locus-tag	class	description
MU522_00065	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
MU522_00080	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
MU522_00085	COG1162	GTPase activity
MU522_00090	COG0483	inositol monophosphate 1-phosphatase activity
MU522_00120	COG1012	belongs to the aldehyde dehydrogenase family
MU522_00135	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
MU522_00145	COG2884	Cell division ATP-binding protein ftsE
MU522_00155	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
MU522_00255	COG1002	Type II restriction enzyme, methylase subunits
MU522_00295	COG2267	carboxylic ester hydrolase activity
MU522_00305	COG1250	3-hydroxyacyl-CoA dehydrogenase
MU522_00310	COG1028	Short-chain dehydrogenase reductase Sdr
MU522_00325	COG1321	iron dependent repressor
MU522_00330	COG1108	ABC-type Mn2 Zn2 transport systems permease components
MU522_00335	COG1121	(ABC) transporter
MU522_00340	COG0803	Belongs to the bacterial solute-binding protein 9 family
MU522_00345	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
MU522_00350	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
MU522_00355	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
MU522_00365	COG1174	glycine betaine transport
MU522_00370	COG1174	glycine betaine transport
MU522_00400	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MU522_00410	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
MU522_00425	COG2226	methyltransferase
MU522_00435	COG1615	UPF0182 protein
MU522_00440	COG3480	Lon protease (S16) C-terminal proteolytic domain
MU522_00495	COG0513	Belongs to the DEAD box helicase family
MU522_00500	COG0613	PHP domain protein
MU522_00515	COG0006	proline dipeptidase activity
MU522_00525	COG0583	DNA-binding transcription factor activity
MU522_00535	COG2239	Acts as a magnesium transporter
MU522_00545	COG2151	metal-sulfur cluster biosynthetic enzyme
MU522_00545	COG0489	protein tyrosine kinase activity
MU522_00550	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
MU522_00555	COG4122	O-methyltransferase activity
MU522_00570	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
MU522_00575	COG2171	N-acyltransferase activity
MU522_00580	COG1131	(ABC) transporter
MU522_00590	COG2252	PERMEase
MU522_00610	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
MU522_00630	COG1217	gtp-binding protein TYPA
MU522_00645	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MU522_00670	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
MU522_00670	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
MU522_00675	COG0509	glycine decarboxylation via glycine cleavage system
MU522_00680	COG0404	The glycine cleavage system catalyzes the degradation of glycine
MU522_00685	COG1320	monovalent cation:proton antiporter activity
MU522_00700	COG0651	ATP synthesis coupled electron transport
MU522_00705	COG1006	Multisubunit Na H antiporter MnhC subunit
MU522_00710	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
MU522_00710	COG2111	Na H antiporter
MU522_00715	COG0420	3'-5' exonuclease activity
MU522_00720	COG0419	ATPase involved in DNA repair
MU522_00735	COG0477	Major facilitator Superfamily
MU522_00775	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
MU522_00835	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
MU522_00855	COG0488	(ABC) transporter
MU522_00865	COG2154	pterin-4-alpha-carbinolamine dehydratase
MU522_00895	COG1058	Belongs to the CinA family
MU522_00895	COG1546	Belongs to the CinA family
MU522_00905	COG0012	GTP binding
MU522_00915	COG1254	Belongs to the acylphosphatase family
MU522_00945	COG1181	Belongs to the D-alanine--D-alanine ligase family
MU522_00950	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
MU522_00960	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
MU522_00965	COG0066	3-isopropylmalate dehydratase activity
MU522_00970	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
MU522_00975	COG0598	Magnesium transport protein CorA
MU522_00980	COG0039	L-malate dehydrogenase activity
MU522_01030	COG0189	ligase activity
MU522_01030	COG4067	protein conserved in archaea
MU522_01035	COG0189	ligase activity
MU522_01035	COG0569	domain protein
MU522_01040	COG0477	Major facilitator Superfamily
MU522_01045	COG0179	Fumarylacetoacetate (FAA) hydrolase
MU522_01055	COG1012	belongs to the aldehyde dehydrogenase family
MU522_01065	COG3971	2-oxopent-4-enoate hydratase activity
MU522_01075	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MU522_01085	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
MU522_01100	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
MU522_01105	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MU522_01145	COG0492	ferredoxin-NADP+ reductase activity
MU522_01150	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
MU522_01170	COG0179	Fumarylacetoacetate (FAA) hydrolase
MU522_01175	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
MU522_01180	COG0473	3-isopropylmalate dehydrogenase activity
MU522_01190	COG0477	Major facilitator Superfamily
MU522_01230	COG1840	ABC-type Fe3 transport system, periplasmic component
MU522_01240	COG3842	ATPase activity
MU522_01245	COG2801	Transposase and inactivated derivatives
MU522_01245	COG3415	Transposase
MU522_01255	COG0723	plastoquinol--plastocyanin reductase activity
MU522_01260	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
MU522_01265	COG0440	acetolactate synthase activity
MU522_01270	COG0028	Belongs to the TPP enzyme family
MU522_01275	COG0129	dihydroxy-acid dehydratase activity
MU522_01280	COG1082	Xylose isomerase domain protein TIM barrel
MU522_01290	COG0318	PFAM AMP-dependent synthetase and ligase
MU522_01305	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
MU522_01315	COG2409	Drug exporters of the RND superfamily
MU522_01410	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
MU522_01420	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
MU522_01425	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
MU522_01435	COG3214	Protein conserved in bacteria
MU522_01475	COG0148	phosphopyruvate hydratase activity
MU522_01480	COG0124	histidyl-tRNA synthetase
MU522_01495	COG2130	NADP-dependent
MU522_01500	COG3956	TIGRFAM MazG family protein
MU522_01515	COG0193	aminoacyl-tRNA hydrolase activity
MU522_01520	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
MU522_01525	COG2610	gluconate transmembrane transporter activity
MU522_01530	COG3265	gluconokinase activity
MU522_01540	COG1028	Short-chain dehydrogenase reductase Sdr
MU522_01550	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MU522_01565	COG0686	Belongs to the AlaDH PNT family
MU522_01575	COG0668	transmembrane transport
MU522_01580	COG4565	transcriptional regulatory protein
MU522_01585	COG3290	protein histidine kinase activity
MU522_01590	COG1301	dicarboxylic acid transport
MU522_01600	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
MU522_01610	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
MU522_01615	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
MU522_01645	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
MU522_01660	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
MU522_01695	COG1482	cell wall glycoprotein biosynthetic process
MU522_01700	COG1960	acyl-CoA dehydrogenase activity
MU522_01705	COG1216	Glycosyl transferase, family 2
MU522_01815	COG0438	transferase activity, transferring glycosyl groups
MU522_01820	COG1316	TRANSCRIPTIONal
MU522_01825	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
MU522_01835	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
MU522_01850	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
MU522_01865	COG2755	lipolytic protein G-D-S-L family
MU522_01865	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
MU522_01880	COG0039	L-malate dehydrogenase activity
MU522_01885	COG0424	maF-like protein
MU522_01910	COG4770	biotin carboxylase activity
