locus-tag	class	description
CUB96_00065	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CUB96_00105	COG0191	fructose-bisphosphate aldolase activity
CUB96_00110	COG0019	diaminopimelate decarboxylase activity
CUB96_00115	COG0628	permease
CUB96_00125	COG0531	amino acid
CUB96_00130	COG2022	thiamine diphosphate biosynthetic process
CUB96_00140	COG4864	UPF0365 protein
CUB96_00145	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
CUB96_00155	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CUB96_00155	COG4651	solute:proton antiporter activity
CUB96_00160	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
CUB96_00165	COG0217	transcriptional regulatory protein
CUB96_00170	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
CUB96_00175	COG0602	queuosine metabolic process
CUB96_00185	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CUB96_00200	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
CUB96_00210	COG2855	membrane
CUB96_00215	COG0583	DNA-binding transcription factor activity
CUB96_00265	COG3118	belongs to the thioredoxin family
CUB96_00275	COG0017	Asparaginyl-tRNA synthetase
CUB96_00300	COG1733	regulation of RNA biosynthetic process
CUB96_00315	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CUB96_00325	COG1137	ATPase activity
CUB96_00340	COG2877	3-deoxy-8-phosphooctulonate synthase activity
CUB96_00355	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CUB96_00365	COG4608	Belongs to the ABC transporter superfamily
CUB96_00380	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CUB96_00390	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CUB96_00400	COG0066	3-isopropylmalate dehydratase activity
CUB96_00405	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CUB96_00410	COG0321	lipoyl(octanoyl) transferase activity
CUB96_00415	COG0860	N-Acetylmuramoyl-L-alanine amidase
CUB96_00420	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CUB96_00430	COG1181	Belongs to the D-alanine--D-alanine ligase family
CUB96_00435	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CUB96_00440	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CUB96_00445	COG0772	Belongs to the SEDS family
CUB96_00455	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CUB96_00460	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CUB96_00465	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CUB96_00470	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CUB96_00475	COG0768	penicillin binding
CUB96_00490	COG2001	Belongs to the MraZ family
CUB96_00495	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
CUB96_00500	COG2860	membrane
CUB96_00510	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CUB96_00515	COG0482	sulfurtransferase activity
CUB96_00525	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CUB96_00535	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
CUB96_00545	COG0438	transferase activity, transferring glycosyl groups
CUB96_00570	COG0463	Glycosyl transferase, family 2
CUB96_00570	COG1216	Glycosyl transferase, family 2
CUB96_00575	COG1215	transferase activity, transferring glycosyl groups
CUB96_00585	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
CUB96_00590	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CUB96_00595	COG2255	four-way junction helicase activity
CUB96_00645	COG2076	Multidrug Resistance protein
CUB96_00655	COG2226	methyltransferase
CUB96_00665	COG0631	protein serine/threonine phosphatase activity
CUB96_00670	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CUB96_00690	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
CUB96_00705	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
CUB96_00710	COG0708	Exodeoxyribonuclease III
CUB96_00745	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
CUB96_00755	COG0571	ribonuclease III activity
CUB96_00765	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CUB96_00775	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
CUB96_00800	COG2815	serine threonine protein kinase
CUB96_00800	COG0515	serine threonine protein kinase
CUB96_00805	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CUB96_00810	COG0424	maF-like protein
CUB96_00815	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CUB96_00835	COG3034	peptidoglycan biosynthetic process
CUB96_00840	COG0673	inositol 2-dehydrogenase activity
CUB96_00870	COG0612	Peptidase, M16
CUB96_00875	COG1663	tetraacyldisaccharide 4'-kinase activity
CUB96_00900	COG3956	TIGRFAM MazG family protein
CUB96_00910	COG1040	competence protein
CUB96_00945	COG0149	triose-phosphate isomerase activity
CUB96_00965	COG3119	arylsulfatase activity
CUB96_00970	COG0137	argininosuccinate synthase activity
CUB96_00985	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CUB96_00995	COG1253	flavin adenine dinucleotide binding
CUB96_01005	COG0792	nuclease activity
CUB96_01015	COG0134	indole-3-glycerol-phosphate synthase activity
CUB96_01040	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CUB96_01055	COG0848	biopolymer transport protein
CUB96_01080	COG1530	ribonuclease E activity
CUB96_01100	COG1363	Peptidase, m42
CUB96_01115	COG0047	phosphoribosylformylglycinamidine synthase activity
CUB96_01120	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CUB96_01130	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
CUB96_01140	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
CUB96_01150	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
CUB96_01155	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
CUB96_01160	COG1045	serine acetyltransferase
CUB96_01185	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CUB96_01240	COG0356	it plays a direct role in the translocation of protons across the membrane
CUB96_01250	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CUB96_01255	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CUB96_01260	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CUB96_01265	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CUB96_01270	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CUB96_01275	COG0355	proton-transporting ATP synthase activity, rotational mechanism
CUB96_01295	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CUB96_01340	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CUB96_01360	COG0719	Fe-S assembly protein
CUB96_01365	COG0719	Fe-S assembly protein
CUB96_01370	COG0396	ATPase activity
CUB96_01375	COG0396	ATPase activity
CUB96_01380	COG0735	belongs to the Fur family
CUB96_01385	COG0211	Belongs to the bacterial ribosomal protein bL27 family
CUB96_01395	COG0802	atpase or kinase
CUB96_01400	COG1073	alpha beta
CUB96_01410	COG5434	Belongs to the glycosyl hydrolase 28 family
CUB96_01425	COG2326	polyphosphate kinase activity
