locus-tag	class	description
RvVAR0630_00010	COG0071	Belongs to the small heat shock protein (HSP20) family
RvVAR0630_00030	COG0220	tRNA (guanine-N7-)-methyltransferase activity
RvVAR0630_00040	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
RvVAR0630_00050	COG1396	sequence-specific DNA binding
RvVAR0630_00060	COG0815	Transfers the fatty acyl group on membrane lipoproteins
RvVAR0630_00070	COG4535	Mg2 and Co2 transporter CorC
RvVAR0630_00080	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
RvVAR0630_00090	COG1702	phosphate starvation-inducible protein PhoH
RvVAR0630_00100	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
RvVAR0630_00140	COG1214	PFAM Peptidase M22, glycoprotease
RvVAR0630_00150	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
RvVAR0630_00170	COG0180	Tryptophanyl-tRNA synthetase
RvVAR0630_00180	COG0346	lactoylglutathione lyase activity
RvVAR0630_00200	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
RvVAR0630_00210	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
RvVAR0630_00220	COG0583	DNA-binding transcription factor activity
RvVAR0630_00250	COG2205	protein histidine kinase activity
RvVAR0630_00250	COG3437	response regulator, receiver
RvVAR0630_00250	COG4999	Histidine kinase
RvVAR0630_00250	COG3850	Histidine kinase
RvVAR0630_00260	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
RvVAR0630_00270	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
RvVAR0630_00280	COG0116	Belongs to the methyltransferase superfamily
RvVAR0630_00280	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
RvVAR0630_00300	COG0776	regulation of translation
RvVAR0630_00320	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
RvVAR0630_00330	COG1137	ATPase activity
RvVAR0630_00350	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
RvVAR0630_00360	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
RvVAR0630_00370	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
RvVAR0630_00380	COG1420	regulation of RNA biosynthetic process
RvVAR0630_00390	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
RvVAR0630_00410	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
RvVAR0630_00420	COG0635	Involved in the biosynthesis of porphyrin-containing compound
RvVAR0630_00430	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
RvVAR0630_00440	COG0697	spore germination
RvVAR0630_00450	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
RvVAR0630_00460	COG0268	Binds directly to 16S ribosomal RNA
RvVAR0630_00470	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
RvVAR0630_00480	COG2226	methyltransferase
RvVAR0630_00490	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
RvVAR0630_00500	COG2198	Histidine kinase
RvVAR0630_00500	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RvVAR0630_00500	COG0784	Response regulator, receiver
RvVAR0630_00500	COG2205	protein histidine kinase activity
RvVAR0630_00510	COG0784	Response regulator, receiver
RvVAR0630_00520	COG3920	Histidine kinase
RvVAR0630_00530	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
RvVAR0630_00560	COG0583	DNA-binding transcription factor activity
RvVAR0630_00580	COG1741	Belongs to the pirin family
RvVAR0630_00620	COG1877	trehalose-phosphatase activity
RvVAR0630_00630	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
RvVAR0630_00640	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
RvVAR0630_00650	COG0756	dUTP diphosphatase activity
RvVAR0630_00660	COG1280	lysine exporter protein (LysE YggA)
RvVAR0630_00690	COG0606	chelatase, subunit chli
RvVAR0630_00700	COG0189	ligase activity
RvVAR0630_00720	COG3842	ATPase activity
RvVAR0630_00730	COG0395	ABC-type sugar transport system, permease component
RvVAR0630_00740	COG1175	transmembrane transport
RvVAR0630_00750	COG1653	transport
RvVAR0630_00760	COG0792	nuclease activity
RvVAR0630_00770	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
RvVAR0630_00790	COG3963	phosphatidate phosphatase activity
RvVAR0630_00810	COG0284	orotidine-5'-phosphate decarboxylase activity
RvVAR0630_00850	COG1968	undecaprenyl-diphosphatase activity
RvVAR0630_00870	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
RvVAR0630_00900	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
RvVAR0630_00910	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
RvVAR0630_00910	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
RvVAR0630_00990	COG0518	GMP synthase (glutamine-hydrolyzing) activity
RvVAR0630_00990	COG0519	Catalyzes the synthesis of GMP from XMP
RvVAR0630_01050	COG3002	Belongs to the UPF0753 family
RvVAR0630_01060	COG5001	Diguanylate cyclase
RvVAR0630_01060	COG3300	MHYT domain
RvVAR0630_01070	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
RvVAR0630_01090	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
RvVAR0630_01120	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
RvVAR0630_01130	COG2900	Belongs to the SlyX family
RvVAR0630_01140	COG0484	heat shock protein binding
RvVAR0630_01160	COG0443	Heat shock 70 kDa protein
RvVAR0630_01170	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
RvVAR0630_01190	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
RvVAR0630_01200	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
RvVAR0630_01220	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
RvVAR0630_01220	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
RvVAR0630_01230	COG0791	NLP P60 protein
RvVAR0630_01250	COG2353	YceI-like domain
RvVAR0630_01260	COG2353	YceI-like domain
RvVAR0630_01270	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
RvVAR0630_01310	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
RvVAR0630_01320	COG3454	Phosphonate metabolism
RvVAR0630_01330	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
RvVAR0630_01340	COG3639	organic phosphonate transmembrane transporter activity
RvVAR0630_01360	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
RvVAR0630_01370	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
RvVAR0630_01390	COG4778	phosphonate C-P lyase system protein PhnL
RvVAR0630_01400	COG4107	phosphonate C-P lyase system protein PhnK
RvVAR0630_01410	COG3627	carbon phosphorus lyase activity
RvVAR0630_01420	COG3626	phosphonate metabolism
RvVAR0630_01430	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
RvVAR0630_01440	COG3624	Phosphonate C-P lyase system protein PhnG
RvVAR0630_01450	COG2188	Transcriptional regulator
RvVAR0630_01460	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
RvVAR0630_01470	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
RvVAR0630_01560	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
RvVAR0630_01590	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
RvVAR0630_01600	COG4172	Belongs to the ABC transporter superfamily
RvVAR0630_01610	COG4239	(ABC) transporter, permease
RvVAR0630_01620	COG4174	ABC transporter (Permease)
RvVAR0630_01630	COG4166	transmembrane transport
RvVAR0630_01640	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
RvVAR0630_01650	COG1803	Methylglyoxal synthase
RvVAR0630_01660	COG0837	glucose binding
RvVAR0630_01670	COG1132	(ABC) transporter
RvVAR0630_01680	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
RvVAR0630_01690	COG0588	phosphoglycerate mutase activity
RvVAR0630_01710	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
RvVAR0630_01720	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
RvVAR0630_01730	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
RvVAR0630_01820	COG4964	Belongs to the GSP D family
RvVAR0630_01890	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
RvVAR0630_01890	COG0072	phenylalanine-tRNA ligase activity
RvVAR0630_01940	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
RvVAR0630_01950	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
RvVAR0630_01960	COG0291	Belongs to the bacterial ribosomal protein bL35 family
RvVAR0630_01970	COG2205	protein histidine kinase activity
RvVAR0630_01980	COG0745	RESPONSE REGULATOR receiver
RvVAR0630_02000	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
RvVAR0630_02040	COG0539	negative regulation of cytoplasmic translation
RvVAR0630_02050	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
RvVAR0630_02100	COG2860	membrane
RvVAR0630_02120	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
RvVAR0630_02140	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
RvVAR0630_02150	COG2813	Specifically methylates the guanine in position
RvVAR0630_02160	COG1185	polyribonucleotide nucleotidyltransferase activity
RvVAR0630_02180	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
RvVAR0630_02190	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
RvVAR0630_02200	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
RvVAR0630_02210	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
RvVAR0630_02230	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
RvVAR0630_02230	COG0195	Participates in both transcription termination and antitermination
RvVAR0630_02240	COG0779	Required for maturation of 30S ribosomal subunits
RvVAR0630_02250	COG2814	Major facilitator Superfamily
RvVAR0630_02300	COG2951	lytic endotransglycosylase activity
RvVAR0630_02310	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
RvVAR0630_02350	COG0667	Aldo Keto reductase
RvVAR0630_02440	COG1570	exodeoxyribonuclease VII activity
RvVAR0630_02450	COG1278	Cold shock
RvVAR0630_02480	COG2309	aminopeptidase activity
RvVAR0630_02500	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
RvVAR0630_02510	COG1393	Belongs to the ArsC family
RvVAR0630_02560	COG1607	acyl-coa hydrolase
RvVAR0630_02570	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
RvVAR0630_02610	COG0481	GTPase activity
RvVAR0630_02620	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
RvVAR0630_02650	COG3422	double-strand break repair
RvVAR0630_02670	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
RvVAR0630_02680	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
RvVAR0630_02700	COG2816	NAD+ diphosphatase activity
RvVAR0630_02720	COG1605	Chorismate mutase
RvVAR0630_02720	COG0077	Prephenate dehydratase
RvVAR0630_02730	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
RvVAR0630_02740	COG3474	cytochrome
RvVAR0630_02770	COG0395	ABC-type sugar transport system, permease component
RvVAR0630_02790	COG3842	ATPase activity
RvVAR0630_02800	COG3842	ATPase activity
RvVAR0630_02840	COG3806	Anti-sigma factor
RvVAR0630_02850	COG1595	DNA-templated transcription, initiation
RvVAR0630_02880	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
RvVAR0630_02890	COG4221	oxidoreductase activity
RvVAR0630_02930	COG3718	enzyme involved in inositol metabolism
RvVAR0630_02970	COG3962	Belongs to the TPP enzyme family
RvVAR0630_02980	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
RvVAR0630_03000	COG0673	inositol 2-dehydrogenase activity
RvVAR0630_03020	COG1609	Transcriptional regulator
RvVAR0630_03030	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
RvVAR0630_03040	COG2814	Major facilitator Superfamily
RvVAR0630_03070	COG2801	Transposase and inactivated derivatives
RvVAR0630_03110	COG2423	ornithine cyclodeaminase activity
RvVAR0630_03120	COG1643	Atp-dependent helicase
RvVAR0630_03140	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
RvVAR0630_03170	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
RvVAR0630_03180	COG1074	ATP-dependent DNA helicase activity
RvVAR0630_03190	COG2887	Belongs to the helicase family. UvrD subfamily
RvVAR0630_03200	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
RvVAR0630_03210	COG3178	'Phosphotransferase
RvVAR0630_03230	COG2205	protein histidine kinase activity
RvVAR0630_03240	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
RvVAR0630_03250	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
RvVAR0630_03260	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
RvVAR0630_03260	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
RvVAR0630_03270	COG0642	Histidine kinase
RvVAR0630_03280	COG0745	RESPONSE REGULATOR receiver
RvVAR0630_03290	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
RvVAR0630_03320	COG1072	(Pantothenic acid kinase))
RvVAR0630_03330	COG0140	phosphoribosyl-ATP diphosphatase activity
RvVAR0630_03340	COG0107	imidazoleglycerol-phosphate synthase activity
RvVAR0630_03350	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
RvVAR0630_03360	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
RvVAR0630_03370	COG0131	Imidazoleglycerol-phosphate dehydratase
RvVAR0630_03380	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
RvVAR0630_03390	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
RvVAR0630_03440	COG0285	dihydrofolate synthase activity
RvVAR0630_03450	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
RvVAR0630_03460	COG0159	tryptophan synthase activity
RvVAR0630_03470	COG0133	tryptophan synthase activity
RvVAR0630_03480	COG0135	phosphoribosylanthranilate isomerase activity
RvVAR0630_03560	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
RvVAR0630_03590	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
RvVAR0630_03610	COG0237	dephospho-CoA kinase activity
RvVAR0630_03620	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
RvVAR0630_03630	COG0424	maF-like protein
RvVAR0630_03640	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
RvVAR0630_03650	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
RvVAR0630_03670	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
RvVAR0630_03680	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
RvVAR0630_03690	COG0445	tRNA wobble uridine modification
RvVAR0630_03700	COG0357	Ribosomal RNA small subunit methyltransferase G
RvVAR0630_03750	COG0495	leucyl-tRNA aminoacylation
RvVAR0630_03760	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
RvVAR0630_03780	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
RvVAR0630_03800	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
RvVAR0630_03830	COG1473	amidohydrolase
RvVAR0630_03840	COG3459	Glycosyltransferase 36 associated
RvVAR0630_03870	COG2902	Dehydrogenase
RvVAR0630_03880	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
RvVAR0630_03890	COG0288	reversible hydration of carbon dioxide
RvVAR0630_03900	COG2010	Cytochrome c
RvVAR0630_03920	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
RvVAR0630_03940	COG0671	phosphoesterase, PA-phosphatase related
RvVAR0630_03950	COG0473	3-isopropylmalate dehydrogenase activity
RvVAR0630_03960	COG0066	3-isopropylmalate dehydratase activity
RvVAR0630_04020	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
RvVAR0630_04090	COG0183	Belongs to the thiolase family
RvVAR0630_04100	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
RvVAR0630_04110	COG0333	Belongs to the bacterial ribosomal protein bL32 family
RvVAR0630_04140	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
RvVAR0630_04150	COG0142	geranyltranstransferase activity
RvVAR0630_04170	COG2885	chlorophyll binding
RvVAR0630_04180	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
RvVAR0630_04190	COG0738	Major facilitator superfamily
RvVAR0630_04220	COG4221	oxidoreductase activity
RvVAR0630_04250	COG1522	sequence-specific DNA binding
RvVAR0630_04300	COG0745	RESPONSE REGULATOR receiver
RvVAR0630_04310	COG2198	Histidine kinase
RvVAR0630_04310	COG0643	Histidine kinase
RvVAR0630_04320	COG0835	chemotaxis
RvVAR0630_04330	COG0840	transmembrane signaling receptor activity
RvVAR0630_04340	COG3290	protein histidine kinase activity
RvVAR0630_04340	COG0840	transmembrane signaling receptor activity
RvVAR0630_04350	COG0840	transmembrane signaling receptor activity
RvVAR0630_04360	COG0835	chemotaxis
RvVAR0630_04370	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
RvVAR0630_04380	COG2201	protein-glutamate methylesterase activity
RvVAR0630_04430	COG1192	Involved in chromosome partitioning
RvVAR0630_04440	COG0494	nUDIX hydrolase
RvVAR0630_04460	COG0793	Belongs to the peptidase S41A family
RvVAR0630_04500	COG0501	Belongs to the peptidase M48B family
RvVAR0630_04510	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
RvVAR0630_04510	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
RvVAR0630_04530	COG0138	bifunctional purine biosynthesis protein purh
RvVAR0630_04560	COG0261	This protein binds to 23S rRNA in the presence of protein L20
RvVAR0630_04570	COG0211	Belongs to the bacterial ribosomal protein bL27 family
RvVAR0630_04610	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
RvVAR0630_04620	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
RvVAR0630_04630	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
RvVAR0630_04640	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
RvVAR0630_04650	COG0799	negative regulation of ribosome biogenesis
RvVAR0630_04660	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
RvVAR0630_04720	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
RvVAR0630_04800	COG0828	Belongs to the bacterial ribosomal protein bS21 family
RvVAR0630_04820	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
RvVAR0630_04830	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
RvVAR0630_04860	COG2017	converts alpha-aldose to the beta-anomer
RvVAR0630_04890	COG3118	belongs to the thioredoxin family
RvVAR0630_04900	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
RvVAR0630_04910	COG2835	tetraacyldisaccharide 4'-kinase activity
RvVAR0630_04920	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
RvVAR0630_04930	COG1946	Acyl-CoA thioesterase
RvVAR0630_04940	COG0347	Belongs to the P(II) protein family
RvVAR0630_04950	COG0004	ammonium transporteR
RvVAR0630_04960	COG1674	ftsk spoiiie
RvVAR0630_04970	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
RvVAR0630_05010	COG0745	RESPONSE REGULATOR receiver
RvVAR0630_05040	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
RvVAR0630_05080	COG0765	amino acid transport
RvVAR0630_05100	COG2372	response to copper ion