MU522_01940	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
MU522_01945	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
MU522_01950	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
MU522_01955	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
MU522_01970	COG1079	Belongs to the binding-protein-dependent transport system permease family
MU522_01975	COG4603	Belongs to the binding-protein-dependent transport system permease family
MU522_01980	COG3845	ABC transporter
MU522_01985	COG1744	ABC transporter substrate-binding protein PnrA-like
MU522_01990	COG1744	ABC transporter substrate-binding protein PnrA-like
MU522_02000	COG0438	transferase activity, transferring glycosyl groups
MU522_02005	COG2009	succinate dehydrogenase
MU522_02020	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
MU522_02040	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
MU522_02055	COG0180	Tryptophanyl-tRNA synthetase
MU522_02065	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
MU522_02070	COG0321	lipoyl(octanoyl) transferase activity
MU522_02095	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
MU522_02100	COG0477	Major facilitator Superfamily
MU522_02105	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
MU522_02130	COG1132	(ABC) transporter
MU522_02145	COG2409	Drug exporters of the RND superfamily
MU522_02150	COG1335	isochorismatase
MU522_02170	COG0463	Glycosyl transferase, family 2
MU522_02220	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
MU522_02230	COG0470	DNA polymerase III
MU522_02235	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
MU522_02275	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
MU522_02290	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
MU522_02305	COG1435	thymidine kinase activity
MU522_02315	COG0579	oxidoreductase
MU522_02335	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
MU522_02360	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
MU522_02390	COG2801	Transposase and inactivated derivatives
MU522_02390	COG3415	Transposase
MU522_02395	COG3415	Transposase
MU522_02395	COG2801	Transposase and inactivated derivatives
MU522_02400	COG0745	RESPONSE REGULATOR receiver
MU522_02415	COG5002	protein histidine kinase activity
MU522_02420	COG0433	COG0433 Predicted ATPase
MU522_02430	COG1228	amidohydrolase
MU522_02435	COG4214	carbohydrate transport
MU522_02445	COG4213	ABC transporter substrate-binding protein
MU522_02450	COG2160	L-arabinose isomerase activity
MU522_02465	COG1609	Transcriptional regulator
MU522_02475	COG0477	Major facilitator Superfamily
MU522_02480	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
MU522_02485	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
MU522_02495	COG1349	DNA-binding transcription factor activity
MU522_02515	COG1132	(ABC) transporter
MU522_02520	COG0222	ribosome binding
MU522_02525	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
MU522_02535	COG2205	protein histidine kinase activity
MU522_02540	COG0745	RESPONSE REGULATOR receiver
MU522_02570	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MU522_02575	COG0601	transmembrane transport
MU522_02580	COG0747	negative chemotaxis
MU522_02585	COG0081	regulation of translation
MU522_02590	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
MU522_02600	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
MU522_02610	COG0436	Aminotransferase
MU522_02615	COG1131	(ABC) transporter
MU522_02635	COG0812	UDP-N-acetylmuramate dehydrogenase activity
MU522_02645	COG2030	dehydratase
MU522_02675	COG0366	Alpha amylase catalytic
MU522_02685	COG0733	neurotransmitter:sodium symporter activity
MU522_02690	COG3833	ABC-type maltose transport systems, permease component
MU522_02695	COG1175	transmembrane transport
MU522_02705	COG0366	Alpha amylase catalytic
MU522_02710	COG1196	nuclear chromosome segregation
MU522_02710	COG0741	lytic transglycosylase activity
MU522_02710	COG0739	heme binding
MU522_02725	COG1666	GTP binding
MU522_02730	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
MU522_02745	COG0142	geranyltranstransferase activity
MU522_02750	COG2226	methyltransferase
MU522_02760	COG2326	polyphosphate kinase activity
MU522_02765	COG0628	permease
MU522_02770	COG0300	oxidoreductase activity
MU522_02775	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
MU522_02805	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
MU522_02835	COG4948	Mandelate Racemase Muconate Lactonizing
MU522_02845	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
MU522_02850	COG1333	cytochrome c biogenesis protein
MU522_02855	COG0785	Cytochrome C biogenesis protein
MU522_02865	COG0406	alpha-ribazole phosphatase activity
MU522_02875	COG0017	Asparaginyl-tRNA synthetase
MU522_02895	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
MU522_02900	COG0569	domain protein
MU522_02905	COG3012	SEC-C Motif Domain Protein
MU522_02930	COG0590	tRNA wobble adenosine to inosine editing
MU522_02935	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
MU522_02970	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
MU522_02980	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
MU522_02985	COG0588	phosphoglycerate mutase activity
MU522_02990	COG0277	FAD linked oxidase domain protein
MU522_03005	COG1966	Carbon starvation protein
MU522_03025	COG1278	Cold shock
MU522_03030	COG0860	N-Acetylmuramoyl-L-alanine amidase
MU522_03030	COG2247	cell wall binding repeat
MU522_03040	COG4106	trans-aconitate 2-methyltransferase activity
MU522_03055	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MU522_03060	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
MU522_03075	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MU522_03085	COG1316	TRANSCRIPTIONal
MU522_03095	COG0561	phosphatase activity
MU522_03100	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
MU522_03105	COG1597	lipid kinase activity
MU522_03110	COG0425	Belongs to the sulfur carrier protein TusA family
MU522_03115	COG2391	methyltransferase activity
MU522_03120	COG0077	Prephenate dehydratase
MU522_03130	COG0033	Phosphoglucomutase
MU522_03145	COG1876	peptidase activity
MU522_03150	COG0477	Major facilitator Superfamily
MU522_03175	COG0514	ATP-dependent DNA helicase (RecQ)
MU522_03180	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
MU522_03195	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
MU522_03200	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
MU522_03205	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
MU522_03215	COG1760	l-serine dehydratase
MU522_03235	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
MU522_03240	COG1063	alcohol dehydrogenase
MU522_03250	COG1028	Short-chain dehydrogenase reductase Sdr
MU522_03270	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
MU522_03275	COG2031	fatty acid transporter
MU522_03290	COG0151	Belongs to the GarS family
MU522_03295	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
MU522_03305	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
MU522_03310	COG0047	phosphoribosylformylglycinamidine synthase activity
MU522_03320	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
MU522_03350	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
MU522_03355	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
MU522_03380	COG0137	argininosuccinate synthase activity
MU522_03390	COG4941	Belongs to the sigma-70 factor family
MU522_03410	COG1201	RNA secondary structure unwinding
MU522_03415	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
MU522_03445	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
MU522_03475	COG1819	glycosyl
MU522_03480	COG1819	glycosyl
MU522_03495	COG4221	oxidoreductase activity
MU522_03510	COG1569	PIN domain
MU522_03515	COG3311	Transcriptional regulator
MU522_03535	COG5416	Lipopolysaccharide assembly protein A domain
MU522_03545	COG1362	aminopeptidase activity
MU522_03560	COG1476	TRANSCRIPTIONal
