locus-tag	class	description
DSM26151_00010	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
DSM26151_00020	COG0592	DNA-directed DNA polymerase activity
DSM26151_00030	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
DSM26151_00040	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
DSM26151_00050	COG0187	DNA topoisomerase II activity
DSM26151_00060	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
DSM26151_00140	COG0539	negative regulation of cytoplasmic translation
DSM26151_00190	COG0705	Rhomboid family
DSM26151_00190	COG0457	Tetratricopeptide repeat
DSM26151_00210	COG3764	Sortase (surface protein transpeptidase)
DSM26151_00240	COG0515	serine threonine protein kinase
DSM26151_00250	COG0515	serine threonine protein kinase
DSM26151_00260	COG0768	penicillin binding
DSM26151_00290	COG1716	ATPase activity
DSM26151_00300	COG1716	ATPase activity
DSM26151_00380	COG0577	efflux transmembrane transporter activity
DSM26151_00390	COG1136	(ABC) transporter
DSM26151_00440	COG1175	transmembrane transport
DSM26151_00450	COG0395	ABC-type sugar transport system, permease component
DSM26151_00600	COG2801	Transposase and inactivated derivatives
DSM26151_00600	COG3415	Transposase
DSM26151_00620	COG1802	Transcriptional regulator
DSM26151_00650	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
DSM26151_00670	COG1028	Short-chain dehydrogenase reductase Sdr
DSM26151_00710	COG3285	dna ligase
DSM26151_00710	COG1793	dna ligase
DSM26151_00740	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DSM26151_00750	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DSM26151_00760	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DSM26151_00820	COG1090	epimerase
DSM26151_00830	COG3458	cephalosporin-C deacetylase activity
DSM26151_00850	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
DSM26151_00870	COG1349	DNA-binding transcription factor activity
DSM26151_00880	COG0191	fructose-bisphosphate aldolase activity
DSM26151_00910	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
DSM26151_00930	COG3591	Belongs to the peptidase S1B family
DSM26151_00930	COG1864	DNA RNA non-specific endonuclease
DSM26151_00950	COG5006	permease, DMT superfamily
DSM26151_01000	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DSM26151_01020	COG0386	Belongs to the glutathione peroxidase family
DSM26151_01030	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
DSM26151_01100	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
DSM26151_01110	COG0738	Major facilitator superfamily
DSM26151_01130	COG3119	arylsulfatase activity
DSM26151_01150	COG1653	transport
DSM26151_01160	COG1175	transmembrane transport
DSM26151_01190	COG0673	inositol 2-dehydrogenase activity
DSM26151_01200	COG1063	alcohol dehydrogenase
DSM26151_01210	COG0156	8-amino-7-oxononanoate synthase activity
DSM26151_01240	COG0534	Mate efflux family protein
DSM26151_01250	COG3304	Inner membrane component domain
DSM26151_01260	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
DSM26151_01270	COG0569	domain protein
DSM26151_01280	COG3590	peptidase
DSM26151_01320	COG2072	flavoprotein involved in K transport
DSM26151_01330	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
DSM26151_01370	COG0423	glycine-tRNA ligase activity
DSM26151_01400	COG0745	RESPONSE REGULATOR receiver
DSM26151_01410	COG2205	protein histidine kinase activity
DSM26151_01460	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
DSM26151_01480	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
DSM26151_01560	COG3253	May function as heme-dependent peroxidase
DSM26151_01570	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
DSM26151_01580	COG0181	hydroxymethylbilane synthase activity
DSM26151_01600	COG0534	Mate efflux family protein
DSM26151_01610	COG0113	porphobilinogen synthase activity
DSM26151_01620	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
DSM26151_01660	COG1131	(ABC) transporter
DSM26151_01740	COG1054	Belongs to the UPF0176 family
DSM26151_01750	COG1881	PFAM PEBP family protein
DSM26151_01760	COG1024	Enoyl-CoA hydratase
DSM26151_01820	COG0822	iron-sulfur transferase activity
DSM26151_01840	COG2079	MmgE PrpD family protein
DSM26151_01870	COG0824	Thioesterase
DSM26151_01870	COG1250	3-hydroxyacyl-CoA dehydrogenase
DSM26151_01940	COG1012	belongs to the aldehyde dehydrogenase family
DSM26151_01950	COG2801	Transposase and inactivated derivatives
DSM26151_01950	COG3415	Transposase
DSM26151_01970	COG2235	arginine
DSM26151_01980	COG4067	protein conserved in archaea
DSM26151_01980	COG0189	ligase activity
DSM26151_01990	COG0569	domain protein
DSM26151_01990	COG0189	ligase activity
DSM26151_02000	COG1725	Transcriptional regulator
DSM26151_02010	COG1522	sequence-specific DNA binding
DSM26151_02040	COG0531	amino acid
DSM26151_02070	COG1834	amidinotransferase
DSM26151_02080	COG3104	oligopeptide transport
DSM26151_02090	COG1216	Glycosyl transferase, family 2
DSM26151_02110	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
DSM26151_02240	COG2186	Transcriptional regulator
DSM26151_02260	COG0693	protein deglycase activity
DSM26151_02270	COG1414	Transcriptional regulator
DSM26151_02290	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DSM26151_02300	COG1070	Carbohydrate kinase
DSM26151_02310	COG3347	Dehydrogenase
DSM26151_02310	COG1028	Short-chain dehydrogenase reductase Sdr
DSM26151_02350	COG3250	beta-galactosidase activity
DSM26151_02390	COG2376	Dihydroxyacetone kinase
DSM26151_02400	COG0698	ribose 5-phosphate isomerase
DSM26151_02410	COG0149	triose-phosphate isomerase activity
DSM26151_02420	COG1082	Xylose isomerase domain protein TIM barrel
DSM26151_02430	COG2084	Dehydrogenase
DSM26151_02440	COG0477	Major facilitator Superfamily
DSM26151_02470	COG0588	phosphoglycerate mutase activity
DSM26151_02490	COG0095	Lipoate-protein ligase
DSM26151_02510	COG2189	Belongs to the N(4) N(6)-methyltransferase family
DSM26151_02540	COG0395	ABC-type sugar transport system, permease component
DSM26151_02580	COG1876	peptidase activity
DSM26151_02590	COG0477	Major facilitator Superfamily
DSM26151_02630	COG1819	glycosyl
DSM26151_02670	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DSM26151_02700	COG2182	Extracellular solute-binding protein
DSM26151_02710	COG1175	transmembrane transport
DSM26151_02720	COG0395	ABC-type sugar transport system, permease component
DSM26151_02730	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DSM26151_02740	COG1349	DNA-binding transcription factor activity
DSM26151_02790	COG0179	Fumarylacetoacetate (FAA) hydrolase
DSM26151_02810	COG0129	dihydroxy-acid dehydratase activity
DSM26151_02840	COG1597	lipid kinase activity
DSM26151_02850	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
DSM26151_02860	COG0561	phosphatase activity
DSM26151_02870	COG1316	TRANSCRIPTIONal
DSM26151_02890	COG1316	TRANSCRIPTIONal
DSM26151_02920	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
DSM26151_02950	COG3387	PFAM Glycoside hydrolase 15-related
DSM26151_02980	COG1846	Transcriptional regulator
DSM26151_03000	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
DSM26151_03050	COG0505	Belongs to the CarA family
DSM26151_03110	COG0569	domain protein
DSM26151_03120	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
DSM26151_03170	COG3263	regulation of cellular component size
DSM26151_03180	COG0017	Asparaginyl-tRNA synthetase
DSM26151_03190	COG0406	alpha-ribazole phosphatase activity
DSM26151_03210	COG0785	Cytochrome C biogenesis protein
DSM26151_03220	COG1333	cytochrome c biogenesis protein
DSM26151_03230	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
DSM26151_03280	COG4948	Mandelate Racemase Muconate Lactonizing
DSM26151_03360	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
DSM26151_03370	COG2326	polyphosphate kinase activity
DSM26151_03380	COG1169	isochorismate synthase
DSM26151_03400	COG2226	methyltransferase
DSM26151_03410	COG3559	Exporter of polyketide antibiotics
DSM26151_03420	COG1131	(ABC) transporter
DSM26151_03430	COG1309	transcriptional regulator
DSM26151_03440	COG0142	geranyltranstransferase activity
DSM26151_03550	COG1192	Involved in chromosome partitioning
DSM26151_03610	COG1666	GTP binding
DSM26151_03630	COG1609	Transcriptional regulator
DSM26151_03700	COG1609	Transcriptional regulator
DSM26151_03710	COG4948	Mandelate Racemase Muconate Lactonizing
DSM26151_03720	COG2186	Transcriptional regulator
DSM26151_03730	COG4948	Mandelate Racemase Muconate Lactonizing
DSM26151_03740	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
DSM26151_03740	COG0473	3-isopropylmalate dehydrogenase activity
DSM26151_03760	COG1175	transmembrane transport
DSM26151_03770	COG0395	ABC-type sugar transport system, permease component
DSM26151_03780	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
DSM26151_03810	COG0739	heme binding
DSM26151_03830	COG0366	Alpha amylase catalytic
DSM26151_03850	COG1175	transmembrane transport
DSM26151_03860	COG3833	ABC-type maltose transport systems, permease component
DSM26151_03920	COG0601	transmembrane transport
DSM26151_03930	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DSM26151_03940	COG0444	Belongs to the ABC transporter superfamily
DSM26151_03950	COG4608	Belongs to the ABC transporter superfamily
DSM26151_03970	COG0477	Major facilitator Superfamily
DSM26151_04000	COG0842	Transport permease protein
DSM26151_04000	COG1129	ABC transporter
DSM26151_04010	COG0842	Transport permease protein