RvVAR0630_05100	COG1276	copper resistance
RvVAR0630_05110	COG2372	response to copper ion
RvVAR0630_05140	COG0335	large ribosomal subunit rRNA binding
RvVAR0630_05170	COG0336	Belongs to the RNA methyltransferase TrmD family
RvVAR0630_05180	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
RvVAR0630_05190	COG0228	four-way junction DNA binding
RvVAR0630_05200	COG0287	Prephenate dehydrogenase
RvVAR0630_05200	COG1605	Chorismate mutase
RvVAR0630_05210	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
RvVAR0630_05240	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
RvVAR0630_05250	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
RvVAR0630_05260	COG0552	protein localization to endoplasmic reticulum
RvVAR0630_05270	COG2917	probably involved in intracellular septation
RvVAR0630_05310	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
RvVAR0630_05320	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
RvVAR0630_05330	COG4133	protoheme IX ABC transporter activity
RvVAR0630_05340	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
RvVAR0630_05380	COG0670	Belongs to the BI1 family
RvVAR0630_05390	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
RvVAR0630_05400	COG1136	(ABC) transporter
RvVAR0630_05420	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
RvVAR0630_05430	COG2154	pterin-4-alpha-carbinolamine dehydratase
RvVAR0630_05460	COG0820	rRNA (adenine-C2-)-methyltransferase activity
RvVAR0630_05480	COG1280	lysine exporter protein (LysE YggA)
RvVAR0630_05500	COG1028	Short-chain dehydrogenase reductase Sdr
RvVAR0630_05520	COG0137	argininosuccinate synthase activity
RvVAR0630_05560	COG0339	signal peptide processing
RvVAR0630_05600	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
RvVAR0630_05610	COG1872	DUF167
RvVAR0630_05690	COG0181	hydroxymethylbilane synthase activity
RvVAR0630_05700	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
RvVAR0630_05710	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
RvVAR0630_05720	COG2350	Protein conserved in bacteria
RvVAR0630_05740	COG2264	protein methyltransferase activity
RvVAR0630_05810	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
RvVAR0630_05820	COG0039	L-malate dehydrogenase activity
RvVAR0630_05830	COG0045	succinate-CoA ligase (ADP-forming) activity
RvVAR0630_05850	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
RvVAR0630_05870	COG0508	dehydrogenase complex catalyzes the overall conversion of
RvVAR0630_05920	COG4974	Belongs to the 'phage' integrase family
RvVAR0630_05930	COG0840	transmembrane signaling receptor activity
RvVAR0630_05960	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
RvVAR0630_05970	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
RvVAR0630_05980	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
RvVAR0630_05990	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
RvVAR0630_06000	COG0355	proton-transporting ATP synthase activity, rotational mechanism
RvVAR0630_06010	COG0039	L-malate dehydrogenase activity
RvVAR0630_06020	COG0640	Transcriptional regulator
RvVAR0630_06060	COG3383	formate dehydrogenase (NAD+) activity
RvVAR0630_06070	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
RvVAR0630_06090	COG2223	nitrite transmembrane transporter activity
RvVAR0630_06100	COG0835	chemotaxis
RvVAR0630_06130	COG0729	surface antigen
RvVAR0630_06150	COG0156	8-amino-7-oxononanoate synthase activity
RvVAR0630_06170	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
RvVAR0630_06200	COG0840	transmembrane signaling receptor activity
RvVAR0630_06220	COG0745	RESPONSE REGULATOR receiver
RvVAR0630_06230	COG2198	Histidine kinase
RvVAR0630_06230	COG0643	Histidine kinase
RvVAR0630_06240	COG0835	chemotaxis
RvVAR0630_06250	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
RvVAR0630_06260	COG2201	protein-glutamate methylesterase activity
RvVAR0630_06270	COG0745	RESPONSE REGULATOR receiver
RvVAR0630_06280	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
RvVAR0630_06300	COG1766	The M ring may be actively involved in energy transduction
RvVAR0630_06310	COG2771	luxR family
RvVAR0630_06330	COG0628	permease
RvVAR0630_06340	COG1473	amidohydrolase
RvVAR0630_06350	COG1686	Belongs to the peptidase S11 family
RvVAR0630_06360	COG0523	cobalamin synthesis protein
RvVAR0630_06380	COG3034	peptidoglycan biosynthetic process
RvVAR0630_06390	COG0825	malonyl-CoA metabolic process
RvVAR0630_06400	COG4974	Belongs to the 'phage' integrase family
RvVAR0630_06420	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
RvVAR0630_06430	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
RvVAR0630_06490	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
RvVAR0630_06500	COG0227	Belongs to the bacterial ribosomal protein bL28 family
RvVAR0630_06550	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
RvVAR0630_06560	COG2226	methyltransferase
RvVAR0630_06570	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
RvVAR0630_06580	COG0287	Prephenate dehydrogenase
RvVAR0630_06600	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
RvVAR0630_06640	COG2884	Cell division ATP-binding protein ftsE
RvVAR0630_06710	COG0165	Argininosuccinate lyase
RvVAR0630_06720	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
RvVAR0630_06730	COG0625	glutathione transferase activity
RvVAR0630_06740	COG1250	3-hydroxyacyl-CoA dehydrogenase
RvVAR0630_06750	COG2972	Histidine kinase
RvVAR0630_06750	COG0840	transmembrane signaling receptor activity
RvVAR0630_06770	COG2086	electron transfer activity
RvVAR0630_06800	COG0300	oxidoreductase activity
RvVAR0630_06820	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
RvVAR0630_06910	COG0667	Aldo Keto reductase
RvVAR0630_06930	COG3293	Transposase
RvVAR0630_06970	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
RvVAR0630_07000	COG0653	protein targeting
RvVAR0630_07010	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
RvVAR0630_07020	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
RvVAR0630_07040	COG0494	nUDIX hydrolase
RvVAR0630_07070	COG2226	methyltransferase
RvVAR0630_07090	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
RvVAR0630_07100	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
RvVAR0630_07130	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
RvVAR0630_07180	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
RvVAR0630_07180	COG0392	lysyltransferase activity
RvVAR0630_07190	COG0527	aspartate kinase activity
RvVAR0630_07220	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
RvVAR0630_07230	COG2890	protein-(glutamine-N5) methyltransferase activity
RvVAR0630_07250	COG0542	response to heat
RvVAR0630_07290	COG0469	pyruvate kinase activity
RvVAR0630_07300	COG0489	protein tyrosine kinase activity
RvVAR0630_07300	COG3206	protein involved in exopolysaccharide biosynthesis
RvVAR0630_07320	COG1215	transferase activity, transferring glycosyl groups
RvVAR0630_07330	COG1215	transferase activity, transferring glycosyl groups
RvVAR0630_07340	COG1215	transferase activity, transferring glycosyl groups
RvVAR0630_07350	COG0438	transferase activity, transferring glycosyl groups
RvVAR0630_07360	COG2273	Hydrolase Family 16
RvVAR0630_07370	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
RvVAR0630_07380	COG2244	polysaccharide biosynthetic process
RvVAR0630_07390	COG0463	Glycosyl transferase, family 2
RvVAR0630_07400	COG2327	Polysaccharide pyruvyl transferase
RvVAR0630_07410	COG1215	transferase activity, transferring glycosyl groups
RvVAR0630_07440	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
RvVAR0630_07450	COG1596	polysaccharide export
RvVAR0630_07460	COG3307	-O-antigen
RvVAR0630_07500	COG0400	carboxylic ester hydrolase activity
RvVAR0630_07510	COG0346	lactoylglutathione lyase activity
RvVAR0630_07560	COG1289	transmembrane transporter activity
RvVAR0630_07600	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
RvVAR0630_07620	COG2986	histidine ammonia-lyase
RvVAR0630_07630	COG1228	amidohydrolase
RvVAR0630_07640	COG0402	S-adenosylhomocysteine deaminase activity
RvVAR0630_07670	COG4598	ABC transporter
RvVAR0630_07680	COG0765	amino acid transport
RvVAR0630_07690	COG0765	amino acid transport
RvVAR0630_07710	COG1072	(Pantothenic acid kinase))
RvVAR0630_07750	COG1940	carbohydrate kinase activity
RvVAR0630_07790	COG0010	Belongs to the arginase family
RvVAR0630_07820	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
RvVAR0630_07840	COG0848	biopolymer transport protein
RvVAR0630_07870	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
RvVAR0630_07950	COG0784	Response regulator, receiver
RvVAR0630_07970	COG0783	Belongs to the Dps family
RvVAR0630_08010	COG1793	dna ligase
RvVAR0630_08030	COG0789	Transcriptional regulator
RvVAR0630_08050	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
RvVAR0630_08070	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
RvVAR0630_08100	COG0438	transferase activity, transferring glycosyl groups
RvVAR0630_08160	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
RvVAR0630_08180	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
RvVAR0630_08200	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
RvVAR0630_08210	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
RvVAR0630_08230	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
RvVAR0630_08240	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
RvVAR0630_08260	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
RvVAR0630_08310	COG3415	Transposase
RvVAR0630_08320	COG3335	DDE superfamily endonuclease
RvVAR0630_08330	COG0840	transmembrane signaling receptor activity
RvVAR0630_08340	COG0419	ATPase involved in DNA repair
RvVAR0630_08400	COG0438	transferase activity, transferring glycosyl groups
RvVAR0630_08450	COG0601	transmembrane transport
RvVAR0630_08460	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RvVAR0630_08480	COG0438	transferase activity, transferring glycosyl groups
RvVAR0630_08490	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
RvVAR0630_08500	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
RvVAR0630_08510	COG0840	transmembrane signaling receptor activity
RvVAR0630_08510	COG2972	Histidine kinase
RvVAR0630_08520	COG4953	penicillin-binding protein 1C
RvVAR0630_08530	COG2373	Large extracellular alpha-helical protein
RvVAR0630_08540	COG2807	transmembrane transport
RvVAR0630_08550	COG2186	Transcriptional regulator
RvVAR0630_08560	COG0697	spore germination
RvVAR0630_08570	COG2832	Protein of unknown function (DUF454)
RvVAR0630_08580	COG0800	Aldolase
RvVAR0630_08590	COG3734	2-keto-3-deoxy-galactonokinase
RvVAR0630_08620	COG0129	dihydroxy-acid dehydratase activity
RvVAR0630_08640	COG4214	carbohydrate transport
RvVAR0630_08660	COG4213	ABC transporter substrate-binding protein
RvVAR0630_08700	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
RvVAR0630_08710	COG2721	sulfolactate sulfo-lyase activity
RvVAR0630_08720	COG1312	Catalyzes the dehydration of D-mannonate
RvVAR0630_08730	COG0246	Mannitol dehydrogenase
RvVAR0630_08740	COG1028	Short-chain dehydrogenase reductase Sdr
RvVAR0630_08760	COG1917	Cupin 2, conserved barrel domain protein
RvVAR0630_08770	COG1904	glucuronate isomerase
RvVAR0630_08780	COG1802	Transcriptional regulator
RvVAR0630_08790	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
RvVAR0630_08810	COG0747	negative chemotaxis
RvVAR0630_08820	COG0601	transmembrane transport
RvVAR0630_08840	COG0444	Belongs to the ABC transporter superfamily
RvVAR0630_08860	COG3454	Phosphonate metabolism
RvVAR0630_08880	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
RvVAR0630_08890	COG1129	ABC transporter
RvVAR0630_08890	COG0842	Transport permease protein
RvVAR0630_08900	COG0842	Transport permease protein
RvVAR0630_08910	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RvVAR0630_08920	COG0601	transmembrane transport
RvVAR0630_08950	COG1473	amidohydrolase
RvVAR0630_08960	COG4172	Belongs to the ABC transporter superfamily
RvVAR0630_09030	COG2274	protein secretion by the type I secretion system
RvVAR0630_09060	COG3273	potassium ion transport
RvVAR0630_09060	COG0471	metal ion transport
RvVAR0630_09070	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
RvVAR0630_09080	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
RvVAR0630_09120	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
RvVAR0630_09150	COG3335	DDE superfamily endonuclease
RvVAR0630_09160	COG3415	Transposase
RvVAR0630_09200	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
RvVAR0630_09240	COG1253	flavin adenine dinucleotide binding
RvVAR0630_09250	COG1309	transcriptional regulator
RvVAR0630_09280	COG1609	Transcriptional regulator
RvVAR0630_09290	COG1070	Carbohydrate kinase
RvVAR0630_09300	COG2115	Belongs to the xylose isomerase family
RvVAR0630_09320	COG0673	inositol 2-dehydrogenase activity
RvVAR0630_09360	COG2202	Pas domain
RvVAR0630_09360	COG2200	EAL domain
RvVAR0630_09360	COG2199	diguanylate cyclase activity
RvVAR0630_09390	COG2378	regulation of single-species biofilm formation
RvVAR0630_09410	COG2954	triphosphatase activity
RvVAR0630_09480	COG0583	DNA-binding transcription factor activity
RvVAR0630_09530	COG3047	cAMP biosynthetic process
RvVAR0630_09540	COG0840	transmembrane signaling receptor activity
RvVAR0630_09560	COG0523	cobalamin synthesis protein
RvVAR0630_09580	COG1846	Transcriptional regulator
RvVAR0630_09590	COG1609	Transcriptional regulator
RvVAR0630_09600	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
RvVAR0630_09610	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
RvVAR0630_09620	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
RvVAR0630_09660	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
RvVAR0630_09680	COG1733	regulation of RNA biosynthetic process
RvVAR0630_09710	COG0446	pyridine nucleotide-disulphide oxidoreductase
RvVAR0630_09710	COG0404	The glycine cleavage system catalyzes the degradation of glycine
RvVAR0630_09730	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
RvVAR0630_09740	COG0828	Belongs to the bacterial ribosomal protein bS21 family
RvVAR0630_09810	COG1523	belongs to the glycosyl hydrolase 13 family
RvVAR0630_09820	COG0033	Phosphoglucomutase
RvVAR0630_09830	COG0297	glycogen (starch) synthase activity
RvVAR0630_09840	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
RvVAR0630_09850	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
RvVAR0630_09860	COG0058	SHG alpha-glucan phosphorylase activity
RvVAR0630_09900	COG2307	Protein conserved in bacteria
RvVAR0630_09900	COG2308	Evidence 4 Homologs of previously reported genes of
RvVAR0630_09930	COG0662	Cupin 2, conserved barrel domain protein
RvVAR0630_09930	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
RvVAR0630_09950	COG0419	ATPase involved in DNA repair
RvVAR0630_10010	COG0071	Belongs to the small heat shock protein (HSP20) family
RvVAR0630_10030	COG0067	glutamate synthase
RvVAR0630_10030	COG0069	glutamate synthase activity
RvVAR0630_10030	COG0070	glutamate synthase
RvVAR0630_10050	COG0840	transmembrane signaling receptor activity
RvVAR0630_10070	COG2951	lytic endotransglycosylase activity
RvVAR0630_10080	COG1210	Utp--glucose-1-phosphate uridylyltransferase
RvVAR0630_10100	COG0517	IMP dehydrogenase activity
RvVAR0630_10100	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
RvVAR0630_10120	COG0330	HflC and HflK could
RvVAR0630_10130	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
RvVAR0630_10140	COG0720	synthase
RvVAR0630_10150	COG0602	queuosine metabolic process
RvVAR0630_10160	COG0840	transmembrane signaling receptor activity
RvVAR0630_10180	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
RvVAR0630_10190	COG0737	Belongs to the 5'-nucleotidase family
RvVAR0630_10220	COG5310	Homospermidine synthase
RvVAR0630_10240	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
RvVAR0630_10250	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
RvVAR0630_10250	COG0512	Glutamine amidotransferase of anthranilate synthase
RvVAR0630_10290	COG0679	Auxin Efflux Carrier
RvVAR0630_10300	COG0583	DNA-binding transcription factor activity
RvVAR0630_10310	COG3750	Belongs to the UPF0335 family
RvVAR0630_10350	COG0469	pyruvate kinase activity
RvVAR0630_10360	COG0596	Alpha beta hydrolase
RvVAR0630_10370	COG0457	Tetratricopeptide repeat
RvVAR0630_10380	COG0257	Belongs to the bacterial ribosomal protein bL36 family
RvVAR0630_10390	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
RvVAR0630_10400	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
RvVAR0630_10430	COG0640	Transcriptional regulator
RvVAR0630_10450	COG0352	thiamine-phosphate diphosphorylase activity
RvVAR0630_10470	COG0483	inositol monophosphate 1-phosphatase activity
RvVAR0630_10510	COG1132	(ABC) transporter
RvVAR0630_10520	COG0254	rRNA binding
RvVAR0630_10650	COG0384	phenazine biosynthesis protein PhzF
RvVAR0630_10660	COG3588	fructose-bisphosphate aldolase
RvVAR0630_10670	COG0126	phosphoglycerate kinase activity
RvVAR0630_10680	COG1692	metallophosphoesterase
RvVAR0630_10690	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
RvVAR0630_10700	COG0840	transmembrane signaling receptor activity
RvVAR0630_10820	COG0217	transcriptional regulatory protein
RvVAR0630_10830	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
RvVAR0630_10840	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
RvVAR0630_10850	COG0037	tRNA processing
RvVAR0630_10870	COG2885	chlorophyll binding
RvVAR0630_10880	COG0823	Involved in the tonB-independent uptake of proteins
RvVAR0630_10920	COG0824	Thioesterase
RvVAR0630_10950	COG0494	nUDIX hydrolase
RvVAR0630_10960	COG1408	metallophosphoesterase
RvVAR0630_10970	COG2255	four-way junction helicase activity
RvVAR0630_10990	COG2002	toxin-antitoxin pair type II binding
RvVAR0630_11000	COG0632	four-way junction helicase activity
RvVAR0630_11010	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
