HRR99_14775	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
HRR99_14780	COG0295	cytidine deaminase activity
HRR99_14785	COG1079	Belongs to the binding-protein-dependent transport system permease family
HRR99_14790	COG1079	Belongs to the binding-protein-dependent transport system permease family
HRR99_14795	COG3845	ABC transporter
HRR99_14800	COG1744	ABC transporter substrate-binding protein PnrA-like
HRR99_14805	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HRR99_14840	COG0529	Catalyzes the synthesis of activated sulfate
HRR99_14845	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HRR99_14870	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HRR99_14885	COG1185	polyribonucleotide nucleotidyltransferase activity
HRR99_14890	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HRR99_14895	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HRR99_14900	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HRR99_14905	COG3064	Membrane
HRR99_14905	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HRR99_14920	COG0779	Required for maturation of 30S ribosomal subunits
HRR99_14925	COG2814	Major facilitator Superfamily
HRR99_14930	COG4191	Histidine kinase
HRR99_14930	COG0784	Response regulator, receiver
HRR99_14940	COG1136	(ABC) transporter
HRR99_14950	COG1785	Belongs to the alkaline phosphatase family
HRR99_14955	COG0443	Heat shock 70 kDa protein
HRR99_14960	COG0484	heat shock protein binding
HRR99_14975	COG2900	Belongs to the SlyX family
HRR99_15005	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HRR99_15015	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HRR99_15015	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HRR99_15025	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HRR99_15030	COG1278	Cold shock
HRR99_15035	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HRR99_15040	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HRR99_15045	COG3474	cytochrome
HRR99_15050	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
HRR99_15055	COG0077	Prephenate dehydratase
HRR99_15055	COG1605	Chorismate mutase
HRR99_15060	COG2816	NAD+ diphosphatase activity
HRR99_15075	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HRR99_15080	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HRR99_15090	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HRR99_15095	COG2951	lytic endotransglycosylase activity
HRR99_15100	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HRR99_15105	COG2226	methyltransferase
HRR99_15110	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HRR99_15115	COG1024	Enoyl-CoA hydratase
HRR99_15120	COG0268	Binds directly to 16S ribosomal RNA
HRR99_15145	COG0328	RNA-DNA hybrid ribonuclease activity
HRR99_15175	COG4297	protein containing double-stranded beta helix domain
HRR99_15195	COG1396	sequence-specific DNA binding
HRR99_15215	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HRR99_15230	COG3706	GGDEF domain
HRR99_15240	COG0784	Response regulator, receiver
HRR99_15240	COG4191	Histidine kinase
HRR99_15245	COG0840	transmembrane signaling receptor activity
HRR99_15270	COG1609	Transcriptional regulator
HRR99_15275	COG0673	inositol 2-dehydrogenase activity
HRR99_15285	COG1653	transport
HRR99_15290	COG1175	transmembrane transport
HRR99_15295	COG0395	ABC-type sugar transport system, permease component
HRR99_15300	COG3842	ATPase activity
HRR99_15305	COG0445	tRNA wobble uridine modification
HRR99_15310	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HRR99_15340	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HRR99_15345	COG1063	alcohol dehydrogenase
HRR99_15360	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HRR99_15370	COG0747	negative chemotaxis
HRR99_15390	COG0577	efflux transmembrane transporter activity
HRR99_15395	COG1136	(ABC) transporter
HRR99_15400	COG2186	Transcriptional regulator
HRR99_15415	COG1175	transmembrane transport
HRR99_15420	COG0395	ABC-type sugar transport system, permease component
HRR99_15425	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
HRR99_15470	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HRR99_15485	COG0297	glycogen (starch) synthase activity
HRR99_15490	COG4106	trans-aconitate 2-methyltransferase activity
HRR99_15495	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HRR99_15540	COG4702	Belongs to the UPF0303 family
HRR99_15560	COG2186	Transcriptional regulator
HRR99_15570	COG0765	amino acid transport
HRR99_15575	COG1126	abc transporter atp-binding protein
HRR99_15590	COG1228	amidohydrolase
HRR99_15600	COG1802	Transcriptional regulator
HRR99_15605	COG0747	negative chemotaxis
HRR99_15615	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HRR99_15625	COG0402	S-adenosylhomocysteine deaminase activity
HRR99_15630	COG0444	Belongs to the ABC transporter superfamily
HRR99_15635	COG4608	Belongs to the ABC transporter superfamily
HRR99_15650	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HRR99_15655	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HRR99_15660	COG2080	2 iron, 2 sulfur cluster binding
HRR99_15665	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
HRR99_15670	COG1309	transcriptional regulator
HRR99_15685	COG0765	amino acid transport
HRR99_15690	COG1126	abc transporter atp-binding protein
