locus-tag	class	description
ET445_00010	COG1929	Belongs to the glycerate kinase type-1 family
ET445_00020	COG4552	Acetyltransferase involved in intracellular survival and related
ET445_00035	COG4214	carbohydrate transport
ET445_00055	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
ET445_00120	COG2226	methyltransferase
ET445_00135	COG4702	Belongs to the UPF0303 family
ET445_00190	COG1247	-acetyltransferase
ET445_00205	COG1793	dna ligase
ET445_00225	COG0667	Aldo Keto reductase
ET445_00230	COG1309	transcriptional regulator
ET445_00235	COG0300	oxidoreductase activity
ET445_00245	COG4989	oxidoreductase activity
ET445_00270	COG1120	ATPase activity
ET445_00275	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ET445_00280	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ET445_00305	COG1132	(ABC) transporter
ET445_00345	COG2837	iron assimilation
ET445_00400	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ET445_00405	COG1175	transmembrane transport
ET445_00410	COG0395	ABC-type sugar transport system, permease component
ET445_00415	COG1653	transport
ET445_00430	COG3250	beta-galactosidase activity
ET445_00435	COG0542	response to heat
ET445_00540	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
ET445_00550	COG0596	Alpha beta hydrolase
ET445_00555	COG2197	response regulator
ET445_00565	COG0488	(ABC) transporter
ET445_00630	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
ET445_00640	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ET445_00645	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ET445_00655	COG0596	Alpha beta hydrolase
ET445_00675	COG0477	Major facilitator Superfamily
ET445_00680	COG2814	Major facilitator Superfamily
ET445_00695	COG1028	Short-chain dehydrogenase reductase Sdr
ET445_00710	COG0640	Transcriptional regulator
ET445_00715	COG1846	Transcriptional regulator
ET445_00720	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ET445_00760	COG1053	succinate dehydrogenase
ET445_00765	COG0251	oxidation-reduction process
ET445_00780	COG1396	sequence-specific DNA binding
ET445_00805	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ET445_00815	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ET445_00820	COG1780	Probably involved in ribonucleotide reductase function
ET445_00845	COG1172	Belongs to the binding-protein-dependent transport system permease family
ET445_00855	COG1609	Transcriptional regulator
ET445_00875	COG0531	amino acid
ET445_00900	COG0668	transmembrane transport
ET445_00905	COG0840	transmembrane signaling receptor activity
ET445_00910	COG1132	(ABC) transporter
ET445_00915	COG0395	ABC-type sugar transport system, permease component
ET445_00915	COG0395	ABC-type sugar transport system, permease component
ET445_00920	COG1175	transmembrane transport
ET445_00925	COG1653	transport
ET445_00930	COG1609	Transcriptional regulator
ET445_00935	COG2814	Major facilitator Superfamily
ET445_00940	COG1846	Transcriptional regulator
ET445_00950	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
ET445_00955	COG0477	Major facilitator Superfamily
ET445_00970	COG2205	protein histidine kinase activity
ET445_00975	COG0745	RESPONSE REGULATOR receiver
ET445_00985	COG1136	(ABC) transporter
ET445_01035	COG0631	protein serine/threonine phosphatase activity
ET445_01055	COG0714	Associated with various cellular activities
ET445_01125	COG1404	Belongs to the peptidase S8 family
ET445_01170	COG1090	epimerase
ET445_01235	COG2211	Major facilitator Superfamily
ET445_01270	COG1126	abc transporter atp-binding protein
ET445_01275	COG0765	amino acid transport
ET445_01280	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ET445_01290	COG1012	belongs to the aldehyde dehydrogenase family
ET445_01300	COG1254	Belongs to the acylphosphatase family
ET445_01305	COG1028	Short-chain dehydrogenase reductase Sdr
ET445_01310	COG1309	transcriptional regulator
ET445_01330	COG1960	acyl-CoA dehydrogenase activity
ET445_01335	COG0081	regulation of translation
ET445_01340	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
ET445_01375	COG0232	Belongs to the dGTPase family. Type 2 subfamily
ET445_01390	COG0436	Aminotransferase
ET445_01395	COG0583	DNA-binding transcription factor activity
ET445_01405	COG3491	Belongs to the iron ascorbate-dependent oxidoreductase family
ET445_01415	COG3795	YCII-related domain
ET445_01425	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
ET445_01440	COG3850	Histidine kinase
ET445_01445	COG2197	response regulator
ET445_01450	COG3397	chitin binding
ET445_01455	COG3397	chitin binding
ET445_01460	COG0531	amino acid
ET445_01465	COG2197	response regulator
ET445_01485	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
ET445_01490	COG0812	UDP-N-acetylmuramate dehydrogenase activity
ET445_01500	COG2030	dehydratase
ET445_01510	COG0438	transferase activity, transferring glycosyl groups
ET445_01515	COG0438	transferase activity, transferring glycosyl groups
ET445_01520	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
ET445_01610	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
ET445_01620	COG0484	heat shock protein binding
ET445_01630	COG1793	dna ligase
ET445_01630	COG3285	dna ligase
ET445_01685	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ET445_01695	COG0395	ABC-type sugar transport system, permease component
ET445_01705	COG2182	Extracellular solute-binding protein
ET445_01730	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
ET445_01740	COG1349	DNA-binding transcription factor activity
ET445_01760	COG3833	ABC-type maltose transport systems, permease component
ET445_01765	COG1175	transmembrane transport
ET445_01770	COG2182	Extracellular solute-binding protein
ET445_01775	COG0366	Alpha amylase catalytic
ET445_01780	COG0739	heme binding
ET445_01790	COG3415	Transposase
ET445_01790	COG2801	Transposase and inactivated derivatives
ET445_01810	COG1609	Transcriptional regulator
ET445_01820	COG1666	GTP binding
ET445_01845	COG0142	geranyltranstransferase activity
ET445_01850	COG2226	methyltransferase
ET445_01865	COG2326	polyphosphate kinase activity
ET445_01870	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
ET445_01895	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
ET445_01910	COG1410	methionine synthase
ET445_01910	COG0646	methionine synthase
ET445_01915	COG4948	Mandelate Racemase Muconate Lactonizing
ET445_01930	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ET445_01940	COG0785	Cytochrome C biogenesis protein
ET445_01945	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ET445_01950	COG0406	alpha-ribazole phosphatase activity
ET445_01960	COG1262	PFAM Formylglycine-generating sulfatase enzyme
ET445_01985	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
ET445_01990	COG0569	domain protein
ET445_01995	COG1131	(ABC) transporter
ET445_02000	COG3559	Exporter of polyketide antibiotics
ET445_02020	COG0246	Mannitol dehydrogenase
ET445_02030	COG1609	Transcriptional regulator
ET445_02035	COG1904	glucuronate isomerase
ET445_02040	COG4948	Mandelate Racemase Muconate Lactonizing
ET445_02085	COG0395	ABC-type sugar transport system, permease component
ET445_02090	COG3458	cephalosporin-C deacetylase activity
ET445_02095	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
ET445_02100	COG3525	Glycosyl hydrolase, family 20, catalytic domain
ET445_02115	COG0518	GMP synthase (glutamine-hydrolyzing) activity
ET445_02115	COG0519	Catalyzes the synthesis of GMP from XMP
ET445_02125	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
ET445_02135	COG2890	protein-(glutamine-N5) methyltransferase activity
ET445_02140	COG2197	response regulator
ET445_02195	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ET445_02200	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ET445_02205	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ET445_02220	COG0395	ABC-type sugar transport system, permease component
ET445_02225	COG4209	transmembrane transport
ET445_02235	COG0366	Alpha amylase catalytic
ET445_02265	COG1028	Short-chain dehydrogenase reductase Sdr
ET445_02285	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
ET445_02310	COG2909	trisaccharide binding
ET445_02315	COG3119	arylsulfatase activity
ET445_02320	COG1262	PFAM Formylglycine-generating sulfatase enzyme
ET445_02325	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
ET445_02330	COG1414	Transcriptional regulator
ET445_02390	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
ET445_02390	COG3608	succinylglutamate desuccinylase aspartoacylase
ET445_02410	COG1316	TRANSCRIPTIONal
ET445_02420	COG1316	TRANSCRIPTIONal
ET445_02425	COG0561	phosphatase activity
ET445_02430	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
ET445_02435	COG1597	lipid kinase activity
ET445_02450	COG0077	Prephenate dehydratase
ET445_02455	COG2733	membrane
ET445_02475	COG1876	peptidase activity
ET445_02490	COG0395	ABC-type sugar transport system, permease component