RvVAR0630_11020	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
RvVAR0630_11070	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
RvVAR0630_11080	COG0840	transmembrane signaling receptor activity
RvVAR0630_11090	COG1271	oxidase subunit
RvVAR0630_11100	COG1294	oxidase, subunit
RvVAR0630_11160	COG4774	siderophore transport
RvVAR0630_11180	COG1120	ATPase activity
RvVAR0630_11220	COG4774	siderophore transport
RvVAR0630_11230	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
RvVAR0630_11240	COG1122	ATPase activity
RvVAR0630_11510	COG3293	Transposase
RvVAR0630_11540	COG5005	Phage virion morphogenesis
RvVAR0630_11650	COG4396	Host-nuclease inhibitor protein Gam
RvVAR0630_11760	COG0482	sulfurtransferase activity
RvVAR0630_11780	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
RvVAR0630_11830	COG1175	transmembrane transport
RvVAR0630_11910	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
RvVAR0630_12000	COG0402	S-adenosylhomocysteine deaminase activity
RvVAR0630_12020	COG1116	anion transmembrane transporter activity
RvVAR0630_12060	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
RvVAR0630_12080	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
RvVAR0630_12110	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
RvVAR0630_12140	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
RvVAR0630_12150	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
RvVAR0630_12150	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
RvVAR0630_12160	COG0564	pseudouridine synthase activity
RvVAR0630_12180	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
RvVAR0630_12300	COG1218	3'(2'),5'-bisphosphate nucleotidase
RvVAR0630_12320	COG2814	Major facilitator Superfamily
RvVAR0630_12400	COG0850	regulation of cytokinetic process
RvVAR0630_12410	COG2894	cell division
RvVAR0630_12420	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
RvVAR0630_12520	COG0784	Response regulator, receiver
RvVAR0630_12520	COG2205	protein histidine kinase activity
RvVAR0630_12540	COG4251	negative regulation of phosphorylation
RvVAR0630_12630	COG0829	nickel cation binding
RvVAR0630_12640	COG0831	urea catabolic process
RvVAR0630_12650	COG3813	Protein conserved in bacteria
RvVAR0630_12660	COG0832	Belongs to the urease beta subunit family
RvVAR0630_12670	COG3755	Protein conserved in bacteria
RvVAR0630_12680	COG1442	glycosyl transferase family 8
RvVAR0630_12690	COG0804	urea catabolic process
RvVAR0630_12730	COG5001	Diguanylate cyclase
RvVAR0630_12730	COG5002	protein histidine kinase activity
RvVAR0630_12740	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
RvVAR0630_12750	COG0830	nickel cation binding
RvVAR0630_12760	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
RvVAR0630_12810	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
RvVAR0630_12820	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
RvVAR0630_12830	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
RvVAR0630_12890	COG1309	transcriptional regulator
RvVAR0630_12930	COG0493	'glutamate synthase
RvVAR0630_12970	COG2346	COG2346, Truncated hemoglobins
RvVAR0630_13000	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
RvVAR0630_13020	COG2308	Evidence 4 Homologs of previously reported genes of
RvVAR0630_13230	COG0250	Participates in transcription elongation, termination and antitermination
RvVAR0630_13270	COG3209	COG3209 Rhs family protein
RvVAR0630_13310	COG3501	Rhs element vgr protein
RvVAR0630_13400	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
RvVAR0630_13460	COG1982	Orn Lys Arg decarboxylase major
RvVAR0630_13490	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
RvVAR0630_13520	COG1733	regulation of RNA biosynthetic process
RvVAR0630_13550	COG0513	Belongs to the DEAD box helicase family
RvVAR0630_13580	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
RvVAR0630_13580	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
RvVAR0630_13590	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
RvVAR0630_13620	COG3706	GGDEF domain
RvVAR0630_13650	COG1064	alcohol dehydrogenase
RvVAR0630_13660	COG3195	allantoin biosynthetic process
RvVAR0630_13660	COG3648	Uricase
RvVAR0630_13690	COG0174	glutamine synthetase
RvVAR0630_13700	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
RvVAR0630_13710	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
RvVAR0630_13720	COG2351	hydroxyisourate hydrolase activity
RvVAR0630_13790	COG0137	argininosuccinate synthase activity
RvVAR0630_13800	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
RvVAR0630_13820	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
RvVAR0630_13830	COG0402	S-adenosylhomocysteine deaminase activity
RvVAR0630_13850	COG0583	DNA-binding transcription factor activity
RvVAR0630_13870	COG0457	Tetratricopeptide repeat
RvVAR0630_13890	COG1529	Aldehyde oxidase and xanthine dehydrogenase
RvVAR0630_13910	COG1028	Short-chain dehydrogenase reductase Sdr
RvVAR0630_13920	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
RvVAR0630_13930	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
RvVAR0630_13940	COG0024	Methionine aminopeptidase
RvVAR0630_13970	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
RvVAR0630_14010	COG1160	GTP binding
RvVAR0630_14030	COG0366	Alpha amylase catalytic
RvVAR0630_14040	COG4115	mRNA cleavage
RvVAR0630_14060	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
RvVAR0630_14160	COG4175	Glycine betaine
RvVAR0630_14190	COG1435	thymidine kinase activity
RvVAR0630_14220	COG2197	response regulator
RvVAR0630_14230	COG2759	Belongs to the formate--tetrahydrofolate ligase family
RvVAR0630_14260	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
RvVAR0630_14300	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
RvVAR0630_14310	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
RvVAR0630_14330	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
RvVAR0630_14330	COG0512	Glutamine amidotransferase of anthranilate synthase
RvVAR0630_14380	COG3501	Rhs element vgr protein
RvVAR0630_14440	COG4115	mRNA cleavage
RvVAR0630_14460	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
RvVAR0630_14470	COG3135	benzoate transporter
RvVAR0630_14500	COG0740	serine-type endopeptidase activity
RvVAR0630_14530	COG0435	Glutathione S-transferase
RvVAR0630_14570	COG0454	-acetyltransferase
RvVAR0630_14610	COG0714	Associated with various cellular activities
RvVAR0630_14640	COG0617	tRNA 3'-terminal CCA addition
RvVAR0630_14670	COG0408	coproporphyrinogen oxidase activity
RvVAR0630_14690	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
RvVAR0630_14710	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
RvVAR0630_14720	COG1132	(ABC) transporter
RvVAR0630_14740	COG1132	(ABC) transporter
RvVAR0630_14790	COG2857	Cytochrome c1
RvVAR0630_14790	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
RvVAR0630_14800	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
RvVAR0630_14830	COG0386	Belongs to the glutathione peroxidase family
RvVAR0630_14870	COG0012	GTP binding
RvVAR0630_14880	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
RvVAR0630_14910	COG0193	aminoacyl-tRNA hydrolase activity
RvVAR0630_14940	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
RvVAR0630_14960	COG1012	belongs to the aldehyde dehydrogenase family
RvVAR0630_14990	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
RvVAR0630_15020	COG0006	proline dipeptidase activity
RvVAR0630_15050	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
RvVAR0630_15090	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
RvVAR0630_15100	COG2205	protein histidine kinase activity
RvVAR0630_15110	COG0745	RESPONSE REGULATOR receiver
RvVAR0630_15120	COG1846	Transcriptional regulator
RvVAR0630_15140	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
RvVAR0630_15150	COG1278	Cold shock
RvVAR0630_15180	COG0436	Aminotransferase
RvVAR0630_15200	COG0387	Pfam Sodium calcium exchanger
RvVAR0630_15240	COG1902	pentaerythritol trinitrate reductase activity
RvVAR0630_15250	COG0640	Transcriptional regulator
RvVAR0630_15260	COG0583	DNA-binding transcription factor activity
RvVAR0630_15270	COG0492	ferredoxin-NADP+ reductase activity
RvVAR0630_15280	COG1522	sequence-specific DNA binding
RvVAR0630_15350	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
RvVAR0630_15370	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
RvVAR0630_15410	COG2321	neutral zinc metallopeptidase
RvVAR0630_15420	COG0667	Aldo Keto reductase
RvVAR0630_15430	COG0583	DNA-binding transcription factor activity
RvVAR0630_15440	COG0534	Mate efflux family protein
RvVAR0630_15450	COG0505	Belongs to the CarA family
RvVAR0630_15500	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
RvVAR0630_15540	COG1473	amidohydrolase
RvVAR0630_15570	COG0583	DNA-binding transcription factor activity
RvVAR0630_15590	COG3706	GGDEF domain
RvVAR0630_15590	COG4251	negative regulation of phosphorylation
RvVAR0630_15590	COG2203	Gaf domain
RvVAR0630_15590	COG5001	Diguanylate cyclase
RvVAR0630_15600	COG0432	Pfam Uncharacterised protein family UPF0047
RvVAR0630_15670	COG1278	Cold shock
RvVAR0630_15720	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
RvVAR0630_15790	COG1475	DNA binding
RvVAR0630_15990	COG4373	Mu-like prophage FluMu protein gp28
RvVAR0630_16260	COG2968	Membrane
RvVAR0630_16280	COG0697	spore germination
RvVAR0630_16290	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
RvVAR0630_16400	COG1396	sequence-specific DNA binding
RvVAR0630_16410	COG2197	response regulator
RvVAR0630_16420	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
RvVAR0630_16450	COG3842	ATPase activity
RvVAR0630_16470	COG0395	ABC-type sugar transport system, permease component
RvVAR0630_16520	COG1376	ErfK ybiS ycfS ynhG family protein
RvVAR0630_16550	COG0251	oxidation-reduction process
RvVAR0630_16560	COG0028	Belongs to the TPP enzyme family
RvVAR0630_16570	COG0697	spore germination
RvVAR0630_16580	COG2267	carboxylic ester hydrolase activity
RvVAR0630_16610	COG0840	transmembrane signaling receptor activity
RvVAR0630_16620	COG0840	transmembrane signaling receptor activity
RvVAR0630_16630	COG2226	methyltransferase
RvVAR0630_16760	COG3023	N-Acetylmuramoyl-L-alanine amidase
RvVAR0630_16790	COG2001	Belongs to the MraZ family
RvVAR0630_16800	COG0275	rRNA processing
RvVAR0630_16830	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
RvVAR0630_16850	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
RvVAR0630_16860	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
RvVAR0630_16880	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
RvVAR0630_16890	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
RvVAR0630_16900	COG0812	UDP-N-acetylmuramate dehydrogenase activity
RvVAR0630_16910	COG0477	Major facilitator Superfamily
RvVAR0630_16930	COG1181	Belongs to the D-alanine--D-alanine ligase family
RvVAR0630_16940	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
RvVAR0630_16950	COG0849	cell division
RvVAR0630_16960	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
RvVAR0630_16980	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
RvVAR0630_17000	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
RvVAR0630_17020	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
RvVAR0630_17090	COG0456	acetyltransferase
RvVAR0630_17100	COG0840	transmembrane signaling receptor activity
RvVAR0630_17120	COG2176	DNA-directed DNA polymerase activity
RvVAR0630_17150	COG0835	chemotaxis
RvVAR0630_17160	COG0840	transmembrane signaling receptor activity
RvVAR0630_17170	COG1999	signal sequence binding
RvVAR0630_17180	COG2264	protein methyltransferase activity
RvVAR0630_17250	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
RvVAR0630_17270	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
RvVAR0630_17280	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
RvVAR0630_17290	COG1335	isochorismatase
RvVAR0630_17300	COG4993	Dehydrogenase
RvVAR0630_17340	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
RvVAR0630_17350	COG0573	inorganic phosphate transmembrane transporter activity
RvVAR0630_17360	COG0581	inorganic phosphate transmembrane transporter activity
RvVAR0630_17370	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
RvVAR0630_17380	COG0277	FAD linked oxidase domain protein
RvVAR0630_17440	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
RvVAR0630_17450	COG2259	Doxx family
RvVAR0630_17480	COG0330	HflC and HflK could
RvVAR0630_17510	COG3830	Belongs to the UPF0237 family
RvVAR0630_17510	COG0560	Phosphoserine phosphatase
RvVAR0630_17520	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
RvVAR0630_17570	COG0028	Belongs to the TPP enzyme family
RvVAR0630_17600	COG0656	L-ascorbic acid biosynthetic process
RvVAR0630_17620	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
RvVAR0630_17630	COG0789	Transcriptional regulator
RvVAR0630_17640	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
RvVAR0630_17660	COG1733	regulation of RNA biosynthetic process
RvVAR0630_17680	COG2814	Major facilitator Superfamily
RvVAR0630_17690	COG1309	transcriptional regulator
RvVAR0630_17700	COG1794	racemase activity, acting on amino acids and derivatives
RvVAR0630_17710	COG1522	sequence-specific DNA binding
RvVAR0630_17740	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
RvVAR0630_17760	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
RvVAR0630_17810	COG0384	phenazine biosynthesis protein PhzF
RvVAR0630_18050	COG3750	Belongs to the UPF0335 family
RvVAR0630_18400	COG3335	DDE superfamily endonuclease
RvVAR0630_18410	COG3415	Transposase
RvVAR0630_18440	COG0405	Gamma-glutamyltransferase
RvVAR0630_18500	COG0318	PFAM AMP-dependent synthetase and ligase
RvVAR0630_18530	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
RvVAR0630_18540	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
RvVAR0630_18550	COG4558	Periplasmic binding protein
RvVAR0630_18580	COG3264	Mechanosensitive ion channel
RvVAR0630_18580	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
RvVAR0630_18590	COG2226	methyltransferase
RvVAR0630_18620	COG0745	RESPONSE REGULATOR receiver
RvVAR0630_18640	COG1131	(ABC) transporter
RvVAR0630_18650	COG0842	Transport permease protein
RvVAR0630_18760	COG4608	Belongs to the ABC transporter superfamily
RvVAR0630_18780	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RvVAR0630_18790	COG0584	glycerophosphoryl diester phosphodiesterase
RvVAR0630_18850	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
RvVAR0630_18880	COG0525	valine-tRNA ligase activity
RvVAR0630_18920	COG0316	Belongs to the HesB IscA family
RvVAR0630_18930	COG0232	Belongs to the dGTPase family. Type 2 subfamily
RvVAR0630_18940	COG0018	arginyl-trna synthetase
RvVAR0630_18980	COG1472	Belongs to the glycosyl hydrolase 3 family
RvVAR0630_18990	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
RvVAR0630_19000	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
RvVAR0630_19010	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
RvVAR0630_19020	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
RvVAR0630_19030	COG0805	protein transport
RvVAR0630_19040	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
RvVAR0630_19050	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
RvVAR0630_19060	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
RvVAR0630_19090	COG1862	Preprotein translocase
RvVAR0630_19140	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
RvVAR0630_19260	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
RvVAR0630_19310	COG2875	Belongs to the precorrin methyltransferase family
RvVAR0630_19330	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
RvVAR0630_19340	COG2099	Precorrin-6x reductase
RvVAR0630_19350	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
RvVAR0630_19400	COG2239	Acts as a magnesium transporter
RvVAR0630_19450	COG1760	l-serine dehydratase
RvVAR0630_19470	COG0835	chemotaxis
RvVAR0630_19480	COG2972	Histidine kinase
RvVAR0630_19480	COG0840	transmembrane signaling receptor activity
RvVAR0630_19490	COG1058	Belongs to the CinA family
RvVAR0630_19490	COG1546	Belongs to the CinA family
RvVAR0630_19510	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
RvVAR0630_19530	COG0840	transmembrane signaling receptor activity
RvVAR0630_19540	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
RvVAR0630_19580	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
RvVAR0630_19640	COG0583	DNA-binding transcription factor activity
RvVAR0630_19690	COG3698	Phosphodiester glycosidase
RvVAR0630_19730	COG0517	IMP dehydrogenase activity
RvVAR0630_19730	COG4175	Glycine betaine
RvVAR0630_19740	COG4176	ABC-type proline glycine betaine transport system permease component
RvVAR0630_19760	COG1492	cobalamin metabolic process
RvVAR0630_19770	COG0671	phosphoesterase, PA-phosphatase related
RvVAR0630_19780	COG0303	'Molybdopterin
RvVAR0630_19790	COG0315	cyclic pyranopterin monophosphate synthase activity
RvVAR0630_19800	COG0134	indole-3-glycerol-phosphate synthase activity
RvVAR0630_19810	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
RvVAR0630_19830	COG0372	Belongs to the citrate synthase family
RvVAR0630_19840	COG2333	competence protein COMEC
RvVAR0630_19840	COG0658	competence protein
RvVAR0630_19850	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
RvVAR0630_19860	COG2313	pseudouridylate synthase activity
RvVAR0630_19880	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
RvVAR0630_19890	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
RvVAR0630_19910	COG1126	abc transporter atp-binding protein
RvVAR0630_19920	COG0765	amino acid transport
RvVAR0630_19930	COG4597	amino acid ABC transporter
RvVAR0630_19940	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RvVAR0630_19960	COG0626	cystathionine gamma-synthase activity
RvVAR0630_20000	COG2267	carboxylic ester hydrolase activity
RvVAR0630_20050	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
