locus-tag	class	description
HXS70_00020	ENOG4105DHJ	ABC, transporter
HXS70_00050	ENOG4107UUG	Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity)
HXS70_00080	ENOG4105C8D	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity)
HXS70_00085	ENOG4107RJ1	sodium solute
HXS70_00110	ENOG4105C0H	protease
HXS70_00115	ENOG4108JQC	penicillin-binding protein 1A
HXS70_00125	ENOG4108VXP	Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity)
HXS70_00130	ENOG4105DAF	Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
HXS70_00140	ENOG4105D60	lipoprotein releasing system transmembrane protein
HXS70_00140	ENOG4105D60	lipoprotein releasing system transmembrane protein
HXS70_00145	ENOG4105CNA	YD repeat protein
HXS70_00165	ENOG4107TV1	YD repeat protein
HXS70_00220	ENOG4107VAM	peptidase, m28
HXS70_00230	ENOG4105C07	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity)
HXS70_00235	ENOG4105M02	This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity)
HXS70_00250	ENOG4105C9B	Cysteine desulfurase
HXS70_00260	ENOG4106PBJ	Serine threonine-protein kinase Pkn6
HXS70_00265	ENOG4108YY1	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity)
HXS70_00275	ENOG4108ZVT	methylmalonyl-coA epimerase
HXS70_00280	ENOG4107QX3	carboxylase
HXS70_00290	ENOG4108JIJ	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity)
HXS70_00295	ENOG4105D9Q	decarboxylase (Beta subunit)
HXS70_00300	ENOG4105HJX	Biotin- acetyl-CoA-carboxylase ligase
HXS70_00305	ENOG4105CYC	Transferase
HXS70_00315	ENOG4108I19	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity)
HXS70_00320	ENOG4105C1B	dTDP-glucose 4-6-dehydratase
HXS70_00325	ENOG4105CTQ	phosphohexokinase
HXS70_00335	ENOG4105CHT	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
HXS70_00340	ENOG4105C7K	acetolactate synthase
HXS70_00360	ENOG4105C52	Atpase, p-type (Transporting), had superfamily, subfamily ic
HXS70_00365	ENOG4105C1P	efflux transporter, rnd family, mfp subunit
HXS70_00375	ENOG4105C8P	)-transporter
HXS70_00440	ENOG4105CHR	reductase
HXS70_00450	ENOG4108Z02	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity)
HXS70_00455	ENOG4105CPQ	Dehydrogenase
HXS70_00465	ENOG4105EYW	Ion transport protein
HXS70_00470	ENOG41080E8	Transcriptional regulator, Spx MgsR family
HXS70_00475	ENOG4105CY0	Metallo-Beta-Lactamase
HXS70_00495	ENOG4105FE9	pseudouridine synthase
HXS70_00505	ENOG4105D6X	Specifically methylates guanosine-37 in various tRNAs (By similarity)
HXS70_00510	ENOG4105CG1	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity)
HXS70_00520	ENOG4105CAV	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity)
HXS70_00610	ENOG4105CCG	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity)
HXS70_00615	ENOG4105K8U	2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HXS70_00620	ENOG4105DUK	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity)
HXS70_00625	ENOG4105CDP	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity)
HXS70_00660	ENOG4105KJP	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HXS70_00680	ENOG4108Z2K	Cupin 2, conserved barrel domain protein
HXS70_00690	ENOG4105C6B	Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity)
HXS70_00710	ENOG4105EK0	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
HXS70_00715	ENOG4105KHV	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity)
HXS70_00720	ENOG4105K5M	30s ribosomal protein S16
HXS70_00740	ENOG4105VIE	preprotein translocase, subunit YajC
HXS70_00745	ENOG4105C6U	Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity)
HXS70_00750	ENOG4105CZ1	Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity)
HXS70_00760	ENOG4105K6T	rare lipoprotein A
HXS70_00765	ENOG4107FSS	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
HXS70_00770	ENOG41080YA	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity)
HXS70_00815	ENOG4105CNT	hydrolase family 2
HXS70_00820	ENOG4105CA4	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity)
HXS70_00830	ENOG4108UNN	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity)
HXS70_00835	ENOG4105K87	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal
HXS70_00840	ENOG41082SA	50s ribosomal protein l29
HXS70_00845	ENOG4108R70	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity)
HXS70_00850	ENOG4105CKE	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity)
HXS70_00855	ENOG41080P9	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity)
HXS70_00865	ENOG4105K7S	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity)
HXS70_00870	ENOG4105CFD	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HXS70_00875	ENOG4108542	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity)
HXS70_00880	ENOG4106U5A	One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity)
HXS70_00885	ENOG4105EEE	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity)
HXS70_00890	ENOG4108Z10	Involved in the binding of tRNA to the ribosomes (By similarity)
HXS70_00895	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
HXS70_00900	ENOG4108UHY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity)
HXS70_00905	ENOG4108UKE	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity)
HXS70_00920	ENOG4105BZU	Histidine kinase
HXS70_00940	ENOG4105C2V	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity)
HXS70_00955	ENOG4108M8S	permease YjgP YjgQ family protein
HXS70_00960	ENOG4105DKZ	GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity)
HXS70_00980	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
HXS70_00990	ENOG4105CSF	NADPH-dependent glycerol-3-phosphate dehydrogenase
HXS70_01020	ENOG4105CSG	Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity)
HXS70_01035	ENOG4105D86	that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity)
HXS70_01085	ENOG4105KEM	Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity)
HXS70_01090	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
HXS70_01105	ENOG4108IPT	Naphthoate synthase
HXS70_01140	ENOG4107T0D	ABC, transporter
HXS70_01155	ENOG4108IJ6	ABC transporter
HXS70_01165	ENOG4105EMU	Dehydrogenase
HXS70_01185	ENOG4108JUA	Transcriptional regulator
HXS70_01200	ENOG4105E2D	ec 3.2.1.52
HXS70_01215	ENOG4105CVK	Glutamate decarboxylase
HXS70_01225	ENOG4105C0B	DNA polymerase III (alpha subunit)
HXS70_01230	ENOG4107QYT	Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity)
HXS70_01235	ENOG4108UV6	Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity)
HXS70_01255	ENOG4105C37	(CBS) domain
HXS70_01260	ENOG4105C37	(CBS) domain
HXS70_01265	ENOG4105C62	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity)
HXS70_01270	ENOG4105K77	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity)
HXS70_01300	ENOG4105DI7	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity)
HXS70_01305	ENOG4108Z1W	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity)
HXS70_01320	ENOG4106855	Competence protein
HXS70_01340	ENOG4105E78	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity)
HXS70_01360	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
HXS70_01365	ENOG4107QQT	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity)
HXS70_01375	ENOG4105D7M	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
HXS70_01400	ENOG4105CPE	K01197 hyaluronoglucosaminidase EC 3.2.1.35
HXS70_01405	ENOG4108ZI0	d,d-heptose 1,7-bisphosphate phosphatase
HXS70_01410	ENOG4105F55	Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity)
HXS70_01415	ENOG4105DW0	Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity)
HXS70_01420	ENOG4108775	30S ribosomal protein S21
