locus-tag	class	description
C1O51_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
C1O51_00010	COG1131	(ABC) transporter
C1O51_00030	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
C1O51_00035	COG0564	pseudouridine synthase activity
C1O51_00055	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
C1O51_00080	COG0673	inositol 2-dehydrogenase activity
C1O51_00095	COG2814	Major facilitator Superfamily
C1O51_00100	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
C1O51_00120	COG1971	Probably functions as a manganese efflux pump
C1O51_00145	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C1O51_00170	COG0442	prolyl-tRNA aminoacylation
C1O51_00185	COG2963	transposase activity
C1O51_00215	COG0531	amino acid
C1O51_00220	COG2066	Belongs to the glutaminase family
C1O51_00235	COG1115	amino acid carrier protein
C1O51_00245	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
C1O51_00250	COG2890	protein-(glutamine-N5) methyltransferase activity
C1O51_00255	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
C1O51_00260	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
C1O51_00285	COG0534	Mate efflux family protein
C1O51_00330	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C1O51_00335	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
C1O51_00340	COG3525	Glycosyl hydrolase, family 20, catalytic domain
C1O51_00355	COG1121	(ABC) transporter
C1O51_00360	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C1O51_00365	COG3880	PFAM UvrB UvrC protein
C1O51_00370	COG3869	Catalyzes the specific phosphorylation of arginine residues in
C1O51_00375	COG0542	response to heat
C1O51_00385	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C1O51_00390	COG0179	Fumarylacetoacetate (FAA) hydrolase
C1O51_00395	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C1O51_00410	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
C1O51_00410	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
C1O51_00420	COG0180	Tryptophanyl-tRNA synthetase
C1O51_00430	COG1692	metallophosphoesterase
C1O51_00440	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
C1O51_00500	COG0515	serine threonine protein kinase
C1O51_00510	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
C1O51_00515	COG0732	type I restriction modification DNA specificity domain
C1O51_00525	COG1715	Restriction endonuclease
C1O51_00590	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C1O51_00595	COG2816	NAD+ diphosphatase activity
C1O51_00605	COG0156	8-amino-7-oxononanoate synthase activity
C1O51_00620	COG1192	Involved in chromosome partitioning
C1O51_00665	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
C1O51_00680	COG3189	MarR family transcriptional regulator
C1O51_00690	COG0181	hydroxymethylbilane synthase activity
C1O51_00695	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
C1O51_00705	COG1469	GTP cyclohydrolase I activity
C1O51_00710	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
C1O51_00715	COG0267	Belongs to the bacterial ribosomal protein bL33 family
C1O51_00720	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
C1O51_00725	COG1940	carbohydrate kinase activity
C1O51_00740	COG0494	nUDIX hydrolase
C1O51_00745	COG1566	PFAM secretion protein HlyD family protein
C1O51_00750	COG1136	(ABC) transporter
C1O51_00750	COG0577	efflux transmembrane transporter activity
C1O51_00755	COG1136	(ABC) transporter
C1O51_00755	COG0577	efflux transmembrane transporter activity
C1O51_00760	COG1538	Outer membrane efflux protein
C1O51_00775	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C1O51_00790	COG1720	tRNA m6t6A37 methyltransferase activity
C1O51_00795	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C1O51_00800	COG0540	Belongs to the ATCase OTCase family
C1O51_00805	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
C1O51_00820	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
C1O51_00825	COG2957	Belongs to the agmatine deiminase family
C1O51_00835	COG0750	zinc metalloprotease
C1O51_00845	COG3119	arylsulfatase activity
C1O51_00855	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
C1O51_00855	COG1918	ferrous iron import across plasma membrane
C1O51_00915	COG1475	DNA binding
C1O51_00950	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
C1O51_00970	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C1O51_00975	COG0601	transmembrane transport
C1O51_01030	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C1O51_01035	COG1132	(ABC) transporter
C1O51_01040	COG1132	(ABC) transporter
C1O51_01055	COG1127	ABC transporter
C1O51_01060	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
C1O51_01090	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C1O51_01110	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
C1O51_01115	COG0504	CTP synthase activity
C1O51_01120	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C1O51_01145	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C1O51_01155	COG1322	Protein conserved in bacteria
C1O51_01160	COG0546	phosphoglycolate phosphatase activity
C1O51_01180	COG4591	ABC-type transport system involved in lipoprotein release permease component
C1O51_01180	COG4591	ABC-type transport system involved in lipoprotein release permease component
C1O51_01200	COG3209	COG3209 Rhs family protein
C1O51_01240	COG2234	aminopeptidase activity
C1O51_01245	COG0657	acetylesterase activity
C1O51_01245	COG2755	lipolytic protein G-D-S-L family
C1O51_01250	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
C1O51_01270	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
C1O51_01290	COG0335	large ribosomal subunit rRNA binding
C1O51_01300	COG0346	lactoylglutathione lyase activity
C1O51_01315	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
C1O51_01320	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
C1O51_01325	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
C1O51_01325	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
C1O51_01330	COG0427	acetyl-CoA hydrolase
C1O51_01345	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
C1O51_01355	COG0205	6-phosphofructokinase activity
C1O51_01370	COG0028	Belongs to the TPP enzyme family
C1O51_01415	COG0471	metal ion transport
C1O51_01430	COG0351	phosphomethylpyrimidine kinase
C1O51_01495	COG0242	peptide deformylase activity
C1O51_01500	COG1063	alcohol dehydrogenase
C1O51_01510	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C1O51_01515	COG1393	Belongs to the ArsC family
C1O51_01520	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
C1O51_01530	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C1O51_01550	COG1187	pseudouridine synthase activity
C1O51_01565	COG0336	Belongs to the RNA methyltransferase TrmD family
C1O51_01570	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
C1O51_01580	COG0539	negative regulation of cytoplasmic translation
C1O51_01635	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
C1O51_01640	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