HRR99_15695	COG2079	MmgE PrpD family protein
HRR99_15700	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HRR99_15710	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HRR99_15715	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
HRR99_15725	COG0765	amino acid transport
HRR99_15730	COG0765	amino acid transport
HRR99_15735	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HRR99_15740	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HRR99_15750	COG4948	Mandelate Racemase Muconate Lactonizing
HRR99_15755	COG1028	Short-chain dehydrogenase reductase Sdr
HRR99_15760	COG1063	alcohol dehydrogenase
HRR99_15765	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
HRR99_15770	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HRR99_15785	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HRR99_15790	COG0601	transmembrane transport
HRR99_15805	COG4172	Belongs to the ABC transporter superfamily
HRR99_15810	COG1802	Transcriptional regulator
HRR99_15835	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HRR99_15840	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HRR99_15845	COG0765	amino acid transport
HRR99_15855	COG3665	Urea carboxylase-associated protein
HRR99_15870	COG0006	proline dipeptidase activity
HRR99_15885	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HRR99_15890	COG1802	Transcriptional regulator
HRR99_15895	COG1984	allophanate hydrolase subunit 2
HRR99_15900	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HRR99_15915	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HRR99_15925	COG0765	amino acid transport
HRR99_15930	COG0765	amino acid transport
HRR99_15960	COG1902	pentaerythritol trinitrate reductase activity
HRR99_15965	COG0640	Transcriptional regulator
HRR99_15975	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HRR99_16000	COG1609	Transcriptional regulator
HRR99_16010	COG0583	DNA-binding transcription factor activity
HRR99_16015	COG2814	Major facilitator Superfamily
HRR99_16020	COG4774	siderophore transport
HRR99_16040	COG1473	amidohydrolase
HRR99_16045	COG4172	Belongs to the ABC transporter superfamily
HRR99_16050	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HRR99_16055	COG0601	transmembrane transport
HRR99_16060	COG0747	negative chemotaxis
HRR99_16065	COG1414	Transcriptional regulator
HRR99_16080	COG1028	Short-chain dehydrogenase reductase Sdr
HRR99_16085	COG3181	Tripartite tricarboxylate transporter family receptor
HRR99_16110	COG1335	isochorismatase
HRR99_16120	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HRR99_16125	COG1609	Transcriptional regulator
HRR99_16130	COG2211	Major facilitator Superfamily
HRR99_16145	COG1172	Belongs to the binding-protein-dependent transport system permease family
HRR99_16155	COG0154	amidase activity
HRR99_16170	COG3201	nicotinamide mononucleotide transporter
HRR99_16190	COG1176	ABC-type spermidine putrescine transport system, permease component I
HRR99_16195	COG1177	transmembrane transport
HRR99_16210	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HRR99_16230	COG2211	Major facilitator Superfamily
HRR99_16250	COG2814	Major facilitator Superfamily
HRR99_16255	COG1250	3-hydroxyacyl-CoA dehydrogenase
HRR99_16280	COG3976	FMN-binding domain protein
HRR99_16280	COG0431	NADPH-dependent FMN reductase
HRR99_16280	COG1053	succinate dehydrogenase
HRR99_16295	COG1137	ATPase activity
HRR99_16320	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HRR99_16355	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
HRR99_16370	COG0584	glycerophosphoryl diester phosphodiesterase
HRR99_16375	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HRR99_16385	COG4608	Belongs to the ABC transporter superfamily
HRR99_16410	COG3842	ATPase activity
HRR99_16415	COG1175	transmembrane transport
HRR99_16430	COG1609	Transcriptional regulator
HRR99_16455	COG1879	ABC-type sugar transport system periplasmic component
HRR99_16460	COG1129	ABC transporter
HRR99_16465	COG1172	Belongs to the binding-protein-dependent transport system permease family
HRR99_16475	COG3386	PFAM SMP-30 Gluconolaconase
HRR99_16480	COG1120	ATPase activity
HRR99_16510	COG3842	ATPase activity
HRR99_16515	COG0395	ABC-type sugar transport system, permease component
HRR99_16520	COG1175	transmembrane transport
HRR99_16525	COG1653	transport
HRR99_16555	COG0683	leucine binding
HRR99_16565	COG0559	Belongs to the binding-protein-dependent transport system permease family
HRR99_16585	COG0745	RESPONSE REGULATOR receiver
HRR99_16590	COG1840	ABC-type Fe3 transport system, periplasmic component
HRR99_16595	COG1840	ABC-type Fe3 transport system, periplasmic component
HRR99_16605	COG3842	ATPase activity
HRR99_16620	COG4178	(ABC) transporter
HRR99_16635	COG5001	Diguanylate cyclase
HRR99_16640	COG0793	Belongs to the peptidase S41A family
HRR99_16650	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HRR99_16675	COG0438	transferase activity, transferring glycosyl groups
HRR99_16685	COG0489	protein tyrosine kinase activity
HRR99_16685	COG3206	protein involved in exopolysaccharide biosynthesis
HRR99_16710	COG0659	secondary active sulfate transmembrane transporter activity
