locus-tag	class	description
ET445_00010	ENOG4105BZW	Glycerate kinase
ET445_00020	ENOG4105HHS	UPF0256 protein
ET445_00030	ENOG4105C2J	ABC transporter
ET445_00035	ENOG4108HWW	ABC transporter
ET445_00055	ENOG4107T8T	UPF0173 metal-dependent hydrolase
ET445_00110	ENOG4105NDF	NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity)
ET445_00120	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
ET445_00125	ENOG4105CVJ	phosphoglycerate mutase
ET445_00135	ENOG41090KN	UPF0303 protein
ET445_00190	ENOG4108Z7F	N-acetyltransferase
ET445_00205	ENOG4107RYT	DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair (By similarity)
ET445_00225	ENOG4107S5I	aldo keto reductase
ET445_00230	ENOG4108JGH	Tetr family transcriptional regulator
ET445_00235	ENOG4108IXY	short-chain dehydrogenase reductase
ET445_00245	ENOG4107QM2	Aldo Keto reductase
ET445_00260	ENOG4105D5Q	Arginine ornithine antiporter
ET445_00270	ENOG4105E0A	ABC, transporter
ET445_00275	ENOG4105TVJ	transport system, permease
ET445_00280	ENOG4105DQ5	transport system permease protein
ET445_00305	ENOG4105BZ1	(ABC) transporter
ET445_00345	ENOG4105EZR	dyp-type peroxidase family protein
ET445_00405	ENOG4105D56	permease protein
ET445_00410	ENOG4105DRW	binding-protein-dependent transport systems inner membrane Component
ET445_00415	ENOG4105E0S	extracellular solute-binding protein family 1
ET445_00430	ENOG4105CNT	hydrolase family 2
ET445_00540	ENOG4107QRI	Phosphoketolase
ET445_00550	ENOG4105CIR	epoxide hydrolase
ET445_00555	ENOG4105WH1	Two component transcriptional regulator luxr family
ET445_00565	ENOG4105C5H	ABC transporter
ET445_00630	ENOG4105C9M	aspartyl-trna synthetase
ET445_00640	ENOG4107R50	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity)
ET445_00645	ENOG4105E0X	reductase
ET445_00655	ENOG4107T66	Releases the N-terminal proline from various substrates (By similarity)
ET445_00675	ENOG4105C57	major facilitator superfamily
ET445_00710	ENOG4105YVS	arsR family transcriptional regulator
ET445_00715	ENOG4108SY4	MarR family Transcriptional regulator
ET445_00765	ENOG4105M4H	endoribonuclease L-psp
ET445_00805	ENOG4105E05	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
ET445_00815	ENOG4105BZH	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
ET445_00820	ENOG4105G3E	Probably involved in ribonucleotide reductase function (By similarity)
ET445_00825	ENOG4105WAZ	(Glutaredoxin-like protein) NrdH
ET445_00840	ENOG4105DFW	ABC transporter
ET445_00845	ENOG41062B0	ABC transporter, permease
ET445_00855	ENOG4105ETE	Transcriptional regulator (LacI family
ET445_00875	ENOG4105DVH	amino acid
ET445_00900	ENOG4105D64	Mechanosensitive ion channel
ET445_00905	ENOG4105C8Q	Methyl-accepting chemotaxis
ET445_00910	ENOG4105BZ1	(ABC) transporter
ET445_00915	ENOG4105EB1	binding-protein-dependent transport systems inner membrane Component
ET445_00915	ENOG4105EB1	binding-protein-dependent transport systems inner membrane Component
ET445_00920	ENOG4105S9S	Binding-protein-dependent transport systems, inner membrane component
ET445_00925	ENOG4105EPJ	extracellular solute-binding protein family 1
ET445_00930	ENOG4105ETE	Transcriptional regulator (LacI family
ET445_00935	ENOG4105DXB	Major Facilitator superfamily
ET445_00940	ENOG4105XMC	MarR family Transcriptional regulator
ET445_00945	ENOG41082SK	Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity)
ET445_00950	ENOG4108VZM	50s ribosomal protein L10
ET445_00955	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
ET445_00970	ENOG4105BZU	Histidine kinase
ET445_00975	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
ET445_00985	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
ET445_01035	ENOG4108ZF3	Phosphatase
ET445_01055	ENOG4105C7R	Atpase associated with various cellular activities aaa_3
ET445_01125	ENOG4105RX7	peptidase S8 and S53, subtilisin, kexin, sedolisin
ET445_01145	ENOG4107R9S	Malate synthase
ET445_01235	ENOG4105CT4	transporter
ET445_01240	ENOG4105E2D	ec 3.2.1.52
ET445_01245	ENOG4107YPT	transcriptional regulator
ET445_01270	ENOG4105CDA	abc transporter atp-binding protein
ET445_01275	ENOG4105DRP	amino acid AbC transporter
ET445_01290	ENOG4105C26	Dehydrogenase
ET445_01300	ENOG4105VSY	K01512 acylphosphatase EC 3.6.1.7
ET445_01305	ENOG4105CHR	reductase
ET445_01310	ENOG4108IG5	Transcriptional regulator
ET445_01330	ENOG4105C1G	acyl-Coa dehydrogenase
ET445_01335	ENOG4105C64	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity)
ET445_01340	ENOG4108UIK	This protein binds directly to 23S ribosomal RNA (By similarity)
ET445_01375	ENOG4105C4Q	deoxyguanosinetriphosphate triphosphohydrolase-like protein
ET445_01395	ENOG4105CXD	Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity)
ET445_01415	ENOG4105GRZ	Ycii-related protein
ET445_01425	ENOG4105CCA	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity)
ET445_01440	ENOG4105BZU	Histidine kinase
ET445_01445	ENOG4105WH1	Two component transcriptional regulator luxr family
ET445_01450	ENOG4108M1A	Chitin-binding protein
ET445_01455	ENOG4108M1A	Chitin-binding protein
ET445_01460	ENOG4105C0X	amino acid
ET445_01465	ENOG4105WH1	Two component transcriptional regulator luxr family
ET445_01490	ENOG4107R4N	Cell wall formation (By similarity)
ET445_01500	ENOG410900P	UPF0336 protein
ET445_01510	ENOG4107R5M	Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity)
ET445_01515	ENOG4105E2K	Glycosyl transferase (Group 1
ET445_01520	ENOG4105D3Q	Sugar transferase
ET445_01610	ENOG4105C9B	Cysteine desulfurase
ET445_01615	ENOG4108UZX	fmn reductase
ET445_01620	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
ET445_01630	ENOG4105DQE	DNA ligase
ET445_01685	ENOG4108RVA	ribokinase
ET445_01695	ENOG4105DRS	transport system, permease
ET445_01705	ENOG4107FKK	extracellular solute-binding protein family 1
ET445_01730	ENOG4105CRD	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity)
ET445_01740	ENOG410804X	Transcriptional regulator
ET445_01760	ENOG4105EG2	ABC transporter, permease
ET445_01765	ENOG4105D56	permease protein
ET445_01770	ENOG4107FKK	extracellular solute-binding protein family 1
ET445_01775	ENOG4105CG3	alpha amylase, catalytic region
ET445_01780	ENOG4105DR5	peptidase
ET445_01790	ENOG4108KQ5	Integrase catalytic subunit
ET445_01810	ENOG4105ETE	Transcriptional regulator (LacI family
ET445_01820	ENOG4108VPT	UPF0234 protein
ET445_01845	ENOG4105EAH	synthase
ET445_01850	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
ET445_01860	ENOG4105E4F	Isochorismate synthase
ET445_01865	ENOG4105CSR	polyphosphate kinase 2
ET445_01870	ENOG4105C4A	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity)
ET445_01895	ENOG4107SIQ	Naphthoate synthase
ET445_01910	ENOG4105C3R	Methionine synthase
ET445_01915	ENOG4107TCW	O-succinylbenzoate synthase
ET445_01930	ENOG4105CRE	cytochrome C
ET445_01940	ENOG4107QIV	Cytochrome c biogenesis protein
ET445_01945	ENOG4105KJP	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
ET445_01950	ENOG4108RH7	phosphoglycerate mutase
ET445_01960	ENOG4105E6M	Sulphatase-modifying factor protein
ET445_01990	ENOG4107ZYR	domain protein
ET445_01995	ENOG4105CIG	ABC transporter
ET445_02000	ENOG4105DIM	ABC transporter
ET445_02020	ENOG4105DEI	Mannitol dehydrogenase
ET445_02030	ENOG4107P2S	Transcriptional regulator
ET445_02035	ENOG4105D2H	Uronic isomerase
ET445_02040	ENOG4105CXK	mandelate racemase muconate lactonizing
ET445_02085	ENOG4105C50	Binding-protein-dependent transport systems, inner membrane component
ET445_02090	ENOG4105I82	acetyl xylan esterase
ET445_02095	ENOG4107SFS	Catalyzes the formation of 5-methyl-uridine at position 747 (m5U747) in 23S rRNA (By similarity)
ET445_02100	ENOG4105E2D	ec 3.2.1.52
ET445_02105	ENOG4105II7	pyrroline-5-carboxylate reductase
ET445_02110	ENOG41076HS	cation diffusion facilitator family transporter
ET445_02115	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
ET445_02120	ENOG4108Z6B	deaminase
ET445_02125	ENOG4105CZ5	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity)
ET445_02130	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
ET445_02135	ENOG4105EQY	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity)
ET445_02140	ENOG4105WH1	Two component transcriptional regulator luxr family
ET445_02195	ENOG4107Y7Q	pfkb domain protein
ET445_02200	ENOG4107QN2	dihydrolipoyl dehydrogenase
ET445_02205	ENOG4105C0H	protease
ET445_02220	ENOG4105EX2	Binding-protein-dependent transport systems, inner membrane component
ET445_02230	ENOG4105BZ7	extracellular solute-binding protein family 1
ET445_02235	ENOG4105CG3	alpha amylase, catalytic region
ET445_02265	ENOG4105CYX	Short-chain dehydrogenase reductase Sdr
ET445_02285	ENOG4105FDF	Could be involved in DNA repair (By similarity)
ET445_02310	ENOG41061ZR	Transcriptional regulator
ET445_02315	ENOG4105ENH	Sulfatase
ET445_02320	ENOG4105E6M	Sulphatase-modifying factor protein
ET445_02325	ENOG4105C3E	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity)
ET445_02330	ENOG4107258	Transcriptional regulator
ET445_02390	ENOG4107P0T	Selenium-dependent molybdenum hydroxylase system protein, YqeB family
ET445_02410	ENOG4107TB5	TRANSCRIPTIONal
ET445_02420	ENOG4107TB5	TRANSCRIPTIONal
ET445_02425	ENOG4108KP7	hydrolase
ET445_02430	ENOG4105CGR	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity)
ET445_02435	ENOG4105CBD	Diacylglycerol kinase
ET445_02450	ENOG4105CQC	Prephenate dehydratase
ET445_02455	ENOG4106BRA	Membrane
ET445_02475	ENOG4108VXD	carboxy-peptidase
ET445_02490	ENOG4105EX2	Binding-protein-dependent transport systems, inner membrane component
ET445_02500	ENOG4105ETE	Transcriptional regulator (LacI family
ET445_02545	ENOG4105CEC	DNA methylase N-4 N-6
ET445_02555	ENOG4107S5Z	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity)