MU522_03570	COG0659	secondary active sulfate transmembrane transporter activity
MU522_03580	COG1113	amino acid transport
MU522_03595	COG0494	nUDIX hydrolase
MU522_03605	COG2011	ABC-type metal ion transport system permease component
MU522_03640	COG0860	N-Acetylmuramoyl-L-alanine amidase
MU522_03640	COG2247	cell wall binding repeat
MU522_03650	COG0415	Belongs to the DNA photolyase family
MU522_03690	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
MU522_03700	COG1940	carbohydrate kinase activity
MU522_03705	COG0513	Belongs to the DEAD box helicase family
MU522_03715	COG2814	Major facilitator Superfamily
MU522_03720	COG0542	response to heat
MU522_03740	COG0596	Alpha beta hydrolase
MU522_03750	COG2205	protein histidine kinase activity
MU522_03770	COG0071	Belongs to the small heat shock protein (HSP20) family
MU522_03785	COG0789	Transcriptional regulator
MU522_03790	COG0484	heat shock protein binding
MU522_03800	COG0443	Heat shock 70 kDa protein
MU522_03805	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
MU522_03805	COG0475	glutathione-regulated potassium exporter activity
MU522_03845	COG0717	Belongs to the dCTP deaminase family
MU522_03885	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
MU522_03890	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
MU522_03900	COG1960	acyl-CoA dehydrogenase activity
MU522_03920	COG1024	Enoyl-CoA hydratase
MU522_03925	COG1250	3-hydroxyacyl-CoA dehydrogenase
MU522_03930	COG2030	dehydratase
MU522_03930	COG1012	belongs to the aldehyde dehydrogenase family
MU522_03955	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MU522_03965	COG0747	negative chemotaxis
MU522_03985	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
MU522_03990	COG2050	protein possibly involved in aromatic compounds catabolism
MU522_03995	COG3396	Phenylacetate-CoA oxygenase
MU522_04000	COG3460	Phenylacetate-CoA oxygenase
MU522_04005	COG3396	Phenylacetate-CoA oxygenase
MU522_04010	COG2151	metal-sulfur cluster biosynthetic enzyme
MU522_04015	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
MU522_04060	COG2264	protein methyltransferase activity
MU522_04065	COG0542	response to heat
MU522_04080	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MU522_04085	COG0693	protein deglycase activity
MU522_04100	COG1780	Probably involved in ribonucleotide reductase function
MU522_04105	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
MU522_04110	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
MU522_04125	COG2442	InterPro IPR007367
MU522_04140	COG3842	ATPase activity
MU522_04145	COG1178	ABC-type Fe3 transport system permease component
MU522_04160	COG2066	Belongs to the glutaminase family
MU522_04175	COG3655	Transcriptional regulator
MU522_04205	COG1322	Protein conserved in bacteria
MU522_04225	COG0702	epimerase
MU522_04255	COG0142	geranyltranstransferase activity
MU522_04270	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
MU522_04295	COG3590	peptidase
MU522_04300	COG0534	Mate efflux family protein
MU522_04305	COG3559	Exporter of polyketide antibiotics
MU522_04310	COG1131	(ABC) transporter
MU522_04315	COG0738	Major facilitator superfamily
MU522_04320	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
MU522_04330	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
MU522_04335	COG0113	porphobilinogen synthase activity
MU522_04345	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
MU522_04350	COG0488	(ABC) transporter
MU522_04365	COG0181	hydroxymethylbilane synthase activity
MU522_04370	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
MU522_04380	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
MU522_04385	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
MU522_04390	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
MU522_04405	COG0395	ABC-type sugar transport system, permease component
MU522_04410	COG1175	transmembrane transport
MU522_04430	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
MU522_04435	COG0395	ABC-type sugar transport system, permease component
MU522_04440	COG1175	transmembrane transport
MU522_04445	COG1653	transport
MU522_04450	COG1609	Transcriptional regulator
MU522_04455	COG0366	Alpha amylase catalytic
MU522_04510	COG0006	proline dipeptidase activity
MU522_04515	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
MU522_04540	COG1716	ATPase activity
MU522_04560	COG0515	serine threonine protein kinase
MU522_04580	COG3764	Sortase (surface protein transpeptidase)
MU522_04590	COG0705	Rhomboid family
MU522_04615	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
MU522_04650	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
MU522_04655	COG0187	DNA topoisomerase II activity
MU522_04660	COG2084	Dehydrogenase
MU522_04670	COG1802	Transcriptional regulator
MU522_04675	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
MU522_04680	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
MU522_04685	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
MU522_04690	COG0592	DNA-directed DNA polymerase activity
MU522_04695	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
MU522_04700	COG0230	Belongs to the bacterial ribosomal protein bL34 family
MU522_04705	COG0594	ribonuclease P activity
MU522_04710	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
MU522_04715	COG0706	membrane insertase activity
MU522_04725	COG0357	Ribosomal RNA small subunit methyltransferase G
MU522_04730	COG1192	Involved in chromosome partitioning
MU522_04740	COG3118	belongs to the thioredoxin family
MU522_04755	COG0728	peptidoglycan biosynthetic process
MU522_04765	COG0617	tRNA 3'-terminal CCA addition
MU522_04770	COG0360	Binds together with S18 to 16S ribosomal RNA
MU522_04780	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
MU522_04785	COG0359	binds to the 23S rRNA
MU522_04815	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
MU522_04850	COG2897	thiosulfate sulfurtransferase activity
MU522_04860	COG0753	catalase activity
MU522_04870	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
MU522_04875	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
MU522_04890	COG1950	PFAM Membrane protein of
MU522_04895	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
MU522_04905	COG0022	dehydrogenase e1 component
MU522_04910	COG0508	dehydrogenase complex catalyzes the overall conversion of
MU522_04925	COG1121	(ABC) transporter
MU522_04930	COG1108	ABC-type Mn2 Zn2 transport systems permease components
MU522_04950	COG0227	Belongs to the bacterial ribosomal protein bL28 family
MU522_04955	COG0267	Belongs to the bacterial ribosomal protein bL33 family
MU522_04960	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
MU522_04980	COG2364	Membrane
MU522_05000	COG0406	alpha-ribazole phosphatase activity
MU522_05010	COG0730	response to heat
MU522_05030	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
MU522_05040	COG1648	precorrin-2 dehydrogenase activity
MU522_05040	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
MU522_05055	COG1054	Belongs to the UPF0176 family
MU522_05070	COG1012	belongs to the aldehyde dehydrogenase family
MU522_05075	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MU522_05085	COG1136	(ABC) transporter
MU522_05110	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
MU522_05135	COG2801	Transposase and inactivated derivatives
MU522_05135	COG3415	Transposase
MU522_05150	COG1834	amidinotransferase
MU522_05180	COG0438	transferase activity, transferring glycosyl groups
MU522_05185	COG1070	Carbohydrate kinase
MU522_05195	COG1129	ABC transporter
MU522_05200	COG1172	Belongs to the binding-protein-dependent transport system permease family
MU522_05220	COG0800	Aldolase
MU522_05240	COG2188	Transcriptional regulator
MU522_05245	COG1869	D-ribose catabolic process
MU522_05250	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MU522_05255	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
MU522_05260	COG1028	Short-chain dehydrogenase reductase Sdr
