locus-tag	class	description
HXS70_00020	COG1127	ABC transporter
HXS70_00050	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HXS70_00080	COG0504	CTP synthase activity
HXS70_00085	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HXS70_00110	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HXS70_00120	COG1322	Protein conserved in bacteria
HXS70_00125	COG0546	phosphoglycolate phosphatase activity
HXS70_00130	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HXS70_00140	COG4591	ABC-type transport system involved in lipoprotein release permease component
HXS70_00140	COG4591	ABC-type transport system involved in lipoprotein release permease component
HXS70_00145	COG4104	PAAR repeat-containing protein
HXS70_00145	COG3209	COG3209 Rhs family protein
HXS70_00165	COG3209	COG3209 Rhs family protein
HXS70_00175	COG3209	COG3209 Rhs family protein
HXS70_00220	COG2234	aminopeptidase activity
HXS70_00225	COG2755	lipolytic protein G-D-S-L family
HXS70_00225	COG0657	acetylesterase activity
HXS70_00230	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HXS70_00250	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HXS70_00265	COG0335	large ribosomal subunit rRNA binding
HXS70_00275	COG0346	lactoylglutathione lyase activity
HXS70_00290	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
HXS70_00295	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
HXS70_00305	COG0427	acetyl-CoA hydrolase
HXS70_00315	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
HXS70_00325	COG0205	6-phosphofructokinase activity
HXS70_00335	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HXS70_00340	COG0028	Belongs to the TPP enzyme family
HXS70_00360	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HXS70_00375	COG0471	metal ion transport
HXS70_00385	COG0351	phosphomethylpyrimidine kinase
HXS70_00440	COG1028	Short-chain dehydrogenase reductase Sdr
HXS70_00450	COG0242	peptide deformylase activity
HXS70_00455	COG1063	alcohol dehydrogenase
HXS70_00465	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HXS70_00470	COG1393	Belongs to the ArsC family
HXS70_00475	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
HXS70_00485	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HXS70_00495	COG1187	pseudouridine synthase activity
HXS70_00505	COG0336	Belongs to the RNA methyltransferase TrmD family
HXS70_00510	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HXS70_00520	COG0539	negative regulation of cytoplasmic translation
HXS70_00610	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HXS70_00615	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HXS70_00620	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HXS70_00625	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HXS70_00660	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HXS70_00680	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HXS70_00680	COG0662	Cupin 2, conserved barrel domain protein
HXS70_00690	COG0416	fatty acid biosynthetic process
HXS70_00695	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HXS70_00705	COG0537	adenosine 5'-monophosphoramidase activity
HXS70_00710	COG0009	L-threonylcarbamoyladenylate synthase
HXS70_00715	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HXS70_00720	COG0228	four-way junction DNA binding
HXS70_00740	COG1862	Preprotein translocase
HXS70_00745	COG0343	queuine tRNA-ribosyltransferase activity
HXS70_00750	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HXS70_00760	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HXS70_00765	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HXS70_00770	COG0776	regulation of translation
HXS70_00800	COG0811	peptide transport
HXS70_00815	COG3250	beta-galactosidase activity
HXS70_00820	COG0525	valine-tRNA ligase activity
HXS70_00830	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HXS70_00835	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HXS70_00840	COG0255	Belongs to the universal ribosomal protein uL29 family
HXS70_00845	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HXS70_00850	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HXS70_00855	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HXS70_00865	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HXS70_00870	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HXS70_00875	COG0089	rRNA binding
HXS70_00880	COG0088	Forms part of the polypeptide exit tunnel
HXS70_00885	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HXS70_00890	COG0051	transcription antitermination factor activity, RNA binding
HXS70_00895	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HXS70_00900	COG0049	tRNA binding
HXS70_00905	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HXS70_00920	COG3852	Histidine kinase
HXS70_00935	COG1722	exodeoxyribonuclease VII activity
HXS70_00940	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HXS70_00955	COG0795	lipopolysaccharide-transporting ATPase activity
HXS70_00960	COG1160	GTP binding
HXS70_00965	COG0444	Belongs to the ABC transporter superfamily
HXS70_00980	COG1136	(ABC) transporter
HXS70_00980	COG0577	efflux transmembrane transporter activity
HXS70_00990	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HXS70_01035	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HXS70_01085	COG0799	negative regulation of ribosome biogenesis
HXS70_01090	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HXS70_01140	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
HXS70_01155	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HXS70_01165	COG4221	oxidoreductase activity
HXS70_01190	COG0038	chloride channel
HXS70_01200	COG3525	Glycosyl hydrolase, family 20, catalytic domain
HXS70_01215	COG0076	glutamate decarboxylase activity
HXS70_01230	COG0167	dihydroorotate dehydrogenase activity
HXS70_01235	COG0352	thiamine-phosphate diphosphorylase activity
HXS70_01255	COG1253	flavin adenine dinucleotide binding
HXS70_01260	COG1253	flavin adenine dinucleotide binding
HXS70_01265	COG1185	polyribonucleotide nucleotidyltransferase activity
HXS70_01270	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HXS70_01300	COG0101	tRNA pseudouridine synthase activity
HXS70_01305	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HXS70_01320	COG4968	Prepilin-type N-terminal cleavage methylation domain
HXS70_01340	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HXS70_01360	COG1136	(ABC) transporter
HXS70_01365	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HXS70_01375	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HXS70_01385	COG1116	anion transmembrane transporter activity
HXS70_01400	COG3525	Glycosyl hydrolase, family 20, catalytic domain
HXS70_01405	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HXS70_01410	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
HXS70_01420	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HXS70_01425	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HXS70_01435	COG2814	Major facilitator Superfamily
