locus-tag	class	description
AVF2S5_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AVF2S5_00010	COG0697	spore germination
AVF2S5_00015	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AVF2S5_00020	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AVF2S5_00025	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
AVF2S5_00035	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
AVF2S5_00040	COG1420	regulation of RNA biosynthetic process
AVF2S5_00045	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AVF2S5_00050	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AVF2S5_00055	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
AVF2S5_00065	COG1137	ATPase activity
AVF2S5_00070	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
AVF2S5_00080	COG0776	regulation of translation
AVF2S5_00095	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AVF2S5_00100	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
AVF2S5_00120	COG0583	DNA-binding transcription factor activity
AVF2S5_00125	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
AVF2S5_00130	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
AVF2S5_00140	COG0346	lactoylglutathione lyase activity
AVF2S5_00145	COG0180	Tryptophanyl-tRNA synthetase
AVF2S5_00155	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
AVF2S5_00160	COG1214	PFAM Peptidase M22, glycoprotease
AVF2S5_00180	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AVF2S5_00185	COG1702	phosphate starvation-inducible protein PhoH
AVF2S5_00190	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
AVF2S5_00195	COG4535	Mg2 and Co2 transporter CorC
AVF2S5_00200	COG0815	Transfers the fatty acyl group on membrane lipoproteins
AVF2S5_00205	COG1396	sequence-specific DNA binding
AVF2S5_00210	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
AVF2S5_00215	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AVF2S5_00225	COG0071	Belongs to the small heat shock protein (HSP20) family
AVF2S5_00245	COG0840	transmembrane signaling receptor activity
AVF2S5_00255	COG2205	protein histidine kinase activity
AVF2S5_00260	COG0230	Belongs to the bacterial ribosomal protein bL34 family
AVF2S5_00265	COG0594	ribonuclease P activity
AVF2S5_00270	COG0706	membrane insertase activity
AVF2S5_00275	COG0218	Necessary for normal cell division and for the maintenance of normal septation
AVF2S5_00280	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
AVF2S5_00295	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AVF2S5_00300	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AVF2S5_00325	COG2171	N-acyltransferase activity
AVF2S5_00330	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AVF2S5_00355	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AVF2S5_00360	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AVF2S5_00370	COG0745	RESPONSE REGULATOR receiver
AVF2S5_00375	COG0704	Plays a role in the regulation of phosphate uptake
AVF2S5_00380	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AVF2S5_00390	COG0573	inorganic phosphate transmembrane transporter activity
AVF2S5_00400	COG5002	protein histidine kinase activity
AVF2S5_00405	COG2326	polyphosphate kinase activity
AVF2S5_00425	COG0517	IMP dehydrogenase activity
AVF2S5_00425	COG1125	glycine betaine transport
AVF2S5_00430	COG1174	glycine betaine transport
AVF2S5_00445	COG2188	Transcriptional regulator
AVF2S5_00450	COG2986	histidine ammonia-lyase
AVF2S5_00460	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AVF2S5_00465	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
AVF2S5_00465	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
AVF2S5_00475	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AVF2S5_00495	COG0427	acetyl-CoA hydrolase
AVF2S5_00505	COG3938	Belongs to the proline racemase family
AVF2S5_00510	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AVF2S5_00515	COG0745	RESPONSE REGULATOR receiver
AVF2S5_00535	COG0418	dihydroorotase activity
AVF2S5_00540	COG3706	GGDEF domain
AVF2S5_00545	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
AVF2S5_00555	COG1028	Short-chain dehydrogenase reductase Sdr
AVF2S5_00560	COG0166	Belongs to the GPI family
AVF2S5_00565	COG0318	PFAM AMP-dependent synthetase and ligase
AVF2S5_00580	COG1028	Short-chain dehydrogenase reductase Sdr
AVF2S5_00590	COG0101	tRNA pseudouridine synthase activity
AVF2S5_00595	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AVF2S5_00600	COG0242	peptide deformylase activity
AVF2S5_00605	COG2967	ApaG domain
AVF2S5_00615	COG0717	Belongs to the dCTP deaminase family
AVF2S5_00660	COG0250	Participates in transcription elongation, termination and antitermination
AVF2S5_00685	COG1450	Type ii and iii secretion system protein
AVF2S5_00695	COG2165	general secretion pathway protein
AVF2S5_00720	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AVF2S5_00775	COG0587	DNA-directed DNA polymerase activity
AVF2S5_00795	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AVF2S5_00820	COG0167	dihydroorotate dehydrogenase activity
AVF2S5_00840	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AVF2S5_00860	COG1250	3-hydroxyacyl-CoA dehydrogenase
AVF2S5_00860	COG1024	Enoyl-CoA hydratase
AVF2S5_00865	COG0183	Belongs to the thiolase family
AVF2S5_00870	COG1960	acyl-CoA dehydrogenase activity
AVF2S5_00890	COG1785	Belongs to the alkaline phosphatase family
AVF2S5_00900	COG1136	(ABC) transporter
AVF2S5_00915	COG5001	Diguanylate cyclase
AVF2S5_00915	COG4251	negative regulation of phosphorylation
AVF2S5_00915	COG3706	GGDEF domain
AVF2S5_00915	COG2203	Gaf domain
AVF2S5_00920	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AVF2S5_00930	COG1201	RNA secondary structure unwinding
AVF2S5_00950	COG1047	Peptidyl-prolyl cis-trans
AVF2S5_00955	COG0784	Response regulator, receiver
AVF2S5_00955	COG2198	Histidine kinase
AVF2S5_00955	COG2205	protein histidine kinase activity
AVF2S5_00960	COG1970	mechanosensitive ion channel activity
AVF2S5_00965	COG0436	Aminotransferase
AVF2S5_00970	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
AVF2S5_00990	COG1216	Glycosyl transferase, family 2
AVF2S5_01015	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
AVF2S5_01020	COG0424	maF-like protein
AVF2S5_01025	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
AVF2S5_01035	COG5328	Belongs to the UPF0262 family
AVF2S5_01040	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AVF2S5_01050	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AVF2S5_01085	COG1215	transferase activity, transferring glycosyl groups
AVF2S5_01095	COG0488	(ABC) transporter
AVF2S5_01120	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
AVF2S5_01125	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AVF2S5_01130	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AVF2S5_01135	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AVF2S5_01140	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
AVF2S5_01145	COG4786	Flagellar basal body rod
AVF2S5_01150	COG1157	protein secretion by the type III secretion system
AVF2S5_01160	COG1815	bacterial-type flagellum-dependent cell motility
AVF2S5_01165	COG1558	bacterial-type flagellum-dependent cell motility
AVF2S5_01170	COG1677	Flagellar hook-basal body complex protein FliE
AVF2S5_01175	COG4786	Flagellar basal body rod
AVF2S5_01180	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
AVF2S5_01185	COG1706	bacterial-type flagellum-dependent cell motility
AVF2S5_01195	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
AVF2S5_01205	COG1338	Plays a role in the flagellum-specific transport system
AVF2S5_01210	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AVF2S5_01215	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AVF2S5_01220	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AVF2S5_01225	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AVF2S5_01230	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AVF2S5_01240	COG1360	Flagellar Motor Protein
AVF2S5_01265	COG1749	Flagellar hook protein flgE
AVF2S5_01285	COG5443	negative regulation of bacterial-type flagellum assembly
AVF2S5_01290	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
AVF2S5_01295	COG4794	Type iii secretion
AVF2S5_01300	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
AVF2S5_01335	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AVF2S5_01340	COG1609	Transcriptional regulator
AVF2S5_01345	COG1653	transport
AVF2S5_01350	COG1175	transmembrane transport
AVF2S5_01355	COG0395	ABC-type sugar transport system, permease component
AVF2S5_01360	COG0366	Alpha amylase catalytic
AVF2S5_01365	COG3842	ATPase activity
AVF2S5_01380	COG3493	citrate carrier protein
AVF2S5_01390	COG0129	dihydroxy-acid dehydratase activity
AVF2S5_01395	COG0363	glucosamine-6-phosphate deaminase activity
AVF2S5_01400	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
AVF2S5_01405	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AVF2S5_01415	COG2081	HI0933 family
AVF2S5_01430	COG2972	Histidine kinase
AVF2S5_01430	COG0840	transmembrane signaling receptor activity
AVF2S5_01435	COG0583	DNA-binding transcription factor activity
AVF2S5_01460	COG2224	Isocitrate lyase
AVF2S5_01475	COG3842	ATPase activity
AVF2S5_01480	COG1176	ABC-type spermidine putrescine transport system, permease component I
AVF2S5_01485	COG1177	transmembrane transport
AVF2S5_01495	COG2205	protein histidine kinase activity
AVF2S5_01545	COG1959	2 iron, 2 sulfur cluster binding
AVF2S5_01550	COG3265	gluconokinase activity
AVF2S5_01555	COG2134	cdp-diacylglycerol pyrophosphatase
AVF2S5_01560	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AVF2S5_01565	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
AVF2S5_01585	COG0579	oxidoreductase
AVF2S5_01590	COG0446	pyridine nucleotide-disulphide oxidoreductase
AVF2S5_01605	COG0248	Ppx GppA phosphatase
AVF2S5_01610	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
AVF2S5_01620	COG3300	MHYT domain
AVF2S5_01620	COG5001	Diguanylate cyclase
AVF2S5_01625	COG5002	protein histidine kinase activity
AVF2S5_01625	COG0784	Response regulator, receiver
AVF2S5_01625	COG2198	Histidine kinase
AVF2S5_01630	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
AVF2S5_01640	COG1663	tetraacyldisaccharide 4'-kinase activity
AVF2S5_01650	COG1519	Transferase
AVF2S5_01660	COG1218	3'(2'),5'-bisphosphate nucleotidase
AVF2S5_01665	COG0312	modulator of DNA gyrase
AVF2S5_01670	COG0475	glutathione-regulated potassium exporter activity
AVF2S5_01670	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AVF2S5_01680	COG0742	ribosomal rna small subunit methyltransferase
AVF2S5_01685	COG1187	pseudouridine synthase activity
AVF2S5_01690	COG0590	tRNA wobble adenosine to inosine editing
AVF2S5_01700	COG0477	Major facilitator Superfamily
AVF2S5_01710	COG3386	PFAM SMP-30 Gluconolaconase
AVF2S5_01720	COG2771	luxR family
AVF2S5_01740	COG3158	transport of potassium into the cell
AVF2S5_01750	COG0356	it plays a direct role in the translocation of protons across the membrane
AVF2S5_01760	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AVF2S5_01765	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AVF2S5_01770	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AVF2S5_01785	COG0521	Mo-molybdopterin cofactor biosynthetic process
AVF2S5_01790	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
AVF2S5_01800	COG0142	geranyltranstransferase activity
AVF2S5_01810	COG4106	trans-aconitate 2-methyltransferase activity
AVF2S5_01830	COG0752	glycyl-tRNA synthetase alpha subunit
AVF2S5_01840	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
AVF2S5_01845	COG0751	glycine-tRNA ligase activity
AVF2S5_01850	COG1683	Conserved Protein
AVF2S5_01855	COG0840	transmembrane signaling receptor activity
AVF2S5_01855	COG0840	transmembrane signaling receptor activity
AVF2S5_01865	COG0151	Belongs to the GarS family
AVF2S5_01875	COG2183	response to ionizing radiation
AVF2S5_01880	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AVF2S5_01910	COG0725	ABC transporter, periplasmic molybdate-binding protein
AVF2S5_01915	COG4149	molybdate abc transporter
AVF2S5_01920	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
AVF2S5_01925	COG2005	Transcriptional regulator
AVF2S5_01925	COG3585	molybdate ion transport
AVF2S5_01935	COG0009	L-threonylcarbamoyladenylate synthase
AVF2S5_01945	COG0840	transmembrane signaling receptor activity
AVF2S5_01950	COG4638	Rieske (2fe-2S)
AVF2S5_01975	COG1960	acyl-CoA dehydrogenase activity
AVF2S5_01980	COG1024	Enoyl-CoA hydratase
AVF2S5_01990	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AVF2S5_02000	COG0840	transmembrane signaling receptor activity
AVF2S5_02005	COG0840	transmembrane signaling receptor activity
AVF2S5_02010	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
AVF2S5_02015	COG1722	exodeoxyribonuclease VII activity
AVF2S5_02020	COG0123	including yeast histone deacetylase and acetoin utilization protein
AVF2S5_02035	COG1268	BioY protein
AVF2S5_02040	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
AVF2S5_02045	COG1122	ATPase activity
AVF2S5_02055	COG3214	Protein conserved in bacteria
AVF2S5_02080	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AVF2S5_02080	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AVF2S5_02085	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
AVF2S5_02090	COG5001	Diguanylate cyclase
AVF2S5_02090	COG3300	MHYT domain
AVF2S5_02105	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
AVF2S5_02110	COG0484	heat shock protein binding
AVF2S5_02120	COG0259	pyridoxamine-phosphate oxidase activity
AVF2S5_02130	COG2814	Major facilitator Superfamily
AVF2S5_02135	COG0789	Transcriptional regulator
AVF2S5_02140	COG1686	Belongs to the peptidase S11 family
AVF2S5_02155	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AVF2S5_02165	COG0312	modulator of DNA gyrase
AVF2S5_02180	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AVF2S5_02185	COG0109	protoheme IX farnesyltransferase activity
AVF2S5_02195	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
AVF2S5_02210	COG3346	SURF1 family
AVF2S5_02220	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
AVF2S5_02230	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
AVF2S5_02235	COG0328	RNA-DNA hybrid ribonuclease activity
AVF2S5_02245	COG0803	Belongs to the bacterial solute-binding protein 9 family
AVF2S5_02260	COG0678	peroxiredoxin activity
AVF2S5_02260	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
AVF2S5_02270	COG1678	Uncharacterized ACR, COG1678
AVF2S5_02280	COG0640	Transcriptional regulator
AVF2S5_02285	COG5001	Diguanylate cyclase
AVF2S5_02290	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AVF2S5_02295	COG0612	Peptidase, M16
AVF2S5_02310	COG1597	lipid kinase activity
AVF2S5_02315	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AVF2S5_02325	COG2189	Belongs to the N(4) N(6)-methyltransferase family
AVF2S5_02355	COG1194	a g-specific adenine glycosylase
AVF2S5_02370	COG1196	nuclear chromosome segregation
AVF2S5_02385	COG2814	Major facilitator Superfamily
AVF2S5_02400	COG0574	Belongs to the PEP-utilizing enzyme family
AVF2S5_02400	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AVF2S5_02435	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AVF2S5_02455	COG0840	transmembrane signaling receptor activity
AVF2S5_02460	COG0175	sulfate reduction
AVF2S5_02465	COG0175	sulfate reduction
AVF2S5_02470	COG2895	sulfate adenylyltransferase (ATP) activity
AVF2S5_02490	COG1609	Transcriptional regulator
AVF2S5_02500	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AVF2S5_02510	COG0693	protein deglycase activity
AVF2S5_02525	COG0038	chloride channel
AVF2S5_02530	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AVF2S5_02555	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
AVF2S5_02565	COG1012	belongs to the aldehyde dehydrogenase family
AVF2S5_02570	COG0625	glutathione transferase activity
AVF2S5_02575	COG3119	arylsulfatase activity
AVF2S5_02580	COG1309	transcriptional regulator
AVF2S5_02585	COG4943	cyclic-guanylate-specific phosphodiesterase activity
AVF2S5_02595	COG0840	transmembrane signaling receptor activity
AVF2S5_02600	COG3914	O-linked N-acetylglucosamine transferase SPINDLY family
AVF2S5_02620	COG1349	DNA-binding transcription factor activity
AVF2S5_02665	COG0477	Major facilitator Superfamily
AVF2S5_02675	COG0778	Nitroreductase
AVF2S5_02700	COG1376	ErfK ybiS ycfS ynhG family protein
AVF2S5_02700	COG1388	LysM domain
AVF2S5_02705	COG1376	ErfK ybiS ycfS ynhG family protein
AVF2S5_02710	COG1846	Transcriptional regulator
AVF2S5_02715	COG1764	response to oxidative stress
AVF2S5_02740	COG3265	gluconokinase activity
AVF2S5_02750	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
AVF2S5_02755	COG0840	transmembrane signaling receptor activity
AVF2S5_02760	COG0840	transmembrane signaling receptor activity
AVF2S5_02770	COG0433	COG0433 Predicted ATPase
AVF2S5_02775	COG1473	amidohydrolase
AVF2S5_02780	COG0840	transmembrane signaling receptor activity
AVF2S5_02785	COG1968	undecaprenyl-diphosphatase activity
AVF2S5_02795	COG4214	carbohydrate transport
AVF2S5_02805	COG4213	ABC transporter substrate-binding protein
AVF2S5_02810	COG1846	Transcriptional regulator
AVF2S5_02810	COG1940	carbohydrate kinase activity
AVF2S5_02830	COG1120	ATPase activity
AVF2S5_02835	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AVF2S5_02850	COG2226	methyltransferase