HRR99_16730	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HRR99_16735	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HRR99_16740	COG2080	2 iron, 2 sulfur cluster binding
HRR99_16755	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
HRR99_16755	COG3608	succinylglutamate desuccinylase aspartoacylase
HRR99_16765	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HRR99_16765	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HRR99_16770	COG0523	cobalamin synthesis protein
HRR99_16775	COG1940	carbohydrate kinase activity
HRR99_16780	COG1473	amidohydrolase
HRR99_16785	COG1126	abc transporter atp-binding protein
HRR99_16790	COG0765	amino acid transport
HRR99_16810	COG0747	negative chemotaxis
HRR99_16815	COG0601	transmembrane transport
HRR99_16825	COG3964	amidohydrolase
HRR99_16840	COG1921	L-seryl-tRNASec selenium transferase activity
HRR99_16845	COG4172	Belongs to the ABC transporter superfamily
HRR99_16855	COG4529	Protein conserved in bacteria
HRR99_16875	COG1653	transport
HRR99_16880	COG1175	transmembrane transport
HRR99_16885	COG0395	ABC-type sugar transport system, permease component
HRR99_16915	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HRR99_16920	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HRR99_16930	COG1653	transport
HRR99_16935	COG1175	transmembrane transport
HRR99_16940	COG0395	ABC-type sugar transport system, permease component
HRR99_16945	COG3842	ATPase activity
HRR99_16955	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HRR99_16985	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HRR99_16990	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HRR99_17000	COG4974	Belongs to the 'phage' integrase family
HRR99_17005	COG0825	malonyl-CoA metabolic process
HRR99_17010	COG2205	protein histidine kinase activity
HRR99_17025	COG1376	ErfK ybiS ycfS ynhG family protein
HRR99_17040	COG2094	Belongs to the DNA glycosylase MPG family
HRR99_17045	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HRR99_17050	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HRR99_17060	COG1802	Transcriptional regulator
HRR99_17065	COG1028	Short-chain dehydrogenase reductase Sdr
HRR99_17075	COG3842	ATPase activity
HRR99_17080	COG1176	ABC-type spermidine putrescine transport system, permease component I
HRR99_17085	COG1177	transmembrane transport
HRR99_17100	COG0628	permease
HRR99_17110	COG1686	Belongs to the peptidase S11 family
HRR99_17115	COG0673	inositol 2-dehydrogenase activity
HRR99_17120	COG4221	oxidoreductase activity
HRR99_17130	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HRR99_17140	COG0539	negative regulation of cytoplasmic translation
HRR99_17145	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HRR99_17165	COG2890	protein-(glutamine-N5) methyltransferase activity
HRR99_17170	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HRR99_17180	COG0527	aspartate kinase activity
HRR99_17185	COG0513	Belongs to the DEAD box helicase family
HRR99_17195	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HRR99_17205	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HRR99_17220	COG2226	methyltransferase
HRR99_17230	COG3920	Histidine kinase
HRR99_17230	COG2202	Pas domain
HRR99_17265	COG0673	inositol 2-dehydrogenase activity
HRR99_17295	COG1250	3-hydroxyacyl-CoA dehydrogenase
HRR99_17295	COG1024	Enoyl-CoA hydratase
HRR99_17315	COG1832	CoA-binding protein
HRR99_17325	COG0583	DNA-binding transcription factor activity
HRR99_17345	COG0559	Belongs to the binding-protein-dependent transport system permease family
HRR99_17355	COG1064	alcohol dehydrogenase
HRR99_17370	COG0745	RESPONSE REGULATOR receiver
HRR99_17385	COG1162	GTPase activity
HRR99_17410	COG1595	DNA-templated transcription, initiation
HRR99_17435	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HRR99_17440	COG4605	iron ion homeostasis
HRR99_17445	COG4604	ABC transporter, ATP-binding protein
HRR99_17450	COG2116	formate transmembrane transporter activity
HRR99_17475	COG2010	Cytochrome c
HRR99_17475	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HRR99_17480	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HRR99_17540	COG0745	RESPONSE REGULATOR receiver
HRR99_17545	COG2205	protein histidine kinase activity
HRR99_17570	COG3046	protein related to deoxyribodipyrimidine photolyase
HRR99_17575	COG0765	amino acid transport
HRR99_17580	COG0765	amino acid transport
HRR99_17585	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HRR99_17590	COG1126	abc transporter atp-binding protein
HRR99_17595	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HRR99_17605	COG1082	Xylose isomerase domain protein TIM barrel
HRR99_17605	COG3185	4-Hydroxyphenylpyruvate dioxygenase
HRR99_17615	COG4770	biotin carboxylase activity
HRR99_17620	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HRR99_17625	COG4336	lyase activity
HRR99_17630	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
HRR99_17635	COG1914	H( )-stimulated, divalent metal cation uptake system
HRR99_17640	COG1802	Transcriptional regulator
HRR99_17645	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
HRR99_17650	COG0288	reversible hydration of carbon dioxide
HRR99_17660	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HRR99_17670	COG0246	Mannitol dehydrogenase
HRR99_17675	COG1312	Catalyzes the dehydration of D-mannonate