RvVAR0630_20090	COG0537	adenosine 5'-monophosphoramidase activity
RvVAR0630_20140	COG0052	Belongs to the universal ribosomal protein uS2 family
RvVAR0630_20160	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
RvVAR0630_20170	COG0528	UMP kinase activity
RvVAR0630_20180	COG0233	cytoplasmic translational termination
RvVAR0630_20190	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
RvVAR0630_20210	COG0750	zinc metalloprotease
RvVAR0630_20220	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
RvVAR0630_20230	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
RvVAR0630_20240	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
RvVAR0630_20250	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
RvVAR0630_20270	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
RvVAR0630_20280	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
RvVAR0630_20300	COG1671	Belongs to the UPF0178 family
RvVAR0630_20310	COG2153	protein acetylation
RvVAR0630_20320	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
RvVAR0630_20360	COG4770	biotin carboxylase activity
RvVAR0630_20380	COG3665	Urea carboxylase-associated protein
RvVAR0630_20390	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
RvVAR0630_20430	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
RvVAR0630_20450	COG0463	Glycosyl transferase, family 2
RvVAR0630_20470	COG0737	Belongs to the 5'-nucleotidase family
RvVAR0630_20490	COG0252	asparaginase activity
RvVAR0630_20520	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
RvVAR0630_20530	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
RvVAR0630_20580	COG0544	peptidyl-prolyl cis-trans isomerase activity
RvVAR0630_20590	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
RvVAR0630_20610	COG0436	Aminotransferase
RvVAR0630_20640	COG3768	UPF0283 membrane protein
RvVAR0630_20650	COG3106	COG3106 Predicted ATPase
RvVAR0630_20660	COG2062	phosphohistidine phosphatase, SixA
RvVAR0630_20720	COG2080	2 iron, 2 sulfur cluster binding
RvVAR0630_20730	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
RvVAR0630_20740	COG1529	Aldehyde oxidase and xanthine dehydrogenase
RvVAR0630_20750	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
RvVAR0630_20790	COG0343	queuine tRNA-ribosyltransferase activity
RvVAR0630_20800	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
RvVAR0630_20830	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
RvVAR0630_20860	COG2151	metal-sulfur cluster biosynthetic enzyme
RvVAR0630_20870	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
RvVAR0630_20880	COG0346	lactoylglutathione lyase activity
RvVAR0630_20900	COG0396	ATPase activity
RvVAR0630_20920	COG0719	Fe-S assembly protein
RvVAR0630_20930	COG1104	cysteine desulfurase activity
RvVAR0630_20940	COG2945	thiolester hydrolase activity
RvVAR0630_20950	COG1280	lysine exporter protein (LysE YggA)
RvVAR0630_20960	COG0513	Belongs to the DEAD box helicase family
RvVAR0630_21010	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
RvVAR0630_21060	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
RvVAR0630_21120	COG0129	dihydroxy-acid dehydratase activity
RvVAR0630_21130	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
RvVAR0630_21140	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
RvVAR0630_21170	COG3507	Belongs to the glycosyl hydrolase 43 family
RvVAR0630_21180	COG0667	Aldo Keto reductase
RvVAR0630_21220	COG3842	ATPase activity
RvVAR0630_21230	COG0395	ABC-type sugar transport system, permease component
RvVAR0630_21240	COG1175	transmembrane transport
RvVAR0630_21250	COG1653	transport
RvVAR0630_21280	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
RvVAR0630_21330	COG2217	Heavy metal translocating P-type atpase
RvVAR0630_21340	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
RvVAR0630_21350	COG2095	MarC family integral membrane protein
RvVAR0630_21370	COG0629	single-stranded DNA binding
RvVAR0630_21380	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
RvVAR0630_21410	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
RvVAR0630_21410	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
RvVAR0630_21420	COG0347	Belongs to the P(II) protein family
RvVAR0630_21430	COG0174	glutamine synthetase
RvVAR0630_21480	COG0697	spore germination
RvVAR0630_21500	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
RvVAR0630_21520	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
RvVAR0630_21570	COG1278	Cold shock
RvVAR0630_21580	COG0346	lactoylglutathione lyase activity
RvVAR0630_21600	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
RvVAR0630_21620	COG0436	Aminotransferase
RvVAR0630_21640	COG3243	poly(R)-hydroxyalkanoic acid synthase
RvVAR0630_21650	COG1489	DNA binding
RvVAR0630_21660	COG2855	membrane
RvVAR0630_21670	COG0583	DNA-binding transcription factor activity
RvVAR0630_21680	COG0024	Methionine aminopeptidase
RvVAR0630_21690	COG2003	Belongs to the UPF0758 family
RvVAR0630_21720	COG0477	Major facilitator Superfamily
RvVAR0630_21750	COG0546	phosphoglycolate phosphatase activity
RvVAR0630_21760	COG0564	pseudouridine synthase activity
RvVAR0630_21770	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
RvVAR0630_21810	COG0404	The glycine cleavage system catalyzes the degradation of glycine
RvVAR0630_21820	COG0509	glycine decarboxylation via glycine cleavage system
RvVAR0630_21830	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
RvVAR0630_21830	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
RvVAR0630_21900	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
RvVAR0630_21920	COG0633	Ferredoxin
RvVAR0630_22000	COG0504	CTP synthase activity
RvVAR0630_22020	COG0149	triose-phosphate isomerase activity
RvVAR0630_22050	COG0187	DNA topoisomerase II activity
RvVAR0630_22140	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
RvVAR0630_22150	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
RvVAR0630_22180	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
RvVAR0630_22190	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
RvVAR0630_22210	COG0302	gtp cyclohydrolase
RvVAR0630_22220	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
RvVAR0630_22230	COG1752	Esterase of the alpha-beta hydrolase superfamily
RvVAR0630_22300	COG1686	Belongs to the peptidase S11 family
RvVAR0630_22340	COG0735	belongs to the Fur family
RvVAR0630_22350	COG1108	ABC-type Mn2 Zn2 transport systems permease components
RvVAR0630_22360	COG1121	(ABC) transporter
RvVAR0630_22380	COG0523	cobalamin synthesis protein
RvVAR0630_22410	COG3842	ATPase activity
RvVAR0630_22420	COG4149	molybdate abc transporter
RvVAR0630_22430	COG1177	transmembrane transport
RvVAR0630_22470	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
RvVAR0630_22480	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
RvVAR0630_22540	COG1183	phosphatidylcholine synthase activity
RvVAR0630_22550	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
RvVAR0630_22560	COG0785	Cytochrome C biogenesis protein
RvVAR0630_22580	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
RvVAR0630_22580	COG0321	lipoyl(octanoyl) transferase activity
RvVAR0630_22590	COG0084	hydrolase, TatD family'
RvVAR0630_22600	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
RvVAR0630_22610	COG0730	response to heat
RvVAR0630_22630	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
RvVAR0630_22640	COG1686	Belongs to the peptidase S11 family
RvVAR0630_22660	COG1028	Short-chain dehydrogenase reductase Sdr
RvVAR0630_22710	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
RvVAR0630_22710	COG1648	precorrin-2 dehydrogenase activity
RvVAR0630_22730	COG3956	TIGRFAM MazG family protein
RvVAR0630_22750	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
RvVAR0630_22760	COG1923	regulation of RNA biosynthetic process
RvVAR0630_22770	COG2204	response regulator
RvVAR0630_22780	COG5000	phosphorelay sensor kinase activity
RvVAR0630_22790	COG2204	response regulator
RvVAR0630_22800	COG3852	Histidine kinase
RvVAR0630_22820	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
RvVAR0630_22820	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
RvVAR0630_22830	COG1546	Belongs to the CinA family
RvVAR0630_22830	COG1058	Belongs to the CinA family
RvVAR0630_22860	COG2867	negative regulation of translational initiation
RvVAR0630_22870	COG0477	Major facilitator Superfamily
RvVAR0630_22910	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
RvVAR0630_22930	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
RvVAR0630_22960	COG0508	dehydrogenase complex catalyzes the overall conversion of
RvVAR0630_22970	COG0508	dehydrogenase complex catalyzes the overall conversion of
RvVAR0630_22970	COG0022	dehydrogenase e1 component
RvVAR0630_22980	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
RvVAR0630_23000	COG0148	phosphopyruvate hydratase activity
RvVAR0630_23010	COG2877	3-deoxy-8-phosphooctulonate synthase activity
RvVAR0630_23030	COG3161	chorismate lyase activity
RvVAR0630_23070	COG0556	nucleotide-excision repair
RvVAR0630_23080	COG4251	negative regulation of phosphorylation
RvVAR0630_23080	COG3706	GGDEF domain
RvVAR0630_23080	COG2203	Gaf domain
RvVAR0630_23080	COG5001	Diguanylate cyclase
RvVAR0630_23150	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
RvVAR0630_23180	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
RvVAR0630_23190	COG0546	phosphoglycolate phosphatase activity
RvVAR0630_23200	COG2989	Protein conserved in bacteria
RvVAR0630_23210	COG0114	fumarate hydratase activity
RvVAR0630_23240	COG3706	GGDEF domain
RvVAR0630_23260	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
RvVAR0630_23280	COG0746	molybdenum cofactor guanylyltransferase activity
RvVAR0630_23290	COG1763	Mo-molybdopterin cofactor biosynthetic process
RvVAR0630_23350	COG5425	PFAM Usg family protein
RvVAR0630_23380	COG2084	Dehydrogenase
RvVAR0630_23390	COG1522	sequence-specific DNA binding
RvVAR0630_23400	COG1573	uracil-dna glycosylase
RvVAR0630_23420	COG2205	protein histidine kinase activity
RvVAR0630_23420	COG2202	Pas domain
RvVAR0630_23450	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
RvVAR0630_23460	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
RvVAR0630_23480	COG0778	Nitroreductase
RvVAR0630_23490	COG0823	Involved in the tonB-independent uptake of proteins
RvVAR0630_23540	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
RvVAR0630_23550	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
RvVAR0630_23560	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
RvVAR0630_23570	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
RvVAR0630_23580	COG0635	Involved in the biosynthesis of porphyrin-containing compound
RvVAR0630_23600	COG0242	peptide deformylase activity
RvVAR0630_23660	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
RvVAR0630_23670	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
RvVAR0630_23690	COG2963	transposase activity
RvVAR0630_23710	COG4372	Transposase
RvVAR0630_23760	COG0463	Glycosyl transferase, family 2
RvVAR0630_23760	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
RvVAR0630_24000	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
RvVAR0630_24160	COG0250	Participates in transcription elongation, termination and antitermination
RvVAR0630_24270	COG0321	lipoyl(octanoyl) transferase activity
RvVAR0630_24290	COG0484	heat shock protein binding
RvVAR0630_24300	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
RvVAR0630_24330	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
RvVAR0630_24340	COG2814	Major facilitator Superfamily
RvVAR0630_24350	COG0483	inositol monophosphate 1-phosphatase activity
RvVAR0630_24360	COG0483	inositol monophosphate 1-phosphatase activity
RvVAR0630_24370	COG0037	tRNA processing
RvVAR0630_24390	COG2066	Belongs to the glutaminase family
RvVAR0630_24400	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
RvVAR0630_24410	COG0861	Integral membrane protein TerC family
RvVAR0630_24440	COG2195	Cleaves the N-terminal amino acid of tripeptides
RvVAR0630_24450	COG0657	acetylesterase activity
RvVAR0630_24450	COG2755	lipolytic protein G-D-S-L family
RvVAR0630_24470	COG1253	flavin adenine dinucleotide binding
RvVAR0630_24490	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
RvVAR0630_24500	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
RvVAR0630_24510	COG0538	isocitrate dehydrogenase activity
RvVAR0630_24530	COG3706	GGDEF domain
RvVAR0630_24560	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
RvVAR0630_24570	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
RvVAR0630_24580	COG0047	phosphoribosylformylglycinamidine synthase activity
RvVAR0630_24620	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
RvVAR0630_24630	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
RvVAR0630_24630	COG3218	ABC-type transport auxiliary lipoprotein component
RvVAR0630_24650	COG1127	ABC transporter
RvVAR0630_24660	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
RvVAR0630_24680	COG0281	malic enzyme
RvVAR0630_24680	COG0280	phosphate acetyltransferase
RvVAR0630_24730	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
RvVAR0630_24740	COG2833	Protein of unknown function (DUF455)
RvVAR0630_24750	COG0739	heme binding
RvVAR0630_24770	COG0415	Belongs to the DNA photolyase family
RvVAR0630_24780	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
RvVAR0630_24790	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
RvVAR0630_24800	COG2897	thiosulfate sulfurtransferase activity
RvVAR0630_24830	COG0203	ribosomal protein L17
RvVAR0630_24840	COG0202	RNA polymerase activity
RvVAR0630_24850	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
RvVAR0630_24860	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
RvVAR0630_24870	COG0563	adenylate kinase activity
RvVAR0630_24880	COG0201	protein transport
RvVAR0630_24890	COG0200	Binds to the 23S rRNA
RvVAR0630_24900	COG1841	ribosomal large subunit assembly
RvVAR0630_24910	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
RvVAR0630_24920	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
RvVAR0630_24930	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
RvVAR0630_24940	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
RvVAR0630_24950	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
RvVAR0630_24960	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
RvVAR0630_24970	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
RvVAR0630_24980	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
RvVAR0630_24990	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
RvVAR0630_25000	COG0255	Belongs to the universal ribosomal protein uL29 family
RvVAR0630_25010	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
RvVAR0630_25020	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
RvVAR0630_25030	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
RvVAR0630_25040	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
RvVAR0630_25050	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
RvVAR0630_25060	COG0089	rRNA binding
RvVAR0630_25070	COG0088	Forms part of the polypeptide exit tunnel
RvVAR0630_25080	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
RvVAR0630_25090	COG0051	transcription antitermination factor activity, RNA binding
RvVAR0630_25100	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
RvVAR0630_25110	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
RvVAR0630_25120	COG0049	tRNA binding
RvVAR0630_25130	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
RvVAR0630_25160	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
RvVAR0630_25170	COG0085	RNA polymerase activity
RvVAR0630_25180	COG0222	ribosome binding
RvVAR0630_25190	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
RvVAR0630_25200	COG0081	regulation of translation
RvVAR0630_25210	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
RvVAR0630_25230	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
RvVAR0630_25270	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
RvVAR0630_25280	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
RvVAR0630_25310	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
RvVAR0630_25330	COG0284	orotidine-5'-phosphate decarboxylase activity
RvVAR0630_25350	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
RvVAR0630_25360	COG0860	N-Acetylmuramoyl-L-alanine amidase
RvVAR0630_25370	COG1530	ribonuclease E activity
RvVAR0630_25370	COG1530	ribonuclease E activity
RvVAR0630_25390	COG0436	Aminotransferase
RvVAR0630_25400	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
RvVAR0630_25410	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
RvVAR0630_25420	COG0511	ligase activity, forming carbon-carbon bonds
RvVAR0630_25440	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
RvVAR0630_25450	COG4765	Protein conserved in bacteria
RvVAR0630_25490	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
RvVAR0630_25500	COG0463	Glycosyl transferase, family 2
RvVAR0630_25510	COG3952	Lipid A Biosynthesis
RvVAR0630_25510	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
RvVAR0630_25520	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
RvVAR0630_25550	COG0154	amidase activity
RvVAR0630_25560	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
RvVAR0630_25570	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
RvVAR0630_25580	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
RvVAR0630_25630	COG1960	acyl-CoA dehydrogenase activity
RvVAR0630_25640	COG0540	Belongs to the ATCase OTCase family
RvVAR0630_25660	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
RvVAR0630_25670	COG0758	DNA mediated transformation
RvVAR0630_25690	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
RvVAR0630_25700	COG0557	exoribonuclease II activity
RvVAR0630_25720	COG0477	Major facilitator Superfamily
RvVAR0630_25730	COG0267	Belongs to the bacterial ribosomal protein bL33 family