AVF2S5_02870	COG2010	Cytochrome c
AVF2S5_02890	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AVF2S5_02895	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
AVF2S5_02900	COG1733	regulation of RNA biosynthetic process
AVF2S5_02905	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
AVF2S5_02915	COG3447	MASE1 domain protein
AVF2S5_02915	COG5001	Diguanylate cyclase
AVF2S5_02915	COG5002	protein histidine kinase activity
AVF2S5_02920	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AVF2S5_02965	COG2514	catechol 2,3-dioxygenase activity
AVF2S5_02980	COG3788	relative of glutathione S-transferase, MAPEG superfamily
AVF2S5_02985	COG1272	protein, Hemolysin III
AVF2S5_02990	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AVF2S5_03010	COG4957	zinc ion binding
AVF2S5_03015	COG1320	monovalent cation:proton antiporter activity
AVF2S5_03020	COG2212	antiporter activity
AVF2S5_03025	COG1863	multisubunit Na H antiporter MnhE subunit
AVF2S5_03030	COG0651	ATP synthesis coupled electron transport
AVF2S5_03035	COG1006	Multisubunit Na H antiporter MnhC subunit
AVF2S5_03040	COG2111	Na H antiporter
AVF2S5_03045	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AVF2S5_03045	COG2111	Na H antiporter
AVF2S5_03050	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AVF2S5_03070	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AVF2S5_03075	COG0577	efflux transmembrane transporter activity
AVF2S5_03075	COG1136	(ABC) transporter
AVF2S5_03095	COG2166	iron-sulfur cluster assembly
AVF2S5_03105	COG2205	protein histidine kinase activity
AVF2S5_03120	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AVF2S5_03185	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
AVF2S5_03190	COG2983	Belongs to the UPF0260 family
AVF2S5_03205	COG0789	Transcriptional regulator
AVF2S5_03235	COG4695	Portal protein
AVF2S5_03345	COG4520	surface antigen
AVF2S5_03350	COG4235	cytochrome complex assembly
AVF2S5_03355	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
AVF2S5_03360	COG1138	Cytochrome C-type biogenesis protein
AVF2S5_03365	COG3088	subunit of a heme lyase
AVF2S5_03375	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AVF2S5_03380	COG0745	RESPONSE REGULATOR receiver
AVF2S5_03385	COG2205	protein histidine kinase activity
AVF2S5_03390	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
AVF2S5_03395	COG2205	protein histidine kinase activity
AVF2S5_03395	COG2202	Pas domain
AVF2S5_03400	COG0308	aminopeptidase N
AVF2S5_03405	COG3290	protein histidine kinase activity
AVF2S5_03405	COG0840	transmembrane signaling receptor activity
AVF2S5_03440	COG0443	Heat shock 70 kDa protein
AVF2S5_03455	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AVF2S5_03470	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AVF2S5_03475	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AVF2S5_03485	COG2239	Acts as a magnesium transporter
AVF2S5_03490	COG2814	Major facilitator Superfamily
AVF2S5_03505	COG4172	Belongs to the ABC transporter superfamily
AVF2S5_03510	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AVF2S5_03515	COG0601	transmembrane transport
AVF2S5_03520	COG4166	transmembrane transport
AVF2S5_03525	COG0174	glutamine synthetase
AVF2S5_03540	COG1695	Transcriptional regulator
AVF2S5_03545	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
AVF2S5_03550	COG0463	Glycosyl transferase, family 2
AVF2S5_03560	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AVF2S5_03570	COG0625	glutathione transferase activity
AVF2S5_03585	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AVF2S5_03630	COG0741	lytic transglycosylase activity
AVF2S5_03635	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AVF2S5_03640	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
AVF2S5_03650	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AVF2S5_03650	COG2169	Transcriptional regulator
AVF2S5_03655	COG0840	transmembrane signaling receptor activity
AVF2S5_03665	COG1758	RNA polymerase activity
AVF2S5_03680	COG0681	Belongs to the peptidase S26 family
AVF2S5_03685	COG0571	ribonuclease III activity
AVF2S5_03690	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AVF2S5_03695	COG3180	Ammonia monooxygenase
AVF2S5_03700	COG1381	Involved in DNA repair and RecF pathway recombination
AVF2S5_03715	COG1418	mRNA catabolic process
AVF2S5_03730	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
AVF2S5_03755	COG1051	belongs to the nudix hydrolase family
AVF2S5_03770	COG1183	phosphatidylcholine synthase activity
AVF2S5_03775	COG0688	phosphatidylethanolamine metabolic process
AVF2S5_03780	COG5265	(ABC) transporter
AVF2S5_03785	COG2823	Periplasmic or secreted lipoprotein
AVF2S5_03785	COG1652	LysM domain
AVF2S5_03800	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AVF2S5_03840	COG0215	cysteine-tRNA ligase activity
AVF2S5_03845	COG5434	Belongs to the glycosyl hydrolase 28 family
AVF2S5_03850	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
AVF2S5_03855	COG1088	dTDP-glucose 4,6-dehydratase activity
AVF2S5_03860	COG1091	dTDP-4-dehydrorhamnose reductase activity
AVF2S5_03865	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
AVF2S5_03880	COG4221	oxidoreductase activity
AVF2S5_03885	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
AVF2S5_03890	COG1286	toxin biosynthetic process
AVF2S5_03895	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
AVF2S5_03900	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AVF2S5_03915	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AVF2S5_03920	COG0765	amino acid transport
AVF2S5_03925	COG0765	amino acid transport
AVF2S5_03935	COG0305	Participates in initiation and elongation during chromosome replication
AVF2S5_03940	COG0359	binds to the 23S rRNA
AVF2S5_03950	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
AVF2S5_03955	COG0360	Binds together with S18 to 16S ribosomal RNA
AVF2S5_03975	COG0667	Aldo Keto reductase
AVF2S5_03980	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
AVF2S5_03990	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AVF2S5_03995	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AVF2S5_04000	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
AVF2S5_04005	COG1561	YicC-like family, N-terminal region
AVF2S5_04010	COG0194	GDP metabolic process
AVF2S5_04015	COG0500	methyltransferase
AVF2S5_04020	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AVF2S5_04025	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
AVF2S5_04035	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
AVF2S5_04050	COG0671	phosphoesterase, PA-phosphatase related
AVF2S5_04055	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AVF2S5_04070	COG1505	serine-type exopeptidase activity
AVF2S5_04075	COG0488	(ABC) transporter
AVF2S5_04090	COG0105	UTP biosynthetic process
AVF2S5_04095	COG0314	molybdopterin synthase activity
AVF2S5_04105	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AVF2S5_04110	COG0322	excinuclease ABC activity
AVF2S5_04115	COG1028	Short-chain dehydrogenase reductase Sdr
AVF2S5_04125	COG0625	glutathione transferase activity
AVF2S5_04130	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
AVF2S5_04135	COG0243	molybdopterin cofactor binding
AVF2S5_04145	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AVF2S5_04145	COG3453	Protein conserved in bacteria
AVF2S5_04150	COG0640	Transcriptional regulator
AVF2S5_04160	COG2391	methyltransferase activity
AVF2S5_04165	COG0730	response to heat
AVF2S5_04170	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
AVF2S5_04175	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
AVF2S5_04180	COG0628	permease
AVF2S5_04190	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
AVF2S5_04195	COG0248	Ppx GppA phosphatase
AVF2S5_04200	COG1321	iron dependent repressor
AVF2S5_04205	COG1914	H( )-stimulated, divalent metal cation uptake system
AVF2S5_04225	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
AVF2S5_04240	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
AVF2S5_04255	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AVF2S5_04260	COG3300	MHYT domain
AVF2S5_04260	COG5001	Diguanylate cyclase
AVF2S5_04270	COG2199	diguanylate cyclase activity
AVF2S5_04270	COG2203	Gaf domain
AVF2S5_04270	COG2200	EAL domain
AVF2S5_04275	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
AVF2S5_04285	COG0113	porphobilinogen synthase activity
AVF2S5_04305	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AVF2S5_04310	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AVF2S5_04315	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AVF2S5_04315	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AVF2S5_04330	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
AVF2S5_04335	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AVF2S5_04340	COG2814	Major facilitator Superfamily
AVF2S5_04345	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
AVF2S5_04365	COG0416	fatty acid biosynthetic process
AVF2S5_04370	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AVF2S5_04375	COG0776	regulation of translation
AVF2S5_04400	COG0582	viral genome integration into host DNA
AVF2S5_04430	COG3436	PFAM IS66 Orf2 family protein
AVF2S5_04515	COG2963	transposase activity
AVF2S5_04525	COG4372	Transposase
AVF2S5_04535	COG3209	COG3209 Rhs family protein
AVF2S5_04550	COG3209	COG3209 Rhs family protein
AVF2S5_04590	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
AVF2S5_04630	COG1484	DNA-dependent DNA replication
AVF2S5_04635	COG4584	PFAM Integrase catalytic
AVF2S5_04705	COG1612	heme a metabolic process
AVF2S5_04710	COG3384	dioxygenase
AVF2S5_04720	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
AVF2S5_04725	COG0010	Belongs to the arginase family
AVF2S5_04740	COG2329	Antibiotic biosynthesis monooxygenase
AVF2S5_04745	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AVF2S5_04750	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
AVF2S5_04755	COG1832	CoA-binding protein
AVF2S5_04765	COG1832	CoA-binding protein
AVF2S5_04775	COG1408	metallophosphoesterase
AVF2S5_04785	COG2124	cytochrome p450
AVF2S5_04795	COG0740	serine-type endopeptidase activity
AVF2S5_04800	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
AVF2S5_04805	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
AVF2S5_04835	COG1024	Enoyl-CoA hydratase
AVF2S5_04855	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AVF2S5_04860	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AVF2S5_04865	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AVF2S5_04870	COG0649	NAD binding
AVF2S5_04880	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
AVF2S5_04885	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
AVF2S5_04890	COG0052	Belongs to the universal ribosomal protein uS2 family
AVF2S5_04900	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
AVF2S5_04905	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AVF2S5_04915	COG0713	ATP synthesis coupled electron transport
AVF2S5_04930	COG1007	ATP synthesis coupled electron transport
AVF2S5_04945	COG0346	lactoylglutathione lyase activity
AVF2S5_04960	COG0442	prolyl-tRNA aminoacylation
AVF2S5_04970	COG1136	(ABC) transporter
AVF2S5_04985	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AVF2S5_05000	COG0784	Response regulator, receiver
AVF2S5_05010	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AVF2S5_05015	COG0477	Major facilitator Superfamily
AVF2S5_05025	COG0557	exoribonuclease II activity
AVF2S5_05030	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AVF2S5_05040	COG0758	DNA mediated transformation
AVF2S5_05045	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
AVF2S5_05055	COG0540	Belongs to the ATCase OTCase family
AVF2S5_05060	COG1960	acyl-CoA dehydrogenase activity
AVF2S5_05090	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
AVF2S5_05095	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
AVF2S5_05100	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AVF2S5_05105	COG0154	amidase activity
AVF2S5_05120	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
AVF2S5_05125	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AVF2S5_05125	COG3952	Lipid A Biosynthesis
AVF2S5_05135	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AVF2S5_05155	COG4765	Protein conserved in bacteria
AVF2S5_05160	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
AVF2S5_05170	COG0511	ligase activity, forming carbon-carbon bonds
AVF2S5_05175	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
AVF2S5_05180	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AVF2S5_05185	COG0436	Aminotransferase
AVF2S5_05195	COG1530	ribonuclease E activity
AVF2S5_05200	COG0860	N-Acetylmuramoyl-L-alanine amidase
AVF2S5_05205	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
AVF2S5_05215	COG0284	orotidine-5'-phosphate decarboxylase activity
AVF2S5_05225	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AVF2S5_05250	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AVF2S5_05265	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AVF2S5_05290	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AVF2S5_05300	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
AVF2S5_05305	COG0081	regulation of translation
AVF2S5_05310	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
AVF2S5_05315	COG0222	ribosome binding
AVF2S5_05320	COG0085	RNA polymerase activity
AVF2S5_05325	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AVF2S5_05340	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
AVF2S5_05345	COG0049	tRNA binding
AVF2S5_05350	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AVF2S5_05355	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AVF2S5_05360	COG0051	transcription antitermination factor activity, RNA binding
AVF2S5_05365	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
AVF2S5_05370	COG0088	Forms part of the polypeptide exit tunnel
AVF2S5_05375	COG0089	rRNA binding
AVF2S5_05380	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
AVF2S5_05385	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AVF2S5_05390	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
AVF2S5_05395	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
AVF2S5_05400	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
AVF2S5_05405	COG0255	Belongs to the universal ribosomal protein uL29 family
AVF2S5_05410	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
AVF2S5_05415	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
AVF2S5_05420	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
AVF2S5_05425	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
AVF2S5_05430	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
AVF2S5_05435	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
AVF2S5_05440	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
AVF2S5_05445	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
AVF2S5_05450	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
AVF2S5_05455	COG1841	ribosomal large subunit assembly
AVF2S5_05460	COG0200	Binds to the 23S rRNA
AVF2S5_05465	COG0201	protein transport
AVF2S5_05470	COG0563	adenylate kinase activity
AVF2S5_05475	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
AVF2S5_05480	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
AVF2S5_05485	COG0202	RNA polymerase activity
AVF2S5_05490	COG0203	ribosomal protein L17
AVF2S5_05505	COG2897	thiosulfate sulfurtransferase activity
AVF2S5_05515	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AVF2S5_05520	COG0415	Belongs to the DNA photolyase family
AVF2S5_05530	COG0739	heme binding
AVF2S5_05535	COG2833	Protein of unknown function (DUF455)
AVF2S5_05545	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AVF2S5_05570	COG0280	phosphate acetyltransferase
AVF2S5_05570	COG0281	malic enzyme
AVF2S5_05580	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AVF2S5_05585	COG1127	ABC transporter
AVF2S5_05595	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
AVF2S5_05595	COG3218	ABC-type transport auxiliary lipoprotein component
AVF2S5_05600	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AVF2S5_05620	COG0047	phosphoribosylformylglycinamidine synthase activity
AVF2S5_05625	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AVF2S5_05630	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
AVF2S5_05645	COG3706	GGDEF domain
AVF2S5_05655	COG0538	isocitrate dehydrogenase activity
AVF2S5_05660	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
AVF2S5_05665	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
AVF2S5_05675	COG1253	flavin adenine dinucleotide binding
AVF2S5_05685	COG0657	acetylesterase activity
AVF2S5_05685	COG2755	lipolytic protein G-D-S-L family
AVF2S5_05690	COG2195	Cleaves the N-terminal amino acid of tripeptides
AVF2S5_05705	COG0861	Integral membrane protein TerC family
AVF2S5_05710	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
AVF2S5_05715	COG2066	Belongs to the glutaminase family
AVF2S5_05725	COG0037	tRNA processing
AVF2S5_05730	COG0483	inositol monophosphate 1-phosphatase activity
AVF2S5_05735	COG0483	inositol monophosphate 1-phosphatase activity
AVF2S5_05740	COG2814	Major facilitator Superfamily
AVF2S5_05745	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
AVF2S5_05760	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AVF2S5_05765	COG0484	heat shock protein binding
AVF2S5_05775	COG0321	lipoyl(octanoyl) transferase activity