HRR99_17680	COG1063	alcohol dehydrogenase
HRR99_17685	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HRR99_17695	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HRR99_17700	COG2186	Transcriptional regulator
HRR99_17715	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HRR99_17720	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HRR99_17725	COG1120	ATPase activity
HRR99_17735	COG1012	belongs to the aldehyde dehydrogenase family
HRR99_17750	COG2207	Transcriptional regulator
HRR99_17755	COG4774	siderophore transport
HRR99_17765	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HRR99_17770	COG1120	ATPase activity
HRR99_17780	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HRR99_17785	COG0720	synthase
HRR99_17790	COG0602	queuosine metabolic process
HRR99_17795	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HRR99_17795	COG0425	Belongs to the sulfur carrier protein TusA family
HRR99_17815	COG0673	inositol 2-dehydrogenase activity
HRR99_17830	COG0395	ABC-type sugar transport system, permease component
HRR99_17835	COG1175	transmembrane transport
HRR99_17855	COG0643	Histidine kinase
HRR99_17855	COG2198	Histidine kinase
HRR99_17860	COG0835	chemotaxis
HRR99_17865	COG0840	transmembrane signaling receptor activity
HRR99_17870	COG0840	transmembrane signaling receptor activity
HRR99_17875	COG0840	transmembrane signaling receptor activity
HRR99_17880	COG0835	chemotaxis
HRR99_17885	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HRR99_17890	COG2201	protein-glutamate methylesterase activity
HRR99_17895	COG1192	Involved in chromosome partitioning
HRR99_17930	COG0582	viral genome integration into host DNA
HRR99_17965	COG0210	DNA helicase
HRR99_18015	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HRR99_18055	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
HRR99_18065	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HRR99_18120	COG0189	ligase activity
HRR99_18125	COG4953	penicillin-binding protein 1C
HRR99_18130	COG2373	Large extracellular alpha-helical protein
HRR99_18135	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
HRR99_18150	COG2835	tetraacyldisaccharide 4'-kinase activity
HRR99_18180	COG1686	Belongs to the peptidase S11 family
HRR99_18185	COG1309	transcriptional regulator
HRR99_18200	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HRR99_18210	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HRR99_18215	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HRR99_18220	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HRR99_18230	COG2186	Transcriptional regulator
HRR99_18235	COG0277	FAD linked oxidase domain protein
HRR99_18240	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HRR99_18245	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HRR99_18250	COG3842	ATPase activity
HRR99_18255	COG0673	inositol 2-dehydrogenase activity
HRR99_18265	COG0395	ABC-type sugar transport system, permease component
HRR99_18270	COG1175	transmembrane transport
HRR99_18275	COG1653	transport
HRR99_18280	COG1309	transcriptional regulator
HRR99_18285	COG0673	inositol 2-dehydrogenase activity
HRR99_18320	COG0697	spore germination
HRR99_18325	COG2423	ornithine cyclodeaminase activity
HRR99_18330	COG0010	Belongs to the arginase family
HRR99_18340	COG3454	Phosphonate metabolism
HRR99_18345	COG3639	organic phosphonate transmembrane transporter activity
HRR99_18350	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
HRR99_18355	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
HRR99_18365	COG4778	phosphonate C-P lyase system protein PhnL
HRR99_18370	COG4107	phosphonate C-P lyase system protein PhnK
HRR99_18375	COG3627	carbon phosphorus lyase activity
HRR99_18380	COG3626	phosphonate metabolism
HRR99_18385	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
HRR99_18390	COG3624	Phosphonate C-P lyase system protein PhnG
HRR99_18395	COG2188	Transcriptional regulator
HRR99_18405	COG1879	ABC-type sugar transport system periplasmic component
HRR99_18415	COG1172	Belongs to the binding-protein-dependent transport system permease family
HRR99_18430	COG1028	Short-chain dehydrogenase reductase Sdr
HRR99_18435	COG1028	Short-chain dehydrogenase reductase Sdr
HRR99_18440	COG2197	response regulator
HRR99_18445	COG3237	CsbD-like
HRR99_18465	COG0657	acetylesterase activity
HRR99_18480	COG3142	Participates in the control of copper homeostasis
HRR99_18490	COG0673	inositol 2-dehydrogenase activity
HRR99_18495	COG0395	ABC-type sugar transport system, permease component
HRR99_18500	COG1175	transmembrane transport
HRR99_18505	COG1653	transport
HRR99_18510	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HRR99_18515	COG2971	BadF BadG BcrA BcrD
HRR99_18520	COG2188	Transcriptional regulator
HRR99_18525	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HRR99_18530	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HRR99_18540	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HRR99_18555	COG1309	transcriptional regulator
HRR99_18560	COG2124	cytochrome p450
HRR99_18585	COG2884	Cell division ATP-binding protein ftsE
HRR99_18605	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
HRR99_18615	COG0287	Prephenate dehydrogenase
HRR99_18620	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HRR99_18625	COG2226	methyltransferase