C1O51_01685	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C1O51_01825	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C1O51_01830	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C1O51_01835	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C1O51_01860	COG0733	neurotransmitter:sodium symporter activity
C1O51_01865	COG0450	alkyl hydroperoxide reductase
C1O51_01870	COG0668	transmembrane transport
C1O51_01875	COG0528	UMP kinase activity
C1O51_01880	COG0233	cytoplasmic translational termination
C1O51_01930	COG0612	Peptidase, M16
C1O51_01945	COG2017	converts alpha-aldose to the beta-anomer
C1O51_01955	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
C1O51_01965	COG0573	inorganic phosphate transmembrane transporter activity
C1O51_01970	COG0581	inorganic phosphate transmembrane transporter activity
C1O51_01990	COG0175	sulfate reduction
C1O51_01995	COG0175	sulfate reduction
C1O51_02000	COG2895	sulfate adenylyltransferase (ATP) activity
C1O51_02000	COG0529	Catalyzes the synthesis of activated sulfate
C1O51_02020	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C1O51_02040	COG1262	PFAM Formylglycine-generating sulfatase enzyme
C1O51_02045	COG0826	peptidase U32
C1O51_02055	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
C1O51_02060	COG0187	DNA topoisomerase II activity
C1O51_02075	COG0545	Peptidyl-prolyl cis-trans isomerase
C1O51_02080	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
C1O51_02090	COG1408	metallophosphoesterase
C1O51_02150	COG0492	ferredoxin-NADP+ reductase activity
C1O51_02150	COG3118	belongs to the thioredoxin family
C1O51_02155	COG1760	l-serine dehydratase
C1O51_02170	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
C1O51_02190	COG0676	glucose-6-phosphate 1-epimerase activity
C1O51_02200	COG2755	lipolytic protein G-D-S-L family
C1O51_02200	COG0657	acetylesterase activity
C1O51_02215	COG0230	Belongs to the bacterial ribosomal protein bL34 family
C1O51_02225	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
C1O51_02230	COG0706	membrane insertase activity
C1O51_02245	COG0069	glutamate synthase activity
C1O51_02245	COG0067	glutamate synthase
C1O51_02245	COG0070	glutamate synthase
C1O51_02255	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
C1O51_02260	COG0505	Belongs to the CarA family
C1O51_02265	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
C1O51_02270	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C1O51_02275	COG1757	Na H antiporter
C1O51_02285	COG1482	cell wall glycoprotein biosynthetic process
C1O51_02295	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
C1O51_02305	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
C1O51_02315	COG0848	biopolymer transport protein
C1O51_02320	COG0811	peptide transport
C1O51_02325	COG0322	excinuclease ABC activity
C1O51_02330	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
C1O51_02335	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
C1O51_02340	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
C1O51_02345	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
C1O51_02350	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
C1O51_02350	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
C1O51_02355	COG2003	Belongs to the UPF0758 family
C1O51_02375	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
C1O51_02380	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
C1O51_02400	COG0284	orotidine-5'-phosphate decarboxylase activity
C1O51_02460	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
C1O51_02485	COG0437	4 iron, 4 sulfur cluster binding
C1O51_02495	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
C1O51_02500	COG3409	Peptidoglycan-binding domain 1 protein
C1O51_02500	COG5632	N-Acetylmuramoyl-L-alanine amidase
C1O51_02505	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
C1O51_02515	COG0736	holo-[acyl-carrier-protein] synthase activity
C1O51_02520	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
C1O51_02525	COG0138	bifunctional purine biosynthesis protein purh
C1O51_02530	COG0359	binds to the 23S rRNA
C1O51_02540	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
C1O51_02565	COG1122	ATPase activity
C1O51_02570	COG1199	ATP-dependent helicase activity
C1O51_02580	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
C1O51_02600	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
C1O51_02610	COG0227	Belongs to the bacterial ribosomal protein bL28 family
C1O51_02625	COG1477	protein flavinylation
C1O51_02635	COG0148	phosphopyruvate hydratase activity
C1O51_02660	COG2186	Transcriptional regulator
C1O51_02665	COG1119	ATPase activity
C1O51_02670	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
C1O51_02685	COG1090	epimerase
C1O51_02710	COG2311	Membrane
C1O51_02715	COG0714	Associated with various cellular activities
C1O51_02765	COG0789	Transcriptional regulator
C1O51_02780	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C1O51_02805	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
C1O51_02810	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
C1O51_02815	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
C1O51_02870	COG3209	COG3209 Rhs family protein
C1O51_02920	COG1876	peptidase activity
C1O51_02965	COG1373	ATPase (AAA superfamily
C1O51_02975	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C1O51_02980	COG0534	Mate efflux family protein
C1O51_03000	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
C1O51_03005	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
C1O51_03040	COG1368	sulfuric ester hydrolase activity
C1O51_03105	COG0129	dihydroxy-acid dehydratase activity
C1O51_03110	COG0745	RESPONSE REGULATOR receiver
C1O51_03115	COG5002	protein histidine kinase activity
C1O51_03140	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
C1O51_03145	COG0006	proline dipeptidase activity
C1O51_03155	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
C1O51_03160	COG1363	Peptidase, m42
C1O51_03190	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
C1O51_03195	COG2217	Heavy metal translocating P-type atpase
C1O51_03200	COG1940	carbohydrate kinase activity
C1O51_03205	COG0590	tRNA wobble adenosine to inosine editing
C1O51_03210	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
C1O51_03215	COG1858	cytochrome C peroxidase
C1O51_03230	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
C1O51_03280	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C1O51_03285	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
C1O51_03310	COG0514	ATP-dependent DNA helicase (RecQ)
C1O51_03315	COG3119	arylsulfatase activity
C1O51_03325	COG1902	pentaerythritol trinitrate reductase activity
C1O51_03325	COG0446	pyridine nucleotide-disulphide oxidoreductase
C1O51_03340	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
C1O51_03345	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
C1O51_03350	COG2226	methyltransferase
C1O51_03395	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C1O51_03415	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