HXS70_01450	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HXS70_01455	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HXS70_01455	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HXS70_01460	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HXS70_01465	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HXS70_01470	COG0552	protein localization to endoplasmic reticulum
HXS70_01475	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HXS70_01495	COG1058	Belongs to the CinA family
HXS70_01495	COG1546	Belongs to the CinA family
HXS70_01505	COG0456	acetyltransferase
HXS70_01530	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HXS70_01535	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HXS70_01540	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HXS70_01545	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HXS70_01560	COG0758	DNA mediated transformation
HXS70_01565	COG1686	Belongs to the peptidase S11 family
HXS70_01570	COG0012	GTP binding
HXS70_01575	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HXS70_01585	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HXS70_01585	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HXS70_01600	COG3119	arylsulfatase activity
HXS70_01625	COG2259	Doxx family
HXS70_01630	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HXS70_01660	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HXS70_01680	COG2326	polyphosphate kinase activity
HXS70_01685	COG1349	DNA-binding transcription factor activity
HXS70_01705	COG1104	cysteine desulfurase activity
HXS70_01715	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HXS70_01720	COG1162	GTPase activity
HXS70_01735	COG0742	ribosomal rna small subunit methyltransferase
HXS70_01750	COG2326	polyphosphate kinase activity
HXS70_01760	COG5434	Belongs to the glycosyl hydrolase 28 family
HXS70_01765	COG5434	Belongs to the glycosyl hydrolase 28 family
HXS70_01775	COG1073	alpha beta
HXS70_01780	COG0802	atpase or kinase
HXS70_01785	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HXS70_01790	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HXS70_01795	COG0735	belongs to the Fur family
HXS70_01800	COG0396	ATPase activity
HXS70_01805	COG0719	Fe-S assembly protein
HXS70_01830	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HXS70_01875	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HXS70_01895	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HXS70_01900	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HXS70_01905	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HXS70_01910	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HXS70_01915	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HXS70_01920	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HXS70_01930	COG0356	it plays a direct role in the translocation of protons across the membrane
HXS70_01980	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HXS70_02015	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HXS70_02020	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HXS70_02035	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HXS70_02045	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HXS70_02050	COG0047	phosphoribosylformylglycinamidine synthase activity
HXS70_02060	COG1363	Peptidase, m42
HXS70_02075	COG1077	Cell shape determining protein MreB Mrl
HXS70_02080	COG1530	ribonuclease E activity
HXS70_02100	COG0848	biopolymer transport protein
HXS70_02115	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HXS70_02130	COG0134	indole-3-glycerol-phosphate synthase activity
HXS70_02135	COG0792	nuclease activity
HXS70_02145	COG1253	flavin adenine dinucleotide binding
HXS70_02155	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HXS70_02160	COG0137	argininosuccinate synthase activity
HXS70_02175	COG0149	triose-phosphate isomerase activity
HXS70_02180	COG4968	Prepilin-type N-terminal cleavage methylation domain
HXS70_02205	COG1040	competence protein
HXS70_02215	COG3956	TIGRFAM MazG family protein
HXS70_02235	COG1663	tetraacyldisaccharide 4'-kinase activity
HXS70_02245	COG0612	Peptidase, M16
HXS70_02250	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HXS70_02255	COG0583	DNA-binding transcription factor activity
HXS70_02280	COG0673	inositol 2-dehydrogenase activity
HXS70_02285	COG3034	peptidoglycan biosynthetic process
HXS70_02305	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HXS70_02310	COG0424	maF-like protein
HXS70_02315	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HXS70_02345	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HXS70_02355	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HXS70_02365	COG0571	ribonuclease III activity
HXS70_02385	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HXS70_02400	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HXS70_02420	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HXS70_02435	COG2226	methyltransferase
HXS70_02445	COG2076	Multidrug Resistance protein
HXS70_02620	COG1783	phage Terminase large subunit
HXS70_02730	COG2255	four-way junction helicase activity
HXS70_02735	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HXS70_02740	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HXS70_02745	COG1215	transferase activity, transferring glycosyl groups
HXS70_02755	COG0017	Asparaginyl-tRNA synthetase
HXS70_02765	COG3118	belongs to the thioredoxin family
HXS70_02810	COG0583	DNA-binding transcription factor activity
HXS70_02815	COG2855	membrane
HXS70_02820	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HXS70_02830	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HXS70_02840	COG0602	queuosine metabolic process
HXS70_02845	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HXS70_02850	COG0217	transcriptional regulatory protein
HXS70_02855	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HXS70_02860	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HXS70_02860	COG4651	solute:proton antiporter activity
HXS70_02870	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HXS70_02875	COG4864	UPF0365 protein
HXS70_02885	COG2022	thiamine diphosphate biosynthetic process
HXS70_02890	COG0531	amino acid
HXS70_02900	COG0628	permease
HXS70_02905	COG0019	diaminopimelate decarboxylase activity
HXS70_02910	COG0191	fructose-bisphosphate aldolase activity
HXS70_02945	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HXS70_02955	COG1181	Belongs to the D-alanine--D-alanine ligase family
HXS70_03035	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HXS70_03040	COG0517	IMP dehydrogenase activity
HXS70_03040	COG0516	GMP reductase activity
HXS70_03055	COG0546	phosphoglycolate phosphatase activity
HXS70_03080	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HXS70_03095	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
HXS70_03100	COG0196	riboflavin kinase activity
HXS70_03105	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HXS70_03115	COG1408	metallophosphoesterase
HXS70_03125	COG1442	glycosyl transferase family 8
HXS70_03125	COG1216	Glycosyl transferase, family 2
HXS70_03135	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HXS70_03140	COG1216	Glycosyl transferase, family 2