AVF2S5_05920	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
AVF2S5_06030	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
AVF2S5_06030	COG0463	Glycosyl transferase, family 2
AVF2S5_06045	COG4372	Transposase
AVF2S5_06055	COG2963	transposase activity
AVF2S5_06075	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
AVF2S5_06080	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
AVF2S5_06110	COG0242	peptide deformylase activity
AVF2S5_06120	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AVF2S5_06125	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AVF2S5_06130	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AVF2S5_06135	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AVF2S5_06140	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AVF2S5_06165	COG0823	Involved in the tonB-independent uptake of proteins
AVF2S5_06170	COG0778	Nitroreductase
AVF2S5_06180	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AVF2S5_06185	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
AVF2S5_06205	COG2205	protein histidine kinase activity
AVF2S5_06205	COG2202	Pas domain
AVF2S5_06215	COG1573	uracil-dna glycosylase
AVF2S5_06220	COG1522	sequence-specific DNA binding
AVF2S5_06225	COG2084	Dehydrogenase
AVF2S5_06240	COG5425	PFAM Usg family protein
AVF2S5_06265	COG1763	Mo-molybdopterin cofactor biosynthetic process
AVF2S5_06270	COG0746	molybdenum cofactor guanylyltransferase activity
AVF2S5_06280	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AVF2S5_06290	COG3706	GGDEF domain
AVF2S5_06305	COG0114	fumarate hydratase activity
AVF2S5_06310	COG2989	Protein conserved in bacteria
AVF2S5_06315	COG0546	phosphoglycolate phosphatase activity
AVF2S5_06320	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
AVF2S5_06335	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
AVF2S5_06370	COG5001	Diguanylate cyclase
AVF2S5_06370	COG3706	GGDEF domain
AVF2S5_06370	COG4251	negative regulation of phosphorylation
AVF2S5_06370	COG2203	Gaf domain
AVF2S5_06375	COG0556	nucleotide-excision repair
AVF2S5_06395	COG3161	chorismate lyase activity
AVF2S5_06405	COG2877	3-deoxy-8-phosphooctulonate synthase activity
AVF2S5_06410	COG0148	phosphopyruvate hydratase activity
AVF2S5_06420	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
AVF2S5_06425	COG0022	dehydrogenase e1 component
AVF2S5_06425	COG0508	dehydrogenase complex catalyzes the overall conversion of
AVF2S5_06430	COG0508	dehydrogenase complex catalyzes the overall conversion of
AVF2S5_06445	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AVF2S5_06455	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AVF2S5_06475	COG0477	Major facilitator Superfamily
AVF2S5_06480	COG2867	negative regulation of translational initiation
AVF2S5_06485	COG1058	Belongs to the CinA family
AVF2S5_06485	COG1546	Belongs to the CinA family
AVF2S5_06490	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
AVF2S5_06490	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
AVF2S5_06500	COG3852	Histidine kinase
AVF2S5_06505	COG2204	response regulator
AVF2S5_06510	COG5000	phosphorelay sensor kinase activity
AVF2S5_06515	COG2204	response regulator
AVF2S5_06520	COG1923	regulation of RNA biosynthetic process
AVF2S5_06525	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AVF2S5_06535	COG3956	TIGRFAM MazG family protein
AVF2S5_06545	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AVF2S5_06545	COG1648	precorrin-2 dehydrogenase activity
AVF2S5_06570	COG1028	Short-chain dehydrogenase reductase Sdr
AVF2S5_06580	COG1686	Belongs to the peptidase S11 family
AVF2S5_06585	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AVF2S5_06595	COG0730	response to heat
AVF2S5_06600	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AVF2S5_06605	COG0084	hydrolase, TatD family'
AVF2S5_06610	COG0321	lipoyl(octanoyl) transferase activity
AVF2S5_06610	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
AVF2S5_06625	COG0785	Cytochrome C biogenesis protein
AVF2S5_06630	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AVF2S5_06635	COG1183	phosphatidylcholine synthase activity
AVF2S5_06640	COG3845	ABC transporter
AVF2S5_06645	COG4603	Belongs to the binding-protein-dependent transport system permease family
AVF2S5_06650	COG1079	Belongs to the binding-protein-dependent transport system permease family
AVF2S5_06660	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AVF2S5_06665	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AVF2S5_06705	COG0523	cobalamin synthesis protein
AVF2S5_06715	COG1121	(ABC) transporter
AVF2S5_06720	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AVF2S5_06725	COG0735	belongs to the Fur family
AVF2S5_06745	COG1686	Belongs to the peptidase S11 family
AVF2S5_06780	COG1752	Esterase of the alpha-beta hydrolase superfamily
AVF2S5_06785	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
AVF2S5_06790	COG0302	gtp cyclohydrolase
AVF2S5_06800	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
AVF2S5_06810	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AVF2S5_06825	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
AVF2S5_06830	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
AVF2S5_06875	COG0187	DNA topoisomerase II activity
AVF2S5_06890	COG0149	triose-phosphate isomerase activity
AVF2S5_06900	COG0504	CTP synthase activity
AVF2S5_06925	COG0633	Ferredoxin
AVF2S5_06935	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AVF2S5_06970	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AVF2S5_06970	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AVF2S5_06975	COG0509	glycine decarboxylation via glycine cleavage system
AVF2S5_06980	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AVF2S5_07000	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AVF2S5_07005	COG0564	pseudouridine synthase activity
AVF2S5_07010	COG0546	phosphoglycolate phosphatase activity
AVF2S5_07025	COG0477	Major facilitator Superfamily
AVF2S5_07040	COG2003	Belongs to the UPF0758 family
AVF2S5_07045	COG0024	Methionine aminopeptidase
AVF2S5_07055	COG2855	membrane
AVF2S5_07060	COG1489	DNA binding
AVF2S5_07065	COG3243	poly(R)-hydroxyalkanoic acid synthase
AVF2S5_07075	COG0436	Aminotransferase
AVF2S5_07085	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
AVF2S5_07110	COG0346	lactoylglutathione lyase activity
AVF2S5_07115	COG1278	Cold shock
AVF2S5_07145	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AVF2S5_07155	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
AVF2S5_07165	COG0697	spore germination
AVF2S5_07190	COG0174	glutamine synthetase
AVF2S5_07195	COG0347	Belongs to the P(II) protein family
AVF2S5_07200	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
AVF2S5_07200	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
AVF2S5_07215	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AVF2S5_07220	COG0629	single-stranded DNA binding
AVF2S5_07230	COG2095	MarC family integral membrane protein
AVF2S5_07235	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AVF2S5_07265	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
AVF2S5_07280	COG1653	transport
AVF2S5_07285	COG1175	transmembrane transport
AVF2S5_07290	COG0395	ABC-type sugar transport system, permease component
AVF2S5_07295	COG3842	ATPase activity
AVF2S5_07315	COG0667	Aldo Keto reductase
AVF2S5_07320	COG3507	Belongs to the glycosyl hydrolase 43 family
AVF2S5_07335	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
AVF2S5_07340	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
AVF2S5_07345	COG0129	dihydroxy-acid dehydratase activity
AVF2S5_07365	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AVF2S5_07390	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AVF2S5_07415	COG0513	Belongs to the DEAD box helicase family
AVF2S5_07420	COG1280	lysine exporter protein (LysE YggA)
AVF2S5_07425	COG2945	thiolester hydrolase activity
AVF2S5_07430	COG1104	cysteine desulfurase activity
AVF2S5_07435	COG0719	Fe-S assembly protein
AVF2S5_07445	COG0396	ATPase activity
AVF2S5_07450	COG0719	Fe-S assembly protein
AVF2S5_07460	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AVF2S5_07465	COG2151	metal-sulfur cluster biosynthetic enzyme
AVF2S5_07480	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
AVF2S5_07495	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
AVF2S5_07500	COG0343	queuine tRNA-ribosyltransferase activity
AVF2S5_07510	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
AVF2S5_07520	COG2826	transposase and inactivated derivatives, IS30 family
AVF2S5_07525	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
AVF2S5_07530	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AVF2S5_07535	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
AVF2S5_07540	COG2080	2 iron, 2 sulfur cluster binding
AVF2S5_07570	COG2062	phosphohistidine phosphatase, SixA
AVF2S5_07575	COG3106	COG3106 Predicted ATPase
AVF2S5_07580	COG3768	UPF0283 membrane protein
AVF2S5_07595	COG0436	Aminotransferase
AVF2S5_07605	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
AVF2S5_07610	COG0544	peptidyl-prolyl cis-trans isomerase activity
AVF2S5_07640	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
AVF2S5_07645	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AVF2S5_07665	COG0252	asparaginase activity
AVF2S5_07675	COG0737	Belongs to the 5'-nucleotidase family
AVF2S5_07685	COG0463	Glycosyl transferase, family 2
AVF2S5_07690	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AVF2S5_07705	COG1116	anion transmembrane transporter activity
AVF2S5_07710	COG3665	Urea carboxylase-associated protein
AVF2S5_07720	COG4770	biotin carboxylase activity
AVF2S5_07740	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
AVF2S5_07745	COG2153	protein acetylation
AVF2S5_07750	COG1671	Belongs to the UPF0178 family
AVF2S5_07760	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
AVF2S5_07765	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AVF2S5_07775	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AVF2S5_07780	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AVF2S5_07785	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AVF2S5_07790	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AVF2S5_07795	COG0750	zinc metalloprotease
AVF2S5_07805	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AVF2S5_07810	COG0233	cytoplasmic translational termination
AVF2S5_07815	COG0528	UMP kinase activity
AVF2S5_07820	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
AVF2S5_07825	COG0052	Belongs to the universal ribosomal protein uS2 family
AVF2S5_07850	COG0537	adenosine 5'-monophosphoramidase activity
AVF2S5_07870	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
AVF2S5_07895	COG2267	carboxylic ester hydrolase activity
AVF2S5_07915	COG0626	cystathionine gamma-synthase activity
AVF2S5_07920	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AVF2S5_07925	COG4597	amino acid ABC transporter
AVF2S5_07930	COG0765	amino acid transport
AVF2S5_07935	COG1126	abc transporter atp-binding protein
AVF2S5_07945	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AVF2S5_07950	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
AVF2S5_07960	COG2313	pseudouridylate synthase activity
AVF2S5_07965	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AVF2S5_07970	COG0658	competence protein
AVF2S5_07970	COG2333	competence protein COMEC
AVF2S5_07975	COG0372	Belongs to the citrate synthase family
AVF2S5_07985	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AVF2S5_07990	COG0134	indole-3-glycerol-phosphate synthase activity
AVF2S5_07995	COG0315	cyclic pyranopterin monophosphate synthase activity
AVF2S5_08000	COG0303	'Molybdopterin
AVF2S5_08005	COG0671	phosphoesterase, PA-phosphatase related
AVF2S5_08010	COG1492	cobalamin metabolic process
AVF2S5_08020	COG4176	ABC-type proline glycine betaine transport system permease component
AVF2S5_08025	COG0517	IMP dehydrogenase activity
AVF2S5_08025	COG4175	Glycine betaine
AVF2S5_08045	COG3698	Phosphodiester glycosidase
AVF2S5_08070	COG0583	DNA-binding transcription factor activity
AVF2S5_08100	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AVF2S5_08120	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AVF2S5_08130	COG0840	transmembrane signaling receptor activity
AVF2S5_08140	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
AVF2S5_08150	COG1546	Belongs to the CinA family
AVF2S5_08150	COG1058	Belongs to the CinA family
AVF2S5_08155	COG0840	transmembrane signaling receptor activity
AVF2S5_08155	COG2972	Histidine kinase
AVF2S5_08165	COG0835	chemotaxis
AVF2S5_08175	COG1760	l-serine dehydratase
AVF2S5_08200	COG2239	Acts as a magnesium transporter
AVF2S5_08225	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
AVF2S5_08230	COG2099	Precorrin-6x reductase
AVF2S5_08235	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
AVF2S5_08245	COG2875	Belongs to the precorrin methyltransferase family
AVF2S5_08325	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
AVF2S5_08350	COG1862	Preprotein translocase
AVF2S5_08365	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
AVF2S5_08370	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
AVF2S5_08375	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
AVF2S5_08380	COG0805	protein transport
AVF2S5_08390	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AVF2S5_08395	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
AVF2S5_08400	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
AVF2S5_08405	COG1472	Belongs to the glycosyl hydrolase 3 family
AVF2S5_08415	COG0018	arginyl-trna synthetase
AVF2S5_08420	COG0232	Belongs to the dGTPase family. Type 2 subfamily
AVF2S5_08425	COG0316	Belongs to the HesB IscA family
AVF2S5_08445	COG0525	valine-tRNA ligase activity
AVF2S5_08460	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
AVF2S5_08500	COG4608	Belongs to the ABC transporter superfamily
AVF2S5_08560	COG0842	Transport permease protein
AVF2S5_08565	COG1131	(ABC) transporter
AVF2S5_08575	COG0745	RESPONSE REGULATOR receiver
AVF2S5_08590	COG2226	methyltransferase
AVF2S5_08595	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
AVF2S5_08595	COG3264	Mechanosensitive ion channel
AVF2S5_08615	COG4558	Periplasmic binding protein
AVF2S5_08620	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AVF2S5_08625	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
AVF2S5_08665	COG2963	transposase activity
AVF2S5_08755	COG1082	Xylose isomerase domain protein TIM barrel
AVF2S5_08760	COG0438	transferase activity, transferring glycosyl groups
AVF2S5_08765	COG1028	Short-chain dehydrogenase reductase Sdr
AVF2S5_08770	COG1063	alcohol dehydrogenase
AVF2S5_08775	COG1940	carbohydrate kinase activity
AVF2S5_08790	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AVF2S5_08800	COG3328	transposase activity
AVF2S5_08845	COG0384	phenazine biosynthesis protein PhzF
AVF2S5_08860	COG0789	Transcriptional regulator
AVF2S5_08865	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
AVF2S5_08875	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AVF2S5_08890	COG1522	sequence-specific DNA binding
AVF2S5_08895	COG1794	racemase activity, acting on amino acids and derivatives
AVF2S5_08900	COG1309	transcriptional regulator
AVF2S5_08905	COG2814	Major facilitator Superfamily
AVF2S5_08915	COG1733	regulation of RNA biosynthetic process
AVF2S5_08925	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
AVF2S5_08930	COG0789	Transcriptional regulator
AVF2S5_08935	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AVF2S5_08945	COG0656	L-ascorbic acid biosynthetic process
AVF2S5_08960	COG0028	Belongs to the TPP enzyme family
AVF2S5_08980	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
AVF2S5_08985	COG0560	Phosphoserine phosphatase
AVF2S5_08985	COG3830	Belongs to the UPF0237 family
AVF2S5_09000	COG0330	HflC and HflK could
AVF2S5_09015	COG2259	Doxx family
AVF2S5_09020	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
AVF2S5_09055	COG0277	FAD linked oxidase domain protein
AVF2S5_09060	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AVF2S5_09065	COG0581	inorganic phosphate transmembrane transporter activity
AVF2S5_09070	COG0573	inorganic phosphate transmembrane transporter activity
AVF2S5_09075	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AVF2S5_09095	COG4993	Dehydrogenase
AVF2S5_09100	COG1335	isochorismatase
AVF2S5_09105	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
AVF2S5_09110	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
AVF2S5_09120	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
AVF2S5_09155	COG2264	protein methyltransferase activity
AVF2S5_09160	COG1999	signal sequence binding
AVF2S5_09165	COG0840	transmembrane signaling receptor activity
AVF2S5_09170	COG0835	chemotaxis
AVF2S5_09185	COG2176	DNA-directed DNA polymerase activity
AVF2S5_09195	COG0840	transmembrane signaling receptor activity
AVF2S5_09200	COG0456	acetyltransferase
AVF2S5_09235	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AVF2S5_09245	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AVF2S5_09255	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AVF2S5_09265	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AVF2S5_09270	COG0849	cell division
AVF2S5_09275	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
AVF2S5_09280	COG1181	Belongs to the D-alanine--D-alanine ligase family