HXS70_01425	ENOG4105CDM	Glutamate-1-semialdehyde aminotransferase
HXS70_01435	ENOG4107QNK	)-transporter
HXS70_01450	ENOG4105CX6	glutaminyL-tRNA synthetase
HXS70_01455	ENOG4105C66	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity)
HXS70_01460	ENOG4108UTT	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity)
HXS70_01465	ENOG410803B	Involved in the transcription termination process (By similarity)
HXS70_01470	ENOG4105CCP	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)
HXS70_01475	ENOG4105C55	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs
HXS70_01480	ENOG4105CDU	Replicative dna helicase
HXS70_01495	ENOG4105CEV	competence damage-inducible protein
HXS70_01505	ENOG4108W0I	acetyltransferase
HXS70_01530	ENOG4105G6W	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity)
HXS70_01535	ENOG4108UHH	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity)
HXS70_01540	ENOG4108Z04	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HXS70_01545	ENOG4105EH2	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity)
HXS70_01560	ENOG4105C79	DNA protecting protein DprA
HXS70_01565	ENOG4105DZ1	carboxypeptidase
HXS70_01570	ENOG4105C3G	gtp-binding protein
HXS70_01585	ENOG4105CBI	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HXS70_01600	ENOG41061MV	Arylsulfatase
HXS70_01625	ENOG4105NQG	DoxX
HXS70_01630	ENOG4105CXB	phosphoribosylaminoimidazole synthetase
HXS70_01635	ENOG4105CBA	glutamine phosphoribosylpyrophosphate amidotransferase
HXS70_01640	ENOG4105EMN	RNA polymerase sigma factor
HXS70_01660	ENOG4105CJS	Phosphopantothenoylcysteine decarboxylase
HXS70_01680	ENOG4105CSR	polyphosphate kinase 2
HXS70_01685	ENOG4107EDW	L-fucose operon activator
HXS70_01705	ENOG4105C3J	Cysteine desulfurase
HXS70_01710	ENOG4105C3J	Cysteine desulfurase
HXS70_01720	ENOG4105E06	May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity)
HXS70_01735	ENOG4106H78	methyltransferase
HXS70_01750	ENOG4105CSR	polyphosphate kinase 2
HXS70_01760	ENOG41084I7	Alpha-galactosidase. Removes both branched alpha-1,3- linked galactose residues of blood group B antigens and linear alpha-1,3-linked galactose structures
HXS70_01765	ENOG41084I7	Alpha-galactosidase. Removes both branched alpha-1,3- linked galactose residues of blood group B antigens and linear alpha-1,3-linked galactose structures
HXS70_01775	ENOG4107XM9	(LipO)protein
HXS70_01780	ENOG4105K8N	protein family UPF0079, ATPase
HXS70_01790	ENOG4105K46	50S ribosomal protein l27
HXS70_01795	ENOG4105G5W	regulator Fur family
HXS70_01800	ENOG4105C3K	feS assembly ATPase SufC
HXS70_01805	ENOG4105DIW	FeS assembly protein SUFB
HXS70_01815	ENOG41089I4	Inherit from COG: Glycosyl transferase, family 2
HXS70_01825	ENOG4107QRH	Arylsulfatase (Ec 3.1.6.1)
HXS70_01830	ENOG4105CZF	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity)
HXS70_01875	ENOG4105CF4	DegT DnrJ EryC1 StrS aminotransferase
HXS70_01895	ENOG4105KNM	Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity)
HXS70_01900	ENOG4105C4J	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity)
HXS70_01905	ENOG4105J80	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity)
HXS70_01910	ENOG4105CDG	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity)
HXS70_01915	ENOG4107S15	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
HXS70_01930	ENOG4105EE4	it plays a direct role in the translocation of protons across the membrane (By similarity)
HXS70_01940	ENOG4105CJN	penicillin-binding protein
HXS70_01980	ENOG4105D06	uba thif-type nad fad binding protein
HXS70_01985	ENOG4105C2X	Arabinose 5-phosphate isomerase
HXS70_02005	ENOG4105D7W	serine acetyltransferase
HXS70_02015	ENOG4105C2S	Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity)
HXS70_02020	ENOG4105CGT	Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity)
HXS70_02035	ENOG4107QPR	SAICAR synthetase
HXS70_02045	ENOG4108JIU	phosphoribosylformylglycinamidine synthase ii
HXS70_02050	ENOG4105D21	Phosphoribosylformylglycinamidine synthase I
HXS70_02060	ENOG4105CN9	Peptidase m42 family protein
HXS70_02080	ENOG4105C03	ribonuclease
HXS70_02100	ENOG4109015	Biopolymer transport protein exbD tolR
HXS70_02115	ENOG4105CSM	endonuclease III
HXS70_02130	ENOG4105DK0	Indole-3-glycerol phosphate synthase
HXS70_02135	ENOG41080R2	UPF0102 protein
HXS70_02145	ENOG4105C37	(CBS) domain
HXS70_02155	ENOG41082R9	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity)
HXS70_02160	ENOG4105CDH	Citrulline--aspartate ligase
HXS70_02165	ENOG4107QRH	Arylsulfatase (Ec 3.1.6.1)
HXS70_02175	ENOG4105CP7	Triose-phosphate isomerase
HXS70_02180	ENOG4106855	Competence protein
HXS70_02190	ENOG4107QRH	Arylsulfatase (Ec 3.1.6.1)
HXS70_02205	ENOG41081UC	Inherit from COG: Competence protein
HXS70_02215	ENOG4105DXN	mazG family
HXS70_02235	ENOG4105CHD	Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity)
HXS70_02245	ENOG4107RAN	Peptidase, M16
HXS70_02250	ENOG4105WPN	DNA integration recombination invertion protein
HXS70_02255	ENOG4107R11	Transcriptional regulator
HXS70_02260	ENOG4105SYT	Methylenetetrahydrofolate reductase
HXS70_02280	ENOG4105DGA	Diaminopimelate dehydrogenase
HXS70_02285	ENOG4105F7V	ErfK ybiS ycfS ynhG family protein
HXS70_02305	ENOG4105C7B	Threonine dehydratase
HXS70_02310	ENOG4108Z03	MAF-like protein
HXS70_02315	ENOG4105C1N	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity)
HXS70_02335	ENOG4105CG2	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity)
HXS70_02345	ENOG4105CAT	Cytidine monophosphate kinase
HXS70_02355	ENOG4105C3X	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity)
HXS70_02365	ENOG4108ZBM	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity)
HXS70_02380	ENOG4105CGK	Exodeoxyribonuclease III
HXS70_02385	ENOG4105CU0	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity)
HXS70_02400	ENOG4105K8F	Phosphoribosyl-amp cyclohydrolase
HXS70_02405	ENOG4107QRG	dna polymerase iii
HXS70_02435	ENOG4108WVK	Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity)
HXS70_02455	ENOG4105W5A	BNR Asp-box repeat protein
HXS70_02620	ENOG4108N0N	Phage Terminase Large Subunit
HXS70_02730	ENOG4105CKJ	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity)
HXS70_02735	ENOG4105CCZ	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity)
HXS70_02740	ENOG4107EER	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity)
HXS70_02745	ENOG4105K64	Glycosyl transferase, family 2
HXS70_02755	ENOG4105C5S	asparaginyl-tRNA synthetase
HXS70_02765	ENOG4105K63	Thioredoxin
HXS70_02815	ENOG4105HMI	Membrane
HXS70_02820	ENOG4107STF	Involved in phosphonate degradation (By similarity)
HXS70_02840	ENOG4105EIZ	Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity)
HXS70_02845	ENOG4105C4P	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity)
HXS70_02850	ENOG4105CDY	transcriptional regulatory protein
HXS70_02860	ENOG4105CKD	glutathione-regulated potassium-efflux system protein
HXS70_02870	ENOG4105E2N	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity)
HXS70_02875	ENOG4105DI5	UPF0365 protein
HXS70_02885	ENOG4105CA8	Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity)
HXS70_02890	ENOG4107RY6	amino acid
HXS70_02900	ENOG4105DSF	transport protein
HXS70_02905	ENOG4105CU5	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity)
HXS70_02910	ENOG4107RCW	fructose-bisphosphate aldolase
HXS70_02915	ENOG4105CI3	gtp-binding protein typa
HXS70_02920	ENOG4105CM2	brancheD-chain amino acid aminotransferase
HXS70_02945	ENOG4105C9R	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HXS70_02955	ENOG4105CPF	Cell wall formation (By similarity)