HXS70_03160	COG2755	lipolytic protein G-D-S-L family
HXS70_03160	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HXS70_03175	COG0490	domain, Protein
HXS70_03175	COG0471	metal ion transport
HXS70_03210	COG0588	phosphoglycerate mutase activity
HXS70_03215	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HXS70_03225	COG0477	Major facilitator Superfamily
HXS70_03230	COG1607	acyl-coa hydrolase
HXS70_03240	COG1028	Short-chain dehydrogenase reductase Sdr
HXS70_03250	COG1525	nuclease
HXS70_03260	COG1475	DNA binding
HXS70_03265	COG3969	phosphoadenosine phosphosulfate
HXS70_03420	COG0305	Participates in initiation and elongation during chromosome replication
HXS70_03530	COG0473	3-isopropylmalate dehydrogenase activity
HXS70_03555	COG2873	o-acetylhomoserine
HXS70_03565	COG0535	radical SAM domain protein
HXS70_03580	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HXS70_03585	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HXS70_03595	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HXS70_03605	COG0674	pyruvate-flavodoxin oxidoreductase activity
HXS70_03605	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
HXS70_03605	COG1013	pyruvate-flavodoxin oxidoreductase activity
HXS70_03605	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HXS70_03615	COG1733	regulation of RNA biosynthetic process
HXS70_03625	COG0107	imidazoleglycerol-phosphate synthase activity
HXS70_03630	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HXS70_03640	COG1643	Atp-dependent helicase
HXS70_03645	COG0440	acetolactate synthase activity
HXS70_03650	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HXS70_03660	COG0445	tRNA wobble uridine modification
HXS70_03665	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HXS70_03665	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HXS70_03670	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HXS70_03680	COG0592	DNA-directed DNA polymerase activity
HXS70_03735	COG0791	NLP P60 protein
HXS70_03735	COG1388	LysM domain
HXS70_03740	COG0084	hydrolase, TatD family'
HXS70_03750	COG3250	beta-galactosidase activity
HXS70_03765	COG2205	protein histidine kinase activity
HXS70_03770	COG0745	RESPONSE REGULATOR receiver
HXS70_03780	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
HXS70_03805	COG0542	response to heat
HXS70_03850	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HXS70_03860	COG0659	secondary active sulfate transmembrane transporter activity
HXS70_03865	COG0165	Argininosuccinate lyase
HXS70_03880	COG0148	phosphopyruvate hydratase activity
HXS70_03885	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
HXS70_03910	COG3481	metal-dependent phosphohydrolase, HD sub domain
HXS70_03920	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HXS70_03925	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HXS70_03950	COG3345	alpha-galactosidase
HXS70_03980	COG2985	domain, Protein
HXS70_03980	COG0490	domain, Protein
HXS70_03995	COG0471	metal ion transport
HXS70_04020	COG2194	sulfuric ester hydrolase activity
HXS70_04025	COG1592	Rubrerythrin
HXS70_04035	COG1363	Peptidase, m42
HXS70_04040	COG3525	Glycosyl hydrolase, family 20, catalytic domain
HXS70_04050	COG1785	Belongs to the alkaline phosphatase family
HXS70_04055	COG1970	mechanosensitive ion channel activity
HXS70_04060	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HXS70_04080	COG2217	Heavy metal translocating P-type atpase
HXS70_04085	COG0497	DNA recombination
HXS70_04090	COG0321	lipoyl(octanoyl) transferase activity
HXS70_04090	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HXS70_04095	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
HXS70_04130	COG0508	dehydrogenase complex catalyzes the overall conversion of
HXS70_04135	COG0022	dehydrogenase e1 component
HXS70_04140	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HXS70_04145	COG0789	Transcriptional regulator
HXS70_04150	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HXS70_04155	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HXS70_04160	COG3210	domain, Protein
HXS70_04210	COG3409	Peptidoglycan-binding domain 1 protein
HXS70_04210	COG5632	N-Acetylmuramoyl-L-alanine amidase
HXS70_04215	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HXS70_04245	COG1690	Belongs to the RtcB family
HXS70_04255	COG2814	Major facilitator Superfamily
HXS70_04265	COG2096	Adenosyltransferase
HXS70_04275	COG0557	exoribonuclease II activity
HXS70_04300	COG0826	peptidase U32
HXS70_04305	COG0285	dihydrofolate synthase activity
HXS70_04320	COG0673	inositol 2-dehydrogenase activity
HXS70_04325	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HXS70_04330	COG0737	Belongs to the 5'-nucleotidase family
HXS70_04340	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HXS70_04345	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HXS70_04360	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HXS70_04365	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HXS70_04370	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HXS70_04375	COG0200	Binds to the 23S rRNA
HXS70_04380	COG0201	protein transport
HXS70_04385	COG0563	adenylate kinase activity
HXS70_04390	COG0024	Methionine aminopeptidase
HXS70_04405	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HXS70_04410	COG1442	glycosyl transferase family 8
HXS70_04420	COG1216	Glycosyl transferase, family 2
HXS70_04430	COG1216	Glycosyl transferase, family 2
HXS70_04445	COG1216	Glycosyl transferase, family 2
HXS70_04450	COG0693	protein deglycase activity
HXS70_04455	COG0508	dehydrogenase complex catalyzes the overall conversion of
HXS70_04460	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HXS70_04465	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HXS70_04475	COG1966	Carbon starvation protein
HXS70_04485	COG3119	arylsulfatase activity
HXS70_04495	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HXS70_04500	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HXS70_04505	COG0195	Participates in both transcription termination and antitermination
HXS70_04510	COG0708	Exodeoxyribonuclease III
HXS70_04515	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HXS70_04520	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
HXS70_04525	COG2006	4fe-4S ferredoxin, iron-sulfur binding domain protein
HXS70_04535	COG1716	ATPase activity
HXS70_04535	COG1131	(ABC) transporter
HXS70_04535	COG0842	Transport permease protein
HXS70_04555	COG0724	RNA recognition motif
HXS70_04560	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HXS70_04580	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HXS70_04590	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
HXS70_04595	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HXS70_04610	COG1490	D-aminoacyl-tRNA deacylase activity
HXS70_04645	COG3209	COG3209 Rhs family protein
HXS70_04655	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HXS70_04660	COG1053	succinate dehydrogenase
HXS70_04690	COG1216	Glycosyl transferase, family 2
HXS70_04690	COG0463	Glycosyl transferase, family 2