HRR99_18630	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HRR99_18645	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HRR99_18650	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
HRR99_18655	COG1396	sequence-specific DNA binding
HRR99_18705	COG1960	acyl-CoA dehydrogenase activity
HRR99_18710	COG0446	pyridine nucleotide-disulphide oxidoreductase
HRR99_18710	COG1902	pentaerythritol trinitrate reductase activity
HRR99_18720	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HRR99_18730	COG4176	ABC-type proline glycine betaine transport system permease component
HRR99_18735	COG4175	Glycine betaine
HRR99_18735	COG0517	IMP dehydrogenase activity
HRR99_18740	COG3685	Protein conserved in bacteria
HRR99_18750	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
HRR99_18785	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HRR99_18795	COG0300	oxidoreductase activity
HRR99_18815	COG2086	electron transfer activity
HRR99_18825	COG1250	3-hydroxyacyl-CoA dehydrogenase
HRR99_18830	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HRR99_18835	COG0165	Argininosuccinate lyase
HRR99_18865	COG0318	PFAM AMP-dependent synthetase and ligase
HRR99_18875	COG1802	Transcriptional regulator
HRR99_18880	COG3483	tryptophan 2,3-dioxygenase activity
HRR99_18890	COG0300	oxidoreductase activity
HRR99_18905	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
HRR99_18910	COG1846	Transcriptional regulator
HRR99_18925	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HRR99_18940	COG0747	negative chemotaxis
HRR99_18945	COG2866	Carboxypeptidase
HRR99_18985	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HRR99_18995	COG2814	Major facilitator Superfamily
HRR99_19015	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HRR99_19035	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HRR99_19040	COG0765	amino acid transport
HRR99_19050	COG0747	negative chemotaxis
HRR99_19055	COG0601	transmembrane transport
HRR99_19060	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HRR99_19065	COG0444	Belongs to the ABC transporter superfamily
HRR99_19070	COG4608	Belongs to the ABC transporter superfamily
HRR99_19075	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HRR99_19085	COG0436	Aminotransferase
HRR99_19090	COG0277	FAD linked oxidase domain protein
HRR99_19100	COG1028	Short-chain dehydrogenase reductase Sdr
HRR99_19120	COG0179	Fumarylacetoacetate (FAA) hydrolase
HRR99_19130	COG1846	Transcriptional regulator
HRR99_19175	COG1653	transport
HRR99_19205	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
HRR99_19230	COG1414	Transcriptional regulator
HRR99_19235	COG1475	DNA binding
HRR99_19240	COG1192	Involved in chromosome partitioning
HRR99_19250	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HRR99_19260	COG3206	protein involved in exopolysaccharide biosynthesis
HRR99_19260	COG0489	protein tyrosine kinase activity
HRR99_19295	COG0438	transferase activity, transferring glycosyl groups
HRR99_19305	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HRR99_19310	COG1335	isochorismatase
HRR99_19315	COG0251	oxidation-reduction process
HRR99_19320	COG2267	carboxylic ester hydrolase activity
HRR99_19325	COG0778	Nitroreductase
HRR99_19330	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HRR99_19350	COG2390	Transcriptional regulator
HRR99_19355	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HRR99_19360	COG3958	Transketolase
HRR99_19365	COG3959	Transketolase, thiamine diphosphate binding domain
HRR99_19370	COG1172	Belongs to the binding-protein-dependent transport system permease family
HRR99_19380	COG1129	ABC transporter
HRR99_19385	COG1028	Short-chain dehydrogenase reductase Sdr
HRR99_19405	COG3920	Histidine kinase
HRR99_19415	COG0583	DNA-binding transcription factor activity
HRR99_19420	COG2855	membrane
HRR99_19430	COG4989	oxidoreductase activity
HRR99_19440	COG2188	Transcriptional regulator
HRR99_19445	COG3842	ATPase activity
HRR99_19450	COG1653	transport
HRR99_19455	COG1175	transmembrane transport
HRR99_19460	COG0395	ABC-type sugar transport system, permease component
HRR99_19465	COG1501	Belongs to the glycosyl hydrolase 31 family
HRR99_19475	COG1082	Xylose isomerase domain protein TIM barrel
HRR99_19490	COG1172	Belongs to the binding-protein-dependent transport system permease family
HRR99_19495	COG1172	Belongs to the binding-protein-dependent transport system permease family
HRR99_19500	COG1129	ABC transporter
HRR99_19575	COG0604	alcohol dehydrogenase
HRR99_19580	COG1028	Short-chain dehydrogenase reductase Sdr
HRR99_19585	COG1902	pentaerythritol trinitrate reductase activity
HRR99_19590	COG4221	oxidoreductase activity
HRR99_19595	COG1309	transcriptional regulator
HRR99_19605	COG1566	PFAM secretion protein HlyD family protein
HRR99_19645	COG3181	Tripartite tricarboxylate transporter family receptor
HRR99_19685	COG3209	COG3209 Rhs family protein
HRR99_19765	COG1278	Cold shock
HRR99_19785	COG1733	regulation of RNA biosynthetic process
HRR99_19815	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HRR99_19830	COG0747	negative chemotaxis
HRR99_19835	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HRR99_19840	COG0601	transmembrane transport