HXS70_03040	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
HXS70_03055	ENOG4108VXP	Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity)
HXS70_03080	ENOG4105E99	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity)
HXS70_03085	ENOG4105X0D	Fimbrial protein
HXS70_03095	ENOG4108Z2X	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity)
HXS70_03105	ENOG4105D0T	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity)
HXS70_03115	ENOG4105DIN	metallophosphoesterase
HXS70_03135	ENOG4105CUI	Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity)
HXS70_03140	ENOG4105K64	Glycosyl transferase, family 2
HXS70_03160	ENOG4105EXC	Acyl-transferase
HXS70_03175	ENOG4107QWE	)-transporter
HXS70_03210	ENOG4105DKJ	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
HXS70_03215	ENOG4105C5I	Dehydrogenase
HXS70_03225	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
HXS70_03230	ENOG4105NAU	thioesterase Superfamily protein
HXS70_03240	ENOG4105CYX	Short-chain dehydrogenase reductase Sdr
HXS70_03250	ENOG4105KK6	nuclease
HXS70_03260	ENOG4105GTN	ParB Domain Protein Nuclease
HXS70_03265	ENOG4105BZV	Phosphoadenosine phosphosulfate reductase
HXS70_03420	ENOG4105CDU	Replicative dna helicase
HXS70_03530	ENOG4105C0C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity)
HXS70_03545	ENOG4105C0P	Mg chelatase subunit ChlI
HXS70_03565	ENOG4105EZY	Pyrroloquinoline quinone biosynthesis protein E
HXS70_03580	ENOG4105CSF	NADPH-dependent glycerol-3-phosphate dehydrogenase
HXS70_03585	ENOG4105K7Z	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity)
HXS70_03595	ENOG4105CRK	lysyL-tRNA synthetase
HXS70_03615	ENOG4105KVH	Transcriptional regulator
HXS70_03625	ENOG4105C0S	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity)
HXS70_03640	ENOG4105CQ7	ATP-dependent helicase
HXS70_03645	ENOG4108ZP8	Acetolactate synthase small subunit
HXS70_03650	ENOG4105C0H	protease
HXS70_03660	ENOG4107RE5	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity)
HXS70_03665	ENOG4105D1W	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity)
HXS70_03670	ENOG4105CAJ	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity)
HXS70_03680	ENOG4105CZ8	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity)
HXS70_03740	ENOG4105F8V	Hydrolase, tatD family
HXS70_03750	ENOG4105CNT	hydrolase family 2
HXS70_03765	ENOG4105C08	Histidine kinase
HXS70_03770	ENOG4105EEX	Two component transcriptional regulator (Winged helix family
HXS70_03780	ENOG4105D9K	One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity)
HXS70_03790	ENOG4108R80	One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity)
HXS70_03805	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
HXS70_03850	ENOG4108Z11	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity)
HXS70_03860	ENOG4105CHH	sulfate transporter
HXS70_03865	ENOG4105CH7	arginosuccinase
HXS70_03880	ENOG4105C70	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity)
HXS70_03885	ENOG4105EFU	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity)
HXS70_03910	ENOG4105EQI	Metal Dependent Phosphohydrolase
HXS70_03920	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
HXS70_03925	ENOG4105BZT	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity)
HXS70_03950	ENOG4105DME	alpha-galactosidase
HXS70_03980	ENOG4105D0C	transport protein
HXS70_03995	ENOG4105C8P	)-transporter
HXS70_04025	ENOG4108RAC	Rubrerythrin
HXS70_04035	ENOG4105CN9	Peptidase m42 family protein
HXS70_04040	ENOG4105E2D	ec 3.2.1.52
HXS70_04050	ENOG4105G6Z	alkaline phosphatase
HXS70_04055	ENOG4105M2E	Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity)
HXS70_04060	ENOG4105C8Y	Acetylornithine aminotransferase
HXS70_04080	ENOG4105C59	p-type ATPase
HXS70_04085	ENOG4105C4F	May be involved in recombinational repair of damaged DNA (By similarity)
HXS70_04090	ENOG4108H5C	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity)
HXS70_04095	ENOG4108UHC	Glycosyl transferase, wecb taga cpsf family
HXS70_04135	ENOG4105CPP	Dehydrogenase, E1 component
HXS70_04140	ENOG4105C2V	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity)
HXS70_04145	ENOG4108Z6Z	Transcriptional regulator
HXS70_04150	ENOG4105C1P	efflux transporter, rnd family, mfp subunit
HXS70_04155	ENOG4105BZS	acriflavin resistance protein
HXS70_04190	ENOG4105C9U	ATP-dependent DNA helicase RecQ
HXS70_04210	ENOG4108VPC	n-acetylmuramoyl-l-alanine amidase
HXS70_04215	ENOG4107QM5	aconitate hydratase
HXS70_04245	ENOG4105E0Y	RtcB Protein
HXS70_04255	ENOG4105CZM	Major Facilitator
HXS70_04265	ENOG4108WBT	adenosyltransferase
HXS70_04275	ENOG4105C40	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity)
HXS70_04300	ENOG4105CFP	Peptidase U32
HXS70_04305	ENOG4105DPM	folylpolyglutamate synthase Dihydrofolate synthase
HXS70_04320	ENOG410823G	oxidoreductase
HXS70_04325	ENOG4105C0D	helicase
HXS70_04330	ENOG4105CGH	5'-nucleotidase
HXS70_04335	ENOG4105K6T	rare lipoprotein A
HXS70_04340	ENOG4105F91	Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity)
HXS70_04345	ENOG41082A0	One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity)
HXS70_04360	ENOG4108R5J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity)
HXS70_04365	ENOG4105K4C	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity)
HXS70_04370	ENOG4108RA9	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity)
HXS70_04375	ENOG4108UZ0	Binds to the 23S rRNA (By similarity)
HXS70_04380	ENOG4105CGG	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity)
HXS70_04385	ENOG4105CC8	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity)
HXS70_04390	ENOG4105CA1	Removes the N-terminal methionine from nascent proteins (By similarity)
HXS70_04405	ENOG4105CUU	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity)
HXS70_04420	ENOG4107QRS	glycosyltransferase group 2 family protein
HXS70_04430	ENOG4105K64	Glycosyl transferase, family 2
HXS70_04445	ENOG4105K64	Glycosyl transferase, family 2
HXS70_04450	ENOG4108Z0Z	intracellular protease Pfpi family
HXS70_04455	ENOG4105C7S	Dehydrogenase
HXS70_04460	ENOG4105CE4	GlcNAc 6-P deacetylase
HXS70_04465	ENOG4107XH4	PPIases accelerate the folding of proteins (By similarity)
HXS70_04485	ENOG4105ENH	Sulfatase
HXS70_04495	ENOG41084NN	Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity)
HXS70_04500	ENOG4107EEM	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity)
HXS70_04505	ENOG4105CHV	Transcription elongation factor NusA
HXS70_04510	ENOG4105CGK	Exodeoxyribonuclease III
HXS70_04515	ENOG4108V82	Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity)
HXS70_04535	ENOG4105IDI	abc transporter atp-binding protein
HXS70_04555	ENOG4105VFU	Rna-binding protein
HXS70_04560	ENOG4105D3Q	Sugar transferase
HXS70_04580	ENOG4105CAE	Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity)
HXS70_04585	ENOG4108QBV	Monogalactosyldiacylglycerol synthase
HXS70_04590	ENOG4105CGM	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity)
HXS70_04595	ENOG4105VNB	Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity)
HXS70_04610	ENOG4108YYA	Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity)
HXS70_04645	ENOG4105CNA	YD repeat protein
HXS70_04655	ENOG4105E33	succinate dehydrogenase
HXS70_04690	ENOG4105K64	Glycosyl transferase, family 2
HXS70_04725	ENOG4107TAE	Glycosyl transferase (Group 1
HXS70_04745	ENOG4105DKX	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity)
HXS70_04770	ENOG4105UYK	outer membrane protein a
HXS70_04775	ENOG4105DFU	Cell wall formation (By similarity)
HXS70_04785	ENOG4108IUZ	ABC transporter