HXS70_04725	COG0438	transferase activity, transferring glycosyl groups
HXS70_04735	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HXS70_04745	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HXS70_04775	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HXS70_04785	COG1137	ATPase activity
HXS70_04800	COG2877	3-deoxy-8-phosphooctulonate synthase activity
HXS70_04815	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HXS70_04825	COG4608	Belongs to the ABC transporter superfamily
HXS70_04830	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HXS70_04840	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HXS70_04850	COG0066	3-isopropylmalate dehydratase activity
HXS70_04855	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HXS70_04860	COG0321	lipoyl(octanoyl) transferase activity
HXS70_04865	COG0860	N-Acetylmuramoyl-L-alanine amidase
HXS70_04870	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HXS70_04880	COG1181	Belongs to the D-alanine--D-alanine ligase family
HXS70_04885	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HXS70_04890	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HXS70_04895	COG0772	Belongs to the SEDS family
HXS70_04905	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HXS70_04910	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HXS70_04915	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HXS70_04920	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HXS70_04925	COG0768	penicillin binding
HXS70_04930	COG0768	penicillin binding
HXS70_04940	COG0275	rRNA processing
HXS70_04945	COG2001	Belongs to the MraZ family
HXS70_04950	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
HXS70_04955	COG2860	membrane
HXS70_04965	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HXS70_04970	COG0482	sulfurtransferase activity
HXS70_04990	COG1028	Short-chain dehydrogenase reductase Sdr
HXS70_05000	COG0488	(ABC) transporter
HXS70_05010	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HXS70_05020	COG1253	flavin adenine dinucleotide binding
HXS70_05025	COG1028	Short-chain dehydrogenase reductase Sdr
HXS70_05035	COG1073	alpha beta
HXS70_05045	COG0667	Aldo Keto reductase
HXS70_05100	COG2267	carboxylic ester hydrolase activity
HXS70_05105	COG2095	MarC family integral membrane protein
HXS70_05145	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HXS70_05150	COG0488	(ABC) transporter
HXS70_05155	COG0697	spore germination
HXS70_05165	COG0215	cysteine-tRNA ligase activity
HXS70_05175	COG3119	arylsulfatase activity
HXS70_05185	COG0481	GTPase activity
HXS70_05205	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HXS70_05210	COG0085	RNA polymerase activity
HXS70_05215	COG0222	ribosome binding
HXS70_05220	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HXS70_05225	COG0081	regulation of translation
HXS70_05230	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HXS70_05235	COG0250	Participates in transcription elongation, termination and antitermination
HXS70_05250	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HXS70_05260	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HXS70_05270	COG0740	serine-type endopeptidase activity
HXS70_05275	COG0544	peptidyl-prolyl cis-trans isomerase activity
HXS70_05290	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HXS70_05310	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HXS70_05355	COG2226	methyltransferase
HXS70_05360	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HXS70_05365	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
HXS70_05380	COG1902	pentaerythritol trinitrate reductase activity
HXS70_05380	COG0446	pyridine nucleotide-disulphide oxidoreductase
HXS70_05390	COG3119	arylsulfatase activity
HXS70_05395	COG0514	ATP-dependent DNA helicase (RecQ)
HXS70_05415	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HXS70_05475	COG1858	cytochrome C peroxidase
HXS70_05480	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HXS70_05485	COG0590	tRNA wobble adenosine to inosine editing
HXS70_05490	COG1940	carbohydrate kinase activity
HXS70_05495	COG2217	Heavy metal translocating P-type atpase
HXS70_05500	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HXS70_05530	COG1363	Peptidase, m42
HXS70_05535	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HXS70_05545	COG0006	proline dipeptidase activity
HXS70_05550	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HXS70_05575	COG5002	protein histidine kinase activity
HXS70_05580	COG0745	RESPONSE REGULATOR receiver
HXS70_05585	COG0129	dihydroxy-acid dehydratase activity
HXS70_05640	COG1368	sulfuric ester hydrolase activity
HXS70_05675	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HXS70_05680	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HXS70_05700	COG0534	Mate efflux family protein
HXS70_05705	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HXS70_05720	COG1876	peptidase activity
HXS70_05865	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
HXS70_05870	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
HXS70_05875	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
HXS70_05885	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HXS70_05895	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HXS70_05905	COG0515	serine threonine protein kinase
HXS70_05915	COG0789	Transcriptional regulator
HXS70_05960	COG0714	Associated with various cellular activities
HXS70_05965	COG2311	Membrane
HXS70_05990	COG1090	epimerase
HXS70_06000	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HXS70_06005	COG1119	ATPase activity
HXS70_06010	COG2186	Transcriptional regulator
HXS70_06035	COG0148	phosphopyruvate hydratase activity
HXS70_06040	COG0436	Aminotransferase
HXS70_06045	COG1477	protein flavinylation
HXS70_06060	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HXS70_06070	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HXS70_06090	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HXS70_06100	COG1199	ATP-dependent helicase activity
HXS70_06105	COG1122	ATPase activity
HXS70_06130	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HXS70_06135	COG0598	Magnesium transport protein CorA
HXS70_06140	COG0359	binds to the 23S rRNA
HXS70_06145	COG0138	bifunctional purine biosynthesis protein purh
HXS70_06150	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HXS70_06155	COG0736	holo-[acyl-carrier-protein] synthase activity
HXS70_06165	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
HXS70_06170	COG3409	Peptidoglycan-binding domain 1 protein
HXS70_06170	COG5632	N-Acetylmuramoyl-L-alanine amidase
HXS70_06175	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HXS70_06185	COG0437	4 iron, 4 sulfur cluster binding
HXS70_06205	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HXS70_06265	COG0284	orotidine-5'-phosphate decarboxylase activity
HXS70_06285	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HXS70_06290	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HXS70_06310	COG2003	Belongs to the UPF0758 family