ET445_02565	ENOG4105CG3	alpha amylase, catalytic region
ET445_02570	ENOG4108RVA	ribokinase
ET445_02585	ENOG4107TYA	transient receptor potential locus
ET445_02590	ENOG4105CPQ	Dehydrogenase
ET445_02595	ENOG4105DRW	binding-protein-dependent transport systems inner membrane Component
ET445_02635	ENOG4105E98	transcriptional regulator DeoR family
ET445_02645	ENOG4107R37	Glutamate dehydrogenase
ET445_02655	ENOG4105F9U	Dehydrogenase
ET445_02665	ENOG4107R7Y	intracellular protease Pfpi family
ET445_02680	ENOG4105FDP	GntR family transcriptional regulator
ET445_02705	ENOG4105DAG	ROK family
ET445_02715	ENOG4107RTG	Major Facilitator superfamily
ET445_02720	ENOG4105DUX	Transporter
ET445_02750	ENOG410811P	TRANSCRIPTIONAl REGULATOR GntR family
ET445_02760	ENOG410811P	TRANSCRIPTIONAl REGULATOR GntR family
ET445_02765	ENOG4105D9I	Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity)
ET445_02770	ENOG4105D9I	Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity)
ET445_02775	ENOG4105C26	Dehydrogenase
ET445_02840	ENOG4105KVH	Transcriptional regulator
ET445_02865	ENOG4108W9H	Tetr family transcriptional regulator
ET445_02895	ENOG4105CR4	methylisocitrate lyase
ET445_02910	ENOG4108UNV	SUF system FeS assembly protein, NifU family
ET445_02915	ENOG4105E39	Enoyl-CoA hydratase
ET445_02920	ENOG410829K	Lysine exporter protein (Lyse ygga)
ET445_02930	ENOG4105C72	UPF0176 protein
ET445_02955	ENOG4105CJ1	ABC, transporter
ET445_02985	ENOG4105CDM	Glutamate-1-semialdehyde aminotransferase
ET445_02990	ENOG4105D52	delta-aminolevulinic acid dehydratase
ET445_03005	ENOG4107QME	Catalyzes the ferrous insertion into protoporphyrin IX (By similarity)
ET445_03040	ENOG4105DWH	electron transfer flavoprotein-ubiquinone oxidoreductase
ET445_03085	ENOG4105D9H	Catalyzes the attachment of glycine to tRNA(Gly) (By similarity)
ET445_03105	ENOG4105DMF	Dehydrogenase
ET445_03120	ENOG4105C9K	Endothelin-converting enzyme 1
ET445_03125	ENOG410901E	Membrane
ET445_03135	ENOG4105UQX	Mate efflux family protein
ET445_03150	ENOG4108W6C	Dehydrogenase
ET445_03155	ENOG4107EEK	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity)
ET445_03160	ENOG4105CPQ	Dehydrogenase
ET445_03180	ENOG41060BG	Tetr family transcriptional regulator
ET445_03200	ENOG4105CYV	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures (By similarity)
ET445_03205	ENOG41061TZ	Short-chain dehydrogenase reductase Sdr
ET445_03210	ENOG4108VXP	Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity)
ET445_03235	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
ET445_03250	ENOG4105BZ6	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity)
ET445_03270	ENOG4108V06	Glutathione peroxidase
ET445_03275	ENOG4105WH1	Two component transcriptional regulator luxr family
ET445_03295	ENOG4105C1I	TRANSCRIPTIONAl REGULATOR GntR family
ET445_03315	ENOG4105DBE	peroxidase
ET445_03320	ENOG410650H	(LipO)protein
ET445_03325	ENOG4105EKT	)-iron permease
ET445_03365	ENOG4105K56	Transcriptional regulator
ET445_03370	ENOG4105CF3	3-Hydroxyisobutyrate dehydrogenase
ET445_03395	ENOG4105I82	acetyl xylan esterase
ET445_03450	ENOG4107YCR	Transcriptional regulator, ARSR family
ET445_03460	ENOG4105DAB	fumarate reductase succinate dehydrogenase flavoprotein domain protein
ET445_03465	ENOG41061TZ	Short-chain dehydrogenase reductase Sdr
ET445_03510	ENOG4105C3M	thioredoxin reductase
ET445_03535	ENOG4105TVB	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity)
ET445_03550	ENOG4105CPC	Aldo Keto reductase
ET445_03560	ENOG4108KPJ	rna polymerase sigma factor
ET445_03565	ENOG4105K56	Transcriptional regulator
ET445_03570	ENOG4108YIQ	Alpha beta hydrolase
ET445_03575	ENOG4108KPJ	rna polymerase sigma factor
ET445_03610	ENOG41083TI	Protein CrcB homolog
ET445_03615	ENOG4107JBM	CrcB-like protein
ET445_03625	ENOG4105C1B	dTDP-glucose 4-6-dehydratase
ET445_03665	ENOG4105D7N	magnesium and cobalt transport protein CorA
ET445_03740	ENOG4105C0D	helicase
ET445_03785	ENOG4105HZM	Fha domain containing protein
ET445_03820	ENOG4108U4N	(sortase) family
ET445_03830	ENOG4107ZXI	Rhomboid family
ET445_03850	ENOG4105EJF	Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity)
ET445_03855	ENOG4105CPC	Aldo Keto reductase
ET445_03895	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
ET445_03900	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
ET445_03905	ENOG4105K7N	UPF0232 protein
ET445_03910	ENOG4105C3X	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity)
ET445_03915	ENOG4105CZ8	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity)
ET445_03920	ENOG4105CI4	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity)
ET445_03925	ENOG41084CH	50S ribosomal protein l34
ET445_03930	ENOG41067YR	RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity)
ET445_03935	ENOG4105VAS	Could be involved in insertion of integral membrane proteins into the membrane (By similarity)
ET445_03940	ENOG4105DHW	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
ET445_03950	ENOG4107XUG	Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity)
ET445_03955	ENOG4107QJE	Chromosome Partitioning Protein
ET445_03975	ENOG4105C1I	TRANSCRIPTIONAl REGULATOR GntR family
ET445_03980	ENOG4105K63	Thioredoxin
ET445_03985	ENOG4105C3M	thioredoxin reductase
ET445_04010	ENOG4105D4J	Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate
ET445_04015	ENOG410829C	Binds together with S18 to 16S ribosomal RNA (By similarity)
ET445_04025	ENOG4105VH8	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity)
ET445_04030	ENOG4105K9Q	Binds to the 23S rRNA (By similarity)
ET445_04040	ENOG4105CHR	reductase
ET445_04110	ENOG4105F4R	Transcriptional regulator mode
ET445_04115	ENOG4105CPC	Aldo Keto reductase
ET445_04135	ENOG4105BZ1	(ABC) transporter
ET445_04140	ENOG4105BZ1	(ABC) transporter
ET445_04145	ENOG4105W8V	TRANSCRIPTIONAl REGULATOR GntR family
ET445_04170	ENOG4107RNA	Nickel ABC transporter, periplasmic nickel-binding protein
ET445_04205	ENOG41061DF	Catalyzes the phosphorylation of N-acetylmannosamine (ManNAc) to ManNAc-6-P (By similarity)
ET445_04215	ENOG4105EQ7	Binding-protein-dependent transport systems, inner membrane component
ET445_04220	ENOG4105I1K	ABC transporter
ET445_04230	ENOG4108IIE	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity)
ET445_04235	ENOG4108IIE	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity)
ET445_04240	ENOG4105C15	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity)
ET445_04265	ENOG4107QTF	adenylosuccinate lyase
ET445_04270	ENOG4105KJF	protein tyrosine phosphatase
ET445_04290	ENOG41082T9	Membrane
ET445_04295	ENOG4105CIH	Imidazole acetol-phosphate transaminase
ET445_04315	ENOG4108IQK	o-acetylhomoserine
ET445_04335	ENOG4105DIK	(ABC) transporter
ET445_04340	ENOG4105CC5	ABC transporter
ET445_04360	ENOG4105W0E	50S ribosomal protein L33
ET445_04365	ENOG41080FR	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity)
ET445_04370	ENOG4108426	dNA-binding protein
ET445_04375	ENOG4105E4J	Cytochrome c oxidase caa3-type, assembly factor ctag-related protein
ET445_04385	ENOG4107QUV	Domain protein
ET445_04390	ENOG4107UQD	Hydrolyzes N-terminal residues in D-amino acid- containing peptides (By similarity)
ET445_04430	ENOG4105DHP	deoxycytidine triphosphate deaminase
ET445_04470	ENOG4107QK4	glycoside hydrolase, family 3 domain protein
ET445_04490	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
ET445_04505	ENOG4105CB8	Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity)
ET445_04510	ENOG4105EFS	Binding-protein-dependent transport systems, inner membrane component
ET445_04515	ENOG4108IY8	ABC, transporter
ET445_04535	ENOG4105ET3	Reduction of activated sulfate into sulfite (By similarity)
ET445_04540	ENOG4105ET1	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity)
ET445_04570	ENOG4105VMP	Transcriptional regulator
ET445_04590	ENOG4108PJD	permease
ET445_04595	ENOG4105CFG	Acts as a chaperone (By similarity)
ET445_04600	ENOG4108093	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
ET445_04605	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
ET445_04610	ENOG4105KNI	merR family transcriptional Regulator
ET445_04625	ENOG4105D8J	Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity)
ET445_04630	ENOG4105KEN	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity)
ET445_04645	ENOG4105EUZ	Beta-lactamase domain protein
ET445_04655	ENOG4105DSF	transport protein
ET445_04680	ENOG41065KQ	synthase
ET445_04685	ENOG4107RFD	Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity)
ET445_04720	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
ET445_04730	ENOG4105EBR	Carboxylesterase
ET445_04735	ENOG4105EV4	Multidrug resistance protein mdtH
ET445_04760	ENOG4105C5W	Aldolase
ET445_04770	ENOG4108IUX	(ABC) transporter
ET445_04780	ENOG41082W1	Cupin 2, conserved barrel domain protein
ET445_04785	ENOG4105WH1	Two component transcriptional regulator luxr family
ET445_04800	ENOG4105CHH	sulfate transporter
ET445_04850	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
ET445_04855	ENOG4105EFS	Binding-protein-dependent transport systems, inner membrane component
ET445_04865	ENOG4105D7T	ABC transporter
ET445_04870	ENOG4108IXY	short-chain dehydrogenase reductase
ET445_04875	ENOG4108ZI4	Glyoxalase Bleomycin resistance protein (Dioxygenase
ET445_04890	ENOG41088YA	Catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form coenzyme F420-0-glutamyl-glutamate (F420-2) or polyglutamated F420 derivatives (By similarity)
ET445_04895	ENOG41079Y2	Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone
ET445_04900	ENOG4105ME0	Guanylyltransferase that catalyzes the activation of 2- phospho-L-lactate (LP) as (2S)-lactyl-2-diphospho-5'-guanosine (LPPG), via the condensation of LP with GTP. Is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor (By similarity)