MU522_05265	COG0179	Fumarylacetoacetate (FAA) hydrolase
MU522_05270	COG4948	Mandelate Racemase Muconate Lactonizing
MU522_05285	COG4154	Belongs to the RbsD FucU family
MU522_05290	COG2186	Transcriptional regulator
MU522_05300	COG0823	Involved in the tonB-independent uptake of proteins
MU522_05300	COG1506	peptidase
MU522_05305	COG2610	gluconate transmembrane transporter activity
MU522_05310	COG2084	Dehydrogenase
MU522_05315	COG1082	Xylose isomerase domain protein TIM barrel
MU522_05335	COG1305	Transglutaminase-like
MU522_05375	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
MU522_05380	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
MU522_05390	COG2084	Dehydrogenase
MU522_05405	COG1028	Short-chain dehydrogenase reductase Sdr
MU522_05410	COG2188	Transcriptional regulator
MU522_05425	COG3550	peptidyl-serine autophosphorylation
MU522_05430	COG3958	Transketolase
MU522_05435	COG3959	Transketolase, thiamine diphosphate binding domain
MU522_05440	COG2084	Dehydrogenase
MU522_05445	COG2186	Transcriptional regulator
MU522_05490	COG0235	Class ii aldolase
MU522_05505	COG1028	Short-chain dehydrogenase reductase Sdr
MU522_05505	COG3347	Dehydrogenase
MU522_05510	COG2188	Transcriptional regulator
MU522_05515	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
MU522_05515	COG0235	Class ii aldolase
MU522_05525	COG1129	ABC transporter
MU522_05535	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
MU522_05585	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
MU522_05630	COG1454	alcohol dehydrogenase
MU522_05680	COG0477	Major facilitator Superfamily
MU522_05685	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MU522_05695	COG0640	Transcriptional regulator
MU522_05720	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
MU522_05745	COG3832	glyoxalase III activity
MU522_05750	COG0640	Transcriptional regulator
MU522_05780	COG0386	Belongs to the glutathione peroxidase family
MU522_05785	COG0183	Belongs to the thiolase family
MU522_05800	COG1960	acyl-CoA dehydrogenase activity
MU522_05820	COG2086	electron transfer activity
MU522_05825	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
MU522_05840	COG0730	response to heat
MU522_05850	COG2814	Major facilitator Superfamily
MU522_05870	COG2205	protein histidine kinase activity
MU522_05895	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MU522_05910	COG0477	Major facilitator Superfamily
MU522_05915	COG2233	PERMEase
MU522_05920	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
MU522_05935	COG2267	carboxylic ester hydrolase activity
MU522_05950	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
MU522_05955	COG0402	S-adenosylhomocysteine deaminase activity
MU522_05960	COG0861	Integral membrane protein TerC family
MU522_05995	COG1802	Transcriptional regulator
MU522_06050	COG3938	Belongs to the proline racemase family
MU522_06060	COG3938	Belongs to the proline racemase family
MU522_06070	COG1131	(ABC) transporter
MU522_06110	COG4977	sequence-specific DNA binding
MU522_06195	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
MU522_06200	COG0037	tRNA processing
MU522_06220	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MU522_06225	COG0302	gtp cyclohydrolase
MU522_06235	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
MU522_06245	COG1316	TRANSCRIPTIONal
MU522_06265	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
MU522_06270	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
MU522_06290	COG3655	Transcriptional regulator
MU522_06330	COG0741	lytic transglycosylase activity
MU522_06330	COG1196	nuclear chromosome segregation
MU522_06330	COG0739	heme binding
MU522_06355	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
MU522_06420	COG0667	Aldo Keto reductase
MU522_06450	COG0085	RNA polymerase activity
MU522_06455	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
MU522_06470	COG0714	Associated with various cellular activities
MU522_06490	COG0631	protein serine/threonine phosphatase activity
MU522_06500	COG0515	serine threonine protein kinase
MU522_06500	COG2815	serine threonine protein kinase
MU522_06565	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
MU522_06570	COG0049	tRNA binding
MU522_06575	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
MU522_06580	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
MU522_06615	COG1414	Transcriptional regulator
MU522_06620	COG2986	histidine ammonia-lyase
MU522_06625	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
MU522_06630	COG1228	amidohydrolase
MU522_06640	COG2201	protein-glutamate methylesterase activity
MU522_06660	COG0051	transcription antitermination factor activity, RNA binding
MU522_06665	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
MU522_06670	COG0088	Forms part of the polypeptide exit tunnel
MU522_06675	COG0089	rRNA binding
MU522_06680	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
MU522_06685	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
MU522_06690	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
MU522_06695	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
MU522_06700	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
MU522_06705	COG0255	Belongs to the universal ribosomal protein uL29 family
MU522_06710	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
MU522_06715	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
MU522_06720	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
MU522_06725	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
MU522_06730	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
MU522_06735	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
MU522_06740	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
MU522_06745	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
MU522_06750	COG1841	ribosomal large subunit assembly
MU522_06755	COG0200	Binds to the 23S rRNA
MU522_06765	COG0563	adenylate kinase activity
MU522_06770	COG0024	Methionine aminopeptidase
MU522_06785	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
MU522_06790	COG0246	Mannitol dehydrogenase
MU522_06795	COG2217	Heavy metal translocating P-type atpase
MU522_06805	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
MU522_06810	COG0257	Belongs to the bacterial ribosomal protein bL36 family
MU522_06815	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
MU522_06820	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
MU522_06825	COG0202	RNA polymerase activity
MU522_06830	COG0203	ribosomal protein L17
MU522_06835	COG3387	PFAM Glycoside hydrolase 15-related
MU522_06840	COG0101	tRNA pseudouridine synthase activity
MU522_06855	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
MU522_06860	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
MU522_06865	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
MU522_06880	COG1072	(Pantothenic acid kinase))
MU522_06885	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
MU522_06890	COG0736	holo-[acyl-carrier-protein] synthase activity
MU522_06895	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
MU522_06910	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
MU522_06930	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
MU522_06990	COG0516	GMP reductase activity
MU522_06995	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
MU522_07010	COG0518	GMP synthase (glutamine-hydrolyzing) activity
MU522_07010	COG0519	Catalyzes the synthesis of GMP from XMP
MU522_07030	COG4941	Belongs to the sigma-70 factor family
MU522_07040	COG0822	iron-sulfur transferase activity
MU522_07045	COG0385	Bile acid
MU522_07060	COG0584	glycerophosphoryl diester phosphodiesterase
MU522_07100	COG3290	protein histidine kinase activity
MU522_07115	COG0045	succinate-CoA ligase (ADP-forming) activity
MU522_07135	COG2838	Isocitrate dehydrogenase
MU522_07150	COG0138	bifunctional purine biosynthesis protein purh
MU522_07160	COG1132	(ABC) transporter