HXS70_06315	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HXS70_06315	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HXS70_06320	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HXS70_06325	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HXS70_06330	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HXS70_06335	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
HXS70_06340	COG0322	excinuclease ABC activity
HXS70_06345	COG0811	peptide transport
HXS70_06350	COG0848	biopolymer transport protein
HXS70_06360	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HXS70_06365	COG0483	inositol monophosphate 1-phosphatase activity
HXS70_06370	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HXS70_06450	COG1482	cell wall glycoprotein biosynthetic process
HXS70_06460	COG1757	Na H antiporter
HXS70_06465	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HXS70_06470	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
HXS70_06475	COG0505	Belongs to the CarA family
HXS70_06480	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HXS70_06490	COG0070	glutamate synthase
HXS70_06490	COG0067	glutamate synthase
HXS70_06490	COG0069	glutamate synthase activity
HXS70_06495	COG0706	membrane insertase activity
HXS70_06500	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HXS70_06510	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HXS70_06520	COG2755	lipolytic protein G-D-S-L family
HXS70_06520	COG0657	acetylesterase activity
HXS70_06535	COG0259	pyridoxamine-phosphate oxidase activity
HXS70_06550	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HXS70_06570	COG0492	ferredoxin-NADP+ reductase activity
HXS70_06570	COG3118	belongs to the thioredoxin family
HXS70_06625	COG1408	metallophosphoesterase
HXS70_06635	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HXS70_06640	COG0545	Peptidyl-prolyl cis-trans isomerase
HXS70_06655	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HXS70_06665	COG0826	peptidase U32
HXS70_06670	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HXS70_06690	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HXS70_06710	COG0529	Catalyzes the synthesis of activated sulfate
HXS70_06710	COG2895	sulfate adenylyltransferase (ATP) activity
HXS70_06720	COG0175	sulfate reduction
HXS70_06725	COG0175	sulfate reduction
HXS70_06745	COG0581	inorganic phosphate transmembrane transporter activity
HXS70_06750	COG0573	inorganic phosphate transmembrane transporter activity
HXS70_06760	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HXS70_06770	COG2017	converts alpha-aldose to the beta-anomer
HXS70_06785	COG0612	Peptidase, M16
HXS70_06795	COG0110	maltose O-acetyltransferase activity
HXS70_06820	COG0233	cytoplasmic translational termination
HXS70_06825	COG0528	UMP kinase activity
HXS70_06830	COG0668	transmembrane transport
HXS70_06835	COG0450	alkyl hydroperoxide reductase
HXS70_06840	COG0733	neurotransmitter:sodium symporter activity
HXS70_06855	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HXS70_06865	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HXS70_06870	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HXS70_06875	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HXS70_07115	COG0305	Participates in initiation and elongation during chromosome replication
HXS70_07130	COG0842	Transport permease protein
HXS70_07135	COG0842	Transport permease protein
HXS70_07140	COG1131	(ABC) transporter
HXS70_07150	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HXS70_07155	COG1183	phosphatidylcholine synthase activity
HXS70_07165	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HXS70_07175	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HXS70_07180	COG1028	Short-chain dehydrogenase reductase Sdr
HXS70_07200	COG0156	8-amino-7-oxononanoate synthase activity
HXS70_07220	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HXS70_07225	COG0124	histidyl-tRNA synthetase
HXS70_07230	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HXS70_07235	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
HXS70_07240	COG0298	carbon dioxide binding
HXS70_07265	COG0438	transferase activity, transferring glycosyl groups
HXS70_07270	COG0443	Heat shock 70 kDa protein
HXS70_07275	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HXS70_07280	COG0459	protein refolding
HXS70_07330	COG0632	four-way junction helicase activity
HXS70_07340	COG0126	phosphoglycerate kinase activity
HXS70_07350	COG1082	Xylose isomerase domain protein TIM barrel
HXS70_07355	COG0515	serine threonine protein kinase
HXS70_07355	COG2815	serine threonine protein kinase
HXS70_07365	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HXS70_07375	COG2271	Major facilitator Superfamily
HXS70_07390	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HXS70_07400	COG0037	tRNA processing
HXS70_07405	COG0254	rRNA binding
HXS70_07445	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HXS70_07450	COG0039	L-malate dehydrogenase activity
HXS70_07470	COG0778	Nitroreductase
HXS70_07475	COG0564	pseudouridine synthase activity
HXS70_07500	COG1126	abc transporter atp-binding protein
HXS70_07505	COG0765	amino acid transport
HXS70_07515	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HXS70_07520	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HXS70_07570	COG1872	DUF167
HXS70_07575	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HXS70_07580	COG0484	heat shock protein binding
HXS70_07585	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HXS70_07595	COG5434	Belongs to the glycosyl hydrolase 28 family
HXS70_07610	COG0277	FAD linked oxidase domain protein
HXS70_07635	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HXS70_07640	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HXS70_07650	COG0131	Imidazoleglycerol-phosphate dehydratase
HXS70_07655	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HXS70_07660	COG0360	Binds together with S18 to 16S ribosomal RNA
HXS70_07665	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HXS70_07680	COG1686	Belongs to the peptidase S11 family
HXS70_07685	COG0205	6-phosphofructokinase activity
HXS70_07695	COG0428	transporter
HXS70_07700	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HXS70_07720	COG3977	Valine--pyruvate aminotransferase
HXS70_07725	COG1561	YicC-like family, N-terminal region
HXS70_07735	COG3273	potassium ion transport
HXS70_07735	COG0471	metal ion transport
HXS70_07740	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HXS70_07755	COG1575	Belongs to the MenA family. Type 1 subfamily
HXS70_07790	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HXS70_07790	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HXS70_07810	COG0202	RNA polymerase activity
HXS70_07815	COG0203	ribosomal protein L17
HXS70_07820	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HXS70_07830	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HXS70_07845	COG2885	chlorophyll binding
HXS70_07880	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HXS70_07920	COG0667	Aldo Keto reductase
HXS70_07925	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