CUB96_01440	COG0742	ribosomal rna small subunit methyltransferase
CUB96_01460	COG1162	GTPase activity
CUB96_01465	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CUB96_01470	COG1104	cysteine desulfurase activity
CUB96_01485	COG1349	DNA-binding transcription factor activity
CUB96_01490	COG2326	polyphosphate kinase activity
CUB96_01510	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CUB96_01540	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
CUB96_01545	COG2259	Doxx family
CUB96_01570	COG3119	arylsulfatase activity
CUB96_01585	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CUB96_01585	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CUB96_01600	COG0012	GTP binding
CUB96_01605	COG1686	Belongs to the peptidase S11 family
CUB96_01610	COG0758	DNA mediated transformation
CUB96_01625	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
CUB96_01630	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CUB96_01635	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
CUB96_01640	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CUB96_01665	COG0456	acetyltransferase
CUB96_01675	COG1546	Belongs to the CinA family
CUB96_01675	COG1058	Belongs to the CinA family
CUB96_01695	COG0820	rRNA (adenine-C2-)-methyltransferase activity
CUB96_01700	COG0552	protein localization to endoplasmic reticulum
CUB96_01705	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CUB96_01715	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
CUB96_01720	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CUB96_01720	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CUB96_01725	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CUB96_01740	COG2814	Major facilitator Superfamily
CUB96_01755	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CUB96_01760	COG0828	Belongs to the bacterial ribosomal protein bS21 family
CUB96_01775	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
CUB96_01780	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
CUB96_01815	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CUB96_01825	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
CUB96_01830	COG1136	(ABC) transporter
CUB96_01850	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
CUB96_01855	COG3525	Glycosyl hydrolase, family 20, catalytic domain
CUB96_01870	COG4968	Prepilin-type N-terminal cleavage methylation domain
CUB96_01890	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CUB96_01895	COG0101	tRNA pseudouridine synthase activity
CUB96_01920	COG0110	maltose O-acetyltransferase activity
CUB96_01925	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
CUB96_01930	COG1185	polyribonucleotide nucleotidyltransferase activity
CUB96_01940	COG1253	flavin adenine dinucleotide binding
CUB96_01945	COG1253	flavin adenine dinucleotide binding
CUB96_01970	COG0352	thiamine-phosphate diphosphorylase activity
CUB96_01975	COG0167	dihydroorotate dehydrogenase activity
CUB96_01980	COG0587	DNA-directed DNA polymerase activity
CUB96_01995	COG0076	glutamate decarboxylase activity
CUB96_02010	COG3525	Glycosyl hydrolase, family 20, catalytic domain
CUB96_02020	COG0038	chloride channel
CUB96_02045	COG0300	oxidoreductase activity
CUB96_02055	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
CUB96_02075	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
CUB96_02135	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CUB96_02140	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CUB96_02145	COG0799	negative regulation of ribosome biogenesis
CUB96_02155	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CUB96_02215	COG1136	(ABC) transporter
CUB96_02215	COG0577	efflux transmembrane transporter activity
CUB96_02285	COG0444	Belongs to the ABC transporter superfamily
CUB96_02295	COG0795	lipopolysaccharide-transporting ATPase activity
CUB96_02310	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CUB96_02315	COG1722	exodeoxyribonuclease VII activity
CUB96_02325	COG2204	response regulator
CUB96_02330	COG3852	Histidine kinase
CUB96_02340	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
CUB96_02345	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CUB96_02350	COG0049	tRNA binding
CUB96_02355	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CUB96_02360	COG0051	transcription antitermination factor activity, RNA binding
CUB96_02365	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CUB96_02370	COG0088	Forms part of the polypeptide exit tunnel
CUB96_02375	COG0089	rRNA binding
CUB96_02380	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CUB96_02385	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CUB96_02395	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
CUB96_02400	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CUB96_02405	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CUB96_02410	COG0255	Belongs to the universal ribosomal protein uL29 family
CUB96_02415	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CUB96_02420	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
CUB96_02440	COG3250	beta-galactosidase activity
CUB96_02460	COG0811	peptide transport
CUB96_02495	COG0776	regulation of translation
CUB96_02500	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CUB96_02505	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
CUB96_02515	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CUB96_02520	COG0343	queuine tRNA-ribosyltransferase activity
CUB96_02525	COG1862	Preprotein translocase
CUB96_02550	COG0228	four-way junction DNA binding
CUB96_02555	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CUB96_02560	COG0009	L-threonylcarbamoyladenylate synthase
CUB96_02565	COG0537	adenosine 5'-monophosphoramidase activity
CUB96_02575	COG0333	Belongs to the bacterial ribosomal protein bL32 family
CUB96_02580	COG0416	fatty acid biosynthetic process
CUB96_02590	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
CUB96_02590	COG0662	Cupin 2, conserved barrel domain protein
CUB96_02615	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CUB96_02655	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CUB96_02660	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
CUB96_02665	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
CUB96_02670	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
CUB96_02720	COG0539	negative regulation of cytoplasmic translation
CUB96_02730	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
CUB96_02735	COG0336	Belongs to the RNA methyltransferase TrmD family
CUB96_02745	COG1187	pseudouridine synthase activity
CUB96_02765	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
CUB96_02770	COG1393	Belongs to the ArsC family
CUB96_02775	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CUB96_02785	COG1063	alcohol dehydrogenase