AVF2S5_09285	COG0477	Major facilitator Superfamily
AVF2S5_09290	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AVF2S5_09295	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AVF2S5_09300	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AVF2S5_09310	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
AVF2S5_09315	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AVF2S5_09325	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AVF2S5_09340	COG0275	rRNA processing
AVF2S5_09345	COG2001	Belongs to the MraZ family
AVF2S5_09365	COG3023	N-Acetylmuramoyl-L-alanine amidase
AVF2S5_09430	COG2226	methyltransferase
AVF2S5_09440	COG0840	transmembrane signaling receptor activity
AVF2S5_09445	COG2972	Histidine kinase
AVF2S5_09445	COG0840	transmembrane signaling receptor activity
AVF2S5_09460	COG2267	carboxylic ester hydrolase activity
AVF2S5_09465	COG0697	spore germination
AVF2S5_09470	COG0028	Belongs to the TPP enzyme family
AVF2S5_09480	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AVF2S5_09485	COG0251	oxidation-reduction process
AVF2S5_09500	COG1376	ErfK ybiS ycfS ynhG family protein
AVF2S5_09525	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
AVF2S5_09530	COG4149	molybdate abc transporter
AVF2S5_09535	COG3842	ATPase activity
AVF2S5_09550	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AVF2S5_09555	COG2197	response regulator
AVF2S5_09560	COG1396	sequence-specific DNA binding
AVF2S5_09625	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AVF2S5_09630	COG0697	spore germination
AVF2S5_09640	COG2968	Membrane
AVF2S5_09650	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AVF2S5_09720	COG1278	Cold shock
AVF2S5_09755	COG0432	Pfam Uncharacterised protein family UPF0047
AVF2S5_09760	COG2203	Gaf domain
AVF2S5_09760	COG3706	GGDEF domain
AVF2S5_09760	COG4251	negative regulation of phosphorylation
AVF2S5_09760	COG5001	Diguanylate cyclase
AVF2S5_09770	COG0583	DNA-binding transcription factor activity
AVF2S5_09785	COG1473	amidohydrolase
AVF2S5_09805	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AVF2S5_09830	COG0505	Belongs to the CarA family
AVF2S5_09835	COG0534	Mate efflux family protein
AVF2S5_09840	COG0583	DNA-binding transcription factor activity
AVF2S5_09845	COG0667	Aldo Keto reductase
AVF2S5_09850	COG2321	neutral zinc metallopeptidase
AVF2S5_09865	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AVF2S5_09875	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AVF2S5_09910	COG1522	sequence-specific DNA binding
AVF2S5_09915	COG0492	ferredoxin-NADP+ reductase activity
AVF2S5_09920	COG0583	DNA-binding transcription factor activity
AVF2S5_09925	COG0640	Transcriptional regulator
AVF2S5_09930	COG1902	pentaerythritol trinitrate reductase activity
AVF2S5_09950	COG0387	Pfam Sodium calcium exchanger
AVF2S5_09960	COG0436	Aminotransferase
AVF2S5_09975	COG1278	Cold shock
AVF2S5_09980	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AVF2S5_09990	COG1846	Transcriptional regulator
AVF2S5_09995	COG0745	RESPONSE REGULATOR receiver
AVF2S5_10000	COG2205	protein histidine kinase activity
AVF2S5_10005	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AVF2S5_10025	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
AVF2S5_10040	COG0006	proline dipeptidase activity
AVF2S5_10060	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AVF2S5_10075	COG1012	belongs to the aldehyde dehydrogenase family
AVF2S5_10085	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
AVF2S5_10100	COG0193	aminoacyl-tRNA hydrolase activity
AVF2S5_10110	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
AVF2S5_10115	COG0012	GTP binding
AVF2S5_10135	COG0386	Belongs to the glutathione peroxidase family
AVF2S5_10150	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AVF2S5_10155	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
AVF2S5_10155	COG2857	Cytochrome c1
AVF2S5_10180	COG1132	(ABC) transporter
AVF2S5_10185	COG1132	(ABC) transporter
AVF2S5_10190	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
AVF2S5_10200	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AVF2S5_10210	COG0408	coproporphyrinogen oxidase activity
AVF2S5_10225	COG0617	tRNA 3'-terminal CCA addition
AVF2S5_10240	COG0714	Associated with various cellular activities
AVF2S5_10265	COG0454	-acetyltransferase
AVF2S5_10285	COG0435	Glutathione S-transferase
AVF2S5_10290	COG0494	nUDIX hydrolase
AVF2S5_10300	COG0740	serine-type endopeptidase activity
AVF2S5_10305	COG3135	benzoate transporter
AVF2S5_10310	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AVF2S5_10320	COG4115	mRNA cleavage
AVF2S5_10375	COG0512	Glutamine amidotransferase of anthranilate synthase
AVF2S5_10375	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AVF2S5_10385	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
AVF2S5_10390	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
AVF2S5_10410	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
AVF2S5_10425	COG2759	Belongs to the formate--tetrahydrofolate ligase family
AVF2S5_10435	COG2197	response regulator
AVF2S5_10450	COG1435	thymidine kinase activity
AVF2S5_10465	COG4175	Glycine betaine
AVF2S5_10480	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AVF2S5_10515	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
AVF2S5_10525	COG4115	mRNA cleavage
AVF2S5_10530	COG0366	Alpha amylase catalytic
AVF2S5_10540	COG1160	GTP binding
AVF2S5_10560	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
AVF2S5_10575	COG0024	Methionine aminopeptidase
AVF2S5_10580	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AVF2S5_10585	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AVF2S5_10590	COG1028	Short-chain dehydrogenase reductase Sdr
AVF2S5_10600	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AVF2S5_10610	COG0457	Tetratricopeptide repeat
AVF2S5_10615	COG0583	DNA-binding transcription factor activity
AVF2S5_10625	COG0402	S-adenosylhomocysteine deaminase activity
AVF2S5_10630	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AVF2S5_10640	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AVF2S5_10645	COG0137	argininosuccinate synthase activity
AVF2S5_10680	COG2351	hydroxyisourate hydrolase activity
AVF2S5_10685	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
AVF2S5_10690	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AVF2S5_10695	COG0174	glutamine synthetase
AVF2S5_10705	COG3195	allantoin biosynthetic process
AVF2S5_10705	COG3648	Uricase
AVF2S5_10710	COG1064	alcohol dehydrogenase
AVF2S5_10725	COG3706	GGDEF domain
AVF2S5_10740	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AVF2S5_10745	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AVF2S5_10745	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
AVF2S5_10760	COG0513	Belongs to the DEAD box helicase family
AVF2S5_10775	COG1733	regulation of RNA biosynthetic process
AVF2S5_10885	COG2308	Evidence 4 Homologs of previously reported genes of
AVF2S5_10900	COG2346	COG2346, Truncated hemoglobins
AVF2S5_10920	COG0493	'glutamate synthase
AVF2S5_10940	COG1309	transcriptional regulator
AVF2S5_10950	COG2852	Protein conserved in bacteria
AVF2S5_10970	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AVF2S5_10975	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AVF2S5_10980	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AVF2S5_11005	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
AVF2S5_11010	COG0830	nickel cation binding
AVF2S5_11015	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
AVF2S5_11020	COG5001	Diguanylate cyclase
AVF2S5_11020	COG5002	protein histidine kinase activity
AVF2S5_11040	COG0804	urea catabolic process
AVF2S5_11045	COG1442	glycosyl transferase family 8
AVF2S5_11050	COG3755	Protein conserved in bacteria
AVF2S5_11055	COG0832	Belongs to the urease beta subunit family
AVF2S5_11060	COG3813	Protein conserved in bacteria
AVF2S5_11065	COG0831	urea catabolic process
AVF2S5_11070	COG0829	nickel cation binding
AVF2S5_11115	COG4251	negative regulation of phosphorylation
AVF2S5_11125	COG2205	protein histidine kinase activity
AVF2S5_11125	COG0784	Response regulator, receiver
AVF2S5_11170	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
AVF2S5_11175	COG2894	cell division
AVF2S5_11180	COG0850	regulation of cytokinetic process
AVF2S5_11225	COG2814	Major facilitator Superfamily
AVF2S5_11235	COG1218	3'(2'),5'-bisphosphate nucleotidase
AVF2S5_11290	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AVF2S5_11300	COG0564	pseudouridine synthase activity
AVF2S5_11305	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
AVF2S5_11305	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AVF2S5_11310	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AVF2S5_11325	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
AVF2S5_11340	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AVF2S5_11350	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
AVF2S5_11370	COG1116	anion transmembrane transporter activity
AVF2S5_11380	COG0402	S-adenosylhomocysteine deaminase activity
AVF2S5_11415	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
AVF2S5_11450	COG1175	transmembrane transport
AVF2S5_11475	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AVF2S5_11485	COG0482	sulfurtransferase activity
AVF2S5_11495	COG4774	siderophore transport
AVF2S5_11515	COG1120	ATPase activity
AVF2S5_11525	COG4774	siderophore transport
AVF2S5_11555	COG1294	oxidase, subunit
AVF2S5_11560	COG1271	oxidase subunit
AVF2S5_11565	COG0840	transmembrane signaling receptor activity
AVF2S5_11570	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AVF2S5_11595	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AVF2S5_11600	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
AVF2S5_11605	COG0632	four-way junction helicase activity
AVF2S5_11610	COG2002	toxin-antitoxin pair type II binding
AVF2S5_11620	COG2255	four-way junction helicase activity
AVF2S5_11625	COG1408	metallophosphoesterase
AVF2S5_11630	COG0494	nUDIX hydrolase
AVF2S5_11645	COG0824	Thioesterase
AVF2S5_11665	COG0823	Involved in the tonB-independent uptake of proteins
AVF2S5_11670	COG2885	chlorophyll binding
AVF2S5_11680	COG0037	tRNA processing
AVF2S5_11685	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AVF2S5_11690	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AVF2S5_11695	COG0217	transcriptional regulatory protein
AVF2S5_11765	COG0840	transmembrane signaling receptor activity
AVF2S5_11770	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
AVF2S5_11775	COG1692	metallophosphoesterase
AVF2S5_11780	COG0126	phosphoglycerate kinase activity
AVF2S5_11785	COG3588	fructose-bisphosphate aldolase
AVF2S5_11790	COG0384	phenazine biosynthesis protein PhzF
AVF2S5_11820	COG0254	rRNA binding
AVF2S5_11825	COG1132	(ABC) transporter
AVF2S5_11850	COG0483	inositol monophosphate 1-phosphatase activity
AVF2S5_11860	COG0352	thiamine-phosphate diphosphorylase activity
AVF2S5_11870	COG0640	Transcriptional regulator
AVF2S5_11885	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
AVF2S5_11890	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
AVF2S5_11895	COG0257	Belongs to the bacterial ribosomal protein bL36 family
AVF2S5_11900	COG0457	Tetratricopeptide repeat
AVF2S5_11905	COG0596	Alpha beta hydrolase
AVF2S5_11910	COG0469	pyruvate kinase activity
AVF2S5_11930	COG3750	Belongs to the UPF0335 family
AVF2S5_11935	COG0583	DNA-binding transcription factor activity
AVF2S5_11940	COG0679	Auxin Efflux Carrier
AVF2S5_11960	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AVF2S5_11960	COG0512	Glutamine amidotransferase of anthranilate synthase
AVF2S5_11965	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AVF2S5_11975	COG5310	Homospermidine synthase
AVF2S5_11985	COG0737	Belongs to the 5'-nucleotidase family
AVF2S5_11990	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
AVF2S5_12000	COG0840	transmembrane signaling receptor activity
AVF2S5_12005	COG0602	queuosine metabolic process
AVF2S5_12010	COG0720	synthase
AVF2S5_12015	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
AVF2S5_12020	COG0330	HflC and HflK could
AVF2S5_12030	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
AVF2S5_12030	COG0517	IMP dehydrogenase activity
AVF2S5_12040	COG1210	Utp--glucose-1-phosphate uridylyltransferase
AVF2S5_12045	COG2951	lytic endotransglycosylase activity
AVF2S5_12055	COG0840	transmembrane signaling receptor activity
AVF2S5_12065	COG0067	glutamate synthase
AVF2S5_12065	COG0069	glutamate synthase activity
AVF2S5_12065	COG0070	glutamate synthase
AVF2S5_12075	COG0071	Belongs to the small heat shock protein (HSP20) family
AVF2S5_12110	COG0668	transmembrane transport
AVF2S5_12115	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
AVF2S5_12115	COG0662	Cupin 2, conserved barrel domain protein
AVF2S5_12125	COG2307	Protein conserved in bacteria
AVF2S5_12125	COG2308	Evidence 4 Homologs of previously reported genes of
AVF2S5_12145	COG0058	SHG alpha-glucan phosphorylase activity
AVF2S5_12150	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
AVF2S5_12155	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
AVF2S5_12160	COG0297	glycogen (starch) synthase activity
AVF2S5_12165	COG0033	Phosphoglucomutase
AVF2S5_12170	COG1523	belongs to the glycosyl hydrolase 13 family
AVF2S5_12205	COG0828	Belongs to the bacterial ribosomal protein bS21 family
AVF2S5_12210	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AVF2S5_12220	COG0446	pyridine nucleotide-disulphide oxidoreductase
AVF2S5_12220	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AVF2S5_12235	COG1733	regulation of RNA biosynthetic process
AVF2S5_12255	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
AVF2S5_12260	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
AVF2S5_12265	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AVF2S5_12270	COG1609	Transcriptional regulator
AVF2S5_12275	COG1846	Transcriptional regulator
AVF2S5_12285	COG0523	cobalamin synthesis protein
AVF2S5_12295	COG0840	transmembrane signaling receptor activity
AVF2S5_12300	COG3047	cAMP biosynthetic process
AVF2S5_12325	COG0583	DNA-binding transcription factor activity
AVF2S5_12355	COG0800	Aldolase
AVF2S5_12360	COG2954	triphosphatase activity
AVF2S5_12370	COG2378	regulation of single-species biofilm formation
AVF2S5_12380	COG1054	Belongs to the UPF0176 family
AVF2S5_12385	COG2202	Pas domain
AVF2S5_12385	COG2200	EAL domain
AVF2S5_12385	COG2199	diguanylate cyclase activity
AVF2S5_12405	COG0673	inositol 2-dehydrogenase activity
AVF2S5_12415	COG2115	Belongs to the xylose isomerase family
AVF2S5_12420	COG1070	Carbohydrate kinase
AVF2S5_12425	COG1609	Transcriptional regulator
AVF2S5_12440	COG1309	transcriptional regulator
AVF2S5_12445	COG1253	flavin adenine dinucleotide binding
AVF2S5_12465	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AVF2S5_12490	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AVF2S5_12510	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
AVF2S5_12515	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AVF2S5_12520	COG3273	potassium ion transport
AVF2S5_12520	COG0471	metal ion transport
AVF2S5_12535	COG2274	protein secretion by the type I secretion system
AVF2S5_12570	COG4172	Belongs to the ABC transporter superfamily
AVF2S5_12575	COG1473	amidohydrolase
AVF2S5_12590	COG0601	transmembrane transport
AVF2S5_12595	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AVF2S5_12600	COG0842	Transport permease protein
AVF2S5_12605	COG0842	Transport permease protein
AVF2S5_12605	COG1129	ABC transporter
AVF2S5_12610	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AVF2S5_12620	COG3454	Phosphonate metabolism
AVF2S5_12635	COG0444	Belongs to the ABC transporter superfamily
AVF2S5_12640	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AVF2S5_12645	COG0601	transmembrane transport
AVF2S5_12650	COG0747	negative chemotaxis
AVF2S5_12660	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AVF2S5_12665	COG1802	Transcriptional regulator
AVF2S5_12670	COG1904	glucuronate isomerase
AVF2S5_12675	COG1917	Cupin 2, conserved barrel domain protein
AVF2S5_12685	COG1028	Short-chain dehydrogenase reductase Sdr
AVF2S5_12690	COG0246	Mannitol dehydrogenase
AVF2S5_12695	COG1312	Catalyzes the dehydration of D-mannonate
AVF2S5_12700	COG2721	sulfolactate sulfo-lyase activity
AVF2S5_12710	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
AVF2S5_12725	COG4213	ABC transporter substrate-binding protein
AVF2S5_12735	COG4214	carbohydrate transport
AVF2S5_12745	COG0129	dihydroxy-acid dehydratase activity
AVF2S5_12760	COG3734	2-keto-3-deoxy-galactonokinase
AVF2S5_12765	COG0800	Aldolase
AVF2S5_12770	COG2832	Protein of unknown function (DUF454)
AVF2S5_12775	COG0697	spore germination
AVF2S5_12780	COG2186	Transcriptional regulator
AVF2S5_12785	COG2807	transmembrane transport
AVF2S5_12790	COG2373	Large extracellular alpha-helical protein
AVF2S5_12795	COG4953	penicillin-binding protein 1C
AVF2S5_12800	COG0840	transmembrane signaling receptor activity
AVF2S5_12800	COG2972	Histidine kinase
AVF2S5_12805	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AVF2S5_12810	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AVF2S5_12815	COG0438	transferase activity, transferring glycosyl groups
AVF2S5_12825	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AVF2S5_12830	COG0601	transmembrane transport
AVF2S5_12835	COG0747	negative chemotaxis