DSM26151_04080	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
DSM26151_04150	COG4101	3-hydroxyanthranilate 3,4-dioxygenase activity
DSM26151_04180	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DSM26151_04190	COG4569	acetaldehyde dehydrogenase (acetylating) activity
DSM26151_04200	COG3971	2-oxopent-4-enoate hydratase activity
DSM26151_04230	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
DSM26151_04260	COG3842	ATPase activity
DSM26151_04300	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
DSM26151_04380	COG2197	response regulator
DSM26151_04390	COG2030	dehydratase
DSM26151_04410	COG0812	UDP-N-acetylmuramate dehydrogenase activity
DSM26151_04420	COG2197	response regulator
DSM26151_04430	COG4585	Histidine kinase
DSM26151_04480	COG0583	DNA-binding transcription factor activity
DSM26151_04500	COG0436	Aminotransferase
DSM26151_04540	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
DSM26151_04550	COG0081	regulation of translation
DSM26151_04560	COG2197	response regulator
DSM26151_04580	COG1254	Belongs to the acylphosphatase family
DSM26151_04600	COG2197	response regulator
DSM26151_04620	COG1012	belongs to the aldehyde dehydrogenase family
DSM26151_04700	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
DSM26151_04820	COG1012	belongs to the aldehyde dehydrogenase family
DSM26151_04840	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DSM26151_04870	COG1177	transmembrane transport
DSM26151_04900	COG3842	ATPase activity
DSM26151_04930	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
DSM26151_04960	COG0415	Belongs to the DNA photolyase family
DSM26151_04990	COG3321	synthase
DSM26151_04990	COG0604	alcohol dehydrogenase
DSM26151_05030	COG0673	inositol 2-dehydrogenase activity
DSM26151_05040	COG1129	ABC transporter
DSM26151_05050	COG1172	Belongs to the binding-protein-dependent transport system permease family
DSM26151_05100	COG0745	RESPONSE REGULATOR receiver
DSM26151_05110	COG2205	protein histidine kinase activity
DSM26151_05150	COG0477	Major facilitator Superfamily
DSM26151_05160	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
DSM26151_05170	COG0222	ribosome binding
DSM26151_05180	COG1653	transport
DSM26151_05190	COG1175	transmembrane transport
DSM26151_05200	COG0395	ABC-type sugar transport system, permease component
DSM26151_05210	COG1132	(ABC) transporter
DSM26151_05260	COG0531	amino acid
DSM26151_05350	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DSM26151_05360	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DSM26151_05380	COG3620	sequence-specific DNA binding
DSM26151_05410	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
DSM26151_05430	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DSM26151_05480	COG1053	succinate dehydrogenase
DSM26151_05490	COG0583	DNA-binding transcription factor activity
DSM26151_05530	COG3973	AAA domain
DSM26151_05600	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
DSM26151_05610	COG1140	nitrate reductase beta subunit
DSM26151_05640	COG0385	Bile acid
DSM26151_05690	COG0477	Major facilitator Superfamily
DSM26151_05720	COG0659	secondary active sulfate transmembrane transporter activity
DSM26151_05810	COG2409	Drug exporters of the RND superfamily
DSM26151_05850	COG0019	diaminopimelate decarboxylase activity
DSM26151_05940	COG0640	Transcriptional regulator
DSM26151_05970	COG2186	Transcriptional regulator
DSM26151_05980	COG4948	Mandelate Racemase Muconate Lactonizing
DSM26151_06000	COG1804	L-carnitine dehydratase bile acid-inducible protein F
DSM26151_06020	COG1024	Enoyl-CoA hydratase
DSM26151_06060	COG0800	Aldolase
DSM26151_06070	COG1028	Short-chain dehydrogenase reductase Sdr
DSM26151_06080	COG1063	alcohol dehydrogenase
DSM26151_06100	COG2186	Transcriptional regulator
DSM26151_06120	COG0179	Fumarylacetoacetate (FAA) hydrolase
DSM26151_06130	COG1028	Short-chain dehydrogenase reductase Sdr
DSM26151_06290	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
DSM26151_06300	COG1695	Transcriptional regulator
DSM26151_06400	COG0488	(ABC) transporter
DSM26151_06440	COG0542	response to heat
DSM26151_06510	COG0154	amidase activity
DSM26151_06530	COG1819	glycosyl
DSM26151_06540	COG1309	transcriptional regulator
DSM26151_06550	COG2226	methyltransferase
DSM26151_06580	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
DSM26151_06630	COG1940	carbohydrate kinase activity
DSM26151_06690	COG1063	alcohol dehydrogenase
DSM26151_06700	COG0454	-acetyltransferase
DSM26151_06710	COG1595	DNA-templated transcription, initiation
DSM26151_06730	COG0492	ferredoxin-NADP+ reductase activity
DSM26151_06800	COG1793	dna ligase
DSM26151_06820	COG0406	alpha-ribazole phosphatase activity
DSM26151_06870	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
DSM26151_07000	COG1396	sequence-specific DNA binding
DSM26151_07060	COG1396	sequence-specific DNA binding
DSM26151_07070	COG0740	serine-type endopeptidase activity
DSM26151_07080	COG0740	serine-type endopeptidase activity
DSM26151_07120	COG1253	flavin adenine dinucleotide binding
DSM26151_07150	COG4552	Acetyltransferase involved in intracellular survival and related
DSM26151_07170	COG1929	Belongs to the glycerate kinase type-1 family
DSM26151_07200	COG1070	Carbohydrate kinase
DSM26151_07210	COG2115	Belongs to the xylose isomerase family
DSM26151_07230	COG1846	Transcriptional regulator
DSM26151_07240	COG1940	carbohydrate kinase activity
DSM26151_07250	COG2814	Major facilitator Superfamily
DSM26151_07280	COG1529	Aldehyde oxidase and xanthine dehydrogenase
DSM26151_07300	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
DSM26151_07320	COG3257	ureidoglycine aminohydrolase activity
DSM26151_07330	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
DSM26151_07350	COG2351	hydroxyisourate hydrolase activity
DSM26151_07400	COG4948	Mandelate Racemase Muconate Lactonizing
DSM26151_07430	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DSM26151_07450	COG0433	COG0433 Predicted ATPase
DSM26151_07520	COG2072	flavoprotein involved in K transport
DSM26151_07540	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
DSM26151_07590	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
DSM26151_07630	COG0579	oxidoreductase
DSM26151_07640	COG0488	(ABC) transporter
DSM26151_07740	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
DSM26151_07750	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
DSM26151_07760	COG1088	dTDP-glucose 4,6-dehydratase activity
DSM26151_07800	COG1215	transferase activity, transferring glycosyl groups
DSM26151_07850	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DSM26151_07880	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DSM26151_07950	COG2079	MmgE PrpD family protein
DSM26151_07960	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
DSM26151_07980	COG1754	DNA topoisomerase type I activity
DSM26151_07980	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
DSM26151_07990	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
DSM26151_08000	COG0470	DNA polymerase III
DSM26151_08030	COG2755	lipolytic protein G-D-S-L family
DSM26151_08060	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DSM26151_08080	COG1335	isochorismatase
DSM26151_08160	COG0583	DNA-binding transcription factor activity
DSM26151_08230	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
DSM26151_08250	COG3971	2-oxopent-4-enoate hydratase activity
DSM26151_08290	COG0183	Belongs to the thiolase family
DSM26151_08340	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
DSM26151_08380	COG1132	(ABC) transporter
DSM26151_08400	COG2313	pseudouridylate synthase activity
DSM26151_08410	COG0318	PFAM AMP-dependent synthetase and ligase
DSM26151_08420	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
DSM26151_08430	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DSM26151_08430	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DSM26151_08470	COG2390	Transcriptional regulator
DSM26151_08480	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
DSM26151_08490	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
DSM26151_08500	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
DSM26151_08550	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
DSM26151_08580	COG2009	succinate dehydrogenase
DSM26151_08590	COG0662	Cupin 2, conserved barrel domain protein
DSM26151_08590	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
DSM26151_08600	COG1744	ABC transporter substrate-binding protein PnrA-like
DSM26151_08620	COG3845	ABC transporter
DSM26151_08630	COG4603	Belongs to the binding-protein-dependent transport system permease family
DSM26151_08640	COG1079	Belongs to the binding-protein-dependent transport system permease family
DSM26151_08670	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
DSM26151_08730	COG4770	biotin carboxylase activity
DSM26151_08740	COG0424	maF-like protein
DSM26151_08750	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
DSM26151_08800	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
DSM26151_08860	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
DSM26151_08870	COG1316	TRANSCRIPTIONal
DSM26151_08890	COG1216	Glycosyl transferase, family 2
DSM26151_08940	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
DSM26151_08960	COG1216	Glycosyl transferase, family 2
DSM26151_09000	COG0673	inositol 2-dehydrogenase activity
DSM26151_09010	COG1132	(ABC) transporter
DSM26151_09060	COG2089	acid synthase
DSM26151_09070	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