MU522_07165	COG1132	(ABC) transporter
MU522_07190	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
MU522_07195	COG0587	DNA-directed DNA polymerase activity
MU522_07215	COG2814	Major facilitator Superfamily
MU522_07225	COG1012	belongs to the aldehyde dehydrogenase family
MU522_07240	COG1028	Short-chain dehydrogenase reductase Sdr
MU522_07245	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
MU522_07250	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
MU522_07290	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
MU522_07305	COG2017	converts alpha-aldose to the beta-anomer
MU522_07370	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
MU522_07390	COG1063	alcohol dehydrogenase
MU522_07450	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
MU522_07465	COG0494	nUDIX hydrolase
MU522_07465	COG0406	alpha-ribazole phosphatase activity
MU522_07470	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
MU522_07475	COG0456	acetyltransferase
MU522_07475	COG0454	-acetyltransferase
MU522_07480	COG0745	RESPONSE REGULATOR receiver
MU522_07490	COG4044	May play a role in the intracellular transport of hydrophobic ligands
MU522_07495	COG0354	folic acid binding
MU522_07510	COG0588	phosphoglycerate mutase activity
MU522_07515	COG0704	Plays a role in the regulation of phosphate uptake
MU522_07520	COG5002	protein histidine kinase activity
MU522_07525	COG0745	RESPONSE REGULATOR receiver
MU522_07535	COG1329	Transcriptional regulator
MU522_07540	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
MU522_07540	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
MU522_07545	COG0215	cysteine-tRNA ligase activity
MU522_07550	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
MU522_07560	COG3842	ATPase activity
MU522_07585	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
MU522_07600	COG0459	protein refolding
MU522_07610	COG2205	protein histidine kinase activity
MU522_07615	COG0745	RESPONSE REGULATOR receiver
MU522_07620	COG1061	Type III restriction enzyme res subunit
MU522_07635	COG1278	Cold shock
MU522_07645	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
MU522_07655	COG0791	NLP P60 protein
MU522_07665	COG2217	Heavy metal translocating P-type atpase
MU522_07720	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
MU522_07780	COG0671	phosphoesterase, PA-phosphatase related
MU522_07810	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
MU522_07815	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
MU522_07830	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
MU522_07840	COG0110	maltose O-acetyltransferase activity
MU522_07885	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
MU522_07890	COG1134	teichoic acid transport
MU522_07900	COG0438	transferase activity, transferring glycosyl groups
MU522_07905	COG1210	Utp--glucose-1-phosphate uridylyltransferase
MU522_07930	COG3281	Trehalose synthase
MU522_07950	COG0656	L-ascorbic acid biosynthetic process
MU522_07980	COG1643	Atp-dependent helicase
MU522_07990	COG0662	Cupin 2, conserved barrel domain protein
MU522_08010	COG1061	Type III restriction enzyme res subunit
MU522_08035	COG2079	MmgE PrpD family protein
MU522_08040	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
MU522_08045	COG1902	pentaerythritol trinitrate reductase activity
MU522_08050	COG1960	acyl-CoA dehydrogenase activity
MU522_08055	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
MU522_08075	COG1331	Highly conserved protein containing a thioredoxin domain
MU522_08090	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MU522_08105	COG0084	hydrolase, TatD family'
MU522_08115	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
MU522_08125	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
MU522_08130	COG0488	(ABC) transporter
MU522_08145	COG0745	RESPONSE REGULATOR receiver
MU522_08150	COG5002	protein histidine kinase activity
MU522_08155	COG5401	PFAM Sporulation and spore germination
MU522_08165	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
MU522_08170	COG0653	protein targeting
MU522_08190	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
MU522_08235	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
MU522_08240	COG2011	ABC-type metal ion transport system permease component
MU522_08250	COG1505	serine-type exopeptidase activity
MU522_08265	COG0114	fumarate hydratase activity
MU522_08275	COG1722	exodeoxyribonuclease VII activity
MU522_08280	COG1570	exodeoxyribonuclease VII activity
MU522_08285	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
MU522_08300	COG0191	fructose-bisphosphate aldolase activity
MU522_08305	COG2376	Dihydroxyacetone kinase
MU522_08310	COG0698	ribose 5-phosphate isomerase
MU522_08315	COG0149	triose-phosphate isomerase activity
MU522_08335	COG1028	Short-chain dehydrogenase reductase Sdr
MU522_08340	COG2271	Major facilitator Superfamily
MU522_08345	COG1494	fructose-1,6-bisphosphatase
MU522_08385	COG0318	PFAM AMP-dependent synthetase and ligase
MU522_08395	COG1028	Short-chain dehydrogenase reductase Sdr
MU522_08400	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
MU522_08425	COG4176	ABC-type proline glycine betaine transport system permease component
MU522_08430	COG3448	diguanylate cyclase activity
MU522_08430	COG4175	Glycine betaine
MU522_08455	COG0742	ribosomal rna small subunit methyltransferase
MU522_08465	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
MU522_08470	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
MU522_08470	COG0778	Nitroreductase
MU522_08475	COG0714	Associated with various cellular activities
MU522_08490	COG1920	GTP binding
MU522_08500	COG1120	ATPase activity
MU522_08505	COG4139	cobalamin transport
MU522_08515	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
MU522_08525	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
MU522_08550	COG0154	amidase activity
MU522_08560	COG0297	glycogen (starch) synthase activity
MU522_08565	COG1024	Enoyl-CoA hydratase
MU522_08570	COG1842	Phage shock protein A
MU522_08600	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
MU522_08625	COG1937	Protein conserved in bacteria
MU522_08675	COG2894	cell division
MU522_08705	COG0018	arginyl-trna synthetase
MU522_08710	COG2094	Belongs to the DNA glycosylase MPG family
MU522_08715	COG0019	diaminopimelate decarboxylase activity
MU522_08720	COG0460	homoserine dehydrogenase
MU522_08725	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
MU522_08730	COG0083	homoserine kinase activity
MU522_08740	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
MU522_08770	COG2076	Multidrug Resistance protein
MU522_08775	COG1045	serine acetyltransferase
MU522_08805	COG0356	it plays a direct role in the translocation of protons across the membrane
MU522_08810	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
MU522_08815	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
MU522_08820	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
MU522_08825	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
MU522_08830	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
MU522_08835	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
MU522_08840	COG0355	proton-transporting ATP synthase activity, rotational mechanism
MU522_08845	COG3022	response to hydroperoxide
MU522_08850	COG0514	ATP-dependent DNA helicase (RecQ)
MU522_08855	COG1403	HNH endonuclease
MU522_08865	COG0667	Aldo Keto reductase
MU522_08870	COG1316	TRANSCRIPTIONal
MU522_08875	COG1316	TRANSCRIPTIONal
MU522_08880	COG0405	Gamma-glutamyltransferase
MU522_08885	COG2217	Heavy metal translocating P-type atpase
MU522_08900	COG0631	protein serine/threonine phosphatase activity
MU522_08905	COG0515	serine threonine protein kinase
MU522_08905	COG2815	serine threonine protein kinase
MU522_08915	COG0714	Associated with various cellular activities
MU522_08935	COG0686	Belongs to the AlaDH PNT family
MU522_08950	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