ET445_02505	COG3550	peptidyl-serine autophosphorylation
ET445_02540	COG2188	Transcriptional regulator
ET445_02545	COG2189	Belongs to the N(4) N(6)-methyltransferase family
ET445_02555	COG0095	Lipoate-protein ligase
ET445_02565	COG0366	Alpha amylase catalytic
ET445_02570	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ET445_02585	COG1082	Xylose isomerase domain protein TIM barrel
ET445_02590	COG1063	alcohol dehydrogenase
ET445_02595	COG0395	ABC-type sugar transport system, permease component
ET445_02600	COG1175	transmembrane transport
ET445_02620	COG1305	Transglutaminase-like
ET445_02640	COG2814	Major facilitator Superfamily
ET445_02645	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
ET445_02655	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ET445_02665	COG0693	protein deglycase activity
ET445_02680	COG2188	Transcriptional regulator
ET445_02705	COG1940	carbohydrate kinase activity
ET445_02715	COG2814	Major facilitator Superfamily
ET445_02720	COG3104	oligopeptide transport
ET445_02750	COG1725	Transcriptional regulator
ET445_02760	COG1725	Transcriptional regulator
ET445_02765	COG0569	domain protein
ET445_02765	COG0189	ligase activity
ET445_02770	COG4067	protein conserved in archaea
ET445_02770	COG0189	ligase activity
ET445_02775	COG1012	belongs to the aldehyde dehydrogenase family
ET445_02840	COG1733	regulation of RNA biosynthetic process
ET445_02865	COG1309	transcriptional regulator
ET445_02895	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
ET445_02900	COG2079	MmgE PrpD family protein
ET445_02910	COG0822	iron-sulfur transferase activity
ET445_02915	COG1024	Enoyl-CoA hydratase
ET445_02920	COG1280	lysine exporter protein (LysE YggA)
ET445_02955	COG1131	(ABC) transporter
ET445_02985	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
ET445_02990	COG0113	porphobilinogen synthase activity
ET445_03040	COG0644	oxidoreductase
ET445_03085	COG0423	glycine-tRNA ligase activity
ET445_03095	COG0477	Major facilitator Superfamily
ET445_03120	COG3590	peptidase
ET445_03125	COG3304	Inner membrane component domain
ET445_03135	COG0534	Mate efflux family protein
ET445_03150	COG0300	oxidoreductase activity
ET445_03155	COG0156	8-amino-7-oxononanoate synthase activity
ET445_03160	COG1063	alcohol dehydrogenase
ET445_03180	COG1309	transcriptional regulator
ET445_03200	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
ET445_03205	COG1028	Short-chain dehydrogenase reductase Sdr
ET445_03210	COG0546	phosphoglycolate phosphatase activity
ET445_03235	COG0477	Major facilitator Superfamily
ET445_03250	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
ET445_03270	COG0386	Belongs to the glutathione peroxidase family
ET445_03275	COG2197	response regulator
ET445_03295	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ET445_03315	COG2837	iron assimilation
ET445_03320	COG2822	iron ion transport
ET445_03365	COG1846	Transcriptional regulator
ET445_03375	COG3591	Belongs to the peptidase S1B family
ET445_03375	COG1864	DNA RNA non-specific endonuclease
ET445_03395	COG3458	cephalosporin-C deacetylase activity
ET445_03430	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
ET445_03435	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
ET445_03450	COG0640	Transcriptional regulator
ET445_03460	COG1053	succinate dehydrogenase
ET445_03465	COG1028	Short-chain dehydrogenase reductase Sdr
ET445_03510	COG0492	ferredoxin-NADP+ reductase activity
ET445_03535	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
ET445_03550	COG0667	Aldo Keto reductase
ET445_03560	COG1595	DNA-templated transcription, initiation
ET445_03565	COG1846	Transcriptional regulator
ET445_03570	COG0596	Alpha beta hydrolase
ET445_03575	COG1595	DNA-templated transcription, initiation
ET445_03610	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
ET445_03615	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
ET445_03625	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ET445_03665	COG0598	Magnesium transport protein CorA
ET445_03700	COG3328	transposase activity
ET445_03740	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
ET445_03750	COG3328	transposase activity
ET445_03785	COG1716	ATPase activity
ET445_03805	COG0515	serine threonine protein kinase
ET445_03810	COG0515	serine threonine protein kinase
ET445_03820	COG3764	Sortase (surface protein transpeptidase)
ET445_03830	COG0457	Tetratricopeptide repeat
ET445_03830	COG0705	Rhomboid family
ET445_03850	COG0494	nUDIX hydrolase
ET445_03855	COG0667	Aldo Keto reductase
ET445_03870	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
ET445_03895	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
ET445_03900	COG0187	DNA topoisomerase II activity
ET445_03905	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
ET445_03910	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
ET445_03915	COG0592	DNA-directed DNA polymerase activity
ET445_03920	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
ET445_03925	COG0230	Belongs to the bacterial ribosomal protein bL34 family
ET445_03930	COG0594	ribonuclease P activity
ET445_03935	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
ET445_03940	COG0706	membrane insertase activity
ET445_03950	COG0357	Ribosomal RNA small subunit methyltransferase G
ET445_03955	COG1192	Involved in chromosome partitioning
ET445_03975	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ET445_03980	COG3118	belongs to the thioredoxin family
ET445_04010	COG0617	tRNA 3'-terminal CCA addition
ET445_04015	COG0360	Binds together with S18 to 16S ribosomal RNA
ET445_04025	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
ET445_04030	COG0359	binds to the 23S rRNA
ET445_04040	COG1028	Short-chain dehydrogenase reductase Sdr
ET445_04115	COG0667	Aldo Keto reductase
ET445_04125	COG0534	Mate efflux family protein
ET445_04135	COG1132	(ABC) transporter
ET445_04140	COG1132	(ABC) transporter
ET445_04145	COG1725	Transcriptional regulator
ET445_04165	COG0601	transmembrane transport
ET445_04170	COG0747	negative chemotaxis
ET445_04205	COG1940	carbohydrate kinase activity
ET445_04215	COG1175	transmembrane transport
ET445_04220	COG0395	ABC-type sugar transport system, permease component
ET445_04265	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
ET445_04270	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
ET445_04290	COG1950	PFAM Membrane protein of
ET445_04295	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ET445_04315	COG2873	o-acetylhomoserine
ET445_04335	COG1121	(ABC) transporter
ET445_04340	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ET445_04355	COG0227	Belongs to the bacterial ribosomal protein bL28 family
ET445_04360	COG0267	Belongs to the bacterial ribosomal protein bL33 family
ET445_04365	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
ET445_04370	COG0776	regulation of translation
ET445_04375	COG3336	cytochrome c oxidase
ET445_04385	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
ET445_04390	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
ET445_04405	COG0257	Belongs to the bacterial ribosomal protein bL36 family
ET445_04430	COG0717	Belongs to the dCTP deaminase family
ET445_04480	COG4608	Belongs to the ABC transporter superfamily
ET445_04485	COG0601	transmembrane transport
ET445_04490	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ET445_04495	COG0444	Belongs to the ABC transporter superfamily
ET445_04505	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
ET445_04505	COG1648	precorrin-2 dehydrogenase activity
ET445_04510	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ET445_04515	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
ET445_04535	COG0175	sulfate reduction
ET445_04540	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ET445_04570	COG3655	Transcriptional regulator
ET445_04590	COG0701	Predicted permease
ET445_04595	COG0443	Heat shock 70 kDa protein
ET445_04600	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
ET445_04605	COG0484	heat shock protein binding
ET445_04610	COG0789	Transcriptional regulator
ET445_04625	COG2813	Specifically methylates the guanine in position
ET445_04630	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
ET445_04645	COG2015	COG2015, Alkyl sulfatase and related hydrolases
ET445_04655	COG0628	permease
ET445_04680	COG3424	synthase
ET445_04685	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
ET445_04720	COG0542	response to heat
ET445_04730	COG2272	Belongs to the type-B carboxylesterase lipase family
ET445_04735	COG0477	Major facilitator Superfamily
ET445_04770	COG4152	abc transporter atp-binding protein
ET445_04780	COG0662	Cupin 2, conserved barrel domain protein
ET445_04785	COG2197	response regulator
ET445_04800	COG0659	secondary active sulfate transmembrane transporter activity
ET445_04850	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ET445_04855	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ET445_04865	COG1116	anion transmembrane transporter activity