DSM26151_09080	COG1086	Polysaccharide biosynthesis protein
DSM26151_09100	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
DSM26151_09110	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
DSM26151_09130	COG1216	Glycosyl transferase, family 2
DSM26151_09150	COG2226	methyltransferase
DSM26151_09220	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
DSM26151_09230	COG1960	acyl-CoA dehydrogenase activity
DSM26151_09240	COG1482	cell wall glycoprotein biosynthetic process
DSM26151_09260	COG1216	Glycosyl transferase, family 2
DSM26151_09260	COG1442	glycosyl transferase family 8
DSM26151_09270	COG4977	sequence-specific DNA binding
DSM26151_09350	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DSM26151_09360	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
DSM26151_09390	COG0071	Belongs to the small heat shock protein (HSP20) family
DSM26151_09420	COG0714	Associated with various cellular activities
DSM26151_09460	COG0745	RESPONSE REGULATOR receiver
DSM26151_09470	COG5002	protein histidine kinase activity
DSM26151_09480	COG5401	PFAM Sporulation and spore germination
DSM26151_09490	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
DSM26151_09500	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
DSM26151_09510	COG0653	protein targeting
DSM26151_09630	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
DSM26151_09640	COG1595	DNA-templated transcription, initiation
DSM26151_09660	COG2409	Drug exporters of the RND superfamily
DSM26151_09670	COG0508	dehydrogenase complex catalyzes the overall conversion of
DSM26151_09670	COG0567	Dehydrogenase, E1 component
DSM26151_09720	COG1902	pentaerythritol trinitrate reductase activity
DSM26151_09760	COG2197	response regulator
DSM26151_09790	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
DSM26151_09830	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DSM26151_09850	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
DSM26151_09860	COG3265	gluconokinase activity
DSM26151_09880	COG0154	amidase activity
DSM26151_09900	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DSM26151_09910	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DSM26151_09920	COG1120	ATPase activity
DSM26151_09950	COG0010	Belongs to the arginase family
DSM26151_09960	COG0484	heat shock protein binding
DSM26151_09970	COG1842	Phage shock protein A
DSM26151_10010	COG0018	arginyl-trna synthetase
DSM26151_10030	COG0019	diaminopimelate decarboxylase activity
DSM26151_10040	COG0460	homoserine dehydrogenase
DSM26151_10060	COG0083	homoserine kinase activity
DSM26151_10080	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
DSM26151_10100	COG1045	serine acetyltransferase
DSM26151_10120	COG2890	protein-(glutamine-N5) methyltransferase activity
DSM26151_10170	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DSM26151_10190	COG0356	it plays a direct role in the translocation of protons across the membrane
DSM26151_10200	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
DSM26151_10210	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
DSM26151_10220	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
DSM26151_10230	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
DSM26151_10240	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
DSM26151_10250	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
DSM26151_10260	COG0355	proton-transporting ATP synthase activity, rotational mechanism
DSM26151_10280	COG2801	Transposase and inactivated derivatives
DSM26151_10280	COG3415	Transposase
DSM26151_10300	COG2818	Glycosylase
DSM26151_10310	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
DSM26151_10330	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
DSM26151_10360	COG0631	protein serine/threonine phosphatase activity
DSM26151_10390	COG0714	Associated with various cellular activities
DSM26151_10450	COG3842	ATPase activity
DSM26151_10460	COG1176	ABC-type spermidine putrescine transport system, permease component I
DSM26151_10520	COG0204	Acyl-transferase
DSM26151_10520	COG0318	PFAM AMP-dependent synthetase and ligase
DSM26151_10540	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
DSM26151_10550	COG0750	zinc metalloprotease
DSM26151_10560	COG0183	Belongs to the thiolase family
DSM26151_10580	COG1137	ATPase activity
DSM26151_10620	COG0318	PFAM AMP-dependent synthetase and ligase
DSM26151_10630	COG1309	transcriptional regulator
DSM26151_10640	COG1028	Short-chain dehydrogenase reductase Sdr
DSM26151_10650	COG0596	Alpha beta hydrolase
DSM26151_10690	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
DSM26151_10710	COG0442	prolyl-tRNA aminoacylation
DSM26151_10740	COG1115	amino acid carrier protein
DSM26151_10760	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
DSM26151_10770	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
DSM26151_10790	COG1194	a g-specific adenine glycosylase
DSM26151_10820	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
DSM26151_10830	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
DSM26151_10860	COG0196	riboflavin kinase activity
DSM26151_10870	COG0477	Major facilitator Superfamily
DSM26151_10890	COG2390	Transcriptional regulator
DSM26151_10900	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
DSM26151_10910	COG1012	belongs to the aldehyde dehydrogenase family
DSM26151_10920	COG1012	belongs to the aldehyde dehydrogenase family
DSM26151_10940	COG0702	epimerase
DSM26151_10970	COG1937	Protein conserved in bacteria
DSM26151_11010	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
DSM26151_11030	COG1051	belongs to the nudix hydrolase family
DSM26151_11060	COG2252	PERMEase
DSM26151_11070	COG2233	PERMEase
DSM26151_11110	COG0179	Fumarylacetoacetate (FAA) hydrolase
DSM26151_11130	COG0277	FAD linked oxidase domain protein
DSM26151_11160	COG0545	Peptidyl-prolyl cis-trans isomerase
DSM26151_11290	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
DSM26151_11300	COG3189	MarR family transcriptional regulator
DSM26151_11310	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
DSM26151_11380	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DSM26151_11480	COG1131	(ABC) transporter
DSM26151_11490	COG1185	polyribonucleotide nucleotidyltransferase activity
DSM26151_11550	COG0022	dehydrogenase e1 component
DSM26151_11560	COG0508	dehydrogenase complex catalyzes the overall conversion of
DSM26151_11570	COG2154	pterin-4-alpha-carbinolamine dehydratase
DSM26151_11600	COG1309	transcriptional regulator
DSM26151_11610	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
DSM26151_11630	COG1960	acyl-CoA dehydrogenase activity
DSM26151_11660	COG2086	electron transfer activity
DSM26151_11670	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
DSM26151_11700	COG0667	Aldo Keto reductase
DSM26151_11710	COG0612	Peptidase, M16
DSM26151_11740	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
DSM26151_11760	COG1090	epimerase
DSM26151_11770	COG1764	response to oxidative stress
DSM26151_11780	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
DSM26151_11810	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DSM26151_11820	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
DSM26151_11830	COG1674	ftsk spoiiie
DSM26151_11850	COG1058	Belongs to the CinA family
DSM26151_11850	COG1546	Belongs to the CinA family
DSM26151_11860	COG1396	sequence-specific DNA binding
DSM26151_11890	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
DSM26151_11900	COG2137	regulation of response to DNA damage stimulus
DSM26151_11910	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DSM26151_11920	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
DSM26151_11930	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
DSM26151_11940	COG2813	Specifically methylates the guanine in position
DSM26151_11950	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
DSM26151_11960	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
DSM26151_11980	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
DSM26151_12000	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DSM26151_12010	COG0131	Imidazoleglycerol-phosphate dehydratase
DSM26151_12020	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
DSM26151_12030	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
DSM26151_12050	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
DSM26151_12050	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
DSM26151_12060	COG1201	RNA secondary structure unwinding
DSM26151_12070	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
DSM26151_12090	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
DSM26151_12100	COG0291	Belongs to the bacterial ribosomal protein bL35 family
DSM26151_12110	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
DSM26151_12120	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DSM26151_12130	COG1126	abc transporter atp-binding protein
DSM26151_12140	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DSM26151_12150	COG0765	amino acid transport
DSM26151_12160	COG0765	amino acid transport
DSM26151_12170	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
DSM26151_12180	COG0072	phenylalanine-tRNA ligase activity
DSM26151_12180	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DSM26151_12200	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
DSM26151_12210	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
DSM26151_12220	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