HRR99_19845	COG0583	DNA-binding transcription factor activity
HRR99_19860	COG3920	Histidine kinase
HRR99_19885	COG0657	acetylesterase activity
HRR99_19890	COG0583	DNA-binding transcription factor activity
HRR99_19930	COG3842	ATPase activity
HRR99_19935	COG4149	molybdate abc transporter
HRR99_19945	COG0584	glycerophosphoryl diester phosphodiesterase
HRR99_19950	COG0483	inositol monophosphate 1-phosphatase activity
HRR99_19965	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HRR99_19975	COG1597	lipid kinase activity
HRR99_19980	COG2354	Protein conserved in bacteria
HRR99_19985	COG2186	Transcriptional regulator
HRR99_19995	COG0765	amino acid transport
HRR99_20010	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HRR99_20020	COG1177	transmembrane transport
HRR99_20030	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HRR99_20065	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HRR99_20085	COG1609	Transcriptional regulator
HRR99_20090	COG0395	ABC-type sugar transport system, permease component
HRR99_20095	COG1175	transmembrane transport
HRR99_20110	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
HRR99_20125	COG1653	transport
HRR99_20130	COG1175	transmembrane transport
HRR99_20135	COG0395	ABC-type sugar transport system, permease component
HRR99_20140	COG3842	ATPase activity
HRR99_20150	COG1312	Catalyzes the dehydration of D-mannonate
HRR99_20160	COG2186	Transcriptional regulator
HRR99_20165	COG1126	abc transporter atp-binding protein
HRR99_20180	COG0765	amino acid transport
HRR99_20190	COG3684	Belongs to the aldolase LacD family
HRR99_20200	COG0673	inositol 2-dehydrogenase activity
HRR99_20220	COG0395	ABC-type sugar transport system, permease component
HRR99_20225	COG1175	transmembrane transport
HRR99_20235	COG0657	acetylesterase activity
HRR99_20245	COG3842	ATPase activity
HRR99_20255	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HRR99_20260	COG1116	anion transmembrane transporter activity
HRR99_20265	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HRR99_20275	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HRR99_20280	COG1028	Short-chain dehydrogenase reductase Sdr
HRR99_20285	COG4948	Mandelate Racemase Muconate Lactonizing
HRR99_20290	COG1082	Xylose isomerase domain protein TIM barrel
HRR99_20300	COG1802	Transcriptional regulator
HRR99_20310	COG1175	transmembrane transport
HRR99_20315	COG0395	ABC-type sugar transport system, permease component
HRR99_20320	COG3842	ATPase activity
HRR99_20330	COG3842	ATPase activity
HRR99_20340	COG1175	transmembrane transport
HRR99_20345	COG0395	ABC-type sugar transport system, permease component
HRR99_20365	COG1129	ABC transporter
HRR99_20370	COG1172	Belongs to the binding-protein-dependent transport system permease family
HRR99_20375	COG1737	Transcriptional regulator
HRR99_20390	COG0745	RESPONSE REGULATOR receiver
HRR99_20405	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HRR99_20415	COG2076	Multidrug Resistance protein
HRR99_20425	COG1647	Serine aminopeptidase, S33
HRR99_20435	COG2076	Multidrug Resistance protein
HRR99_20450	COG0395	ABC-type sugar transport system, permease component
HRR99_20455	COG1175	transmembrane transport
HRR99_20460	COG3842	ATPase activity
HRR99_20475	COG2217	Heavy metal translocating P-type atpase
HRR99_20485	COG1999	signal sequence binding
HRR99_20495	COG1120	ATPase activity
HRR99_20500	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HRR99_20515	COG2226	methyltransferase
HRR99_20520	COG0542	response to heat
HRR99_20525	COG1196	nuclear chromosome segregation
HRR99_20525	COG0741	lytic transglycosylase activity
HRR99_20525	COG0739	heme binding
HRR99_20585	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HRR99_20595	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HRR99_20625	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HRR99_20640	COG1215	transferase activity, transferring glycosyl groups
HRR99_20660	COG4372	Transposase
HRR99_20665	COG4372	Transposase
HRR99_20725	COG0784	Response regulator, receiver
HRR99_20725	COG4191	Histidine kinase
HRR99_20730	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HRR99_20765	COG0673	inositol 2-dehydrogenase activity
HRR99_20775	COG1063	alcohol dehydrogenase
HRR99_20780	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HRR99_20785	COG0747	negative chemotaxis
HRR99_20790	COG0601	transmembrane transport
HRR99_20795	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HRR99_20800	COG0444	Belongs to the ABC transporter superfamily
HRR99_20805	COG4608	Belongs to the ABC transporter superfamily
HRR99_20830	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HRR99_20835	COG0601	transmembrane transport
HRR99_20840	COG0747	negative chemotaxis
HRR99_20865	COG1442	glycosyl transferase family 8
HRR99_20870	COG0653	protein targeting
HRR99_20875	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HRR99_20880	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HRR99_20890	COG0494	nUDIX hydrolase
HRR99_20905	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HRR99_20930	COG5001	Diguanylate cyclase
HRR99_20935	COG2264	protein methyltransferase activity
HRR99_20940	COG4608	Belongs to the ABC transporter superfamily
HRR99_20945	COG0444	Belongs to the ABC transporter superfamily