ET445_04870	COG0300	oxidoreductase activity
ET445_04875	COG0346	lactoylglutathione lyase activity
ET445_04890	COG0778	Nitroreductase
ET445_04890	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
ET445_04895	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ET445_04900	COG1920	GTP binding
ET445_04905	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ET445_04925	COG1120	ATPase activity
ET445_04930	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ET445_04955	COG0391	Required for morphogenesis under gluconeogenic growth conditions
ET445_04970	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
ET445_04980	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ET445_04985	COG1116	anion transmembrane transporter activity
ET445_04990	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ET445_04995	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
ET445_05000	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
ET445_05025	COG3340	Belongs to the peptidase S51 family
ET445_05030	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
ET445_05040	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
ET445_05055	COG0747	negative chemotaxis
ET445_05115	COG0492	ferredoxin-NADP+ reductase activity
ET445_05125	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ET445_05135	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
ET445_05135	COG2066	Belongs to the glutaminase family
ET445_05160	COG0598	Magnesium transport protein CorA
ET445_05180	COG0137	argininosuccinate synthase activity
ET445_05195	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
ET445_05210	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ET445_05225	COG3275	phosphorelay sensor kinase activity
ET445_05235	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ET445_05240	COG0477	Major facilitator Superfamily
ET445_05245	COG1335	isochorismatase
ET445_05265	COG0697	spore germination
ET445_05270	COG2188	Transcriptional regulator
ET445_05275	COG1131	(ABC) transporter
ET445_05285	COG0287	Prephenate dehydrogenase
ET445_05285	COG1605	Chorismate mutase
ET445_05330	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
ET445_05335	COG0318	PFAM AMP-dependent synthetase and ligase
ET445_05345	COG1053	succinate dehydrogenase
ET445_05350	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
ET445_05355	COG0166	Belongs to the GPI family
ET445_05370	COG0471	metal ion transport
ET445_05380	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
ET445_05390	COG3537	Alpha-1,2-mannosidase
ET445_05395	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
ET445_05405	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
ET445_05425	COG3483	tryptophan 2,3-dioxygenase activity
ET445_05435	COG2514	catechol 2,3-dioxygenase activity
ET445_05440	COG3548	integral membrane protein
ET445_05445	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
ET445_05450	COG4558	Periplasmic binding protein
ET445_05455	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ET445_05460	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
ET445_05490	COG0151	Belongs to the GarS family
ET445_05560	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
ET445_05585	COG1802	Transcriptional regulator
ET445_05620	COG0789	Transcriptional regulator
ET445_05645	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ET445_05670	COG2217	Heavy metal translocating P-type atpase
ET445_05685	COG1228	amidohydrolase
ET445_05690	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
ET445_05695	COG1196	nuclear chromosome segregation
ET445_05695	COG0741	lytic transglycosylase activity
ET445_05695	COG0739	heme binding
ET445_05710	COG0586	Pfam SNARE associated Golgi protein
ET445_05720	COG0456	acetyltransferase
ET445_05750	COG1028	Short-chain dehydrogenase reductase Sdr
ET445_05760	COG0183	Belongs to the thiolase family
ET445_05765	COG1024	Enoyl-CoA hydratase
ET445_05770	COG1250	3-hydroxyacyl-CoA dehydrogenase
ET445_05775	COG1012	belongs to the aldehyde dehydrogenase family
ET445_05775	COG2030	dehydratase
ET445_05785	COG0514	ATP-dependent DNA helicase (RecQ)
ET445_05810	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ET445_05815	COG1309	transcriptional regulator
ET445_05825	COG2050	protein possibly involved in aromatic compounds catabolism
ET445_05830	COG3396	Phenylacetate-CoA oxygenase
ET445_05835	COG3460	Phenylacetate-CoA oxygenase
ET445_05840	COG2151	metal-sulfur cluster biosynthetic enzyme
ET445_05845	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ET445_05860	COG2212	antiporter activity
ET445_05880	COG2111	Na H antiporter
ET445_05880	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
ET445_05890	COG0545	Peptidyl-prolyl cis-trans isomerase
ET445_05895	COG0530	calcium, potassium:sodium antiporter activity
ET445_05915	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
ET445_05920	COG1122	ATPase activity
ET445_05930	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ET445_05955	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ET445_05985	COG2957	Belongs to the agmatine deiminase family
ET445_06010	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
ET445_06035	COG1250	3-hydroxyacyl-CoA dehydrogenase
ET445_06035	COG1024	Enoyl-CoA hydratase
ET445_06045	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ET445_06055	COG1119	ATPase activity
ET445_06065	COG4977	sequence-specific DNA binding
ET445_06080	COG0740	serine-type endopeptidase activity
ET445_06085	COG0740	serine-type endopeptidase activity
ET445_06110	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
ET445_06115	COG0352	thiamine-phosphate diphosphorylase activity
ET445_06115	COG0351	phosphomethylpyrimidine kinase
ET445_06115	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
ET445_06120	COG0352	thiamine-phosphate diphosphorylase activity
ET445_06125	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
ET445_06170	COG0494	nUDIX hydrolase
ET445_06225	COG4941	Belongs to the sigma-70 factor family
ET445_06255	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
ET445_06270	COG2197	response regulator
ET445_06275	COG4585	Histidine kinase
ET445_06295	COG1620	l-lactate permease
ET445_06305	COG2197	response regulator
ET445_06320	COG1960	acyl-CoA dehydrogenase activity
ET445_06340	COG0395	ABC-type sugar transport system, permease component
ET445_06345	COG1472	Belongs to the glycosyl hydrolase 3 family
ET445_06350	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
ET445_06355	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
ET445_06360	COG1737	Transcriptional regulator
ET445_06370	COG0730	response to heat
ET445_06375	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ET445_06395	COG0656	L-ascorbic acid biosynthetic process
ET445_06400	COG2814	Major facilitator Superfamily
ET445_06405	COG1846	Transcriptional regulator
ET445_06415	COG0640	Transcriptional regulator
ET445_06435	COG0738	Major facilitator superfamily
ET445_06450	COG1309	transcriptional regulator
ET445_06460	COG0514	ATP-dependent DNA helicase (RecQ)
ET445_06485	COG0039	L-malate dehydrogenase activity
ET445_06505	COG0697	spore germination
ET445_06535	COG1278	Cold shock
ET445_06555	COG0277	FAD linked oxidase domain protein
ET445_06585	COG3619	membrane
ET445_06640	COG4974	Belongs to the 'phage' integrase family
ET445_06660	COG0741	lytic transglycosylase activity
ET445_06660	COG0739	heme binding
ET445_06660	COG1196	nuclear chromosome segregation
ET445_06665	COG0791	NLP P60 protein
ET445_06665	COG3883	PFAM NLP P60 protein
ET445_06670	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
ET445_06675	COG0037	tRNA processing
ET445_06685	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ET445_06690	COG0302	gtp cyclohydrolase
ET445_06695	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
ET445_06700	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
ET445_06730	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
ET445_06735	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
ET445_06740	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ET445_06755	COG3655	Transcriptional regulator
ET445_06775	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
ET445_06790	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
ET445_06805	COG1472	Belongs to the glycosyl hydrolase 3 family
ET445_06890	COG0513	Belongs to the DEAD box helicase family
ET445_06930	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
ET445_06955	COG0085	RNA polymerase activity
ET445_06960	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
ET445_06965	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ET445_07000	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
ET445_07115	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
ET445_07120	COG0049	tRNA binding
ET445_07125	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