MU522_08965	COG0750	zinc metalloprotease
MU522_08975	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
MU522_08980	COG2814	Major facilitator Superfamily
MU522_08985	COG0714	Associated with various cellular activities
MU522_09015	COG0442	prolyl-tRNA aminoacylation
MU522_09020	COG1115	amino acid carrier protein
MU522_09030	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
MU522_09030	COG3266	domain, Protein
MU522_09035	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
MU522_09040	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
MU522_09055	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
MU522_09060	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
MU522_09080	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
MU522_09085	COG1012	belongs to the aldehyde dehydrogenase family
MU522_09090	COG1012	belongs to the aldehyde dehydrogenase family
MU522_09105	COG3483	tryptophan 2,3-dioxygenase activity
MU522_09135	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
MU522_09145	COG1185	polyribonucleotide nucleotidyltransferase activity
MU522_09150	COG0612	Peptidase, M16
MU522_09155	COG0588	phosphoglycerate mutase activity
MU522_09165	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
MU522_09175	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
MU522_09190	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
MU522_09195	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
MU522_09200	COG1674	ftsk spoiiie
MU522_09210	COG1546	Belongs to the CinA family
MU522_09210	COG1058	Belongs to the CinA family
MU522_09215	COG1396	sequence-specific DNA binding
MU522_09225	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
MU522_09240	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
MU522_09245	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
MU522_09250	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
MU522_09255	COG2813	Specifically methylates the guanine in position
MU522_09260	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
MU522_09265	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
MU522_09275	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
MU522_09280	COG0131	Imidazoleglycerol-phosphate dehydratase
MU522_09285	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
MU522_09290	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
MU522_09305	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
MU522_09310	COG0291	Belongs to the bacterial ribosomal protein bL35 family
MU522_09315	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
MU522_09320	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
MU522_09325	COG1126	abc transporter atp-binding protein
MU522_09330	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MU522_09335	COG0765	amino acid transport
MU522_09340	COG0765	amino acid transport
MU522_09345	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
MU522_09350	COG0072	phenylalanine-tRNA ligase activity
MU522_09350	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MU522_09360	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
MU522_09365	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
MU522_09370	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
MU522_09375	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
MU522_09380	COG0165	Argininosuccinate lyase
MU522_09385	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
MU522_09430	COG1011	Hydrolase
MU522_09455	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
MU522_09460	COG0497	DNA recombination
MU522_09465	COG0504	CTP synthase activity
MU522_09470	COG0494	nUDIX hydrolase
MU522_09485	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
MU522_09490	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
MU522_09505	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
MU522_09510	COG1160	GTP binding
MU522_09515	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
MU522_09525	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
MU522_09530	COG2814	Major facilitator Superfamily
MU522_09535	COG2375	cellular response to nickel ion
MU522_09570	COG2133	pyrroloquinoline quinone binding
MU522_09585	COG2205	protein histidine kinase activity
MU522_09590	COG0626	cystathionine gamma-synthase activity
MU522_09600	COG0446	pyridine nucleotide-disulphide oxidoreductase
MU522_09600	COG1902	pentaerythritol trinitrate reductase activity
MU522_09615	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
MU522_09620	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
MU522_09625	COG0183	Belongs to the thiolase family
MU522_09630	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MU522_09640	COG1929	Belongs to the glycerate kinase type-1 family
MU522_09645	COG0518	GMP synthase (glutamine-hydrolyzing) activity
MU522_09645	COG0519	Catalyzes the synthesis of GMP from XMP
MU522_09650	COG2818	Glycosylase
MU522_09665	COG1716	ATPase activity
MU522_09680	COG1192	Involved in chromosome partitioning
MU522_09685	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
MU522_09700	COG1022	Amp-dependent synthetase and ligase
MU522_09710	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
MU522_09715	COG0515	serine threonine protein kinase
MU522_09715	COG2815	serine threonine protein kinase
MU522_09725	COG0142	geranyltranstransferase activity
MU522_09735	COG2001	Belongs to the MraZ family
MU522_09740	COG0275	rRNA processing
MU522_09750	COG0768	penicillin binding
MU522_09755	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
MU522_09765	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
MU522_09770	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
MU522_09780	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
MU522_09785	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
MU522_09795	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
MU522_09800	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
MU522_09805	COG1799	cell septum assembly
MU522_09815	COG3599	regulation of cell shape
MU522_09820	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
MU522_09835	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
MU522_09840	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
MU522_09845	COG0167	dihydroorotate dehydrogenase activity
MU522_09855	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
MU522_09865	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
MU522_09870	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
MU522_09880	COG3573	Dehydrogenase
MU522_09900	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
MU522_09905	COG0698	ribose 5-phosphate isomerase
MU522_09970	COG1595	DNA-templated transcription, initiation
MU522_09975	COG0544	peptidyl-prolyl cis-trans isomerase activity
MU522_09980	COG0740	serine-type endopeptidase activity
MU522_09985	COG0740	serine-type endopeptidase activity
MU522_09995	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
MU522_10000	COG1120	ATPase activity
MU522_10005	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
MU522_10040	COG0535	radical SAM domain protein
MU522_10055	COG1028	Short-chain dehydrogenase reductase Sdr
MU522_10060	COG1028	Short-chain dehydrogenase reductase Sdr
MU522_10095	COG2409	Drug exporters of the RND superfamily
MU522_10110	COG0525	valine-tRNA ligase activity
MU522_10125	COG0477	Major facilitator Superfamily
MU522_10160	COG2197	response regulator
MU522_10170	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
MU522_10175	COG0285	dihydrofolate synthase activity
MU522_10185	COG0105	UTP biosynthetic process
MU522_10200	COG1530	ribonuclease E activity
MU522_10215	COG0261	This protein binds to 23S rRNA in the presence of protein L20
MU522_10220	COG0211	Belongs to the bacterial ribosomal protein bL27 family
MU522_10225	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
MU522_10230	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