RvVAR0630_25750	COG0784	Response regulator, receiver
RvVAR0630_25780	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
RvVAR0630_25810	COG1136	(ABC) transporter
RvVAR0630_25830	COG0442	prolyl-tRNA aminoacylation
RvVAR0630_25850	COG0251	oxidation-reduction process
RvVAR0630_25860	COG0346	lactoylglutathione lyase activity
RvVAR0630_25890	COG1007	ATP synthesis coupled electron transport
RvVAR0630_25920	COG0713	ATP synthesis coupled electron transport
RvVAR0630_25940	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
RvVAR0630_25950	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
RvVAR0630_25970	COG0052	Belongs to the universal ribosomal protein uS2 family
RvVAR0630_25980	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
RvVAR0630_25990	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
RvVAR0630_26010	COG0649	NAD binding
RvVAR0630_26020	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
RvVAR0630_26030	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
RvVAR0630_26040	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
RvVAR0630_26050	COG1024	Enoyl-CoA hydratase
RvVAR0630_26100	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
RvVAR0630_26110	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
RvVAR0630_26120	COG0740	serine-type endopeptidase activity
RvVAR0630_26140	COG2124	cytochrome p450
RvVAR0630_26160	COG1408	metallophosphoesterase
RvVAR0630_26180	COG1832	CoA-binding protein
RvVAR0630_26200	COG1832	CoA-binding protein
RvVAR0630_26210	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
RvVAR0630_26220	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
RvVAR0630_26230	COG2329	Antibiotic biosynthesis monooxygenase
RvVAR0630_26260	COG0010	Belongs to the arginase family
RvVAR0630_26270	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
RvVAR0630_26290	COG3384	dioxygenase
RvVAR0630_26300	COG1612	heme a metabolic process
RvVAR0630_26460	COG0776	regulation of translation
RvVAR0630_26470	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
RvVAR0630_26480	COG0416	fatty acid biosynthetic process
RvVAR0630_26520	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
RvVAR0630_26530	COG2814	Major facilitator Superfamily
RvVAR0630_26540	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
RvVAR0630_26550	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
RvVAR0630_26590	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
RvVAR0630_26590	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
RvVAR0630_26600	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
RvVAR0630_26610	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
RvVAR0630_26650	COG0113	porphobilinogen synthase activity
RvVAR0630_26670	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
RvVAR0630_26680	COG2203	Gaf domain
RvVAR0630_26680	COG2200	EAL domain
RvVAR0630_26680	COG2199	diguanylate cyclase activity
RvVAR0630_26700	COG3300	MHYT domain
RvVAR0630_26700	COG5001	Diguanylate cyclase
RvVAR0630_26710	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
RvVAR0630_26740	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
RvVAR0630_26770	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
RvVAR0630_26810	COG1914	H( )-stimulated, divalent metal cation uptake system
RvVAR0630_26820	COG1321	iron dependent repressor
RvVAR0630_26830	COG0248	Ppx GppA phosphatase
RvVAR0630_26840	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
RvVAR0630_26860	COG0628	permease
RvVAR0630_26870	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
RvVAR0630_26880	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
RvVAR0630_26890	COG0730	response to heat
RvVAR0630_26900	COG2391	methyltransferase activity
RvVAR0630_26920	COG0640	Transcriptional regulator
RvVAR0630_26930	COG3453	Protein conserved in bacteria
RvVAR0630_26930	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
RvVAR0630_26950	COG0243	molybdopterin cofactor binding
RvVAR0630_26960	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
RvVAR0630_26970	COG0625	glutathione transferase activity
RvVAR0630_26990	COG1028	Short-chain dehydrogenase reductase Sdr
RvVAR0630_27000	COG0322	excinuclease ABC activity
RvVAR0630_27010	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
RvVAR0630_27030	COG0314	molybdopterin synthase activity
RvVAR0630_27040	COG0105	UTP biosynthetic process
RvVAR0630_27100	COG0488	(ABC) transporter
RvVAR0630_27110	COG1505	serine-type exopeptidase activity
RvVAR0630_27140	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
RvVAR0630_27150	COG0671	phosphoesterase, PA-phosphatase related
RvVAR0630_27180	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
RvVAR0630_27200	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
RvVAR0630_27210	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
RvVAR0630_27220	COG0500	methyltransferase
RvVAR0630_27230	COG0194	GDP metabolic process
RvVAR0630_27240	COG1561	YicC-like family, N-terminal region
RvVAR0630_27250	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
RvVAR0630_27260	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
RvVAR0630_27270	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
RvVAR0630_27290	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
RvVAR0630_27300	COG0667	Aldo Keto reductase
RvVAR0630_27340	COG0360	Binds together with S18 to 16S ribosomal RNA
RvVAR0630_27350	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
RvVAR0630_27370	COG0359	binds to the 23S rRNA
RvVAR0630_27380	COG0305	Participates in initiation and elongation during chromosome replication
RvVAR0630_27410	COG0765	amino acid transport
RvVAR0630_27420	COG0765	amino acid transport
RvVAR0630_27430	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
RvVAR0630_27460	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
RvVAR0630_27470	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
RvVAR0630_27480	COG1286	toxin biosynthetic process
RvVAR0630_27490	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
RvVAR0630_27500	COG4221	oxidoreductase activity
RvVAR0630_27530	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
RvVAR0630_27540	COG1091	dTDP-4-dehydrorhamnose reductase activity
RvVAR0630_27550	COG1088	dTDP-glucose 4,6-dehydratase activity
RvVAR0630_27560	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
RvVAR0630_27570	COG5434	Belongs to the glycosyl hydrolase 28 family
RvVAR0630_27580	COG0215	cysteine-tRNA ligase activity
RvVAR0630_27660	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
RvVAR0630_27670	COG2962	Rard protein
RvVAR0630_27690	COG1652	LysM domain
RvVAR0630_27690	COG2823	Periplasmic or secreted lipoprotein
RvVAR0630_27700	COG5265	(ABC) transporter
RvVAR0630_27710	COG0688	phosphatidylethanolamine metabolic process
RvVAR0630_27720	COG1183	phosphatidylcholine synthase activity
RvVAR0630_27750	COG1051	belongs to the nudix hydrolase family
RvVAR0630_27800	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
RvVAR0630_27830	COG1418	mRNA catabolic process
RvVAR0630_27860	COG1381	Involved in DNA repair and RecF pathway recombination
RvVAR0630_27870	COG3180	Ammonia monooxygenase
RvVAR0630_27880	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
RvVAR0630_27890	COG0571	ribonuclease III activity
RvVAR0630_27900	COG0681	Belongs to the peptidase S26 family
RvVAR0630_27930	COG1758	RNA polymerase activity
RvVAR0630_27950	COG0840	transmembrane signaling receptor activity
RvVAR0630_27960	COG2169	Transcriptional regulator
RvVAR0630_27960	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
RvVAR0630_27980	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
RvVAR0630_27990	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
RvVAR0630_28010	COG0741	lytic transglycosylase activity
RvVAR0630_28080	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
RvVAR0630_28110	COG0625	glutathione transferase activity
RvVAR0630_28130	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
RvVAR0630_28150	COG0463	Glycosyl transferase, family 2
RvVAR0630_28160	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
RvVAR0630_28170	COG1695	Transcriptional regulator
RvVAR0630_28200	COG0174	glutamine synthetase
RvVAR0630_28210	COG4166	transmembrane transport
RvVAR0630_28220	COG0601	transmembrane transport
RvVAR0630_28230	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RvVAR0630_28240	COG4172	Belongs to the ABC transporter superfamily
RvVAR0630_28260	COG2814	Major facilitator Superfamily
RvVAR0630_28270	COG2239	Acts as a magnesium transporter
RvVAR0630_28280	COG3293	Transposase
RvVAR0630_28310	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
RvVAR0630_28320	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
RvVAR0630_28350	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
RvVAR0630_28380	COG0443	Heat shock 70 kDa protein
RvVAR0630_28450	COG3290	protein histidine kinase activity
RvVAR0630_28450	COG0840	transmembrane signaling receptor activity
RvVAR0630_28460	COG0308	aminopeptidase N
RvVAR0630_28470	COG2202	Pas domain
RvVAR0630_28470	COG2205	protein histidine kinase activity
RvVAR0630_28480	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
RvVAR0630_28490	COG2205	protein histidine kinase activity
RvVAR0630_28500	COG0745	RESPONSE REGULATOR receiver
RvVAR0630_28510	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
RvVAR0630_28530	COG3088	subunit of a heme lyase
RvVAR0630_28540	COG1138	Cytochrome C-type biogenesis protein
RvVAR0630_28550	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
RvVAR0630_28560	COG4235	cytochrome complex assembly
RvVAR0630_28570	COG4520	surface antigen
RvVAR0630_28580	COG2205	protein histidine kinase activity
RvVAR0630_28590	COG0745	RESPONSE REGULATOR receiver
RvVAR0630_28790	COG4695	Portal protein
RvVAR0630_28830	COG0789	Transcriptional regulator
RvVAR0630_28860	COG2983	Belongs to the UPF0260 family
RvVAR0630_28870	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
RvVAR0630_28990	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
RvVAR0630_29020	COG2205	protein histidine kinase activity
RvVAR0630_29040	COG2166	iron-sulfur cluster assembly
RvVAR0630_29080	COG0577	efflux transmembrane transporter activity
RvVAR0630_29080	COG1136	(ABC) transporter
RvVAR0630_29090	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
RvVAR0630_29160	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
RvVAR0630_29180	COG2111	Na H antiporter
RvVAR0630_29190	COG1006	Multisubunit Na H antiporter MnhC subunit
RvVAR0630_29210	COG1863	multisubunit Na H antiporter MnhE subunit
RvVAR0630_29220	COG2212	antiporter activity
RvVAR0630_29230	COG1320	monovalent cation:proton antiporter activity
RvVAR0630_29240	COG4957	zinc ion binding
RvVAR0630_29280	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
RvVAR0630_29290	COG1272	protein, Hemolysin III
RvVAR0630_29300	COG3788	relative of glutathione S-transferase, MAPEG superfamily
RvVAR0630_29330	COG2514	catechol 2,3-dioxygenase activity
RvVAR0630_29420	COG3293	Transposase
RvVAR0630_29450	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
RvVAR0630_29460	COG3447	MASE1 domain protein
RvVAR0630_29460	COG5001	Diguanylate cyclase
RvVAR0630_29460	COG5002	protein histidine kinase activity
RvVAR0630_29480	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
RvVAR0630_29490	COG1733	regulation of RNA biosynthetic process
RvVAR0630_29500	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
RvVAR0630_29510	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
RvVAR0630_29540	COG2010	Cytochrome c
RvVAR0630_29580	COG2226	methyltransferase
RvVAR0630_29610	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
RvVAR0630_29620	COG1120	ATPase activity
RvVAR0630_29640	COG3077	Addiction module antitoxin, RelB DinJ family
RvVAR0630_29670	COG1940	carbohydrate kinase activity
RvVAR0630_29670	COG1846	Transcriptional regulator
RvVAR0630_29680	COG4213	ABC transporter substrate-binding protein
RvVAR0630_29700	COG4214	carbohydrate transport
RvVAR0630_29720	COG1968	undecaprenyl-diphosphatase activity
RvVAR0630_29730	COG0840	transmembrane signaling receptor activity
RvVAR0630_29750	COG1473	amidohydrolase
RvVAR0630_29760	COG0433	COG0433 Predicted ATPase
RvVAR0630_29780	COG0840	transmembrane signaling receptor activity
RvVAR0630_29790	COG0840	transmembrane signaling receptor activity
RvVAR0630_29800	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
RvVAR0630_29810	COG3265	gluconokinase activity
RvVAR0630_29820	COG0784	Response regulator, receiver
RvVAR0630_29820	COG4191	Histidine kinase
RvVAR0630_29870	COG1764	response to oxidative stress
RvVAR0630_29880	COG1846	Transcriptional regulator
RvVAR0630_29890	COG1376	ErfK ybiS ycfS ynhG family protein
RvVAR0630_29900	COG1388	LysM domain
RvVAR0630_29900	COG1376	ErfK ybiS ycfS ynhG family protein
RvVAR0630_29940	COG0778	Nitroreductase
RvVAR0630_29960	COG0477	Major facilitator Superfamily
RvVAR0630_30060	COG1349	DNA-binding transcription factor activity
RvVAR0630_30110	COG0840	transmembrane signaling receptor activity
RvVAR0630_30130	COG4943	cyclic-guanylate-specific phosphodiesterase activity
RvVAR0630_30140	COG1309	transcriptional regulator
RvVAR0630_30150	COG3119	arylsulfatase activity
RvVAR0630_30160	COG0625	glutathione transferase activity
RvVAR0630_30170	COG1012	belongs to the aldehyde dehydrogenase family
RvVAR0630_30190	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
RvVAR0630_30240	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
RvVAR0630_30250	COG0038	chloride channel
RvVAR0630_30490	COG0693	protein deglycase activity
RvVAR0630_30510	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
RvVAR0630_30530	COG1609	Transcriptional regulator
RvVAR0630_30550	COG2895	sulfate adenylyltransferase (ATP) activity
RvVAR0630_30560	COG0175	sulfate reduction
RvVAR0630_30570	COG0175	sulfate reduction
RvVAR0630_30580	COG0840	transmembrane signaling receptor activity
RvVAR0630_30610	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
RvVAR0630_30680	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
RvVAR0630_30680	COG0574	Belongs to the PEP-utilizing enzyme family
RvVAR0630_30710	COG2814	Major facilitator Superfamily
RvVAR0630_30730	COG1196	nuclear chromosome segregation
RvVAR0630_30760	COG1194	a g-specific adenine glycosylase
RvVAR0630_30820	COG2189	Belongs to the N(4) N(6)-methyltransferase family
RvVAR0630_30840	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
RvVAR0630_30880	COG0612	Peptidase, M16
RvVAR0630_30890	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
RvVAR0630_30910	COG5001	Diguanylate cyclase
RvVAR0630_30920	COG0640	Transcriptional regulator
RvVAR0630_30940	COG1678	Uncharacterized ACR, COG1678
RvVAR0630_30960	COG0678	peroxiredoxin activity
RvVAR0630_30960	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
RvVAR0630_30990	COG0803	Belongs to the bacterial solute-binding protein 9 family
RvVAR0630_31010	COG0328	RNA-DNA hybrid ribonuclease activity
RvVAR0630_31020	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
RvVAR0630_31040	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
RvVAR0630_31060	COG3346	SURF1 family
RvVAR0630_31090	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
RvVAR0630_31110	COG0109	protoheme IX farnesyltransferase activity
RvVAR0630_31120	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
RvVAR0630_31150	COG0312	modulator of DNA gyrase
RvVAR0630_31170	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
RvVAR0630_31200	COG1686	Belongs to the peptidase S11 family
RvVAR0630_31210	COG0789	Transcriptional regulator
RvVAR0630_31220	COG2814	Major facilitator Superfamily
RvVAR0630_31240	COG0259	pyridoxamine-phosphate oxidase activity
RvVAR0630_31260	COG0484	heat shock protein binding
RvVAR0630_31270	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
RvVAR0630_31300	COG3300	MHYT domain
RvVAR0630_31300	COG5001	Diguanylate cyclase
RvVAR0630_31310	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
RvVAR0630_31320	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
RvVAR0630_31320	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
RvVAR0630_31370	COG3214	Protein conserved in bacteria
RvVAR0630_31390	COG1122	ATPase activity
RvVAR0630_31400	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
RvVAR0630_31410	COG1268	BioY protein
RvVAR0630_31440	COG0123	including yeast histone deacetylase and acetoin utilization protein
RvVAR0630_31450	COG1722	exodeoxyribonuclease VII activity
RvVAR0630_31460	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
RvVAR0630_31470	COG0840	transmembrane signaling receptor activity
RvVAR0630_31480	COG0840	transmembrane signaling receptor activity
RvVAR0630_31500	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
RvVAR0630_31520	COG1024	Enoyl-CoA hydratase
RvVAR0630_31530	COG1960	acyl-CoA dehydrogenase activity
RvVAR0630_31580	COG4638	Rieske (2fe-2S)
RvVAR0630_31590	COG0840	transmembrane signaling receptor activity
RvVAR0630_31610	COG0009	L-threonylcarbamoyladenylate synthase
RvVAR0630_31630	COG3585	molybdate ion transport
RvVAR0630_31630	COG2005	Transcriptional regulator
RvVAR0630_31650	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
RvVAR0630_31660	COG4149	molybdate abc transporter
RvVAR0630_31670	COG0725	ABC transporter, periplasmic molybdate-binding protein
RvVAR0630_31730	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
RvVAR0630_31740	COG2183	response to ionizing radiation
RvVAR0630_31760	COG0151	Belongs to the GarS family
RvVAR0630_31780	COG0840	transmembrane signaling receptor activity
RvVAR0630_31790	COG1683	Conserved Protein
RvVAR0630_31800	COG0751	glycine-tRNA ligase activity
RvVAR0630_31810	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
RvVAR0630_31830	COG0752	glycyl-tRNA synthetase alpha subunit
RvVAR0630_31890	COG0142	geranyltranstransferase activity