DSM26151_12240	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
DSM26151_12250	COG0165	Argininosuccinate lyase
DSM26151_12260	COG2094	Belongs to the DNA glycosylase MPG family
DSM26151_12290	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
DSM26151_12300	COG1804	L-carnitine dehydratase bile acid-inducible protein F
DSM26151_12360	COG0647	UMP catabolic process
DSM26151_12380	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
DSM26151_12390	COG0497	DNA recombination
DSM26151_12400	COG0504	CTP synthase activity
DSM26151_12410	COG0494	nUDIX hydrolase
DSM26151_12440	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
DSM26151_12450	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
DSM26151_12480	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
DSM26151_12490	COG1160	GTP binding
DSM26151_12550	COG0667	Aldo Keto reductase
DSM26151_12560	COG3119	arylsulfatase activity
DSM26151_12580	COG1175	transmembrane transport
DSM26151_12590	COG0395	ABC-type sugar transport system, permease component
DSM26151_12600	COG3119	arylsulfatase activity
DSM26151_12620	COG1609	Transcriptional regulator
DSM26151_12680	COG2357	RelA SpoT domain protein
DSM26151_12690	COG3012	SEC-C Motif Domain Protein
DSM26151_12760	COG1233	COG1233 Phytoene dehydrogenase and related
DSM26151_12780	COG0142	geranyltranstransferase activity
DSM26151_12820	COG1716	ATPase activity
DSM26151_12850	COG1192	Involved in chromosome partitioning
DSM26151_12900	COG1940	carbohydrate kinase activity
DSM26151_12920	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
DSM26151_12930	COG0515	serine threonine protein kinase
DSM26151_12930	COG2815	serine threonine protein kinase
DSM26151_12960	COG0142	geranyltranstransferase activity
DSM26151_12980	COG2001	Belongs to the MraZ family
DSM26151_12990	COG0275	rRNA processing
DSM26151_13010	COG0768	penicillin binding
DSM26151_13020	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
DSM26151_13040	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DSM26151_13050	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
DSM26151_13070	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
DSM26151_13080	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
DSM26151_13100	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
DSM26151_13120	COG1799	cell septum assembly
DSM26151_13150	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
DSM26151_13170	COG0587	DNA-directed DNA polymerase activity
DSM26151_13180	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
DSM26151_13190	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
DSM26151_13200	COG0167	dihydroorotate dehydrogenase activity
DSM26151_13220	COG1253	flavin adenine dinucleotide binding
DSM26151_13260	COG1174	glycine betaine transport
DSM26151_13290	COG0586	Pfam SNARE associated Golgi protein
DSM26151_13320	COG1271	oxidase subunit
DSM26151_13330	COG1294	oxidase, subunit
DSM26151_13340	COG4988	ABC transporter
DSM26151_13350	COG1132	(ABC) transporter
DSM26151_13370	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
DSM26151_13370	COG0512	Glutamine amidotransferase of anthranilate synthase
DSM26151_13380	COG0495	leucyl-tRNA aminoacylation
DSM26151_13420	COG0268	Binds directly to 16S ribosomal RNA
DSM26151_13440	COG2197	response regulator
DSM26151_13450	COG4585	Histidine kinase
DSM26151_13460	COG0481	GTPase activity
DSM26151_13510	COG1420	regulation of RNA biosynthetic process
DSM26151_13520	COG0484	heat shock protein binding
DSM26151_13540	COG0537	adenosine 5'-monophosphoramidase activity
DSM26151_13560	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
DSM26151_13580	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
DSM26151_13590	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DSM26151_13600	COG2860	membrane
DSM26151_13610	COG1090	epimerase
DSM26151_13620	COG1381	Involved in DNA repair and RecF pathway recombination
DSM26151_13630	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
DSM26151_13640	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
DSM26151_13660	COG0442	prolyl-tRNA aminoacylation
DSM26151_13680	COG0232	Belongs to the dGTPase family. Type 2 subfamily
DSM26151_13690	COG0358	DNA primase activity
DSM26151_13710	COG2801	Transposase and inactivated derivatives
DSM26151_13710	COG3415	Transposase
DSM26151_13720	COG0601	transmembrane transport
DSM26151_13740	COG4172	Belongs to the ABC transporter superfamily
DSM26151_13800	COG0242	peptide deformylase activity
DSM26151_13820	COG0297	glycogen (starch) synthase activity
DSM26151_13890	COG2801	Transposase and inactivated derivatives
DSM26151_13910	COG0583	DNA-binding transcription factor activity
DSM26151_13920	COG1609	Transcriptional regulator
DSM26151_13940	COG1175	transmembrane transport
DSM26151_13950	COG0395	ABC-type sugar transport system, permease component
DSM26151_13960	COG3250	beta-galactosidase activity
DSM26151_13970	COG1472	Belongs to the glycosyl hydrolase 3 family
DSM26151_13980	COG1960	acyl-CoA dehydrogenase activity
DSM26151_14040	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DSM26151_14050	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DSM26151_14080	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
DSM26151_14110	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
DSM26151_14160	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
DSM26151_14170	COG0174	glutamine synthetase
DSM26151_14180	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
DSM26151_14190	COG0174	glutamine synthetase
DSM26151_14220	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
DSM26151_14230	COG0321	lipoyl(octanoyl) transferase activity
DSM26151_14250	COG0508	dehydrogenase complex catalyzes the overall conversion of
DSM26151_14260	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DSM26151_14270	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
DSM26151_14290	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
DSM26151_14300	COG0189	ligase activity
DSM26151_14300	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
DSM26151_14330	COG0187	DNA topoisomerase II activity
DSM26151_14340	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
DSM26151_14370	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DSM26151_14390	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
DSM26151_14400	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
DSM26151_14430	COG2226	methyltransferase
DSM26151_14440	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
DSM26151_14450	COG0723	plastoquinol--plastocyanin reductase activity
DSM26151_14460	COG2010	Cytochrome c
DSM26151_14470	COG1845	cytochrome c oxidase, subunit III
DSM26151_14480	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
DSM26151_14490	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
DSM26151_14500	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
DSM26151_14510	COG2376	Dihydroxyacetone kinase
DSM26151_14520	COG1461	Dihydroxyacetone kinase
DSM26151_14530	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
DSM26151_14530	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
DSM26151_14530	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DSM26151_14620	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
DSM26151_14660	COG1028	Short-chain dehydrogenase reductase Sdr
DSM26151_14690	COG0584	glycerophosphoryl diester phosphodiesterase
DSM26151_14730	COG0805	protein transport
DSM26151_14740	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
DSM26151_14790	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DSM26151_14810	COG1968	undecaprenyl-diphosphatase activity
DSM26151_14820	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DSM26151_14860	COG0587	DNA-directed DNA polymerase activity
DSM26151_14910	COG0626	cystathionine gamma-synthase activity
DSM26151_14960	COG1686	Belongs to the peptidase S11 family
DSM26151_14980	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
DSM26151_14990	COG0588	phosphoglycerate mutase activity
DSM26151_15040	COG0254	rRNA binding
DSM26151_15050	COG1119	ATPase activity
DSM26151_15060	COG0297	glycogen (starch) synthase activity
DSM26151_15070	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
DSM26151_15080	COG0560	Phosphoserine phosphatase
DSM26151_15160	COG0488	(ABC) transporter
DSM26151_15190	COG1472	Belongs to the glycosyl hydrolase 3 family
DSM26151_15250	COG0508	dehydrogenase complex catalyzes the overall conversion of
DSM26151_15280	COG3328	transposase activity
DSM26151_15370	COG3328	transposase activity
DSM26151_15420	COG3328	transposase activity
DSM26151_15440	COG0799	negative regulation of ribosome biogenesis
DSM26151_15460	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
DSM26151_15480	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
DSM26151_15490	COG4585	Histidine kinase
DSM26151_15500	COG2197	response regulator
DSM26151_15510	COG4152	abc transporter atp-binding protein
DSM26151_15530	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
DSM26151_15540	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
DSM26151_15550	COG0211	Belongs to the bacterial ribosomal protein bL27 family
DSM26151_15560	COG0261	This protein binds to 23S rRNA in the presence of protein L20
DSM26151_15580	COG1530	ribonuclease E activity
DSM26151_15620	COG0285	dihydrofolate synthase activity
DSM26151_15630	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
DSM26151_15650	COG0477	Major facilitator Superfamily
DSM26151_15660	COG0525	valine-tRNA ligase activity