ET445_07130	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
ET445_07140	COG0051	transcription antitermination factor activity, RNA binding
ET445_07145	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
ET445_07150	COG0088	Forms part of the polypeptide exit tunnel
ET445_07155	COG0089	rRNA binding
ET445_07160	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
ET445_07165	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
ET445_07170	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
ET445_07175	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
ET445_07180	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
ET445_07185	COG0255	Belongs to the universal ribosomal protein uL29 family
ET445_07190	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
ET445_07195	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
ET445_07200	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
ET445_07205	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
ET445_07210	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
ET445_07215	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
ET445_07220	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
ET445_07225	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
ET445_07230	COG1841	ribosomal large subunit assembly
ET445_07240	COG0200	Binds to the 23S rRNA
ET445_07250	COG0563	adenylate kinase activity
ET445_07255	COG0024	Methionine aminopeptidase
ET445_07260	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ET445_07270	COG2213	PTS system mannitol-specific
ET445_07275	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
ET445_07290	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
ET445_07300	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
ET445_07305	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
ET445_07310	COG0202	RNA polymerase activity
ET445_07315	COG0203	ribosomal protein L17
ET445_07325	COG0101	tRNA pseudouridine synthase activity
ET445_07330	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
ET445_07335	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
ET445_07340	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ET445_07345	COG1072	(Pantothenic acid kinase))
ET445_07350	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
ET445_07355	COG0736	holo-[acyl-carrier-protein] synthase activity
ET445_07360	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
ET445_07365	COG0802	atpase or kinase
ET445_07380	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
ET445_07400	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
ET445_07450	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
ET445_07460	COG0516	GMP reductase activity
ET445_07480	COG0519	Catalyzes the synthesis of GMP from XMP
ET445_07480	COG0518	GMP synthase (glutamine-hydrolyzing) activity
ET445_07490	COG3795	YCII-related domain
ET445_07495	COG4941	Belongs to the sigma-70 factor family
ET445_07505	COG0584	glycerophosphoryl diester phosphodiesterase
ET445_07540	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
ET445_07545	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
ET445_07550	COG3639	organic phosphonate transmembrane transporter activity
ET445_07570	COG0045	succinate-CoA ligase (ADP-forming) activity
ET445_07620	COG0138	bifunctional purine biosynthesis protein purh
ET445_07625	COG1834	amidinotransferase
ET445_07630	COG1136	(ABC) transporter
ET445_07635	COG0577	efflux transmembrane transporter activity
ET445_07635	COG1136	(ABC) transporter
ET445_07655	COG1132	(ABC) transporter
ET445_07660	COG0019	diaminopimelate decarboxylase activity
ET445_07670	COG2197	response regulator
ET445_07675	COG4585	Histidine kinase
ET445_07690	COG0538	isocitrate dehydrogenase activity
ET445_07705	COG1175	transmembrane transport
ET445_07710	COG0395	ABC-type sugar transport system, permease component
ET445_07715	COG1472	Belongs to the glycosyl hydrolase 3 family
ET445_07720	COG1940	carbohydrate kinase activity
ET445_07765	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
ET445_07770	COG1349	DNA-binding transcription factor activity
ET445_07775	COG0191	fructose-bisphosphate aldolase activity
ET445_07790	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
ET445_07805	COG0395	ABC-type sugar transport system, permease component
ET445_07820	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
ET445_07825	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
ET445_07845	COG1083	cytidylyl-transferase
ET445_07850	COG2089	acid synthase
ET445_07870	COG0442	prolyl-tRNA aminoacylation
ET445_07880	COG2017	converts alpha-aldose to the beta-anomer
ET445_07950	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
ET445_07975	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
ET445_07980	COG0745	RESPONSE REGULATOR receiver
ET445_07990	COG3485	protocatechuate 3,4-dioxygenase
ET445_08005	COG0588	phosphoglycerate mutase activity
ET445_08020	COG0745	RESPONSE REGULATOR receiver
ET445_08035	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
ET445_08035	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
ET445_08040	COG0215	cysteine-tRNA ligase activity
ET445_08055	COG3842	ATPase activity
ET445_08080	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ET445_08095	COG1278	Cold shock
ET445_08100	COG1470	cell adhesion involved in biofilm formation
ET445_08115	COG5000	phosphorelay sensor kinase activity
ET445_08115	COG5002	protein histidine kinase activity
ET445_08120	COG0745	RESPONSE REGULATOR receiver
ET445_08130	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
ET445_08140	COG1061	Type III restriction enzyme res subunit
ET445_08155	COG1278	Cold shock
ET445_08170	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
ET445_08175	COG1321	iron dependent repressor
ET445_08180	COG0791	NLP P60 protein
ET445_08190	COG1388	LysM domain
ET445_08190	COG3942	CHAP domain
ET445_08215	COG3415	Transposase
ET445_08215	COG2801	Transposase and inactivated derivatives
ET445_08290	COG1793	dna ligase
ET445_08295	COG1522	sequence-specific DNA binding
ET445_08300	COG0686	Belongs to the AlaDH PNT family
ET445_08335	COG1210	Utp--glucose-1-phosphate uridylyltransferase
ET445_08365	COG2814	Major facilitator Superfamily
ET445_08370	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ET445_08390	COG0490	domain, Protein
ET445_08390	COG2985	domain, Protein
ET445_08410	COG0656	L-ascorbic acid biosynthetic process
ET445_08420	COG0640	Transcriptional regulator
ET445_08430	COG1643	Atp-dependent helicase
ET445_08455	COG1331	Highly conserved protein containing a thioredoxin domain
ET445_08475	COG0484	heat shock protein binding
ET445_08480	COG1362	aminopeptidase activity
ET445_08490	COG2897	thiosulfate sulfurtransferase activity
ET445_08515	COG1832	CoA-binding protein
ET445_08535	COG1335	isochorismatase
ET445_08575	COG2076	Multidrug Resistance protein
ET445_08585	COG1476	TRANSCRIPTIONal
ET445_08600	COG1928	C-terminal four TMM region of protein-O-mannosyltransferase
ET445_08620	COG0084	hydrolase, TatD family'
ET445_08625	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
ET445_08635	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
ET445_08640	COG0488	(ABC) transporter
ET445_08645	COG2813	Specifically methylates the guanine in position
ET445_08655	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
ET445_08660	COG2011	ABC-type metal ion transport system permease component
ET445_08670	COG1403	HNH endonuclease
ET445_08690	COG4221	oxidoreductase activity
ET445_08705	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
ET445_08715	COG0318	PFAM AMP-dependent synthetase and ligase
ET445_08735	COG2149	membrane
ET445_08740	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
ET445_08760	COG0395	ABC-type sugar transport system, permease component
ET445_08765	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
ET445_08765	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
ET445_08775	COG1349	DNA-binding transcription factor activity
ET445_08780	COG0473	3-isopropylmalate dehydrogenase activity
ET445_08785	COG1012	belongs to the aldehyde dehydrogenase family
ET445_08790	COG1028	Short-chain dehydrogenase reductase Sdr
ET445_08830	COG1028	Short-chain dehydrogenase reductase Sdr
ET445_08840	COG0477	Major facilitator Superfamily
ET445_08900	COG0673	inositol 2-dehydrogenase activity
ET445_08905	COG1028	Short-chain dehydrogenase reductase Sdr
ET445_08915	COG3386	PFAM SMP-30 Gluconolaconase
ET445_08940	COG4948	Mandelate Racemase Muconate Lactonizing
ET445_08950	COG1904	glucuronate isomerase
ET445_08965	COG0673	inositol 2-dehydrogenase activity
ET445_08975	COG0246	Mannitol dehydrogenase
ET445_08980	COG4948	Mandelate Racemase Muconate Lactonizing
ET445_08985	COG3265	gluconokinase activity
ET445_08990	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
ET445_09015	COG0193	aminoacyl-tRNA hydrolase activity