C1O51_03430	COG0544	peptidyl-prolyl cis-trans isomerase activity
C1O51_03435	COG0740	serine-type endopeptidase activity
C1O51_03445	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
C1O51_03455	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
C1O51_03470	COG0250	Participates in transcription elongation, termination and antitermination
C1O51_03475	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
C1O51_03480	COG0081	regulation of translation
C1O51_03485	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
C1O51_03490	COG0222	ribosome binding
C1O51_03495	COG0085	RNA polymerase activity
C1O51_03500	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
C1O51_03520	COG0481	GTPase activity
C1O51_03530	COG3119	arylsulfatase activity
C1O51_03540	COG0215	cysteine-tRNA ligase activity
C1O51_03550	COG0697	spore germination
C1O51_03555	COG0488	(ABC) transporter
C1O51_03560	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
C1O51_03590	COG2095	MarC family integral membrane protein
C1O51_03595	COG2267	carboxylic ester hydrolase activity
C1O51_03650	COG0667	Aldo Keto reductase
C1O51_03660	COG1073	alpha beta
C1O51_03670	COG1028	Short-chain dehydrogenase reductase Sdr
C1O51_03675	COG1253	flavin adenine dinucleotide binding
C1O51_03690	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
C1O51_03700	COG0488	(ABC) transporter
C1O51_03710	COG1028	Short-chain dehydrogenase reductase Sdr
C1O51_03735	COG0482	sulfurtransferase activity
C1O51_03740	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
C1O51_03760	COG2860	membrane
C1O51_03765	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
C1O51_03770	COG2001	Belongs to the MraZ family
C1O51_03775	COG0275	rRNA processing
C1O51_03785	COG0768	penicillin binding
C1O51_03790	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
C1O51_03795	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
C1O51_03800	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C1O51_03805	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
C1O51_03815	COG0772	Belongs to the SEDS family
C1O51_03820	COG0772	Belongs to the SEDS family
C1O51_03825	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
C1O51_03830	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C1O51_03835	COG1181	Belongs to the D-alanine--D-alanine ligase family
C1O51_03845	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
C1O51_03850	COG0860	N-Acetylmuramoyl-L-alanine amidase
C1O51_03855	COG0321	lipoyl(octanoyl) transferase activity
C1O51_03860	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
C1O51_03865	COG0066	3-isopropylmalate dehydratase activity
C1O51_03875	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C1O51_03885	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
C1O51_03890	COG4608	Belongs to the ABC transporter superfamily
C1O51_03895	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
C1O51_03910	COG2877	3-deoxy-8-phosphooctulonate synthase activity
C1O51_03925	COG1137	ATPase activity
C1O51_03935	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C1O51_03970	COG0017	Asparaginyl-tRNA synthetase
C1O51_03985	COG3118	belongs to the thioredoxin family
C1O51_04030	COG0583	DNA-binding transcription factor activity
C1O51_04035	COG2855	membrane
C1O51_04040	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
C1O51_04055	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C1O51_04065	COG0602	queuosine metabolic process
C1O51_04070	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
C1O51_04075	COG0217	transcriptional regulatory protein
C1O51_04080	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
C1O51_04085	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
C1O51_04085	COG4651	solute:proton antiporter activity
C1O51_04095	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
C1O51_04100	COG4864	UPF0365 protein
C1O51_04110	COG2022	thiamine diphosphate biosynthetic process
C1O51_04115	COG0531	amino acid
C1O51_04125	COG0628	permease
C1O51_04130	COG0019	diaminopimelate decarboxylase activity
C1O51_04135	COG0191	fructose-bisphosphate aldolase activity
C1O51_04175	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
C1O51_04185	COG1181	Belongs to the D-alanine--D-alanine ligase family
C1O51_04215	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C1O51_04220	COG0516	GMP reductase activity
C1O51_04220	COG0517	IMP dehydrogenase activity
C1O51_04225	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C1O51_04225	COG0519	Catalyzes the synthesis of GMP from XMP
C1O51_04230	COG1196	nuclear chromosome segregation
C1O51_04240	COG0546	phosphoglycolate phosphatase activity
C1O51_04265	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
C1O51_04280	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
C1O51_04285	COG0196	riboflavin kinase activity
C1O51_04290	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
C1O51_04305	COG1408	metallophosphoesterase
C1O51_04315	COG1442	glycosyl transferase family 8
C1O51_04315	COG1216	Glycosyl transferase, family 2
C1O51_04325	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C1O51_04330	COG1216	Glycosyl transferase, family 2
C1O51_04350	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
C1O51_04350	COG2755	lipolytic protein G-D-S-L family
C1O51_04365	COG0471	metal ion transport
C1O51_04365	COG0490	domain, Protein
C1O51_04405	COG0588	phosphoglycerate mutase activity
C1O51_04410	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C1O51_04420	COG0477	Major facilitator Superfamily
C1O51_04425	COG1607	acyl-coa hydrolase
C1O51_04435	COG1028	Short-chain dehydrogenase reductase Sdr
C1O51_04475	COG1475	DNA binding
C1O51_04480	COG3969	phosphoadenosine phosphosulfate
C1O51_04495	COG0473	3-isopropylmalate dehydrogenase activity
C1O51_04510	COG0606	chelatase, subunit chli
C1O51_04545	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
C1O51_04550	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
C1O51_04560	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
C1O51_04585	COG1733	regulation of RNA biosynthetic process
C1O51_04595	COG0107	imidazoleglycerol-phosphate synthase activity
C1O51_04600	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C1O51_04610	COG1643	Atp-dependent helicase
C1O51_04615	COG0440	acetolactate synthase activity
C1O51_04620	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C1O51_04630	COG0445	tRNA wobble uridine modification
C1O51_04635	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C1O51_04635	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C1O51_04640	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
C1O51_04650	COG0592	DNA-directed DNA polymerase activity
C1O51_04755	COG0791	NLP P60 protein
C1O51_04755	COG1388	LysM domain
C1O51_04760	COG0084	hydrolase, TatD family'
C1O51_04770	COG3250	beta-galactosidase activity
C1O51_04785	COG2205	protein histidine kinase activity