DSM26151_15690	COG2151	metal-sulfur cluster biosynthetic enzyme
DSM26151_15700	COG0396	ATPase activity
DSM26151_15740	COG1612	heme a metabolic process
DSM26151_15750	COG0109	protoheme IX farnesyltransferase activity
DSM26151_15760	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
DSM26151_15770	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
DSM26151_15800	COG0363	glucosamine-6-phosphate deaminase activity
DSM26151_15820	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
DSM26151_15830	COG0149	triose-phosphate isomerase activity
DSM26151_15840	COG0126	phosphoglycerate kinase activity
DSM26151_15850	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
DSM26151_15860	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
DSM26151_15870	COG1481	regulation of sporulation
DSM26151_15880	COG1660	Displays ATPase and GTPase activities
DSM26151_15890	COG0322	excinuclease ABC activity
DSM26151_15910	COG0556	nucleotide-excision repair
DSM26151_15920	COG0237	dephospho-CoA kinase activity
DSM26151_15930	COG0539	negative regulation of cytoplasmic translation
DSM26151_16000	COG0067	glutamate synthase
DSM26151_16000	COG0069	glutamate synthase activity
DSM26151_16000	COG0070	glutamate synthase
DSM26151_16010	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
DSM26151_16020	COG0159	tryptophan synthase activity
DSM26151_16030	COG0133	tryptophan synthase activity
DSM26151_16040	COG0134	indole-3-glycerol-phosphate synthase activity
DSM26151_16080	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
DSM26151_16090	COG0107	imidazoleglycerol-phosphate synthase activity
DSM26151_16100	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
DSM26151_16110	COG0140	phosphoribosyl-ATP diphosphatase activity
DSM26151_16120	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
DSM26151_16140	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
DSM26151_16160	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
DSM26151_16180	COG1758	RNA polymerase activity
DSM26151_16190	COG0194	GDP metabolic process
DSM26151_16200	COG0284	orotidine-5'-phosphate decarboxylase activity
DSM26151_16210	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
DSM26151_16220	COG0505	Belongs to the CarA family
DSM26151_16240	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
DSM26151_16250	COG0540	Belongs to the ATCase OTCase family
DSM26151_16260	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
DSM26151_16270	COG1028	Short-chain dehydrogenase reductase Sdr
DSM26151_16290	COG1819	glycosyl
DSM26151_16300	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DSM26151_16310	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
DSM26151_16320	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
DSM26151_16330	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
DSM26151_16340	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
DSM26151_16350	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
DSM26151_16360	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
DSM26151_16380	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
DSM26151_16390	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
DSM26151_16410	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
DSM26151_16460	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
DSM26151_16470	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DSM26151_16480	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DSM26151_16500	COG2255	four-way junction helicase activity
DSM26151_16510	COG0632	four-way junction helicase activity
DSM26151_16520	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
DSM26151_16530	COG0217	transcriptional regulatory protein
DSM26151_16550	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
DSM26151_16560	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
DSM26151_16580	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
DSM26151_16600	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
DSM26151_16720	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
DSM26151_16730	COG0183	Belongs to the thiolase family
DSM26151_16740	COG1250	3-hydroxyacyl-CoA dehydrogenase
DSM26151_16740	COG1024	Enoyl-CoA hydratase
DSM26151_16750	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
DSM26151_16760	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
DSM26151_16790	COG0756	dUTP diphosphatase activity
DSM26151_16830	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
DSM26151_16840	COG0740	serine-type endopeptidase activity
DSM26151_16850	COG0740	serine-type endopeptidase activity
DSM26151_16870	COG0544	peptidyl-prolyl cis-trans isomerase activity
DSM26151_16920	COG0783	Belongs to the Dps family
DSM26151_16940	COG2197	response regulator
DSM26151_16960	COG1574	metal-dependent hydrolase with the TIM-barrel fold
DSM26151_17050	COG1946	Acyl-CoA thioesterase
DSM26151_17110	COG0629	single-stranded DNA binding
DSM26151_17120	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DSM26151_17130	COG0667	Aldo Keto reductase
DSM26151_17150	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
DSM26151_17170	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
DSM26151_17240	COG4172	Belongs to the ABC transporter superfamily
DSM26151_17250	COG4721	ABC-type cobalt transport system, permease component
DSM26151_17270	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
DSM26151_17290	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DSM26151_17300	COG0154	amidase activity
DSM26151_17310	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DSM26151_17320	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
DSM26151_17370	COG0482	sulfurtransferase activity
DSM26151_17390	COG1523	belongs to the glycosyl hydrolase 13 family
DSM26151_17420	COG0366	Alpha amylase catalytic
DSM26151_17430	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
DSM26151_17530	COG0233	cytoplasmic translational termination
DSM26151_17540	COG0528	UMP kinase activity
DSM26151_17550	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
DSM26151_17560	COG0052	Belongs to the universal ribosomal protein uS2 family
DSM26151_17580	COG4974	Belongs to the 'phage' integrase family
DSM26151_17620	COG0792	nuclease activity
DSM26151_17640	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
DSM26151_17650	COG0681	Belongs to the peptidase S26 family
DSM26151_17660	COG0335	large ribosomal subunit rRNA binding
DSM26151_17680	COG0024	Methionine aminopeptidase
DSM26151_17700	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DSM26151_17700	COG2146	nitrite reductase [NAD(P)H] activity
DSM26151_17710	COG1648	precorrin-2 dehydrogenase activity
DSM26151_17710	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
DSM26151_17730	COG2223	nitrite transmembrane transporter activity
DSM26151_17740	COG0243	molybdopterin cofactor binding
DSM26151_17770	COG0336	Belongs to the RNA methyltransferase TrmD family
DSM26151_17780	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
DSM26151_17790	COG1837	Belongs to the UPF0109 family
DSM26151_17800	COG0228	four-way junction DNA binding
DSM26151_17810	COG0006	proline dipeptidase activity
DSM26151_17860	COG3938	Belongs to the proline racemase family
DSM26151_17900	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DSM26151_17910	COG1802	Transcriptional regulator
DSM26151_17920	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
DSM26151_17930	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
DSM26151_17980	COG1196	nuclear chromosome segregation
DSM26151_18010	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
DSM26151_18020	COG0571	ribonuclease III activity
DSM26151_18030	COG0333	Belongs to the bacterial ribosomal protein bL32 family
DSM26151_18070	COG0714	Associated with various cellular activities
DSM26151_18080	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
DSM26151_18090	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
DSM26151_18110	COG0742	ribosomal rna small subunit methyltransferase
DSM26151_18140	COG1181	Belongs to the D-alanine--D-alanine ligase family
DSM26151_18150	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
DSM26151_18170	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
DSM26151_18180	COG0066	3-isopropylmalate dehydratase activity
DSM26151_18190	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
DSM26151_18230	COG0714	Associated with various cellular activities
DSM26151_18260	COG0515	serine threonine protein kinase
DSM26151_18260	COG2815	serine threonine protein kinase
DSM26151_18280	COG0631	protein serine/threonine phosphatase activity
DSM26151_18330	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
DSM26151_18360	COG1172	Belongs to the binding-protein-dependent transport system permease family
DSM26151_18370	COG1172	Belongs to the binding-protein-dependent transport system permease family
DSM26151_18380	COG1129	ABC transporter
DSM26151_18400	COG0657	acetylesterase activity
DSM26151_18420	COG3328	transposase activity
DSM26151_18500	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DSM26151_18510	COG0583	DNA-binding transcription factor activity
DSM26151_18560	COG0179	Fumarylacetoacetate (FAA) hydrolase
DSM26151_18570	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
DSM26151_18580	COG0473	3-isopropylmalate dehydrogenase activity
DSM26151_18600	COG0477	Major facilitator Superfamily
DSM26151_18690	COG3142	Participates in the control of copper homeostasis
DSM26151_18700	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