CUB96_02790	COG0242	peptide deformylase activity
CUB96_02800	COG1028	Short-chain dehydrogenase reductase Sdr
CUB96_02865	COG0351	phosphomethylpyrimidine kinase
CUB96_02875	COG0471	metal ion transport
CUB96_02890	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CUB96_02910	COG0028	Belongs to the TPP enzyme family
CUB96_02915	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CUB96_02925	COG0205	6-phosphofructokinase activity
CUB96_02935	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
CUB96_02945	COG0427	acetyl-CoA hydrolase
CUB96_02950	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
CUB96_02950	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
CUB96_02955	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
CUB96_02960	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
CUB96_02975	COG0346	lactoylglutathione lyase activity
CUB96_02985	COG0335	large ribosomal subunit rRNA binding
CUB96_03000	COG2267	carboxylic ester hydrolase activity
CUB96_03005	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CUB96_03025	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
CUB96_03030	COG0657	acetylesterase activity
CUB96_03030	COG2755	lipolytic protein G-D-S-L family
CUB96_03035	COG2234	aminopeptidase activity
CUB96_03055	COG4591	ABC-type transport system involved in lipoprotein release permease component
CUB96_03065	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CUB96_03070	COG0546	phosphoglycolate phosphatase activity
CUB96_03075	COG1322	Protein conserved in bacteria
CUB96_03085	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CUB96_03110	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CUB96_03135	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CUB96_03165	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
CUB96_03170	COG1127	ABC transporter
CUB96_03185	COG1132	(ABC) transporter
CUB96_03190	COG1132	(ABC) transporter
CUB96_03195	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CUB96_03255	COG0601	transmembrane transport
CUB96_03260	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CUB96_03315	COG1475	DNA binding
CUB96_03380	COG1918	ferrous iron import across plasma membrane
CUB96_03380	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
CUB96_03390	COG3119	arylsulfatase activity
CUB96_03400	COG0750	zinc metalloprotease
CUB96_03410	COG2957	Belongs to the agmatine deiminase family
CUB96_03415	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
CUB96_03435	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
CUB96_03440	COG0540	Belongs to the ATCase OTCase family
CUB96_03445	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CUB96_03450	COG1720	tRNA m6t6A37 methyltransferase activity
CUB96_03460	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CUB96_03485	COG0577	efflux transmembrane transporter activity
CUB96_03485	COG1136	(ABC) transporter
CUB96_03490	COG0577	efflux transmembrane transporter activity
CUB96_03490	COG1136	(ABC) transporter
CUB96_03495	COG1566	PFAM secretion protein HlyD family protein
CUB96_03500	COG0494	nUDIX hydrolase
CUB96_03515	COG1940	carbohydrate kinase activity
CUB96_03520	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
CUB96_03525	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CUB96_03530	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CUB96_03535	COG1469	GTP cyclohydrolase I activity
CUB96_03545	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
CUB96_03550	COG0181	hydroxymethylbilane synthase activity
CUB96_03560	COG3189	MarR family transcriptional regulator
CUB96_03575	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
CUB96_03615	COG3266	domain, Protein
CUB96_03615	COG0515	serine threonine protein kinase
CUB96_03620	COG1192	Involved in chromosome partitioning
CUB96_03635	COG0156	8-amino-7-oxononanoate synthase activity
CUB96_03650	COG2816	NAD+ diphosphatase activity
CUB96_03655	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CUB96_03670	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
CUB96_03680	COG1692	metallophosphoesterase
CUB96_03690	COG0180	Tryptophanyl-tRNA synthetase
CUB96_03700	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
CUB96_03700	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
CUB96_03715	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CUB96_03720	COG0179	Fumarylacetoacetate (FAA) hydrolase
CUB96_03755	COG0542	response to heat
CUB96_03760	COG3869	Catalyzes the specific phosphorylation of arginine residues in
CUB96_03765	COG3880	PFAM UvrB UvrC protein
CUB96_03775	COG1121	(ABC) transporter
CUB96_03795	COG3525	Glycosyl hydrolase, family 20, catalytic domain
CUB96_03810	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CUB96_03815	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CUB96_03820	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CUB96_03825	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CUB96_03835	COG0534	Mate efflux family protein
CUB96_03840	COG2226	methyltransferase
CUB96_03860	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
CUB96_03870	COG2890	protein-(glutamine-N5) methyltransferase activity
CUB96_03875	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CUB96_03885	COG1115	amino acid carrier protein
CUB96_03900	COG2066	Belongs to the glutaminase family
CUB96_03905	COG0531	amino acid
CUB96_03930	COG0442	prolyl-tRNA aminoacylation
CUB96_03955	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CUB96_03985	COG1971	Probably functions as a manganese efflux pump
CUB96_04000	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
CUB96_04020	COG0673	inositol 2-dehydrogenase activity
CUB96_04035	COG0513	Belongs to the DEAD box helicase family
CUB96_04045	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CUB96_04050	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CUB96_04065	COG0564	pseudouridine synthase activity
CUB96_04070	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
CUB96_04090	COG1131	(ABC) transporter
CUB96_04095	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CUB96_04100	COG0494	nUDIX hydrolase
CUB96_04120	COG0653	protein targeting
CUB96_04165	COG0018	arginyl-trna synthetase
CUB96_04175	COG0339	signal peptide processing
CUB96_04210	COG0318	PFAM AMP-dependent synthetase and ligase
CUB96_04225	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CUB96_04230	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CUB96_04270	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CUB96_04275	COG3525	Glycosyl hydrolase, family 20, catalytic domain
CUB96_04295	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
CUB96_04295	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