AVF2S5_12855	COG0438	transferase activity, transferring glycosyl groups
AVF2S5_12875	COG1132	(ABC) transporter
AVF2S5_12885	COG0419	ATPase involved in DNA repair
AVF2S5_12890	COG0840	transmembrane signaling receptor activity
AVF2S5_12900	COG4372	Transposase
AVF2S5_12910	COG2963	transposase activity
AVF2S5_12955	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
AVF2S5_12965	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AVF2S5_12970	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AVF2S5_12980	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AVF2S5_12995	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AVF2S5_13005	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
AVF2S5_13035	COG0438	transferase activity, transferring glycosyl groups
AVF2S5_13050	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
AVF2S5_13060	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
AVF2S5_13075	COG1793	dna ligase
AVF2S5_13095	COG0783	Belongs to the Dps family
AVF2S5_13105	COG0784	Response regulator, receiver
AVF2S5_13145	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AVF2S5_13160	COG0848	biopolymer transport protein
AVF2S5_13170	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
AVF2S5_13185	COG0010	Belongs to the arginase family
AVF2S5_13205	COG1940	carbohydrate kinase activity
AVF2S5_13225	COG1072	(Pantothenic acid kinase))
AVF2S5_13235	COG0765	amino acid transport
AVF2S5_13240	COG0765	amino acid transport
AVF2S5_13245	COG4598	ABC transporter
AVF2S5_13260	COG0402	S-adenosylhomocysteine deaminase activity
AVF2S5_13265	COG1228	amidohydrolase
AVF2S5_13270	COG2986	histidine ammonia-lyase
AVF2S5_13280	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
AVF2S5_13300	COG1289	transmembrane transporter activity
AVF2S5_13325	COG0346	lactoylglutathione lyase activity
AVF2S5_13330	COG0400	carboxylic ester hydrolase activity
AVF2S5_13350	COG3307	-O-antigen
AVF2S5_13355	COG1596	polysaccharide export
AVF2S5_13360	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AVF2S5_13370	COG1215	transferase activity, transferring glycosyl groups
AVF2S5_13375	COG2327	Polysaccharide pyruvyl transferase
AVF2S5_13380	COG0463	Glycosyl transferase, family 2
AVF2S5_13385	COG2244	polysaccharide biosynthetic process
AVF2S5_13390	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
AVF2S5_13395	COG2273	Hydrolase Family 16
AVF2S5_13400	COG0438	transferase activity, transferring glycosyl groups
AVF2S5_13405	COG1215	transferase activity, transferring glycosyl groups
AVF2S5_13410	COG1215	transferase activity, transferring glycosyl groups
AVF2S5_13415	COG1215	transferase activity, transferring glycosyl groups
AVF2S5_13420	COG0489	protein tyrosine kinase activity
AVF2S5_13420	COG3206	protein involved in exopolysaccharide biosynthesis
AVF2S5_13425	COG0469	pyruvate kinase activity
AVF2S5_13470	COG0542	response to heat
AVF2S5_13480	COG2890	protein-(glutamine-N5) methyltransferase activity
AVF2S5_13485	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
AVF2S5_13495	COG0527	aspartate kinase activity
AVF2S5_13500	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
AVF2S5_13500	COG0392	lysyltransferase activity
AVF2S5_13515	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AVF2S5_13530	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AVF2S5_13535	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
AVF2S5_13545	COG2226	methyltransferase
AVF2S5_13560	COG0494	nUDIX hydrolase
AVF2S5_13570	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
AVF2S5_13575	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AVF2S5_13580	COG0653	protein targeting
AVF2S5_13595	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AVF2S5_13645	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AVF2S5_13655	COG0300	oxidoreductase activity
AVF2S5_13670	COG2086	electron transfer activity
AVF2S5_13680	COG0840	transmembrane signaling receptor activity
AVF2S5_13680	COG2972	Histidine kinase
AVF2S5_13685	COG1250	3-hydroxyacyl-CoA dehydrogenase
AVF2S5_13690	COG0625	glutathione transferase activity
AVF2S5_13695	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AVF2S5_13700	COG0165	Argininosuccinate lyase
AVF2S5_13710	COG0019	diaminopimelate decarboxylase activity
AVF2S5_13725	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
AVF2S5_13735	COG2884	Cell division ATP-binding protein ftsE
AVF2S5_13755	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
AVF2S5_13765	COG0287	Prephenate dehydrogenase
AVF2S5_13770	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AVF2S5_13775	COG2226	methyltransferase
AVF2S5_13780	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AVF2S5_13805	COG0227	Belongs to the bacterial ribosomal protein bL28 family
AVF2S5_13810	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
AVF2S5_13840	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
AVF2S5_13845	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
AVF2S5_13855	COG4974	Belongs to the 'phage' integrase family
AVF2S5_13860	COG0825	malonyl-CoA metabolic process
AVF2S5_13865	COG3034	peptidoglycan biosynthetic process
AVF2S5_13875	COG0523	cobalamin synthesis protein
AVF2S5_13880	COG1686	Belongs to the peptidase S11 family
AVF2S5_13885	COG1473	amidohydrolase
AVF2S5_13895	COG0628	permease
AVF2S5_13905	COG2771	luxR family
AVF2S5_13910	COG1766	The M ring may be actively involved in energy transduction
AVF2S5_13920	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
AVF2S5_13925	COG0745	RESPONSE REGULATOR receiver
AVF2S5_13930	COG2201	protein-glutamate methylesterase activity
AVF2S5_13935	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
AVF2S5_13940	COG0835	chemotaxis
AVF2S5_13945	COG2198	Histidine kinase
AVF2S5_13945	COG0643	Histidine kinase
AVF2S5_13950	COG0745	RESPONSE REGULATOR receiver
AVF2S5_13960	COG0840	transmembrane signaling receptor activity
AVF2S5_13965	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
AVF2S5_13975	COG0156	8-amino-7-oxononanoate synthase activity
AVF2S5_13985	COG0729	surface antigen
AVF2S5_14000	COG0835	chemotaxis
AVF2S5_14005	COG2223	nitrite transmembrane transporter activity
AVF2S5_14015	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
AVF2S5_14020	COG3383	formate dehydrogenase (NAD+) activity
AVF2S5_14035	COG0583	DNA-binding transcription factor activity
AVF2S5_14040	COG0640	Transcriptional regulator
AVF2S5_14045	COG0039	L-malate dehydrogenase activity
AVF2S5_14050	COG0355	proton-transporting ATP synthase activity, rotational mechanism
AVF2S5_14055	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
AVF2S5_14060	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
AVF2S5_14065	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
AVF2S5_14070	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AVF2S5_14085	COG0840	transmembrane signaling receptor activity
AVF2S5_14085	COG2972	Histidine kinase
AVF2S5_14095	COG4974	Belongs to the 'phage' integrase family
AVF2S5_14120	COG0508	dehydrogenase complex catalyzes the overall conversion of
AVF2S5_14130	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
AVF2S5_14140	COG0045	succinate-CoA ligase (ADP-forming) activity
AVF2S5_14145	COG0039	L-malate dehydrogenase activity
AVF2S5_14150	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
AVF2S5_14195	COG2350	Protein conserved in bacteria
AVF2S5_14200	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
AVF2S5_14205	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
AVF2S5_14210	COG0181	hydroxymethylbilane synthase activity
AVF2S5_14250	COG1872	DUF167
AVF2S5_14255	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
AVF2S5_14265	COG1217	gtp-binding protein TYPA
AVF2S5_14275	COG0339	signal peptide processing
AVF2S5_14295	COG0137	argininosuccinate synthase activity
AVF2S5_14300	COG1028	Short-chain dehydrogenase reductase Sdr
AVF2S5_14310	COG1280	lysine exporter protein (LysE YggA)
AVF2S5_14320	COG0820	rRNA (adenine-C2-)-methyltransferase activity
AVF2S5_14335	COG2154	pterin-4-alpha-carbinolamine dehydratase
AVF2S5_14340	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
AVF2S5_14350	COG1136	(ABC) transporter
AVF2S5_14355	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
AVF2S5_14360	COG0670	Belongs to the BI1 family
AVF2S5_14380	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
AVF2S5_14385	COG4133	protoheme IX ABC transporter activity
AVF2S5_14390	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AVF2S5_14395	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AVF2S5_14415	COG2917	probably involved in intracellular septation
AVF2S5_14420	COG0552	protein localization to endoplasmic reticulum
AVF2S5_14425	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AVF2S5_14430	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
AVF2S5_14445	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
AVF2S5_14450	COG0287	Prephenate dehydrogenase
AVF2S5_14450	COG1605	Chorismate mutase
AVF2S5_14455	COG0228	four-way junction DNA binding
AVF2S5_14460	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
AVF2S5_14465	COG0336	Belongs to the RNA methyltransferase TrmD family
AVF2S5_14475	COG0335	large ribosomal subunit rRNA binding
AVF2S5_14490	COG2372	response to copper ion
AVF2S5_14495	COG1276	copper resistance
AVF2S5_14505	COG0765	amino acid transport
AVF2S5_14520	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AVF2S5_14535	COG0745	RESPONSE REGULATOR receiver
AVF2S5_14555	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
AVF2S5_14560	COG1674	ftsk spoiiie
AVF2S5_14565	COG0004	ammonium transporteR
AVF2S5_14570	COG0347	Belongs to the P(II) protein family
AVF2S5_14575	COG1946	Acyl-CoA thioesterase
AVF2S5_14580	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AVF2S5_14585	COG2835	tetraacyldisaccharide 4'-kinase activity
AVF2S5_14590	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
AVF2S5_14595	COG3118	belongs to the thioredoxin family
AVF2S5_14615	COG2017	converts alpha-aldose to the beta-anomer
AVF2S5_14630	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
AVF2S5_14635	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AVF2S5_14645	COG0828	Belongs to the bacterial ribosomal protein bS21 family
AVF2S5_14655	COG0488	(ABC) transporter
AVF2S5_14685	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
AVF2S5_14715	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
AVF2S5_14720	COG0799	negative regulation of ribosome biogenesis
AVF2S5_14725	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
AVF2S5_14730	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
AVF2S5_14735	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
AVF2S5_14740	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AVF2S5_14760	COG0211	Belongs to the bacterial ribosomal protein bL27 family
AVF2S5_14765	COG0261	This protein binds to 23S rRNA in the presence of protein L20
AVF2S5_14785	COG0138	bifunctional purine biosynthesis protein purh
AVF2S5_14795	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AVF2S5_14795	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AVF2S5_14800	COG0501	Belongs to the peptidase M48B family
AVF2S5_14815	COG0793	Belongs to the peptidase S41A family
AVF2S5_14825	COG0494	nUDIX hydrolase
AVF2S5_14830	COG1192	Involved in chromosome partitioning
AVF2S5_14855	COG2201	protein-glutamate methylesterase activity
AVF2S5_14860	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
AVF2S5_14865	COG0835	chemotaxis
AVF2S5_14870	COG0840	transmembrane signaling receptor activity
AVF2S5_14875	COG0840	transmembrane signaling receptor activity
AVF2S5_14875	COG3290	protein histidine kinase activity
AVF2S5_14880	COG0840	transmembrane signaling receptor activity
AVF2S5_14885	COG0835	chemotaxis
AVF2S5_14890	COG0643	Histidine kinase
AVF2S5_14890	COG2198	Histidine kinase
AVF2S5_14895	COG0745	RESPONSE REGULATOR receiver
AVF2S5_14920	COG1522	sequence-specific DNA binding
AVF2S5_14935	COG4221	oxidoreductase activity
AVF2S5_14950	COG0738	Major facilitator superfamily
AVF2S5_14955	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
AVF2S5_14960	COG2885	chlorophyll binding
AVF2S5_14970	COG0142	geranyltranstransferase activity
AVF2S5_14975	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AVF2S5_14985	COG0333	Belongs to the bacterial ribosomal protein bL32 family
AVF2S5_14990	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
AVF2S5_14995	COG0183	Belongs to the thiolase family
AVF2S5_15030	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
AVF2S5_15060	COG0066	3-isopropylmalate dehydratase activity
AVF2S5_15065	COG0473	3-isopropylmalate dehydrogenase activity
AVF2S5_15070	COG0671	phosphoesterase, PA-phosphatase related
AVF2S5_15080	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AVF2S5_15090	COG2010	Cytochrome c
AVF2S5_15095	COG0288	reversible hydration of carbon dioxide
AVF2S5_15100	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
AVF2S5_15105	COG2902	Dehydrogenase
AVF2S5_15120	COG3459	Glycosyltransferase 36 associated
AVF2S5_15125	COG1473	amidohydrolase
AVF2S5_15140	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
AVF2S5_15150	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AVF2S5_15160	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
AVF2S5_15165	COG0495	leucyl-tRNA aminoacylation
AVF2S5_15190	COG0357	Ribosomal RNA small subunit methyltransferase G
AVF2S5_15195	COG0445	tRNA wobble uridine modification
AVF2S5_15200	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
AVF2S5_15205	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
AVF2S5_15210	COG1981	membrane
AVF2S5_15215	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
AVF2S5_15220	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
AVF2S5_15225	COG0424	maF-like protein
AVF2S5_15230	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AVF2S5_15235	COG0237	dephospho-CoA kinase activity
AVF2S5_15245	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
AVF2S5_15260	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
AVF2S5_15300	COG0135	phosphoribosylanthranilate isomerase activity
AVF2S5_15305	COG0133	tryptophan synthase activity
AVF2S5_15310	COG0159	tryptophan synthase activity
AVF2S5_15315	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
AVF2S5_15320	COG0285	dihydrofolate synthase activity
AVF2S5_15330	COG2226	methyltransferase
AVF2S5_15345	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
AVF2S5_15350	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
AVF2S5_15355	COG0131	Imidazoleglycerol-phosphate dehydratase
AVF2S5_15360	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
AVF2S5_15365	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
AVF2S5_15370	COG0107	imidazoleglycerol-phosphate synthase activity
AVF2S5_15375	COG0140	phosphoribosyl-ATP diphosphatase activity
AVF2S5_15380	COG1072	(Pantothenic acid kinase))
AVF2S5_15395	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
AVF2S5_15400	COG0745	RESPONSE REGULATOR receiver
AVF2S5_15405	COG0642	Histidine kinase
AVF2S5_15415	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AVF2S5_15415	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
AVF2S5_15420	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AVF2S5_15425	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
AVF2S5_15430	COG2205	protein histidine kinase activity
AVF2S5_15435	COG3178	'Phosphotransferase
AVF2S5_15440	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
AVF2S5_15450	COG1074	ATP-dependent DNA helicase activity
AVF2S5_15455	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
AVF2S5_15470	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
AVF2S5_15480	COG1643	Atp-dependent helicase
AVF2S5_15485	COG2423	ornithine cyclodeaminase activity
AVF2S5_15525	COG2963	transposase activity
AVF2S5_15535	COG4372	Transposase
AVF2S5_15550	COG2814	Major facilitator Superfamily
AVF2S5_15555	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AVF2S5_15560	COG1609	Transcriptional regulator
AVF2S5_15570	COG0673	inositol 2-dehydrogenase activity
AVF2S5_15580	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AVF2S5_15585	COG3962	Belongs to the TPP enzyme family
AVF2S5_15600	COG3718	enzyme involved in inositol metabolism
AVF2S5_15625	COG4221	oxidoreductase activity
AVF2S5_15630	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AVF2S5_15645	COG1595	DNA-templated transcription, initiation
AVF2S5_15650	COG3806	Anti-sigma factor
AVF2S5_15670	COG3842	ATPase activity
AVF2S5_15675	COG3842	ATPase activity
AVF2S5_15685	COG0395	ABC-type sugar transport system, permease component
AVF2S5_15700	COG3474	cytochrome
AVF2S5_15705	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
AVF2S5_15710	COG0077	Prephenate dehydratase
AVF2S5_15710	COG1605	Chorismate mutase
AVF2S5_15720	COG2816	NAD+ diphosphatase activity
AVF2S5_15735	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
AVF2S5_15740	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
AVF2S5_15760	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AVF2S5_15765	COG0481	GTPase activity
AVF2S5_15780	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AVF2S5_15785	COG1607	acyl-coa hydrolase
AVF2S5_15810	COG1393	Belongs to the ArsC family
AVF2S5_15815	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
AVF2S5_15820	COG2309	aminopeptidase activity
AVF2S5_15835	COG1278	Cold shock