HRR99_20950	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HRR99_20955	COG0601	transmembrane transport
HRR99_20960	COG2186	Transcriptional regulator
HRR99_20970	COG4618	COG4618 ABC-type protease lipase transport system, ATPase and permease components
HRR99_20975	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HRR99_21005	COG2194	sulfuric ester hydrolase activity
HRR99_21020	COG2133	pyrroloquinoline quinone binding
HRR99_21030	COG0500	methyltransferase
HRR99_21035	COG0564	pseudouridine synthase activity
HRR99_21050	COG0784	Response regulator, receiver
HRR99_21050	COG4191	Histidine kinase
HRR99_21055	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HRR99_21060	COG0489	protein tyrosine kinase activity
HRR99_21060	COG3206	protein involved in exopolysaccharide biosynthesis
HRR99_21065	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HRR99_21070	COG1215	transferase activity, transferring glycosyl groups
HRR99_21075	COG1215	transferase activity, transferring glycosyl groups
HRR99_21080	COG1215	transferase activity, transferring glycosyl groups
HRR99_21085	COG0438	transferase activity, transferring glycosyl groups
HRR99_21090	COG2273	Hydrolase Family 16
HRR99_21095	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HRR99_21100	COG2244	polysaccharide biosynthetic process
HRR99_21105	COG0463	Glycosyl transferase, family 2
HRR99_21110	COG2327	Polysaccharide pyruvyl transferase
HRR99_21115	COG1215	transferase activity, transferring glycosyl groups
HRR99_21130	COG1609	Transcriptional regulator
HRR99_21135	COG1129	ABC transporter
HRR99_21140	COG1172	Belongs to the binding-protein-dependent transport system permease family
HRR99_21145	COG1879	ABC-type sugar transport system periplasmic component
HRR99_21150	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HRR99_21155	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HRR99_21160	COG0280	phosphate acetyltransferase
HRR99_21160	COG0281	malic enzyme
HRR99_21180	COG2137	regulation of response to DNA damage stimulus
HRR99_21195	COG2942	2-epimerase
HRR99_21205	COG1215	transferase activity, transferring glycosyl groups
HRR99_21225	COG1959	2 iron, 2 sulfur cluster binding
HRR99_21240	COG1301	dicarboxylic acid transport
HRR99_21245	COG4191	Histidine kinase
HRR99_21250	COG2204	response regulator
HRR99_21265	COG1178	ABC-type Fe3 transport system permease component
HRR99_21280	COG3842	ATPase activity
HRR99_21290	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HRR99_21295	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HRR99_21300	COG1522	sequence-specific DNA binding
HRR99_21305	COG0351	phosphomethylpyrimidine kinase
HRR99_21310	COG0352	thiamine-phosphate diphosphorylase activity
HRR99_21315	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
HRR99_21320	COG0673	inositol 2-dehydrogenase activity
HRR99_21360	COG4770	biotin carboxylase activity
HRR99_21365	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HRR99_21370	COG1126	abc transporter atp-binding protein
HRR99_21375	COG0765	amino acid transport
HRR99_21380	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HRR99_21385	COG0850	regulation of cytokinetic process
HRR99_21390	COG2894	cell division
HRR99_21395	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
HRR99_21400	COG2223	nitrite transmembrane transporter activity
HRR99_21410	COG0583	DNA-binding transcription factor activity
HRR99_21420	COG3119	arylsulfatase activity
HRR99_21440	COG0515	serine threonine protein kinase
HRR99_21530	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HRR99_21535	COG3842	ATPase activity
HRR99_21540	COG0395	ABC-type sugar transport system, permease component
HRR99_21545	COG1175	transmembrane transport
HRR99_21560	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HRR99_21570	COG5001	Diguanylate cyclase
HRR99_21570	COG3300	MHYT domain
HRR99_21580	COG3257	ureidoglycine aminohydrolase activity
HRR99_21585	COG3447	MASE1 domain protein
HRR99_21585	COG5001	Diguanylate cyclase
HRR99_21585	COG5002	protein histidine kinase activity
HRR99_21590	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
HRR99_21590	COG2273	Hydrolase Family 16
HRR99_21600	COG0372	Belongs to the citrate synthase family
HRR99_21605	COG0372	Belongs to the citrate synthase family
HRR99_21620	COG1024	Enoyl-CoA hydratase
HRR99_21635	COG1960	acyl-CoA dehydrogenase activity
HRR99_21660	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HRR99_21670	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HRR99_21675	COG5001	Diguanylate cyclase
HRR99_21675	COG3300	MHYT domain
HRR99_21690	COG0183	Belongs to the thiolase family
HRR99_21695	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HRR99_21705	COG1414	Transcriptional regulator
HRR99_21720	COG0583	DNA-binding transcription factor activity
HRR99_21725	COG0596	Alpha beta hydrolase
HRR99_21730	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HRR99_21735	COG3485	protocatechuate 3,4-dioxygenase
HRR99_21740	COG3485	protocatechuate 3,4-dioxygenase
HRR99_21745	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HRR99_21755	COG0693	protein deglycase activity
HRR99_21760	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HRR99_21765	COG1596	polysaccharide export