DSM26151_18710	COG0440	acetolactate synthase activity
DSM26151_18720	COG0028	Belongs to the TPP enzyme family
DSM26151_18730	COG0129	dihydroxy-acid dehydratase activity
DSM26151_18740	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
DSM26151_18750	COG1082	Xylose isomerase domain protein TIM barrel
DSM26151_18760	COG1511	domain protein
DSM26151_18770	COG2409	Drug exporters of the RND superfamily
DSM26151_18780	COG1309	transcriptional regulator
DSM26151_18810	COG1268	BioY protein
DSM26151_18830	COG0183	Belongs to the thiolase family
DSM26151_18840	COG1122	ATPase activity
DSM26151_18880	COG0483	inositol monophosphate 1-phosphatase activity
DSM26151_18950	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
DSM26151_18960	COG2177	Part of the ABC transporter FtsEX involved in
DSM26151_18970	COG2884	Cell division ATP-binding protein ftsE
DSM26151_18980	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
DSM26151_19130	COG0586	Pfam SNARE associated Golgi protein
DSM26151_19170	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
DSM26151_19180	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
DSM26151_19190	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
DSM26151_19320	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DSM26151_19340	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DSM26151_19360	COG1733	regulation of RNA biosynthetic process
DSM26151_19400	COG1615	UPF0182 protein
DSM26151_19410	COG3480	Lon protease (S16) C-terminal proteolytic domain
DSM26151_19470	COG0210	DNA helicase
DSM26151_19520	COG0513	Belongs to the DEAD box helicase family
DSM26151_19530	COG0613	PHP domain protein
DSM26151_19550	COG0006	proline dipeptidase activity
DSM26151_19570	COG2239	Acts as a magnesium transporter
DSM26151_19620	COG2211	Major facilitator Superfamily
DSM26151_19630	COG1012	belongs to the aldehyde dehydrogenase family
DSM26151_19640	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
DSM26151_19680	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DSM26151_19690	COG2171	N-acyltransferase activity
DSM26151_19790	COG1024	Enoyl-CoA hydratase
DSM26151_19800	COG1196	nuclear chromosome segregation
DSM26151_19800	COG0741	lytic transglycosylase activity
DSM26151_19800	COG0739	heme binding
DSM26151_19810	COG1217	gtp-binding protein TYPA
DSM26151_19830	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DSM26151_19840	COG0601	transmembrane transport
DSM26151_19850	COG4166	transmembrane transport
DSM26151_19890	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
DSM26151_19890	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
DSM26151_19900	COG0509	glycine decarboxylation via glycine cleavage system
DSM26151_19910	COG0404	The glycine cleavage system catalyzes the degradation of glycine
DSM26151_19920	COG2132	Multicopper oxidase
DSM26151_19950	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
DSM26151_19960	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
DSM26151_19980	COG1104	cysteine desulfurase activity
DSM26151_19990	COG2814	Major facilitator Superfamily
DSM26151_20010	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
DSM26151_20020	COG1846	Transcriptional regulator
DSM26151_20090	COG1752	Esterase of the alpha-beta hydrolase superfamily
DSM26151_20100	COG0012	GTP binding
DSM26151_20160	COG1322	Protein conserved in bacteria
DSM26151_20200	COG0191	fructose-bisphosphate aldolase activity
DSM26151_20220	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
DSM26151_20230	COG1570	exodeoxyribonuclease VII activity
DSM26151_20240	COG1722	exodeoxyribonuclease VII activity
DSM26151_20270	COG0114	fumarate hydratase activity
DSM26151_20300	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
DSM26151_20320	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
DSM26151_20360	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
DSM26151_20370	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
DSM26151_20390	COG3214	Protein conserved in bacteria
DSM26151_20410	COG1704	LemA family
DSM26151_20450	COG0248	Ppx GppA phosphatase
DSM26151_20480	COG1404	Belongs to the peptidase S8 family
DSM26151_20510	COG0148	phosphopyruvate hydratase activity
DSM26151_20520	COG0124	histidyl-tRNA synthetase
DSM26151_20540	COG1280	lysine exporter protein (LysE YggA)
DSM26151_20550	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
DSM26151_20570	COG0328	RNA-DNA hybrid ribonuclease activity
DSM26151_20600	COG0193	aminoacyl-tRNA hydrolase activity
DSM26151_20610	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
DSM26151_20630	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
DSM26151_20640	COG2149	membrane
DSM26151_20670	COG0318	PFAM AMP-dependent synthetase and ligase
DSM26151_20680	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
DSM26151_20690	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
DSM26151_20720	COG2011	ABC-type metal ion transport system permease component
DSM26151_20730	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
DSM26151_20750	COG0488	(ABC) transporter
DSM26151_20770	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
DSM26151_20780	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
DSM26151_20790	COG0084	hydrolase, TatD family'
DSM26151_20800	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DSM26151_20810	COG1028	Short-chain dehydrogenase reductase Sdr
DSM26151_20810	COG3321	synthase
DSM26151_20810	COG0604	alcohol dehydrogenase
DSM26151_20840	COG2855	membrane
DSM26151_20850	COG1028	Short-chain dehydrogenase reductase Sdr
DSM26151_20850	COG0604	alcohol dehydrogenase
DSM26151_20850	COG3321	synthase
DSM26151_20870	COG1476	TRANSCRIPTIONal
DSM26151_20920	COG1335	isochorismatase
DSM26151_20930	COG2873	o-acetylhomoserine
DSM26151_20940	COG1832	CoA-binding protein
DSM26151_20950	COG0456	acetyltransferase
DSM26151_20960	COG1760	l-serine dehydratase
DSM26151_20990	COG1362	aminopeptidase activity
DSM26151_21000	COG0484	heat shock protein binding
DSM26151_21010	COG2890	protein-(glutamine-N5) methyltransferase activity
DSM26151_21050	COG1331	Highly conserved protein containing a thioredoxin domain
DSM26151_21100	COG1643	Atp-dependent helicase
DSM26151_21140	COG0656	L-ascorbic acid biosynthetic process
DSM26151_21160	COG1960	acyl-CoA dehydrogenase activity
DSM26151_21250	COG4948	Mandelate Racemase Muconate Lactonizing
DSM26151_21260	COG3119	arylsulfatase activity
DSM26151_21300	COG3119	arylsulfatase activity
DSM26151_21330	COG0395	ABC-type sugar transport system, permease component
DSM26151_21340	COG1175	transmembrane transport
DSM26151_21350	COG3250	beta-galactosidase activity
DSM26151_21360	COG1609	Transcriptional regulator
DSM26151_21400	COG1482	cell wall glycoprotein biosynthetic process
DSM26151_21420	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DSM26151_21450	COG0259	pyridoxamine-phosphate oxidase activity
DSM26151_21490	COG1210	Utp--glucose-1-phosphate uridylyltransferase
DSM26151_21520	COG1970	mechanosensitive ion channel activity
DSM26151_21540	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DSM26151_21570	COG1522	sequence-specific DNA binding
DSM26151_21580	COG1793	dna ligase
DSM26151_21590	COG0166	Belongs to the GPI family
DSM26151_21620	COG1388	LysM domain
DSM26151_21620	COG3942	CHAP domain
DSM26151_21640	COG0791	NLP P60 protein
DSM26151_21640	COG3883	PFAM NLP P60 protein
DSM26151_21660	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
DSM26151_21690	COG1278	Cold shock
DSM26151_21720	COG1061	Type III restriction enzyme res subunit
DSM26151_21730	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DSM26151_21730	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DSM26151_21750	COG0745	RESPONSE REGULATOR receiver
DSM26151_21760	COG2205	protein histidine kinase activity
DSM26151_21780	COG0459	protein refolding
DSM26151_21790	COG1278	Cold shock
DSM26151_21820	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DSM26151_21870	COG3842	ATPase activity
DSM26151_21890	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DSM26151_21900	COG0215	cysteine-tRNA ligase activity
DSM26151_21930	COG2197	response regulator
DSM26151_21940	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
DSM26151_21940	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
DSM26151_21970	COG0745	RESPONSE REGULATOR receiver
DSM26151_21980	COG5002	protein histidine kinase activity
DSM26151_22000	COG0588	phosphoglycerate mutase activity
DSM26151_22020	COG0404	The glycine cleavage system catalyzes the degradation of glycine
DSM26151_22030	COG4044	May play a role in the intracellular transport of hydrophobic ligands
DSM26151_22060	COG0745	RESPONSE REGULATOR receiver
DSM26151_22070	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
DSM26151_22110	COG0581	inorganic phosphate transmembrane transporter activity
DSM26151_22120	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
DSM26151_22170	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DSM26151_22190	COG1595	DNA-templated transcription, initiation
DSM26151_22200	COG0586	Pfam SNARE associated Golgi protein
DSM26151_22220	COG2017	converts alpha-aldose to the beta-anomer
DSM26151_22230	COG1349	DNA-binding transcription factor activity
DSM26151_22250	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
DSM26151_22300	COG2089	acid synthase
DSM26151_22340	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
DSM26151_22350	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