HXS70_07940	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HXS70_07945	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HXS70_07950	COG0134	indole-3-glycerol-phosphate synthase activity
HXS70_07955	COG0135	phosphoribosylanthranilate isomerase activity
HXS70_07960	COG0133	tryptophan synthase activity
HXS70_07965	COG0159	tryptophan synthase activity
HXS70_07980	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HXS70_07985	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HXS70_07995	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HXS70_08025	COG0561	phosphatase activity
HXS70_08030	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HXS70_08035	COG2223	nitrite transmembrane transporter activity
HXS70_08145	COG2314	TM2 domain
HXS70_08165	COG0515	serine threonine protein kinase
HXS70_08180	COG3177	Filamentation induced by cAMP protein fic
HXS70_08215	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HXS70_08220	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HXS70_08245	COG1074	ATP-dependent DNA helicase activity
HXS70_08255	COG0697	spore germination
HXS70_08265	COG1002	Type II restriction enzyme, methylase subunits
HXS70_08270	COG1061	Type III restriction enzyme res subunit
HXS70_08275	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HXS70_08280	COG2373	Large extracellular alpha-helical protein
HXS70_08285	COG1979	alcohol dehydrogenase
HXS70_08295	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HXS70_08320	COG0372	Belongs to the citrate synthase family
HXS70_08335	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HXS70_08345	COG1187	pseudouridine synthase activity
HXS70_08355	COG0105	UTP biosynthetic process
HXS70_08360	COG1215	transferase activity, transferring glycosyl groups
HXS70_08365	COG0463	Glycosyl transferase, family 2
HXS70_08375	COG1459	type II secretion system
HXS70_08380	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HXS70_08390	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HXS70_08405	COG0728	peptidoglycan biosynthetic process
HXS70_08410	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
HXS70_08410	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HXS70_08420	COG1649	PFAM Uncharacterised BCR, COG1649
HXS70_08425	COG1691	(AIR) carboxylase
HXS70_08430	COG1606	tRNA processing
HXS70_08435	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
HXS70_08440	COG0142	geranyltranstransferase activity
HXS70_08455	COG2151	metal-sulfur cluster biosynthetic enzyme
HXS70_08475	COG1007	ATP synthesis coupled electron transport
HXS70_08480	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HXS70_08495	COG0713	ATP synthesis coupled electron transport
HXS70_08500	COG0839	Belongs to the complex I subunit 6 family
HXS70_08510	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HXS70_08515	COG1034	ATP synthesis coupled electron transport
HXS70_08520	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
HXS70_08525	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
HXS70_08530	COG0649	NAD binding
HXS70_08540	COG0726	polysaccharide deacetylase
HXS70_08550	COG0307	riboflavin synthase, alpha
HXS70_08555	COG2264	protein methyltransferase activity
HXS70_08560	COG3210	domain, Protein
HXS70_08565	COG1640	4-alpha-glucanotransferase
HXS70_08575	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HXS70_08580	COG1030	water channel activity
HXS70_08585	COG0358	DNA primase activity
HXS70_08590	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HXS70_08595	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
HXS70_08610	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HXS70_08615	COG0793	Belongs to the peptidase S41A family
HXS70_08630	COG1643	Atp-dependent helicase
HXS70_08655	COG1450	Type ii and iii secretion system protein
HXS70_08670	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HXS70_08690	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HXS70_08695	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HXS70_08705	COG0268	Binds directly to 16S ribosomal RNA
HXS70_08710	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HXS70_08715	COG0028	Belongs to the TPP enzyme family
HXS70_08725	COG0688	phosphatidylethanolamine metabolic process
HXS70_08730	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HXS70_08735	COG0495	leucyl-tRNA aminoacylation
HXS70_08740	COG3119	arylsulfatase activity
HXS70_08755	COG1166	arginine decarboxylase activity
HXS70_08765	COG3250	beta-galactosidase activity
HXS70_08770	COG3250	beta-galactosidase activity
HXS70_08775	COG3250	beta-galactosidase activity
HXS70_08780	COG3250	beta-galactosidase activity
HXS70_08785	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HXS70_08790	COG3525	Glycosyl hydrolase, family 20, catalytic domain
HXS70_08800	COG0205	6-phosphofructokinase activity
HXS70_08820	COG0535	radical SAM domain protein
HXS70_08865	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
HXS70_08870	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
HXS70_08880	COG4771	TonB-dependent receptor
HXS70_08900	COG0402	S-adenosylhomocysteine deaminase activity
HXS70_08905	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HXS70_08925	COG1294	oxidase, subunit
HXS70_08930	COG1271	oxidase subunit
HXS70_08940	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HXS70_08960	COG1846	Transcriptional regulator
HXS70_08990	COG2949	membrane
HXS70_09015	COG0514	ATP-dependent DNA helicase (RecQ)
HXS70_09030	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HXS70_09035	COG0045	succinate-CoA ligase (ADP-forming) activity
HXS70_09040	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HXS70_09095	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HXS70_09100	COG2205	protein histidine kinase activity
HXS70_09115	COG0113	porphobilinogen synthase activity
HXS70_09125	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HXS70_09140	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HXS70_09165	COG4106	trans-aconitate 2-methyltransferase activity
HXS70_09180	COG3475	LICD family
HXS70_09185	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HXS70_09195	COG3475	LICD family
HXS70_09200	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HXS70_09210	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HXS70_09215	COG3475	LICD family
HXS70_09230	COG2166	iron-sulfur cluster assembly
HXS70_09235	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HXS70_09245	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HXS70_09250	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HXS70_09255	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
HXS70_09260	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HXS70_09265	COG1131	(ABC) transporter
HXS70_09295	COG1215	transferase activity, transferring glycosyl groups
HXS70_09315	COG1401	restriction endodeoxyribonuclease activity
HXS70_09315	COG1401	restriction endodeoxyribonuclease activity
HXS70_09330	COG1522	sequence-specific DNA binding
HXS70_09335	COG0436	Aminotransferase
HXS70_09350	COG0423	glycine-tRNA ligase activity
HXS70_09355	COG0656	L-ascorbic acid biosynthetic process
HXS70_09370	COG2304	oxidoreductase activity