ET445_09045	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
ET445_09060	COG0124	histidyl-tRNA synthetase
ET445_09075	COG0148	phosphopyruvate hydratase activity
ET445_09090	COG1404	Belongs to the peptidase S8 family
ET445_09105	COG2140	Oxalate decarboxylase
ET445_09110	COG0248	Ppx GppA phosphatase
ET445_09150	COG1704	LemA family
ET445_09160	COG3214	Protein conserved in bacteria
ET445_09170	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
ET445_09175	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ET445_09195	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
ET445_09205	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
ET445_09210	COG0114	fumarate hydratase activity
ET445_09225	COG1722	exodeoxyribonuclease VII activity
ET445_09230	COG1570	exodeoxyribonuclease VII activity
ET445_09235	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
ET445_09260	COG0191	fructose-bisphosphate aldolase activity
ET445_09265	COG1494	fructose-1,6-bisphosphatase
ET445_09280	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ET445_09285	COG4166	transmembrane transport
ET445_09295	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ET445_09310	COG1619	proteins homologs of microcin C7 resistance protein MccF
ET445_09315	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ET445_09330	COG4948	Mandelate Racemase Muconate Lactonizing
ET445_09335	COG1322	Protein conserved in bacteria
ET445_09340	COG2176	DNA-directed DNA polymerase activity
ET445_09360	COG0012	GTP binding
ET445_09370	COG2824	Alkylphosphonate utilization operon protein PhnA
ET445_09415	COG0488	(ABC) transporter
ET445_09465	COG1846	Transcriptional regulator
ET445_09470	COG0697	spore germination
ET445_09475	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
ET445_09535	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
ET445_09540	COG2890	protein-(glutamine-N5) methyltransferase activity
ET445_09560	COG2814	Major facilitator Superfamily
ET445_09565	COG1104	cysteine desulfurase activity
ET445_09575	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
ET445_09580	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
ET445_09605	COG0404	The glycine cleavage system catalyzes the degradation of glycine
ET445_09610	COG0509	glycine decarboxylation via glycine cleavage system
ET445_09615	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
ET445_09615	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
ET445_09635	COG4166	transmembrane transport
ET445_09640	COG0601	transmembrane transport
ET445_09660	COG0739	heme binding
ET445_09660	COG1196	nuclear chromosome segregation
ET445_09660	COG0741	lytic transglycosylase activity
ET445_09700	COG2171	N-acyltransferase activity
ET445_09705	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ET445_09725	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ET445_09760	COG2239	Acts as a magnesium transporter
ET445_09770	COG0006	proline dipeptidase activity
ET445_09780	COG0613	PHP domain protein
ET445_09785	COG0513	Belongs to the DEAD box helicase family
ET445_09810	COG0210	DNA helicase
ET445_09835	COG3480	Lon protease (S16) C-terminal proteolytic domain
ET445_09840	COG1615	UPF0182 protein
ET445_09900	COG0488	(ABC) transporter
ET445_09905	COG1028	Short-chain dehydrogenase reductase Sdr
ET445_09915	COG0596	Alpha beta hydrolase
ET445_09925	COG0028	Belongs to the TPP enzyme family
ET445_09935	COG1028	Short-chain dehydrogenase reductase Sdr
ET445_09955	COG0598	Magnesium transport protein CorA
ET445_09960	COG0588	phosphoglycerate mutase activity
ET445_09965	COG0596	Alpha beta hydrolase
ET445_09970	COG3973	AAA domain
ET445_09980	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ET445_09990	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ET445_10015	COG2337	Toxic component of a toxin-antitoxin (TA) module
ET445_10030	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
ET445_10115	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
ET445_10120	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
ET445_10125	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
ET445_10135	COG0586	Pfam SNARE associated Golgi protein
ET445_10150	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
ET445_10165	COG0490	domain, Protein
ET445_10165	COG0471	metal ion transport
ET445_10225	COG1733	regulation of RNA biosynthetic process
ET445_10235	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
ET445_10240	COG2884	Cell division ATP-binding protein ftsE
ET445_10250	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
ET445_10270	COG2271	Major facilitator Superfamily
ET445_10290	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ET445_10295	COG1120	ATPase activity
ET445_10300	COG0025	NhaP-type Na H and K H
ET445_10305	COG0483	inositol monophosphate 1-phosphatase activity
ET445_10340	COG2197	response regulator
ET445_10350	COG3634	alkyl hydroperoxide reductase activity
ET445_10360	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
ET445_10365	COG1122	ATPase activity
ET445_10370	COG1268	BioY protein
ET445_10390	COG2409	Drug exporters of the RND superfamily
ET445_10395	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
ET445_10400	COG0129	dihydroxy-acid dehydratase activity
ET445_10405	COG0028	Belongs to the TPP enzyme family
ET445_10410	COG0440	acetolactate synthase activity
ET445_10415	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
ET445_10420	COG4085	toxin activity
ET445_10420	COG0737	Belongs to the 5'-nucleotidase family
ET445_10420	COG1525	nuclease
ET445_10430	COG3629	intracellular signal transduction
ET445_10435	COG3142	Participates in the control of copper homeostasis
ET445_10465	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ET445_10470	COG0456	acetyltransferase
ET445_10475	COG0179	Fumarylacetoacetate (FAA) hydrolase
ET445_10485	COG3844	kynureninase activity
ET445_10490	COG0583	DNA-binding transcription factor activity
ET445_10495	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ET445_10520	COG3550	peptidyl-serine autophosphorylation
ET445_10545	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
ET445_10545	COG1199	ATP-dependent helicase activity
ET445_10555	COG3415	Transposase
ET445_10555	COG2801	Transposase and inactivated derivatives
ET445_10585	COG0745	RESPONSE REGULATOR receiver
ET445_10590	COG2205	protein histidine kinase activity
ET445_10600	COG0596	Alpha beta hydrolase
ET445_10635	COG2188	Transcriptional regulator
ET445_10650	COG1129	ABC transporter
ET445_10655	COG1172	Belongs to the binding-protein-dependent transport system permease family
ET445_10660	COG1070	Carbohydrate kinase
ET445_10665	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ET445_10670	COG0800	Aldolase
ET445_10680	COG1735	metal-dependent hydrolase with the TIM-barrel fold
ET445_10715	COG0492	ferredoxin-NADP+ reductase activity
ET445_10745	COG2910	NAD(P)H-binding
ET445_10760	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ET445_10790	COG0631	protein serine/threonine phosphatase activity
ET445_10820	COG0714	Associated with various cellular activities
ET445_10840	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
ET445_10845	COG0066	3-isopropylmalate dehydratase activity
ET445_10850	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
ET445_10855	COG0204	Acyl-transferase
ET445_10855	COG0318	PFAM AMP-dependent synthetase and ligase
ET445_10860	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
ET445_10865	COG1181	Belongs to the D-alanine--D-alanine ligase family
ET445_10880	COG0742	ribosomal rna small subunit methyltransferase
ET445_10890	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
ET445_10895	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
ET445_10900	COG0714	Associated with various cellular activities
ET445_10920	COG0333	Belongs to the bacterial ribosomal protein bL32 family
ET445_10925	COG0571	ribonuclease III activity
ET445_10930	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
ET445_10940	COG1196	nuclear chromosome segregation
ET445_10955	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
ET445_10980	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
ET445_10985	COG0228	four-way junction DNA binding
ET445_10990	COG1837	Belongs to the UPF0109 family
ET445_10995	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
ET445_11000	COG0336	Belongs to the RNA methyltransferase TrmD family
ET445_11020	COG0335	large ribosomal subunit rRNA binding
ET445_11025	COG0681	Belongs to the peptidase S26 family
ET445_11030	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
ET445_11040	COG0792	nuclease activity
ET445_11060	COG4974	Belongs to the 'phage' integrase family
ET445_11070	COG0052	Belongs to the universal ribosomal protein uS2 family
ET445_11075	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
ET445_11085	COG0233	cytoplasmic translational termination
ET445_11130	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