CUB96_04305	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CUB96_04305	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CUB96_04320	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CUB96_04325	COG0778	Nitroreductase
CUB96_04360	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
CUB96_04385	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CUB96_04400	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CUB96_04405	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CUB96_04415	COG0193	aminoacyl-tRNA hydrolase activity
CUB96_04425	COG0714	Associated with various cellular activities
CUB96_04440	COG1063	alcohol dehydrogenase
CUB96_04445	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CUB96_04455	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CUB96_04475	COG1472	Belongs to the glycosyl hydrolase 3 family
CUB96_04490	COG0280	phosphate acetyltransferase
CUB96_04490	COG0281	malic enzyme
CUB96_04505	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
CUB96_04510	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CUB96_04510	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CUB96_04515	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
CUB96_04565	COG1216	Glycosyl transferase, family 2
CUB96_04575	COG0110	maltose O-acetyltransferase activity
CUB96_04615	COG0438	transferase activity, transferring glycosyl groups
CUB96_04625	COG0438	transferase activity, transferring glycosyl groups
CUB96_04635	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CUB96_04645	COG0489	protein tyrosine kinase activity
CUB96_04655	COG1674	ftsk spoiiie
CUB96_04665	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CUB96_04675	COG1592	Rubrerythrin
CUB96_04680	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CUB96_04695	COG0753	catalase activity
CUB96_04715	COG1012	belongs to the aldehyde dehydrogenase family
CUB96_04795	COG0586	Pfam SNARE associated Golgi protein
CUB96_04800	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CUB96_04805	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CUB96_04825	COG0038	chloride channel
CUB96_04850	COG1538	Outer membrane efflux protein
CUB96_04860	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CUB96_04865	COG0339	signal peptide processing
CUB96_04870	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CUB96_04885	COG0489	protein tyrosine kinase activity
CUB96_04890	COG0534	Mate efflux family protein
CUB96_04905	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CUB96_04910	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
CUB96_04925	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CUB96_04945	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CUB96_04955	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
CUB96_04975	COG1703	isobutyryl-CoA mutase activity
CUB96_05005	COG0352	thiamine-phosphate diphosphorylase activity
CUB96_05020	COG1959	2 iron, 2 sulfur cluster binding
CUB96_05025	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CUB96_05045	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
CUB96_05065	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CUB96_05070	COG0326	Molecular chaperone. Has ATPase activity
CUB96_05100	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CUB96_05100	COG0072	phenylalanine-tRNA ligase activity
CUB96_05105	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CUB96_05105	COG0072	phenylalanine-tRNA ligase activity
CUB96_05110	COG0072	phenylalanine-tRNA ligase activity
CUB96_05110	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CUB96_05115	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CUB96_05115	COG0072	phenylalanine-tRNA ligase activity
CUB96_05130	COG3033	Beta-eliminating lyase
CUB96_05150	COG2818	Glycosylase
CUB96_05155	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CUB96_05185	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CUB96_05185	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CUB96_05205	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
CUB96_05215	COG0166	Belongs to the GPI family
CUB96_05225	COG0574	Belongs to the PEP-utilizing enzyme family
CUB96_05225	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CUB96_05230	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
CUB96_05235	COG1194	a g-specific adenine glycosylase
CUB96_05240	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CUB96_05265	COG5522	Integral membrane protein (intg_mem_TP0381)
CUB96_05285	COG0460	homoserine dehydrogenase
CUB96_05295	COG3610	response to peptide
CUB96_05300	COG2966	Psort location CytoplasmicMembrane, score
CUB96_05340	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CUB96_05345	COG0519	Catalyzes the synthesis of GMP from XMP
CUB96_05345	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CUB96_05370	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CUB96_05410	COG2195	Cleaves the N-terminal amino acid of tripeptides
CUB96_05415	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CUB96_05435	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CUB96_05435	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CUB96_05470	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CUB96_05475	COG4605	iron ion homeostasis
CUB96_05480	COG4604	ABC transporter, ATP-binding protein
CUB96_05485	COG4607	ABC-type enterochelin transport system periplasmic component
CUB96_05495	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CUB96_05535	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
CUB96_05540	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CUB96_05540	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
CUB96_05555	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CUB96_05570	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
CUB96_05580	COG1454	alcohol dehydrogenase
CUB96_05605	COG4974	Belongs to the 'phage' integrase family
CUB96_05630	COG1408	metallophosphoesterase
CUB96_05640	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
CUB96_05650	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
CUB96_05660	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CUB96_05670	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CUB96_05690	COG1968	undecaprenyl-diphosphatase activity
CUB96_05695	COG0805	protein transport
CUB96_05700	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CUB96_05700	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
CUB96_05705	COG0668	transmembrane transport
CUB96_05715	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
CUB96_05720	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CUB96_05725	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CUB96_05735	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
CUB96_05755	COG0538	isocitrate dehydrogenase activity