HXS70_09385	COG0714	Associated with various cellular activities
HXS70_09390	COG0154	amidase activity
HXS70_09395	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HXS70_09435	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HXS70_09440	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HXS70_09505	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HXS70_09515	COG0656	L-ascorbic acid biosynthetic process
HXS70_09525	COG0667	Aldo Keto reductase
HXS70_09530	COG1408	metallophosphoesterase
HXS70_09550	COG2249	NAD(P)H dehydrogenase (quinone) activity
HXS70_09555	COG0789	Transcriptional regulator
HXS70_09570	COG0534	Mate efflux family protein
HXS70_09595	COG1091	dTDP-4-dehydrorhamnose reductase activity
HXS70_09610	COG1837	Belongs to the UPF0109 family
HXS70_09615	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HXS70_09620	COG0363	glucosamine-6-phosphate deaminase activity
HXS70_09635	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
HXS70_09655	COG1741	Belongs to the pirin family
HXS70_09680	COG1070	Carbohydrate kinase
HXS70_09695	COG0738	Major facilitator superfamily
HXS70_09710	COG1595	DNA-templated transcription, initiation
HXS70_09725	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
HXS70_09745	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HXS70_09755	COG0232	Belongs to the dGTPase family. Type 2 subfamily
HXS70_09760	COG2132	Multicopper oxidase
HXS70_09765	COG0697	spore germination
HXS70_09775	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HXS70_09780	COG4608	Belongs to the ABC transporter superfamily
HXS70_09785	COG0444	Belongs to the ABC transporter superfamily
HXS70_09790	COG4166	transmembrane transport
HXS70_09795	COG4239	(ABC) transporter, permease
HXS70_09800	COG0601	transmembrane transport
HXS70_09815	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HXS70_09820	COG2759	Belongs to the formate--tetrahydrofolate ligase family
HXS70_09825	COG3738	Protein conserved in bacteria
HXS70_09830	COG0151	Belongs to the GarS family
HXS70_09845	COG0811	peptide transport
HXS70_09855	COG0242	peptide deformylase activity
HXS70_09890	COG2010	Cytochrome c
HXS70_09900	COG3258	Cytochrome c
HXS70_09915	COG3274	enterobacterial common antigen metabolic process
HXS70_09920	COG0538	isocitrate dehydrogenase activity
HXS70_09935	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
HXS70_09940	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HXS70_09945	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HXS70_09955	COG0668	transmembrane transport
HXS70_09965	COG0805	protein transport
HXS70_09970	COG1968	undecaprenyl-diphosphatase activity
HXS70_09990	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HXS70_10000	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HXS70_10010	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HXS70_10020	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HXS70_10030	COG1408	metallophosphoesterase
HXS70_10055	COG4974	Belongs to the 'phage' integrase family
HXS70_10075	COG1454	alcohol dehydrogenase
HXS70_10080	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HXS70_10090	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
HXS70_10090	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HXS70_10095	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HXS70_10130	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HXS70_10140	COG4607	ABC-type enterochelin transport system periplasmic component
HXS70_10145	COG4604	ABC transporter, ATP-binding protein
HXS70_10150	COG4605	iron ion homeostasis
HXS70_10155	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HXS70_10190	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HXS70_10190	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HXS70_10205	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HXS70_10210	COG2195	Cleaves the N-terminal amino acid of tripeptides
HXS70_10230	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HXS70_10245	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HXS70_10270	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HXS70_10315	COG0646	methionine synthase
HXS70_10315	COG1410	methionine synthase
HXS70_10320	COG2966	Psort location CytoplasmicMembrane, score
HXS70_10325	COG3610	response to peptide
HXS70_10335	COG0460	homoserine dehydrogenase
HXS70_10340	COG0527	aspartate kinase activity
HXS70_10350	COG5522	Integral membrane protein (intg_mem_TP0381)
HXS70_10360	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HXS70_10365	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HXS70_10375	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
HXS70_10380	COG0574	Belongs to the PEP-utilizing enzyme family
HXS70_10380	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HXS70_10385	COG0166	Belongs to the GPI family
HXS70_10395	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HXS70_10405	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HXS70_10405	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HXS70_10440	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HXS70_10445	COG2818	Glycosylase
HXS70_10465	COG3033	Beta-eliminating lyase
HXS70_10480	COG0072	phenylalanine-tRNA ligase activity
HXS70_10480	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HXS70_10500	COG0326	Molecular chaperone. Has ATPase activity
HXS70_10505	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HXS70_10530	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
HXS70_10545	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HXS70_10550	COG1959	2 iron, 2 sulfur cluster binding
HXS70_10565	COG0352	thiamine-phosphate diphosphorylase activity
HXS70_10570	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
HXS70_10595	COG1703	isobutyryl-CoA mutase activity
HXS70_10615	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
HXS70_10625	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HXS70_10630	COG0418	dihydroorotase activity
HXS70_10645	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HXS70_10665	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HXS70_10680	COG0534	Mate efflux family protein
HXS70_10685	COG0489	protein tyrosine kinase activity
HXS70_10705	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HXS70_10735	COG4112	unkown
HXS70_10750	COG0038	chloride channel
HXS70_10760	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HXS70_10765	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HXS70_10770	COG0586	Pfam SNARE associated Golgi protein
HXS70_11065	COG0506	proline dehydrogenase activity
HXS70_11065	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HXS70_11065	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HXS70_11085	COG0753	catalase activity
HXS70_11095	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HXS70_11100	COG1592	Rubrerythrin
HXS70_11105	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HXS70_11115	COG1674	ftsk spoiiie
HXS70_11145	COG0489	protein tyrosine kinase activity
HXS70_11155	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HXS70_11165	COG0438	transferase activity, transferring glycosyl groups