ET445_11135	COG0366	Alpha amylase catalytic
ET445_11140	COG0058	SHG alpha-glucan phosphorylase activity
ET445_11150	COG1523	belongs to the glycosyl hydrolase 13 family
ET445_11160	COG0482	sulfurtransferase activity
ET445_11165	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
ET445_11175	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
ET445_11180	COG0154	amidase activity
ET445_11185	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
ET445_11195	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
ET445_11205	COG4721	ABC-type cobalt transport system, permease component
ET445_11220	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
ET445_11245	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
ET445_11255	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
ET445_11270	COG0667	Aldo Keto reductase
ET445_11275	COG0629	single-stranded DNA binding
ET445_11305	COG1946	Acyl-CoA thioesterase
ET445_11325	COG0668	transmembrane transport
ET445_11335	COG2197	response regulator
ET445_11360	COG3177	Filamentation induced by cAMP protein fic
ET445_11385	COG1574	metal-dependent hydrolase with the TIM-barrel fold
ET445_11395	COG2197	response regulator
ET445_11400	COG0783	Belongs to the Dps family
ET445_11405	COG2197	response regulator
ET445_11415	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ET445_11425	COG2376	Dihydroxyacetone kinase
ET445_11445	COG0544	peptidyl-prolyl cis-trans isomerase activity
ET445_11455	COG0740	serine-type endopeptidase activity
ET445_11460	COG0740	serine-type endopeptidase activity
ET445_11465	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
ET445_11495	COG0756	dUTP diphosphatase activity
ET445_11515	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
ET445_11530	COG1024	Enoyl-CoA hydratase
ET445_11530	COG1250	3-hydroxyacyl-CoA dehydrogenase
ET445_11535	COG0183	Belongs to the thiolase family
ET445_11540	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
ET445_11580	COG0569	domain protein
ET445_11580	COG2985	domain, Protein
ET445_11605	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
ET445_11625	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
ET445_11630	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
ET445_11645	COG0217	transcriptional regulatory protein
ET445_11650	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
ET445_11655	COG0632	four-way junction helicase activity
ET445_11660	COG2255	four-way junction helicase activity
ET445_11670	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ET445_11675	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ET445_11680	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ET445_11715	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
ET445_11720	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
ET445_11730	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
ET445_11735	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
ET445_11745	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
ET445_11750	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
ET445_11755	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
ET445_11760	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ET445_11775	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
ET445_11780	COG0540	Belongs to the ATCase OTCase family
ET445_11785	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
ET445_11795	COG0505	Belongs to the CarA family
ET445_11805	COG0284	orotidine-5'-phosphate decarboxylase activity
ET445_11810	COG0194	GDP metabolic process
ET445_11815	COG1758	RNA polymerase activity
ET445_11825	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
ET445_11835	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
ET445_11845	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
ET445_11850	COG0140	phosphoribosyl-ATP diphosphatase activity
ET445_11855	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
ET445_11860	COG0107	imidazoleglycerol-phosphate synthase activity
ET445_11865	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
ET445_11880	COG0134	indole-3-glycerol-phosphate synthase activity
ET445_11885	COG0133	tryptophan synthase activity
ET445_11890	COG0159	tryptophan synthase activity
ET445_11895	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
ET445_11900	COG0067	glutamate synthase
ET445_11900	COG0069	glutamate synthase activity
ET445_11900	COG0070	glutamate synthase
ET445_11935	COG0539	negative regulation of cytoplasmic translation
ET445_11945	COG0237	dephospho-CoA kinase activity
ET445_11950	COG0556	nucleotide-excision repair
ET445_11960	COG0322	excinuclease ABC activity
ET445_11965	COG1660	Displays ATPase and GTPase activities
ET445_11970	COG1481	regulation of sporulation
ET445_11985	COG0126	phosphoglycerate kinase activity
ET445_11990	COG0149	triose-phosphate isomerase activity
ET445_11995	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
ET445_12005	COG0363	glucosamine-6-phosphate deaminase activity
ET445_12020	COG0166	Belongs to the GPI family
ET445_12025	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
ET445_12035	COG0109	protoheme IX farnesyltransferase activity
ET445_12050	COG0719	Fe-S assembly protein
ET445_12060	COG0396	ATPase activity
ET445_12065	COG2151	metal-sulfur cluster biosynthetic enzyme
ET445_12085	COG0525	valine-tRNA ligase activity
ET445_12105	COG0747	negative chemotaxis
ET445_12125	COG0285	dihydrofolate synthase activity
ET445_12145	COG1530	ribonuclease E activity
ET445_12155	COG0261	This protein binds to 23S rRNA in the presence of protein L20
ET445_12160	COG0211	Belongs to the bacterial ribosomal protein bL27 family
ET445_12165	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
ET445_12170	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
ET445_12175	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
ET445_12185	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
ET445_12190	COG0799	negative regulation of ribosome biogenesis
ET445_12200	COG2801	Transposase and inactivated derivatives
ET445_12200	COG3415	Transposase
ET445_12225	COG0022	dehydrogenase e1 component
ET445_12275	COG0488	(ABC) transporter
ET445_12300	COG0589	response to stress
ET445_12305	COG0560	Phosphoserine phosphatase
ET445_12305	COG3830	Belongs to the UPF0237 family
ET445_12315	COG0297	glycogen (starch) synthase activity
ET445_12320	COG1119	ATPase activity
ET445_12325	COG0254	rRNA binding
ET445_12335	COG2267	carboxylic ester hydrolase activity
ET445_12345	COG0406	alpha-ribazole phosphatase activity
ET445_12400	COG0531	amino acid
ET445_12425	COG0596	Alpha beta hydrolase
ET445_12430	COG0587	DNA-directed DNA polymerase activity
ET445_12450	COG0463	Glycosyl transferase, family 2
ET445_12465	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ET445_12470	COG1968	undecaprenyl-diphosphatase activity
ET445_12505	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ET445_12510	COG0805	protein transport
ET445_12530	COG0584	glycerophosphoryl diester phosphodiesterase
ET445_12545	COG1028	Short-chain dehydrogenase reductase Sdr
ET445_12575	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
ET445_12635	COG1028	Short-chain dehydrogenase reductase Sdr
ET445_12645	COG1461	Dihydroxyacetone kinase
ET445_12650	COG2376	Dihydroxyacetone kinase
ET445_12655	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
ET445_12660	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
ET445_12665	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
ET445_12670	COG1845	cytochrome c oxidase, subunit III
ET445_12675	COG2010	Cytochrome c
ET445_12680	COG0723	plastoquinol--plastocyanin reductase activity
ET445_12685	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
ET445_12690	COG2226	methyltransferase
ET445_12700	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
ET445_12705	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
ET445_12715	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ET445_12735	COG0187	DNA topoisomerase II activity
ET445_12755	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
ET445_12765	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
ET445_12770	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ET445_12775	COG0508	dehydrogenase complex catalyzes the overall conversion of
ET445_12785	COG0321	lipoyl(octanoyl) transferase activity
ET445_12790	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
ET445_12805	COG0174	glutamine synthetase
ET445_12810	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
ET445_12820	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
ET445_12845	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
ET445_12885	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
ET445_12900	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ET445_12905	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ET445_12910	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ET445_12950	COG3639	organic phosphonate transmembrane transporter activity