DSM26151_22370	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
DSM26151_22390	COG2814	Major facilitator Superfamily
DSM26151_22470	COG0395	ABC-type sugar transport system, permease component
DSM26151_22480	COG1175	transmembrane transport
DSM26151_22500	COG1940	carbohydrate kinase activity
DSM26151_22510	COG2217	Heavy metal translocating P-type atpase
DSM26151_22520	COG0538	isocitrate dehydrogenase activity
DSM26151_22560	COG2197	response regulator
DSM26151_22580	COG1132	(ABC) transporter
DSM26151_22650	COG0395	ABC-type sugar transport system, permease component
DSM26151_22660	COG1175	transmembrane transport
DSM26151_22680	COG1834	amidinotransferase
DSM26151_22700	COG0138	bifunctional purine biosynthesis protein purh
DSM26151_22780	COG0045	succinate-CoA ligase (ADP-forming) activity
DSM26151_22800	COG3401	FG-GAP repeat protein
DSM26151_22820	COG2197	response regulator
DSM26151_22830	COG4585	Histidine kinase
DSM26151_22880	COG0584	glycerophosphoryl diester phosphodiesterase
DSM26151_22900	COG4941	Belongs to the sigma-70 factor family
DSM26151_22910	COG3795	YCII-related domain
DSM26151_22940	COG0518	GMP synthase (glutamine-hydrolyzing) activity
DSM26151_22940	COG0519	Catalyzes the synthesis of GMP from XMP
DSM26151_22960	COG1309	transcriptional regulator
DSM26151_22990	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
DSM26151_23000	COG0516	GMP reductase activity
DSM26151_23010	COG0488	(ABC) transporter
DSM26151_23100	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
DSM26151_23150	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
DSM26151_23180	COG0802	atpase or kinase
DSM26151_23190	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
DSM26151_23200	COG0736	holo-[acyl-carrier-protein] synthase activity
DSM26151_23210	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
DSM26151_23220	COG1072	(Pantothenic acid kinase))
DSM26151_23230	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DSM26151_23240	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
DSM26151_23250	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
DSM26151_23260	COG0101	tRNA pseudouridine synthase activity
DSM26151_23270	COG0203	ribosomal protein L17
DSM26151_23280	COG0202	RNA polymerase activity
DSM26151_23290	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
DSM26151_23300	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
DSM26151_23310	COG0257	Belongs to the bacterial ribosomal protein bL36 family
DSM26151_23320	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
DSM26151_23330	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DSM26151_23350	COG0563	adenylate kinase activity
DSM26151_23370	COG0200	Binds to the 23S rRNA
DSM26151_23380	COG1841	ribosomal large subunit assembly
DSM26151_23390	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
DSM26151_23400	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
DSM26151_23410	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
DSM26151_23420	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
DSM26151_23430	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
DSM26151_23440	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
DSM26151_23450	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
DSM26151_23460	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
DSM26151_23470	COG0255	Belongs to the universal ribosomal protein uL29 family
DSM26151_23480	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
DSM26151_23490	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
DSM26151_23500	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
DSM26151_23510	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
DSM26151_23520	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
DSM26151_23530	COG0089	rRNA binding
DSM26151_23540	COG0088	Forms part of the polypeptide exit tunnel
DSM26151_23550	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
DSM26151_23560	COG0051	transcription antitermination factor activity, RNA binding
DSM26151_23590	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
DSM26151_23600	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
DSM26151_23610	COG0049	tRNA binding
DSM26151_23620	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
DSM26151_23760	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
DSM26151_23770	COG0085	RNA polymerase activity
DSM26151_23870	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
DSM26151_23960	COG0513	Belongs to the DEAD box helicase family
DSM26151_24020	COG0519	Catalyzes the synthesis of GMP from XMP
DSM26151_24020	COG0518	GMP synthase (glutamine-hydrolyzing) activity
DSM26151_24030	COG2261	transglycosylase associated protein
DSM26151_24040	COG2501	S4 domain
DSM26151_24070	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
DSM26151_24100	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
DSM26151_24130	COG3655	Transcriptional regulator
DSM26151_24200	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
DSM26151_24210	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
DSM26151_24260	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
DSM26151_24270	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
DSM26151_24280	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
DSM26151_24290	COG0302	gtp cyclohydrolase
DSM26151_24300	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DSM26151_24330	COG0037	tRNA processing
DSM26151_24340	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
DSM26151_24350	COG1196	nuclear chromosome segregation
DSM26151_24350	COG0739	heme binding
DSM26151_24350	COG0741	lytic transglycosylase activity
DSM26151_24480	COG3550	peptidyl-serine autophosphorylation
DSM26151_24500	COG0322	excinuclease ABC activity
DSM26151_24590	COG0697	spore germination
DSM26151_24630	COG0039	L-malate dehydrogenase activity
DSM26151_24670	COG0514	ATP-dependent DNA helicase (RecQ)
DSM26151_24710	COG0737	Belongs to the 5'-nucleotidase family
DSM26151_24750	COG0667	Aldo Keto reductase
DSM26151_24820	COG0730	response to heat
DSM26151_24870	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
DSM26151_24910	COG3119	arylsulfatase activity
DSM26151_24920	COG3119	arylsulfatase activity
DSM26151_25010	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DSM26151_25060	COG4122	O-methyltransferase activity
DSM26151_25160	COG3328	transposase activity
DSM26151_25170	COG0494	nUDIX hydrolase
DSM26151_25190	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
DSM26151_25210	COG3328	transposase activity
DSM26151_25220	COG1690	Belongs to the RtcB family
DSM26151_25260	COG1690	Belongs to the RtcB family
DSM26151_25380	COG2197	response regulator
DSM26151_25420	COG0352	thiamine-phosphate diphosphorylase activity
DSM26151_25430	COG0351	phosphomethylpyrimidine kinase
DSM26151_25430	COG0352	thiamine-phosphate diphosphorylase activity
DSM26151_25430	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
DSM26151_25440	COG0477	Major facilitator Superfamily
DSM26151_25500	COG4977	sequence-specific DNA binding
DSM26151_25510	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DSM26151_25550	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DSM26151_25560	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DSM26151_25570	COG4129	membrane
DSM26151_25580	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DSM26151_25600	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
DSM26151_25630	COG1028	Short-chain dehydrogenase reductase Sdr
DSM26151_25670	COG0154	amidase activity
DSM26151_25680	COG2957	Belongs to the agmatine deiminase family
DSM26151_25770	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DSM26151_25790	COG2124	cytochrome p450
DSM26151_25830	COG2111	Na H antiporter
DSM26151_25830	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
DSM26151_25840	COG1006	Multisubunit Na H antiporter MnhC subunit
DSM26151_25850	COG0651	ATP synthesis coupled electron transport
DSM26151_25880	COG1320	monovalent cation:proton antiporter activity
DSM26151_25890	COG1024	Enoyl-CoA hydratase
DSM26151_25900	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
DSM26151_25910	COG2151	metal-sulfur cluster biosynthetic enzyme
DSM26151_25920	COG3396	Phenylacetate-CoA oxygenase
DSM26151_25930	COG3460	Phenylacetate-CoA oxygenase
DSM26151_25940	COG3396	Phenylacetate-CoA oxygenase
DSM26151_25950	COG2050	protein possibly involved in aromatic compounds catabolism
DSM26151_25970	COG1309	transcriptional regulator
DSM26151_26000	COG1131	(ABC) transporter
DSM26151_26010	COG1309	transcriptional regulator
DSM26151_26030	COG0514	ATP-dependent DNA helicase (RecQ)
DSM26151_26040	COG2030	dehydratase
DSM26151_26040	COG1012	belongs to the aldehyde dehydrogenase family
DSM26151_26050	COG1250	3-hydroxyacyl-CoA dehydrogenase
DSM26151_26070	COG0183	Belongs to the thiolase family
DSM26151_26080	COG0513	Belongs to the DEAD box helicase family
DSM26151_26160	COG0741	lytic transglycosylase activity
DSM26151_26160	COG1196	nuclear chromosome segregation
DSM26151_26160	COG0739	heme binding
DSM26151_26170	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
DSM26151_26180	COG1228	amidohydrolase
DSM26151_26210	COG3328	transposase activity
DSM26151_26260	COG1136	(ABC) transporter
DSM26151_26320	COG2732	(Barnase) inhibitor
DSM26151_26360	COG3311	Transcriptional regulator
DSM26151_26390	COG4115	mRNA cleavage
DSM26151_26510	COG2161	toxin-antitoxin pair type II binding