MU522_10235	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
MU522_10245	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
MU522_10255	COG0799	negative regulation of ribosome biogenesis
MU522_10260	COG2514	catechol 2,3-dioxygenase activity
MU522_10275	COG0022	dehydrogenase e1 component
MU522_10280	COG0508	dehydrogenase complex catalyzes the overall conversion of
MU522_10285	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
MU522_10310	COG0569	domain protein
MU522_10315	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
MU522_10365	COG0395	ABC-type sugar transport system, permease component
MU522_10375	COG3842	ATPase activity
MU522_10385	COG1846	Transcriptional regulator
MU522_10410	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
MU522_10430	COG1695	Transcriptional regulator
MU522_10435	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
MU522_10450	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
MU522_10485	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MU522_10495	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MU522_10500	COG0601	transmembrane transport
MU522_10510	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
MU522_10515	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
MU522_10520	COG2873	o-acetylhomoserine
MU522_10540	COG0697	spore germination
MU522_10545	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
MU522_10590	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
MU522_10595	COG0723	plastoquinol--plastocyanin reductase activity
MU522_10600	COG2010	Cytochrome c
MU522_10605	COG1845	cytochrome c oxidase, subunit III
MU522_10610	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
MU522_10620	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
MU522_10625	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
MU522_10630	COG2376	Dihydroxyacetone kinase
MU522_10635	COG1461	Dihydroxyacetone kinase
MU522_10660	COG1794	racemase activity, acting on amino acids and derivatives
MU522_10695	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
MU522_10695	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
MU522_10705	COG1115	amino acid carrier protein
MU522_10730	COG3268	Saccharopine dehydrogenase
MU522_10740	COG1073	alpha beta
MU522_10740	COG2226	methyltransferase
MU522_10750	COG2815	serine threonine protein kinase
MU522_10750	COG0515	serine threonine protein kinase
MU522_10775	COG1846	Transcriptional regulator
MU522_10790	COG0626	cystathionine gamma-synthase activity
MU522_10795	COG3214	Protein conserved in bacteria
MU522_10800	COG1597	lipid kinase activity
MU522_10800	COG1803	Methylglyoxal synthase
MU522_10810	COG3415	Transposase
MU522_10810	COG2801	Transposase and inactivated derivatives
MU522_10815	COG0823	Involved in the tonB-independent uptake of proteins
MU522_10815	COG1506	peptidase
MU522_10815	COG4946	Tricorn protease homolog
MU522_10820	COG1028	Short-chain dehydrogenase reductase Sdr
MU522_10840	COG1216	Glycosyl transferase, family 2
MU522_10845	COG0815	Transfers the fatty acyl group on membrane lipoproteins
MU522_10855	COG0805	protein transport
MU522_10860	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
MU522_10895	COG0215	cysteine-tRNA ligase activity
MU522_10900	COG1968	undecaprenyl-diphosphatase activity
MU522_10905	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
MU522_10920	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
MU522_10930	COG1686	Belongs to the peptidase S11 family
MU522_10965	COG0254	rRNA binding
MU522_10970	COG1119	ATPase activity
MU522_10975	COG0297	glycogen (starch) synthase activity
MU522_10980	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
MU522_10985	COG0560	Phosphoserine phosphatase
MU522_11020	COG2860	membrane
MU522_11025	COG0488	(ABC) transporter
MU522_11035	COG1268	BioY protein
MU522_11050	COG2151	metal-sulfur cluster biosynthetic enzyme
MU522_11055	COG0396	ATPase activity
MU522_11065	COG0719	Fe-S assembly protein
MU522_11080	COG0248	Ppx GppA phosphatase
MU522_11085	COG0109	protoheme IX farnesyltransferase activity
MU522_11095	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
MU522_11100	COG0166	Belongs to the GPI family
MU522_11115	COG0363	glucosamine-6-phosphate deaminase activity
MU522_11125	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
MU522_11130	COG0149	triose-phosphate isomerase activity
MU522_11135	COG0126	phosphoglycerate kinase activity
MU522_11150	COG1481	regulation of sporulation
MU522_11155	COG1660	Displays ATPase and GTPase activities
MU522_11160	COG0322	excinuclease ABC activity
MU522_11170	COG4770	biotin carboxylase activity
MU522_11175	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
MU522_11180	COG4336	lyase activity
MU522_11185	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
MU522_11190	COG1914	H( )-stimulated, divalent metal cation uptake system
MU522_11200	COG0556	nucleotide-excision repair
MU522_11205	COG0237	dephospho-CoA kinase activity
MU522_11215	COG0745	RESPONSE REGULATOR receiver
MU522_11225	COG2205	protein histidine kinase activity
MU522_11240	COG0539	negative regulation of cytoplasmic translation
MU522_11260	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MU522_11295	COG0469	pyruvate kinase activity
MU522_11305	COG0070	glutamate synthase
MU522_11305	COG0067	glutamate synthase
MU522_11305	COG0069	glutamate synthase activity
MU522_11310	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
MU522_11315	COG0159	tryptophan synthase activity
MU522_11320	COG0133	tryptophan synthase activity
MU522_11325	COG0134	indole-3-glycerol-phosphate synthase activity
MU522_11350	COG0107	imidazoleglycerol-phosphate synthase activity
MU522_11355	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
MU522_11360	COG0140	phosphoribosyl-ATP diphosphatase activity
MU522_11365	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
MU522_11375	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
MU522_11380	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
MU522_11385	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
MU522_11395	COG1758	RNA polymerase activity
MU522_11400	COG0194	GDP metabolic process
MU522_11405	COG0284	orotidine-5'-phosphate decarboxylase activity
MU522_11410	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
MU522_11415	COG0505	Belongs to the CarA family
MU522_11425	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
MU522_11430	COG0540	Belongs to the ATCase OTCase family
MU522_11435	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
MU522_11440	COG2247	cell wall binding repeat
MU522_11440	COG0860	N-Acetylmuramoyl-L-alanine amidase
MU522_11450	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
MU522_11455	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
MU522_11460	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
MU522_11465	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
MU522_11470	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
MU522_11475	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
MU522_11480	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
MU522_11485	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
MU522_11490	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
MU522_11495	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
MU522_11505	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
MU522_11520	COG1196	nuclear chromosome segregation
MU522_11525	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
MU522_11530	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
MU522_11535	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
MU522_11545	COG2255	four-way junction helicase activity
MU522_11550	COG0632	four-way junction helicase activity
MU522_11560	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
MU522_11565	COG0217	transcriptional regulatory protein
MU522_11575	COG0697	spore germination
MU522_11580	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