ET445_12980	COG0242	peptide deformylase activity
ET445_12995	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
ET445_13025	COG0601	transmembrane transport
ET445_13035	COG0358	DNA primase activity
ET445_13040	COG0232	Belongs to the dGTPase family. Type 2 subfamily
ET445_13055	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
ET445_13065	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
ET445_13075	COG2860	membrane
ET445_13090	COG1879	ABC-type sugar transport system periplasmic component
ET445_13095	COG1129	ABC transporter
ET445_13100	COG1172	Belongs to the binding-protein-dependent transport system permease family
ET445_13110	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ET445_13115	COG0577	efflux transmembrane transporter activity
ET445_13120	COG1136	(ABC) transporter
ET445_13125	COG2197	response regulator
ET445_13130	COG4585	Histidine kinase
ET445_13135	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
ET445_13145	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
ET445_13155	COG0537	adenosine 5'-monophosphoramidase activity
ET445_13165	COG0484	heat shock protein binding
ET445_13170	COG1420	regulation of RNA biosynthetic process
ET445_13210	COG4762	Protein conserved in bacteria
ET445_13225	COG0268	Binds directly to 16S ribosomal RNA
ET445_13255	COG0495	leucyl-tRNA aminoacylation
ET445_13260	COG0512	Glutamine amidotransferase of anthranilate synthase
ET445_13260	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
ET445_13265	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
ET445_13275	COG1294	oxidase, subunit
ET445_13280	COG1271	oxidase subunit
ET445_13295	COG0586	Pfam SNARE associated Golgi protein
ET445_13300	COG1732	Glycine betaine
ET445_13305	COG1174	glycine betaine transport
ET445_13310	COG1174	glycine betaine transport
ET445_13330	COG0167	dihydroorotate dehydrogenase activity
ET445_13335	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
ET445_13340	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
ET445_13345	COG0587	DNA-directed DNA polymerase activity
ET445_13370	COG1799	cell septum assembly
ET445_13380	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
ET445_13395	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
ET445_13405	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
ET445_13410	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ET445_13420	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
ET445_13425	COG0768	penicillin binding
ET445_13435	COG0275	rRNA processing
ET445_13460	COG3942	CHAP domain
ET445_13460	COG1388	LysM domain
ET445_13470	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
ET445_13480	COG1940	carbohydrate kinase activity
ET445_13520	COG1716	ATPase activity
ET445_13550	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
ET445_13560	COG3012	SEC-C Motif Domain Protein
ET445_13655	COG2909	trisaccharide binding
ET445_13685	COG1063	alcohol dehydrogenase
ET445_13695	COG0438	transferase activity, transferring glycosyl groups
ET445_13705	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ET445_13705	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ET445_13725	COG2226	methyltransferase
ET445_13785	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
ET445_13835	COG0300	oxidoreductase activity
ET445_13850	COG1309	transcriptional regulator
ET445_13960	COG1872	DUF167
ET445_13965	COG0477	Major facilitator Superfamily
ET445_13970	COG1160	GTP binding
ET445_13975	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
ET445_13990	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
ET445_14010	COG0494	nUDIX hydrolase
ET445_14015	COG0504	CTP synthase activity
ET445_14020	COG0497	DNA recombination
ET445_14025	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
ET445_14040	COG0647	UMP catabolic process
ET445_14060	COG1804	L-carnitine dehydratase bile acid-inducible protein F
ET445_14065	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
ET445_14080	COG2094	Belongs to the DNA glycosylase MPG family
ET445_14085	COG0165	Argininosuccinate lyase
ET445_14090	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
ET445_14105	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
ET445_14110	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
ET445_14120	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ET445_14120	COG0072	phenylalanine-tRNA ligase activity
ET445_14125	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
ET445_14130	COG0765	amino acid transport
ET445_14135	COG0765	amino acid transport
ET445_14145	COG1126	abc transporter atp-binding protein
ET445_14150	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ET445_14155	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
ET445_14160	COG0291	Belongs to the bacterial ribosomal protein bL35 family
ET445_14165	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
ET445_14175	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
ET445_14195	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
ET445_14200	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
ET445_14205	COG0131	Imidazoleglycerol-phosphate dehydratase
ET445_14220	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
ET445_14225	COG2267	carboxylic ester hydrolase activity
ET445_14230	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
ET445_14240	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
ET445_14245	COG2813	Specifically methylates the guanine in position
ET445_14250	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
ET445_14255	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
ET445_14260	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ET445_14270	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
ET445_14285	COG1058	Belongs to the CinA family
ET445_14285	COG1546	Belongs to the CinA family
ET445_14295	COG1674	ftsk spoiiie
ET445_14300	COG0456	acetyltransferase
ET445_14305	COG0577	efflux transmembrane transporter activity
ET445_14310	COG0577	efflux transmembrane transporter activity
ET445_14310	COG1136	(ABC) transporter
ET445_14325	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
ET445_14330	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ET445_14345	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
ET445_14365	COG1090	epimerase
ET445_14375	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
ET445_14390	COG0612	Peptidase, M16
ET445_14395	COG0667	Aldo Keto reductase
ET445_14410	COG1960	acyl-CoA dehydrogenase activity
ET445_14420	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
ET445_14435	COG1309	transcriptional regulator
ET445_14440	COG2154	pterin-4-alpha-carbinolamine dehydratase
ET445_14445	COG0508	dehydrogenase complex catalyzes the overall conversion of
ET445_14450	COG0022	dehydrogenase e1 component
ET445_14465	COG0300	oxidoreductase activity
ET445_14470	COG2755	lipolytic protein G-D-S-L family
ET445_14475	COG1185	polyribonucleotide nucleotidyltransferase activity
ET445_14500	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ET445_14525	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ET445_14545	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
ET445_14555	COG2072	flavoprotein involved in K transport
ET445_14570	COG3189	MarR family transcriptional regulator
ET445_14575	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
ET445_14600	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
ET445_14615	COG0545	Peptidyl-prolyl cis-trans isomerase
ET445_14625	COG0277	FAD linked oxidase domain protein
ET445_14635	COG2186	Transcriptional regulator
ET445_14670	COG4948	Mandelate Racemase Muconate Lactonizing
ET445_14675	COG0179	Fumarylacetoacetate (FAA) hydrolase
ET445_14680	COG1028	Short-chain dehydrogenase reductase Sdr
ET445_14700	COG2233	PERMEase
ET445_14705	COG2252	PERMEase
ET445_14730	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
ET445_14755	COG1937	Protein conserved in bacteria
ET445_14770	COG1012	belongs to the aldehyde dehydrogenase family
ET445_14775	COG1012	belongs to the aldehyde dehydrogenase family
ET445_14780	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
ET445_14785	COG2390	Transcriptional regulator
ET445_14800	COG2807	transmembrane transport
ET445_14805	COG0196	riboflavin kinase activity
ET445_14820	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
ET445_14825	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
ET445_14855	COG1028	Short-chain dehydrogenase reductase Sdr
ET445_14860	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
ET445_14865	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
ET445_14875	COG0195	Participates in both transcription termination and antitermination
ET445_14880	COG1611	Belongs to the LOG family
ET445_14885	COG0442	prolyl-tRNA aminoacylation
ET445_14900	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
ET445_14905	COG2267	carboxylic ester hydrolase activity