CUB96_05760	COG3274	enterobacterial common antigen metabolic process
CUB96_05775	COG3258	Cytochrome c
CUB96_05785	COG2010	Cytochrome c
CUB96_05820	COG0242	peptide deformylase activity
CUB96_05830	COG0811	peptide transport
CUB96_05845	COG0151	Belongs to the GarS family
CUB96_05850	COG3738	Protein conserved in bacteria
CUB96_05855	COG2759	Belongs to the formate--tetrahydrofolate ligase family
CUB96_05860	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
CUB96_05880	COG0601	transmembrane transport
CUB96_05885	COG4239	(ABC) transporter, permease
CUB96_05895	COG4166	transmembrane transport
CUB96_05900	COG0444	Belongs to the ABC transporter superfamily
CUB96_05905	COG4608	Belongs to the ABC transporter superfamily
CUB96_05910	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CUB96_05935	COG0232	Belongs to the dGTPase family. Type 2 subfamily
CUB96_05955	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CUB96_05975	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
CUB96_06000	COG1595	DNA-templated transcription, initiation
CUB96_06015	COG0738	Major facilitator superfamily
CUB96_06035	COG1070	Carbohydrate kinase
CUB96_06085	COG0363	glucosamine-6-phosphate deaminase activity
CUB96_06090	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
CUB96_06100	COG1837	Belongs to the UPF0109 family
CUB96_06115	COG1091	dTDP-4-dehydrorhamnose reductase activity
CUB96_06135	COG0534	Mate efflux family protein
CUB96_06155	COG0789	Transcriptional regulator
CUB96_06160	COG2249	NAD(P)H dehydrogenase (quinone) activity
CUB96_06170	COG0667	Aldo Keto reductase
CUB96_06190	COG1408	metallophosphoesterase
CUB96_06195	COG0667	Aldo Keto reductase
CUB96_06205	COG0656	L-ascorbic acid biosynthetic process
CUB96_06215	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
CUB96_06245	COG2755	lipolytic protein G-D-S-L family
CUB96_06245	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
CUB96_06260	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CUB96_06265	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CUB96_06305	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CUB96_06310	COG0154	amidase activity
CUB96_06315	COG0714	Associated with various cellular activities
CUB96_06350	COG0656	L-ascorbic acid biosynthetic process
CUB96_06355	COG0423	glycine-tRNA ligase activity
CUB96_06370	COG0436	Aminotransferase
CUB96_06375	COG1522	sequence-specific DNA binding
CUB96_06385	COG2967	ApaG domain
CUB96_06410	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CUB96_06425	COG1131	(ABC) transporter
CUB96_06430	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CUB96_06435	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
CUB96_06440	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CUB96_06445	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CUB96_06455	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CUB96_06460	COG2166	iron-sulfur cluster assembly
CUB96_06470	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
CUB96_06475	COG3475	LICD family
CUB96_06485	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CUB96_06495	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
CUB96_06500	COG3475	LICD family
CUB96_06540	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
CUB96_06560	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CUB96_06575	COG0113	porphobilinogen synthase activity
CUB96_06585	COG0745	RESPONSE REGULATOR receiver
CUB96_06590	COG0745	RESPONSE REGULATOR receiver
CUB96_06595	COG2205	protein histidine kinase activity
CUB96_06600	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CUB96_06675	COG0045	succinate-CoA ligase (ADP-forming) activity
CUB96_06680	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
CUB96_06695	COG0514	ATP-dependent DNA helicase (RecQ)
CUB96_06730	COG2949	membrane
CUB96_06755	COG1846	Transcriptional regulator
CUB96_06775	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CUB96_06785	COG1271	oxidase subunit
CUB96_06790	COG1294	oxidase, subunit
CUB96_06815	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CUB96_06820	COG0402	S-adenosylhomocysteine deaminase activity
CUB96_06840	COG4771	TonB-dependent receptor
CUB96_06855	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
CUB96_06860	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
CUB96_06910	COG0205	6-phosphofructokinase activity
CUB96_06930	COG3525	Glycosyl hydrolase, family 20, catalytic domain
CUB96_06935	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CUB96_06940	COG3250	beta-galactosidase activity
CUB96_06945	COG3250	beta-galactosidase activity
CUB96_07000	COG3119	arylsulfatase activity
CUB96_07010	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CUB96_07015	COG0688	phosphatidylethanolamine metabolic process
CUB96_07025	COG0028	Belongs to the TPP enzyme family
CUB96_07030	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CUB96_07035	COG0268	Binds directly to 16S ribosomal RNA
CUB96_07045	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
CUB96_07050	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CUB96_07070	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CUB96_07085	COG1450	Type ii and iii secretion system protein
CUB96_07115	COG1643	Atp-dependent helicase
CUB96_07130	COG0793	Belongs to the peptidase S41A family
CUB96_07135	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CUB96_07150	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
CUB96_07155	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CUB96_07160	COG0358	DNA primase activity
CUB96_07165	COG1030	water channel activity
CUB96_07170	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CUB96_07185	COG1640	4-alpha-glucanotransferase
CUB96_07190	COG3210	domain, Protein
CUB96_07200	COG2264	protein methyltransferase activity
CUB96_07210	COG0307	riboflavin synthase, alpha
CUB96_07225	COG0726	polysaccharide deacetylase
CUB96_07240	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
CUB96_07250	COG1034	ATP synthesis coupled electron transport
CUB96_07255	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
CUB96_07265	COG0839	Belongs to the complex I subunit 6 family
CUB96_07270	COG0713	ATP synthesis coupled electron transport
CUB96_07285	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CUB96_07290	COG1007	ATP synthesis coupled electron transport
CUB96_07320	COG0142	geranyltranstransferase activity
CUB96_07325	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
CUB96_07330	COG0037	tRNA processing
CUB96_07335	COG1691	(AIR) carboxylase
CUB96_07340	COG1649	PFAM Uncharacterised BCR, COG1649
CUB96_07355	COG0728	peptidoglycan biosynthetic process
CUB96_07370	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CUB96_07380	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CUB96_07385	COG1459	type II secretion system