HXS70_04800	ENOG4105CXR	Phospho-2-dehydro-3-deoxyoctonate aldolase
HXS70_04810	ENOG4105CE9	30S ribosomal protein S2
HXS70_04815	ENOG4105CU7	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity)
HXS70_04825	ENOG4108JQ7	(ABC) transporter
HXS70_04830	ENOG4105D49	3-dehydroquinate synthase
HXS70_04840	ENOG4105C0H	protease
HXS70_04850	ENOG4105MQS	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
HXS70_04855	ENOG4105CQI	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
HXS70_04860	ENOG4108BDP	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity)
HXS70_04865	ENOG4108KNB	n-acetylmuramoyl-l-alanine amidase
HXS70_04870	ENOG4105C68	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity)
HXS70_04880	ENOG4105CPF	Cell wall formation (By similarity)
HXS70_04885	ENOG4105DFU	Cell wall formation (By similarity)
HXS70_04890	ENOG4105DVQ	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity)
HXS70_04895	ENOG4105CNI	cell division protein FtsW
HXS70_04905	ENOG4105DMZ	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity)
HXS70_04910	ENOG4105CPY	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity)
HXS70_04915	ENOG4107EES	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity)
HXS70_04920	ENOG4107EEN	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity)
HXS70_04925	ENOG4105CJN	penicillin-binding protein
HXS70_04930	ENOG4105CJN	penicillin-binding protein
HXS70_04940	ENOG4105CGJ	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity)
HXS70_04945	ENOG4108V6E	Cell division protein mraZ
HXS70_04950	ENOG4105CY0	Metallo-Beta-Lactamase
HXS70_04955	ENOG4105EN6	Membrane
HXS70_04965	ENOG4105C1H	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity)
HXS70_04970	ENOG4105CCJ	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity)
HXS70_04990	ENOG4105CHR	reductase
HXS70_05000	ENOG4105C5H	ABC transporter
HXS70_05010	ENOG4105MS2	ribosomal subunit Interface protein
HXS70_05025	ENOG4107EXU	Short-chain dehydrogenase reductase Sdr
HXS70_05035	ENOG4105ENX	hydrolase
HXS70_05045	ENOG4105CPC	Aldo Keto reductase
HXS70_05065	ENOG4105DY9	regulatoR
HXS70_05100	ENOG4105D3C	The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity)
HXS70_05105	ENOG41076UM	multiple antibiotic resistance (MarC)-related protein
HXS70_05145	ENOG4107XH4	PPIases accelerate the folding of proteins (By similarity)
HXS70_05150	ENOG4105C5H	ABC transporter
HXS70_05155	ENOG410631K	Membrane
HXS70_05165	ENOG4105C8N	cysteinyl-tRNA synthetase
HXS70_05170	ENOG4105E2D	ec 3.2.1.52
HXS70_05175	ENOG4105CBG	Sulfatase
HXS70_05185	ENOG4105C4S	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity)
HXS70_05205	ENOG4107QR0	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
HXS70_05210	ENOG4107QIH	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
HXS70_05215	ENOG4105KBC	Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity)
HXS70_05220	ENOG4107Z3D	50S ribosomal protein l10
HXS70_05225	ENOG4105C64	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity)
HXS70_05230	ENOG4108UIK	This protein binds directly to 23S ribosomal RNA (By similarity)
HXS70_05235	ENOG4105E5V	Participates in transcription elongation, termination and antitermination (By similarity)
HXS70_05250	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
HXS70_05260	ENOG4105CPM	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
HXS70_05270	ENOG4105CCQ	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity)
HXS70_05275	ENOG4105DEA	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation
HXS70_05280	ENOG4105E1Z	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HXS70_05290	ENOG4105SYT	Methylenetetrahydrofolate reductase
HXS70_05310	ENOG4108IJF	Heavy metal efflux pump, CzcA
HXS70_05355	ENOG4105DA6	Catalyzes the conversion of 5-methoxyuridine (mo5U) to uridine-5-oxyacetic acid (cmo5U) at position 34 in tRNA. May also participate in the methylation of uridine-5-oxyacetic acid (cmo5U) to uridine-5-oxyacetic acid methyl ester (mcmo5U) (By similarity)
HXS70_05360	ENOG4105CPH	Catalyzes the formation of S-adenosylmethionine from methionine and ATP
HXS70_05365	ENOG4105C3E	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity)
HXS70_05390	ENOG4105CBG	Sulfatase
HXS70_05395	ENOG4105C9U	ATP-dependent DNA helicase RecQ
HXS70_05405	ENOG4107XB0	Lipopolysaccharide 1,2-N-acetylglucosaminetransferase
HXS70_05415	ENOG4108IYU	L-aspartate oxidase
HXS70_05475	ENOG4105CA0	peroxidase
HXS70_05480	ENOG4105C0G	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity)
HXS70_05485	ENOG4108Z6B	deaminase
HXS70_05490	ENOG4105DKQ	ROK family
HXS70_05495	ENOG4105C59	p-type ATPase
HXS70_05500	ENOG4105C4P	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity)
HXS70_05505	ENOG4105GVR	general secretion pathway protein D
HXS70_05535	ENOG4105C3B	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity)
HXS70_05545	ENOG4107RAQ	aminopeptidase
HXS70_05550	ENOG4105E21	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity)
HXS70_05575	ENOG4105BZU	Histidine kinase
HXS70_05580	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
HXS70_05585	ENOG4105C01	Dihydroxy-acid dehydratase
HXS70_05640	ENOG4105E0M	Sulfatase
HXS70_05675	ENOG4105CMR	udp-glucose 4-epimerase
HXS70_05680	ENOG4105D1X	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity)
HXS70_05700	ENOG4107QI1	Mate efflux family protein
HXS70_05865	ENOG4105D9K	One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity)
HXS70_05870	ENOG4105C8X	One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity)
HXS70_05875	ENOG4108R80	One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity)
HXS70_05885	ENOG4105E46	N-alpha,N-alpha,N-alpha-trimethyl-L-histidine metabolic process
HXS70_05895	ENOG4108RW0	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity)
HXS70_05915	ENOG4105V75	Transcriptional regulator
HXS70_05960	ENOG4105C7R	Atpase associated with various cellular activities aaa_3
HXS70_05990	ENOG4105ECP	epimerase
HXS70_06000	ENOG4105C6M	Alpha-keto-beta-hydroxylacyl reductoisomerase
HXS70_06005	ENOG4105DKW	ABC transporter
HXS70_06010	ENOG4105C6F	GntR Family Transcriptional Regulator
HXS70_06025	ENOG4107QRH	Arylsulfatase (Ec 3.1.6.1)
HXS70_06035	ENOG4105C70	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity)
HXS70_06045	ENOG4105CJ2	(LipO)protein
HXS70_06060	ENOG41085AM	50S ribosomal protein L28
HXS70_06070	ENOG41080G3	Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity)
HXS70_06075	ENOG4105CJT	Mannose-1-phosphate guanylyltransferase
HXS70_06085	ENOG4105DNX	Dna topoisomerase iv (Subunit b)
HXS70_06090	ENOG4105CTR	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity)
HXS70_06100	ENOG4105DVT	helicase
HXS70_06105	ENOG4108JJB	ABC transporter
HXS70_06130	ENOG4105CAS	nag kinase
HXS70_06135	ENOG4107QUT	magnesium and cobalt transport protein CorA
HXS70_06140	ENOG4105K9Q	Binds to the 23S rRNA (By similarity)
HXS70_06145	ENOG4105DC1	bifunctional purine biosynthesis protein purh
HXS70_06150	ENOG4105CSZ	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity)
HXS70_06155	ENOG410829W	Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity)
HXS70_06165	ENOG4105C0M	Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle (By similarity)
HXS70_06170	ENOG4108VPC	n-acetylmuramoyl-l-alanine amidase
HXS70_06185	ENOG4107SFQ	iron-sulfur binding
HXS70_06205	ENOG4105D49	3-dehydroquinate synthase
HXS70_06265	ENOG4105SKN	orotidine 5''-phosphate decarboxylase
HXS70_06285	ENOG410816I	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity)