HRR99_21770	COG3307	-O-antigen
HRR99_21785	COG0587	DNA-directed DNA polymerase activity
HRR99_21790	COG2186	Transcriptional regulator
HRR99_21795	COG1172	Belongs to the binding-protein-dependent transport system permease family
HRR99_21800	COG1172	Belongs to the binding-protein-dependent transport system permease family
HRR99_21805	COG1129	ABC transporter
HRR99_21810	COG1879	ABC-type sugar transport system periplasmic component
HRR99_21820	COG0129	dihydroxy-acid dehydratase activity
HRR99_21835	COG3145	DNA-N1-methyladenine dioxygenase activity
HRR99_21865	COG2197	response regulator
HRR99_21885	COG0488	(ABC) transporter
HRR99_21895	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HRR99_21900	COG3962	Belongs to the TPP enzyme family
HRR99_21910	COG3718	enzyme involved in inositol metabolism
HRR99_21915	COG0450	alkyl hydroperoxide reductase
HRR99_21920	COG5265	(ABC) transporter
HRR99_21925	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HRR99_21950	COG0395	ABC-type sugar transport system, permease component
HRR99_21960	COG3842	ATPase activity
HRR99_21965	COG3842	ATPase activity
HRR99_21980	COG4166	transmembrane transport
HRR99_21985	COG0601	transmembrane transport
HRR99_21990	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HRR99_21995	COG4172	Belongs to the ABC transporter superfamily
HRR99_22005	COG5001	Diguanylate cyclase
HRR99_22005	COG3300	MHYT domain
HRR99_22045	COG0477	Major facilitator Superfamily
HRR99_22070	COG0714	Associated with various cellular activities
HRR99_22075	COG2425	protein containing a von Willebrand factor type A (vWA) domain
HRR99_22085	COG3552	Protein containing von Willebrand factor type A (VWA) domain
HRR99_22090	COG4715	Zinc finger, swim domain protein
HRR99_22125	COG2184	nucleotidyltransferase activity
HRR99_22155	COG1192	Involved in chromosome partitioning
HRR99_22160	COG1475	DNA binding
HRR99_22165	COG0640	Transcriptional regulator
HRR99_22170	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
HRR99_22195	COG2814	Major facilitator Superfamily
HRR99_22200	COG3831	ATPase activity
HRR99_22220	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HRR99_22225	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HRR99_22250	COG2801	Transposase and inactivated derivatives
HRR99_22260	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HRR99_22280	COG1733	regulation of RNA biosynthetic process
HRR99_22285	COG1028	Short-chain dehydrogenase reductase Sdr
HRR99_22310	COG1794	racemase activity, acting on amino acids and derivatives
HRR99_22365	COG0667	Aldo Keto reductase
HRR99_22380	COG0598	Magnesium transport protein CorA
HRR99_22385	COG1028	Short-chain dehydrogenase reductase Sdr
HRR99_22395	COG1028	Short-chain dehydrogenase reductase Sdr
HRR99_22405	COG0708	Exodeoxyribonuclease III
HRR99_22440	COG0210	DNA helicase
HRR99_22450	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HRR99_22455	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HRR99_22490	COG1780	Probably involved in ribonucleotide reductase function
HRR99_22495	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HRR99_22525	COG3706	GGDEF domain
HRR99_22525	COG5001	Diguanylate cyclase
HRR99_22525	COG4251	negative regulation of phosphorylation
HRR99_22525	COG2203	Gaf domain
HRR99_22530	COG3588	fructose-bisphosphate aldolase
HRR99_22560	COG4191	Histidine kinase
HRR99_22565	COG4566	intracellular signal transduction
HRR99_22605	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HRR99_22630	COG1574	metal-dependent hydrolase with the TIM-barrel fold
HRR99_22650	COG2207	Transcriptional regulator
HRR99_22660	COG0346	lactoylglutathione lyase activity
HRR99_22665	COG0583	DNA-binding transcription factor activity
HRR99_22670	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
HRR99_22695	COG4774	siderophore transport
HRR99_22700	COG0583	DNA-binding transcription factor activity
HRR99_22720	COG2885	chlorophyll binding
HRR99_22730	COG3040	lipid binding
HRR99_22735	COG0840	transmembrane signaling receptor activity
HRR99_22740	COG0583	DNA-binding transcription factor activity
HRR99_22745	COG2828	Protein conserved in bacteria
HRR99_22760	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HRR99_22765	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
HRR99_22780	COG1309	transcriptional regulator
HRR99_22785	COG2814	Major facilitator Superfamily
HRR99_22795	COG0778	Nitroreductase
HRR99_22805	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HRR99_22815	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HRR99_22820	COG2084	Dehydrogenase
HRR99_22840	COG3077	Addiction module antitoxin, RelB DinJ family
HRR99_22860	COG0702	epimerase
HRR99_22870	COG1017	nitric oxide dioxygenase activity
HRR99_22870	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HRR99_22875	COG0625	glutathione transferase activity
HRR99_22895	COG0583	DNA-binding transcription factor activity
HRR99_22905	COG1309	transcriptional regulator
HRR99_22920	COG0596	Alpha beta hydrolase
HRR99_22975	COG0798	PFAM Bile acid sodium symporter
HRR99_22985	COG0431	NADPH-dependent FMN reductase
HRR99_22990	COG0385	Bile acid
HRR99_22995	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HRR99_23035	COG3742	Toxic component of a toxin-antitoxin (TA) module. An RNase