CUB96_07395	COG0463	Glycosyl transferase, family 2
CUB96_07400	COG1215	transferase activity, transferring glycosyl groups
CUB96_07405	COG0105	UTP biosynthetic process
CUB96_07415	COG1187	pseudouridine synthase activity
CUB96_07425	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
CUB96_07440	COG0372	Belongs to the citrate synthase family
CUB96_07465	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CUB96_07475	COG1979	alcohol dehydrogenase
CUB96_07480	COG2373	Large extracellular alpha-helical protein
CUB96_07495	COG0697	spore germination
CUB96_07510	COG1074	ATP-dependent DNA helicase activity
CUB96_07525	COG0750	zinc metalloprotease
CUB96_07530	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
CUB96_07535	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CUB96_07540	COG0556	nucleotide-excision repair
CUB96_07560	COG2223	nitrite transmembrane transporter activity
CUB96_07565	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CUB96_07575	COG0561	phosphatase activity
CUB96_07605	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
CUB96_07615	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CUB96_07620	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CUB96_07640	COG0159	tryptophan synthase activity
CUB96_07655	COG0134	indole-3-glycerol-phosphate synthase activity
CUB96_07665	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CUB96_07685	COG0667	Aldo Keto reductase
CUB96_07730	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CUB96_07765	COG2885	chlorophyll binding
CUB96_07780	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CUB96_07790	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
CUB96_07795	COG0203	ribosomal protein L17
CUB96_07800	COG0202	RNA polymerase activity
CUB96_07820	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CUB96_07820	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CUB96_07825	COG0726	polysaccharide deacetylase
CUB96_07860	COG1575	Belongs to the MenA family. Type 1 subfamily
CUB96_07875	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CUB96_07880	COG0471	metal ion transport
CUB96_07880	COG3273	potassium ion transport
CUB96_07890	COG1561	YicC-like family, N-terminal region
CUB96_07895	COG3977	Valine--pyruvate aminotransferase
CUB96_07910	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CUB96_07915	COG0428	transporter
CUB96_07925	COG0205	6-phosphofructokinase activity
CUB96_07930	COG1686	Belongs to the peptidase S11 family
CUB96_07945	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
CUB96_07950	COG0360	Binds together with S18 to 16S ribosomal RNA
CUB96_07955	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
CUB96_07960	COG0131	Imidazoleglycerol-phosphate dehydratase
CUB96_07975	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
CUB96_07980	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CUB96_08005	COG0277	FAD linked oxidase domain protein
CUB96_08020	COG5434	Belongs to the glycosyl hydrolase 28 family
CUB96_08030	COG1385	rRNA (uridine-N3-)-methyltransferase activity
CUB96_08035	COG0484	heat shock protein binding
CUB96_08045	COG1872	DUF167
CUB96_08050	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
CUB96_08075	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CUB96_08095	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
CUB96_08100	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
CUB96_08110	COG0765	amino acid transport
CUB96_08115	COG1126	abc transporter atp-binding protein
CUB96_08140	COG0564	pseudouridine synthase activity
CUB96_08145	COG0778	Nitroreductase
CUB96_08170	COG0039	L-malate dehydrogenase activity
CUB96_08175	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
CUB96_08210	COG0254	rRNA binding
CUB96_08215	COG0037	tRNA processing
CUB96_08225	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
CUB96_08240	COG2271	Major facilitator Superfamily
CUB96_08250	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CUB96_08255	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CUB96_08265	COG1082	Xylose isomerase domain protein TIM barrel
CUB96_08280	COG0126	phosphoglycerate kinase activity
CUB96_08290	COG0632	four-way junction helicase activity
CUB96_08350	COG0459	protein refolding
CUB96_08355	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CUB96_08360	COG0443	Heat shock 70 kDa protein
CUB96_08365	COG0438	transferase activity, transferring glycosyl groups
CUB96_08395	COG0298	carbon dioxide binding
CUB96_08400	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
CUB96_08405	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
CUB96_08410	COG0124	histidyl-tRNA synthetase
CUB96_08415	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CUB96_08445	COG0156	8-amino-7-oxononanoate synthase activity
CUB96_08470	COG1028	Short-chain dehydrogenase reductase Sdr
CUB96_08475	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
CUB96_08485	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CUB96_08495	COG1183	phosphatidylcholine synthase activity
CUB96_08500	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CUB96_08510	COG1131	(ABC) transporter
CUB96_08515	COG0842	Transport permease protein
CUB96_08520	COG0842	Transport permease protein
CUB96_08535	COG0305	Participates in initiation and elongation during chromosome replication
CUB96_08765	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CUB96_08770	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CUB96_08775	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CUB96_08810	COG0733	neurotransmitter:sodium symporter activity
CUB96_08815	COG0450	alkyl hydroperoxide reductase
CUB96_08820	COG0668	transmembrane transport
CUB96_08825	COG0528	UMP kinase activity
CUB96_08830	COG0233	cytoplasmic translational termination
CUB96_08865	COG0612	Peptidase, M16
CUB96_08880	COG2017	converts alpha-aldose to the beta-anomer
CUB96_08890	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CUB96_08900	COG0573	inorganic phosphate transmembrane transporter activity
CUB96_08925	COG0175	sulfate reduction
CUB96_08930	COG0175	sulfate reduction
CUB96_08950	COG1116	anion transmembrane transporter activity
CUB96_08960	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CUB96_08980	COG1262	PFAM Formylglycine-generating sulfatase enzyme
CUB96_08995	COG0826	peptidase U32
CUB96_09005	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CUB96_09010	COG0187	DNA topoisomerase II activity
CUB96_09025	COG0545	Peptidyl-prolyl cis-trans isomerase
CUB96_09035	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
CUB96_09045	COG1408	metallophosphoesterase
CUB96_09100	COG0492	ferredoxin-NADP+ reductase activity