HXS70_06290	ENOG4105C6E	dna polymerase iii
HXS70_06310	ENOG4105W5Q	DNA repair protein (RadC
HXS70_06315	ENOG4105DR1	Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity)
HXS70_06320	ENOG4105K9U	however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity)
HXS70_06325	ENOG4108UM5	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity)
HXS70_06330	ENOG4108UJD	30S ribosomal protein S9
HXS70_06335	ENOG4108UXA	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity)
HXS70_06340	ENOG4105CII	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity)
HXS70_06350	ENOG4109015	Biopolymer transport protein exbD tolR
HXS70_06360	ENOG4108JQC	penicillin-binding protein 1A
HXS70_06365	ENOG4105ECY	inositol monophosphatase
HXS70_06370	ENOG4108UH8	Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity)
HXS70_06450	ENOG4105DG6	mannose-6-phosphate isomerase
HXS70_06460	ENOG4105DFD	Na H antiporter
HXS70_06465	ENOG4105C30	Nad-dependent epimerase dehydratase
HXS70_06470	ENOG4105C0K	Gdp-mannose 4,6-dehydratase
HXS70_06475	ENOG4105C1M	carbamoyl-phosphate synthetase glutamine chain
HXS70_06480	ENOG4105CU6	carbamoyl-phosphate synthetase ammonia chain
HXS70_06490	ENOG4105CBC	glutamate synthase
HXS70_06495	ENOG4105DHW	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
HXS70_06500	ENOG4105VAS	Could be involved in insertion of integral membrane proteins into the membrane (By similarity)
HXS70_06530	ENOG4105DSB	aldose 1-epimerase
HXS70_06540	ENOG4105D18	nicotinate-nucleotide pyrophosphorylase
HXS70_06550	ENOG4105CM3	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity)
HXS70_06570	ENOG4105C3M	thioredoxin reductase
HXS70_06620	ENOG4105CKD	glutathione-regulated potassium-efflux system protein
HXS70_06625	ENOG4105DIN	metallophosphoesterase
HXS70_06635	ENOG4108V3E	phosphoribosylglycinamide formyltransferase
HXS70_06640	ENOG4108V1T	peptidylprolyl cis-trans isomerase
HXS70_06655	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
HXS70_06665	ENOG4105CFP	Peptidase U32
HXS70_06670	ENOG4105E6M	Sulphatase-modifying factor protein
HXS70_06690	ENOG4105ET1	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity)
HXS70_06710	ENOG4105C3T	may be the GTPase, regulating ATP sulfurylase activity (By similarity)
HXS70_06715	ENOG4105C3T	may be the GTPase, regulating ATP sulfurylase activity (By similarity)
HXS70_06720	ENOG4105C11	sulfate adenylyltransferase), subunit 2
HXS70_06735	ENOG4108UTW	Plays a role in the regulation of phosphate uptake
HXS70_06740	ENOG4105BZY	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity)
HXS70_06745	ENOG4105E2Z	phosphate ABC transporter (Permease
HXS70_06750	ENOG4105C8U	phosphate abc transporter
HXS70_06755	ENOG4105DJH	phosphate
HXS70_06760	ENOG4105BZY	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity)
HXS70_06765	ENOG4108UTW	Plays a role in the regulation of phosphate uptake
HXS70_06770	ENOG4105ENN	converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity)
HXS70_06785	ENOG4105C1V	Peptidase, M16
HXS70_06795	ENOG4108UW5	maltose o-acetyltransferase
HXS70_06820	ENOG4108VCV	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity)
HXS70_06825	ENOG4105C41	Catalyzes the reversible phosphorylation of UMP to UDP (By similarity)
HXS70_06835	ENOG4105D3R	alkyl hydroperoxide reductase
HXS70_06840	ENOG4105C8J	)-transporter
HXS70_06865	ENOG4105C0Q	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity)
HXS70_06870	ENOG4105E0X	reductase
HXS70_06875	ENOG4105CQ3	Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity)
HXS70_07115	ENOG4105CDU	Replicative dna helicase
HXS70_07130	ENOG4107QWP	ABC-2 type transporter
HXS70_07135	ENOG4107QWP	ABC-2 type transporter
HXS70_07140	ENOG4105CJ1	ABC, transporter
HXS70_07150	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
HXS70_07155	ENOG4106PT6	cdpdiacylglycerol-serine O-phosphatidyltransferase
HXS70_07165	ENOG4105EEI	dihydropteroate synthase
HXS70_07175	ENOG4105C4E	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity)
HXS70_07180	ENOG4105CHR	reductase
HXS70_07200	ENOG4107EEK	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity)
HXS70_07220	ENOG4105C9M	aspartyl-trna synthetase
HXS70_07225	ENOG4105CUT	histidyl-tRNA synthetase
HXS70_07245	ENOG4105CQS	hydrogenase expression formation protein HypD
HXS70_07250	ENOG4105C45	hydrogenase expression formation protein (HypE)
HXS70_07265	ENOG4105BZF	Glycosyl transferase (Group 1
HXS70_07270	ENOG4105CFG	Acts as a chaperone (By similarity)
HXS70_07275	ENOG4105K5Y	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity)
HXS70_07280	ENOG4105CJ9	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
HXS70_07315	ENOG4105D75	Capsular exopolysaccharide family
HXS70_07330	ENOG4105KA4	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity)
HXS70_07340	ENOG4105BZA	Phosphoglycerate kinase
HXS70_07350	ENOG4105CGS	Alpha-glucosidase
HXS70_07355	ENOG4105D9P	serine threonine protein kinase
HXS70_07360	ENOG4105D9P	serine threonine protein kinase
HXS70_07365	ENOG4108JA2	transcriptioN-repair coupling factor
HXS70_07375	ENOG4105DJB	Major Facilitator Superfamily
HXS70_07390	ENOG4107RVV	histidinol phosphate phosphatase, hisj family
HXS70_07395	ENOG4105C6K	Malic enzyme
HXS70_07400	ENOG4105D3U	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity)
HXS70_07405	ENOG4105NRA	50s ribosomal protein l31 type b
HXS70_07445	ENOG4105C6Y	Udp-glucose 6-dehydrogenase
HXS70_07450	ENOG4105D9Z	Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity)
HXS70_07470	ENOG4108RCM	Nitroreductase
HXS70_07475	ENOG4105C34	Pseudouridine synthase
HXS70_07480	ENOG4105I08	Pseudouridine synthase
HXS70_07500	ENOG4105CDA	abc transporter atp-binding protein
HXS70_07505	ENOG4105E5Q	amino acid AbC transporter
HXS70_07515	ENOG4105C0N	N-acetylglutamate semialdehyde dehydrogenase
HXS70_07520	ENOG4105C5V	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity)
HXS70_07570	ENOG4105VZ9	UPF0235 protein
HXS70_07575	ENOG4105K90	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HXS70_07580	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
HXS70_07585	ENOG4105QF0	Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity)
HXS70_07595	ENOG41084I7	Alpha-galactosidase. Removes both branched alpha-1,3- linked galactose residues of blood group B antigens and linear alpha-1,3-linked galactose structures
HXS70_07610	ENOG4105CQB	FAD linked oxidase domain protein
HXS70_07635	ENOG4105C5T	Phosphoribosyl pyrophosphate synthase
HXS70_07640	ENOG4105KW6	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity)
HXS70_07650	ENOG4105ECC	imidazole-glycerol-phosphate dehydratase
HXS70_07655	ENOG4108UJE	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity)
HXS70_07660	ENOG4107Q5Z	Binds together with S18 to 16S ribosomal RNA (By similarity)
HXS70_07665	ENOG4105CEZ	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity)
HXS70_07680	ENOG4105DZ1	carboxypeptidase
HXS70_07685	ENOG4105CTQ	phosphohexokinase
HXS70_07695	ENOG4105DUN	Mediates zinc uptake. May also transport other divalent cations (By similarity)
HXS70_07700	ENOG4105MH8	Thioredoxin disulfide isomerase
HXS70_07720	ENOG4105JKW	Valine--pyruvate aminotransferase
HXS70_07725	ENOG4105DSJ	YicC domain protein
HXS70_07740	ENOG4106F3G	Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity)
HXS70_07755	ENOG4105EIS	1,4-dihydroxy-2-naphthoate octaprenyltransferase
HXS70_07775	ENOG4105DBW	Multi-copper polyphenol oxidoreductase laccase
HXS70_07790	ENOG4105C3D	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