ET445_04905	ENOG41079Y2	Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone
ET445_04925	ENOG4105E0A	ABC, transporter
ET445_04930	ENOG4105EHG	Permease protein
ET445_04955	ENOG4105EIH	LPPG Fo 2-phospho-L-lactate transferase
ET445_04960	ENOG4105CSW	GntR family transcriptional regulator
ET445_04970	ENOG4107RNN	dihydropyrimidinase (EC 3.5.2.2)
ET445_04980	ENOG4105EUS	Binding-protein-dependent transport systems, inner membrane component
ET445_05000	ENOG4108JPX	Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity)
ET445_05005	ENOG4105C26	Dehydrogenase
ET445_05015	ENOG4105C5Q	Transcriptional regulator
ET445_05025	ENOG4105EC3	peptidase S51, dipeptidase E
ET445_05030	ENOG4105DS2	Anaerobic c4-dicarboxylate transporter
ET445_05040	ENOG41065E1	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity)
ET445_05055	ENOG4107RNA	Nickel ABC transporter, periplasmic nickel-binding protein
ET445_05115	ENOG4105C3M	thioredoxin reductase
ET445_05125	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
ET445_05135	ENOG4105CSV	Glutaminase
ET445_05160	ENOG4105D7N	magnesium and cobalt transport protein CorA
ET445_05180	ENOG4105CDH	Citrulline--aspartate ligase
ET445_05195	ENOG4105C91	Plays an important role in the de novo pathway of purine nucleotide biosynthesis
ET445_05220	ENOG4108NEV	two component transcriptional regulator, LytTR family
ET445_05225	ENOG4108HRK	Histidine kinase
ET445_05235	ENOG4107QN1	sodium solute
ET445_05240	ENOG41080V3	Major Facilitator superfamily
ET445_05245	ENOG4105D3W	isochorismatase
ET445_05265	ENOG4108594	Permease of the drug metabolite transporter
ET445_05270	ENOG4105FDP	GntR family transcriptional regulator
ET445_05275	ENOG4105DVE	abc transporter atp-binding protein
ET445_05285	ENOG4105EHE	chorismate mutase- prephenate dehydrogenase
ET445_05330	ENOG4107QIK	phosphoribosylformylglycinamidine synthase
ET445_05335	ENOG4105CEY	Amp-dependent synthetase and ligase
ET445_05350	ENOG4105E33	succinate dehydrogenase
ET445_05355	ENOG4107QP8	phosphohexose isomerase
ET445_05370	ENOG4107QPK	)-transporter
ET445_05380	ENOG4109003	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity)
ET445_05390	ENOG4105CWX	Alpha-1,2-mannosidase
ET445_05395	ENOG4107QWR	cellulase (EC 3.2.1.4)
ET445_05405	ENOG410839H	phosphoribosylformylglycinamidine synthase
ET445_05425	ENOG4105HJ8	Catalyzes the oxidative cleavage of the L-tryptophan (L- Trp) pyrrole ring (By similarity)
ET445_05435	ENOG4108TKW	Glyoxalase Bleomycin resistance protein (Dioxygenase
ET445_05445	ENOG4105C8V	SAICAR synthetase
ET445_05450	ENOG4107R4I	Periplasmic binding protein
ET445_05455	ENOG4105EHG	Permease protein
ET445_05460	ENOG4108IPX	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity)
ET445_05490	ENOG4105C12	Phosphoribosylglycinamide synthetase
ET445_05535	ENOG4105CBA	glutamine phosphoribosylpyrophosphate amidotransferase
ET445_05550	ENOG4105KA0	thioesterase Superfamily protein
ET445_05575	ENOG4105H3G	oxidoreductase
ET445_05585	ENOG4105G3Z	GntR family transcriptional regulator
ET445_05620	ENOG4108Z6Z	Transcriptional regulator
ET445_05685	ENOG4105CI2	imidazolone-5-propionate hydrolase
ET445_05690	ENOG4105CGP	Urocanate hydratase
ET445_05695	ENOG4105E4C	Lytic transglycosylase catalytic
ET445_05700	ENOG4105C84	Histidine ammonia-lyase
ET445_05710	ENOG4107T5V	SNARE associated Golgi
ET445_05720	ENOG4108XET	gCN5-related N-acetyltransferase
ET445_05750	ENOG4105CHR	reductase
ET445_05760	ENOG4105CHU	acetyl-coa acetyltransferase
ET445_05765	ENOG4105E39	Enoyl-CoA hydratase
ET445_05770	ENOG4105DYT	3-hydroxyacyl-CoA dehydrogenase
ET445_05775	ENOG4105DXM	phenylacetic acid degradation protein
ET445_05785	ENOG4105C9U	ATP-dependent DNA helicase RecQ
ET445_05810	ENOG41079Y2	Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone
ET445_05815	ENOG4108RZE	Tetr family transcriptional regulator
ET445_05825	ENOG4108ZJI	phenylacetic acid degradation protein
ET445_05830	ENOG4105CRS	phenylacetate-CoA oxygenase PaaG subunit
ET445_05835	ENOG4105N76	Phenylacetate-CoA oxygenase, subunit
ET445_05840	ENOG4108ZA2	phenylacetate-CoA oxygenase PaaJ subunit
ET445_05845	ENOG4105CJJ	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity)
ET445_05855	ENOG4105KJM	monovalent cation h antiporter subunit g
ET445_05860	ENOG41080TA	Multiple resistance and ph regulation protein f
ET445_05870	ENOG4108JPZ	Monovalent cation H antiporter subunit D
ET445_05875	ENOG4105MKQ	Monovalent cation H antiporter subunit C
ET445_05880	ENOG4105D65	subunit l
ET445_05890	ENOG4108V1T	peptidylprolyl cis-trans isomerase
ET445_05895	ENOG4105FEU	K -dependent Na -Ca exchanger
ET445_05915	ENOG4108W7F	transporter, permease
ET445_05920	ENOG4108JJB	ABC transporter
ET445_05930	ENOG4105DEN	Luciferase family
ET445_05955	ENOG4105FBW	Monooxygenase
ET445_05985	ENOG4105DWY	Agmatine deiminase
ET445_06010	ENOG4106PVI	ATP-dependent carboxylate-amine ligase (By similarity)
ET445_06035	ENOG4105DYT	3-hydroxyacyl-CoA dehydrogenase
ET445_06045	ENOG4105HFS	5'-3' exonuclease
ET445_06055	ENOG4105DKW	ABC transporter
ET445_06065	ENOG4105ECQ	AraC Family Transcriptional Regulator
ET445_06080	ENOG4105CCQ	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity)
ET445_06085	ENOG4105CCQ	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity)
ET445_06110	ENOG4108Z2X	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity)
ET445_06115	ENOG4105DWF	phosphomethylpyrimidine kinase
ET445_06120	ENOG4108UV6	Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity)
ET445_06125	ENOG4105C4U	4-methyl-5-beta-hydroxyethylthiazole kinase
ET445_06135	ENOG41065RQ	ADP-ribosylation crystallin J1
ET445_06170	ENOG4105M6F	mutator MutT protein
ET445_06225	ENOG4105CHP	RNA polymerase
ET445_06255	ENOG4105C0D	helicase
ET445_06270	ENOG4105WH1	Two component transcriptional regulator luxr family
ET445_06275	ENOG4105BZU	Histidine kinase
ET445_06305	ENOG4105WH1	Two component transcriptional regulator luxr family
ET445_06320	ENOG4105CSU	acyl-Coa dehydrogenase
ET445_06345	ENOG4105D17	glycoside hydrolase, family 3 domain protein
ET445_06350	ENOG4105ED7	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity)
ET445_06355	ENOG4105E15	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
ET445_06360	ENOG4106KNT	transcriptional regulator
ET445_06375	ENOG4105E9Z	Nad-dependent epimerase dehydratase
ET445_06395	ENOG4105CV8	reductase
ET445_06400	ENOG4105F27	Major Facilitator
ET445_06405	ENOG4108US0	Transcription regulator that can specifically activate or repress expression of target genes (By similarity)
ET445_06415	ENOG4105NPE	arsR family transcriptional regulator
ET445_06435	ENOG4106UW1	Major Facilitator superfamily
ET445_06460	ENOG4105C9U	ATP-dependent DNA helicase RecQ
ET445_06485	ENOG4105D9Z	Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity)
ET445_06505	ENOG4108RNG	Permease of the drug metabolite transporter
ET445_06535	ENOG4105VEQ	Cold shock protein
ET445_06555	ENOG4105CQB	FAD linked oxidase domain protein
ET445_06585	ENOG4105XPP	Protein of unknown function (DUF1275)
ET445_06640	ENOG4108IYT	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
ET445_06660	ENOG4105E4C	Lytic transglycosylase catalytic
ET445_06665	ENOG4105ZXU	NLP P60 protein
ET445_06670	ENOG4105F0N	pyrophosphate phospho-hydrolase
ET445_06675	ENOG4107RD1	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity)
ET445_06680	ENOG4108UGV	hypoxanthine phosphoribosyltransferase
ET445_06685	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
ET445_06690	ENOG4105EUJ	GTP cyclohydrolase i
ET445_06695	ENOG4105EEI	dihydropteroate synthase
ET445_06730	ENOG4107QQT	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity)
ET445_06735	ENOG4105CRK	lysyL-tRNA synthetase
ET445_06740	ENOG4105CQX	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity)
ET445_06755	ENOG4105VMP	Transcriptional regulator
ET445_06765	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
ET445_06790	ENOG4105DNJ	May play a role in the repair of endogenous alkylation damage (By similarity)
ET445_06805	ENOG4107QK4	glycoside hydrolase, family 3 domain protein
ET445_06890	ENOG4105C1J	atp-dependent rna helicase
ET445_06925	ENOG4105D8V	Glucose sorbosone dehydrogenase
ET445_06930	ENOG4105E7W	lamb ycsf family protein
ET445_06955	ENOG4107QIH	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
ET445_06960	ENOG4105D27	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
ET445_06965	ENOG4107QHF	type ii secretion system protein e
ET445_06970	ENOG4105CZX	twitching motility protein
ET445_07055	ENOG4105EC2	ftsk spoIIIe
ET445_07115	ENOG4108UKE	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity)
ET445_07120	ENOG4108UHY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity)
ET445_07125	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
ET445_07130	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
ET445_07140	ENOG4108Z10	Involved in the binding of tRNA to the ribosomes (By similarity)
ET445_07145	ENOG4105EEE	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity)
ET445_07150	ENOG4106U5A	One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity)
ET445_07155	ENOG4105KZR	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity)
ET445_07160	ENOG4105CFD	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
ET445_07165	ENOG4105K7S	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity)
ET445_07170	ENOG4105KAP	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity)
ET445_07175	ENOG4105CKE	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity)
ET445_07180	ENOG4108R70	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity)
ET445_07185	ENOG41082SA	50s ribosomal protein l29
ET445_07190	ENOG4105K87	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal
ET445_07195	ENOG4108UNN	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity)
ET445_07200	ENOG4105KAR	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity)
ET445_07205	ENOG4105CW6	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
ET445_07210	ENOG4108UJY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity)
ET445_07215	ENOG4108R5J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity)
ET445_07220	ENOG4105K4C	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity)
ET445_07225	ENOG4108RA9	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity)
ET445_07230	ENOG410849U	50S ribosomal protein L30
ET445_07240	ENOG4108UZ0	Binds to the 23S rRNA (By similarity)
ET445_07245	ENOG4105CGG	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity)
ET445_07250	ENOG4105CC8	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity)
ET445_07255	ENOG4105CA1	Removes the N-terminal methionine from nascent proteins (By similarity)
ET445_07260	ENOG410849S	phosphocarrier protein (HPr)
ET445_07275	ENOG4105JF0	Phosphoenolpyruvate-dependent sugar phosphotransferase system, eiia 2
ET445_07290	ENOG4105K9U	however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity)
ET445_07295	ENOG41067V7	50S ribosomal protein L36
ET445_07300	ENOG4108Z04	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
ET445_07305	ENOG4108UHH	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity)
ET445_07310	ENOG4105CTF	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
ET445_07315	ENOG4108ZT0	50S ribosomal protein l17
ET445_07325	ENOG4105DI7	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity)
ET445_07330	ENOG4108UM5	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity)
ET445_07335	ENOG4108UJD	30S ribosomal protein S9
ET445_07340	ENOG4107QJF	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity)
ET445_07345	ENOG4105CS9	pantothenic acid kinase
ET445_07350	ENOG4105C46	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity)
ET445_07355	ENOG41082KK	Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity)
ET445_07360	ENOG4105CJ4	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity)
ET445_07365	ENOG4108097	ATP-binding protein
ET445_07380	ENOG4105CPM	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
ET445_07400	ENOG4105K5Y	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity)
ET445_07415	ENOG4108IV0	ABC, transporter
ET445_07420	ENOG4105C0Z	ABC transporter
ET445_07425	ENOG4105CF8	branched-chain amino acid ABC transporter, permease
ET445_07430	ENOG4105C32	Amino acid ABC transporter (Permease)
ET445_07435	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
ET445_07450	ENOG4105C87	Aminotransferase class I and II
ET445_07460	ENOG4107QVP	Dehydrogenase
ET445_07480	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
ET445_07490	ENOG4105GRZ	Ycii-related protein
ET445_07495	ENOG4105CHP	RNA polymerase
ET445_07505	ENOG4106MZZ	glycerophosphoryl diester phosphodiesterase
ET445_07540	ENOG4106ZX3	phosphonate ABC transporter, periplasmic phosphonate-binding protein
ET445_07545	ENOG4105D5T	phosphonate abc transporter
ET445_07550	ENOG4105S7S	phosphonate abc transporter
ET445_07570	ENOG4105CMV	Succinyl-CoA synthetase subunit beta
ET445_07620	ENOG4105DC1	bifunctional purine biosynthesis protein purh
ET445_07625	ENOG4106V2I	dimethylaminohydrolase
ET445_07630	ENOG4105C19	ABC transporter
ET445_07635	ENOG4108EE5	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
ET445_07655	ENOG4105BZ1	(ABC) transporter
ET445_07660	ENOG4105CU5	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity)
ET445_07670	ENOG4105WH1	Two component transcriptional regulator luxr family
ET445_07675	ENOG4105ENE	Histidine kinase
ET445_07705	ENOG4105HS6	binding-protein-dependent transport systems inner membrane Component
ET445_07710	ENOG4105EG2	ABC transporter, permease
ET445_07715	ENOG4105D17	glycoside hydrolase, family 3 domain protein
ET445_07720	ENOG41061DF	Catalyzes the phosphorylation of N-acetylmannosamine (ManNAc) to ManNAc-6-P (By similarity)
ET445_07765	ENOG4105CE4	GlcNAc 6-P deacetylase
ET445_07770	ENOG4105E98	transcriptional regulator DeoR family
ET445_07775	ENOG4105D2N	Aldolase
ET445_07785	ENOG4105EVU	fructokinase
ET445_07790	ENOG4105C46	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity)
ET445_07810	ENOG4105E2D	ec 3.2.1.52
ET445_07815	ENOG4105E2D	ec 3.2.1.52
ET445_07820	ENOG4105C65	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity)
ET445_07825	ENOG4105CN0	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity)
ET445_07845	ENOG4105F0R	Cytidylyltransferase
ET445_07850	ENOG4105D2T	synthase
ET445_07860	ENOG4108Z0R	Transferase
ET445_07870	ENOG4105C90	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity)
ET445_07880	ENOG4107WI4	Aldose-1-epimerase
ET445_07950	ENOG4105BZY	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity)
ET445_07975	ENOG4105CUU	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity)
ET445_07980	ENOG4107NHD	transcriptional regulator
ET445_07990	ENOG4108X6U	May play a role in the intracellular transport of hydrophobic ligands
ET445_07995	ENOG4106XY2	Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity)
ET445_08005	ENOG4107RPC	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
ET445_08020	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
ET445_08035	ENOG4108UH8	Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity)
ET445_08040	ENOG4105C8N	cysteinyl-tRNA synthetase
ET445_08045	ENOG4105C2N	RNA methyltransferase TrmH family group 3
ET445_08080	ENOG4105E0X	reductase
ET445_08095	ENOG4105VEQ	Cold shock protein
ET445_08100	ENOG4108R5T	secreted protein
ET445_08115	ENOG4105BZU	Histidine kinase
ET445_08120	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
ET445_08130	ENOG4105EEI	dihydropteroate synthase
ET445_08140	ENOG4105CFI	type iii restriction protein res subunit
ET445_08155	ENOG4105VEQ	Cold shock protein
ET445_08170	ENOG4107R8H	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity)
ET445_08175	ENOG4107R5H	iron (metal) dependent repressor, dtxr family
ET445_08180	ENOG4107SN7	NLP P60 protein
ET445_08190	ENOG4105VRS	hydrolase family 18
ET445_08215	ENOG4108KQ5	Integrase catalytic subunit
ET445_08300	ENOG4105DCF	alanine dehydrogenase
ET445_08335	ENOG4105C3Y	UTP-glucose-1-phosphate uridylyltransferase
ET445_08365	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
ET445_08370	ENOG4105C9Y	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity)
ET445_08390	ENOG4105D0C	transport protein
ET445_08410	ENOG4105CV8	reductase
ET445_08420	ENOG4107YCR	Transcriptional regulator, ARSR family
ET445_08430	ENOG4105CQ7	ATP-dependent helicase
ET445_08455	ENOG4105C7Z	Conserved Protein
ET445_08475	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
ET445_08480	ENOG4105DFM	M18 family aminopeptidase
ET445_08515	ENOG4105K4P	CoA-binding domain protein
ET445_08535	ENOG4105D3W	isochorismatase
ET445_08540	ENOG4106Z1T	Nicotinamide Mononucleotide Transporter
ET445_08575	ENOG4105KPY	Small multidrug resistance protein
ET445_08585	ENOG4105VZ8	Transcriptional regulator
ET445_08600	ENOG4105FF9	glycosyl transferase, family 39
ET445_08620	ENOG4105F8V	Hydrolase, tatD family
ET445_08625	ENOG4105D1X	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity)
ET445_08635	ENOG4105CTR	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity)
ET445_08640	ENOG4105C5H	ABC transporter
ET445_08645	ENOG4105D8J	Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity)
ET445_08650	ENOG4105D01	(LipO)protein
ET445_08655	ENOG4108JEI	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity)
ET445_08660	ENOG4108UMI	ABC transporter, permease
ET445_08690	ENOG4105PDP	Short chain dehydrogenase
ET445_08705	ENOG4105CAJ	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity)
ET445_08715	ENOG4105CEY	Amp-dependent synthetase and ligase
ET445_08735	ENOG4105VG5	Membrane
ET445_08740	ENOG4105C7Q	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity)
ET445_08760	ENOG4105DRW	binding-protein-dependent transport systems inner membrane Component
ET445_08765	ENOG4105DW0	Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity)
ET445_08770	ENOG4105D2M	Aldolase
ET445_08775	ENOG4105MVE	transcriptional regulator
ET445_08780	ENOG4105C0C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity)
ET445_08785	ENOG4105C26	Dehydrogenase
ET445_08790	ENOG4105CHR	reductase
ET445_08830	ENOG4105CHR	reductase
ET445_08840	ENOG4105C57	major facilitator superfamily
ET445_08895	ENOG4106448	streptomycin biosynthesis protein strI
ET445_08900	ENOG4105D9R	oxidoreductase
ET445_08905	ENOG41061TZ	Short-chain dehydrogenase reductase Sdr
ET445_08930	ENOG4105DRI	Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity)
ET445_08940	ENOG4105CXK	mandelate racemase muconate lactonizing
ET445_08950	ENOG4105D2H	Uronic isomerase
ET445_08955	ENOG4105ETE	Transcriptional regulator (LacI family
ET445_08965	ENOG4105D9R	oxidoreductase
ET445_08975	ENOG4105DEI	Mannitol dehydrogenase
ET445_08980	ENOG4105CXK	mandelate racemase muconate lactonizing
ET445_08985	ENOG4108Z67	carbohydrate kinase, thermoresistant glucokinase family
ET445_08990	ENOG4107XT7	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity)
ET445_09015	ENOG4108ZPD	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity)
ET445_09045	ENOG4105DRC	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity)
ET445_09050	ENOG410829K	Lysine exporter protein (Lyse ygga)
ET445_09060	ENOG4105CUT	histidyl-tRNA synthetase
ET445_09075	ENOG4105C70	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity)
ET445_09105	ENOG4105F0F	Oxalate decarboxylase
ET445_09110	ENOG4107R33	ppx gppa phosphatase
ET445_09140	ENOG4105CIG	ABC transporter
ET445_09145	ENOG4108MHR	Repressor involved in choline regulation of the bet genes (By similarity)