AVF2S5_15840	COG1570	exodeoxyribonuclease VII activity
AVF2S5_15880	COG0667	Aldo Keto reductase
AVF2S5_15890	COG2814	Major facilitator Superfamily
AVF2S5_15895	COG0583	DNA-binding transcription factor activity
AVF2S5_15905	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AVF2S5_15910	COG2951	lytic endotransglycosylase activity
AVF2S5_15935	COG2814	Major facilitator Superfamily
AVF2S5_15945	COG0779	Required for maturation of 30S ribosomal subunits
AVF2S5_15950	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AVF2S5_15950	COG0195	Participates in both transcription termination and antitermination
AVF2S5_15960	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
AVF2S5_15965	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
AVF2S5_15970	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AVF2S5_15975	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
AVF2S5_15980	COG1185	polyribonucleotide nucleotidyltransferase activity
AVF2S5_15990	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
AVF2S5_16000	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AVF2S5_16010	COG2860	membrane
AVF2S5_16020	COG0477	Major facilitator Superfamily
AVF2S5_16035	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
AVF2S5_16040	COG0539	negative regulation of cytoplasmic translation
AVF2S5_16060	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
AVF2S5_16075	COG0291	Belongs to the bacterial ribosomal protein bL35 family
AVF2S5_16080	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
AVF2S5_16085	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
AVF2S5_16100	COG0072	phenylalanine-tRNA ligase activity
AVF2S5_16100	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AVF2S5_16145	COG4964	Belongs to the GSP D family
AVF2S5_16185	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
AVF2S5_16190	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
AVF2S5_16195	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
AVF2S5_16205	COG0588	phosphoglycerate mutase activity
AVF2S5_16210	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
AVF2S5_16215	COG1132	(ABC) transporter
AVF2S5_16220	COG0837	glucose binding
AVF2S5_16225	COG1803	Methylglyoxal synthase
AVF2S5_16230	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
AVF2S5_16235	COG4166	transmembrane transport
AVF2S5_16240	COG4174	ABC transporter (Permease)
AVF2S5_16245	COG4239	(ABC) transporter, permease
AVF2S5_16250	COG4172	Belongs to the ABC transporter superfamily
AVF2S5_16265	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
AVF2S5_16290	COG1802	Transcriptional regulator
AVF2S5_16290	COG4626	Terminase
AVF2S5_16360	COG1744	ABC transporter substrate-binding protein PnrA-like
AVF2S5_16365	COG3845	ABC transporter
AVF2S5_16370	COG1079	Belongs to the binding-protein-dependent transport system permease family
AVF2S5_16375	COG1079	Belongs to the binding-protein-dependent transport system permease family
AVF2S5_16390	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
AVF2S5_16395	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
AVF2S5_16400	COG2188	Transcriptional regulator
AVF2S5_16405	COG3624	Phosphonate C-P lyase system protein PhnG
AVF2S5_16410	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
AVF2S5_16415	COG3626	phosphonate metabolism
AVF2S5_16420	COG3627	carbon phosphorus lyase activity
AVF2S5_16425	COG4107	phosphonate C-P lyase system protein PhnK
AVF2S5_16430	COG4778	phosphonate C-P lyase system protein PhnL
AVF2S5_16440	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
AVF2S5_16445	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
AVF2S5_16455	COG3639	organic phosphonate transmembrane transporter activity
AVF2S5_16460	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
AVF2S5_16465	COG3454	Phosphonate metabolism
AVF2S5_16470	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
AVF2S5_16485	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AVF2S5_16490	COG2353	YceI-like domain
AVF2S5_16495	COG2353	YceI-like domain
AVF2S5_16505	COG0791	NLP P60 protein
AVF2S5_16510	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AVF2S5_16510	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AVF2S5_16520	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AVF2S5_16525	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
AVF2S5_16540	COG0443	Heat shock 70 kDa protein
AVF2S5_16550	COG0484	heat shock protein binding
AVF2S5_16555	COG2900	Belongs to the SlyX family
AVF2S5_16560	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AVF2S5_16575	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AVF2S5_16585	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AVF2S5_16590	COG3300	MHYT domain
AVF2S5_16590	COG5001	Diguanylate cyclase
AVF2S5_16595	COG3002	Belongs to the UPF0753 family
AVF2S5_16620	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AVF2S5_16620	COG0519	Catalyzes the synthesis of GMP from XMP
AVF2S5_16665	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
AVF2S5_16675	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
AVF2S5_16685	COG1968	undecaprenyl-diphosphatase activity
AVF2S5_16710	COG0284	orotidine-5'-phosphate decarboxylase activity
AVF2S5_16720	COG3963	phosphatidate phosphatase activity
AVF2S5_16730	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
AVF2S5_16735	COG0792	nuclease activity
AVF2S5_16745	COG1175	transmembrane transport
AVF2S5_16750	COG0395	ABC-type sugar transport system, permease component
AVF2S5_16755	COG3842	ATPase activity
AVF2S5_16765	COG0189	ligase activity
AVF2S5_16770	COG0606	chelatase, subunit chli
AVF2S5_16785	COG1280	lysine exporter protein (LysE YggA)
AVF2S5_16790	COG0756	dUTP diphosphatase activity
AVF2S5_16795	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
AVF2S5_16800	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
AVF2S5_16805	COG1877	trehalose-phosphatase activity
AVF2S5_16825	COG1741	Belongs to the pirin family
AVF2S5_16835	COG0583	DNA-binding transcription factor activity
AVF2S5_16850	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AVF2S5_16855	COG3920	Histidine kinase
AVF2S5_16860	COG0784	Response regulator, receiver
AVF2S5_16865	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AVF2S5_16865	COG2198	Histidine kinase
AVF2S5_16865	COG2205	protein histidine kinase activity
AVF2S5_16865	COG0784	Response regulator, receiver
AVF2S5_16870	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AVF2S5_16875	COG2226	methyltransferase
AVF2S5_16880	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AVF2S5_16885	COG0268	Binds directly to 16S ribosomal RNA
AVF2S5_16895	COG1192	Involved in chromosome partitioning
AVF2S5_16900	COG1475	DNA binding
AVF2S5_16905	COG1414	Transcriptional regulator
AVF2S5_16910	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AVF2S5_16915	COG0392	lysyltransferase activity
AVF2S5_16940	COG3257	ureidoglycine aminohydrolase activity
AVF2S5_16960	COG1522	sequence-specific DNA binding
AVF2S5_16975	COG4215	(ABC) transporter
AVF2S5_16985	COG2040	homocysteine
AVF2S5_16990	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AVF2S5_17000	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
AVF2S5_17005	COG1473	amidohydrolase
AVF2S5_17015	COG0297	glycogen (starch) synthase activity
AVF2S5_17040	COG1063	alcohol dehydrogenase
AVF2S5_17045	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AVF2S5_17050	COG1028	Short-chain dehydrogenase reductase Sdr
AVF2S5_17055	COG3265	gluconokinase activity
AVF2S5_17060	COG2084	Dehydrogenase
AVF2S5_17070	COG1609	Transcriptional regulator
AVF2S5_17085	COG1129	ABC transporter
AVF2S5_17105	COG1879	ABC-type sugar transport system periplasmic component
AVF2S5_17110	COG1129	ABC transporter
AVF2S5_17115	COG1172	Belongs to the binding-protein-dependent transport system permease family
AVF2S5_17120	COG1172	Belongs to the binding-protein-dependent transport system permease family
AVF2S5_17125	COG2186	Transcriptional regulator
AVF2S5_17130	COG1012	belongs to the aldehyde dehydrogenase family
AVF2S5_17135	COG1012	belongs to the aldehyde dehydrogenase family
AVF2S5_17145	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AVF2S5_17155	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AVF2S5_17160	COG1116	anion transmembrane transporter activity
AVF2S5_17180	COG0778	Nitroreductase
AVF2S5_17190	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AVF2S5_17195	COG0659	secondary active sulfate transmembrane transporter activity
AVF2S5_17200	COG0589	response to stress
AVF2S5_17260	COG0179	Fumarylacetoacetate (FAA) hydrolase
AVF2S5_17275	COG1802	Transcriptional regulator
AVF2S5_17280	COG0747	negative chemotaxis
AVF2S5_17285	COG2723	6-phospho-beta-galactosidase activity
AVF2S5_17290	COG0601	transmembrane transport
AVF2S5_17300	COG3964	amidohydrolase
AVF2S5_17315	COG1921	L-seryl-tRNASec selenium transferase activity
AVF2S5_17320	COG2203	Gaf domain
AVF2S5_17320	COG5001	Diguanylate cyclase
AVF2S5_17320	COG3706	GGDEF domain
AVF2S5_17320	COG4251	negative regulation of phosphorylation
AVF2S5_17335	COG2080	2 iron, 2 sulfur cluster binding
AVF2S5_17340	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
AVF2S5_17345	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AVF2S5_17370	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AVF2S5_17375	COG1486	melibiose metabolic process
AVF2S5_17380	COG4172	Belongs to the ABC transporter superfamily
AVF2S5_17385	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AVF2S5_17390	COG0601	transmembrane transport
AVF2S5_17395	COG0747	negative chemotaxis
AVF2S5_17400	COG1486	melibiose metabolic process
AVF2S5_17405	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AVF2S5_17405	COG2207	Transcriptional regulator
AVF2S5_17435	COG1063	alcohol dehydrogenase
AVF2S5_17440	COG4948	Mandelate Racemase Muconate Lactonizing
AVF2S5_17460	COG4214	carbohydrate transport
AVF2S5_17465	COG1129	ABC transporter
AVF2S5_17480	COG1175	transmembrane transport
AVF2S5_17485	COG0395	ABC-type sugar transport system, permease component
AVF2S5_17505	COG1609	Transcriptional regulator
AVF2S5_17520	COG1172	Belongs to the binding-protein-dependent transport system permease family
AVF2S5_17535	COG0840	transmembrane signaling receptor activity
AVF2S5_17535	COG2972	Histidine kinase
AVF2S5_17560	COG0667	Aldo Keto reductase
AVF2S5_17575	COG1172	Belongs to the binding-protein-dependent transport system permease family
AVF2S5_17585	COG4213	ABC transporter substrate-binding protein
AVF2S5_17600	COG1129	ABC transporter
AVF2S5_17605	COG1172	Belongs to the binding-protein-dependent transport system permease family
AVF2S5_17610	COG1172	Belongs to the binding-protein-dependent transport system permease family
AVF2S5_17615	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AVF2S5_17630	COG0765	amino acid transport
AVF2S5_17635	COG1126	abc transporter atp-binding protein
AVF2S5_17640	COG2079	MmgE PrpD family protein
AVF2S5_17645	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AVF2S5_17660	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AVF2S5_17670	COG4172	Belongs to the ABC transporter superfamily
AVF2S5_17675	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AVF2S5_17700	COG2197	response regulator
AVF2S5_17705	COG3850	Histidine kinase
AVF2S5_17705	COG5002	protein histidine kinase activity
AVF2S5_17710	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
AVF2S5_17720	COG2731	YhcH YjgK YiaL family protein
AVF2S5_17725	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AVF2S5_17730	COG2271	Major facilitator Superfamily
AVF2S5_17735	COG1609	Transcriptional regulator
AVF2S5_17740	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AVF2S5_17745	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AVF2S5_17750	COG1473	amidohydrolase
AVF2S5_17765	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AVF2S5_17775	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AVF2S5_17795	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AVF2S5_17815	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AVF2S5_17825	COG1960	acyl-CoA dehydrogenase activity
AVF2S5_17835	COG1309	transcriptional regulator
AVF2S5_17865	COG2207	Transcriptional regulator
AVF2S5_17875	COG0235	Class ii aldolase
AVF2S5_17895	COG0300	oxidoreductase activity
AVF2S5_17925	COG1595	DNA-templated transcription, initiation
AVF2S5_17935	COG2824	Alkylphosphonate utilization operon protein PhnA
AVF2S5_17960	COG3833	ABC-type maltose transport systems, permease component
AVF2S5_17965	COG3842	ATPase activity
AVF2S5_17970	COG0584	glycerophosphoryl diester phosphodiesterase
AVF2S5_18010	COG1320	monovalent cation:proton antiporter activity
AVF2S5_18015	COG2212	antiporter activity
AVF2S5_18020	COG1863	multisubunit Na H antiporter MnhE subunit
AVF2S5_18025	COG0651	ATP synthesis coupled electron transport
AVF2S5_18030	COG1006	Multisubunit Na H antiporter MnhC subunit
AVF2S5_18035	COG2111	Na H antiporter
AVF2S5_18035	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AVF2S5_18055	COG3845	ABC transporter
AVF2S5_18060	COG4603	Belongs to the binding-protein-dependent transport system permease family
AVF2S5_18065	COG1079	Belongs to the binding-protein-dependent transport system permease family
AVF2S5_18070	COG0402	S-adenosylhomocysteine deaminase activity
AVF2S5_18075	COG0402	S-adenosylhomocysteine deaminase activity
AVF2S5_18090	COG2072	flavoprotein involved in K transport
AVF2S5_18095	COG1177	transmembrane transport
AVF2S5_18100	COG1176	ABC-type spermidine putrescine transport system, permease component I
AVF2S5_18105	COG3842	ATPase activity
AVF2S5_18110	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
AVF2S5_18115	COG0583	DNA-binding transcription factor activity
AVF2S5_18140	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AVF2S5_18145	COG0444	Belongs to the ABC transporter superfamily
AVF2S5_18175	COG0601	transmembrane transport
AVF2S5_18180	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AVF2S5_18200	COG1172	Belongs to the binding-protein-dependent transport system permease family
AVF2S5_18205	COG1028	Short-chain dehydrogenase reductase Sdr
AVF2S5_18210	COG1846	Transcriptional regulator
AVF2S5_18240	COG0625	glutathione transferase activity
AVF2S5_18260	COG2133	pyrroloquinoline quinone binding
AVF2S5_18270	COG0438	transferase activity, transferring glycosyl groups
AVF2S5_18285	COG0753	catalase activity
AVF2S5_18290	COG0306	phosphate transporter
AVF2S5_18300	COG3842	ATPase activity
AVF2S5_18305	COG1175	transmembrane transport
AVF2S5_18310	COG0395	ABC-type sugar transport system, permease component
AVF2S5_18335	COG3684	Belongs to the aldolase LacD family
AVF2S5_18340	COG2390	Transcriptional regulator
AVF2S5_18360	COG1028	Short-chain dehydrogenase reductase Sdr
AVF2S5_18365	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AVF2S5_18370	COG0626	cystathionine gamma-synthase activity
AVF2S5_18375	COG1725	Transcriptional regulator
AVF2S5_18380	COG0747	negative chemotaxis
AVF2S5_18385	COG0601	transmembrane transport
AVF2S5_18390	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AVF2S5_18395	COG0444	Belongs to the ABC transporter superfamily
AVF2S5_18400	COG4608	Belongs to the ABC transporter superfamily
AVF2S5_18405	COG0006	proline dipeptidase activity
AVF2S5_18415	COG0747	negative chemotaxis
AVF2S5_18425	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AVF2S5_18430	COG0405	Gamma-glutamyltransferase
AVF2S5_18440	COG0754	glutathionylspermidine amidase activity
AVF2S5_18450	COG3766	membrane
AVF2S5_18460	COG3789	protein conserved in bacteria
AVF2S5_18475	COG0318	PFAM AMP-dependent synthetase and ligase
AVF2S5_18485	COG1802	Transcriptional regulator
AVF2S5_18495	COG0601	transmembrane transport
AVF2S5_18500	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AVF2S5_18525	COG0747	negative chemotaxis
AVF2S5_18535	COG2205	protein histidine kinase activity
AVF2S5_18540	COG2197	response regulator
AVF2S5_18545	COG4585	Histidine kinase
AVF2S5_18560	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
AVF2S5_18565	COG4208	sulfate ABC transporter
AVF2S5_18570	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
AVF2S5_18575	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
AVF2S5_18580	COG1609	Transcriptional regulator
AVF2S5_18585	COG0673	inositol 2-dehydrogenase activity
AVF2S5_18595	COG1653	transport
AVF2S5_18600	COG1175	transmembrane transport
AVF2S5_18605	COG0395	ABC-type sugar transport system, permease component
AVF2S5_18610	COG3842	ATPase activity
AVF2S5_18620	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
AVF2S5_18635	COG0583	DNA-binding transcription factor activity
AVF2S5_18640	COG0402	S-adenosylhomocysteine deaminase activity
AVF2S5_18645	COG3250	beta-galactosidase activity
AVF2S5_18650	COG1940	carbohydrate kinase activity
AVF2S5_18655	COG2116	formate transmembrane transporter activity
AVF2S5_18660	COG0402	S-adenosylhomocysteine deaminase activity
AVF2S5_18670	COG1079	Belongs to the binding-protein-dependent transport system permease family
AVF2S5_18675	COG4603	Belongs to the binding-protein-dependent transport system permease family
AVF2S5_18680	COG3845	ABC transporter
AVF2S5_18705	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
AVF2S5_18725	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
AVF2S5_18730	COG0402	S-adenosylhomocysteine deaminase activity