CUB96_09100	COG3118	belongs to the thioredoxin family
CUB96_09105	COG1760	l-serine dehydratase
CUB96_09120	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CUB96_09140	COG0676	glucose-6-phosphate 1-epimerase activity
CUB96_09150	COG2755	lipolytic protein G-D-S-L family
CUB96_09150	COG0657	acetylesterase activity
CUB96_09165	COG0230	Belongs to the bacterial ribosomal protein bL34 family
CUB96_09175	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
CUB96_09180	COG0706	membrane insertase activity
CUB96_09190	COG0069	glutamate synthase activity
CUB96_09190	COG0067	glutamate synthase
CUB96_09190	COG0070	glutamate synthase
CUB96_09205	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CUB96_09210	COG0505	Belongs to the CarA family
CUB96_09215	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
CUB96_09220	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CUB96_09225	COG1757	Na H antiporter
CUB96_09235	COG1482	cell wall glycoprotein biosynthetic process
CUB96_09245	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
CUB96_09255	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
CUB96_09265	COG0848	biopolymer transport protein
CUB96_09270	COG0811	peptide transport
CUB96_09275	COG0322	excinuclease ABC activity
CUB96_09280	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
CUB96_09285	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
CUB96_09290	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CUB96_09295	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CUB96_09300	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
CUB96_09300	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CUB96_09305	COG2003	Belongs to the UPF0758 family
CUB96_09325	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CUB96_09330	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
CUB96_09350	COG0284	orotidine-5'-phosphate decarboxylase activity
CUB96_09410	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CUB96_09430	COG0437	4 iron, 4 sulfur cluster binding
CUB96_09440	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CUB96_09445	COG3409	Peptidoglycan-binding domain 1 protein
CUB96_09445	COG5632	N-Acetylmuramoyl-L-alanine amidase
CUB96_09450	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
CUB96_09460	COG0736	holo-[acyl-carrier-protein] synthase activity
CUB96_09465	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
CUB96_09470	COG0138	bifunctional purine biosynthesis protein purh
CUB96_09475	COG0359	binds to the 23S rRNA
CUB96_09485	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CUB96_09510	COG1122	ATPase activity
CUB96_09515	COG1199	ATP-dependent helicase activity
CUB96_09525	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
CUB96_09545	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CUB96_09560	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CUB96_09575	COG1477	protein flavinylation
CUB96_09585	COG0148	phosphopyruvate hydratase activity
CUB96_09605	COG2186	Transcriptional regulator
CUB96_09610	COG1119	ATPase activity
CUB96_09615	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
CUB96_09630	COG1090	epimerase
CUB96_09655	COG2311	Membrane
CUB96_09660	COG0714	Associated with various cellular activities
CUB96_09710	COG0789	Transcriptional regulator
CUB96_09715	COG0667	Aldo Keto reductase
CUB96_09730	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CUB96_09750	COG2205	protein histidine kinase activity
CUB96_09755	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
CUB96_09760	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
CUB96_09800	COG3209	COG3209 Rhs family protein
CUB96_09845	COG1876	peptidase activity
CUB96_09860	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CUB96_09865	COG0534	Mate efflux family protein
CUB96_09890	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CUB96_09895	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CUB96_09930	COG1368	sulfuric ester hydrolase activity
CUB96_09955	COG0129	dihydroxy-acid dehydratase activity
CUB96_09960	COG0745	RESPONSE REGULATOR receiver
CUB96_09985	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
CUB96_09990	COG0006	proline dipeptidase activity
CUB96_10005	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
CUB96_10010	COG1363	Peptidase, m42
CUB96_10040	COG0237	dephospho-CoA kinase activity
CUB96_10045	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
CUB96_10050	COG2217	Heavy metal translocating P-type atpase
CUB96_10055	COG2217	Heavy metal translocating P-type atpase
CUB96_10060	COG1940	carbohydrate kinase activity
CUB96_10065	COG0590	tRNA wobble adenosine to inosine editing
CUB96_10070	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
CUB96_10075	COG1858	cytochrome C peroxidase
CUB96_10090	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
CUB96_10135	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CUB96_10140	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
CUB96_10160	COG0514	ATP-dependent DNA helicase (RecQ)
CUB96_10165	COG3119	arylsulfatase activity
CUB96_10175	COG0446	pyridine nucleotide-disulphide oxidoreductase
CUB96_10175	COG1902	pentaerythritol trinitrate reductase activity
CUB96_10195	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
CUB96_10200	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CUB96_10205	COG2226	methyltransferase
CUB96_10250	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CUB96_10270	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
CUB96_10285	COG0544	peptidyl-prolyl cis-trans isomerase activity
CUB96_10290	COG0740	serine-type endopeptidase activity
CUB96_10300	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CUB96_10310	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CUB96_10325	COG0250	Participates in transcription elongation, termination and antitermination
CUB96_10330	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
CUB96_10335	COG0081	regulation of translation
CUB96_10340	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
CUB96_10345	COG0222	ribosome binding
CUB96_10350	COG0085	RNA polymerase activity
CUB96_10355	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CUB96_10370	COG0481	GTPase activity
CUB96_10380	COG3119	arylsulfatase activity
CUB96_10390	COG0215	cysteine-tRNA ligase activity
CUB96_10400	COG0697	spore germination
CUB96_10410	COG0488	(ABC) transporter
CUB96_10455	COG2095	MarC family integral membrane protein
CUB96_10460	COG2267	carboxylic ester hydrolase activity
CUB96_10525	COG1073	alpha beta
CUB96_10535	COG1028	Short-chain dehydrogenase reductase Sdr
CUB96_10540	COG1253	flavin adenine dinucleotide binding
CUB96_10555	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
CUB96_10625	COG1053	succinate dehydrogenase