C1O51_04790	COG0745	RESPONSE REGULATOR receiver
C1O51_04800	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
C1O51_04825	COG0542	response to heat
C1O51_04875	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
C1O51_04885	COG0659	secondary active sulfate transmembrane transporter activity
C1O51_04890	COG0165	Argininosuccinate lyase
C1O51_04910	COG0148	phosphopyruvate hydratase activity
C1O51_04915	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
C1O51_04925	COG3481	metal-dependent phosphohydrolase, HD sub domain
C1O51_04935	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C1O51_04940	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C1O51_04960	COG0732	type I restriction modification DNA specificity domain
C1O51_05015	COG2963	transposase activity
C1O51_05030	COG0490	domain, Protein
C1O51_05030	COG2985	domain, Protein
C1O51_05045	COG0471	metal ion transport
C1O51_05075	COG2194	sulfuric ester hydrolase activity
C1O51_05085	COG1592	Rubrerythrin
C1O51_05095	COG1363	Peptidase, m42
C1O51_05100	COG3525	Glycosyl hydrolase, family 20, catalytic domain
C1O51_05110	COG1785	Belongs to the alkaline phosphatase family
C1O51_05115	COG1970	mechanosensitive ion channel activity
C1O51_05120	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C1O51_05130	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
C1O51_05140	COG2217	Heavy metal translocating P-type atpase
C1O51_05145	COG0497	DNA recombination
C1O51_05150	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
C1O51_05150	COG0321	lipoyl(octanoyl) transferase activity
C1O51_05185	COG0508	dehydrogenase complex catalyzes the overall conversion of
C1O51_05190	COG0022	dehydrogenase e1 component
C1O51_05195	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
C1O51_05200	COG0789	Transcriptional regulator
C1O51_05205	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C1O51_05210	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C1O51_05215	COG3210	domain, Protein
C1O51_05265	COG3409	Peptidoglycan-binding domain 1 protein
C1O51_05265	COG5632	N-Acetylmuramoyl-L-alanine amidase
C1O51_05270	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
C1O51_05295	COG1690	Belongs to the RtcB family
C1O51_05305	COG2814	Major facilitator Superfamily
C1O51_05315	COG2096	Adenosyltransferase
C1O51_05325	COG0557	exoribonuclease II activity
C1O51_05350	COG0826	peptidase U32
C1O51_05355	COG0285	dihydrofolate synthase activity
C1O51_05370	COG0673	inositol 2-dehydrogenase activity
C1O51_05375	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C1O51_05380	COG0737	Belongs to the 5'-nucleotidase family
C1O51_05390	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
C1O51_05395	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
C1O51_05405	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
C1O51_05410	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
C1O51_05415	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
C1O51_05420	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
C1O51_05425	COG0200	Binds to the 23S rRNA
C1O51_05435	COG0563	adenylate kinase activity
C1O51_05440	COG0024	Methionine aminopeptidase
C1O51_05455	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
C1O51_05460	COG1442	glycosyl transferase family 8
C1O51_05470	COG1216	Glycosyl transferase, family 2
C1O51_05480	COG1216	Glycosyl transferase, family 2
C1O51_05495	COG1216	Glycosyl transferase, family 2
C1O51_05500	COG0693	protein deglycase activity
C1O51_05505	COG0508	dehydrogenase complex catalyzes the overall conversion of
C1O51_05510	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
C1O51_05515	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
C1O51_05530	COG1966	Carbon starvation protein
C1O51_05540	COG3119	arylsulfatase activity
C1O51_05545	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
C1O51_05550	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
C1O51_05555	COG0195	Participates in both transcription termination and antitermination
C1O51_05560	COG0708	Exodeoxyribonuclease III
C1O51_05565	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
C1O51_05570	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
C1O51_05575	COG2006	4fe-4S ferredoxin, iron-sulfur binding domain protein
C1O51_05585	COG1131	(ABC) transporter
C1O51_05585	COG0842	Transport permease protein
C1O51_05585	COG1716	ATPase activity
C1O51_05605	COG0724	RNA recognition motif
C1O51_05610	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
C1O51_05630	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
C1O51_05640	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
C1O51_05645	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C1O51_05660	COG1490	D-aminoacyl-tRNA deacylase activity
C1O51_05680	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
C1O51_05685	COG1053	succinate dehydrogenase
C1O51_05720	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
C1O51_05730	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
C1O51_05740	COG0438	transferase activity, transferring glycosyl groups
C1O51_05765	COG0463	Glycosyl transferase, family 2
C1O51_05765	COG1216	Glycosyl transferase, family 2
C1O51_05770	COG1215	transferase activity, transferring glycosyl groups
C1O51_05775	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
C1O51_05780	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C1O51_05785	COG2255	four-way junction helicase activity
C1O51_05830	COG2076	Multidrug Resistance protein
C1O51_05840	COG2226	methyltransferase
C1O51_05855	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
C1O51_05875	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
C1O51_05890	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
C1O51_05895	COG0708	Exodeoxyribonuclease III
C1O51_05940	COG3210	domain, Protein
C1O51_05940	COG4625	pathogenesis
C1O51_05960	COG0863	Belongs to the N(4) N(6)-methyltransferase family
C1O51_05970	COG0571	ribonuclease III activity
C1O51_05980	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
C1O51_05990	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
C1O51_06020	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
C1O51_06025	COG0424	maF-like protein
C1O51_06030	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C1O51_06050	COG3034	peptidoglycan biosynthetic process
C1O51_06055	COG0673	inositol 2-dehydrogenase activity
C1O51_06090	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
C1O51_06110	COG0612	Peptidase, M16
C1O51_06115	COG1663	tetraacyldisaccharide 4'-kinase activity
C1O51_06135	COG3956	TIGRFAM MazG family protein
C1O51_06145	COG1040	competence protein
C1O51_06180	COG0149	triose-phosphate isomerase activity
C1O51_06195	COG0137	argininosuccinate synthase activity
C1O51_06210	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
C1O51_06220	COG1253	flavin adenine dinucleotide binding
C1O51_06230	COG0792	nuclease activity
C1O51_06240	COG0134	indole-3-glycerol-phosphate synthase activity