AVF2S5_18740	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AVF2S5_18745	COG2080	2 iron, 2 sulfur cluster binding
AVF2S5_18750	COG1012	belongs to the aldehyde dehydrogenase family
AVF2S5_18765	COG2186	Transcriptional regulator
AVF2S5_18770	COG1304	FMN binding
AVF2S5_18780	COG0179	Fumarylacetoacetate (FAA) hydrolase
AVF2S5_18825	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
AVF2S5_18830	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AVF2S5_18835	COG1126	abc transporter atp-binding protein
AVF2S5_18840	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AVF2S5_18845	COG0765	amino acid transport
AVF2S5_18850	COG0765	amino acid transport
AVF2S5_18855	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
AVF2S5_18865	COG1764	response to oxidative stress
AVF2S5_18880	COG1116	anion transmembrane transporter activity
AVF2S5_18885	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AVF2S5_18890	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AVF2S5_18895	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AVF2S5_18900	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AVF2S5_18905	COG1959	2 iron, 2 sulfur cluster binding
AVF2S5_18930	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AVF2S5_18985	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AVF2S5_18995	COG1116	anion transmembrane transporter activity
AVF2S5_19005	COG4191	Histidine kinase
AVF2S5_19010	COG4566	intracellular signal transduction
AVF2S5_19020	COG3842	ATPase activity
AVF2S5_19025	COG0395	ABC-type sugar transport system, permease component
AVF2S5_19030	COG1175	transmembrane transport
AVF2S5_19065	COG1940	carbohydrate kinase activity
AVF2S5_19070	COG0747	negative chemotaxis
AVF2S5_19075	COG0601	transmembrane transport
AVF2S5_19080	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AVF2S5_19090	COG4608	Belongs to the ABC transporter superfamily
AVF2S5_19100	COG2205	protein histidine kinase activity
AVF2S5_19110	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
AVF2S5_19120	COG2076	Multidrug Resistance protein
AVF2S5_19140	COG2076	Multidrug Resistance protein
AVF2S5_19155	COG1215	transferase activity, transferring glycosyl groups
AVF2S5_19170	COG2202	Pas domain
AVF2S5_19170	COG3920	Histidine kinase
AVF2S5_19180	COG0784	Response regulator, receiver
AVF2S5_19190	COG1162	GTPase activity
AVF2S5_19195	COG0784	Response regulator, receiver
AVF2S5_19195	COG4191	Histidine kinase
AVF2S5_19200	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AVF2S5_19215	COG1126	abc transporter atp-binding protein
AVF2S5_19220	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AVF2S5_19225	COG1609	Transcriptional regulator
AVF2S5_19230	COG0840	transmembrane signaling receptor activity
AVF2S5_19230	COG2972	Histidine kinase
AVF2S5_19235	COG0835	chemotaxis
AVF2S5_19245	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AVF2S5_19260	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AVF2S5_19270	COG0789	Transcriptional regulator
AVF2S5_19275	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
AVF2S5_19280	COG0366	Alpha amylase catalytic
AVF2S5_19285	COG0366	Alpha amylase catalytic
AVF2S5_19290	COG1640	4-alpha-glucanotransferase
AVF2S5_19295	COG1278	Cold shock
AVF2S5_19300	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AVF2S5_19310	COG0673	inositol 2-dehydrogenase activity
AVF2S5_19320	COG1802	Transcriptional regulator
AVF2S5_19325	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AVF2S5_19335	COG0673	inositol 2-dehydrogenase activity
AVF2S5_19345	COG1175	transmembrane transport
AVF2S5_19350	COG0395	ABC-type sugar transport system, permease component
AVF2S5_19360	COG0673	inositol 2-dehydrogenase activity
AVF2S5_19370	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
AVF2S5_19380	COG1028	Short-chain dehydrogenase reductase Sdr
AVF2S5_19390	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
AVF2S5_19395	COG3920	Histidine kinase
AVF2S5_19410	COG3685	Protein conserved in bacteria
AVF2S5_19440	COG5001	Diguanylate cyclase
AVF2S5_19445	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
AVF2S5_19465	COG1132	(ABC) transporter
AVF2S5_19470	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AVF2S5_19470	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AVF2S5_19485	COG3842	ATPase activity
AVF2S5_19490	COG3833	ABC-type maltose transport systems, permease component
AVF2S5_19505	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AVF2S5_19535	COG0604	alcohol dehydrogenase
AVF2S5_19535	COG3321	synthase
AVF2S5_19555	COG1960	acyl-CoA dehydrogenase activity
AVF2S5_19565	COG4608	Belongs to the ABC transporter superfamily
AVF2S5_19580	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AVF2S5_19585	COG0747	negative chemotaxis
AVF2S5_19605	COG0583	DNA-binding transcription factor activity
AVF2S5_19610	COG0747	negative chemotaxis
AVF2S5_19620	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AVF2S5_19635	COG0154	amidase activity
AVF2S5_19650	COG1335	isochorismatase
AVF2S5_19655	COG3845	ABC transporter
AVF2S5_19670	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AVF2S5_19675	COG1079	Belongs to the binding-protein-dependent transport system permease family
AVF2S5_19695	COG4172	Belongs to the ABC transporter superfamily
AVF2S5_19700	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AVF2S5_19705	COG0601	transmembrane transport
AVF2S5_19735	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AVF2S5_19740	COG1012	belongs to the aldehyde dehydrogenase family
AVF2S5_19750	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AVF2S5_19755	COG1309	transcriptional regulator
AVF2S5_19770	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AVF2S5_19785	COG4770	biotin carboxylase activity
AVF2S5_19800	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AVF2S5_19800	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AVF2S5_19825	COG0179	Fumarylacetoacetate (FAA) hydrolase
AVF2S5_19830	COG1028	Short-chain dehydrogenase reductase Sdr
AVF2S5_19835	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
AVF2S5_19835	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AVF2S5_19840	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AVF2S5_19850	COG4172	Belongs to the ABC transporter superfamily
AVF2S5_19855	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AVF2S5_19860	COG0601	transmembrane transport
AVF2S5_19865	COG0747	negative chemotaxis
AVF2S5_19870	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AVF2S5_19875	COG2186	Transcriptional regulator
AVF2S5_19885	COG0640	Transcriptional regulator
AVF2S5_19895	COG3842	ATPase activity
AVF2S5_19900	COG1175	transmembrane transport
AVF2S5_19905	COG0395	ABC-type sugar transport system, permease component
AVF2S5_19915	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
AVF2S5_19925	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AVF2S5_19930	COG1012	belongs to the aldehyde dehydrogenase family
AVF2S5_19935	COG2084	Dehydrogenase
AVF2S5_19945	COG3386	PFAM SMP-30 Gluconolaconase
AVF2S5_19955	COG2771	luxR family
AVF2S5_19965	COG0626	cystathionine gamma-synthase activity
AVF2S5_19980	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AVF2S5_20015	COG1175	transmembrane transport
AVF2S5_20020	COG0395	ABC-type sugar transport system, permease component
AVF2S5_20045	COG0446	pyridine nucleotide-disulphide oxidoreductase
AVF2S5_20045	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AVF2S5_20050	COG4311	Sarcosine oxidase, delta subunit
AVF2S5_20055	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AVF2S5_20060	COG4977	sequence-specific DNA binding
AVF2S5_20070	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
AVF2S5_20075	COG2218	PFAM glutamate synthase alpha subunit domain protein
AVF2S5_20080	COG0069	glutamate synthase activity
AVF2S5_20095	COG1304	FMN binding
AVF2S5_20110	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
AVF2S5_20125	COG1175	transmembrane transport
AVF2S5_20130	COG0395	ABC-type sugar transport system, permease component
AVF2S5_20135	COG1609	Transcriptional regulator
AVF2S5_20150	COG0412	Dienelactone hydrolase
AVF2S5_20160	COG0583	DNA-binding transcription factor activity
AVF2S5_20170	COG0583	DNA-binding transcription factor activity
AVF2S5_20195	COG0306	phosphate transporter
AVF2S5_20210	COG0277	FAD linked oxidase domain protein
AVF2S5_20215	COG0277	FAD linked oxidase domain protein
AVF2S5_20220	COG0247	lactate metabolic process
AVF2S5_20230	COG0625	glutathione transferase activity
AVF2S5_20240	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
AVF2S5_20245	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
AVF2S5_20270	COG0124	histidyl-tRNA synthetase
AVF2S5_20300	COG2818	Glycosylase
AVF2S5_20305	COG1376	ErfK ybiS ycfS ynhG family protein
AVF2S5_20305	COG1388	LysM domain
AVF2S5_20310	COG1376	ErfK ybiS ycfS ynhG family protein
AVF2S5_20315	COG2909	trisaccharide binding
AVF2S5_20320	COG2977	Belongs to the P-Pant transferase superfamily
AVF2S5_20325	COG2137	regulation of response to DNA damage stimulus
AVF2S5_20330	COG2130	NADP-dependent
AVF2S5_20345	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AVF2S5_20360	COG0196	riboflavin kinase activity
AVF2S5_20370	COG2059	Chromate
AVF2S5_20375	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
AVF2S5_20380	COG0459	protein refolding
AVF2S5_20400	COG3842	ATPase activity
AVF2S5_20410	COG1176	ABC-type spermidine putrescine transport system, permease component I
AVF2S5_20415	COG1177	transmembrane transport
AVF2S5_20420	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
AVF2S5_20425	COG0019	diaminopimelate decarboxylase activity
AVF2S5_20435	COG4770	biotin carboxylase activity
AVF2S5_20440	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
AVF2S5_20445	COG4336	lyase activity
AVF2S5_20450	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
AVF2S5_20455	COG1914	H( )-stimulated, divalent metal cation uptake system
AVF2S5_20460	COG1802	Transcriptional regulator
AVF2S5_20465	COG1522	sequence-specific DNA binding
AVF2S5_20470	COG2515	1-aminocyclopropane-1-carboxylate deaminase
AVF2S5_20495	COG0583	DNA-binding transcription factor activity
AVF2S5_20500	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
AVF2S5_20505	COG0511	ligase activity, forming carbon-carbon bonds
AVF2S5_20510	COG0439	Biotin carboxylase
AVF2S5_20520	COG1984	allophanate hydrolase subunit 2
AVF2S5_20530	COG3842	ATPase activity
AVF2S5_20535	COG1176	ABC-type spermidine putrescine transport system, permease component I
AVF2S5_20545	COG1028	Short-chain dehydrogenase reductase Sdr
AVF2S5_20550	COG1028	Short-chain dehydrogenase reductase Sdr
AVF2S5_20560	COG3842	ATPase activity
AVF2S5_20565	COG0726	polysaccharide deacetylase
AVF2S5_20575	COG0523	cobalamin synthesis protein
AVF2S5_20590	COG1522	sequence-specific DNA binding
AVF2S5_20600	COG0659	secondary active sulfate transmembrane transporter activity
AVF2S5_20610	COG0243	molybdopterin cofactor binding
AVF2S5_20620	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AVF2S5_20625	COG1116	anion transmembrane transporter activity
AVF2S5_20630	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AVF2S5_20635	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AVF2S5_20640	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AVF2S5_20645	COG3707	response regulator
AVF2S5_20665	COG0583	DNA-binding transcription factor activity
AVF2S5_20670	COG1960	acyl-CoA dehydrogenase activity
AVF2S5_20675	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AVF2S5_20690	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AVF2S5_20705	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
AVF2S5_20720	COG2022	thiamine diphosphate biosynthetic process
AVF2S5_20765	COG2963	transposase activity
AVF2S5_20775	COG2963	transposase activity
AVF2S5_20825	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
AVF2S5_20825	COG2070	2-Nitropropane dioxygenase
AVF2S5_20830	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AVF2S5_20835	COG0367	asparagine synthase
AVF2S5_20840	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AVF2S5_20840	COG0300	oxidoreductase activity
AVF2S5_20840	COG3321	synthase
AVF2S5_20840	COG4221	oxidoreductase activity
AVF2S5_20845	COG3321	synthase
AVF2S5_20845	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AVF2S5_20845	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AVF2S5_20845	COG1028	Short-chain dehydrogenase reductase Sdr
AVF2S5_20845	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AVF2S5_20970	COG0640	Transcriptional regulator
AVF2S5_20975	COG0798	PFAM Bile acid sodium symporter
AVF2S5_20980	COG1393	Belongs to the ArsC family
AVF2S5_21005	COG0745	RESPONSE REGULATOR receiver
AVF2S5_21010	COG2205	protein histidine kinase activity
AVF2S5_21015	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
AVF2S5_21025	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
AVF2S5_21050	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AVF2S5_21055	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AVF2S5_21060	COG1522	sequence-specific DNA binding
AVF2S5_21075	COG2267	carboxylic ester hydrolase activity
AVF2S5_21085	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AVF2S5_21090	COG1012	belongs to the aldehyde dehydrogenase family
AVF2S5_21105	COG1177	transmembrane transport
AVF2S5_21110	COG3842	ATPase activity
AVF2S5_21115	COG1012	belongs to the aldehyde dehydrogenase family
AVF2S5_21125	COG4154	Belongs to the RbsD FucU family
AVF2S5_21135	COG1172	Belongs to the binding-protein-dependent transport system permease family
AVF2S5_21140	COG1172	Belongs to the binding-protein-dependent transport system permease family
AVF2S5_21145	COG1129	ABC transporter
AVF2S5_21165	COG2721	sulfolactate sulfo-lyase activity
AVF2S5_21175	COG1028	Short-chain dehydrogenase reductase Sdr
AVF2S5_21190	COG0745	RESPONSE REGULATOR receiver
AVF2S5_21225	COG0183	Belongs to the thiolase family
AVF2S5_21230	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
AVF2S5_21240	COG1414	Transcriptional regulator
AVF2S5_21255	COG0583	DNA-binding transcription factor activity
AVF2S5_21260	COG2267	carboxylic ester hydrolase activity
AVF2S5_21265	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AVF2S5_21270	COG3485	protocatechuate 3,4-dioxygenase
AVF2S5_21275	COG3485	protocatechuate 3,4-dioxygenase
AVF2S5_21280	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AVF2S5_21285	COG0604	alcohol dehydrogenase
AVF2S5_21290	COG1674	ftsk spoiiie
AVF2S5_21295	COG3842	ATPase activity
AVF2S5_21310	COG0668	transmembrane transport
AVF2S5_21325	COG5265	(ABC) transporter
AVF2S5_21330	COG2205	protein histidine kinase activity
AVF2S5_21335	COG0745	RESPONSE REGULATOR receiver
AVF2S5_21410	COG0582	viral genome integration into host DNA
AVF2S5_21420	COG3346	SURF1 family
AVF2S5_21425	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
AVF2S5_21430	COG1845	cytochrome c oxidase, subunit III
AVF2S5_21435	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AVF2S5_21445	COG1595	DNA-templated transcription, initiation
AVF2S5_21455	COG0670	Belongs to the BI1 family
AVF2S5_21470	COG2273	Hydrolase Family 16
AVF2S5_21470	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
AVF2S5_21475	COG1301	dicarboxylic acid transport
AVF2S5_21480	COG4191	Histidine kinase
AVF2S5_21485	COG2204	response regulator
AVF2S5_21490	COG1309	transcriptional regulator
AVF2S5_21510	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
AVF2S5_21515	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AVF2S5_21520	COG2188	Transcriptional regulator
AVF2S5_21535	COG0395	ABC-type sugar transport system, permease component
AVF2S5_21545	COG3842	ATPase activity
AVF2S5_21570	COG1737	Transcriptional regulator
AVF2S5_21570	COG0837	glucose binding
AVF2S5_21575	COG1028	Short-chain dehydrogenase reductase Sdr
AVF2S5_21590	COG2814	Major facilitator Superfamily
AVF2S5_21595	COG3142	Participates in the control of copper homeostasis
AVF2S5_21615	COG0642	Histidine kinase
AVF2S5_21635	COG4952	isomerase
AVF2S5_21640	COG1028	Short-chain dehydrogenase reductase Sdr
AVF2S5_21640	COG3347	Dehydrogenase
AVF2S5_21655	COG1129	ABC transporter
AVF2S5_21660	COG1172	Belongs to the binding-protein-dependent transport system permease family
AVF2S5_21665	COG1172	Belongs to the binding-protein-dependent transport system permease family
AVF2S5_21670	COG3254	rhamnose metabolic process
AVF2S5_21680	COG0179	Fumarylacetoacetate (FAA) hydrolase
AVF2S5_21700	COG1176	ABC-type spermidine putrescine transport system, permease component I
AVF2S5_21710	COG3842	ATPase activity
AVF2S5_21730	COG2094	Belongs to the DNA glycosylase MPG family
AVF2S5_21735	COG4181	ATPase activity
AVF2S5_21740	COG0577	efflux transmembrane transporter activity
AVF2S5_21750	COG4303	Ethanolamine ammonia lyase large subunit
AVF2S5_21760	COG1192	Involved in chromosome partitioning
AVF2S5_21765	COG1475	DNA binding
AVF2S5_21770	COG0640	Transcriptional regulator
AVF2S5_21775	COG2072	flavoprotein involved in K transport
AVF2S5_21780	COG3706	GGDEF domain
AVF2S5_21815	COG2188	Transcriptional regulator
AVF2S5_21825	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AVF2S5_21850	COG2986	histidine ammonia-lyase
AVF2S5_21860	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AVF2S5_21880	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AVF2S5_21885	COG0601	transmembrane transport
AVF2S5_21905	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