CUB96_10630	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CUB96_10660	COG1490	D-aminoacyl-tRNA deacylase activity
CUB96_10675	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CUB96_10680	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
CUB96_10690	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CUB96_10710	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CUB96_10715	COG0724	RNA recognition motif
CUB96_10735	COG1716	ATPase activity
CUB96_10735	COG1131	(ABC) transporter
CUB96_10735	COG0842	Transport permease protein
CUB96_10750	COG2006	4fe-4S ferredoxin, iron-sulfur binding domain protein
CUB96_10755	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
CUB96_10760	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CUB96_10765	COG0708	Exodeoxyribonuclease III
CUB96_10770	COG0195	Participates in both transcription termination and antitermination
CUB96_10775	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
CUB96_10780	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
CUB96_10785	COG3119	arylsulfatase activity
CUB96_10795	COG1966	Carbon starvation protein
CUB96_10805	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CUB96_10810	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
CUB96_10815	COG0508	dehydrogenase complex catalyzes the overall conversion of
CUB96_10820	COG0693	protein deglycase activity
CUB96_10825	COG1216	Glycosyl transferase, family 2
CUB96_10840	COG1216	Glycosyl transferase, family 2
CUB96_10850	COG1216	Glycosyl transferase, family 2
CUB96_10860	COG1442	glycosyl transferase family 8
CUB96_10870	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
CUB96_10885	COG0024	Methionine aminopeptidase
CUB96_10890	COG0563	adenylate kinase activity
CUB96_10895	COG0201	protein transport
CUB96_10900	COG0200	Binds to the 23S rRNA
CUB96_10905	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CUB96_10910	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
CUB96_10915	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
CUB96_10920	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
CUB96_10930	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
CUB96_10935	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CUB96_10945	COG0737	Belongs to the 5'-nucleotidase family
CUB96_10955	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CUB96_10960	COG0673	inositol 2-dehydrogenase activity
CUB96_10975	COG0285	dihydrofolate synthase activity
CUB96_10980	COG0285	dihydrofolate synthase activity
CUB96_10985	COG0826	peptidase U32
CUB96_10995	COG0557	exoribonuclease II activity
CUB96_11005	COG2096	Adenosyltransferase
CUB96_11015	COG2814	Major facilitator Superfamily
CUB96_11025	COG1690	Belongs to the RtcB family
CUB96_11050	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
CUB96_11055	COG3409	Peptidoglycan-binding domain 1 protein
CUB96_11055	COG5632	N-Acetylmuramoyl-L-alanine amidase
CUB96_11120	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CUB96_11125	COG0789	Transcriptional regulator
CUB96_11135	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CUB96_11180	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
CUB96_11185	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
CUB96_11185	COG0321	lipoyl(octanoyl) transferase activity
CUB96_11190	COG0497	DNA recombination
CUB96_11195	COG2217	Heavy metal translocating P-type atpase
CUB96_11215	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CUB96_11220	COG1970	mechanosensitive ion channel activity
CUB96_11225	COG1785	Belongs to the alkaline phosphatase family
CUB96_11230	COG3525	Glycosyl hydrolase, family 20, catalytic domain
CUB96_11235	COG1363	Peptidase, m42
CUB96_11245	COG1592	Rubrerythrin
CUB96_11255	COG2194	sulfuric ester hydrolase activity
CUB96_11285	COG0471	metal ion transport
CUB96_11330	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CUB96_11335	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CUB96_11345	COG3481	metal-dependent phosphohydrolase, HD sub domain
CUB96_11355	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
CUB96_11360	COG0148	phosphopyruvate hydratase activity
CUB96_11375	COG0165	Argininosuccinate lyase
CUB96_11380	COG0659	secondary active sulfate transmembrane transporter activity
CUB96_11390	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CUB96_11440	COG0542	response to heat
CUB96_11470	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
CUB96_11480	COG0745	RESPONSE REGULATOR receiver
CUB96_11485	COG2205	protein histidine kinase activity
CUB96_11500	COG3250	beta-galactosidase activity
CUB96_11510	COG0084	hydrolase, TatD family'
CUB96_11515	COG0791	NLP P60 protein
CUB96_11515	COG1388	LysM domain
CUB96_11540	COG0592	DNA-directed DNA polymerase activity
CUB96_11550	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CUB96_11555	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CUB96_11555	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CUB96_11580	COG0440	acetolactate synthase activity
CUB96_11585	COG1643	Atp-dependent helicase
CUB96_11595	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CUB96_11605	COG0107	imidazoleglycerol-phosphate synthase activity
CUB96_11620	COG1733	regulation of RNA biosynthetic process
CUB96_11640	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CUB96_11650	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
CUB96_11655	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CUB96_11670	COG0535	radical SAM domain protein
CUB96_11705	COG0473	3-isopropylmalate dehydrogenase activity
CUB96_11715	COG3969	phosphoadenosine phosphosulfate
CUB96_11720	COG1475	DNA binding
CUB96_11735	COG1525	nuclease
CUB96_11745	COG1028	Short-chain dehydrogenase reductase Sdr
CUB96_11755	COG1607	acyl-coa hydrolase
CUB96_11760	COG0477	Major facilitator Superfamily
CUB96_11770	COG0588	phosphoglycerate mutase activity
CUB96_11820	COG0471	metal ion transport
CUB96_11820	COG0490	domain, Protein
CUB96_11835	COG2755	lipolytic protein G-D-S-L family
CUB96_11835	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
CUB96_11855	COG1216	Glycosyl transferase, family 2
CUB96_11860	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CUB96_11870	COG1442	glycosyl transferase family 8
CUB96_11870	COG1216	Glycosyl transferase, family 2
CUB96_11880	COG1408	metallophosphoesterase
CUB96_11895	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CUB96_11900	COG0196	riboflavin kinase activity
CUB96_11905	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
CUB96_11920	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
CUB96_11940	COG0546	phosphoglycolate phosphatase activity
CUB96_11950	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CUB96_11950	COG0519	Catalyzes the synthesis of GMP from XMP