C1O51_06265	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
C1O51_06280	COG0848	biopolymer transport protein
C1O51_06310	COG1530	ribonuclease E activity
C1O51_06315	COG1077	Cell shape determining protein MreB Mrl
C1O51_06330	COG1363	Peptidase, m42
C1O51_06340	COG0047	phosphoribosylformylglycinamidine synthase activity
C1O51_06345	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
C1O51_06355	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
C1O51_06365	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
C1O51_06370	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
C1O51_06375	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
C1O51_06410	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
C1O51_06460	COG0356	it plays a direct role in the translocation of protons across the membrane
C1O51_06470	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
C1O51_06475	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
C1O51_06480	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
C1O51_06485	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
C1O51_06490	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
C1O51_06495	COG0355	proton-transporting ATP synthase activity, rotational mechanism
C1O51_06515	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C1O51_06560	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
C1O51_06585	COG0719	Fe-S assembly protein
C1O51_06590	COG0396	ATPase activity
C1O51_06595	COG0735	belongs to the Fur family
C1O51_06600	COG0211	Belongs to the bacterial ribosomal protein bL27 family
C1O51_06610	COG0802	atpase or kinase
C1O51_06615	COG1073	alpha beta
C1O51_06625	COG5434	Belongs to the glycosyl hydrolase 28 family
C1O51_06640	COG2326	polyphosphate kinase activity
C1O51_06655	COG0742	ribosomal rna small subunit methyltransferase
C1O51_06670	COG1162	GTPase activity
C1O51_06675	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
C1O51_06695	COG1349	DNA-binding transcription factor activity
C1O51_06700	COG2326	polyphosphate kinase activity
C1O51_06720	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
C1O51_06750	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
C1O51_06755	COG2259	Doxx family
C1O51_06785	COG3119	arylsulfatase activity
C1O51_06800	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C1O51_06800	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C1O51_06810	COG0404	The glycine cleavage system catalyzes the degradation of glycine
C1O51_06815	COG0012	GTP binding
C1O51_06820	COG1686	Belongs to the peptidase S11 family
C1O51_06825	COG0758	DNA mediated transformation
C1O51_06840	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
C1O51_06845	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
C1O51_06850	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
C1O51_06855	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
C1O51_06875	COG0456	acetyltransferase
C1O51_06885	COG1058	Belongs to the CinA family
C1O51_06885	COG1546	Belongs to the CinA family
C1O51_06900	COG0820	rRNA (adenine-C2-)-methyltransferase activity
C1O51_06905	COG0552	protein localization to endoplasmic reticulum
C1O51_06910	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C1O51_06915	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
C1O51_06920	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C1O51_06920	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C1O51_06925	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C1O51_06935	COG2814	Major facilitator Superfamily
C1O51_06950	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
C1O51_06955	COG0828	Belongs to the bacterial ribosomal protein bS21 family
C1O51_06970	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
C1O51_06975	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
C1O51_06980	COG3525	Glycosyl hydrolase, family 20, catalytic domain
C1O51_06995	COG1116	anion transmembrane transporter activity
C1O51_07005	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C1O51_07015	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
C1O51_07020	COG1136	(ABC) transporter
C1O51_07040	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
C1O51_07045	COG3525	Glycosyl hydrolase, family 20, catalytic domain
C1O51_07060	COG4968	Prepilin-type N-terminal cleavage methylation domain
C1O51_07080	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
C1O51_07085	COG0101	tRNA pseudouridine synthase activity
C1O51_07115	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
C1O51_07120	COG1185	polyribonucleotide nucleotidyltransferase activity
C1O51_07125	COG1253	flavin adenine dinucleotide binding
C1O51_07130	COG1253	flavin adenine dinucleotide binding
C1O51_07150	COG0352	thiamine-phosphate diphosphorylase activity
C1O51_07155	COG0167	dihydroorotate dehydrogenase activity
C1O51_07170	COG0076	glutamate decarboxylase activity
C1O51_07185	COG3525	Glycosyl hydrolase, family 20, catalytic domain
C1O51_07195	COG0038	chloride channel
C1O51_07215	COG4221	oxidoreductase activity
C1O51_07225	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
C1O51_07240	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
C1O51_07295	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C1O51_07300	COG0799	negative regulation of ribosome biogenesis
C1O51_07370	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
C1O51_07420	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
C1O51_07430	COG0577	efflux transmembrane transporter activity
C1O51_07430	COG1136	(ABC) transporter
C1O51_07445	COG0444	Belongs to the ABC transporter superfamily
C1O51_07450	COG1160	GTP binding
C1O51_07455	COG0795	lipopolysaccharide-transporting ATPase activity
C1O51_07470	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
C1O51_07475	COG1722	exodeoxyribonuclease VII activity
C1O51_07485	COG2204	response regulator
C1O51_07490	COG3852	Histidine kinase
C1O51_07500	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
C1O51_07505	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
C1O51_07510	COG0049	tRNA binding
C1O51_07515	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
C1O51_07520	COG0051	transcription antitermination factor activity, RNA binding
C1O51_07525	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
C1O51_07530	COG0088	Forms part of the polypeptide exit tunnel
C1O51_07535	COG0089	rRNA binding
C1O51_07540	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
C1O51_07545	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
C1O51_07555	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
C1O51_07560	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
C1O51_07565	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
C1O51_07570	COG0255	Belongs to the universal ribosomal protein uL29 family
C1O51_07575	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
C1O51_07580	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
C1O51_07595	COG3250	beta-galactosidase activity
C1O51_07610	COG0811	peptide transport