RvVAR0630_31910	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
RvVAR0630_31920	COG0521	Mo-molybdopterin cofactor biosynthetic process
RvVAR0630_31950	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
RvVAR0630_31960	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
RvVAR0630_31970	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
RvVAR0630_31990	COG0356	it plays a direct role in the translocation of protons across the membrane
RvVAR0630_32010	COG3158	transport of potassium into the cell
RvVAR0630_32060	COG2771	luxR family
RvVAR0630_32070	COG3386	PFAM SMP-30 Gluconolaconase
RvVAR0630_32100	COG0477	Major facilitator Superfamily
RvVAR0630_32120	COG0590	tRNA wobble adenosine to inosine editing
RvVAR0630_32130	COG1187	pseudouridine synthase activity
RvVAR0630_32140	COG0742	ribosomal rna small subunit methyltransferase
RvVAR0630_32190	COG0475	glutathione-regulated potassium exporter activity
RvVAR0630_32190	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
RvVAR0630_32200	COG0312	modulator of DNA gyrase
RvVAR0630_32210	COG1218	3'(2'),5'-bisphosphate nucleotidase
RvVAR0630_32230	COG1519	Transferase
RvVAR0630_32250	COG1663	tetraacyldisaccharide 4'-kinase activity
RvVAR0630_32270	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
RvVAR0630_32280	COG0784	Response regulator, receiver
RvVAR0630_32280	COG5002	protein histidine kinase activity
RvVAR0630_32280	COG2198	Histidine kinase
RvVAR0630_32290	COG5001	Diguanylate cyclase
RvVAR0630_32290	COG3300	MHYT domain
RvVAR0630_32310	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
RvVAR0630_32320	COG0248	Ppx GppA phosphatase
RvVAR0630_32410	COG0840	transmembrane signaling receptor activity
RvVAR0630_32430	COG0579	oxidoreductase
RvVAR0630_32440	COG0745	RESPONSE REGULATOR receiver
RvVAR0630_32470	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
RvVAR0630_32480	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
RvVAR0630_32490	COG2134	cdp-diacylglycerol pyrophosphatase
RvVAR0630_32500	COG3265	gluconokinase activity
RvVAR0630_32510	COG1959	2 iron, 2 sulfur cluster binding
RvVAR0630_32600	COG2205	protein histidine kinase activity
RvVAR0630_32620	COG1177	transmembrane transport
RvVAR0630_32630	COG1176	ABC-type spermidine putrescine transport system, permease component I
RvVAR0630_32640	COG3842	ATPase activity
RvVAR0630_32670	COG2224	Isocitrate lyase
RvVAR0630_32730	COG0840	transmembrane signaling receptor activity
RvVAR0630_32730	COG2972	Histidine kinase
RvVAR0630_32770	COG2081	HI0933 family
RvVAR0630_32790	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
RvVAR0630_32800	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
RvVAR0630_32810	COG0363	glucosamine-6-phosphate deaminase activity
RvVAR0630_32820	COG0129	dihydroxy-acid dehydratase activity
RvVAR0630_32840	COG3493	citrate carrier protein
RvVAR0630_32870	COG3842	ATPase activity
RvVAR0630_32880	COG0366	Alpha amylase catalytic
RvVAR0630_32890	COG0395	ABC-type sugar transport system, permease component
RvVAR0630_32900	COG1175	transmembrane transport
RvVAR0630_32910	COG1653	transport
RvVAR0630_32920	COG1609	Transcriptional regulator
RvVAR0630_32930	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
RvVAR0630_33010	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
RvVAR0630_33020	COG4794	Type iii secretion
RvVAR0630_33030	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
RvVAR0630_33040	COG5443	negative regulation of bacterial-type flagellum assembly
RvVAR0630_33080	COG1749	Flagellar hook protein flgE
RvVAR0630_33140	COG1360	Flagellar Motor Protein
RvVAR0630_33160	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
RvVAR0630_33170	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
RvVAR0630_33180	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
RvVAR0630_33190	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
RvVAR0630_33200	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
RvVAR0630_33210	COG1338	Plays a role in the flagellum-specific transport system
RvVAR0630_33230	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
RvVAR0630_33250	COG1706	bacterial-type flagellum-dependent cell motility
RvVAR0630_33260	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
RvVAR0630_33270	COG4786	Flagellar basal body rod
RvVAR0630_33280	COG1677	Flagellar hook-basal body complex protein FliE
RvVAR0630_33290	COG1558	bacterial-type flagellum-dependent cell motility
RvVAR0630_33300	COG1815	bacterial-type flagellum-dependent cell motility
RvVAR0630_33320	COG1157	protein secretion by the type III secretion system
RvVAR0630_33330	COG4786	Flagellar basal body rod
RvVAR0630_33340	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
RvVAR0630_33350	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
RvVAR0630_33360	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
RvVAR0630_33370	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
RvVAR0630_33380	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
RvVAR0630_33440	COG0488	(ABC) transporter
RvVAR0630_33460	COG1215	transferase activity, transferring glycosyl groups
RvVAR0630_33520	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
RvVAR0630_33540	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
RvVAR0630_33550	COG5328	Belongs to the UPF0262 family
RvVAR0630_33570	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
RvVAR0630_33580	COG0424	maF-like protein
RvVAR0630_33590	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
RvVAR0630_33630	COG1216	Glycosyl transferase, family 2
RvVAR0630_33670	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
RvVAR0630_33690	COG0436	Aminotransferase
RvVAR0630_33700	COG1970	mechanosensitive ion channel activity
RvVAR0630_33710	COG0784	Response regulator, receiver
RvVAR0630_33710	COG2205	protein histidine kinase activity
RvVAR0630_33710	COG2198	Histidine kinase
RvVAR0630_33720	COG1047	Peptidyl-prolyl cis-trans
RvVAR0630_33760	COG1201	RNA secondary structure unwinding
RvVAR0630_33780	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
RvVAR0630_33790	COG3706	GGDEF domain
RvVAR0630_33790	COG2203	Gaf domain
RvVAR0630_33790	COG5001	Diguanylate cyclase
RvVAR0630_33790	COG4251	negative regulation of phosphorylation
RvVAR0630_33820	COG1136	(ABC) transporter
RvVAR0630_33840	COG1785	Belongs to the alkaline phosphatase family
RvVAR0630_33880	COG1960	acyl-CoA dehydrogenase activity
RvVAR0630_33890	COG0183	Belongs to the thiolase family
RvVAR0630_33900	COG1250	3-hydroxyacyl-CoA dehydrogenase
RvVAR0630_33900	COG1024	Enoyl-CoA hydratase
RvVAR0630_33980	COG0167	dihydroorotate dehydrogenase activity
RvVAR0630_34030	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RvVAR0630_34080	COG0587	DNA-directed DNA polymerase activity
RvVAR0630_34100	COG3293	Transposase
RvVAR0630_34140	COG0307	riboflavin synthase, alpha
RvVAR0630_34150	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
RvVAR0630_34170	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
RvVAR0630_34170	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
RvVAR0630_34180	COG3475	LICD family
RvVAR0630_34220	COG3246	L-lysine catabolic process to acetate
RvVAR0630_34230	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
RvVAR0630_34270	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
RvVAR0630_34290	COG0732	type I restriction modification DNA specificity domain
RvVAR0630_34300	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
RvVAR0630_34310	COG3501	Rhs element vgr protein
RvVAR0630_34520	COG0717	Belongs to the dCTP deaminase family
RvVAR0630_34540	COG2967	ApaG domain
RvVAR0630_34550	COG0242	peptide deformylase activity
RvVAR0630_34560	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
RvVAR0630_34570	COG0101	tRNA pseudouridine synthase activity
RvVAR0630_34630	COG0318	PFAM AMP-dependent synthetase and ligase
RvVAR0630_34640	COG0166	Belongs to the GPI family
RvVAR0630_34650	COG1028	Short-chain dehydrogenase reductase Sdr
RvVAR0630_34670	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
RvVAR0630_34680	COG3706	GGDEF domain
RvVAR0630_34690	COG0418	dihydroorotase activity
RvVAR0630_34730	COG0745	RESPONSE REGULATOR receiver
RvVAR0630_34740	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
RvVAR0630_34750	COG3938	Belongs to the proline racemase family
RvVAR0630_34770	COG0427	acetyl-CoA hydrolase
RvVAR0630_34810	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
RvVAR0630_34830	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
RvVAR0630_34840	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
RvVAR0630_34860	COG2986	histidine ammonia-lyase
RvVAR0630_34870	COG2188	Transcriptional regulator
RvVAR0630_34910	COG0517	IMP dehydrogenase activity
RvVAR0630_34910	COG1125	glycine betaine transport
RvVAR0630_34940	COG2326	polyphosphate kinase activity
RvVAR0630_34950	COG5002	protein histidine kinase activity
RvVAR0630_34970	COG0573	inorganic phosphate transmembrane transporter activity
RvVAR0630_34990	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
RvVAR0630_35000	COG0704	Plays a role in the regulation of phosphate uptake
RvVAR0630_35010	COG0745	RESPONSE REGULATOR receiver
RvVAR0630_35030	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
RvVAR0630_35040	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
RvVAR0630_35100	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
RvVAR0630_35110	COG2171	N-acyltransferase activity
RvVAR0630_35150	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
RvVAR0630_35160	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
RvVAR0630_35200	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
RvVAR0630_35210	COG0218	Necessary for normal cell division and for the maintenance of normal septation
RvVAR0630_35220	COG0706	membrane insertase activity
RvVAR0630_35230	COG0594	ribonuclease P activity
RvVAR0630_35240	COG2205	protein histidine kinase activity
RvVAR0630_35260	COG0840	transmembrane signaling receptor activity
RvVAR0630_35290	COG0069	glutamate synthase activity
RvVAR0630_35300	COG2218	PFAM glutamate synthase alpha subunit domain protein
RvVAR0630_35310	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
RvVAR0630_35330	COG4977	sequence-specific DNA binding
RvVAR0630_35340	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
RvVAR0630_35350	COG4311	Sarcosine oxidase, delta subunit
RvVAR0630_35360	COG0446	pyridine nucleotide-disulphide oxidoreductase
RvVAR0630_35360	COG0404	The glycine cleavage system catalyzes the degradation of glycine
RvVAR0630_35410	COG0395	ABC-type sugar transport system, permease component
RvVAR0630_35420	COG1175	transmembrane transport
RvVAR0630_35490	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
RvVAR0630_35520	COG0626	cystathionine gamma-synthase activity
RvVAR0630_35560	COG3386	PFAM SMP-30 Gluconolaconase
RvVAR0630_35580	COG2084	Dehydrogenase
RvVAR0630_35590	COG1012	belongs to the aldehyde dehydrogenase family
RvVAR0630_35600	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
RvVAR0630_35620	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
RvVAR0630_35640	COG0395	ABC-type sugar transport system, permease component
RvVAR0630_35650	COG1175	transmembrane transport
RvVAR0630_35660	COG3842	ATPase activity
RvVAR0630_35680	COG0640	Transcriptional regulator
RvVAR0630_35700	COG2186	Transcriptional regulator
RvVAR0630_35710	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
RvVAR0630_35720	COG0747	negative chemotaxis
RvVAR0630_35730	COG0601	transmembrane transport
RvVAR0630_35740	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RvVAR0630_35750	COG4172	Belongs to the ABC transporter superfamily
RvVAR0630_35770	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
RvVAR0630_35780	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
RvVAR0630_35780	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
RvVAR0630_35790	COG1028	Short-chain dehydrogenase reductase Sdr
RvVAR0630_35810	COG1566	PFAM secretion protein HlyD family protein
RvVAR0630_35850	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
RvVAR0630_35850	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
RvVAR0630_35870	COG4770	biotin carboxylase activity
RvVAR0630_35900	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
RvVAR0630_35930	COG1309	transcriptional regulator
RvVAR0630_35940	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
RvVAR0630_35960	COG1012	belongs to the aldehyde dehydrogenase family
RvVAR0630_35970	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
RvVAR0630_36030	COG0601	transmembrane transport
RvVAR0630_36040	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RvVAR0630_36050	COG4172	Belongs to the ABC transporter superfamily
RvVAR0630_36100	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
RvVAR0630_36130	COG1129	ABC transporter
RvVAR0630_36140	COG1335	isochorismatase
RvVAR0630_36170	COG0154	amidase activity
RvVAR0630_36200	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RvVAR0630_36220	COG0747	negative chemotaxis
RvVAR0630_36230	COG0583	DNA-binding transcription factor activity
RvVAR0630_36270	COG0747	negative chemotaxis
RvVAR0630_36310	COG4608	Belongs to the ABC transporter superfamily
RvVAR0630_36330	COG1960	acyl-CoA dehydrogenase activity
RvVAR0630_36370	COG3321	synthase
RvVAR0630_36370	COG0604	alcohol dehydrogenase
RvVAR0630_36440	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
RvVAR0630_36470	COG3833	ABC-type maltose transport systems, permease component
RvVAR0630_36480	COG3842	ATPase activity
RvVAR0630_36510	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
RvVAR0630_36510	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
RvVAR0630_36520	COG1132	(ABC) transporter
RvVAR0630_36560	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
RvVAR0630_36570	COG5001	Diguanylate cyclase
RvVAR0630_36630	COG3685	Protein conserved in bacteria
RvVAR0630_36660	COG3920	Histidine kinase
RvVAR0630_36670	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
RvVAR0630_36690	COG1028	Short-chain dehydrogenase reductase Sdr
RvVAR0630_36710	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
RvVAR0630_36730	COG0673	inositol 2-dehydrogenase activity
RvVAR0630_36750	COG0395	ABC-type sugar transport system, permease component
RvVAR0630_36760	COG1175	transmembrane transport
RvVAR0630_36780	COG0673	inositol 2-dehydrogenase activity
RvVAR0630_36800	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
RvVAR0630_36830	COG0673	inositol 2-dehydrogenase activity
RvVAR0630_36850	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
RvVAR0630_36860	COG1278	Cold shock
RvVAR0630_36870	COG1640	4-alpha-glucanotransferase
RvVAR0630_36880	COG0366	Alpha amylase catalytic
RvVAR0630_36890	COG0366	Alpha amylase catalytic
RvVAR0630_36900	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
RvVAR0630_36910	COG0789	Transcriptional regulator
RvVAR0630_36940	COG0404	The glycine cleavage system catalyzes the degradation of glycine
RvVAR0630_36970	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
RvVAR0630_36990	COG0835	chemotaxis
RvVAR0630_37000	COG2972	Histidine kinase
RvVAR0630_37000	COG0840	transmembrane signaling receptor activity
RvVAR0630_37010	COG1609	Transcriptional regulator
RvVAR0630_37030	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RvVAR0630_37040	COG1126	abc transporter atp-binding protein
RvVAR0630_37070	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
RvVAR0630_37080	COG0784	Response regulator, receiver
RvVAR0630_37080	COG4191	Histidine kinase
RvVAR0630_37090	COG1162	GTPase activity
RvVAR0630_37110	COG0784	Response regulator, receiver
RvVAR0630_37130	COG2202	Pas domain
RvVAR0630_37130	COG3920	Histidine kinase
RvVAR0630_37160	COG1215	transferase activity, transferring glycosyl groups
RvVAR0630_37190	COG2076	Multidrug Resistance protein
RvVAR0630_37230	COG2076	Multidrug Resistance protein
RvVAR0630_37250	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
RvVAR0630_37270	COG2205	protein histidine kinase activity
RvVAR0630_37280	COG0745	RESPONSE REGULATOR receiver
RvVAR0630_37290	COG4608	Belongs to the ABC transporter superfamily
RvVAR0630_37310	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RvVAR0630_37320	COG0601	transmembrane transport
RvVAR0630_37330	COG0747	negative chemotaxis
RvVAR0630_37340	COG1940	carbohydrate kinase activity
RvVAR0630_37410	COG1175	transmembrane transport
RvVAR0630_37420	COG0395	ABC-type sugar transport system, permease component
RvVAR0630_37430	COG3842	ATPase activity
RvVAR0630_37450	COG4566	intracellular signal transduction
RvVAR0630_37460	COG4191	Histidine kinase
RvVAR0630_37480	COG1116	anion transmembrane transporter activity
RvVAR0630_37500	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
RvVAR0630_37550	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
RvVAR0630_37620	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
RvVAR0630_37670	COG1959	2 iron, 2 sulfur cluster binding
RvVAR0630_37680	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
RvVAR0630_37690	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
RvVAR0630_37700	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
RvVAR0630_37710	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
RvVAR0630_37720	COG1116	anion transmembrane transporter activity
RvVAR0630_37750	COG1764	response to oxidative stress
RvVAR0630_37770	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
RvVAR0630_37780	COG0765	amino acid transport
RvVAR0630_37790	COG0765	amino acid transport
RvVAR0630_37800	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RvVAR0630_37810	COG1126	abc transporter atp-binding protein
RvVAR0630_37820	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
RvVAR0630_37830	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
RvVAR0630_37920	COG0179	Fumarylacetoacetate (FAA) hydrolase
RvVAR0630_37940	COG1304	FMN binding
RvVAR0630_37950	COG2186	Transcriptional regulator