ET445_09150	ENOG4108V0P	LemA family
ET445_09160	ENOG4105T0Z	Conserved Protein
ET445_09170	ENOG4105C7B	Threonine dehydratase
ET445_09175	ENOG4107YD5	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity)
ET445_09195	ENOG4105CR3	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity)
ET445_09205	ENOG4108IAB	Phoh family
ET445_09210	ENOG4105C9Q	fumarate hydratase class II
ET445_09225	ENOG4105YX8	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity)
ET445_09230	ENOG4105DVS	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity)
ET445_09235	ENOG4105C48	Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity)
ET445_09260	ENOG4107RCW	fructose-bisphosphate aldolase
ET445_09280	ENOG4105C9Y	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity)
ET445_09285	ENOG4108J59	Extracellular solute-binding protein, family 5
ET445_09295	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
ET445_09310	ENOG4105EBE	Peptidase U61, LD-carboxypeptidase A
ET445_09315	ENOG4105C9Y	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity)
ET445_09330	ENOG4105DTQ	mandelate racemase muconate lactonizing
ET445_09340	ENOG4105DE5	Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity)
ET445_09360	ENOG4105C3G	gtp-binding protein
ET445_09370	ENOG4108Z8G	Alkylphosphonate utilization operon protein PhnA
ET445_09415	ENOG4105C5H	ABC transporter
ET445_09465	ENOG4108ZT1	Transcriptional regulator
ET445_09470	ENOG4108KTG	Membrane protein, drug metabolite transporter
ET445_09540	ENOG4105EQY	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity)
ET445_09565	ENOG4107QI6	Cysteine desulfurase
ET445_09570	ENOG4105D18	nicotinate-nucleotide pyrophosphorylase
ET445_09575	ENOG4108IYU	L-aspartate oxidase
ET445_09580	ENOG4105D0I	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity)
ET445_09605	ENOG4105D43	The glycine cleavage system catalyzes the degradation of glycine (By similarity)
ET445_09610	ENOG4105KE9	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity)
ET445_09615	ENOG4105CBI	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
ET445_09635	ENOG4108J59	Extracellular solute-binding protein, family 5
ET445_09640	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
ET445_09645	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
ET445_09655	ENOG4105CI3	gtp-binding protein typa
ET445_09660	ENOG4105E4C	Lytic transglycosylase catalytic
ET445_09680	ENOG4108Z4U	Ferredoxin
ET445_09700	ENOG4105EJ3	Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2- amino-6-oxopimelate using succinyl-CoA (By similarity)
ET445_09705	ENOG4107R4C	succinyl-diaminopimelate desuccinylase
ET445_09725	ENOG4105UTW	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity)
ET445_09760	ENOG4105CJW	magnesium transporter
ET445_09770	ENOG4107T6F	Xaa-Pro aminopeptidase
ET445_09780	ENOG4105DB7	PHP domain protein
ET445_09785	ENOG4105C1J	atp-dependent rna helicase
ET445_09810	ENOG4105C4R	Atp-dependent dna helicase
ET445_09835	ENOG41063PX	domain protein
ET445_09840	ENOG4105DJZ	UPF0182 protein
ET445_09900	ENOG4105C5H	ABC transporter
ET445_09905	ENOG4105E1F	short-chain dehydrogenase reductase
ET445_09915	ENOG4105CPT	Alpha beta hydrolase
ET445_09925	ENOG4105C7K	acetolactate synthase
ET445_09935	ENOG4105CHR	reductase
ET445_09955	ENOG4105D7N	magnesium and cobalt transport protein CorA
ET445_09960	ENOG4107RPC	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
ET445_09965	ENOG4108YIQ	Alpha beta hydrolase
ET445_09970	ENOG4105EEM	helicase
ET445_09980	ENOG4107QPI	nitrilase cyanide hydratase and apolipoprotein n-acyltransferase
ET445_09990	ENOG4105C0H	protease
ET445_10015	ENOG410839S	Toxic component of a toxin-antitoxin (TA) module (By similarity)
ET445_10030	ENOG4105CVR	type I restriction-modification system
ET445_10070	ENOG4105EY8	ABC transporter
ET445_10115	ENOG4105F03	Provides the (R)-glutamate required for cell wall biosynthesis (By similarity)
ET445_10120	ENOG4105ED0	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity)
ET445_10125	ENOG4108V82	Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity)
ET445_10135	ENOG4107XFB	conserved TRANSMEMBRANE PROTEIN
ET445_10150	ENOG4108SQ9	flavin reductase domain protein, FMN-binding
ET445_10165	ENOG4107QWE	)-transporter
ET445_10225	ENOG4105KVH	Transcriptional regulator
ET445_10235	ENOG4105CG1	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity)
ET445_10240	ENOG4105CAK	Cell division ATP-binding protein ftsE
ET445_10250	ENOG4108UH4	Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity)
ET445_10270	ENOG4105DJB	Major Facilitator Superfamily
ET445_10290	ENOG4105TVJ	transport system, permease
ET445_10295	ENOG4105E0A	ABC, transporter
ET445_10300	ENOG4107SUZ	Sodium/hydrogen exchanger family
ET445_10305	ENOG4107TK4	histidinol-phosphate phosphatase
ET445_10340	ENOG4106S2D	Transcriptional regulator
ET445_10350	ENOG4108JU3	Alkyl hydroperoxide reductase
ET445_10360	ENOG4105EK6	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity)
ET445_10365	ENOG4108JJB	ABC transporter
ET445_10370	ENOG4107ZYJ	bioY protein
ET445_10390	ENOG4105EYF	MMPL domain protein
ET445_10395	ENOG4105C1K	alpha-alpha-trehalose-phosphate synthase
ET445_10400	ENOG4105C01	Dihydroxy-acid dehydratase
ET445_10405	ENOG4105C7K	acetolactate synthase
ET445_10410	ENOG4108ZP8	Acetolactate synthase small subunit
ET445_10415	ENOG4105C6M	Alpha-keto-beta-hydroxylacyl reductoisomerase
ET445_10435	ENOG4106N3A	copper homeostasis protein cutc
ET445_10465	ENOG4105CM2	brancheD-chain amino acid aminotransferase
ET445_10470	ENOG4108R6G	acetyltransferase
ET445_10475	ENOG4105ERH	Fumarylacetoacetate hydrolase
ET445_10485	ENOG4105CKY	Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively (By similarity)
ET445_10490	ENOG4105DDW	LysR family Transcriptional regulator
ET445_10495	ENOG4105C20	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity)
ET445_10545	ENOG4105DVT	helicase
ET445_10555	ENOG4108KQ5	Integrase catalytic subunit
ET445_10585	ENOG4105F44	Two component transcriptional regulator, winged helix family
ET445_10590	ENOG4106F60	Histidine kinase
ET445_10600	ENOG4108YIQ	Alpha beta hydrolase
ET445_10635	ENOG4105FDP	GntR family transcriptional regulator
ET445_10645	ENOG4105DFW	ABC transporter
ET445_10650	ENOG4105C2J	ABC transporter
ET445_10655	ENOG4105CNN	ABC, transporter
ET445_10660	ENOG4105CMG	Carbohydrate kinase
ET445_10665	ENOG4105C5I	Dehydrogenase
ET445_10670	ENOG4108UHU	Aldolase
ET445_10680	ENOG41080QX	K07048 phosphotriesterase-related protein
ET445_10715	ENOG4105C3M	thioredoxin reductase
ET445_10745	ENOG4108RYK	Nad-dependent epimerase dehydratase
ET445_10760	ENOG4105BZ4	penicillin-binding protein
ET445_10790	ENOG4108ZF3	Phosphatase
ET445_10820	ENOG4105C7R	Atpase associated with various cellular activities aaa_3
ET445_10840	ENOG4105CQI	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
ET445_10845	ENOG4105MQS	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
ET445_10850	ENOG4105CDF	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity)
ET445_10855	ENOG4105CEY	Amp-dependent synthetase and ligase
ET445_10860	ENOG4105CSF	NADPH-dependent glycerol-3-phosphate dehydrogenase
ET445_10865	ENOG4105CPF	Cell wall formation (By similarity)
ET445_10880	ENOG4106H78	methyltransferase
ET445_10890	ENOG4105CB5	ATP-dependent DNA helicase recG
ET445_10895	ENOG4108ZEF	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity)
ET445_10900	ENOG4105C7R	Atpase associated with various cellular activities aaa_3
ET445_10920	ENOG41062IY	50S ribosomal protein L32
ET445_10925	ENOG4108ZBM	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity)
ET445_10930	ENOG4105ERD	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity)
ET445_10940	ENOG4105CDB	Required for chromosome condensation and partitioning (By similarity)
ET445_10955	ENOG4105CB9	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
ET445_10980	ENOG4106KXD	ATP-dependent carboxylate-amine ligase (By similarity)
ET445_10985	ENOG4105K5M	30s ribosomal protein S16
ET445_10990	ENOG41084QK	UPF0109 protein
ET445_10995	ENOG4107XUM	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity)
ET445_11000	ENOG4105D6X	Specifically methylates guanosine-37 in various tRNAs (By similarity)
ET445_11020	ENOG4108YY1	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity)
ET445_11025	ENOG4107QYR	Signal peptidase i
ET445_11030	ENOG4108UH2	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
ET445_11040	ENOG41080R2	UPF0102 protein
ET445_11045	ENOG4105C0P	Mg chelatase subunit ChlI
ET445_11060	ENOG4108IYT	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
ET445_11070	ENOG4105CE9	30S ribosomal protein S2
ET445_11075	ENOG4105CU7	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity)
ET445_11085	ENOG4108VCV	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity)
ET445_11130	ENOG4105C9C	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity)
ET445_11135	ENOG4105EP6	Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB (By similarity)
ET445_11140	ENOG4108IUN	Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity)
ET445_11145	ENOG4108Z66	YbaK ebsC protein
ET445_11150	ENOG4108IUM	Glycogen debranching enzyme
ET445_11160	ENOG4105CCJ	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity)
ET445_11165	ENOG4105C77	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity)
ET445_11175	ENOG41081AP	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
ET445_11180	ENOG4105C3P	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity)
ET445_11185	ENOG4105CHT	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
ET445_11195	ENOG4107VJY	DNA polymerase
ET445_11205	ENOG4105NSK	ABC superfamily ATP binding cassette transporter membrane protein
ET445_11220	ENOG4105CAT	Cytidine monophosphate kinase
ET445_11245	ENOG4108RBP	3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity)
ET445_11255	ENOG4107RA1	nh(3)-dependent nad( ) synthetase
ET445_11270	ENOG4105CPC	Aldo Keto reductase
ET445_11305	ENOG4105C29	acyl-CoA thioesterase
ET445_11325	ENOG4105D8X	mechanosensitive ion channel
ET445_11335	ENOG4105WH1	Two component transcriptional regulator luxr family
ET445_11360	ENOG4107R3N	Filamentation induced by cAMP protein fic
ET445_11385	ENOG4105EFZ	amidohydrolase
ET445_11395	ENOG4105WH1	Two component transcriptional regulator luxr family
ET445_11400	ENOG4105DPV	During stationary phase, binds the chromosome non- specifically, forming a highly ordered and stable dps-DNA co- crystal within which chromosomal DNA is condensed and protected from diverse damages. It protects DNA from oxidative damage by sequestering intracellular Fe(2 ) ion and storing it in the form of Fe(3 ) oxyhydroxide mineral, which can be released after reduction. One hydrogen peroxide oxidizes two Fe(2 ) ions, which prevents hydroxyl radical production by the Fenton reaction
ET445_11405	ENOG4105WH1	Two component transcriptional regulator luxr family
ET445_11415	ENOG4107S75	HAD-superfamily hydrolase subfamily IA variant 3
ET445_11425	ENOG4105CMT	Dihydroxyacetone kinase
ET445_11445	ENOG4105DEA	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation
ET445_11455	ENOG4105CCQ	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity)
ET445_11460	ENOG4105CCQ	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity)
ET445_11465	ENOG4105CHN	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity)
ET445_11495	ENOG4107ZFB	This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity)
ET445_11515	ENOG4105C2V	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity)
ET445_11525	ENOG41067SE	Tetr family transcriptional regulator
ET445_11530	ENOG4105DYT	3-hydroxyacyl-CoA dehydrogenase
ET445_11535	ENOG4105CHU	acetyl-coa acetyltransferase
ET445_11540	ENOG4105ZIE	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity)
ET445_11580	ENOG4105D0C	transport protein
ET445_11605	ENOG4105C22	threonyL-tRNA synthetase
ET445_11620	ENOG4105CSW	GntR family transcriptional regulator
ET445_11625	ENOG4105CD9	Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity)
ET445_11630	ENOG4108UHX	Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity)
ET445_11645	ENOG4105CDY	transcriptional regulatory protein
ET445_11650	ENOG4105NHU	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity)
ET445_11655	ENOG4105KA4	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity)
ET445_11660	ENOG4105CKJ	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity)
ET445_11670	ENOG4107RSV	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
ET445_11675	ENOG4107RTU	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
ET445_11680	ENOG4105CWR	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity)
ET445_11715	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
ET445_11720	ENOG41080G3	Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity)
ET445_11730	ENOG4105E2X	shikimate dehydrogenase
ET445_11735	ENOG4105D10	5-enolpyruvylshikimate-3-phosphate phospholyase
ET445_11745	ENOG4105D49	3-dehydroquinate synthase
ET445_11750	ENOG4108Z38	Catalyzes a trans-dehydration via an enolate intermediate (By similarity)
ET445_11755	ENOG4105DRH	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity)
ET445_11760	ENOG410803B	Involved in the transcription termination process (By similarity)
ET445_11775	ENOG4108UK1	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity)
ET445_11780	ENOG4105CXT	aspartate transcarbamylase
ET445_11785	ENOG4105CD3	dihydroorotase
ET445_11795	ENOG4105C1M	carbamoyl-phosphate synthetase glutamine chain
ET445_11805	ENOG4105SKN	orotidine 5''-phosphate decarboxylase
ET445_11810	ENOG4108UHA	Essential for recycling GMP and indirectly, cGMP (By similarity)
ET445_11815	ENOG4105MTQ	Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity)
ET445_11825	ENOG4105CPH	Catalyzes the formation of S-adenosylmethionine from methionine and ATP
ET445_11835	ENOG4105CAE	Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity)
ET445_11845	ENOG4105DJV	ribulose-phosphate 3-epimerase
ET445_11850	ENOG4105M0N	phosphoribosyl-ATP pyrophosphatase
ET445_11855	ENOG4105E21	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity)
ET445_11860	ENOG4105C0S	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity)
ET445_11865	ENOG4105K8F	Phosphoribosyl-amp cyclohydrolase
ET445_11880	ENOG4105DK0	Indole-3-glycerol phosphate synthase
ET445_11885	ENOG4105CG0	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity)
ET445_11890	ENOG4105F6H	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity)
ET445_11895	ENOG4107SYZ	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity)
ET445_11900	ENOG4105CBC	glutamate synthase
ET445_11935	ENOG4105CAV	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity)
ET445_11945	ENOG4108ZQD	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity)
ET445_11950	ENOG4105CCW	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity)
ET445_11955	ENOG4105C5U	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity)
ET445_11960	ENOG4105CII	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity)
ET445_11965	ENOG4105C21	Displays ATPase and GTPase activities (By similarity)
ET445_11970	ENOG4105CIE	May be required for sporulation (By similarity)
ET445_11985	ENOG4105BZA	Phosphoglycerate kinase
ET445_11990	ENOG4105CP7	Triose-phosphate isomerase
ET445_12005	ENOG4107XU2	6-phosphogluconolactonase (EC 3.1.1.31)
ET445_12020	ENOG4105C89	phosphohexose isomerase
ET445_12025	ENOG4107QQX	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity)
ET445_12035	ENOG4105F1R	Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity)
ET445_12050	ENOG4105JRK	feS assembly protein SufD
ET445_12060	ENOG4105C3K	feS assembly ATPase SufC
ET445_12065	ENOG4105VG1	fes assembly suf system protein
ET445_12085	ENOG4105CA4	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity)
ET445_12095	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
ET445_12105	ENOG4107RNA	Nickel ABC transporter, periplasmic nickel-binding protein
ET445_12125	ENOG4105DPM	folylpolyglutamate synthase Dihydrofolate synthase
ET445_12145	ENOG4105C03	ribonuclease
ET445_12155	ENOG410826X	This protein binds to 23S rRNA in the presence of protein L20 (By similarity)
ET445_12160	ENOG4105K46	50S ribosomal protein l27
ET445_12165	ENOG4105C9R	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
ET445_12170	ENOG4105CGT	Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity)
ET445_12175	ENOG4105C2S	Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity)
ET445_12185	ENOG4108Z1W	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity)
ET445_12200	ENOG4108KQ5	Integrase catalytic subunit
ET445_12225	ENOG4105CPP	Dehydrogenase, E1 component
ET445_12235	ENOG4105EW9	transcriptional regulator AsnC family
ET445_12275	ENOG4105C5H	ABC transporter
ET445_12300	ENOG4108YV4	Universal stress protein
ET445_12305	ENOG4105EAC	phosphoserine phosphatase
ET445_12315	ENOG4107QPH	glycogen) synthase
ET445_12320	ENOG4105DKW	ABC transporter
ET445_12325	ENOG4105NRA	50s ribosomal protein l31 type b
ET445_12335	ENOG4105D74	hydrolase
ET445_12345	ENOG4105CVJ	phosphoglycerate mutase
ET445_12390	ENOG4107T8P	acyl-Coa dehydrogenase
ET445_12400	ENOG4107R7I	amino acid
ET445_12405	ENOG4105EW9	transcriptional regulator AsnC family
ET445_12425	ENOG4108YIQ	Alpha beta hydrolase
ET445_12430	ENOG4105C0B	DNA polymerase III (alpha subunit)
ET445_12465	ENOG4105C9Y	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity)
ET445_12470	ENOG4105DWR	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity)
ET445_12510	ENOG4105DCX	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity)
ET445_12525	ENOG4105Q70	
ET445_12530	ENOG4107VXM	glycerophosphoryl diester phosphodiesterase
ET445_12545	ENOG4105CYX	Short-chain dehydrogenase reductase Sdr
ET445_12565	ENOG4105C5U	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity)
ET445_12575	ENOG4105RHY	Pfam:UPF0157
ET445_12605	ENOG4106HV3	Cell surface-associated protein implicated in virulence. Promotes bacterial attachment exclusively to the gamma-chain of human fibrinogen. Induces formation of bacterial clumps
ET445_12635	ENOG4105H9W	Short-chain dehydrogenase reductase Sdr
ET445_12645	ENOG4108UTZ	Dihydroxyacetone kinase
ET445_12650	ENOG4105CMT	Dihydroxyacetone kinase
ET445_12655	ENOG4105D8C	Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity)
ET445_12660	ENOG4107QVN	Key enzyme in the regulation of glycerol uptake and metabolism (By similarity)
ET445_12665	ENOG4107S1N	anthranilate phosphoribosyltransferase
ET445_12670	ENOG4105CCU	oxidase (Subunit III)
ET445_12675	ENOG4107UDY	cytochrome C
ET445_12680	ENOG4107EUI	c reductase, iron-sulfur
ET445_12685	ENOG4105DJ5	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity)
ET445_12695	ENOG4108ZRS	Part of cytochrome c oxidase, its function is
ET445_12700	ENOG4105BZ9	Cytochrome C oxidase, subunit I
ET445_12705	ENOG4105CV4	Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity)
ET445_12715	ENOG4105C9Y	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity)
ET445_12735	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
ET445_12750	ENOG4105DMZ	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity)
ET445_12755	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
ET445_12765	ENOG4105BZ6	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity)
ET445_12785	ENOG4108BDP	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity)
ET445_12790	ENOG4105C0G	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity)
ET445_12805	ENOG4105C5F	glutamine synthetase
ET445_12810	ENOG4105CE6	Adenylation and deadenylation of glutamate--ammonia ligase (By similarity)
ET445_12820	ENOG4105CCG	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity)
ET445_12845	ENOG4105EGD	dinuclear metal center protein, YbgI family
ET445_12885	ENOG4105DAQ	Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity)
ET445_12900	ENOG4105CCZ	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity)
ET445_12905	ENOG41082KT	Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity)
ET445_12910	ENOG4105C0Q	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity)
ET445_12980	ENOG4108Z02	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity)
ET445_12995	ENOG4107RFD	Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity)
ET445_13010	ENOG4108JEI	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity)
ET445_13025	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
ET445_13035	ENOG4105C9G	DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity)
ET445_13040	ENOG4105C4Q	deoxyguanosinetriphosphate triphosphohydrolase-like protein
ET445_13055	ENOG4107ZXU	DSBA oxidoreductase
ET445_13065	ENOG4105CR3	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity)
ET445_13075	ENOG4105EN6	Membrane
ET445_13090	ENOG4105E9V	Periplasmic binding protein LacI transcriptional regulator
ET445_13095	ENOG4105C2J	ABC transporter
ET445_13100	ENOG4105CNN	ABC, transporter
ET445_13110	ENOG4107QXN	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity)
ET445_13115	ENOG4107R34	abc transporter permease protein
ET445_13120	ENOG4105C19	ABC transporter
ET445_13125	ENOG4105WH1	Two component transcriptional regulator luxr family
ET445_13130	ENOG4105BZU	Histidine kinase
ET445_13135	ENOG4105CWT	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity)
ET445_13145	ENOG4107VNR	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity)
ET445_13165	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
ET445_13170	ENOG4105CI8	Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity)
ET445_13210	ENOG4105PMW	Domain of unknown function (DUF1990)
ET445_13225	ENOG4105KQV	Binds directly to 16S ribosomal RNA (By similarity)
ET445_13255	ENOG4105C8T	Leucyl-tRNA synthetase
ET445_13265	ENOG4108JJ8	(ABC) transporter
ET445_13275	ENOG4105CFY	cytochrome d ubiquinol oxidase, subunit ii
ET445_13280	ENOG4105C4M	(Ubiquinol oxidase) subunit I
ET445_13295	ENOG4107XFB	conserved TRANSMEMBRANE PROTEIN
ET445_13300	ENOG4107SI7	Substrate-binding region of abc-type glycine betaine transport system
ET445_13305	ENOG4105E90	ABC transporter
ET445_13310	ENOG4105E90	ABC transporter
ET445_13320	ENOG4105EC0	Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity)
ET445_13330	ENOG4107QYT	Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity)
ET445_13335	ENOG4108Z11	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity)
ET445_13340	ENOG4105CEK	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity)
ET445_13345	ENOG4105C0B	DNA polymerase III (alpha subunit)
ET445_13370	ENOG4105VR5	Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity)
ET445_13375	ENOG4105DFA	alanine racemase domain protein
ET445_13380	ENOG4105CDK	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity)
ET445_13395	ENOG4105DVQ	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity)
ET445_13405	ENOG4105DMZ	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity)
ET445_13410	ENOG4105CPY	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity)
ET445_13420	ENOG4107EEN	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity)
ET445_13425	ENOG4105CJN	penicillin-binding protein
ET445_13435	ENOG4105CGJ	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity)
ET445_13460	ENOG41068JE	domain protein
ET445_13470	ENOG4105C7V	phospho-2-dehydro-3-deoxyheptonate aldolase
ET445_13475	ENOG4105E9Q	Acyl-transferase
ET445_13480	ENOG4105DKQ	ROK family
ET445_13500	ENOG4108JIJ	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity)
ET445_13520	ENOG4108UW8	fha domain-containing protein
ET445_13535	ENOG4108JW7	Maf-like protein
ET445_13560	ENOG4105K5B	UPF0225 protein
ET445_13595	ENOG4108Z4X	TRANSCRIPTIONal
ET445_13600	ENOG4108Z4U	Ferredoxin
ET445_13635	ENOG4105ETE	Transcriptional regulator (LacI family
ET445_13655	ENOG41061ZR	Transcriptional regulator
ET445_13685	ENOG4107XHQ	chlorophyll synthesis pathway, bchC
ET445_13695	ENOG4107R5M	Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity)
ET445_13705	ENOG4105D1W	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity)
ET445_13725	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
ET445_13785	ENOG4105DZR	Type I site-specific deoxyribonuclease
ET445_13835	ENOG4105E1F	short-chain dehydrogenase reductase
ET445_13960	ENOG41063C6	UPF0235 protein
ET445_13965	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
ET445_13970	ENOG4105DKZ	GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity)
ET445_13975	ENOG4105CAT	Cytidine monophosphate kinase
ET445_13990	ENOG4105K8I	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity)
ET445_13995	ENOG4108KVX	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity)
ET445_14010	ENOG4108YZ4	nudix hydrolase
ET445_14015	ENOG4105C8D	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity)
ET445_14020	ENOG4105C4F	May be involved in recombinational repair of damaged DNA (By similarity)
ET445_14025	ENOG4105F91	Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity)
ET445_14040	ENOG4105DSU	hydrolase
ET445_14060	ENOG4108MXC	l-carnitine dehydratase bile acid-inducible protein F
ET445_14065	ENOG4105DA0	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity)
ET445_14080	ENOG4108VX5	3-methyladenine DNA glycosylase
ET445_14085	ENOG4105CH7	arginosuccinase
ET445_14090	ENOG4105DBV	ornithine carbamoyltransferase
ET445_14105	ENOG4105C5V	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity)
ET445_14110	ENOG4105C0N	N-acetylglutamate semialdehyde dehydrogenase
ET445_14120	ENOG4105C6A	phenylalanyl-tRNA synthetase (beta subunit)
ET445_14125	ENOG4105CSS	phenylalanyl-tRNA synthetase (alpha subunit)
ET445_14130	ENOG4105DRP	amino acid AbC transporter
ET445_14135	ENOG4108Q1T	ABC transporter
ET445_14145	ENOG4105CDA	abc transporter atp-binding protein
ET445_14150	ENOG4108RWN	rrna methyltransferase
ET445_14155	ENOG4108YZX	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity)
ET445_14165	ENOG4108UUX	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity)
ET445_14175	ENOG4108S0J	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, 5,6-dihydrouracil and 5,6-dihydrothymine. Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'- phosphates (By similarity)
ET445_14195	ENOG4105CJV	Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase
ET445_14200	ENOG4108UJE	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity)
ET445_14205	ENOG4105ECC	imidazole-glycerol-phosphate dehydratase
ET445_14220	ENOG4105DS7	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity)
ET445_14225	ENOG410832A	alpha/beta hydrolase fold
ET445_14230	ENOG4107QYE	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity)
ET445_14240	ENOG4105C1N	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity)
ET445_14245	ENOG4107Y49	methyltransferase
ET445_14250	ENOG4105E4Z	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity)
ET445_14255	ENOG4105DKX	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity)
ET445_14260	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
ET445_14270	ENOG4105C68	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity)
ET445_14285	ENOG4105CEV	competence damage-inducible protein
ET445_14295	ENOG4107QZI	cell division protein FtsK
ET445_14300	ENOG4105KEG	ribosomal-protein-alanine acetyltransferase
ET445_14305	ENOG4107RBB	ABC transporter, permease
ET445_14325	ENOG4105CN5	Metallo-Beta-Lactamase
ET445_14330	ENOG4105CDP	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity)
ET445_14345	ENOG4105C0V	Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity)
ET445_14375	ENOG4105DUK	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity)
ET445_14390	ENOG4105C1V	Peptidase, M16
ET445_14395	ENOG4105CPC	Aldo Keto reductase
ET445_14410	ENOG4105C1G	acyl-Coa dehydrogenase
ET445_14420	ENOG4107QX3	carboxylase
ET445_14435	ENOG4108IG5	Transcriptional regulator
ET445_14440	ENOG4105KZX	Pterin carbinolamine dehydratase
ET445_14445	ENOG4107RN0	branched-chain alpha-keto acid dehydrogenase subunit E2
ET445_14450	ENOG4105CPP	Dehydrogenase, E1 component
ET445_14465	ENOG4107FW0	short-chain dehydrogenase reductase
ET445_14470	ENOG4108TCJ	secreted hydrolase
ET445_14475	ENOG4105C62	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity)
ET445_14525	ENOG41080RH	Thioredoxin
ET445_14545	ENOG4105K77	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity)
ET445_14555	ENOG4105F95	Monooxygenase
ET445_14570	ENOG4105K78	MarR family Transcriptional regulator
ET445_14575	ENOG4105F1A	Pyruvate formate-lyase
ET445_14590	ENOG4105D4Y	metalloprotease
ET445_14600	ENOG4105E99	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity)
ET445_14615	ENOG41081K0	peptidylprolyl cis-trans isomerase
ET445_14625	ENOG4105CQB	FAD linked oxidase domain protein
ET445_14635	ENOG4107YCY	Transcriptional regulator
ET445_14655	ENOG4105NWF	RbsD or FucU transport
ET445_14670	ENOG4105DIA	mandelate racemase muconate lactonizing
ET445_14675	ENOG4105ERH	Fumarylacetoacetate hydrolase
ET445_14690	ENOG4108IJ0	Aspartate ammonia-lyase
ET445_14700	ENOG4105C2W	permease
ET445_14705	ENOG4105C7N	Xanthine uracil vitamin C permease
ET445_14720	ENOG4108BDP	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity)
ET445_14755	ENOG4105VPX	protein, conserved in bacteria
ET445_14770	ENOG4105C26	Dehydrogenase
ET445_14775	ENOG4105C26	Dehydrogenase
ET445_14780	ENOG4105FCI	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity)
ET445_14785	ENOG4107RHR	regulatoR
ET445_14800	ENOG4105DJ2	Major Facilitator Superfamily
ET445_14805	ENOG4105DTN	riboflavin biosynthesis protein ribF
ET445_14820	ENOG4105D0T	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity)
ET445_14825	ENOG4108JZF	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity)
ET445_14855	ENOG41076PI	Short-chain dehydrogenase reductase Sdr
ET445_14860	ENOG4107ZPY	Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity)
ET445_14865	ENOG4107QHU	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity)
ET445_14875	ENOG4105CHV	Transcription elongation factor NusA
ET445_14880	ENOG4108URH	decarboxylase
ET445_14885	ENOG4105C90	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity)
ET445_14900	ENOG4105C4E	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity)
ET445_14905	ENOG41074FZ	May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity)
ET445_14935	ENOG4105CEY	Amp-dependent synthetase and ligase
ET445_14940	ENOG4105C32	Amino acid ABC transporter (Permease)
ET445_14945	ENOG4108IV0	ABC, transporter
ET445_14950	ENOG4105C0Z	ABC transporter
ET445_14960	ENOG4105CHU	acetyl-coa acetyltransferase
ET445_14975	ENOG4105DRC	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity)
ET445_15000	ENOG4105WH1	Two component transcriptional regulator luxr family
ET445_15005	ENOG4105BZU	Histidine kinase
ET445_15010	ENOG4105DZP	Membrane-associated zinc metalloprotease
ET445_15015	ENOG4105CEA	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity)
ET445_15050	ENOG4105D38	putrescine abc transporter
ET445_15055	ENOG4105F38	ABC transporter, permease
ET445_15060	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
ET445_15070	ENOG4105EC2	ftsk spoIIIe
ET445_15105	ENOG4108ZF3	Phosphatase
ET445_15120	ENOG4108JPX	Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity)
ET445_15125	ENOG4105CJP	fad dependent oxidoreductase
ET445_15135	ENOG4107SET	aldo keto reductase
ET445_15140	ENOG4108R3E	Dna-3-methyladenine glycosylase i
ET445_15155	ENOG410825K	Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity)
ET445_15160	ENOG4105C4J	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity)
ET445_15165	ENOG4105J80	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity)
ET445_15170	ENOG4105CDG	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity)
ET445_15175	ENOG4108T62	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
ET445_15180	ENOG4107Z0K	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity)
ET445_15190	ENOG4107UH5	it plays a direct role in the translocation of protons across the membrane (By similarity)
ET445_15200	ENOG4105ESV	Glycosyl transferase, family 4
ET445_15230	ENOG4105EQY	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity)
ET445_15240	ENOG4105D7W	serine acetyltransferase
ET445_15250	ENOG4105C8K	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity)
ET445_15260	ENOG4105D5I	Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity)
ET445_15270	ENOG4105D6E	homoserine dehydrogenase
ET445_15275	ENOG4105CU5	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity)
ET445_15290	ENOG4108NZE	NAGC-like transcriptional regulator
ET445_15305	ENOG4105NAF	rna polymerase sigma factor
ET445_15320	ENOG41087YS	Phage shock protein A
ET445_15325	ENOG41066UZ	arginase EC 3.5.3.1
ET445_15355	ENOG4105E0A	ABC, transporter
ET445_15360	ENOG4105TVJ	transport system, permease
ET445_15365	ENOG4105DQ5	transport system permease protein
ET445_15385	ENOG4105D5S	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity)
ET445_15415	ENOG4105DWV	Homoserine O-trans-acetylase
ET445_15465	ENOG4105E5Q	amino acid AbC transporter
ET445_15470	ENOG4105CDA	abc transporter atp-binding protein
ET445_15480	ENOG4105EJU	HAD-superfamily hydrolase subfamily IA variant 3
ET445_15485	ENOG4105CCY	NADH flavin oxidoreductase, NADH oxidase
ET445_15515	ENOG4105C19	ABC transporter
ET445_15525	ENOG4105C7P	2-oxoglutarate dehydrogenase, E1
ET445_15535	ENOG4105EMN	RNA polymerase sigma factor
ET445_15540	ENOG4105CMY	5-enolpyruvylshikimate-3-phosphate synthase
ET445_15545	ENOG4105E06	May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity)
ET445_15560	ENOG4105KRM	Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity)
ET445_15595	ENOG4105CI6	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving
ET445_15600	ENOG4108S7Q	sigma 54 modulation protein ribosomal protein S30ea
ET445_15605	ENOG4105MJ2	Competence protein
ET445_15610	ENOG4108T3R	lipoprotein lpqB
ET445_15615	ENOG4105BZU	Histidine kinase
ET445_15635	ENOG4108WQ6	secreted protein
ET445_15640	ENOG4105C7R	Atpase associated with various cellular activities aaa_3
ET445_15650	ENOG4105D8C	Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity)
ET445_15665	ENOG4105C3E	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity)
ET445_15680	ENOG4105CPQ	Dehydrogenase
ET445_15685	ENOG4107QKV	phosphomannomutase
ET445_15710	ENOG4105K51	Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity)
ET445_15715	ENOG4105CMR	udp-glucose 4-epimerase
ET445_15720	ENOG4105ECQ	AraC Family Transcriptional Regulator
ET445_15725	ENOG4105EIP	mannose-6-phosphate isomerase
ET445_15730	ENOG4105C1G	acyl-Coa dehydrogenase
ET445_15755	ENOG4105DAF	Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
ET445_15765	ENOG4105DRI	Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity)
ET445_15770	ENOG4106N3V	dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83)
ET445_15780	ENOG4105CND	Glycosyl transferase, family 2
ET445_15800	ENOG4105CKK	Glycosyl transferase, family 2
ET445_15830	ENOG4105EY8	ABC transporter
ET445_15835	ENOG4108IAJ	Nad-dependent epimerase dehydratase
ET445_15855	ENOG4105CUI	Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity)
ET445_15885	ENOG4105C1B	dTDP-glucose 4-6-dehydratase
ET445_15890	ENOG4105DBZ	Dtdp-4-dehydrorhamnose reductase
ET445_15900	ENOG4108KGH	TRANSCRIPTIONal
ET445_15940	ENOG4105D8K	carboxyl transferase
ET445_15965	ENOG4105BZT	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity)
ET445_15970	ENOG4107WR6	Maf-like protein
ET445_15975	ENOG4108JIK	carboxylase
ET445_16000	ENOG4105CUB	amino acid
ET445_16015	ENOG4107QSU	Phosphoglucomutase phosphomannomutase alpha beta alpha domain
ET445_16030	ENOG4105EKD	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity)
ET445_16050	ENOG4105UIB	(ABC) transporter
ET445_16055	ENOG4108JQ9	ABC transporter
ET445_16060	ENOG4105DIH	basic membrane
ET445_16065	ENOG4105DIH	basic membrane
ET445_16090	ENOG4105E33	succinate dehydrogenase
ET445_16110	ENOG4105CGK	Exodeoxyribonuclease III
ET445_16115	ENOG4105C31	Tryptophanyl-tRNA synthetase
ET445_16120	ENOG4105U0R	haloacid dehalogenase-like hydrolase
ET445_16125	ENOG4105C6V	Glycerol-3-phosphate dehydrogenase
ET445_16130	ENOG4107RHR	regulatoR
ET445_16140	ENOG4105NTW	Transcriptional regulator
ET445_16155	ENOG4105C66	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity)
ET445_16160	ENOG4108UTT	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity)
ET445_16170	ENOG4105CSH	Transporter
ET445_16215	ENOG4105C0M	Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle (By similarity)
ET445_16240	ENOG4105CHU	acetyl-coa acetyltransferase
ET445_16275	ENOG4105JSC	dimethylmenaquinone methyltransferase
ET445_16285	ENOG4105C26	Dehydrogenase
ET445_16305	ENOG4108RWI	nicotinamidase
ET445_16365	ENOG4105C73	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity)
ET445_16410	ENOG4108UW5	maltose o-acetyltransferase
ET445_16415	ENOG4107EF8	Glycosyl transferase (Group 1
ET445_16465	ENOG4107RCI	amp-dependent synthetase and ligase
ET445_16470	ENOG4107RCI	amp-dependent synthetase and ligase
ET445_16475	ENOG4107RCI	amp-dependent synthetase and ligase
ET445_16500	ENOG4105D3Q	Sugar transferase
ET445_16505	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
ET445_16525	ENOG4105BZ4	penicillin-binding protein
ET445_16540	ENOG4105C6Y	Udp-glucose 6-dehydrogenase
ET445_16630	ENOG4105KJF	protein tyrosine phosphatase
ET445_16635	ENOG4107YJ4	chain length determinant protein
ET445_16645	ENOG4107104	thymidine kinase
ET445_16675	ENOG4105DWT	malate dehydrogenase (quinone)
ET445_16685	ENOG4105F8D	glycoside hydrolase family 4
ET445_16690	ENOG4105E2R	ROK family
ET445_16695	ENOG4108JQ7	(ABC) transporter
ET445_16710	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
ET445_16730	ENOG4107HP6	Transcriptional regulator
ET445_16740	ENOG4108W9Q	Endoglucanase (EC 3.2.1.4)
ET445_16765	ENOG4105BZU	Histidine kinase
ET445_16775	ENOG4105CFH	Aspartokinase
ET445_16790	ENOG4105F3K	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity)
ET445_16800	ENOG4108V7X	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
ET445_16815	ENOG4105C6H	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity)
ET445_16830	ENOG4105C09	Bile acid
ET445_16850	ENOG4108KQ5	Integrase catalytic subunit
ET445_16865	ENOG4108ZBR	Gcn5-related n-acetyltransferase
ET445_16870	ENOG4105D7A	ATP-binding protein
ET445_16905	ENOG4108YXW	Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
ET445_16915	ENOG4105CM1	Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
ET445_16920	ENOG4108ZAF	Molybdopterin
ET445_16925	ENOG4108YXW	Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
ET445_16940	ENOG4105DTQ	mandelate racemase muconate lactonizing
ET445_16960	ENOG4105QE3	oxidoreductase
ET445_16970	ENOG4105C2C	drug resistance transporter, Bcr CflA
ET445_16985	ENOG4105EQ7	Binding-protein-dependent transport systems, inner membrane component
ET445_16990	ENOG4105DRW	binding-protein-dependent transport systems inner membrane Component
ET445_17005	ENOG4105C93	Xylose Isomerase
ET445_17015	ENOG4105D9F	endo-1,4-beta-xylanase (EC 3.2.1.8)