MU522_11585	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
MU522_11595	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
MU522_11640	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
MU522_11670	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
MU522_11675	COG0183	Belongs to the thiolase family
MU522_11685	COG2890	protein-(glutamine-N5) methyltransferase activity
MU522_11700	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
MU522_11705	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
MU522_11720	COG0756	dUTP diphosphatase activity
MU522_11765	COG0187	DNA topoisomerase II activity
MU522_11775	COG1126	abc transporter atp-binding protein
MU522_11780	COG0765	amino acid transport
MU522_11785	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MU522_11790	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
MU522_11795	COG2223	nitrite transmembrane transporter activity
MU522_11805	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
MU522_11810	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MU522_11815	COG0508	dehydrogenase complex catalyzes the overall conversion of
MU522_11830	COG0174	glutamine synthetase
MU522_11840	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
MU522_11845	COG0174	glutamine synthetase
MU522_11850	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
MU522_11895	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
MU522_11910	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
MU522_11925	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
MU522_11930	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
MU522_11970	COG2154	pterin-4-alpha-carbinolamine dehydratase
MU522_11980	COG0438	transferase activity, transferring glycosyl groups
MU522_11990	COG0242	peptide deformylase activity
MU522_12005	COG0358	DNA primase activity
MU522_12020	COG0423	glycine-tRNA ligase activity
MU522_12030	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
MU522_12035	COG1381	Involved in DNA repair and RecF pathway recombination
MU522_12040	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
MU522_12045	COG2197	response regulator
MU522_12050	COG4585	Histidine kinase
MU522_12075	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
MU522_12085	COG0537	adenosine 5'-monophosphoramidase activity
MU522_12090	COG1385	rRNA (uridine-N3-)-methyltransferase activity
MU522_12095	COG0484	heat shock protein binding
MU522_12100	COG1420	regulation of RNA biosynthetic process
MU522_12120	COG0481	GTPase activity
MU522_12125	COG0268	Binds directly to 16S ribosomal RNA
MU522_12130	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
MU522_12150	COG1396	sequence-specific DNA binding
MU522_12160	COG1234	tRNA 3'-trailer cleavage
MU522_12175	COG0495	leucyl-tRNA aminoacylation
MU522_12185	COG0512	Glutamine amidotransferase of anthranilate synthase
MU522_12185	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
MU522_12200	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
MU522_12205	COG4988	ABC transporter
MU522_12210	COG1294	oxidase, subunit
MU522_12215	COG1271	oxidase subunit
MU522_12220	COG1309	transcriptional regulator
MU522_12225	COG2135	peptidase activity
MU522_12245	COG1946	Acyl-CoA thioesterase
MU522_12280	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
MU522_12295	COG0586	Pfam SNARE associated Golgi protein
MU522_12315	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
MU522_12340	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
MU522_12380	COG2217	Heavy metal translocating P-type atpase
MU522_12385	COG1937	Protein conserved in bacteria
MU522_12390	COG1748	Saccharopine dehydrogenase
MU522_12400	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
MU522_12425	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
MU522_12450	COG1064	alcohol dehydrogenase
MU522_12465	COG4172	Belongs to the ABC transporter superfamily
MU522_12470	COG4721	ABC-type cobalt transport system, permease component
MU522_12490	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MU522_12495	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MU522_12500	COG2261	transglycosylase associated protein
MU522_12505	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
MU522_12510	COG0154	amidase activity
MU522_12515	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
MU522_12540	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
MU522_12555	COG0482	sulfurtransferase activity
MU522_12560	COG0463	Glycosyl transferase, family 2
MU522_12580	COG0058	SHG alpha-glucan phosphorylase activity
MU522_12585	COG0366	Alpha amylase catalytic
MU522_12590	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
MU522_12595	COG3118	belongs to the thioredoxin family
MU522_12605	COG0628	permease
MU522_12630	COG0233	cytoplasmic translational termination
MU522_12635	COG0528	UMP kinase activity
MU522_12640	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
MU522_12645	COG0052	Belongs to the universal ribosomal protein uS2 family
MU522_12655	COG4974	Belongs to the 'phage' integrase family
MU522_12675	COG0792	nuclease activity
MU522_12690	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
MU522_12695	COG0681	Belongs to the peptidase S26 family
MU522_12700	COG0335	large ribosomal subunit rRNA binding
MU522_12710	COG0336	Belongs to the RNA methyltransferase TrmD family
MU522_12715	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
MU522_12720	COG1837	Belongs to the UPF0109 family
MU522_12725	COG0228	four-way junction DNA binding
MU522_12730	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
MU522_12735	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MU522_12770	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
MU522_12775	COG2813	Specifically methylates the guanine in position
MU522_12785	COG2827	Endonuclease containing a URI domain
MU522_12805	COG1012	belongs to the aldehyde dehydrogenase family
MU522_12815	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
MU522_12820	COG0571	ribonuclease III activity
MU522_12825	COG0333	Belongs to the bacterial ribosomal protein bL32 family
MU522_12845	COG2814	Major facilitator Superfamily
MU522_12865	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
MU522_12880	COG1253	flavin adenine dinucleotide binding
MU522_12900	COG0567	Dehydrogenase, E1 component
MU522_12900	COG0567	Dehydrogenase, E1 component
MU522_12900	COG0508	dehydrogenase complex catalyzes the overall conversion of
MU522_12900	COG0508	dehydrogenase complex catalyzes the overall conversion of
MU522_12905	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
MU522_12915	COG0489	protein tyrosine kinase activity
MU522_12920	COG0438	transferase activity, transferring glycosyl groups
MU522_12985	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
MU522_13000	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
MU522_13005	COG1162	GTPase activity
MU522_13010	COG0483	inositol monophosphate 1-phosphatase activity
MU522_13040	COG1012	belongs to the aldehyde dehydrogenase family
MU522_13055	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
MU522_13065	COG2884	Cell division ATP-binding protein ftsE
MU522_13075	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
MU522_13165	COG2267	carboxylic ester hydrolase activity
MU522_13175	COG1250	3-hydroxyacyl-CoA dehydrogenase
MU522_13180	COG1028	Short-chain dehydrogenase reductase Sdr
MU522_13195	COG1321	iron dependent repressor
MU522_13200	COG1108	ABC-type Mn2 Zn2 transport systems permease components
MU522_13205	COG1121	(ABC) transporter
MU522_13210	COG0803	Belongs to the bacterial solute-binding protein 9 family
MU522_13215	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
MU522_13220	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
MU522_13225	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
MU522_13235	COG1174	glycine betaine transport
MU522_13240	COG1174	glycine betaine transport