C1O51_07645	COG0776	regulation of translation
C1O51_07650	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
C1O51_07655	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
C1O51_07665	COG0220	tRNA (guanine-N7-)-methyltransferase activity
C1O51_07675	COG1862	Preprotein translocase
C1O51_07700	COG0228	four-way junction DNA binding
C1O51_07705	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
C1O51_07710	COG0009	L-threonylcarbamoyladenylate synthase
C1O51_07715	COG0537	adenosine 5'-monophosphoramidase activity
C1O51_07725	COG0333	Belongs to the bacterial ribosomal protein bL32 family
C1O51_07730	COG0416	fatty acid biosynthetic process
C1O51_07740	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
C1O51_07740	COG0662	Cupin 2, conserved barrel domain protein
C1O51_07835	COG0305	Participates in initiation and elongation during chromosome replication
C1O51_07850	COG0842	Transport permease protein
C1O51_07855	COG0842	Transport permease protein
C1O51_07860	COG1131	(ABC) transporter
C1O51_07870	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
C1O51_07875	COG1183	phosphatidylcholine synthase activity
C1O51_07885	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
C1O51_07895	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
C1O51_07900	COG1028	Short-chain dehydrogenase reductase Sdr
C1O51_07925	COG0156	8-amino-7-oxononanoate synthase activity
C1O51_07950	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
C1O51_07955	COG0124	histidyl-tRNA synthetase
C1O51_07960	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
C1O51_07965	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
C1O51_07970	COG0298	carbon dioxide binding
C1O51_08000	COG0443	Heat shock 70 kDa protein
C1O51_08005	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
C1O51_08010	COG0459	protein refolding
C1O51_08060	COG0632	four-way junction helicase activity
C1O51_08070	COG0126	phosphoglycerate kinase activity
C1O51_08085	COG1082	Xylose isomerase domain protein TIM barrel
C1O51_08095	COG0863	Belongs to the N(4) N(6)-methyltransferase family
C1O51_08110	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
C1O51_08120	COG2271	Major facilitator Superfamily
C1O51_08135	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
C1O51_08145	COG0037	tRNA processing
C1O51_08150	COG0254	rRNA binding
C1O51_08185	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
C1O51_08190	COG0039	L-malate dehydrogenase activity
C1O51_08215	COG0778	Nitroreductase
C1O51_08220	COG0564	pseudouridine synthase activity
C1O51_08245	COG1126	abc transporter atp-binding protein
C1O51_08250	COG0765	amino acid transport
C1O51_08260	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
C1O51_08265	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
C1O51_08285	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
C1O51_08315	COG1872	DUF167
C1O51_08320	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
C1O51_08325	COG0484	heat shock protein binding
C1O51_08330	COG1385	rRNA (uridine-N3-)-methyltransferase activity
C1O51_08340	COG5434	Belongs to the glycosyl hydrolase 28 family
C1O51_08355	COG0277	FAD linked oxidase domain protein
C1O51_08380	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
C1O51_08385	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
C1O51_08395	COG0131	Imidazoleglycerol-phosphate dehydratase
C1O51_08400	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
C1O51_08405	COG0360	Binds together with S18 to 16S ribosomal RNA
C1O51_08415	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
C1O51_08430	COG1686	Belongs to the peptidase S11 family
C1O51_08435	COG0205	6-phosphofructokinase activity
C1O51_08445	COG0428	transporter
C1O51_08450	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C1O51_08460	COG3977	Valine--pyruvate aminotransferase
C1O51_08465	COG1561	YicC-like family, N-terminal region
C1O51_08480	COG0471	metal ion transport
C1O51_08480	COG3273	potassium ion transport
C1O51_08485	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C1O51_08500	COG1575	Belongs to the MenA family. Type 1 subfamily
C1O51_08530	COG0726	polysaccharide deacetylase
C1O51_08535	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C1O51_08535	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C1O51_08560	COG0202	RNA polymerase activity
C1O51_08565	COG0203	ribosomal protein L17
C1O51_08570	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
C1O51_08575	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C1O51_08595	COG2885	chlorophyll binding
C1O51_08660	COG0667	Aldo Keto reductase
C1O51_08665	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
C1O51_08680	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
C1O51_08685	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
C1O51_08690	COG0134	indole-3-glycerol-phosphate synthase activity
C1O51_08695	COG0135	phosphoribosylanthranilate isomerase activity
C1O51_08700	COG0133	tryptophan synthase activity
C1O51_08705	COG0159	tryptophan synthase activity
C1O51_08720	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C1O51_08725	COG0257	Belongs to the bacterial ribosomal protein bL36 family
C1O51_08740	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
C1O51_08775	COG0561	phosphatase activity
C1O51_08780	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C1O51_08785	COG2223	nitrite transmembrane transporter activity
C1O51_08790	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
C1O51_08830	COG0556	nucleotide-excision repair
C1O51_08835	COG0291	Belongs to the bacterial ribosomal protein bL35 family
C1O51_08840	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
C1O51_08860	COG1074	ATP-dependent DNA helicase activity
C1O51_08870	COG0697	spore germination
C1O51_08880	COG2373	Large extracellular alpha-helical protein
C1O51_08885	COG1979	alcohol dehydrogenase
C1O51_08895	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C1O51_08920	COG0372	Belongs to the citrate synthase family
C1O51_08935	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
C1O51_08945	COG1187	pseudouridine synthase activity
C1O51_08955	COG0105	UTP biosynthetic process
C1O51_08960	COG1215	transferase activity, transferring glycosyl groups
C1O51_08965	COG0463	Glycosyl transferase, family 2
C1O51_08975	COG1459	type II secretion system
C1O51_08980	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
C1O51_08990	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C1O51_09005	COG0728	peptidoglycan biosynthetic process
C1O51_09010	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
C1O51_09010	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
C1O51_09025	COG1649	PFAM Uncharacterised BCR, COG1649
C1O51_09030	COG1691	(AIR) carboxylase
C1O51_09035	COG1606	tRNA processing
C1O51_09040	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
C1O51_09045	COG0142	geranyltranstransferase activity
C1O51_09060	COG2151	metal-sulfur cluster biosynthetic enzyme