HXS70_07800	ENOG4105EHH	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue (By similarity)
HXS70_07810	ENOG4105CTF	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
HXS70_07815	ENOG4108ZT0	50S ribosomal protein l17
HXS70_07820	ENOG4105CJF	Malonyl coA-acyl carrier protein transacylase
HXS70_07830	ENOG4107YBY	Hydrolase
HXS70_07845	ENOG4105KCK	Peptidoglycan-associated lipoprotein
HXS70_07880	ENOG4105C0D	helicase
HXS70_07890	ENOG4107QMH	DNA methylase
HXS70_07920	ENOG4105CPC	Aldo Keto reductase
HXS70_07925	ENOG4105EAY	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
HXS70_07940	ENOG4105CRQ	synthase (Component I)
HXS70_07945	ENOG4108I0Q	anthranilate phosphoribosyltransferase
HXS70_07950	ENOG4105DK0	Indole-3-glycerol phosphate synthase
HXS70_07955	ENOG4108ZGB	N-(5'-phosphoribosyl)anthranilate isomerase
HXS70_07960	ENOG4105CG0	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity)
HXS70_07965	ENOG4105F6H	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity)
HXS70_07980	ENOG4105DWV	Homoserine O-trans-acetylase
HXS70_07985	ENOG4105YK5	50S ribosomal protein L36
HXS70_07995	ENOG4105F1A	Pyruvate formate-lyase
HXS70_08025	ENOG4108HCJ	Hydrolase
HXS70_08030	ENOG4105KWU	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
HXS70_08035	ENOG4106UW1	Major Facilitator superfamily
HXS70_08080	ENOG4106H6R	UPF0380 protein
HXS70_08145	ENOG4105YB8	TM2 domain containing protein
HXS70_08165	ENOG4105D9P	serine threonine protein kinase
HXS70_08180	ENOG4107R3N	Filamentation induced by cAMP protein fic
HXS70_08215	ENOG4105VJV	50s ribosomal protein L35
HXS70_08220	ENOG4108YZX	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity)
HXS70_08225	ENOG4105DZP	Membrane-associated zinc metalloprotease
HXS70_08245	ENOG4107QKA	exodeoxyribonuclease V beta
HXS70_08255	ENOG410631K	Membrane
HXS70_08265	ENOG4105D85	methylase
HXS70_08270	ENOG4105F6A	helicase
HXS70_08275	ENOG4105ECI	YeeC-like protein
HXS70_08280	ENOG4107S85	alpha-2-macroglobulin domain protein
HXS70_08285	ENOG4107QW4	alcohol dehydrogenase
HXS70_08295	ENOG4105K85	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity)
HXS70_08320	ENOG4105BZN	citrate synthase
HXS70_08335	ENOG4108UH4	Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity)
HXS70_08345	ENOG4108R99	pseudouridine synthase
HXS70_08355	ENOG4108UGX	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity)
HXS70_08365	ENOG4105CKK	Glycosyl transferase, family 2
HXS70_08375	ENOG4105D7Q	type ii secretion system
HXS70_08380	ENOG4107QHF	type ii secretion system protein e
HXS70_08385	ENOG4107QHF	type ii secretion system protein e
HXS70_08390	ENOG4105CEH	Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity)
HXS70_08405	ENOG4105CJR	Integral membrane protein (MviN
HXS70_08410	ENOG4105DW0	Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity)
HXS70_08420	ENOG4105F32	YngK protein
HXS70_08425	ENOG4105DTC	1-(5-phosphoribosyl)-5-amino-4-imidazole-carboxylate (air) carboxylase
HXS70_08430	ENOG4105DVM	PP-loop domain protein
HXS70_08435	ENOG4105C8M	UPF0272 protein
HXS70_08440	ENOG4105EAH	synthase
HXS70_08455	ENOG4105VG1	fes assembly suf system protein
HXS70_08475	ENOG4105CNR	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
HXS70_08480	ENOG4105C8S	subunit m
HXS70_08495	ENOG4105M5H	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
HXS70_08500	ENOG4107UFS	subunit j
HXS70_08510	ENOG4105CMZ	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity)
HXS70_08515	ENOG4108IEH	NADH dehydrogenase subunit g
HXS70_08520	ENOG4107EEP	NADH dehydrogenase (quinone) (EC 1.6.99.5)
HXS70_08525	ENOG4105GKE	subunit e
HXS70_08530	ENOG4105CQV	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
HXS70_08540	ENOG4107BJW	polysaccharide deacetylase
HXS70_08550	ENOG4108R6K	riboflavin synthase, subunit alpha
HXS70_08555	ENOG4105F59	Methylates ribosomal protein L11 (By similarity)
HXS70_08565	ENOG4107S1W	4-alpha-glucanotransferase
HXS70_08575	ENOG4105CBM	Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity)
HXS70_08580	ENOG4105F7J	membrane-bound serine protease
HXS70_08585	ENOG4105C9G	DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity)
HXS70_08590	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
HXS70_08595	ENOG4108UQS	dipeptidase
HXS70_08610	ENOG4105C65	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity)
HXS70_08615	ENOG4105CN1	protease
HXS70_08630	ENOG4105CQ7	ATP-dependent helicase
HXS70_08655	ENOG4105GVR	general secretion pathway protein D
HXS70_08670	ENOG4105CN0	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity)
HXS70_08690	ENOG4105FBT	Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity)
HXS70_08695	ENOG4107RAJ	Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity)
HXS70_08705	ENOG410872P	Binds directly to 16S ribosomal RNA (By similarity)
HXS70_08710	ENOG4107VXZ	Hydrolase
HXS70_08715	ENOG4105C7K	acetolactate synthase
HXS70_08725	ENOG4105DJ4	phosphatidylserine decarboxylase
HXS70_08735	ENOG4105C8T	Leucyl-tRNA synthetase
HXS70_08740	ENOG4105ENH	Sulfatase
HXS70_08755	ENOG4105DP5	Catalyzes the biosynthesis of agmatine from arginine (By similarity)
HXS70_08770	ENOG4105CNT	hydrolase family 2
HXS70_08775	ENOG4105CNT	hydrolase family 2
HXS70_08780	ENOG4105CNT	hydrolase family 2
HXS70_08785	ENOG4105D1H	recombination factor protein RarA
HXS70_08790	ENOG4105E2D	ec 3.2.1.52
HXS70_08800	ENOG4105CTQ	phosphohexokinase
HXS70_08820	ENOG4105EZY	Pyrroloquinoline quinone biosynthesis protein E
HXS70_08850	ENOG4108YZT	Adenosylcobinamide kinase
HXS70_08865	ENOG4105CUP	Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity)
HXS70_08870	ENOG4105DH2	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity)
HXS70_08875	ENOG4105CAA	catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity)
HXS70_08880	ENOG4107ENK	receptor
HXS70_08900	ENOG4107SYB	Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity)
HXS70_08905	ENOG4107QN2	dihydrolipoyl dehydrogenase
HXS70_08925	ENOG4105CFY	cytochrome d ubiquinol oxidase, subunit ii
HXS70_08930	ENOG4105C4M	(Ubiquinol oxidase) subunit I
HXS70_08940	ENOG4107WAU	Protein tyrosine phosphatase
HXS70_08960	ENOG410834F	Transcriptional regulator
HXS70_08990	ENOG4108UB4	uncharacterized protein ygjQ
HXS70_09015	ENOG4105C9U	ATP-dependent DNA helicase RecQ
HXS70_09030	ENOG4105CH8	Succinyl-CoA ligase ADP-forming subunit alpha
HXS70_09035	ENOG4105CMV	Succinyl-CoA synthetase subunit beta
HXS70_09070	ENOG4105DVS	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity)
HXS70_09075	ENOG4105CEY	Amp-dependent synthetase and ligase
HXS70_09095	ENOG4108IAJ	Nad-dependent epimerase dehydratase
HXS70_09100	ENOG41065SU	Two-component system sensor kinase
HXS70_09115	ENOG4105D52	delta-aminolevulinic acid dehydratase
HXS70_09125	ENOG4105C22	threonyL-tRNA synthetase
HXS70_09130	ENOG4108UUX	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity)
HXS70_09140	ENOG4105CEA	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity)
HXS70_09165	ENOG4107R6G	Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity)
HXS70_09180	ENOG4105KPE	licD family
HXS70_09185	ENOG4107ZIC	Glycerol-3-phosphate cytidylyltransferase
HXS70_09195	ENOG4105KPE	licD family
HXS70_09200	ENOG4107YSK	Glycerol-3-phosphate cytidylyltransferase
HXS70_09215	ENOG4105KPE	licD family
HXS70_09230	ENOG4105P9C	Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity)
HXS70_09235	ENOG4105DBV	ornithine carbamoyltransferase
HXS70_09240	ENOG4107QRH	Arylsulfatase (Ec 3.1.6.1)
HXS70_09245	ENOG4105BZ3	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity)
HXS70_09250	ENOG41080Z8	PHOSPHOCARRIER protein
HXS70_09255	ENOG4105D1C	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity)
HXS70_09260	ENOG4105C9Y	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity)
HXS70_09265	ENOG4105DA5	(ABC) transporter
HXS70_09295	ENOG4105CND	Glycosyl transferase, family 2
HXS70_09315	ENOG4105FBQ	ATPase associated with various cellular activities aaa_5
HXS70_09315	ENOG4105FBQ	ATPase associated with various cellular activities aaa_5
HXS70_09330	ENOG4108ZB6	transcriptional regulator AsnC family
HXS70_09335	ENOG4105CHM	Aminotransferase
HXS70_09350	ENOG4105D9H	Catalyzes the attachment of glycine to tRNA(Gly) (By similarity)
HXS70_09355	ENOG4105CV8	reductase
HXS70_09370	ENOG4107QVM	von Willebrand factor, type A
HXS70_09385	ENOG4105C7R	Atpase associated with various cellular activities aaa_3
HXS70_09390	ENOG4105C3P	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity)
HXS70_09395	ENOG41081AP	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
HXS70_09435	ENOG4105C0H	protease
HXS70_09505	ENOG4105C87	Aminotransferase class I and II
HXS70_09515	ENOG4105CV8	reductase
HXS70_09520	ENOG4105ENX	hydrolase
HXS70_09525	ENOG4107SET	aldo keto reductase
HXS70_09530	ENOG4105DIN	metallophosphoesterase
HXS70_09550	ENOG4108MXQ	glutathione-regulated potassium-efflux system ancillary protein KefF
HXS70_09555	ENOG4105VUF	Transcriptional regulator
HXS70_09570	ENOG4105C3S	Mate efflux family protein
HXS70_09580	ENOG4105E2D	ec 3.2.1.52
HXS70_09595	ENOG4105DBZ	Dtdp-4-dehydrorhamnose reductase
HXS70_09610	ENOG4105VB6	UPF0109 protein
HXS70_09615	ENOG4105DR4	Methyltransferase
HXS70_09620	ENOG4105CKA	Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity)
HXS70_09635	ENOG4105DX0	Hemolysin A
HXS70_09655	ENOG4105C2I	pirin domain protein
HXS70_09680	ENOG4105CMG	Carbohydrate kinase
HXS70_09690	ENOG4105EHF	Converts the aldose L-fucose into the corresponding ketose L-fuculose (By similarity)
HXS70_09695	ENOG4105EDR	glucose galactose transporter
HXS70_09725	ENOG4105CBF	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity)
HXS70_09745	ENOG4105C0H	protease
HXS70_09760	ENOG4105E3B	Multicopper oxidase
HXS70_09765	ENOG4105EMK	carboxylate amino acid amine transporter
HXS70_09775	ENOG4105CJ4	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity)
HXS70_09780	ENOG4108JQ7	(ABC) transporter
HXS70_09790	ENOG4108J59	Extracellular solute-binding protein, family 5
HXS70_09795	ENOG4108IYQ	Binding-protein-dependent transport systems inner membrane component
HXS70_09815	ENOG41084M5	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity)
HXS70_09820	ENOG4105CKU	formyltetrahydrofolate synthetase
HXS70_09825	ENOG4108XC3	NADH ubiquinone oxidoreductase
HXS70_09830	ENOG4107QNG	Phosphoribosylglycinamide synthetase
HXS70_09855	ENOG4108Z02	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity)
HXS70_09890	ENOG4105D6P	C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex (By similarity)
HXS70_09900	ENOG4105NQN	cytochrome C
HXS70_09915	ENOG4105MEV	Acyl-transferase
HXS70_09920	ENOG4108HMX	isocitrate dehydrogenase (NADP)
HXS70_09935	ENOG4105CY0	Metallo-Beta-Lactamase
HXS70_09940	ENOG4108ZMD	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity)
HXS70_09945	ENOG4105FD2	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity)
HXS70_09955	ENOG4105D64	Mechanosensitive ion channel
HXS70_09965	ENOG410845M	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes (By similarity)
HXS70_09970	ENOG4105DWR	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity)
HXS70_09990	ENOG4105CMY	5-enolpyruvylshikimate-3-phosphate synthase
HXS70_10000	ENOG4105CDF	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity)
HXS70_10010	ENOG4105D10	5-enolpyruvylshikimate-3-phosphate phospholyase
HXS70_10020	ENOG4107EER	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity)
HXS70_10030	ENOG4105DIN	metallophosphoesterase
HXS70_10050	ENOG4105DVP	Adenine-specific
HXS70_10055	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
HXS70_10075	ENOG4108JB8	alcohol dehydrogenase
HXS70_10080	ENOG4105WMR	Protein CrcB homolog
HXS70_10090	ENOG4105C7C	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
HXS70_10105	ENOG4107RI4	Transfers the fatty acyl group on membrane lipoproteins (By similarity)
HXS70_10130	ENOG4105CRE	cytochrome C
HXS70_10145	ENOG4108IPW	abc transporter atp-binding protein
HXS70_10150	ENOG4105CM4	permease protein
HXS70_10155	ENOG4105DHS	permease protein
HXS70_10190	ENOG4105C2M	dna polymerase I
HXS70_10205	ENOG4105C83	adenylosuccinate lyase
HXS70_10210	ENOG4105D42	Cleaves the N-terminal amino acid of tripeptides (By similarity)
HXS70_10230	ENOG4105CDP	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity)
HXS70_10270	ENOG4108Z66	YbaK ebsC protein
HXS70_10315	ENOG4105C3R	Methionine synthase
HXS70_10320	ENOG4105DWK	Membrane
HXS70_10325	ENOG4107XM3	UPF0442 protein
HXS70_10340	ENOG4105CFH	Aspartokinase
HXS70_10360	ENOG4105BZH	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
HXS70_10365	ENOG4105E2X	shikimate dehydrogenase
HXS70_10375	ENOG4108R4Z	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity)
HXS70_10380	ENOG4108HRN	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity)
HXS70_10385	ENOG4107QP8	phosphohexose isomerase
HXS70_10395	ENOG4105DR4	Methyltransferase
HXS70_10405	ENOG4105D5P	Methylmalonyl-coA mutase
HXS70_10445	ENOG4108R3E	Dna-3-methyladenine glycosylase i
HXS70_10465	ENOG4105C0F	tryptophanase EC 4.1.99.1
HXS70_10480	ENOG4105C6A	phenylalanyl-tRNA synthetase (beta subunit)
HXS70_10500	ENOG4105CJX	Molecular chaperone. Has ATPase activity (By similarity)
HXS70_10530	ENOG4105WKZ	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease (By similarity)
HXS70_10545	ENOG4105CJ4	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity)
HXS70_10550	ENOG4108ZF1	Transcriptional regulator, BadM Rrf2 family
HXS70_10565	ENOG4108UV6	Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity)
HXS70_10570	ENOG4105C4U	4-methyl-5-beta-hydroxyethylthiazole kinase
HXS70_10585	ENOG4105E2D	ec 3.2.1.52
HXS70_10590	ENOG4105E2D	ec 3.2.1.52
HXS70_10595	ENOG4105DJT	lAO AO transport system ATPase
HXS70_10615	ENOG41081ID	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity)
HXS70_10620	ENOG4105C1J	atp-dependent rna helicase
HXS70_10625	ENOG4105C5X	domain protein
HXS70_10630	ENOG4105EKE	dihydroorotase
HXS70_10645	ENOG4105ENT	Efflux transporter rnd family, mfp subunit
HXS70_10655	ENOG4108YYV	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity)
HXS70_10665	ENOG4105CQX	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity)
HXS70_10670	ENOG4107QSA	Oxaloacetate decarboxylase
HXS70_10680	ENOG4107QI1	Mate efflux family protein
HXS70_10700	ENOG4105DGW	oligopeptidase A
HXS70_10705	ENOG4105ENT	Efflux transporter rnd family, mfp subunit
HXS70_10715	ENOG4105ENJ	RND efflux system, outer membrane lipoprotein
HXS70_10735	ENOG4105U6W	MutT NUDIX family protein
HXS70_10760	ENOG4105D82	Glutamate dehydrogenase
HXS70_10765	ENOG4105D0V	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
HXS70_10770	ENOG4107T5V	SNARE associated Golgi
HXS70_11065	ENOG4105C26	Dehydrogenase
HXS70_11085	ENOG4105CH6	catalase
HXS70_11095	ENOG4105CRE	cytochrome C
HXS70_11100	ENOG4108RAC	Rubrerythrin
HXS70_11105	ENOG41068WN	
HXS70_11115	ENOG4105CNU	cell division protein FtsK
HXS70_11145	ENOG4108QV3	biosynthesis protein
HXS70_11155	ENOG4105D3Q	Sugar transferase
HXS70_11165	ENOG4107XU6	Glycosyl transferase (Group 1
HXS70_11175	ENOG4105E2K	Glycosyl transferase (Group 1
HXS70_11205	ENOG4105CPK	Glycosyl transferase (Group 1
HXS70_11215	ENOG4108Z90	colanic acid biosynthesis acetyltransferase wcaF
HXS70_11225	ENOG4105K64	Glycosyl transferase, family 2
HXS70_11230	ENOG4105K64	Glycosyl transferase, family 2
HXS70_11275	ENOG4105C87	Aminotransferase class I and II
HXS70_11285	ENOG4105C4A	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity)
HXS70_11290	ENOG4105C6K	Malic enzyme
HXS70_11305	ENOG4107QPA	Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides (By similarity)
HXS70_11325	ENOG4105CSA	Coproporphyrinogen iii oxidase
HXS70_11365	ENOG4105CGR	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity)
HXS70_11370	ENOG4105CPQ	Dehydrogenase
HXS70_11385	ENOG4105C7R	Atpase associated with various cellular activities aaa_3
HXS70_11395	ENOG4108ZPD	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity)
HXS70_11400	ENOG4105BZ4	penicillin-binding protein
HXS70_11415	ENOG4105C91	Plays an important role in the de novo pathway of purine nucleotide biosynthesis
HXS70_11430	ENOG4105E3S	small subunit
HXS70_11435	ENOG4105DPX	Hydrogenase, large subunit
HXS70_11445	ENOG4108USZ	hydrogenase
HXS70_11450	ENOG4105WMM	Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity)
HXS70_11475	ENOG4108RCM	Nitroreductase
HXS70_11480	ENOG4105CIH	Imidazole acetol-phosphate transaminase
HXS70_11500	ENOG4107QN8	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
HXS70_11510	ENOG4107GFK	fumarate
HXS70_11530	ENOG4107YVC	modification (methylase)
HXS70_11555	ENOG4105E2D	ec 3.2.1.52
HXS70_11565	ENOG4105D0I	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity)
HXS70_11620	ENOG4105ES3	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
HXS70_11625	ENOG4105CYU	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
HXS70_11640	ENOG4105CEY	Amp-dependent synthetase and ligase
HXS70_11670	ENOG4105DGW	oligopeptidase A
HXS70_11685	ENOG4105C75	arginyL-tRNA synthetase
HXS70_11730	ENOG4105C5U	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity)
HXS70_11735	ENOG4105CI6	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving
HXS70_11740	ENOG4107QZM	n-acetylglutamate synthase
HXS70_11750	ENOG4108YZ4	nudix hydrolase
HXS70_11755	ENOG4105CI4	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity)
HXS70_11760	ENOG4105CJ1	ABC, transporter
HXS70_11780	ENOG4107XF7	NGG1p interacting factor 3 protein, NIF3
HXS70_11800	ENOG4105C77	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity)
HXS70_11805	ENOG4105BZQ	cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase
HXS70_11810	ENOG4105C0D	helicase
HXS70_11850	ENOG4105EPC	oxidoreductase
HXS70_11870	ENOG4105DTW	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
HXS70_11880	ENOG4105JAB	phenazine biosynthesis protein, phzf family
HXS70_11885	ENOG4108UI1	Probably functions as a manganese efflux pump (By similarity)
HXS70_11910	ENOG4108IAJ	Nad-dependent epimerase dehydratase
HXS70_11935	ENOG4107QP0	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity)
HXS70_11970	ENOG4105E5D	amino acid
HXS70_11975	ENOG4105CSV	Glutaminase
HXS70_11985	ENOG4105BZG	amino acid carrier protein
HXS70_11995	ENOG4105C8K	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity)
HXS70_12000	ENOG4105EQY	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity)
HXS70_12005	ENOG4105C25	Primosomal protein n'
HXS70_12010	ENOG4105E4Z	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity)
HXS70_12025	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
HXS70_12030	ENOG4107QJQ	Mate efflux family protein
HXS70_12080	ENOG4105CYQ	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity)
HXS70_12085	ENOG4105C2R	Single-stranded-DNA-specific exonuclease (RecJ)
HXS70_12090	ENOG4105CPE	K01197 hyaluronoglucosaminidase EC 3.2.1.35
HXS70_12110	ENOG4105DIK	(ABC) transporter
HXS70_12115	ENOG4105CC5	ABC transporter
HXS70_12120	ENOG4108Z0C	Uvrb UvrC protein
HXS70_12125	ENOG41066A3	ATP guanido phosphotransferase
HXS70_12130	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
HXS70_12140	ENOG4105C72	UPF0176 protein
HXS70_12145	ENOG4105ERH	Fumarylacetoacetate hydrolase
HXS70_12150	ENOG4105CYQ	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity)
HXS70_12165	ENOG4108UH8	Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity)
HXS70_12175	ENOG4105C31	Tryptophanyl-tRNA synthetase
HXS70_12185	ENOG4105D48	metallophosphoesterase
HXS70_12190	ENOG4105CUZ	uba thif-type nad fad binding protein
HXS70_12205	ENOG4105D7K	pfkb domain protein
HXS70_12210	ENOG4105E09	nadh pyrophosphatase
HXS70_12215	ENOG4107EEK	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity)
HXS70_12235	ENOG4107WDG	serine threonine protein kinase
HXS70_12490	ENOG4105DC6	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity)
HXS70_12505	ENOG4105K78	MarR family Transcriptional regulator
HXS70_12515	ENOG4105D6W	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity)
HXS70_12520	ENOG4105C7E	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity)
HXS70_12530	ENOG4105DZA	Converts GTP to 7,8-dihydroneopterin triphosphate (By similarity)
HXS70_12535	ENOG4105VH8	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity)
HXS70_12540	ENOG41083ND	50S ribosomal protein L33
HXS70_12545	ENOG4105SCY	DNAK suppressor
HXS70_12550	ENOG4105DKQ	ROK family
HXS70_12555	ENOG4105CYJ	ribosomal RNA small subunit methyltransferase B
HXS70_12565	ENOG4105M6F	mutator MutT protein
HXS70_12570	ENOG4105CW7	secretion protein, HlyD family
HXS70_12575	ENOG4108EE5	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
HXS70_12580	ENOG4108EE5	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
HXS70_12600	ENOG4105C1P	efflux transporter, rnd family, mfp subunit
HXS70_12610	ENOG4108R96	Methyltransferase, YaeB family
HXS70_12615	ENOG4105CD3	dihydroorotase
HXS70_12620	ENOG4105CXT	aspartate transcarbamylase
HXS70_12625	ENOG4108UK1	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity)
HXS70_12645	ENOG4105DZ0	fad dependent oxidoreductase
HXS70_12650	ENOG4105DWY	Agmatine deiminase
HXS70_12665	ENOG41061MV	Arylsulfatase
HXS70_12675	ENOG4105CE1	Ferrous iron transport protein b
HXS70_12700	ENOG4105DF5	DNA topoisomerase IV, subunit A
HXS70_12725	ENOG4105FA0	parb-like partition protein
HXS70_12755	ENOG4105DHU	Bile acid
HXS70_12760	ENOG4105DA0	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity)
HXS70_12775	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
HXS70_12780	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
HXS70_12785	ENOG4107QSI	ABC, transporter
HXS70_12820	ENOG4105CDK	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity)
HXS70_12825	ENOG4105CIT	This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity)
HXS70_12840	ENOG4105BZ1	(ABC) transporter
HXS70_12845	ENOG4105BZ1	(ABC) transporter
HXS70_12860	ENOG4105DHJ	ABC, transporter
HXS70_12865	ENOG4107PE3	Mammalian cell entry related domain protein
HXS70_12885	ENOG4105CZX	twitching motility protein
HXS70_12890	ENOG4105CZX	twitching motility protein
HXS70_12895	ENOG4105DBD	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity)
HXS70_12910	ENOG4105CET	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity)
HXS70_12915	ENOG4105C8D	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity)
HXS70_12920	ENOG4107RJ1	sodium solute
HXS70_12950	ENOG4105C0H	protease
HXS70_12965	ENOG4108JQC	penicillin-binding protein 1A
HXS70_12975	ENOG4108JQC	penicillin-binding protein 1A
HXS70_12980	ENOG4108JQC	penicillin-binding protein 1A
HXS70_12990	ENOG4105CGY	Dna recombination protein
HXS70_12995	ENOG4105CGY	Dna recombination protein