HXS70_11175	COG0438	transferase activity, transferring glycosyl groups
HXS70_11205	COG0438	transferase activity, transferring glycosyl groups
HXS70_11215	COG0110	maltose O-acetyltransferase activity
HXS70_11225	COG1216	Glycosyl transferase, family 2
HXS70_11230	COG1216	Glycosyl transferase, family 2
HXS70_11275	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HXS70_11280	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HXS70_11280	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HXS70_11285	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
HXS70_11290	COG0280	phosphate acetyltransferase
HXS70_11290	COG0281	malic enzyme
HXS70_11305	COG1472	Belongs to the glycosyl hydrolase 3 family
HXS70_11310	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HXS70_11325	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HXS70_11365	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HXS70_11370	COG1063	alcohol dehydrogenase
HXS70_11385	COG0714	Associated with various cellular activities
HXS70_11395	COG0193	aminoacyl-tRNA hydrolase activity
HXS70_11400	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HXS70_11415	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HXS70_11435	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
HXS70_11450	COG0375	protein maturation
HXS70_11475	COG0778	Nitroreductase
HXS70_11480	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HXS70_11500	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HXS70_11510	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HXS70_11510	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HXS70_11530	COG0863	Belongs to the N(4) N(6)-methyltransferase family
HXS70_11555	COG3525	Glycosyl hydrolase, family 20, catalytic domain
HXS70_11560	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HXS70_11565	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HXS70_11620	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HXS70_11625	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HXS70_11640	COG0318	PFAM AMP-dependent synthetase and ligase
HXS70_11670	COG0339	signal peptide processing
HXS70_11685	COG0018	arginyl-trna synthetase
HXS70_11730	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HXS70_11735	COG0653	protein targeting
HXS70_11750	COG0494	nUDIX hydrolase
HXS70_11755	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HXS70_11760	COG1131	(ABC) transporter
HXS70_11780	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HXS70_11785	COG0564	pseudouridine synthase activity
HXS70_11800	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HXS70_11805	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HXS70_11810	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HXS70_11850	COG0673	inositol 2-dehydrogenase activity
HXS70_11885	COG1971	Probably functions as a manganese efflux pump
HXS70_11910	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HXS70_11935	COG0442	prolyl-tRNA aminoacylation
HXS70_11970	COG0531	amino acid
HXS70_11975	COG2066	Belongs to the glutaminase family
HXS70_11985	COG1115	amino acid carrier protein
HXS70_11995	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HXS70_12000	COG2890	protein-(glutamine-N5) methyltransferase activity
HXS70_12005	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HXS70_12010	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HXS70_12025	COG2226	methyltransferase
HXS70_12030	COG0534	Mate efflux family protein
HXS70_12080	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HXS70_12085	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HXS70_12090	COG3525	Glycosyl hydrolase, family 20, catalytic domain
HXS70_12110	COG1121	(ABC) transporter
HXS70_12115	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HXS70_12120	COG3880	PFAM UvrB UvrC protein
HXS70_12125	COG3869	Catalyzes the specific phosphorylation of arginine residues in
HXS70_12130	COG0542	response to heat
HXS70_12145	COG0179	Fumarylacetoacetate (FAA) hydrolase
HXS70_12150	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HXS70_12165	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HXS70_12165	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HXS70_12175	COG0180	Tryptophanyl-tRNA synthetase
HXS70_12185	COG1692	metallophosphoesterase
HXS70_12190	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HXS70_12205	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HXS70_12210	COG2816	NAD+ diphosphatase activity
HXS70_12215	COG0156	8-amino-7-oxononanoate synthase activity
HXS70_12235	COG0515	serine threonine protein kinase
HXS70_12235	COG3266	domain, Protein
HXS70_12490	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HXS70_12505	COG3189	MarR family transcriptional regulator
HXS70_12515	COG0181	hydroxymethylbilane synthase activity
HXS70_12520	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HXS70_12530	COG1469	GTP cyclohydrolase I activity
HXS70_12535	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HXS70_12540	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HXS70_12545	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HXS70_12550	COG1940	carbohydrate kinase activity
HXS70_12565	COG0494	nUDIX hydrolase
HXS70_12570	COG1566	PFAM secretion protein HlyD family protein
HXS70_12575	COG0577	efflux transmembrane transporter activity
HXS70_12575	COG1136	(ABC) transporter
HXS70_12580	COG1136	(ABC) transporter
HXS70_12580	COG0577	efflux transmembrane transporter activity
HXS70_12600	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HXS70_12610	COG1720	tRNA m6t6A37 methyltransferase activity
HXS70_12615	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HXS70_12620	COG0540	Belongs to the ATCase OTCase family
HXS70_12625	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
HXS70_12645	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
HXS70_12650	COG2957	Belongs to the agmatine deiminase family
HXS70_12665	COG3119	arylsulfatase activity
HXS70_12675	COG1918	ferrous iron import across plasma membrane
HXS70_12675	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
HXS70_12725	COG1475	DNA binding
HXS70_12760	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HXS70_12775	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HXS70_12780	COG0601	transmembrane transport
HXS70_12825	COG0849	cell division
HXS70_12835	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HXS70_12840	COG1132	(ABC) transporter
HXS70_12845	COG1132	(ABC) transporter
HXS70_12860	COG1127	ABC transporter
HXS70_12865	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HXS70_12895	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HXS70_12910	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
HXS70_12915	COG0504	CTP synthase activity
HXS70_12920	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HXS70_12950	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HXS70_12965	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HXS70_12975	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HXS70_12995	COG1322	Protein conserved in bacteria