C1O51_09075	COG1007	ATP synthesis coupled electron transport
C1O51_09080	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C1O51_09090	COG0713	ATP synthesis coupled electron transport
C1O51_09095	COG0839	Belongs to the complex I subunit 6 family
C1O51_09105	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
C1O51_09110	COG1034	ATP synthesis coupled electron transport
C1O51_09115	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
C1O51_09120	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
C1O51_09125	COG0649	NAD binding
C1O51_09135	COG0726	polysaccharide deacetylase
C1O51_09145	COG0307	riboflavin synthase, alpha
C1O51_09155	COG2264	protein methyltransferase activity
C1O51_09160	COG3210	domain, Protein
C1O51_09165	COG1640	4-alpha-glucanotransferase
C1O51_09175	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C1O51_09180	COG1030	water channel activity
C1O51_09185	COG0358	DNA primase activity
C1O51_09190	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C1O51_09195	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
C1O51_09210	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
C1O51_09215	COG0793	Belongs to the peptidase S41A family
C1O51_09230	COG1643	Atp-dependent helicase
C1O51_09260	COG1450	Type ii and iii secretion system protein
C1O51_09275	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
C1O51_09295	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C1O51_09300	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
C1O51_09310	COG0268	Binds directly to 16S ribosomal RNA
C1O51_09315	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C1O51_09320	COG0028	Belongs to the TPP enzyme family
C1O51_09330	COG0688	phosphatidylethanolamine metabolic process
C1O51_09335	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
C1O51_09345	COG3119	arylsulfatase activity
C1O51_09360	COG1166	arginine decarboxylase activity
C1O51_09380	COG3250	beta-galactosidase activity
C1O51_09385	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
C1O51_09390	COG3525	Glycosyl hydrolase, family 20, catalytic domain
C1O51_09410	COG0205	6-phosphofructokinase activity
C1O51_09455	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
C1O51_09460	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
C1O51_09465	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
C1O51_09480	COG4771	TonB-dependent receptor
C1O51_09500	COG0402	S-adenosylhomocysteine deaminase activity
C1O51_09505	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C1O51_09525	COG1294	oxidase, subunit
C1O51_09530	COG1271	oxidase subunit
C1O51_09540	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C1O51_09560	COG1846	Transcriptional regulator
C1O51_09585	COG2949	membrane
C1O51_09605	COG0514	ATP-dependent DNA helicase (RecQ)
C1O51_09620	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
C1O51_09625	COG0045	succinate-CoA ligase (ADP-forming) activity
C1O51_09695	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C1O51_09700	COG2205	protein histidine kinase activity
C1O51_09715	COG0113	porphobilinogen synthase activity
C1O51_09730	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
C1O51_09750	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
C1O51_09780	COG4106	trans-aconitate 2-methyltransferase activity
C1O51_09795	COG3475	LICD family
C1O51_09800	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
C1O51_09810	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C1O51_09815	COG3475	LICD family
C1O51_09820	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
C1O51_09830	COG2166	iron-sulfur cluster assembly
C1O51_09835	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
C1O51_09845	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C1O51_09850	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C1O51_09855	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
C1O51_09860	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C1O51_09865	COG1131	(ABC) transporter
C1O51_09880	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
C1O51_09895	COG1215	transferase activity, transferring glycosyl groups
C1O51_09905	COG2967	ApaG domain
C1O51_09910	COG1401	restriction endodeoxyribonuclease activity
C1O51_09910	COG1401	restriction endodeoxyribonuclease activity
C1O51_09925	COG1522	sequence-specific DNA binding
C1O51_09930	COG0436	Aminotransferase
C1O51_09945	COG0423	glycine-tRNA ligase activity
C1O51_09950	COG0656	L-ascorbic acid biosynthetic process
C1O51_09985	COG0714	Associated with various cellular activities
C1O51_09990	COG0154	amidase activity
C1O51_09995	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C1O51_10035	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C1O51_10040	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C1O51_10050	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
C1O51_10050	COG2755	lipolytic protein G-D-S-L family
C1O51_10080	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
C1O51_10090	COG0656	L-ascorbic acid biosynthetic process
C1O51_10100	COG0667	Aldo Keto reductase
C1O51_10105	COG1408	metallophosphoesterase
C1O51_10125	COG0789	Transcriptional regulator
C1O51_10140	COG0534	Mate efflux family protein
C1O51_10165	COG1091	dTDP-4-dehydrorhamnose reductase activity
C1O51_10180	COG1837	Belongs to the UPF0109 family
C1O51_10185	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
C1O51_10190	COG0363	glucosamine-6-phosphate deaminase activity
C1O51_10205	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
C1O51_10225	COG1741	Belongs to the pirin family
C1O51_10245	COG1070	Carbohydrate kinase
C1O51_10255	COG0738	Major facilitator superfamily
C1O51_10270	COG1595	DNA-templated transcription, initiation
C1O51_10295	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
C1O51_10315	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C1O51_10320	COG0232	Belongs to the dGTPase family. Type 2 subfamily
C1O51_10335	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C1O51_10340	COG4608	Belongs to the ABC transporter superfamily
C1O51_10345	COG0444	Belongs to the ABC transporter superfamily
C1O51_10350	COG4166	transmembrane transport
C1O51_10355	COG4239	(ABC) transporter, permease
C1O51_10360	COG0601	transmembrane transport
C1O51_10375	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
C1O51_10380	COG2759	Belongs to the formate--tetrahydrofolate ligase family
C1O51_10385	COG3738	Protein conserved in bacteria
C1O51_10390	COG0151	Belongs to the GarS family
C1O51_10400	COG0811	peptide transport
C1O51_10410	COG0242	peptide deformylase activity
C1O51_10445	COG2010	Cytochrome c
C1O51_10455	COG3258	Cytochrome c
C1O51_10470	COG3274	enterobacterial common antigen metabolic process
C1O51_10475	COG0538	isocitrate dehydrogenase activity
C1O51_10490	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
C1O51_10495	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
C1O51_10500	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
C1O51_10510	COG0668	transmembrane transport
C1O51_10515	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C1O51_10515	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
C1O51_10520	COG0805	protein transport
C1O51_10525	COG1968	undecaprenyl-diphosphatase activity
C1O51_10545	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
C1O51_10555	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
C1O51_10565	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
C1O51_10575	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
C1O51_10585	COG1408	metallophosphoesterase
C1O51_10610	COG4974	Belongs to the 'phage' integrase family
C1O51_10635	COG1454	alcohol dehydrogenase
C1O51_10640	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
C1O51_10655	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
C1O51_10655	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
C1O51_10660	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
C1O51_10700	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
C1O51_10710	COG4607	ABC-type enterochelin transport system periplasmic component
C1O51_10715	COG4604	ABC transporter, ATP-binding protein
C1O51_10720	COG4605	iron ion homeostasis
C1O51_10725	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C1O51_10760	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C1O51_10760	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C1O51_10775	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
C1O51_10780	COG2195	Cleaves the N-terminal amino acid of tripeptides
C1O51_10815	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
C1O51_10840	COG0519	Catalyzes the synthesis of GMP from XMP
C1O51_10840	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C1O51_10845	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
C1O51_10890	COG2966	Psort location CytoplasmicMembrane, score
C1O51_10895	COG3610	response to peptide
C1O51_10910	COG0732	type I restriction modification DNA specificity domain
C1O51_10915	COG3177	Filamentation induced by cAMP protein fic
C1O51_10920	COG4974	Belongs to the 'phage' integrase family
C1O51_10925	COG0732	type I restriction modification DNA specificity domain
C1O51_10930	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
C1O51_10940	COG0460	homoserine dehydrogenase
C1O51_10945	COG0527	aspartate kinase activity
C1O51_10955	COG5522	Integral membrane protein (intg_mem_TP0381)
C1O51_10965	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C1O51_10970	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C1O51_10980	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
C1O51_10995	COG0166	Belongs to the GPI family
C1O51_11005	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
C1O51_11015	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
C1O51_11015	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
C1O51_11050	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
C1O51_11055	COG2818	Glycosylase
C1O51_11070	COG0515	serine threonine protein kinase
C1O51_11070	COG2815	serine threonine protein kinase
C1O51_11080	COG3033	Beta-eliminating lyase
C1O51_11095	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C1O51_11095	COG0072	phenylalanine-tRNA ligase activity
C1O51_11115	COG0326	Molecular chaperone. Has ATPase activity
C1O51_11120	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
C1O51_11145	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
C1O51_11160	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C1O51_11165	COG1959	2 iron, 2 sulfur cluster binding
C1O51_11180	COG0352	thiamine-phosphate diphosphorylase activity
C1O51_11185	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
C1O51_11215	COG1703	isobutyryl-CoA mutase activity
C1O51_11235	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
C1O51_11245	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C1O51_11250	COG0418	dihydroorotase activity
C1O51_11265	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C1O51_11285	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C1O51_11315	COG0534	Mate efflux family protein
C1O51_11320	COG0489	protein tyrosine kinase activity
C1O51_11335	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C1O51_11345	COG0339	signal peptide processing
C1O51_11350	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C1O51_11360	COG1538	Outer membrane efflux protein
C1O51_11380	COG4112	unkown
C1O51_11395	COG0038	chloride channel
C1O51_11420	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
C1O51_11430	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C1O51_11435	COG0586	Pfam SNARE associated Golgi protein
C1O51_11505	COG1012	belongs to the aldehyde dehydrogenase family
C1O51_11525	COG0753	catalase activity
C1O51_11540	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
C1O51_11545	COG1592	Rubrerythrin
C1O51_11550	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C1O51_11560	COG1674	ftsk spoiiie
C1O51_11580	COG0489	protein tyrosine kinase activity
C1O51_11590	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
C1O51_11600	COG2244	polysaccharide biosynthetic process
C1O51_11605	COG1215	transferase activity, transferring glycosyl groups
C1O51_11615	COG1216	Glycosyl transferase, family 2
C1O51_11630	COG0438	transferase activity, transferring glycosyl groups
C1O51_11660	COG1216	Glycosyl transferase, family 2
C1O51_11705	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
C1O51_11710	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C1O51_11715	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
C1O51_11720	COG0280	phosphate acetyltransferase
C1O51_11720	COG0281	malic enzyme
C1O51_11735	COG1472	Belongs to the glycosyl hydrolase 3 family
C1O51_11765	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C1O51_11800	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
C1O51_11805	COG1063	alcohol dehydrogenase
C1O51_11820	COG0714	Associated with various cellular activities
C1O51_11830	COG0193	aminoacyl-tRNA hydrolase activity
C1O51_11835	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C1O51_11850	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
C1O51_11875	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
C1O51_11890	COG0375	protein maturation
C1O51_11925	COG0778	Nitroreductase
C1O51_11930	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C1O51_11965	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
C1O51_11965	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
C1O51_11985	COG3525	Glycosyl hydrolase, family 20, catalytic domain
C1O51_11990	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
C1O51_12015	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C1O51_12020	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C1O51_12035	COG0318	PFAM AMP-dependent synthetase and ligase
C1O51_12060	COG0339	signal peptide processing
C1O51_12070	COG0018	arginyl-trna synthetase
C1O51_12125	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
C1O51_12130	COG0653	protein targeting
C1O51_12150	COG0494	nUDIX hydrolase