RvVAR0630_37980	COG1012	belongs to the aldehyde dehydrogenase family
RvVAR0630_37990	COG2080	2 iron, 2 sulfur cluster binding
RvVAR0630_38000	COG1529	Aldehyde oxidase and xanthine dehydrogenase
RvVAR0630_38030	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
RvVAR0630_38060	COG0583	DNA-binding transcription factor activity
RvVAR0630_38070	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
RvVAR0630_38160	COG0402	S-adenosylhomocysteine deaminase activity
RvVAR0630_38170	COG2116	formate transmembrane transporter activity
RvVAR0630_38180	COG1940	carbohydrate kinase activity
RvVAR0630_38190	COG3250	beta-galactosidase activity
RvVAR0630_38200	COG0402	S-adenosylhomocysteine deaminase activity
RvVAR0630_38210	COG0583	DNA-binding transcription factor activity
RvVAR0630_38240	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
RvVAR0630_38260	COG3842	ATPase activity
RvVAR0630_38270	COG0395	ABC-type sugar transport system, permease component
RvVAR0630_38280	COG1175	transmembrane transport
RvVAR0630_38290	COG1653	transport
RvVAR0630_38310	COG0673	inositol 2-dehydrogenase activity
RvVAR0630_38320	COG1609	Transcriptional regulator
RvVAR0630_38330	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
RvVAR0630_38340	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
RvVAR0630_38350	COG4208	sulfate ABC transporter
RvVAR0630_38360	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
RvVAR0630_38390	COG4585	Histidine kinase
RvVAR0630_38400	COG2197	response regulator
RvVAR0630_38410	COG2205	protein histidine kinase activity
RvVAR0630_38430	COG0747	negative chemotaxis
RvVAR0630_38490	COG0601	transmembrane transport
RvVAR0630_38510	COG1802	Transcriptional regulator
RvVAR0630_38530	COG0318	PFAM AMP-dependent synthetase and ligase
RvVAR0630_38560	COG3789	protein conserved in bacteria
RvVAR0630_38580	COG3766	membrane
RvVAR0630_38600	COG0754	glutathionylspermidine amidase activity
RvVAR0630_38620	COG0405	Gamma-glutamyltransferase
RvVAR0630_38640	COG0601	transmembrane transport
RvVAR0630_38650	COG0747	negative chemotaxis
RvVAR0630_38670	COG0006	proline dipeptidase activity
RvVAR0630_38680	COG4608	Belongs to the ABC transporter superfamily
RvVAR0630_38690	COG0444	Belongs to the ABC transporter superfamily
RvVAR0630_38720	COG0747	negative chemotaxis
RvVAR0630_38730	COG1725	Transcriptional regulator
RvVAR0630_38740	COG0626	cystathionine gamma-synthase activity
RvVAR0630_38760	COG1028	Short-chain dehydrogenase reductase Sdr
RvVAR0630_38800	COG2390	Transcriptional regulator
RvVAR0630_38810	COG3684	Belongs to the aldolase LacD family
RvVAR0630_38860	COG0395	ABC-type sugar transport system, permease component
RvVAR0630_38870	COG1175	transmembrane transport
RvVAR0630_38880	COG3842	ATPase activity
RvVAR0630_38900	COG0306	phosphate transporter
RvVAR0630_38910	COG0753	catalase activity
RvVAR0630_38940	COG0438	transferase activity, transferring glycosyl groups
RvVAR0630_38980	COG2133	pyrroloquinoline quinone binding
RvVAR0630_39020	COG0625	glutathione transferase activity
RvVAR0630_39080	COG1846	Transcriptional regulator
RvVAR0630_39090	COG1028	Short-chain dehydrogenase reductase Sdr
RvVAR0630_39100	COG1172	Belongs to the binding-protein-dependent transport system permease family
RvVAR0630_39120	COG1129	ABC transporter
RvVAR0630_39130	COG1129	ABC transporter
RvVAR0630_39150	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RvVAR0630_39160	COG0601	transmembrane transport
RvVAR0630_39220	COG4172	Belongs to the ABC transporter superfamily
RvVAR0630_39280	COG0583	DNA-binding transcription factor activity
RvVAR0630_39290	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
RvVAR0630_39300	COG3842	ATPase activity
RvVAR0630_39310	COG1176	ABC-type spermidine putrescine transport system, permease component I
RvVAR0630_39320	COG1177	transmembrane transport
RvVAR0630_39330	COG2072	flavoprotein involved in K transport
RvVAR0630_39360	COG0402	S-adenosylhomocysteine deaminase activity
RvVAR0630_39370	COG0402	S-adenosylhomocysteine deaminase activity
RvVAR0630_39430	COG2111	Na H antiporter
RvVAR0630_39430	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
RvVAR0630_39440	COG1006	Multisubunit Na H antiporter MnhC subunit
RvVAR0630_39450	COG0651	ATP synthesis coupled electron transport
RvVAR0630_39460	COG1863	multisubunit Na H antiporter MnhE subunit
RvVAR0630_39470	COG2212	antiporter activity
RvVAR0630_39480	COG1320	monovalent cation:proton antiporter activity
RvVAR0630_39560	COG0584	glycerophosphoryl diester phosphodiesterase
RvVAR0630_39570	COG3842	ATPase activity
RvVAR0630_39580	COG3833	ABC-type maltose transport systems, permease component
RvVAR0630_39630	COG4993	Dehydrogenase
RvVAR0630_39640	COG2824	Alkylphosphonate utilization operon protein PhnA
RvVAR0630_39650	COG1595	DNA-templated transcription, initiation
RvVAR0630_39710	COG0300	oxidoreductase activity
RvVAR0630_39750	COG0235	Class ii aldolase
RvVAR0630_39770	COG2207	Transcriptional regulator
RvVAR0630_39860	COG1960	acyl-CoA dehydrogenase activity
RvVAR0630_39880	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
RvVAR0630_39920	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
RvVAR0630_39940	COG0745	RESPONSE REGULATOR receiver
RvVAR0630_39950	COG2205	protein histidine kinase activity
RvVAR0630_39960	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
RvVAR0630_40010	COG1473	amidohydrolase
RvVAR0630_40020	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
RvVAR0630_40030	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
RvVAR0630_40040	COG1609	Transcriptional regulator
RvVAR0630_40050	COG2271	Major facilitator Superfamily
RvVAR0630_40060	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
RvVAR0630_40070	COG2731	YhcH YjgK YiaL family protein
RvVAR0630_40090	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
RvVAR0630_40100	COG3850	Histidine kinase
RvVAR0630_40100	COG5002	protein histidine kinase activity
RvVAR0630_40110	COG2197	response regulator
RvVAR0630_40160	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RvVAR0630_40180	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
RvVAR0630_40200	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
RvVAR0630_40210	COG2079	MmgE PrpD family protein
RvVAR0630_40230	COG0765	amino acid transport
RvVAR0630_40260	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
RvVAR0630_40270	COG1172	Belongs to the binding-protein-dependent transport system permease family
RvVAR0630_40290	COG1129	ABC transporter
RvVAR0630_40320	COG4213	ABC transporter substrate-binding protein
RvVAR0630_40330	COG1129	ABC transporter
RvVAR0630_40340	COG1172	Belongs to the binding-protein-dependent transport system permease family
RvVAR0630_40370	COG0667	Aldo Keto reductase
RvVAR0630_40420	COG2972	Histidine kinase
RvVAR0630_40420	COG0840	transmembrane signaling receptor activity
RvVAR0630_40450	COG1172	Belongs to the binding-protein-dependent transport system permease family
RvVAR0630_40480	COG1609	Transcriptional regulator
RvVAR0630_40520	COG0395	ABC-type sugar transport system, permease component
RvVAR0630_40530	COG1175	transmembrane transport
RvVAR0630_40560	COG1129	ABC transporter
RvVAR0630_40570	COG4214	carbohydrate transport
RvVAR0630_40610	COG4948	Mandelate Racemase Muconate Lactonizing
RvVAR0630_40620	COG1063	alcohol dehydrogenase
RvVAR0630_40650	COG0745	RESPONSE REGULATOR receiver
RvVAR0630_40670	COG2207	Transcriptional regulator
RvVAR0630_40670	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
RvVAR0630_40680	COG1486	melibiose metabolic process
RvVAR0630_40690	COG0747	negative chemotaxis
RvVAR0630_40700	COG0601	transmembrane transport
RvVAR0630_40710	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RvVAR0630_40720	COG4172	Belongs to the ABC transporter superfamily
RvVAR0630_40730	COG1486	melibiose metabolic process
RvVAR0630_40740	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
RvVAR0630_40790	COG1529	Aldehyde oxidase and xanthine dehydrogenase
RvVAR0630_40800	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
RvVAR0630_40810	COG2080	2 iron, 2 sulfur cluster binding
RvVAR0630_40840	COG3706	GGDEF domain
RvVAR0630_40840	COG4251	negative regulation of phosphorylation
RvVAR0630_40840	COG2203	Gaf domain
RvVAR0630_40840	COG5001	Diguanylate cyclase
RvVAR0630_40870	COG1921	L-seryl-tRNASec selenium transferase activity
RvVAR0630_40900	COG3964	amidohydrolase
RvVAR0630_40920	COG0601	transmembrane transport
RvVAR0630_40930	COG2723	6-phospho-beta-galactosidase activity
RvVAR0630_40950	COG1802	Transcriptional regulator
RvVAR0630_40970	COG0179	Fumarylacetoacetate (FAA) hydrolase
RvVAR0630_41110	COG0589	response to stress
RvVAR0630_41120	COG0659	secondary active sulfate transmembrane transporter activity
RvVAR0630_41130	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
RvVAR0630_41150	COG0778	Nitroreductase
RvVAR0630_41190	COG1116	anion transmembrane transporter activity
RvVAR0630_41200	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
RvVAR0630_41220	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
RvVAR0630_41240	COG1012	belongs to the aldehyde dehydrogenase family
RvVAR0630_41250	COG1012	belongs to the aldehyde dehydrogenase family
RvVAR0630_41260	COG2186	Transcriptional regulator
RvVAR0630_41270	COG1172	Belongs to the binding-protein-dependent transport system permease family
RvVAR0630_41280	COG1172	Belongs to the binding-protein-dependent transport system permease family
RvVAR0630_41290	COG1129	ABC transporter
RvVAR0630_41300	COG1879	ABC-type sugar transport system periplasmic component
RvVAR0630_41340	COG1129	ABC transporter
RvVAR0630_41370	COG1609	Transcriptional regulator
RvVAR0630_41390	COG2084	Dehydrogenase
RvVAR0630_41400	COG3265	gluconokinase activity
RvVAR0630_41410	COG1028	Short-chain dehydrogenase reductase Sdr
RvVAR0630_41420	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
RvVAR0630_41430	COG1063	alcohol dehydrogenase
RvVAR0630_41480	COG0297	glycogen (starch) synthase activity
RvVAR0630_41500	COG1473	amidohydrolase
RvVAR0630_41510	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
RvVAR0630_41530	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
RvVAR0630_41540	COG2040	homocysteine
RvVAR0630_41560	COG4215	(ABC) transporter
RvVAR0630_41590	COG1522	sequence-specific DNA binding
RvVAR0630_41640	COG3257	ureidoglycine aminohydrolase activity
RvVAR0630_41650	COG0392	lysyltransferase activity
RvVAR0630_41660	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
RvVAR0630_41670	COG0640	Transcriptional regulator
RvVAR0630_41690	COG1475	DNA binding
RvVAR0630_41700	COG1192	Involved in chromosome partitioning
RvVAR0630_41720	COG4303	Ethanolamine ammonia lyase large subunit
RvVAR0630_41750	COG4181	ATPase activity
RvVAR0630_41760	COG2094	Belongs to the DNA glycosylase MPG family
RvVAR0630_41790	COG3842	ATPase activity
RvVAR0630_41810	COG1176	ABC-type spermidine putrescine transport system, permease component I
RvVAR0630_41820	COG0395	ABC-type sugar transport system, permease component
RvVAR0630_41840	COG5001	Diguanylate cyclase
RvVAR0630_41850	COG0179	Fumarylacetoacetate (FAA) hydrolase
RvVAR0630_41870	COG3254	rhamnose metabolic process
RvVAR0630_41890	COG1172	Belongs to the binding-protein-dependent transport system permease family
RvVAR0630_41900	COG1129	ABC transporter
RvVAR0630_41930	COG1028	Short-chain dehydrogenase reductase Sdr
RvVAR0630_41930	COG3347	Dehydrogenase
RvVAR0630_41940	COG4952	isomerase
RvVAR0630_41970	COG0745	RESPONSE REGULATOR receiver
RvVAR0630_41980	COG0642	Histidine kinase
RvVAR0630_42020	COG3142	Participates in the control of copper homeostasis
RvVAR0630_42030	COG2814	Major facilitator Superfamily
RvVAR0630_42060	COG1028	Short-chain dehydrogenase reductase Sdr
RvVAR0630_42070	COG1737	Transcriptional regulator
RvVAR0630_42070	COG0837	glucose binding
RvVAR0630_42120	COG3842	ATPase activity
RvVAR0630_42140	COG0395	ABC-type sugar transport system, permease component
RvVAR0630_42170	COG2188	Transcriptional regulator
RvVAR0630_42180	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
RvVAR0630_42190	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
RvVAR0630_42220	COG1309	transcriptional regulator
RvVAR0630_42230	COG2204	response regulator
RvVAR0630_42240	COG4191	Histidine kinase
RvVAR0630_42250	COG1301	dicarboxylic acid transport
RvVAR0630_42260	COG2273	Hydrolase Family 16
RvVAR0630_42260	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
RvVAR0630_42290	COG0670	Belongs to the BI1 family
RvVAR0630_42310	COG1595	DNA-templated transcription, initiation
RvVAR0630_42330	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
RvVAR0630_42340	COG1845	cytochrome c oxidase, subunit III
RvVAR0630_42350	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
RvVAR0630_42360	COG3346	SURF1 family
RvVAR0630_42380	COG0745	RESPONSE REGULATOR receiver
RvVAR0630_42390	COG2205	protein histidine kinase activity
RvVAR0630_42400	COG5265	(ABC) transporter
RvVAR0630_42440	COG0668	transmembrane transport
RvVAR0630_42470	COG3842	ATPase activity
RvVAR0630_42480	COG1674	ftsk spoiiie
RvVAR0630_42490	COG0604	alcohol dehydrogenase
RvVAR0630_42510	COG3485	protocatechuate 3,4-dioxygenase
RvVAR0630_42520	COG3485	protocatechuate 3,4-dioxygenase
RvVAR0630_42530	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
RvVAR0630_42540	COG2267	carboxylic ester hydrolase activity
RvVAR0630_42560	COG0583	DNA-binding transcription factor activity
RvVAR0630_42590	COG1414	Transcriptional regulator
RvVAR0630_42610	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
RvVAR0630_42620	COG0183	Belongs to the thiolase family
RvVAR0630_42690	COG0745	RESPONSE REGULATOR receiver
RvVAR0630_42700	COG2205	protein histidine kinase activity
RvVAR0630_42720	COG1028	Short-chain dehydrogenase reductase Sdr
RvVAR0630_42740	COG2721	sulfolactate sulfo-lyase activity
RvVAR0630_42790	COG1129	ABC transporter
RvVAR0630_42810	COG1172	Belongs to the binding-protein-dependent transport system permease family
RvVAR0630_42830	COG4154	Belongs to the RbsD FucU family
RvVAR0630_42850	COG1012	belongs to the aldehyde dehydrogenase family
RvVAR0630_42860	COG3842	ATPase activity
RvVAR0630_42870	COG1177	transmembrane transport
RvVAR0630_42900	COG1012	belongs to the aldehyde dehydrogenase family
RvVAR0630_42910	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
RvVAR0630_42930	COG2267	carboxylic ester hydrolase activity
RvVAR0630_42960	COG1522	sequence-specific DNA binding
RvVAR0630_42970	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
RvVAR0630_42980	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
RvVAR0630_43020	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
RvVAR0630_43040	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
RvVAR0630_43050	COG2205	protein histidine kinase activity
RvVAR0630_43060	COG0745	RESPONSE REGULATOR receiver
RvVAR0630_43080	COG0431	NADPH-dependent FMN reductase
RvVAR0630_43100	COG0798	PFAM Bile acid sodium symporter
RvVAR0630_43110	COG0640	Transcriptional regulator
RvVAR0630_43360	COG3415	Transposase
RvVAR0630_43370	COG3335	DDE superfamily endonuclease
RvVAR0630_43400	COG3321	synthase
RvVAR0630_43400	COG4221	oxidoreductase activity
RvVAR0630_43400	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
RvVAR0630_43400	COG1028	Short-chain dehydrogenase reductase Sdr
RvVAR0630_43480	COG4221	oxidoreductase activity
RvVAR0630_43480	COG3321	synthase
RvVAR0630_43480	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
RvVAR0630_43480	COG0300	oxidoreductase activity
RvVAR0630_43490	COG0367	asparagine synthase
RvVAR0630_43500	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
RvVAR0630_43510	COG2070	2-Nitropropane dioxygenase
RvVAR0630_43510	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
RvVAR0630_43570	COG2022	thiamine diphosphate biosynthetic process
RvVAR0630_43600	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
RvVAR0630_43630	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
RvVAR0630_43660	COG1804	L-carnitine dehydratase bile acid-inducible protein F
RvVAR0630_43670	COG1960	acyl-CoA dehydrogenase activity
RvVAR0630_43680	COG0583	DNA-binding transcription factor activity
RvVAR0630_43720	COG3707	response regulator
RvVAR0630_43730	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
RvVAR0630_43740	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
RvVAR0630_43750	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
RvVAR0630_43760	COG1116	anion transmembrane transporter activity
RvVAR0630_43770	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
RvVAR0630_43790	COG0243	molybdopterin cofactor binding
RvVAR0630_43810	COG0659	secondary active sulfate transmembrane transporter activity
RvVAR0630_43830	COG1522	sequence-specific DNA binding
RvVAR0630_43860	COG0523	cobalamin synthesis protein
RvVAR0630_43880	COG0726	polysaccharide deacetylase
RvVAR0630_43890	COG3842	ATPase activity
RvVAR0630_43910	COG1028	Short-chain dehydrogenase reductase Sdr
RvVAR0630_43920	COG1028	Short-chain dehydrogenase reductase Sdr
RvVAR0630_43940	COG1176	ABC-type spermidine putrescine transport system, permease component I
RvVAR0630_43950	COG3842	ATPase activity
RvVAR0630_43970	COG1984	allophanate hydrolase subunit 2
RvVAR0630_43990	COG0439	Biotin carboxylase
RvVAR0630_44000	COG0511	ligase activity, forming carbon-carbon bonds
RvVAR0630_44010	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
RvVAR0630_44020	COG0583	DNA-binding transcription factor activity
RvVAR0630_44040	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
RvVAR0630_44070	COG2515	1-aminocyclopropane-1-carboxylate deaminase
RvVAR0630_44080	COG1522	sequence-specific DNA binding
RvVAR0630_44090	COG1802	Transcriptional regulator
RvVAR0630_44100	COG1914	H( )-stimulated, divalent metal cation uptake system
RvVAR0630_44110	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