ET445_14925	COG1028	Short-chain dehydrogenase reductase Sdr
ET445_14930	COG1309	transcriptional regulator
ET445_14935	COG0318	PFAM AMP-dependent synthetase and ligase
ET445_14960	COG0183	Belongs to the thiolase family
ET445_14975	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
ET445_14975	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
ET445_14995	COG1253	flavin adenine dinucleotide binding
ET445_15000	COG2197	response regulator
ET445_15005	COG4585	Histidine kinase
ET445_15010	COG0750	zinc metalloprotease
ET445_15015	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
ET445_15050	COG1177	transmembrane transport
ET445_15055	COG1176	ABC-type spermidine putrescine transport system, permease component I
ET445_15060	COG3842	ATPase activity
ET445_15105	COG0631	protein serine/threonine phosphatase activity
ET445_15120	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
ET445_15125	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ET445_15135	COG0667	Aldo Keto reductase
ET445_15140	COG2818	Glycosylase
ET445_15155	COG0355	proton-transporting ATP synthase activity, rotational mechanism
ET445_15160	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
ET445_15165	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
ET445_15170	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
ET445_15175	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
ET445_15180	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
ET445_15185	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
ET445_15190	COG0356	it plays a direct role in the translocation of protons across the membrane
ET445_15200	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ET445_15230	COG2890	protein-(glutamine-N5) methyltransferase activity
ET445_15240	COG1045	serine acetyltransferase
ET445_15250	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
ET445_15260	COG0083	homoserine kinase activity
ET445_15265	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
ET445_15270	COG0460	homoserine dehydrogenase
ET445_15275	COG0019	diaminopimelate decarboxylase activity
ET445_15290	COG1940	carbohydrate kinase activity
ET445_15305	COG1595	DNA-templated transcription, initiation
ET445_15320	COG1842	Phage shock protein A
ET445_15325	COG0010	Belongs to the arginase family
ET445_15330	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ET445_15355	COG1120	ATPase activity
ET445_15360	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ET445_15365	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ET445_15375	COG0154	amidase activity
ET445_15385	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
ET445_15395	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
ET445_15415	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
ET445_15465	COG0765	amino acid transport
ET445_15480	COG1011	Hydrolase
ET445_15485	COG1902	pentaerythritol trinitrate reductase activity
ET445_15515	COG1136	(ABC) transporter
ET445_15525	COG0567	Dehydrogenase, E1 component
ET445_15525	COG0508	dehydrogenase complex catalyzes the overall conversion of
ET445_15535	COG1595	DNA-templated transcription, initiation
ET445_15540	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
ET445_15545	COG1162	GTPase activity
ET445_15595	COG0653	protein targeting
ET445_15600	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
ET445_15605	COG1040	competence protein
ET445_15610	COG5401	PFAM Sporulation and spore germination
ET445_15615	COG5002	protein histidine kinase activity
ET445_15640	COG0714	Associated with various cellular activities
ET445_15650	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
ET445_15665	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
ET445_15680	COG1063	alcohol dehydrogenase
ET445_15685	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ET445_15715	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
ET445_15720	COG4977	sequence-specific DNA binding
ET445_15725	COG1482	cell wall glycoprotein biosynthetic process
ET445_15730	COG1960	acyl-CoA dehydrogenase activity
ET445_15755	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ET445_15765	COG0673	inositol 2-dehydrogenase activity
ET445_15770	COG1216	Glycosyl transferase, family 2
ET445_15780	COG1215	transferase activity, transferring glycosyl groups
ET445_15835	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ET445_15855	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ET445_15865	COG1216	Glycosyl transferase, family 2
ET445_15865	COG0438	transferase activity, transferring glycosyl groups
ET445_15885	COG1088	dTDP-glucose 4,6-dehydratase activity
ET445_15900	COG1316	TRANSCRIPTIONal
ET445_15940	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
ET445_15965	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
ET445_15970	COG0424	maF-like protein
ET445_15975	COG4770	biotin carboxylase activity
ET445_15995	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ET445_16000	COG0531	amino acid
ET445_16015	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ET445_16030	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
ET445_16060	COG1744	ABC transporter substrate-binding protein PnrA-like
ET445_16075	COG2009	succinate dehydrogenase
ET445_16090	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
ET445_16110	COG0708	Exodeoxyribonuclease III
ET445_16115	COG0180	Tryptophanyl-tRNA synthetase
ET445_16120	COG1011	Hydrolase
ET445_16130	COG2390	Transcriptional regulator
ET445_16135	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
ET445_16140	COG1695	Transcriptional regulator
ET445_16155	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ET445_16155	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ET445_16160	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
ET445_16170	COG0477	Major facilitator Superfamily
ET445_16195	COG1132	(ABC) transporter
ET445_16215	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
ET445_16240	COG0183	Belongs to the thiolase family
ET445_16265	COG3971	2-oxopent-4-enoate hydratase activity
ET445_16275	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
ET445_16285	COG1012	belongs to the aldehyde dehydrogenase family
ET445_16305	COG1335	isochorismatase
ET445_16365	COG1754	DNA topoisomerase type I activity
ET445_16365	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
ET445_16410	COG0110	maltose O-acetyltransferase activity
ET445_16415	COG0438	transferase activity, transferring glycosyl groups
ET445_16430	COG2244	polysaccharide biosynthetic process
ET445_16460	COG1215	transferase activity, transferring glycosyl groups
ET445_16465	COG0318	PFAM AMP-dependent synthetase and ligase
ET445_16470	COG0318	PFAM AMP-dependent synthetase and ligase
ET445_16475	COG0318	PFAM AMP-dependent synthetase and ligase
ET445_16485	COG2091	lysine biosynthetic process via aminoadipic acid
ET445_16500	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
ET445_16505	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ET445_16525	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ET445_16540	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
ET445_16630	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
ET445_16635	COG0489	protein tyrosine kinase activity
ET445_16670	COG0488	(ABC) transporter
ET445_16675	COG0579	oxidoreductase
ET445_16685	COG1486	melibiose metabolic process
ET445_16690	COG1940	carbohydrate kinase activity
ET445_16690	COG1846	Transcriptional regulator
ET445_16695	COG4608	Belongs to the ABC transporter superfamily
ET445_16700	COG0444	Belongs to the ABC transporter superfamily
ET445_16710	COG0601	transmembrane transport
ET445_16725	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
ET445_16730	COG1414	Transcriptional regulator
ET445_16765	COG5002	protein histidine kinase activity
ET445_16790	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
ET445_16815	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
ET445_16830	COG0385	Bile acid
ET445_16850	COG3415	Transposase
ET445_16850	COG2801	Transposase and inactivated derivatives
ET445_16865	COG0456	acetyltransferase
ET445_16870	COG0433	COG0433 Predicted ATPase
ET445_16905	COG0315	cyclic pyranopterin monophosphate synthase activity
ET445_16915	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
ET445_16920	COG0314	molybdopterin synthase activity
ET445_16925	COG0315	cyclic pyranopterin monophosphate synthase activity
ET445_16925	COG0521	Mo-molybdopterin cofactor biosynthetic process
ET445_16940	COG4948	Mandelate Racemase Muconate Lactonizing
ET445_16960	COG0277	FAD linked oxidase domain protein
ET445_16970	COG2814	Major facilitator Superfamily
ET445_16985	COG1175	transmembrane transport
ET445_16990	COG0395	ABC-type sugar transport system, permease component
ET445_17005	COG2115	Belongs to the xylose isomerase family
ET445_17010	COG1070	Carbohydrate kinase
ET445_17015	COG3693	PFAM glycoside hydrolase, family 10