DSM26151_26550	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
DSM26151_26570	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
DSM26151_26590	COG0314	molybdopterin synthase activity
DSM26151_26600	COG0521	Mo-molybdopterin cofactor biosynthetic process
DSM26151_26600	COG0315	cyclic pyranopterin monophosphate synthase activity
DSM26151_26650	COG0725	ABC transporter, periplasmic molybdate-binding protein
DSM26151_26720	COG2188	Transcriptional regulator
DSM26151_26740	COG0303	'Molybdopterin
DSM26151_26760	COG0746	molybdenum cofactor guanylyltransferase activity
DSM26151_26770	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DSM26151_26780	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DSM26151_26790	COG2364	Membrane
DSM26151_26850	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
DSM26151_26860	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
DSM26151_26910	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
DSM26151_26940	COG2050	protein possibly involved in aromatic compounds catabolism
DSM26151_26990	COG0151	Belongs to the GarS family
DSM26151_27000	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
DSM26151_27010	COG2514	catechol 2,3-dioxygenase activity
DSM26151_27040	COG3483	tryptophan 2,3-dioxygenase activity
DSM26151_27090	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
DSM26151_27100	COG0047	phosphoribosylformylglycinamidine synthase activity
DSM26151_27110	COG0047	phosphoribosylformylglycinamidine synthase activity
DSM26151_27170	COG1262	PFAM Formylglycine-generating sulfatase enzyme
DSM26151_27190	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
DSM26151_27210	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
DSM26151_27270	COG1605	Chorismate mutase
DSM26151_27270	COG0287	Prephenate dehydrogenase
DSM26151_27320	COG1131	(ABC) transporter
DSM26151_27350	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DSM26151_27370	COG3275	phosphorelay sensor kinase activity
DSM26151_27380	COG3279	Response regulator of the LytR AlgR family
DSM26151_27400	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DSM26151_27430	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
DSM26151_27450	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
DSM26151_27460	COG0137	argininosuccinate synthase activity
DSM26151_27490	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DSM26151_27560	COG1321	iron dependent repressor
DSM26151_27590	COG1177	transmembrane transport
DSM26151_27600	COG1176	ABC-type spermidine putrescine transport system, permease component I
DSM26151_27610	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
DSM26151_27620	COG3842	ATPase activity
DSM26151_27680	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DSM26151_27700	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
DSM26151_27750	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
DSM26151_27770	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
DSM26151_27780	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
DSM26151_27790	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DSM26151_27800	COG1116	anion transmembrane transporter activity
DSM26151_27810	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DSM26151_27830	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
DSM26151_27890	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DSM26151_27910	COG0391	Required for morphogenesis under gluconeogenic growth conditions
DSM26151_28000	COG0251	oxidation-reduction process
DSM26151_28010	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DSM26151_28020	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DSM26151_28030	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
DSM26151_28040	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DSM26151_28080	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DSM26151_28090	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
DSM26151_28130	COG0405	Gamma-glutamyltransferase
DSM26151_28140	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DSM26151_28150	COG1920	GTP binding
DSM26151_28160	COG0778	Nitroreductase
DSM26151_28160	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
DSM26151_28170	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DSM26151_28190	COG0778	Nitroreductase
DSM26151_28190	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
DSM26151_28250	COG0300	oxidoreductase activity
DSM26151_28280	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DSM26151_28320	COG1028	Short-chain dehydrogenase reductase Sdr
DSM26151_28360	COG3842	ATPase activity
DSM26151_28390	COG0640	Transcriptional regulator
DSM26151_28430	COG1063	alcohol dehydrogenase
DSM26151_28440	COG2272	Belongs to the type-B carboxylesterase lipase family
DSM26151_28450	COG0477	Major facilitator Superfamily
DSM26151_28460	COG0542	response to heat
DSM26151_28510	COG0659	secondary active sulfate transmembrane transporter activity
DSM26151_28520	COG0628	permease
DSM26151_28540	COG2015	COG2015, Alkyl sulfatase and related hydrolases
DSM26151_28610	COG0628	permease
DSM26151_28620	COG3119	arylsulfatase activity
DSM26151_28650	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
DSM26151_28680	COG0640	Transcriptional regulator
DSM26151_28710	COG0789	Transcriptional regulator
DSM26151_28720	COG0484	heat shock protein binding
DSM26151_28730	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
DSM26151_28740	COG0443	Heat shock 70 kDa protein
DSM26151_28780	COG0820	rRNA (adenine-C2-)-methyltransferase activity
DSM26151_28850	COG0175	sulfate reduction
DSM26151_28870	COG2895	sulfate adenylyltransferase (ATP) activity
DSM26151_28870	COG0529	Catalyzes the synthesis of activated sulfate
DSM26151_28900	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DSM26151_28910	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
DSM26151_28910	COG1648	precorrin-2 dehydrogenase activity
DSM26151_28970	COG0297	glycogen (starch) synthase activity
DSM26151_28980	COG0438	transferase activity, transferring glycosyl groups
DSM26151_28990	COG0438	transferase activity, transferring glycosyl groups
DSM26151_29020	COG0438	transferase activity, transferring glycosyl groups
DSM26151_29070	COG0438	transferase activity, transferring glycosyl groups
DSM26151_29090	COG0297	glycogen (starch) synthase activity
DSM26151_29130	COG1215	transferase activity, transferring glycosyl groups
DSM26151_29150	COG1132	(ABC) transporter
DSM26151_29180	COG0717	Belongs to the dCTP deaminase family
DSM26151_29230	COG1172	Belongs to the binding-protein-dependent transport system permease family
DSM26151_29240	COG1129	ABC transporter
DSM26151_29260	COG2197	response regulator
DSM26151_29280	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DSM26151_29290	COG0673	inositol 2-dehydrogenase activity
DSM26151_29310	COG0765	amino acid transport
DSM26151_29320	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DSM26151_29400	COG0697	spore germination
DSM26151_29410	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DSM26151_29420	COG0628	permease
DSM26151_29430	COG3119	arylsulfatase activity
DSM26151_29450	COG2909	trisaccharide binding
DSM26151_29470	COG0446	pyridine nucleotide-disulphide oxidoreductase
DSM26151_29490	COG0531	amino acid
DSM26151_29530	COG0733	neurotransmitter:sodium symporter activity
DSM26151_29600	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
DSM26151_29630	COG0776	regulation of translation
DSM26151_29640	COG1278	Cold shock
DSM26151_29660	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
DSM26151_29670	COG0267	Belongs to the bacterial ribosomal protein bL33 family
DSM26151_29680	COG0227	Belongs to the bacterial ribosomal protein bL28 family
DSM26151_29700	COG0076	glutamate decarboxylase activity
DSM26151_29760	COG0701	Predicted permease
DSM26151_29790	COG1108	ABC-type Mn2 Zn2 transport systems permease components
DSM26151_29800	COG1121	(ABC) transporter
DSM26151_29840	COG0508	dehydrogenase complex catalyzes the overall conversion of
DSM26151_29850	COG0022	dehydrogenase e1 component
DSM26151_29870	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DSM26151_29880	COG1950	PFAM Membrane protein of
DSM26151_29920	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DSM26151_29930	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
DSM26151_29960	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
DSM26151_29970	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
DSM26151_30010	COG0305	Participates in initiation and elongation during chromosome replication
DSM26151_30020	COG0359	binds to the 23S rRNA
DSM26151_30030	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
DSM26151_30050	COG0360	Binds together with S18 to 16S ribosomal RNA
DSM26151_30070	COG0617	tRNA 3'-terminal CCA addition
DSM26151_30100	COG0492	ferredoxin-NADP+ reductase activity
DSM26151_30110	COG3118	belongs to the thioredoxin family
DSM26151_30120	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DSM26151_30130	COG1181	Belongs to the D-alanine--D-alanine ligase family
DSM26151_30150	COG1192	Involved in chromosome partitioning
DSM26151_30160	COG1619	proteins homologs of microcin C7 resistance protein MccF
DSM26151_30170	COG0357	Ribosomal RNA small subunit methyltransferase G
DSM26151_30190	COG0706	membrane insertase activity
DSM26151_30200	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
DSM26151_30210	COG0594	ribonuclease P activity
DSM26151_30220	COG0230	Belongs to the bacterial ribosomal protein bL34 family