RvVAR0630_44120	COG4336	lyase activity
RvVAR0630_44130	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
RvVAR0630_44140	COG4770	biotin carboxylase activity
RvVAR0630_44160	COG0019	diaminopimelate decarboxylase activity
RvVAR0630_44170	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
RvVAR0630_44180	COG1177	transmembrane transport
RvVAR0630_44190	COG1176	ABC-type spermidine putrescine transport system, permease component I
RvVAR0630_44210	COG3842	ATPase activity
RvVAR0630_44250	COG0459	protein refolding
RvVAR0630_44260	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
RvVAR0630_44270	COG2059	Chromate
RvVAR0630_44290	COG0196	riboflavin kinase activity
RvVAR0630_44320	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
RvVAR0630_44350	COG2130	NADP-dependent
RvVAR0630_44360	COG2137	regulation of response to DNA damage stimulus
RvVAR0630_44380	COG2909	trisaccharide binding
RvVAR0630_44390	COG1376	ErfK ybiS ycfS ynhG family protein
RvVAR0630_44400	COG1388	LysM domain
RvVAR0630_44400	COG1376	ErfK ybiS ycfS ynhG family protein
RvVAR0630_44410	COG2818	Glycosylase
RvVAR0630_44460	COG0124	histidyl-tRNA synthetase
RvVAR0630_44480	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
RvVAR0630_44490	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
RvVAR0630_44510	COG0625	glutathione transferase activity
RvVAR0630_44530	COG0247	lactate metabolic process
RvVAR0630_44550	COG0277	FAD linked oxidase domain protein
RvVAR0630_44560	COG0277	FAD linked oxidase domain protein
RvVAR0630_44590	COG0306	phosphate transporter
RvVAR0630_44640	COG0583	DNA-binding transcription factor activity
RvVAR0630_44670	COG0583	DNA-binding transcription factor activity
RvVAR0630_44690	COG0412	Dienelactone hydrolase
RvVAR0630_44720	COG1609	Transcriptional regulator
RvVAR0630_44730	COG0395	ABC-type sugar transport system, permease component
RvVAR0630_44740	COG1175	transmembrane transport
RvVAR0630_44770	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
RvVAR0630_44800	COG1304	FMN binding
RvVAR0630_pl00040	COG0243	molybdopterin cofactor binding
RvVAR0630_pl00090	COG0395	ABC-type sugar transport system, permease component
RvVAR0630_pl00120	COG1309	transcriptional regulator
RvVAR0630_pl00140	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
RvVAR0630_pl00220	COG1940	carbohydrate kinase activity
RvVAR0630_pl00230	COG3842	ATPase activity
RvVAR0630_pl00240	COG1177	transmembrane transport
RvVAR0630_pl00290	COG3485	protocatechuate 3,4-dioxygenase
RvVAR0630_pl00410	COG0179	Fumarylacetoacetate (FAA) hydrolase
RvVAR0630_pl00450	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
RvVAR0630_pl00460	COG0179	Fumarylacetoacetate (FAA) hydrolase
RvVAR0630_pl00480	COG1028	Short-chain dehydrogenase reductase Sdr
RvVAR0630_pl00510	COG1960	acyl-CoA dehydrogenase activity
RvVAR0630_pl00520	COG2271	Major facilitator Superfamily
RvVAR0630_pl00540	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
RvVAR0630_pl00590	COG1414	Transcriptional regulator
RvVAR0630_pl00630	COG1960	acyl-CoA dehydrogenase activity
RvVAR0630_pl00650	COG1414	Transcriptional regulator
RvVAR0630_pl00670	COG3415	Transposase
RvVAR0630_pl00670	COG2801	Transposase and inactivated derivatives
RvVAR0630_pl00680	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
RvVAR0630_pl00780	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
RvVAR0630_pl00840	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
RvVAR0630_pl00860	COG1522	sequence-specific DNA binding
RvVAR0630_pl00870	COG3257	ureidoglycine aminohydrolase activity
RvVAR0630_pl00890	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
RvVAR0630_pl00910	COG1177	transmembrane transport
RvVAR0630_pl00930	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
RvVAR0630_pl00940	COG3842	ATPase activity
RvVAR0630_pl00980	COG2186	Transcriptional regulator
RvVAR0630_pl01000	COG3547	Transposase (IS116 IS110 IS902 family)
RvVAR0630_pl01050	COG2814	Major facilitator Superfamily
RvVAR0630_pl01060	COG4264	IucA IucC family
RvVAR0630_pl01070	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
RvVAR0630_pl01080	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
RvVAR0630_pl01090	COG0019	diaminopimelate decarboxylase activity
RvVAR0630_pl01100	COG1475	DNA binding
RvVAR0630_pl01260	COG1917	Cupin 2, conserved barrel domain protein
RvVAR0630_pl01260	COG4977	sequence-specific DNA binding
RvVAR0630_pl01280	COG3335	DDE superfamily endonuclease
RvVAR0630_pl01290	COG3415	Transposase
RvVAR0630_pl01400	COG2814	Major facilitator Superfamily
RvVAR0630_pl01410	COG0583	DNA-binding transcription factor activity
RvVAR0630_pl01430	COG4977	sequence-specific DNA binding
RvVAR0630_pl01510	COG3706	GGDEF domain
RvVAR0630_pl01520	COG2072	flavoprotein involved in K transport
RvVAR0630_pl01530	COG2072	flavoprotein involved in K transport
RvVAR0630_pl01540	COG0640	Transcriptional regulator
RvVAR0630_pl01550	COG1475	DNA binding
RvVAR0630_pl01560	COG1192	Involved in chromosome partitioning
RvVAR0630_pl01610	COG0765	amino acid transport
RvVAR0630_pl01640	COG1802	Transcriptional regulator
RvVAR0630_pl01660	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
RvVAR0630_pl01690	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
RvVAR0630_pl01700	COG1349	DNA-binding transcription factor activity
RvVAR0630_pl01710	COG4608	Belongs to the ABC transporter superfamily
RvVAR0630_pl01720	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RvVAR0630_pl01730	COG0601	transmembrane transport
RvVAR0630_pl01880	COG1120	ATPase activity
RvVAR0630_pl01890	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
RvVAR0630_pl01900	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
RvVAR0630_pl01910	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
RvVAR0630_pl01920	COG1629	transport
RvVAR0630_pl01920	COG4774	siderophore transport
RvVAR0630_pl02020	COG2226	methyltransferase
RvVAR0630_pl02050	COG0318	PFAM AMP-dependent synthetase and ligase
RvVAR0630_pl02090	COG0534	Mate efflux family protein
RvVAR0630_pl02140	COG0840	transmembrane signaling receptor activity
RvVAR0630_pl02170	COG1446	asparaginase
RvVAR0630_pl02180	COG2362	D-Aminopeptidase
RvVAR0630_pl02190	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RvVAR0630_pl02210	COG0747	negative chemotaxis
RvVAR0630_pl02220	COG4172	Belongs to the ABC transporter superfamily
RvVAR0630_pl02250	COG1940	carbohydrate kinase activity
RvVAR0630_pl02270	COG0395	ABC-type sugar transport system, permease component
RvVAR0630_pl02280	COG1175	transmembrane transport
RvVAR0630_pl02310	COG0110	maltose O-acetyltransferase activity
RvVAR0630_pl02350	COG3842	ATPase activity
RvVAR0630_pl02370	COG0395	ABC-type sugar transport system, permease component
RvVAR0630_pl02380	COG1175	transmembrane transport
RvVAR0630_pl02410	COG2186	Transcriptional regulator
RvVAR0630_pl02440	COG3842	ATPase activity
RvVAR0630_pl02460	COG1175	transmembrane transport
RvVAR0630_pl02470	COG0395	ABC-type sugar transport system, permease component
RvVAR0630_pl02490	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
RvVAR0630_pl02520	COG1129	ABC transporter
RvVAR0630_pl02530	COG1172	Belongs to the binding-protein-dependent transport system permease family
RvVAR0630_pl02540	COG1737	Transcriptional regulator
RvVAR0630_pl02570	COG3177	Filamentation induced by cAMP protein fic
RvVAR0630_pl02580	COG1069	ribulokinase activity
RvVAR0630_pl02610	COG2801	Transposase and inactivated derivatives
RvVAR0630_pl02610	COG3415	Transposase
RvVAR0630_pl02630	COG3547	Transposase (IS116 IS110 IS902 family)
RvVAR0630_pl02670	COG3938	Belongs to the proline racemase family
RvVAR0630_pl02680	COG4176	ABC-type proline glycine betaine transport system permease component
RvVAR0630_pl02690	COG4176	ABC-type proline glycine betaine transport system permease component
RvVAR0630_pl02700	COG3448	diguanylate cyclase activity
RvVAR0630_pl02700	COG4175	Glycine betaine
RvVAR0630_pl02720	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
RvVAR0630_pl02730	COG1012	belongs to the aldehyde dehydrogenase family
RvVAR0630_pl02740	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
RvVAR0630_pl02750	COG2186	Transcriptional regulator
RvVAR0630_pl02760	COG1802	Transcriptional regulator
RvVAR0630_pl02800	COG0583	DNA-binding transcription factor activity
RvVAR0630_pl02820	COG1573	uracil-dna glycosylase
RvVAR0630_pl02860	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
RvVAR0630_pl02900	COG1024	Enoyl-CoA hydratase
RvVAR0630_pl02910	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
RvVAR0630_pl02930	COG0318	PFAM AMP-dependent synthetase and ligase
RvVAR0630_pl02970	COG2124	cytochrome p450
RvVAR0630_pl03050	COG0277	FAD linked oxidase domain protein
RvVAR0630_pl03060	COG2181	nitrate reductase activity
RvVAR0630_pl03060	COG0247	lactate metabolic process
RvVAR0630_pl03120	COG1063	alcohol dehydrogenase
RvVAR0630_pl03130	COG3284	Transcriptional regulator
RvVAR0630_pl03190	COG3415	Transposase
RvVAR0630_pl03200	COG3335	DDE superfamily endonuclease
RvVAR0630_pl03220	COG5001	Diguanylate cyclase
RvVAR0630_pl03280	COG0662	Cupin 2, conserved barrel domain protein
RvVAR0630_pl03280	COG2207	Transcriptional regulator
RvVAR0630_pl03290	COG0243	molybdopterin cofactor binding
RvVAR0630_pl03300	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
RvVAR0630_pl03320	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
RvVAR0630_pl03330	COG1609	Transcriptional regulator
RvVAR0630_pl03360	COG1172	Belongs to the binding-protein-dependent transport system permease family
RvVAR0630_pl03370	COG1735	metal-dependent hydrolase with the TIM-barrel fold
RvVAR0630_pl03450	COG0745	RESPONSE REGULATOR receiver
RvVAR0630_pl03460	COG2205	protein histidine kinase activity
RvVAR0630_pl03530	COG2826	transposase and inactivated derivatives, IS30 family
RvVAR0630_pl03560	COG3415	Transposase
RvVAR0630_pl03560	COG2801	Transposase and inactivated derivatives
RvVAR0630_pl03680	COG2801	Transposase and inactivated derivatives
RvVAR0630_pl03680	COG3415	Transposase
RvVAR0630_pl03740	COG1172	Belongs to the binding-protein-dependent transport system permease family
RvVAR0630_pl03750	COG1129	ABC transporter
RvVAR0630_pl03760	COG1028	Short-chain dehydrogenase reductase Sdr
RvVAR0630_pl03870	COG3621	Patatin-like phospholipase
RvVAR0630_pl03880	COG1396	sequence-specific DNA binding
RvVAR0630_pl03910	COG3293	Transposase
RvVAR0630_pl03950	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
RvVAR0630_pl04000	COG3850	Histidine kinase
RvVAR0630_pl04000	COG4999	Histidine kinase
RvVAR0630_pl04000	COG2205	protein histidine kinase activity
RvVAR0630_pl04000	COG3437	response regulator, receiver
RvVAR0630_pl04010	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
RvVAR0630_pl04030	COG5002	protein histidine kinase activity
RvVAR0630_pl04060	COG2972	Histidine kinase
RvVAR0630_pl04060	COG0840	transmembrane signaling receptor activity
RvVAR0630_pl04080	COG3344	reverse transcriptase
RvVAR0630_pl04110	COG4251	negative regulation of phosphorylation
RvVAR0630_pl04140	COG0840	transmembrane signaling receptor activity
RvVAR0630_pl04210	COG0840	transmembrane signaling receptor activity
RvVAR0630_pl04260	COG5001	Diguanylate cyclase
RvVAR0630_pl04260	COG3300	MHYT domain
RvVAR0630_pl04270	COG1396	sequence-specific DNA binding
RvVAR0630_pl04380	COG4297	protein containing double-stranded beta helix domain
RvVAR0630_pl04580	COG1522	sequence-specific DNA binding
RvVAR0630_pl04760	COG0784	Response regulator, receiver
RvVAR0630_pl04760	COG4191	Histidine kinase
RvVAR0630_pl04830	COG4644	lycopene metabolic process
RvVAR0630_pl04890	COG2198	Histidine kinase
RvVAR0630_pl04890	COG0784	Response regulator, receiver
RvVAR0630_pl04890	COG2205	protein histidine kinase activity
RvVAR0630_pl04910	COG0643	Histidine kinase
RvVAR0630_pl04910	COG2198	Histidine kinase
RvVAR0630_pl04910	COG0784	Response regulator, receiver
RvVAR0630_pl04920	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
RvVAR0630_pl04930	COG2201	protein-glutamate methylesterase activity
RvVAR0630_pl04940	COG0835	chemotaxis
RvVAR0630_pl05000	COG2205	protein histidine kinase activity
RvVAR0630_pl05090	COG0776	regulation of translation
RvVAR0630_pl05100	COG1484	DNA-dependent DNA replication
RvVAR0630_pl05180	COG4644	lycopene metabolic process
RvVAR0630_pl05200	COG2801	Transposase and inactivated derivatives
RvVAR0630_pl05200	COG3415	Transposase
RvVAR0630_pl05210	COG0235	Class ii aldolase
RvVAR0630_pl05240	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
RvVAR0630_pl05340	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
RvVAR0630_pl05430	COG4644	lycopene metabolic process
RvVAR0630_pl05470	COG0640	Transcriptional regulator
RvVAR0630_pl05480	COG1475	DNA binding
RvVAR0630_pl05490	COG1192	Involved in chromosome partitioning
RvVAR0630_pl05510	COG4962	Type ii secretion system protein e
RvVAR0630_pl05540	COG3451	type IV secretory pathway VirB4
RvVAR0630_pl05550	COG5314	conjugation
RvVAR0630_pl05560	COG3846	protein secretion by the type IV secretion system
RvVAR0630_pl05570	COG3701	Conjugal transfer protein
RvVAR0630_pl05780	COG1475	DNA binding
RvVAR0630_pl05830	COG0300	oxidoreductase activity
RvVAR0630_pl05860	COG5489	Protein of unknown function (DUF736)
RvVAR0630_pl05870	COG0776	regulation of translation
RvVAR0630_pl05880	COG3831	ATPase activity
RvVAR0630_pl05980	COG2826	transposase and inactivated derivatives, IS30 family
RvVAR0630_pl06030	COG3547	Transposase (IS116 IS110 IS902 family)
RvVAR0630_pl06090	COG0667	Aldo Keto reductase
RvVAR0630_pl06110	COG1301	dicarboxylic acid transport
RvVAR0630_pl06130	COG2188	Transcriptional regulator
RvVAR0630_pl06140	COG3668	Plasmid stabilization system
RvVAR0630_pl06150	COG3609	addiction module antidote protein, CC2985 family
RvVAR0630_pl06200	COG0071	Belongs to the small heat shock protein (HSP20) family
RvVAR0630_pl06210	COG1942	4-Oxalocrotonate Tautomerase
RvVAR0630_pl06260	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
RvVAR0630_pl06320	COG1278	Cold shock
RvVAR0630_pl06410	COG1475	DNA binding
RvVAR0630_pl06450	COG0300	oxidoreductase activity
RvVAR0630_pl06480	COG5489	Protein of unknown function (DUF736)
RvVAR0630_pl06520	COG3831	ATPase activity
RvVAR0630_pl06570	COG3501	Rhs element vgr protein
RvVAR0630_pl06700	COG0137	argininosuccinate synthase activity
RvVAR0630_pl06730	COG2963	transposase activity
RvVAR0630_pl06750	COG4372	Transposase
RvVAR0630_pl06780	COG1396	sequence-specific DNA binding
RvVAR0630_pl06810	COG2207	Transcriptional regulator
RvVAR0630_pl06860	COG4598	ABC transporter
RvVAR0630_pl06890	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
RvVAR0630_pl06930	COG1609	Transcriptional regulator
RvVAR0630_pl06940	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
RvVAR0630_pl07020	COG1487	ribonuclease activity
RvVAR0630_pl07030	COG4691	Plasmid stability protein
RvVAR0630_pl07040	COG0640	Transcriptional regulator
RvVAR0630_pl07050	COG1475	DNA binding
RvVAR0630_pl07060	COG1192	Involved in chromosome partitioning
RvVAR0630_pl07080	COG0640	Transcriptional regulator
RvVAR0630_pl07090	COG1475	DNA binding
RvVAR0630_pl07100	COG1192	Involved in chromosome partitioning
RvVAR0630_pl07110	COG3831	ATPase activity
RvVAR0630_pl07150	COG0741	lytic transglycosylase activity
RvVAR0630_pl07150	COG0739	heme binding
RvVAR0630_pl07150	COG1196	nuclear chromosome segregation
RvVAR0630_pl07260	COG1609	Transcriptional regulator
RvVAR0630_pl07280	COG1175	transmembrane transport
RvVAR0630_pl07290	COG0395	ABC-type sugar transport system, permease component
RvVAR0630_pl07310	COG3842	ATPase activity
RvVAR0630_pl07320	COG3842	ATPase activity
RvVAR0630_pl07440	COG1192	Involved in chromosome partitioning
RvVAR0630_pl07490	COG1858	cytochrome C peroxidase
RvVAR0630_pl07510	COG0583	DNA-binding transcription factor activity
RvVAR0630_pl07590	COG0411	ABC transporter
RvVAR0630_pl07600	COG1172	Belongs to the binding-protein-dependent transport system permease family
RvVAR0630_pl07620	COG0154	amidase activity
RvVAR0630_pl07690	COG0747	negative chemotaxis
RvVAR0630_pl07730	COG4608	Belongs to the ABC transporter superfamily
RvVAR0630_pl07750	COG2423	ornithine cyclodeaminase activity
RvVAR0630_pl07800	COG1917	Cupin 2, conserved barrel domain protein
RvVAR0630_pl07800	COG2207	Transcriptional regulator
RvVAR0630_pl07810	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
RvVAR0630_pl07820	COG1136	(ABC) transporter
RvVAR0630_pl07880	COG1475	DNA binding
RvVAR0630_pl07940	COG2184	nucleotidyltransferase activity
RvVAR0630_pl07950	COG4227	nucleotidyltransferase activity
RvVAR0630_pl07960	COG1192	Involved in chromosome partitioning
RvVAR0630_pl07970	COG1475	DNA binding
RvVAR0630_pl07980	COG0640	Transcriptional regulator
RvVAR0630_pl08000	COG3706	GGDEF domain
RvVAR0630_pl08090	COG0515	serine threonine protein kinase
RvVAR0630_pl08090	COG2815	serine threonine protein kinase
RvVAR0630_pl08100	COG0515	serine threonine protein kinase
RvVAR0630_pl08200	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
RvVAR0630_pl08270	COG0741	lytic transglycosylase activity
RvVAR0630_pl08280	COG3451	type IV secretory pathway VirB4
RvVAR0630_pl08300	COG3838	Conjugal transfer protein Trbc
RvVAR0630_pl08310	COG0741	lytic transglycosylase activity
RvVAR0630_pl08390	COG1914	H( )-stimulated, divalent metal cation uptake system
RvVAR0630_pl08400	COG0789	Transcriptional regulator
RvVAR0630_pl08600	COG0789	Transcriptional regulator
RvVAR0630_pl08670	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
RvVAR0630_pl08850	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
RvVAR0630_pl09030	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
RvVAR0630_pl09100	COG5002	protein histidine kinase activity
RvVAR0630_pl09210	COG0789	Transcriptional regulator
RvVAR0630_pl09260	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family