AVF2S5_21920	COG4608	Belongs to the ABC transporter superfamily
AVF2S5_21925	COG0444	Belongs to the ABC transporter superfamily
AVF2S5_21930	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AVF2S5_21935	COG0601	transmembrane transport
AVF2S5_21945	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
AVF2S5_21975	COG0084	hydrolase, TatD family'
AVF2S5_21980	COG1079	Belongs to the binding-protein-dependent transport system permease family
AVF2S5_21985	COG4603	Belongs to the binding-protein-dependent transport system permease family
AVF2S5_21990	COG3845	ABC transporter
AVF2S5_22000	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AVF2S5_22005	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
AVF2S5_22020	COG3842	ATPase activity
AVF2S5_22025	COG1177	transmembrane transport
AVF2S5_22030	COG1176	ABC-type spermidine putrescine transport system, permease component I
AVF2S5_22060	COG1475	DNA binding
AVF2S5_22065	COG0019	diaminopimelate decarboxylase activity
AVF2S5_22070	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AVF2S5_22075	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
AVF2S5_22080	COG4264	IucA IucC family
AVF2S5_22085	COG2814	Major facilitator Superfamily
AVF2S5_22120	COG2186	Transcriptional regulator
AVF2S5_22130	COG0765	amino acid transport
AVF2S5_22145	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
AVF2S5_22155	COG1177	transmembrane transport
AVF2S5_22165	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AVF2S5_22175	COG1309	transcriptional regulator
AVF2S5_22190	COG0395	ABC-type sugar transport system, permease component
AVF2S5_22215	COG0243	molybdopterin cofactor binding
AVF2S5_22230	COG2826	transposase and inactivated derivatives, IS30 family
AVF2S5_22265	COG2205	protein histidine kinase activity
AVF2S5_22270	COG0745	RESPONSE REGULATOR receiver
AVF2S5_22310	COG1735	metal-dependent hydrolase with the TIM-barrel fold
AVF2S5_22315	COG1172	Belongs to the binding-protein-dependent transport system permease family
AVF2S5_22330	COG1609	Transcriptional regulator
AVF2S5_22345	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
AVF2S5_22350	COG0243	molybdopterin cofactor binding
AVF2S5_22355	COG2207	Transcriptional regulator
AVF2S5_22355	COG0662	Cupin 2, conserved barrel domain protein
AVF2S5_22410	COG5001	Diguanylate cyclase
AVF2S5_22410	COG4251	negative regulation of phosphorylation
AVF2S5_22410	COG3706	GGDEF domain
AVF2S5_22410	COG2203	Gaf domain
AVF2S5_22415	COG0583	DNA-binding transcription factor activity
AVF2S5_22420	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
AVF2S5_22460	COG1335	isochorismatase
AVF2S5_22465	COG2309	aminopeptidase activity
AVF2S5_22470	COG0596	Alpha beta hydrolase
AVF2S5_22475	COG3473	Maleate cis-trans isomerase
AVF2S5_22490	COG2080	2 iron, 2 sulfur cluster binding
AVF2S5_22495	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AVF2S5_22495	COG2010	Cytochrome c
AVF2S5_22500	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AVF2S5_22515	COG2223	nitrite transmembrane transporter activity
AVF2S5_22530	COG3842	ATPase activity
AVF2S5_22540	COG0395	ABC-type sugar transport system, permease component
AVF2S5_22545	COG1175	transmembrane transport
AVF2S5_22550	COG1653	transport
AVF2S5_22555	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AVF2S5_22555	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AVF2S5_22570	COG4770	biotin carboxylase activity
AVF2S5_22585	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AVF2S5_22610	COG1960	acyl-CoA dehydrogenase activity
AVF2S5_22615	COG0183	Belongs to the thiolase family
AVF2S5_22625	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AVF2S5_22690	COG1917	Cupin 2, conserved barrel domain protein
AVF2S5_22690	COG4977	sequence-specific DNA binding
AVF2S5_22745	COG2814	Major facilitator Superfamily
AVF2S5_22750	COG0583	DNA-binding transcription factor activity
AVF2S5_22765	COG4977	sequence-specific DNA binding
AVF2S5_22855	COG2963	transposase activity
AVF2S5_22875	COG3284	Transcriptional regulator
AVF2S5_22880	COG1063	alcohol dehydrogenase
AVF2S5_22910	COG2181	nitrate reductase activity
AVF2S5_22910	COG0247	lactate metabolic process
AVF2S5_22915	COG0277	FAD linked oxidase domain protein
AVF2S5_22950	COG2124	cytochrome p450
AVF2S5_22965	COG0318	PFAM AMP-dependent synthetase and ligase
AVF2S5_22975	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AVF2S5_22980	COG1024	Enoyl-CoA hydratase
AVF2S5_23000	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
AVF2S5_23020	COG1573	uracil-dna glycosylase
AVF2S5_23050	COG1802	Transcriptional regulator
AVF2S5_23055	COG2186	Transcriptional regulator
AVF2S5_23060	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AVF2S5_23065	COG1012	belongs to the aldehyde dehydrogenase family
AVF2S5_23070	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AVF2S5_23080	COG3448	diguanylate cyclase activity
AVF2S5_23080	COG4175	Glycine betaine
AVF2S5_23085	COG4176	ABC-type proline glycine betaine transport system permease component
AVF2S5_23090	COG4176	ABC-type proline glycine betaine transport system permease component
AVF2S5_23095	COG3938	Belongs to the proline racemase family
AVF2S5_23115	COG4644	lycopene metabolic process
AVF2S5_23135	COG1069	ribulokinase activity
AVF2S5_23140	COG3177	Filamentation induced by cAMP protein fic
AVF2S5_23155	COG1737	Transcriptional regulator
AVF2S5_23160	COG1172	Belongs to the binding-protein-dependent transport system permease family
AVF2S5_23165	COG1129	ABC transporter
AVF2S5_23180	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AVF2S5_23190	COG0395	ABC-type sugar transport system, permease component
AVF2S5_23195	COG1175	transmembrane transport
AVF2S5_23205	COG3842	ATPase activity
AVF2S5_23220	COG2186	Transcriptional regulator
AVF2S5_23235	COG1175	transmembrane transport
AVF2S5_23240	COG0395	ABC-type sugar transport system, permease component
AVF2S5_23250	COG3842	ATPase activity
AVF2S5_23270	COG0110	maltose O-acetyltransferase activity
AVF2S5_23285	COG1175	transmembrane transport
AVF2S5_23290	COG0395	ABC-type sugar transport system, permease component
AVF2S5_23300	COG1940	carbohydrate kinase activity
AVF2S5_23315	COG4172	Belongs to the ABC transporter superfamily
AVF2S5_23320	COG0747	negative chemotaxis
AVF2S5_23330	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AVF2S5_23335	COG2362	D-Aminopeptidase
AVF2S5_23340	COG1446	asparaginase
AVF2S5_23355	COG0840	transmembrane signaling receptor activity
AVF2S5_23365	COG3547	Transposase (IS116 IS110 IS902 family)
AVF2S5_23380	COG4372	Transposase
AVF2S5_23390	COG2963	transposase activity
AVF2S5_23400	COG1959	2 iron, 2 sulfur cluster binding
AVF2S5_23405	COG0534	Mate efflux family protein
AVF2S5_23425	COG0318	PFAM AMP-dependent synthetase and ligase
AVF2S5_23435	COG2226	methyltransferase
AVF2S5_23485	COG1629	transport
AVF2S5_23485	COG4774	siderophore transport
AVF2S5_23490	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
AVF2S5_23495	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AVF2S5_23500	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AVF2S5_23505	COG1120	ATPase activity
AVF2S5_23580	COG0601	transmembrane transport
AVF2S5_23585	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AVF2S5_23590	COG4608	Belongs to the ABC transporter superfamily
AVF2S5_23595	COG1349	DNA-binding transcription factor activity
AVF2S5_23600	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AVF2S5_23615	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
AVF2S5_23625	COG1802	Transcriptional regulator
AVF2S5_23635	COG0765	amino acid transport
AVF2S5_23640	COG0765	amino acid transport
AVF2S5_23665	COG1192	Involved in chromosome partitioning
AVF2S5_23670	COG1475	DNA binding
AVF2S5_23675	COG0640	Transcriptional regulator
AVF2S5_23695	COG3335	DDE superfamily endonuclease
AVF2S5_23700	COG3415	Transposase
AVF2S5_23715	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
AVF2S5_23745	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AVF2S5_23750	COG2814	Major facilitator Superfamily
AVF2S5_23760	COG0235	Class ii aldolase
AVF2S5_23795	COG1396	sequence-specific DNA binding
AVF2S5_23845	COG4297	protein containing double-stranded beta helix domain
AVF2S5_23935	COG1522	sequence-specific DNA binding
AVF2S5_23985	COG4191	Histidine kinase
AVF2S5_23985	COG0784	Response regulator, receiver
AVF2S5_24020	COG4191	Histidine kinase
AVF2S5_24020	COG0784	Response regulator, receiver
AVF2S5_24080	COG0840	transmembrane signaling receptor activity
AVF2S5_24090	COG4251	negative regulation of phosphorylation
AVF2S5_24100	COG3344	reverse transcriptase
AVF2S5_24105	COG2972	Histidine kinase
AVF2S5_24105	COG0840	transmembrane signaling receptor activity
AVF2S5_24120	COG5002	protein histidine kinase activity
AVF2S5_24130	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
AVF2S5_24135	COG2205	protein histidine kinase activity
AVF2S5_24135	COG3850	Histidine kinase
AVF2S5_24135	COG4999	Histidine kinase
AVF2S5_24135	COG3437	response regulator, receiver
AVF2S5_24160	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AVF2S5_24185	COG1396	sequence-specific DNA binding
AVF2S5_24190	COG3621	Patatin-like phospholipase
AVF2S5_24235	COG3265	gluconokinase activity
AVF2S5_24240	COG1028	Short-chain dehydrogenase reductase Sdr
AVF2S5_24245	COG1129	ABC transporter
AVF2S5_24250	COG1172	Belongs to the binding-protein-dependent transport system permease family
AVF2S5_24270	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AVF2S5_24275	COG1609	Transcriptional regulator
AVF2S5_24300	COG2195	Cleaves the N-terminal amino acid of tripeptides
AVF2S5_24305	COG2843	Capsule synthesis protein
AVF2S5_24315	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AVF2S5_24320	COG0601	transmembrane transport
AVF2S5_24325	COG4166	transmembrane transport
AVF2S5_24340	COG3609	addiction module antidote protein, CC2985 family
AVF2S5_24350	COG4584	PFAM Integrase catalytic
AVF2S5_24355	COG1484	DNA-dependent DNA replication
AVF2S5_24370	COG3177	Filamentation induced by cAMP protein fic
AVF2S5_24480	COG3831	ATPase activity
AVF2S5_24485	COG0776	regulation of translation
AVF2S5_24490	COG5489	Protein of unknown function (DUF736)
AVF2S5_24500	COG0300	oxidoreductase activity
AVF2S5_24515	COG1475	DNA binding
AVF2S5_24620	COG3701	Conjugal transfer protein
AVF2S5_24625	COG3846	protein secretion by the type IV secretion system
AVF2S5_24635	COG5314	conjugation
AVF2S5_24640	COG3451	type IV secretory pathway VirB4
AVF2S5_24655	COG4962	Type ii secretion system protein e
AVF2S5_24665	COG1192	Involved in chromosome partitioning
AVF2S5_24670	COG1475	DNA binding
AVF2S5_24675	COG0640	Transcriptional regulator
AVF2S5_24680	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
AVF2S5_24685	COG3177	Filamentation induced by cAMP protein fic
AVF2S5_24700	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
AVF2S5_24755	COG0583	DNA-binding transcription factor activity
AVF2S5_24840	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AVF2S5_24855	COG1132	(ABC) transporter
AVF2S5_24860	COG4172	Belongs to the ABC transporter superfamily
AVF2S5_24865	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AVF2S5_24875	COG0747	negative chemotaxis
AVF2S5_24885	COG1082	Xylose isomerase domain protein TIM barrel
AVF2S5_24955	COG1475	DNA binding
AVF2S5_24995	COG3742	Toxic component of a toxin-antitoxin (TA) module. An RNase
AVF2S5_25000	COG5489	Protein of unknown function (DUF736)
AVF2S5_25075	COG4172	Belongs to the ABC transporter superfamily
AVF2S5_25080	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AVF2S5_25100	COG2072	flavoprotein involved in K transport
AVF2S5_25105	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AVF2S5_25175	COG0584	glycerophosphoryl diester phosphodiesterase
AVF2S5_25185	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AVF2S5_25200	COG0444	Belongs to the ABC transporter superfamily
AVF2S5_25215	COG0747	negative chemotaxis
AVF2S5_25235	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AVF2S5_25240	COG0601	transmembrane transport
AVF2S5_25255	COG0444	Belongs to the ABC transporter superfamily
AVF2S5_25260	COG0747	negative chemotaxis
AVF2S5_25270	COG2390	Transcriptional regulator
AVF2S5_25285	COG4172	Belongs to the ABC transporter superfamily
AVF2S5_25290	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AVF2S5_25295	COG0601	transmembrane transport
AVF2S5_25315	COG0010	Belongs to the arginase family
AVF2S5_25375	COG1283	sodium-dependent phosphate transmembrane transporter activity
AVF2S5_25380	COG0483	inositol monophosphate 1-phosphatase activity
AVF2S5_25385	COG0584	glycerophosphoryl diester phosphodiesterase
AVF2S5_25395	COG1176	ABC-type spermidine putrescine transport system, permease component I
AVF2S5_25400	COG1175	transmembrane transport
AVF2S5_25405	COG3842	ATPase activity
AVF2S5_25425	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
AVF2S5_25435	COG1228	amidohydrolase
AVF2S5_25445	COG1177	transmembrane transport
AVF2S5_25455	COG3842	ATPase activity
AVF2S5_25480	COG2986	histidine ammonia-lyase
AVF2S5_25505	COG0765	amino acid transport
AVF2S5_25520	COG2079	MmgE PrpD family protein
AVF2S5_25525	COG0583	DNA-binding transcription factor activity
AVF2S5_25545	COG3701	Conjugal transfer protein
AVF2S5_25550	COG3846	protein secretion by the type IV secretion system
AVF2S5_25560	COG5314	conjugation
AVF2S5_25565	COG3451	type IV secretory pathway VirB4
AVF2S5_25580	COG4962	Type ii secretion system protein e
AVF2S5_25595	COG1475	DNA binding
AVF2S5_25600	COG0640	Transcriptional regulator
AVF2S5_25610	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
AVF2S5_25665	COG1196	nuclear chromosome segregation
AVF2S5_25670	COG2175	clavaminate synthase activity
AVF2S5_25710	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AVF2S5_25725	COG0587	DNA-directed DNA polymerase activity
AVF2S5_25760	COG1475	DNA binding
AVF2S5_25800	COG5489	Protein of unknown function (DUF736)
AVF2S5_25905	COG0483	inositol monophosphate 1-phosphatase activity
AVF2S5_25910	COG0584	glycerophosphoryl diester phosphodiesterase
AVF2S5_25920	COG1177	transmembrane transport
AVF2S5_25930	COG3842	ATPase activity
AVF2S5_25935	COG1940	carbohydrate kinase activity
AVF2S5_25955	COG3842	ATPase activity
AVF2S5_25960	COG4149	molybdate abc transporter
AVF2S5_25965	COG1177	transmembrane transport
AVF2S5_25975	COG1176	ABC-type spermidine putrescine transport system, permease component I
AVF2S5_25980	COG1177	transmembrane transport
AVF2S5_25985	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
AVF2S5_25990	COG3842	ATPase activity
AVF2S5_26000	COG0747	negative chemotaxis
AVF2S5_26010	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AVF2S5_26030	COG1176	ABC-type spermidine putrescine transport system, permease component I
AVF2S5_26040	COG1840	ABC-type Fe3 transport system, periplasmic component
AVF2S5_26065	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AVF2S5_26070	COG4172	Belongs to the ABC transporter superfamily
AVF2S5_26080	COG1064	alcohol dehydrogenase
AVF2S5_26110	COG4149	molybdate abc transporter
AVF2S5_26115	COG1177	transmembrane transport
AVF2S5_26120	COG3842	ATPase activity
AVF2S5_26125	COG1840	ABC-type Fe3 transport system, periplasmic component
AVF2S5_26135	COG4172	Belongs to the ABC transporter superfamily
AVF2S5_26140	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AVF2S5_26145	COG0601	transmembrane transport
AVF2S5_26150	COG4166	transmembrane transport
AVF2S5_26205	COG3701	Conjugal transfer protein
AVF2S5_26210	COG3846	protein secretion by the type IV secretion system
AVF2S5_26220	COG5314	conjugation
AVF2S5_26225	COG3451	type IV secretory pathway VirB4
AVF2S5_26240	COG4962	Type ii secretion system protein e
AVF2S5_26255	COG1475	DNA binding
AVF2S5_26260	COG0640	Transcriptional regulator
AVF2S5_26270	COG1192	Involved in chromosome partitioning
AVF2S5_26275	COG1475	DNA binding
AVF2S5_26280	COG0640	Transcriptional regulator
AVF2S5_26285	COG4691	Plasmid stability protein
AVF2S5_26290	COG1487	ribonuclease activity
AVF2S5_26325	COG1136	(ABC) transporter
AVF2S5_26335	COG1917	Cupin 2, conserved barrel domain protein
AVF2S5_26335	COG2207	Transcriptional regulator
AVF2S5_26365	COG2423	ornithine cyclodeaminase activity
AVF2S5_26375	COG4608	Belongs to the ABC transporter superfamily
AVF2S5_26390	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AVF2S5_26395	COG0747	negative chemotaxis
AVF2S5_26435	COG0154	amidase activity
AVF2S5_26445	COG1172	Belongs to the binding-protein-dependent transport system permease family
AVF2S5_26485	COG0583	DNA-binding transcription factor activity
AVF2S5_26495	COG1858	cytochrome C peroxidase
AVF2S5_26520	COG1192	Involved in chromosome partitioning
AVF2S5_26575	COG3842	ATPase activity
AVF2S5_26580	COG3842	ATPase activity
AVF2S5_26590	COG0395	ABC-type sugar transport system, permease component
AVF2S5_26595	COG1175	transmembrane transport
AVF2S5_26605	COG1609	Transcriptional regulator
AVF2S5_26665	COG0739	heme binding
AVF2S5_26665	COG0741	lytic transglycosylase activity
AVF2S5_26665	COG1196	nuclear chromosome segregation
AVF2S5_26685	COG3831	ATPase activity
AVF2S5_26725	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
AVF2S5_26740	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
AVF2S5_26780	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD