locus-tag	class	description
C7S18_00075	COG3668	Plasmid stabilization system
C7S18_00090	COG3039	Transposase
C7S18_00140	COG1278	Cold shock
C7S18_00180	COG3483	tryptophan 2,3-dioxygenase activity
C7S18_00195	COG3220	belongs to the UPF0276 family
C7S18_00205	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
C7S18_00210	COG2199	diguanylate cyclase activity
C7S18_00215	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
C7S18_00220	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C7S18_00225	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
C7S18_00245	COG4245	von Willebrand factor, type A
C7S18_00250	COG0631	protein serine/threonine phosphatase activity
C7S18_00255	COG4248	protein with protein kinase and helix-hairpin-helix DNA-binding domains
C7S18_00260	COG4248	protein with protein kinase and helix-hairpin-helix DNA-binding domains
C7S18_00275	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
C7S18_00280	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
C7S18_00285	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C7S18_00305	COG2423	ornithine cyclodeaminase activity
C7S18_00345	COG0463	Glycosyl transferase, family 2
C7S18_00360	COG2203	Gaf domain
C7S18_00360	COG5001	Diguanylate cyclase
C7S18_00360	COG4251	negative regulation of phosphorylation
C7S18_00360	COG3706	GGDEF domain
C7S18_00365	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
C7S18_00370	COG2224	Isocitrate lyase
C7S18_00385	COG1862	Preprotein translocase
C7S18_00395	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C7S18_00415	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C7S18_00420	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
C7S18_00440	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
C7S18_00450	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C7S18_00455	COG0175	sulfate reduction
C7S18_00460	COG2046	Belongs to the sulfate adenylyltransferase family
C7S18_00460	COG0529	Catalyzes the synthesis of activated sulfate
C7S18_00480	COG0463	Glycosyl transferase, family 2
C7S18_00485	COG2267	carboxylic ester hydrolase activity
C7S18_00505	COG2409	Drug exporters of the RND superfamily
C7S18_00530	COG1404	Belongs to the peptidase S8 family
C7S18_00540	COG1028	Short-chain dehydrogenase reductase Sdr
C7S18_00570	COG0288	reversible hydration of carbon dioxide
C7S18_00580	COG4122	O-methyltransferase activity
C7S18_00600	COG0116	Belongs to the methyltransferase superfamily
C7S18_00600	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
C7S18_00640	COG0515	serine threonine protein kinase
C7S18_00700	COG0515	serine threonine protein kinase
C7S18_00700	COG2815	serine threonine protein kinase
C7S18_00715	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
C7S18_00730	COG0513	Belongs to the DEAD box helicase family
C7S18_00735	COG0823	Involved in the tonB-independent uptake of proteins
C7S18_00740	COG1794	racemase activity, acting on amino acids and derivatives
C7S18_00760	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
C7S18_00770	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
C7S18_00780	COG3541	Predicted nucleotidyltransferase
C7S18_00800	COG2226	methyltransferase
C7S18_00805	COG2755	lipolytic protein G-D-S-L family
C7S18_00845	COG0457	Tetratricopeptide repeat
C7S18_00845	COG0515	serine threonine protein kinase
C7S18_00855	COG1940	carbohydrate kinase activity
C7S18_00870	COG0427	acetyl-CoA hydrolase
C7S18_00880	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
C7S18_00885	COG3118	belongs to the thioredoxin family
C7S18_00905	COG5002	protein histidine kinase activity
C7S18_00905	COG2205	protein histidine kinase activity
C7S18_00905	COG0784	Response regulator, receiver
C7S18_00910	COG3706	GGDEF domain
C7S18_00955	COG0725	ABC transporter, periplasmic molybdate-binding protein
C7S18_00960	COG4149	molybdate abc transporter
C7S18_01015	COG0534	Mate efflux family protein
C7S18_01020	COG0616	signal peptide processing
C7S18_01030	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
C7S18_01030	COG0674	pyruvate-flavodoxin oxidoreductase activity
C7S18_01065	COG3710	Transcriptional regulator
C7S18_01130	COG3291	Pkd domain containing protein
C7S18_01145	COG0640	Transcriptional regulator
C7S18_01155	COG1309	transcriptional regulator
C7S18_01170	COG2815	serine threonine protein kinase
C7S18_01170	COG0515	serine threonine protein kinase
C7S18_01185	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C7S18_01185	COG2169	Transcriptional regulator
C7S18_01200	COG1051	belongs to the nudix hydrolase family
C7S18_01230	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
C7S18_01235	COG0138	bifunctional purine biosynthesis protein purh
C7S18_01245	COG1024	Enoyl-CoA hydratase
C7S18_01245	COG1250	3-hydroxyacyl-CoA dehydrogenase
C7S18_01250	COG0183	Belongs to the thiolase family
C7S18_01255	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C7S18_01260	COG0339	signal peptide processing
C7S18_01265	COG2001	Belongs to the MraZ family
C7S18_01270	COG0275	rRNA processing
C7S18_01275	COG3116	cell division
C7S18_01290	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
C7S18_01295	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C7S18_01310	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C7S18_01315	COG1181	Belongs to the D-alanine--D-alanine ligase family
C7S18_01335	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
C7S18_01345	COG0739	heme binding
C7S18_01350	COG0653	protein targeting
C7S18_01355	COG0352	thiamine-phosphate diphosphorylase activity
C7S18_01410	COG0457	Tetratricopeptide repeat
C7S18_01410	COG0515	serine threonine protein kinase
C7S18_01430	COG0530	calcium, potassium:sodium antiporter activity
C7S18_01450	COG1404	Belongs to the peptidase S8 family
C7S18_01475	COG1187	pseudouridine synthase activity
C7S18_01490	COG1530	ribonuclease E activity
C7S18_01495	COG0564	pseudouridine synthase activity
C7S18_01525	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
C7S18_01530	COG0626	cystathionine gamma-synthase activity
C7S18_01535	COG1522	sequence-specific DNA binding
C7S18_01545	COG0745	RESPONSE REGULATOR receiver
C7S18_01550	COG2205	protein histidine kinase activity
C7S18_01580	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C7S18_01585	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
C7S18_01605	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C7S18_01610	COG0604	alcohol dehydrogenase
C7S18_01650	COG1392	Phosphate transport regulator
C7S18_01655	COG0306	phosphate transporter
C7S18_01660	COG0590	tRNA wobble adenosine to inosine editing
C7S18_01665	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
C7S18_01670	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C7S18_01670	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C7S18_01695	COG1570	exodeoxyribonuclease VII activity
C7S18_01720	COG2207	Transcriptional regulator
C7S18_01725	COG4206	TonB-dependent receptor
C7S18_01770	COG2914	Belongs to the UPF0125 (RnfH) family
C7S18_01775	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C7S18_01805	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C7S18_01810	COG0497	DNA recombination
C7S18_01815	COG1596	polysaccharide export
C7S18_01815	COG1555	photosystem II stabilization
C7S18_01835	COG0678	peroxiredoxin activity
C7S18_01835	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
C7S18_01840	COG1028	Short-chain dehydrogenase reductase Sdr
C7S18_01845	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
C7S18_01855	COG0405	Gamma-glutamyltransferase
C7S18_01860	COG1028	Short-chain dehydrogenase reductase Sdr
C7S18_01880	COG1760	l-serine dehydratase
C7S18_01895	COG0267	Belongs to the bacterial ribosomal protein bL33 family
C7S18_01900	COG0227	Belongs to the bacterial ribosomal protein bL28 family
C7S18_01910	COG2086	electron transfer activity
C7S18_01925	COG3118	belongs to the thioredoxin family
C7S18_01955	COG0730	response to heat
C7S18_01990	COG0754	glutathionylspermidine amidase activity
C7S18_01995	COG0069	glutamate synthase activity
C7S18_02015	COG1960	acyl-CoA dehydrogenase activity
C7S18_02025	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
C7S18_02035	COG1960	acyl-CoA dehydrogenase activity
C7S18_02055	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
C7S18_02060	COG0575	Belongs to the CDS family
C7S18_02065	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
C7S18_02070	COG0750	zinc metalloprotease
C7S18_02075	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C7S18_02085	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C7S18_02095	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C7S18_02130	COG1278	Cold shock
C7S18_02140	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C7S18_02165	COG4977	sequence-specific DNA binding
C7S18_02170	COG3012	SEC-C Motif Domain Protein
C7S18_02230	COG2815	serine threonine protein kinase
C7S18_02230	COG0515	serine threonine protein kinase
C7S18_02240	COG0800	Aldolase
C7S18_02245	COG0837	glucose binding
C7S18_02260	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
C7S18_02315	COG3706	GGDEF domain
C7S18_02325	COG0596	Alpha beta hydrolase
C7S18_02330	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
C7S18_02340	COG5265	(ABC) transporter
C7S18_02355	COG0717	Belongs to the dCTP deaminase family
C7S18_02360	COG0489	protein tyrosine kinase activity
C7S18_02370	COG4771	TonB-dependent receptor
C7S18_02375	COG0457	Tetratricopeptide repeat
C7S18_02380	COG5001	Diguanylate cyclase
C7S18_02380	COG3300	MHYT domain
C7S18_02395	COG1446	asparaginase
C7S18_02415	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C7S18_02420	COG0305	Participates in initiation and elongation during chromosome replication
C7S18_02445	COG3046	protein related to deoxyribodipyrimidine photolyase
C7S18_02450	COG1028	Short-chain dehydrogenase reductase Sdr
C7S18_02470	COG1136	(ABC) transporter
C7S18_02475	COG4591	ABC-type transport system involved in lipoprotein release permease component
C7S18_02480	COG2986	histidine ammonia-lyase
C7S18_02520	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C7S18_02525	COG4650	regulator
C7S18_02535	COG1690	Belongs to the RtcB family
C7S18_02550	COG0384	phenazine biosynthesis protein PhzF
C7S18_02570	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C7S18_02580	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
C7S18_02645	COG0181	hydroxymethylbilane synthase activity
C7S18_02650	COG3158	transport of potassium into the cell
C7S18_02655	COG2255	four-way junction helicase activity
C7S18_02695	COG1966	Carbon starvation protein
C7S18_02705	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C7S18_02710	COG1611	Belongs to the LOG family
C7S18_02715	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
C7S18_02725	COG1902	pentaerythritol trinitrate reductase activity
C7S18_02725	COG0446	pyridine nucleotide-disulphide oxidoreductase
C7S18_02745	COG0384	phenazine biosynthesis protein PhzF
C7S18_02755	COG0336	Belongs to the RNA methyltransferase TrmD family
C7S18_02765	COG0228	four-way junction DNA binding
C7S18_02770	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
C7S18_02775	COG4137	Cytochrome C assembly protein
C7S18_02790	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
C7S18_02805	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
C7S18_02820	COG0492	ferredoxin-NADP+ reductase activity
C7S18_02825	COG1674	ftsk spoiiie
C7S18_02830	COG1024	Enoyl-CoA hydratase
C7S18_02850	COG0515	serine threonine protein kinase
C7S18_02885	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
C7S18_02915	COG5001	Diguanylate cyclase
C7S18_02945	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
C7S18_03005	COG0210	DNA helicase
C7S18_03010	COG1228	amidohydrolase
C7S18_03020	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C7S18_03025	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C7S18_03040	COG1309	transcriptional regulator
C7S18_03050	COG3100	YcgL domain-containing protein
C7S18_03065	COG0018	arginyl-trna synthetase
C7S18_03070	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
C7S18_03075	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
C7S18_03115	COG1388	LysM domain
C7S18_03115	COG0741	lytic transglycosylase activity
C7S18_03120	COG0456	acetyltransferase
C7S18_03155	COG1846	Transcriptional regulator
C7S18_03200	COG0254	rRNA binding
C7S18_03205	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
C7S18_03210	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
C7S18_03240	COG4266	Belongs to the allantoicase family
C7S18_03245	COG1137	ATPase activity
C7S18_03260	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
C7S18_03270	COG0271	Belongs to the BolA IbaG family
C7S18_03275	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
C7S18_03290	COG0789	Transcriptional regulator
C7S18_03315	COG0402	S-adenosylhomocysteine deaminase activity
C7S18_03365	COG0493	'glutamate synthase
C7S18_03385	COG1953	Uracil, thiamine, allantoin
C7S18_03400	COG0784	Response regulator, receiver
C7S18_03400	COG2198	Histidine kinase
C7S18_03400	COG5002	protein histidine kinase activity
C7S18_03425	COG2304	oxidoreductase activity
C7S18_03430	COG4152	abc transporter atp-binding protein
C7S18_03435	COG1668	transmembrane transport
C7S18_03450	COG0552	protein localization to endoplasmic reticulum
C7S18_03455	COG0742	ribosomal rna small subunit methyltransferase
C7S18_03460	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
C7S18_03470	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
C7S18_03530	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
C7S18_03545	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
C7S18_03550	COG3706	GGDEF domain
C7S18_03560	COG2194	sulfuric ester hydrolase activity
C7S18_03570	COG2197	response regulator
C7S18_03590	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C7S18_03595	COG0328	RNA-DNA hybrid ribonuclease activity
C7S18_03605	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C7S18_03650	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C7S18_03650	COG0519	Catalyzes the synthesis of GMP from XMP
C7S18_03655	COG1733	regulation of RNA biosynthetic process
C7S18_03675	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
C7S18_03680	COG1127	ABC transporter
C7S18_03695	COG1846	Transcriptional regulator
C7S18_03695	COG0456	acetyltransferase
C7S18_03715	COG1322	Protein conserved in bacteria
C7S18_03720	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C7S18_03770	COG2239	Acts as a magnesium transporter
C7S18_03780	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
C7S18_03840	COG1506	peptidase
C7S18_03840	COG0823	Involved in the tonB-independent uptake of proteins
C7S18_03845	COG0762	integral membrane protein
C7S18_03855	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
C7S18_03870	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C7S18_03885	COG0538	isocitrate dehydrogenase activity
C7S18_03890	COG1183	phosphatidylcholine synthase activity
C7S18_03910	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
C7S18_03915	COG1127	ABC transporter
C7S18_03930	COG5001	Diguanylate cyclase
C7S18_03930	COG5002	protein histidine kinase activity
C7S18_03945	COG0456	acetyltransferase
C7S18_03960	COG4566	intracellular signal transduction
C7S18_03985	COG1136	(ABC) transporter
C7S18_03995	COG3275	phosphorelay sensor kinase activity
C7S18_04000	COG3279	Response regulator of the LytR AlgR family
C7S18_04005	COG0583	DNA-binding transcription factor activity
C7S18_04080	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
C7S18_04095	COG4946	Tricorn protease homolog
C7S18_04095	COG0793	Belongs to the peptidase S41A family
C7S18_04105	COG2356	endonuclease I
C7S18_04130	COG0542	response to heat
C7S18_04145	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
C7S18_04150	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
C7S18_04155	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
C7S18_04165	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C7S18_04200	COG0358	DNA primase activity
C7S18_04215	COG0582	viral genome integration into host DNA
C7S18_04230	COG3273	potassium ion transport
C7S18_04230	COG0471	metal ion transport
C7S18_04245	COG4206	TonB-dependent receptor
C7S18_04250	COG2226	methyltransferase
C7S18_04265	COG1012	belongs to the aldehyde dehydrogenase family
C7S18_04270	COG1177	transmembrane transport
C7S18_04275	COG1176	ABC-type spermidine putrescine transport system, permease component I
C7S18_04280	COG3842	ATPase activity
C7S18_04300	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
C7S18_04305	COG0174	glutamine synthetase
C7S18_04310	COG0494	nUDIX hydrolase
C7S18_04315	COG1218	3'(2'),5'-bisphosphate nucleotidase
C7S18_04320	COG3956	TIGRFAM MazG family protein
C7S18_04325	COG2815	serine threonine protein kinase
C7S18_04325	COG0515	serine threonine protein kinase
C7S18_04335	COG0515	serine threonine protein kinase
C7S18_04335	COG2815	serine threonine protein kinase
C7S18_04340	COG2815	serine threonine protein kinase
C7S18_04340	COG0515	serine threonine protein kinase
C7S18_04350	COG0515	serine threonine protein kinase
C7S18_04370	COG3706	GGDEF domain
C7S18_04370	COG5001	Diguanylate cyclase
C7S18_04370	COG2203	Gaf domain
C7S18_04370	COG4251	negative regulation of phosphorylation
C7S18_04375	COG0426	domain, Protein
C7S18_04375	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C7S18_04395	COG1703	isobutyryl-CoA mutase activity
C7S18_04395	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
C7S18_04395	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
C7S18_04430	COG0494	nUDIX hydrolase
C7S18_04460	COG3039	Transposase
C7S18_04515	COG3039	Transposase
C7S18_04610	COG0515	serine threonine protein kinase
C7S18_04610	COG2815	serine threonine protein kinase
C7S18_04620	COG1404	Belongs to the peptidase S8 family
C7S18_04660	COG0243	molybdopterin cofactor binding
C7S18_04720	COG0515	serine threonine protein kinase
C7S18_04720	COG2815	serine threonine protein kinase
C7S18_04755	COG0515	serine threonine protein kinase
C7S18_04755	COG2815	serine threonine protein kinase
C7S18_04805	COG0735	belongs to the Fur family
C7S18_04825	COG3852	Histidine kinase
C7S18_04840	COG3104	oligopeptide transport
C7S18_04885	COG2815	serine threonine protein kinase
C7S18_04885	COG0515	serine threonine protein kinase
C7S18_04895	COG2815	serine threonine protein kinase
C7S18_04895	COG0515	serine threonine protein kinase
C7S18_04925	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
C7S18_04935	COG3706	GGDEF domain
C7S18_04935	COG0745	RESPONSE REGULATOR receiver
C7S18_04945	COG1199	ATP-dependent helicase activity
C7S18_04955	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C7S18_04960	COG0823	Involved in the tonB-independent uptake of proteins
C7S18_04960	COG1506	peptidase
C7S18_04970	COG2350	Protein conserved in bacteria
C7S18_04980	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
C7S18_04985	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
C7S18_04990	COG1187	pseudouridine synthase activity
C7S18_04995	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
C7S18_05000	COG2967	ApaG domain
C7S18_05015	COG1611	Belongs to the LOG family
C7S18_05020	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
C7S18_05030	COG1994	Peptidase M50
C7S18_05050	COG0515	serine threonine protein kinase
C7S18_05050	COG2815	serine threonine protein kinase
C7S18_05075	COG0348	domain, Protein
C7S18_05100	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
C7S18_05110	COG0460	homoserine dehydrogenase
C7S18_05110	COG0527	aspartate kinase activity
C7S18_05115	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
C7S18_05125	COG0776	regulation of translation
C7S18_05135	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
C7S18_05155	COG1228	amidohydrolase
C7S18_05205	COG0386	Belongs to the glutathione peroxidase family
C7S18_05210	COG0295	cytidine deaminase activity
C7S18_05215	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
C7S18_05220	COG1404	Belongs to the peptidase S8 family
C7S18_05220	COG4412	M6 family metalloprotease domain protein
C7S18_05235	COG2133	pyrroloquinoline quinone binding
C7S18_05250	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C7S18_05255	COG0741	lytic transglycosylase activity
C7S18_05310	COG0483	inositol monophosphate 1-phosphatase activity
C7S18_05320	COG1505	serine-type exopeptidase activity
C7S18_05325	COG0741	lytic transglycosylase activity
C7S18_05355	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
C7S18_05365	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C7S18_05370	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
C7S18_05375	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C7S18_05380	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
C7S18_05425	COG4206	TonB-dependent receptor
C7S18_05505	COG2828	Protein conserved in bacteria
C7S18_05535	COG0811	peptide transport
C7S18_05540	COG0848	biopolymer transport protein
C7S18_05545	COG1132	(ABC) transporter
C7S18_05550	COG1663	tetraacyldisaccharide 4'-kinase activity
C7S18_05560	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C7S18_05570	COG0322	excinuclease ABC activity
C7S18_05595	COG0582	viral genome integration into host DNA
C7S18_05640	COG1956	GAF domain-containing protein
C7S18_05655	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C7S18_05665	COG1686	Belongs to the peptidase S11 family
C7S18_05675	COG2951	lytic endotransglycosylase activity
C7S18_05680	COG0697	spore germination
C7S18_05690	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
C7S18_05700	COG3647	Membrane
C7S18_05740	COG0582	viral genome integration into host DNA
C7S18_05755	COG0515	serine threonine protein kinase
C7S18_05760	COG0142	geranyltranstransferase activity
C7S18_05770	COG0629	single-stranded DNA binding
C7S18_05815	COG1228	amidohydrolase
C7S18_05825	COG3118	belongs to the thioredoxin family
C7S18_05855	COG1399	metal-binding, possibly nucleic acid-binding protein
C7S18_05860	COG0333	Belongs to the bacterial ribosomal protein bL32 family
C7S18_05865	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C7S18_05875	COG1028	Short-chain dehydrogenase reductase Sdr
C7S18_05895	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
C7S18_05900	COG4181	ATPase activity
C7S18_05915	COG1473	amidohydrolase
C7S18_05920	COG1834	amidinotransferase
C7S18_05955	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
C7S18_05960	COG0137	argininosuccinate synthase activity
C7S18_05965	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C7S18_05970	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
C7S18_05975	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
C7S18_05980	COG0165	Argininosuccinate lyase
C7S18_05985	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
C7S18_06025	COG3039	Transposase
C7S18_06330	COG1473	amidohydrolase
C7S18_06350	COG3039	Transposase
C7S18_06360	COG2319	Wd-40 repeat
C7S18_06360	COG4249	Peptidase C14 caspase catalytic subunit p20
C7S18_06455	COG3243	poly(R)-hydroxyalkanoic acid synthase
C7S18_06460	COG0076	glutamate decarboxylase activity
C7S18_06475	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
C7S18_06485	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C7S18_06495	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
C7S18_06510	COG0617	tRNA 3'-terminal CCA addition
C7S18_06515	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
C7S18_06520	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
C7S18_06525	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
C7S18_06535	COG0167	dihydroorotate dehydrogenase activity
C7S18_06545	COG1012	belongs to the aldehyde dehydrogenase family
C7S18_06550	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
C7S18_06565	COG0433	COG0433 Predicted ATPase
C7S18_06570	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C7S18_06585	COG1136	(ABC) transporter
C7S18_06585	COG0577	efflux transmembrane transporter activity
C7S18_06595	COG1960	acyl-CoA dehydrogenase activity
C7S18_06615	COG1012	belongs to the aldehyde dehydrogenase family
C7S18_06620	COG3284	Transcriptional regulator
C7S18_06670	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
C7S18_06675	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C7S18_06680	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
C7S18_06685	COG0066	3-isopropylmalate dehydratase activity
C7S18_06700	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
C7S18_06705	COG0134	indole-3-glycerol-phosphate synthase activity
C7S18_06715	COG1294	oxidase, subunit
C7S18_06720	COG1271	oxidase subunit
C7S18_06740	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
C7S18_06745	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C7S18_06760	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
C7S18_06770	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
C7S18_06770	COG0140	phosphoribosyl-ATP diphosphatase activity
C7S18_06775	COG0823	Involved in the tonB-independent uptake of proteins
C7S18_06775	COG1506	peptidase
C7S18_06800	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
C7S18_06810	COG0076	glutamate decarboxylase activity
C7S18_06815	COG0285	dihydrofolate synthase activity
C7S18_06820	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
C7S18_06825	COG0159	tryptophan synthase activity
C7S18_06830	COG0133	tryptophan synthase activity
C7S18_06835	COG0418	dihydroorotase activity
C7S18_06875	COG1132	(ABC) transporter
C7S18_06895	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
C7S18_06900	COG1238	metal cluster binding
C7S18_06905	COG4942	peptidase
C7S18_06905	COG1388	LysM domain
C7S18_06920	COG1131	(ABC) transporter
C7S18_06930	COG3161	chorismate lyase activity
C7S18_06950	COG4221	oxidoreductase activity
C7S18_06960	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C7S18_06975	COG1012	belongs to the aldehyde dehydrogenase family
C7S18_06990	COG2815	serine threonine protein kinase
C7S18_06990	COG0515	serine threonine protein kinase
C7S18_07000	COG2815	serine threonine protein kinase
C7S18_07000	COG0515	serine threonine protein kinase
C7S18_07005	COG1595	DNA-templated transcription, initiation
C7S18_07025	COG0534	Mate efflux family protein
C7S18_07030	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C7S18_07035	COG4232	protein-disulfide reductase activity
C7S18_07050	COG2373	Large extracellular alpha-helical protein
C7S18_07055	COG4953	penicillin-binding protein 1C
C7S18_07065	COG0596	Alpha beta hydrolase
C7S18_07070	COG0642	Histidine kinase
C7S18_07090	COG0488	(ABC) transporter
C7S18_07095	COG3706	GGDEF domain
C7S18_07125	COG4589	Belongs to the CDS family
C7S18_07140	COG0671	phosphoesterase, PA-phosphatase related
C7S18_07140	COG2453	phosphatase
C7S18_07145	COG2267	carboxylic ester hydrolase activity
C7S18_07150	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
C7S18_07160	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
C7S18_07190	COG1574	metal-dependent hydrolase with the TIM-barrel fold
C7S18_07205	COG0415	Belongs to the DNA photolyase family
C7S18_07220	COG2119	membrane
C7S18_07230	COG1902	pentaerythritol trinitrate reductase activity
C7S18_07230	COG0446	pyridine nucleotide-disulphide oxidoreductase
C7S18_07245	COG1505	serine-type exopeptidase activity
C7S18_07250	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C7S18_07260	COG4774	siderophore transport
C7S18_07270	COG3128	pkhd-type hydroxylase
C7S18_07280	COG0531	amino acid
C7S18_07295	COG0354	folic acid binding
C7S18_07305	COG2009	succinate dehydrogenase
C7S18_07310	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
C7S18_07315	COG1053	succinate dehydrogenase
C7S18_07355	COG2819	hydrolase of the alpha beta superfamily
C7S18_07360	COG1192	Involved in chromosome partitioning
C7S18_07365	COG1475	DNA binding
C7S18_07375	COG4067	protein conserved in archaea
C7S18_07375	COG0189	ligase activity
C7S18_07390	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
C7S18_07395	COG0443	Heat shock 70 kDa protein
C7S18_07410	COG0456	acetyltransferase
C7S18_07410	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
C7S18_07425	COG0583	DNA-binding transcription factor activity
C7S18_07440	COG0243	molybdopterin cofactor binding
C7S18_07455	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
C7S18_07460	COG2850	peptidyl-arginine hydroxylation
C7S18_07495	COG1385	rRNA (uridine-N3-)-methyltransferase activity
C7S18_07515	COG0004	ammonium transporteR
C7S18_07530	COG2354	Protein conserved in bacteria
C7S18_07540	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
C7S18_07555	COG1592	Rubrerythrin
C7S18_07565	COG1585	Membrane protein implicated in regulation of membrane protease activity
C7S18_07570	COG0330	HflC and HflK could
C7S18_07595	COG1560	Kdo2-lipid A biosynthetic process
C7S18_07600	COG1519	Transferase
C7S18_07620	COG0424	maF-like protein
C7S18_07640	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C7S18_07645	COG1138	Cytochrome C-type biogenesis protein
C7S18_07675	COG1404	Belongs to the peptidase S8 family
C7S18_07680	COG0527	aspartate kinase activity
C7S18_07690	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
C7S18_07695	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
C7S18_07705	COG1047	Peptidyl-prolyl cis-trans
C7S18_07720	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
C7S18_07725	COG0312	modulator of DNA gyrase
C7S18_07770	COG0745	RESPONSE REGULATOR receiver
C7S18_07775	COG0642	Histidine kinase
C7S18_07800	COG0156	8-amino-7-oxononanoate synthase activity
C7S18_07805	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
C7S18_07825	COG0084	hydrolase, TatD family'
C7S18_07840	COG0584	glycerophosphoryl diester phosphodiesterase
C7S18_07845	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
C7S18_07875	COG4771	TonB-dependent receptor
C7S18_07915	COG2197	response regulator
C7S18_07925	COG3039	Transposase
C7S18_07930	COG2186	Transcriptional regulator
C7S18_07935	COG1131	(ABC) transporter
C7S18_07965	COG1136	(ABC) transporter
C7S18_07995	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C7S18_08010	COG2124	cytochrome p450
C7S18_08015	COG0318	PFAM AMP-dependent synthetase and ligase
C7S18_08035	COG1131	(ABC) transporter
C7S18_08050	COG1136	(ABC) transporter
C7S18_08060	COG0577	efflux transmembrane transporter activity
C7S18_08080	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
C7S18_08140	COG0640	Transcriptional regulator
C7S18_08160	COG1404	Belongs to the peptidase S8 family
C7S18_08195	COG1511	domain protein
C7S18_08195	COG3264	Mechanosensitive ion channel
C7S18_08200	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C7S18_08205	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C7S18_08250	COG3275	phosphorelay sensor kinase activity
C7S18_08255	COG3279	Response regulator of the LytR AlgR family
C7S18_08285	COG0642	Histidine kinase
C7S18_08300	COG1196	nuclear chromosome segregation
C7S18_08370	COG5002	protein histidine kinase activity
C7S18_08460	COG1028	Short-chain dehydrogenase reductase Sdr
C7S18_08485	COG4772	TonB-dependent receptor
C7S18_08515	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C7S18_08575	COG0672	)-iron permease
C7S18_08730	COG1022	Amp-dependent synthetase and ligase
C7S18_08740	COG1028	Short-chain dehydrogenase reductase Sdr
C7S18_08750	COG3279	Response regulator of the LytR AlgR family
C7S18_08755	COG3275	phosphorelay sensor kinase activity
C7S18_08775	COG3220	belongs to the UPF0276 family
C7S18_08800	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
C7S18_08820	COG0753	catalase activity
C7S18_08845	COG1063	alcohol dehydrogenase
C7S18_08860	COG0745	RESPONSE REGULATOR receiver
C7S18_08865	COG2205	protein histidine kinase activity
C7S18_08895	COG1051	belongs to the nudix hydrolase family
C7S18_08895	COG1056	cytidyltransferase-related domain
C7S18_08900	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
C7S18_08930	COG1007	ATP synthesis coupled electron transport
C7S18_08945	COG0713	ATP synthesis coupled electron transport
C7S18_08955	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C7S18_08960	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
C7S18_08970	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
C7S18_08975	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
C7S18_08980	COG0649	NAD binding
C7S18_08985	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C7S18_08990	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C7S18_08995	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C7S18_09005	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
C7S18_09010	COG0149	triose-phosphate isomerase activity
C7S18_09015	COG0300	oxidoreductase activity
C7S18_09025	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C7S18_09045	COG1012	belongs to the aldehyde dehydrogenase family
C7S18_09050	COG1396	sequence-specific DNA binding
C7S18_09050	COG1917	Cupin 2, conserved barrel domain protein
C7S18_09060	COG0686	Belongs to the AlaDH PNT family
C7S18_09065	COG0010	Belongs to the arginase family
C7S18_09090	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
C7S18_09095	COG0861	Integral membrane protein TerC family
C7S18_09110	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
C7S18_09110	COG0316	Belongs to the HesB IscA family
C7S18_09115	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C7S18_09125	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
C7S18_09145	COG4535	Mg2 and Co2 transporter CorC
C7S18_09150	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
C7S18_09160	COG1702	phosphate starvation-inducible protein PhoH
C7S18_09170	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C7S18_09180	COG0583	DNA-binding transcription factor activity
C7S18_09195	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C7S18_09200	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C7S18_09205	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
C7S18_09215	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C7S18_09240	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
C7S18_09245	COG2813	Specifically methylates the guanine in position
C7S18_09260	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C7S18_09265	COG0557	exoribonuclease II activity
C7S18_09275	COG0515	serine threonine protein kinase
C7S18_09275	COG2815	serine threonine protein kinase
C7S18_09280	COG1546	Belongs to the CinA family
C7S18_09285	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
C7S18_09300	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
C7S18_09310	COG2197	response regulator
C7S18_09315	COG4585	Histidine kinase
C7S18_09320	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C7S18_09330	COG0515	serine threonine protein kinase
C7S18_09330	COG2815	serine threonine protein kinase
C7S18_09345	COG0746	molybdenum cofactor guanylyltransferase activity
C7S18_09350	COG0303	'Molybdopterin
C7S18_09355	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
C7S18_09460	COG2433	Pfam Transposase IS66
C7S18_09540	COG0585	pseudouridine synthase activity
C7S18_09650	COG1309	transcriptional regulator
C7S18_09665	COG0640	Transcriptional regulator
C7S18_09690	COG2272	Belongs to the type-B carboxylesterase lipase family
C7S18_09810	COG3739	integral membrane protein
C7S18_09840	COG5002	protein histidine kinase activity
C7S18_09840	COG2198	Histidine kinase
C7S18_09840	COG0784	Response regulator, receiver
C7S18_09865	COG3360	Dodecin
C7S18_09875	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
C7S18_09880	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
C7S18_09895	COG1216	Glycosyl transferase, family 2
C7S18_09895	COG0438	transferase activity, transferring glycosyl groups
C7S18_09940	COG4585	Histidine kinase
C7S18_09945	COG2197	response regulator
C7S18_09955	COG4206	TonB-dependent receptor
C7S18_09960	COG0257	Belongs to the bacterial ribosomal protein bL36 family
C7S18_09965	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
C7S18_09970	COG0505	Belongs to the CarA family
C7S18_09990	COG1012	belongs to the aldehyde dehydrogenase family
C7S18_10000	COG0531	amino acid
C7S18_10015	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
C7S18_10020	COG2877	3-deoxy-8-phosphooctulonate synthase activity
C7S18_10025	COG0504	CTP synthase activity
C7S18_10030	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C7S18_10035	COG1393	Belongs to the ArsC family
C7S18_10040	COG2171	N-acyltransferase activity
C7S18_10060	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
C7S18_10080	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
C7S18_10090	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
C7S18_10100	COG0193	aminoacyl-tRNA hydrolase activity
C7S18_10105	COG0012	GTP binding
C7S18_10120	COG3039	Transposase
C7S18_10130	COG0338	D12 class N6 adenine-specific DNA methyltransferase
C7S18_10205	COG3039	Transposase
C7S18_10315	COG3039	Transposase
C7S18_10360	COG1404	Belongs to the peptidase S8 family
C7S18_10375	COG0457	Tetratricopeptide repeat
C7S18_10395	COG1901	pseudouridine methyltransferase
C7S18_10440	COG0577	efflux transmembrane transporter activity
C7S18_10445	COG1136	(ABC) transporter
C7S18_10450	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C7S18_10525	COG0753	catalase activity
C7S18_10570	COG0671	phosphoesterase, PA-phosphatase related
C7S18_10575	COG0438	transferase activity, transferring glycosyl groups
C7S18_10585	COG0659	secondary active sulfate transmembrane transporter activity
C7S18_10610	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
C7S18_10620	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
C7S18_10625	COG2251	uridine kinase activity
C7S18_10625	COG0195	Participates in both transcription termination and antitermination
C7S18_10630	COG0779	Required for maturation of 30S ribosomal subunits
C7S18_10655	COG0039	L-malate dehydrogenase activity
C7S18_10695	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
C7S18_10705	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
C7S18_10710	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
C7S18_10715	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C7S18_10720	COG2207	Transcriptional regulator
C7S18_10720	COG1917	Cupin 2, conserved barrel domain protein
C7S18_10735	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C7S18_10745	COG3706	GGDEF domain
C7S18_10750	COG0542	response to heat
C7S18_10755	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
C7S18_10770	COG2915	High frequency lysogenization protein hflD homolog
C7S18_10780	COG0180	Tryptophanyl-tRNA synthetase
C7S18_10795	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C7S18_10820	COG0745	RESPONSE REGULATOR receiver
C7S18_10825	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
C7S18_10840	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C7S18_10860	COG2878	Part of a membrane complex involved in electron transport
C7S18_10865	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C7S18_10865	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C7S18_10870	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
C7S18_10875	COG0802	atpase or kinase
C7S18_10880	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
C7S18_10880	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
C7S18_10895	COG0745	RESPONSE REGULATOR receiver
C7S18_10895	COG3706	GGDEF domain
C7S18_10905	COG0515	serine threonine protein kinase
C7S18_10905	COG2815	serine threonine protein kinase
C7S18_10945	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
C7S18_10955	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
C7S18_10975	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
C7S18_10980	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
C7S18_10985	COG2205	protein histidine kinase activity
C7S18_10990	COG0006	proline dipeptidase activity
C7S18_11020	COG0577	efflux transmembrane transporter activity
C7S18_11020	COG1136	(ABC) transporter
C7S18_11025	COG0577	efflux transmembrane transporter activity
C7S18_11025	COG1136	(ABC) transporter
C7S18_11065	COG0408	coproporphyrinogen oxidase activity
C7S18_11070	COG1968	undecaprenyl-diphosphatase activity
C7S18_11080	COG0493	'glutamate synthase
C7S18_11085	COG0070	glutamate synthase
C7S18_11085	COG0069	glutamate synthase activity
C7S18_11085	COG0067	glutamate synthase
C7S18_11090	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C7S18_11110	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
C7S18_11115	COG0024	Methionine aminopeptidase
C7S18_11130	COG0436	Aminotransferase
C7S18_11140	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C7S18_11160	COG0739	heme binding
C7S18_11165	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
C7S18_11175	COG1643	Atp-dependent helicase
C7S18_11205	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
C7S18_11205	COG2070	2-Nitropropane dioxygenase
C7S18_11250	COG4771	TonB-dependent receptor
C7S18_11270	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C7S18_11295	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C7S18_11355	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C7S18_11385	COG0443	Heat shock 70 kDa protein
C7S18_11425	COG0564	pseudouridine synthase activity
C7S18_11445	COG2304	oxidoreductase activity
C7S18_11450	COG2818	Glycosylase
C7S18_11465	COG0028	Belongs to the TPP enzyme family
C7S18_11470	COG1304	FMN binding
C7S18_11485	COG0473	3-isopropylmalate dehydrogenase activity
C7S18_11495	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
C7S18_11500	COG2920	part of a sulfur-relay system
C7S18_11515	COG4783	chaperone-mediated protein folding
C7S18_11520	COG0745	RESPONSE REGULATOR receiver
C7S18_11540	COG4948	Mandelate Racemase Muconate Lactonizing
C7S18_11550	COG1301	dicarboxylic acid transport
C7S18_11560	COG1530	ribonuclease E activity
C7S18_11565	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C7S18_11575	COG1278	Cold shock
C7S18_11595	COG1381	Involved in DNA repair and RecF pathway recombination
C7S18_11600	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
C7S18_11615	COG0681	Belongs to the peptidase S26 family
C7S18_11625	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C7S18_11655	COG1024	Enoyl-CoA hydratase
C7S18_11655	COG1250	3-hydroxyacyl-CoA dehydrogenase
C7S18_11660	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C7S18_11700	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
C7S18_11705	COG4104	PAAR repeat-containing protein
C7S18_11715	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
C7S18_11740	COG1960	acyl-CoA dehydrogenase activity
C7S18_11750	COG0529	Catalyzes the synthesis of activated sulfate
C7S18_11750	COG2046	Belongs to the sulfate adenylyltransferase family
C7S18_11760	COG3437	response regulator, receiver
C7S18_11760	COG0784	Response regulator, receiver
C7S18_11765	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C7S18_11765	COG4191	Histidine kinase
C7S18_11780	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C7S18_11805	COG0243	molybdopterin cofactor binding
C7S18_11835	COG1309	transcriptional regulator
C7S18_11840	COG4651	solute:proton antiporter activity
C7S18_11840	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
C7S18_11880	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
C7S18_11950	COG2205	protein histidine kinase activity
C7S18_11960	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
C7S18_11965	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
C7S18_11975	COG2226	methyltransferase
C7S18_12035	COG0714	Associated with various cellular activities
C7S18_12075	COG0515	serine threonine protein kinase
C7S18_12075	COG2815	serine threonine protein kinase
C7S18_12085	COG0252	asparaginase activity
C7S18_12095	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C7S18_12100	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C7S18_12330	COG2801	Transposase and inactivated derivatives
C7S18_12370	COG1404	Belongs to the peptidase S8 family
C7S18_12405	COG1404	Belongs to the peptidase S8 family
C7S18_12420	COG0640	Transcriptional regulator
C7S18_12425	COG0446	pyridine nucleotide-disulphide oxidoreductase
C7S18_12475	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
C7S18_12480	COG1466	dna polymerase III delta subunit
C7S18_12490	COG0495	leucyl-tRNA aminoacylation
C7S18_12500	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
C7S18_12505	COG1288	antiporter activity
C7S18_12520	COG2205	protein histidine kinase activity
C7S18_12525	COG0745	RESPONSE REGULATOR receiver
C7S18_12550	COG0351	phosphomethylpyrimidine kinase
C7S18_12555	COG3844	kynureninase activity
C7S18_12565	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C7S18_12575	COG2135	peptidase activity
C7S18_12590	COG1605	Chorismate mutase
C7S18_12590	COG0077	Prephenate dehydratase
C7S18_12595	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C7S18_12600	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
C7S18_12605	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C7S18_12610	COG0415	Belongs to the DNA photolyase family
C7S18_12630	COG2197	response regulator
C7S18_12650	COG0129	dihydroxy-acid dehydratase activity
C7S18_12670	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C7S18_12675	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C7S18_12690	COG0704	Plays a role in the regulation of phosphate uptake
C7S18_12705	COG0573	inorganic phosphate transmembrane transporter activity
C7S18_12710	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
C7S18_12725	COG1923	regulation of RNA biosynthetic process
C7S18_12730	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
C7S18_12735	COG0330	HflC and HflK could
C7S18_12740	COG0330	HflC and HflK could
C7S18_12750	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
C7S18_12780	COG0556	nucleotide-excision repair
C7S18_12805	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
C7S18_12810	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C7S18_12815	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C7S18_12825	COG2096	Adenosyltransferase
C7S18_12830	COG0123	including yeast histone deacetylase and acetoin utilization protein
C7S18_12840	COG1960	acyl-CoA dehydrogenase activity
C7S18_12855	COG3047	cAMP biosynthetic process
C7S18_12860	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
C7S18_12870	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
C7S18_12885	COG1028	Short-chain dehydrogenase reductase Sdr
C7S18_12895	COG0515	serine threonine protein kinase
C7S18_12910	COG0697	spore germination
C7S18_12920	COG1301	dicarboxylic acid transport
C7S18_12925	COG3540	Alkaline phosphatase
C7S18_12975	COG2259	Doxx family
C7S18_12990	COG4953	penicillin-binding protein 1C
C7S18_12995	COG1538	Outer membrane efflux protein
C7S18_13000	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
C7S18_13010	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C7S18_13015	COG1309	transcriptional regulator
C7S18_13025	COG1758	RNA polymerase activity
C7S18_13045	COG2755	lipolytic protein G-D-S-L family
C7S18_13045	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
C7S18_13080	COG0714	Associated with various cellular activities
C7S18_13120	COG2154	pterin-4-alpha-carbinolamine dehydratase
C7S18_13125	COG0799	negative regulation of ribosome biogenesis
C7S18_13130	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
C7S18_13135	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
C7S18_13145	COG1469	GTP cyclohydrolase I activity
C7S18_13160	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C7S18_13165	COG0402	S-adenosylhomocysteine deaminase activity
C7S18_13170	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
C7S18_13175	COG1509	lysine 2,3-aminomutase activity
C7S18_13180	COG5001	Diguanylate cyclase
C7S18_13185	COG1082	Xylose isomerase domain protein TIM barrel
C7S18_13225	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
C7S18_13250	COG0697	spore germination
C7S18_13260	COG0501	Belongs to the peptidase M48B family
C7S18_13270	COG1028	Short-chain dehydrogenase reductase Sdr
C7S18_13285	COG1028	Short-chain dehydrogenase reductase Sdr
C7S18_13315	COG4191	Histidine kinase
C7S18_13315	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C7S18_13320	COG2252	PERMEase
C7S18_13340	COG0776	regulation of translation
C7S18_13350	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
C7S18_13360	COG0291	Belongs to the bacterial ribosomal protein bL35 family
C7S18_13365	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
C7S18_13370	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
C7S18_13410	COG2226	methyltransferase
C7S18_13410	COG0596	Alpha beta hydrolase
C7S18_13410	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C7S18_13430	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C7S18_13435	COG0154	amidase activity
C7S18_13440	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C7S18_13445	COG1077	Cell shape determining protein MreB Mrl
C7S18_13450	COG1792	Involved in formation and maintenance of cell shape
C7S18_13460	COG0768	penicillin binding
C7S18_13465	COG0772	Belongs to the SEDS family
C7S18_13470	COG1714	RDD family
C7S18_13485	COG0463	Glycosyl transferase, family 2
C7S18_13490	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
C7S18_13510	COG1286	toxin biosynthetic process
C7S18_13520	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
C7S18_13525	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
C7S18_13535	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C7S18_13540	COG0521	Mo-molybdopterin cofactor biosynthetic process
C7S18_13545	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
C7S18_13555	COG1131	(ABC) transporter
C7S18_13570	COG4771	TonB-dependent receptor
C7S18_13580	COG0358	DNA primase activity
C7S18_13605	COG0784	Response regulator, receiver
C7S18_13605	COG3437	response regulator, receiver
C7S18_13645	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C7S18_13655	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
C7S18_13660	COG0235	Class ii aldolase
C7S18_13675	COG0105	UTP biosynthetic process
C7S18_13680	COG0820	rRNA (adenine-C2-)-methyltransferase activity
C7S18_13700	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C7S18_13705	COG1160	GTP binding
C7S18_13720	COG2815	serine threonine protein kinase
C7S18_13720	COG0515	serine threonine protein kinase
C7S18_13725	COG1073	alpha beta
C7S18_13730	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C7S18_13735	COG1420	regulation of RNA biosynthetic process
C7S18_13740	COG1404	Belongs to the peptidase S8 family
C7S18_13780	COG0625	glutathione transferase activity
C7S18_13785	COG2857	Cytochrome c1
C7S18_13790	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
C7S18_13795	COG0723	plastoquinol--plastocyanin reductase activity
C7S18_13800	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C7S18_13805	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
C7S18_13815	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
C7S18_13820	COG0261	This protein binds to 23S rRNA in the presence of protein L20
C7S18_13825	COG0211	Belongs to the bacterial ribosomal protein bL27 family
C7S18_13830	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
C7S18_13860	COG1228	amidohydrolase
C7S18_13870	COG2201	protein-glutamate methylesterase activity
C7S18_13875	COG2198	Histidine kinase
C7S18_13875	COG0643	Histidine kinase
C7S18_13885	COG0840	transmembrane signaling receptor activity
C7S18_13900	COG0189	ligase activity
C7S18_13975	COG1518	maintenance of DNA repeat elements
C7S18_13975	COG1468	defense response to virus
C7S18_14015	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
C7S18_14020	COG0009	L-threonylcarbamoyladenylate synthase
C7S18_14025	COG0859	PFAM glycosyl transferase family 9
C7S18_14060	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C7S18_14070	COG0315	cyclic pyranopterin monophosphate synthase activity
C7S18_14080	COG0314	molybdopterin synthase activity
C7S18_14090	COG1131	(ABC) transporter
C7S18_14095	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C7S18_14105	COG0386	Belongs to the glutathione peroxidase family
C7S18_14110	COG1874	Beta-galactosidase
C7S18_14110	COG0366	Alpha amylase catalytic
C7S18_14135	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C7S18_14140	COG0366	Alpha amylase catalytic
C7S18_14145	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
C7S18_14150	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
C7S18_14180	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
C7S18_14200	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
C7S18_14205	COG1028	Short-chain dehydrogenase reductase Sdr
C7S18_14210	COG2703	oxygen carrier activity
C7S18_14225	COG0492	ferredoxin-NADP+ reductase activity
C7S18_14250	COG0037	tRNA processing
C7S18_14260	COG0142	geranyltranstransferase activity
C7S18_14270	COG2815	serine threonine protein kinase
C7S18_14270	COG0515	serine threonine protein kinase
C7S18_14285	COG2270	Major facilitator Superfamily
C7S18_14315	COG0625	glutathione transferase activity
C7S18_14330	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
C7S18_14350	COG1555	photosystem II stabilization
C7S18_14360	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C7S18_14365	COG0508	dehydrogenase complex catalyzes the overall conversion of
C7S18_14375	COG2815	serine threonine protein kinase
C7S18_14375	COG0515	serine threonine protein kinase
C7S18_14380	COG0583	DNA-binding transcription factor activity
C7S18_14385	COG1064	alcohol dehydrogenase
C7S18_14395	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
C7S18_14405	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
C7S18_14425	COG3275	phosphorelay sensor kinase activity
C7S18_14435	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C7S18_14450	COG0515	serine threonine protein kinase
C7S18_14450	COG2815	serine threonine protein kinase
C7S18_14460	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
C7S18_14470	COG0513	Belongs to the DEAD box helicase family
C7S18_14475	COG1090	epimerase
C7S18_14485	COG3738	Protein conserved in bacteria
C7S18_14490	COG1216	Glycosyl transferase, family 2
C7S18_14500	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C7S18_14510	COG0745	RESPONSE REGULATOR receiver
C7S18_14510	COG3706	GGDEF domain
C7S18_14520	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C7S18_14535	COG2815	serine threonine protein kinase
C7S18_14535	COG0515	serine threonine protein kinase
C7S18_14545	COG3588	fructose-bisphosphate aldolase
C7S18_14560	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C7S18_14580	COG4771	TonB-dependent receptor
C7S18_14655	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C7S18_14670	COG2801	Transposase and inactivated derivatives
C7S18_14685	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C7S18_14750	COG1131	(ABC) transporter
C7S18_14760	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
C7S18_14780	COG0515	serine threonine protein kinase
C7S18_14780	COG2815	serine threonine protein kinase
C7S18_14790	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
C7S18_14800	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C7S18_14805	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
C7S18_14830	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C7S18_14830	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C7S18_14840	COG2900	Belongs to the SlyX family
C7S18_14855	COG0489	protein tyrosine kinase activity
C7S18_14860	COG1596	polysaccharide export
C7S18_14880	COG0688	phosphatidylethanolamine metabolic process
C7S18_14890	COG2890	protein-(glutamine-N5) methyltransferase activity
C7S18_14895	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
C7S18_14900	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
C7S18_14915	COG0135	phosphoribosylanthranilate isomerase activity
C7S18_14920	COG1253	flavin adenine dinucleotide binding
C7S18_14945	COG1534	Rna-binding protein
C7S18_14950	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
C7S18_14955	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C7S18_14965	COG0515	serine threonine protein kinase
C7S18_14965	COG2815	serine threonine protein kinase
C7S18_14990	COG0515	serine threonine protein kinase
C7S18_14990	COG2815	serine threonine protein kinase
C7S18_15030	COG1309	transcriptional regulator
C7S18_15040	COG1960	acyl-CoA dehydrogenase activity
C7S18_15050	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
C7S18_15065	COG0633	Ferredoxin
C7S18_15065	COG3217	Mosc domain protein beta barrel domain protein
C7S18_15095	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
C7S18_15100	COG0860	N-Acetylmuramoyl-L-alanine amidase
C7S18_15110	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
C7S18_15120	COG4452	Inner membrane protein CreD
C7S18_15145	COG3278	Belongs to the heme-copper respiratory oxidase family
C7S18_15150	COG1612	heme a metabolic process
C7S18_15160	COG3104	oligopeptide transport
C7S18_15230	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
C7S18_15240	COG0745	RESPONSE REGULATOR receiver
C7S18_15265	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
C7S18_15275	COG0218	Necessary for normal cell division and for the maintenance of normal septation
C7S18_15285	COG2264	protein methyltransferase activity
C7S18_15290	COG0439	Biotin carboxylase
C7S18_15295	COG0511	ligase activity, forming carbon-carbon bonds
C7S18_15300	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
C7S18_15330	COG0515	serine threonine protein kinase
C7S18_15330	COG2815	serine threonine protein kinase
C7S18_15355	COG2084	Dehydrogenase
C7S18_15385	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
C7S18_15405	COG3128	pkhd-type hydroxylase
C7S18_15500	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
C7S18_15525	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
C7S18_15530	COG2351	hydroxyisourate hydrolase activity
C7S18_15540	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
C7S18_15545	COG4191	Histidine kinase
C7S18_15545	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C7S18_15550	COG2890	protein-(glutamine-N5) methyltransferase activity
C7S18_15560	COG1187	pseudouridine synthase activity
C7S18_15575	COG0644	oxidoreductase
C7S18_15600	COG0577	efflux transmembrane transporter activity
C7S18_15600	COG1136	(ABC) transporter
C7S18_15625	COG4946	Tricorn protease homolog
C7S18_15625	COG0793	Belongs to the peptidase S41A family
C7S18_15665	COG2815	serine threonine protein kinase
C7S18_15665	COG0515	serine threonine protein kinase
C7S18_15730	COG2124	cytochrome p450
C7S18_15755	COG0515	serine threonine protein kinase
C7S18_15755	COG2815	serine threonine protein kinase
C7S18_15785	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
C7S18_15800	COG1404	Belongs to the peptidase S8 family
C7S18_15895	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
C7S18_15900	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
C7S18_15905	COG1565	acr, cog1565
C7S18_15905	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
C7S18_15925	COG0471	metal ion transport
C7S18_15935	COG2204	response regulator
C7S18_15955	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
C7S18_15965	COG1472	Belongs to the glycosyl hydrolase 3 family
C7S18_15975	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C7S18_15980	COG3209	COG3209 Rhs family protein
C7S18_16000	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
C7S18_16005	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
C7S18_16010	COG0203	ribosomal protein L17
C7S18_16015	COG0202	RNA polymerase activity
C7S18_16020	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
C7S18_16025	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
C7S18_16030	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
C7S18_16035	COG0201	protein transport
C7S18_16040	COG0200	Binds to the 23S rRNA
C7S18_16045	COG1841	ribosomal large subunit assembly
C7S18_16050	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
C7S18_16055	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
C7S18_16065	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
C7S18_16070	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
C7S18_16075	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
C7S18_16080	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
C7S18_16085	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
C7S18_16090	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
C7S18_16095	COG0255	Belongs to the universal ribosomal protein uL29 family
C7S18_16100	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
C7S18_16105	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
C7S18_16110	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
C7S18_16115	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
C7S18_16120	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
C7S18_16125	COG0089	rRNA binding
C7S18_16130	COG0088	Forms part of the polypeptide exit tunnel
C7S18_16135	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
C7S18_16145	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
C7S18_16150	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
C7S18_16160	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
C7S18_16165	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
C7S18_16170	COG0085	RNA polymerase activity
C7S18_16175	COG0222	ribosome binding
C7S18_16180	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
C7S18_16185	COG0081	regulation of translation
C7S18_16190	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
C7S18_16200	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
C7S18_16210	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
C7S18_16270	COG0346	lactoylglutathione lyase activity
C7S18_16290	COG0196	riboflavin kinase activity
C7S18_16325	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C7S18_16325	COG2190	(PTS) system
C7S18_16325	COG1263	PTS System
C7S18_16330	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
C7S18_16330	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C7S18_16335	COG3525	Glycosyl hydrolase, family 20, catalytic domain
C7S18_16345	COG2188	Transcriptional regulator
C7S18_16350	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C7S18_16355	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
C7S18_16370	COG1053	succinate dehydrogenase
C7S18_16385	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
C7S18_16390	COG0052	Belongs to the universal ribosomal protein uS2 family
C7S18_16405	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C7S18_16430	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C7S18_16435	COG0739	heme binding
C7S18_16455	COG3179	chitinase
C7S18_16475	COG2198	Histidine kinase
C7S18_16475	COG0643	Histidine kinase
C7S18_16480	COG0840	transmembrane signaling receptor activity
C7S18_16495	COG0745	RESPONSE REGULATOR receiver
C7S18_16505	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
C7S18_16505	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
C7S18_16510	COG3608	succinylglutamate desuccinylase aspartoacylase
C7S18_16510	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
C7S18_16525	COG2902	Dehydrogenase
C7S18_16540	COG0861	Integral membrane protein TerC family
C7S18_16555	COG0242	peptide deformylase activity
C7S18_16560	COG0308	aminopeptidase N
C7S18_16570	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
C7S18_16575	COG0745	RESPONSE REGULATOR receiver
C7S18_16575	COG2972	Histidine kinase
C7S18_16590	COG2815	serine threonine protein kinase
C7S18_16590	COG0515	serine threonine protein kinase
C7S18_16640	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
C7S18_16650	COG1254	Belongs to the acylphosphatase family
C7S18_16670	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
C7S18_16675	COG0248	Ppx GppA phosphatase
C7S18_16690	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
C7S18_16720	COG0617	tRNA 3'-terminal CCA addition
C7S18_16745	COG0697	spore germination
C7S18_16790	COG2957	Belongs to the agmatine deiminase family
C7S18_16795	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C7S18_16870	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
C7S18_16875	COG0583	DNA-binding transcription factor activity
C7S18_16880	COG3634	alkyl hydroperoxide reductase activity
C7S18_16895	COG4206	TonB-dependent receptor
C7S18_16905	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C7S18_16930	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
C7S18_16935	COG0740	serine-type endopeptidase activity
C7S18_16940	COG0544	peptidyl-prolyl cis-trans isomerase activity
C7S18_16985	COG0318	PFAM AMP-dependent synthetase and ligase
C7S18_17000	COG1404	Belongs to the peptidase S8 family
C7S18_17040	COG0174	glutamine synthetase
C7S18_17075	COG0596	Alpha beta hydrolase
C7S18_17080	COG1136	(ABC) transporter
C7S18_17080	COG0577	efflux transmembrane transporter activity
C7S18_17095	COG0577	efflux transmembrane transporter activity
C7S18_17095	COG1136	(ABC) transporter
C7S18_17110	COG0606	chelatase, subunit chli
C7S18_17135	COG0210	DNA helicase
C7S18_17140	COG2936	dipeptidyl-peptidase activity
C7S18_17145	COG4585	Histidine kinase
C7S18_17150	COG2815	serine threonine protein kinase
C7S18_17150	COG0515	serine threonine protein kinase
C7S18_17160	COG0564	pseudouridine synthase activity
C7S18_17170	COG0343	queuine tRNA-ribosyltransferase activity
C7S18_17175	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
C7S18_17205	COG0515	serine threonine protein kinase
C7S18_17205	COG2815	serine threonine protein kinase
C7S18_17215	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
C7S18_17260	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
C7S18_17265	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
C7S18_17290	COG1404	Belongs to the peptidase S8 family
C7S18_17335	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C7S18_17360	COG0577	efflux transmembrane transporter activity
C7S18_17360	COG1136	(ABC) transporter
C7S18_17365	COG0577	efflux transmembrane transporter activity
C7S18_17365	COG1136	(ABC) transporter
C7S18_17370	COG1136	(ABC) transporter
C7S18_17370	COG0577	efflux transmembrane transporter activity
C7S18_17380	COG1136	(ABC) transporter
C7S18_17380	COG0577	efflux transmembrane transporter activity
C7S18_17390	COG0789	Transcriptional regulator
C7S18_17395	COG1609	Transcriptional regulator
C7S18_17400	COG2211	Major facilitator Superfamily
C7S18_17410	COG4771	TonB-dependent receptor
C7S18_17430	COG3119	arylsulfatase activity
C7S18_17440	COG0126	phosphoglycerate kinase activity
C7S18_17445	COG0469	pyruvate kinase activity
C7S18_17470	COG0515	serine threonine protein kinase
C7S18_17470	COG2815	serine threonine protein kinase
C7S18_17490	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C7S18_17500	COG2204	response regulator
C7S18_17505	COG5001	Diguanylate cyclase
C7S18_17505	COG3300	MHYT domain
C7S18_17525	COG0109	protoheme IX farnesyltransferase activity
C7S18_17550	COG1960	acyl-CoA dehydrogenase activity
C7S18_17565	COG2937	Belongs to the GPAT DAPAT family
C7S18_17600	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
C7S18_17615	COG0793	Belongs to the peptidase S41A family
C7S18_17625	COG2234	aminopeptidase activity
C7S18_17645	COG0515	serine threonine protein kinase
C7S18_17645	COG2815	serine threonine protein kinase
C7S18_17675	COG2204	response regulator
C7S18_17710	COG3039	Transposase
C7S18_17830	COG0346	lactoylglutathione lyase activity
C7S18_17845	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C7S18_17850	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
C7S18_17855	COG0300	oxidoreductase activity
C7S18_17860	COG2095	MarC family integral membrane protein
C7S18_17870	COG1215	transferase activity, transferring glycosyl groups
C7S18_17880	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C7S18_17915	COG1028	Short-chain dehydrogenase reductase Sdr
C7S18_17925	COG0784	Response regulator, receiver
C7S18_17925	COG2205	protein histidine kinase activity
C7S18_17925	COG2198	Histidine kinase
C7S18_17940	COG2610	gluconate transmembrane transporter activity
C7S18_17950	COG1716	ATPase activity
C7S18_17985	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
C7S18_17990	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
C7S18_17995	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
C7S18_18000	COG0813	purine-nucleoside phosphorylase activity
C7S18_18005	COG0537	adenosine 5'-monophosphoramidase activity
C7S18_18010	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
C7S18_18015	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
C7S18_18020	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
C7S18_18055	COG1131	(ABC) transporter
C7S18_18060	COG0842	Transport permease protein
C7S18_18070	COG0346	lactoylglutathione lyase activity
C7S18_18115	COG0784	Response regulator, receiver
C7S18_18115	COG2205	protein histidine kinase activity
C7S18_18115	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C7S18_18115	COG2198	Histidine kinase
C7S18_18125	COG3038	cytochrome b561
C7S18_18140	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
C7S18_18160	COG0084	hydrolase, TatD family'
C7S18_18180	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
C7S18_18190	COG2084	Dehydrogenase
C7S18_18215	COG4585	Histidine kinase
C7S18_18220	COG2197	response regulator
C7S18_18230	COG1131	(ABC) transporter
C7S18_18250	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C7S18_18255	COG1946	Acyl-CoA thioesterase
C7S18_18265	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
C7S18_18270	COG3706	GGDEF domain
C7S18_18270	COG0745	RESPONSE REGULATOR receiver
C7S18_18275	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C7S18_18275	COG2205	protein histidine kinase activity
C7S18_18275	COG2198	Histidine kinase
C7S18_18275	COG0784	Response regulator, receiver
C7S18_18280	COG1272	protein, Hemolysin III
C7S18_18310	COG2815	serine threonine protein kinase
C7S18_18310	COG0515	serine threonine protein kinase
C7S18_18320	COG2815	serine threonine protein kinase
C7S18_18320	COG0515	serine threonine protein kinase
C7S18_18330	COG0501	Belongs to the peptidase M48B family
C7S18_18335	COG1704	LemA family
C7S18_18360	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
C7S18_18390	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
C7S18_18395	COG0706	membrane insertase activity
C7S18_18400	COG0594	ribonuclease P activity
C7S18_18405	COG0230	Belongs to the bacterial ribosomal protein bL34 family
C7S18_18420	COG2205	protein histidine kinase activity
C7S18_18425	COG0745	RESPONSE REGULATOR receiver
C7S18_18440	COG2833	Protein of unknown function (DUF455)
C7S18_18470	COG0412	Dienelactone hydrolase
C7S18_18515	COG0247	lactate metabolic process
C7S18_18525	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
C7S18_18530	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C7S18_18560	COG0442	prolyl-tRNA aminoacylation
C7S18_18565	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C7S18_18570	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C7S18_18580	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C7S18_18590	COG0515	serine threonine protein kinase
C7S18_18590	COG2815	serine threonine protein kinase
C7S18_18595	COG0515	serine threonine protein kinase
C7S18_18615	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
C7S18_18695	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C7S18_18730	COG5001	Diguanylate cyclase
C7S18_18730	COG3300	MHYT domain
C7S18_18735	COG2925	Exonuclease
C7S18_18740	COG0515	serine threonine protein kinase
C7S18_18740	COG2815	serine threonine protein kinase
C7S18_18750	COG4251	negative regulation of phosphorylation
C7S18_18750	COG3706	GGDEF domain
C7S18_18750	COG2203	Gaf domain
C7S18_18750	COG5001	Diguanylate cyclase
C7S18_18785	COG4682	membrane
C7S18_18795	COG0210	DNA helicase
C7S18_18910	COG3547	Transposase (IS116 IS110 IS902 family)
C7S18_18945	COG3795	YCII-related domain
C7S18_18980	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
C7S18_18985	COG2205	protein histidine kinase activity
C7S18_18990	COG4771	TonB-dependent receptor
C7S18_19000	COG0436	Aminotransferase
C7S18_19020	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
C7S18_19035	COG3227	Zinc metalloprotease (Elastase)
C7S18_19040	COG3813	Protein conserved in bacteria
C7S18_19045	COG2894	cell division
C7S18_19050	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C7S18_19065	COG0438	transferase activity, transferring glycosyl groups
C7S18_19130	COG0284	orotidine-5'-phosphate decarboxylase activity
C7S18_19225	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
C7S18_19225	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
C7S18_19295	COG0783	Belongs to the Dps family
C7S18_19300	COG1643	Atp-dependent helicase
C7S18_19310	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C7S18_19320	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
C7S18_19325	COG0719	Fe-S assembly protein
C7S18_19330	COG0396	ATPase activity
C7S18_19340	COG0719	Fe-S assembly protein
C7S18_19345	COG1959	2 iron, 2 sulfur cluster binding
C7S18_19360	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
C7S18_19365	COG0583	DNA-binding transcription factor activity
C7S18_19370	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C7S18_19370	COG1648	precorrin-2 dehydrogenase activity
C7S18_19405	COG4783	chaperone-mediated protein folding
C7S18_19440	COG2205	protein histidine kinase activity
C7S18_19445	COG0745	RESPONSE REGULATOR receiver
C7S18_19460	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
C7S18_19475	COG0437	4 iron, 4 sulfur cluster binding
C7S18_19580	COG0745	RESPONSE REGULATOR receiver
C7S18_19640	COG1902	pentaerythritol trinitrate reductase activity
C7S18_19645	COG1309	transcriptional regulator
C7S18_19675	COG2885	chlorophyll binding
C7S18_19675	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
C7S18_19825	COG3279	Response regulator of the LytR AlgR family
C7S18_19830	COG3275	phosphorelay sensor kinase activity
C7S18_19955	COG3039	Transposase
C7S18_19960	COG0318	PFAM AMP-dependent synthetase and ligase
C7S18_19965	COG3039	Transposase
C7S18_19980	COG0318	PFAM AMP-dependent synthetase and ligase
C7S18_19985	COG0302	gtp cyclohydrolase
C7S18_19990	COG1132	(ABC) transporter
C7S18_19995	COG4585	Histidine kinase
C7S18_20020	COG0457	Tetratricopeptide repeat
C7S18_20110	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
C7S18_20115	COG5000	phosphorelay sensor kinase activity
C7S18_20125	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C7S18_20125	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
C7S18_20130	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
C7S18_20140	COG0183	Belongs to the thiolase family
C7S18_20155	COG2824	Alkylphosphonate utilization operon protein PhnA
C7S18_20220	COG0708	Exodeoxyribonuclease III
C7S18_20235	COG5001	Diguanylate cyclase
C7S18_20235	COG2203	Gaf domain
C7S18_20235	COG3706	GGDEF domain
C7S18_20235	COG4251	negative regulation of phosphorylation
C7S18_20285	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
C7S18_20310	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
C7S18_20355	COG3012	SEC-C Motif Domain Protein
C7S18_20360	COG2815	serine threonine protein kinase
C7S18_20360	COG0515	serine threonine protein kinase
C7S18_20375	COG0187	DNA topoisomerase II activity
C7S18_20380	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
C7S18_20385	COG0592	DNA-directed DNA polymerase activity
C7S18_20390	COG4585	Histidine kinase
C7S18_20395	COG2197	response regulator
C7S18_20400	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C7S18_20405	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
C7S18_20445	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
C7S18_20465	COG2003	Belongs to the UPF0758 family
C7S18_20475	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C7S18_20505	COG0457	Tetratricopeptide repeat
C7S18_20505	COG0515	serine threonine protein kinase
C7S18_20520	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
C7S18_20525	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
C7S18_20540	COG0842	Transport permease protein
C7S18_20545	COG1131	(ABC) transporter
C7S18_20550	COG1714	RDD family
C7S18_20555	COG2922	Belongs to the Smg family
C7S18_20560	COG0758	DNA mediated transformation
C7S18_20580	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
C7S18_20580	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
C7S18_20585	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C7S18_20585	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C7S18_20610	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C7S18_20625	COG4115	mRNA cleavage
C7S18_20635	COG1024	Enoyl-CoA hydratase
C7S18_20645	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
C7S18_20680	COG1136	(ABC) transporter
C7S18_20680	COG0577	efflux transmembrane transporter activity
C7S18_20695	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
C7S18_20700	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
C7S18_20700	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
C7S18_20705	COG0626	cystathionine gamma-synthase activity
C7S18_20715	COG3186	Phenylalanine-4-hydroxylase
C7S18_20745	COG0456	acetyltransferase
C7S18_20750	COG0632	four-way junction helicase activity
C7S18_20755	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
C7S18_20760	COG0217	transcriptional regulatory protein
C7S18_20770	COG1131	(ABC) transporter
C7S18_20780	COG2205	protein histidine kinase activity
C7S18_20890	COG1011	Hydrolase
C7S18_20895	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
C7S18_20915	COG4585	Histidine kinase
C7S18_20925	COG2197	response regulator
C7S18_20955	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
C7S18_20970	COG1956	GAF domain-containing protein
C7S18_20980	COG0625	glutathione transferase activity
C7S18_21005	COG0583	DNA-binding transcription factor activity
C7S18_21010	COG2268	Band 7 protein
C7S18_21030	COG1162	GTPase activity
C7S18_21040	COG2205	protein histidine kinase activity
C7S18_21040	COG3437	response regulator, receiver
C7S18_21040	COG3850	Histidine kinase
C7S18_21040	COG4999	Histidine kinase
C7S18_21070	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
C7S18_21075	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
C7S18_21085	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
C7S18_21100	COG2183	response to ionizing radiation
C7S18_21105	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
C7S18_21115	COG2072	flavoprotein involved in K transport
C7S18_21130	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C7S18_21135	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C7S18_21160	COG3039	Transposase
C7S18_21230	COG1561	YicC-like family, N-terminal region
C7S18_21325	COG3039	Transposase
C7S18_21335	COG2234	aminopeptidase activity
C7S18_21340	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
C7S18_21345	COG0577	efflux transmembrane transporter activity
C7S18_21350	COG1741	Belongs to the pirin family
C7S18_21365	COG0543	2 iron, 2 sulfur cluster binding
C7S18_21365	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C7S18_21370	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C7S18_21385	COG1473	amidohydrolase
C7S18_21415	COG1752	Esterase of the alpha-beta hydrolase superfamily
C7S18_21420	COG4585	Histidine kinase
C7S18_21425	COG2197	response regulator
C7S18_21430	COG3590	peptidase
C7S18_21460	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C7S18_21495	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C7S18_21500	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C7S18_21515	COG1802	Transcriptional regulator
C7S18_21540	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
C7S18_21565	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C7S18_21570	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
C7S18_21600	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
C7S18_21605	COG0667	Aldo Keto reductase
C7S18_21610	COG3034	peptidoglycan biosynthetic process
C7S18_21615	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C7S18_21620	COG0626	cystathionine gamma-synthase activity
C7S18_21630	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
C7S18_21640	COG0668	transmembrane transport
C7S18_21650	COG0352	thiamine-phosphate diphosphorylase activity
C7S18_21655	COG1773	rubredoxin
C7S18_21675	COG2816	NAD+ diphosphatase activity
C7S18_21685	COG1678	Uncharacterized ACR, COG1678
C7S18_21695	COG1205	dead DEAH box helicase
C7S18_21695	COG1111	helicase
C7S18_21710	COG0577	efflux transmembrane transporter activity
C7S18_21710	COG1136	(ABC) transporter
C7S18_21715	COG1136	(ABC) transporter
C7S18_21715	COG0577	efflux transmembrane transporter activity
C7S18_21720	COG1136	(ABC) transporter
C7S18_21745	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
C7S18_21750	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
C7S18_21755	COG0628	permease
C7S18_21760	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
C7S18_21775	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
C7S18_21785	COG0318	PFAM AMP-dependent synthetase and ligase
C7S18_21805	COG0277	FAD linked oxidase domain protein
C7S18_21820	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
C7S18_21825	COG1461	Dihydroxyacetone kinase
C7S18_21865	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
C7S18_21885	COG3708	Transcriptional regulator
C7S18_21885	COG2207	Transcriptional regulator
C7S18_21925	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
C7S18_21930	COG0745	RESPONSE REGULATOR receiver
C7S18_21940	COG2884	Cell division ATP-binding protein ftsE
C7S18_21955	COG0540	Belongs to the ATCase OTCase family
C7S18_21965	COG2151	metal-sulfur cluster biosynthetic enzyme
C7S18_21975	COG1252	NADH dehydrogenase
C7S18_21980	COG1610	YqeY-like protein
C7S18_22000	COG0312	modulator of DNA gyrase
C7S18_22035	COG3267	Type II secretory pathway component ExeA
C7S18_22035	COG3409	Peptidoglycan-binding domain 1 protein
C7S18_22040	COG4942	peptidase
C7S18_22050	COG0047	phosphoribosylformylglycinamidine synthase activity
C7S18_22050	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
C7S18_22060	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
C7S18_22065	COG1459	type II secretion system
C7S18_22075	COG4970	Tfp pilus assembly protein FimT
C7S18_22080	COG4795	General secretion pathway protein
C7S18_22085	COG3156	type II secretion system protein K
C7S18_22090	COG3166	PFAM Fimbrial assembly family protein
C7S18_22105	COG1450	Type ii and iii secretion system protein
C7S18_22125	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C7S18_22160	COG0151	Belongs to the GarS family
C7S18_22190	COG1131	(ABC) transporter
C7S18_22205	COG3706	GGDEF domain
C7S18_22205	COG0745	RESPONSE REGULATOR receiver
C7S18_22230	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C7S18_22235	COG0625	glutathione transferase activity
C7S18_22260	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C7S18_22290	COG0037	tRNA processing
C7S18_22295	COG4191	Histidine kinase
C7S18_22300	COG2204	response regulator
C7S18_22310	COG1131	(ABC) transporter
C7S18_22315	COG0842	Transport permease protein
C7S18_22350	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
C7S18_22385	COG1595	DNA-templated transcription, initiation
C7S18_22405	COG1028	Short-chain dehydrogenase reductase Sdr
C7S18_22415	COG0017	Asparaginyl-tRNA synthetase
C7S18_22420	COG0316	Belongs to the HesB IscA family
C7S18_22425	COG0360	Binds together with S18 to 16S ribosomal RNA
C7S18_22430	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
C7S18_22440	COG3384	dioxygenase
C7S18_22450	COG0612	Peptidase, M16
C7S18_22520	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
C7S18_22550	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C7S18_22560	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
C7S18_22585	COG1074	ATP-dependent DNA helicase activity
C7S18_22590	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C7S18_22595	COG0720	synthase
C7S18_22615	COG2204	response regulator
C7S18_22645	COG1228	amidohydrolase
C7S18_22650	COG3178	'Phosphotransferase
C7S18_22655	COG1166	arginine decarboxylase activity
C7S18_22670	COG0824	Thioesterase
C7S18_22695	COG2885	chlorophyll binding
C7S18_22700	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
C7S18_22705	COG0602	queuosine metabolic process
C7S18_22720	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
C7S18_22740	COG4968	Prepilin-type N-terminal cleavage methylation domain
C7S18_22765	COG1028	Short-chain dehydrogenase reductase Sdr
C7S18_22770	COG1028	Short-chain dehydrogenase reductase Sdr
C7S18_22775	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
C7S18_22780	COG0156	8-amino-7-oxononanoate synthase activity
C7S18_22815	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
C7S18_22905	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
C7S18_22920	COG2814	Major facilitator Superfamily
C7S18_22935	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
C7S18_22985	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
C7S18_23000	COG2840	Smr protein MutS2
C7S18_23020	COG0110	maltose O-acetyltransferase activity
C7S18_23040	COG0438	transferase activity, transferring glycosyl groups
C7S18_23065	COG1215	transferase activity, transferring glycosyl groups
C7S18_23085	COG2192	nodulation
C7S18_23100	COG0438	transferase activity, transferring glycosyl groups
C7S18_23120	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
C7S18_23160	COG1366	Belongs to the anti-sigma-factor antagonist family
C7S18_23170	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C7S18_23190	COG0356	it plays a direct role in the translocation of protons across the membrane
C7S18_23200	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
C7S18_23205	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
C7S18_23220	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
C7S18_23225	COG0355	proton-transporting ATP synthase activity, rotational mechanism
C7S18_23260	COG0488	(ABC) transporter
C7S18_23265	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
C7S18_23270	COG4208	sulfate ABC transporter
C7S18_23275	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
C7S18_23280	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
C7S18_23295	COG1959	2 iron, 2 sulfur cluster binding
C7S18_23300	COG3038	cytochrome b561
C7S18_23320	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
C7S18_23335	COG0543	2 iron, 2 sulfur cluster binding
C7S18_23365	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
C7S18_23365	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C7S18_23440	COG1475	DNA binding
C7S18_23500	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
C7S18_23505	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
C7S18_23520	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
C7S18_23575	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
C7S18_23600	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
C7S18_23660	COG1192	Involved in chromosome partitioning
C7S18_23720	COG0675	Transposase, IS605 OrfB family
C7S18_23785	COG0305	Participates in initiation and elongation during chromosome replication
C7S18_23795	COG0210	DNA helicase
C7S18_23880	COG4372	Transposase
C7S18_23965	COG0629	single-stranded DNA binding
C7S18_24045	COG1002	Type II restriction enzyme, methylase subunits
C7S18_24070	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding