locus-tag	class	description
CUC01_00120	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CUC01_00125	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CUC01_00130	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CUC01_00155	COG0733	neurotransmitter:sodium symporter activity
CUC01_00160	COG0450	alkyl hydroperoxide reductase
CUC01_00165	COG0668	transmembrane transport
CUC01_00170	COG0528	UMP kinase activity
CUC01_00175	COG0233	cytoplasmic translational termination
CUC01_00210	COG0612	Peptidase, M16
CUC01_00225	COG2017	converts alpha-aldose to the beta-anomer
CUC01_00235	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CUC01_00245	COG0573	inorganic phosphate transmembrane transporter activity
CUC01_00250	COG0581	inorganic phosphate transmembrane transporter activity
CUC01_00270	COG0175	sulfate reduction
CUC01_00275	COG0175	sulfate reduction
CUC01_00280	COG0529	Catalyzes the synthesis of activated sulfate
CUC01_00280	COG2895	sulfate adenylyltransferase (ATP) activity
CUC01_00290	COG1116	anion transmembrane transporter activity
CUC01_00300	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CUC01_00325	COG1262	PFAM Formylglycine-generating sulfatase enzyme
CUC01_00335	COG0826	peptidase U32
CUC01_00350	COG0187	DNA topoisomerase II activity
CUC01_00365	COG0545	Peptidyl-prolyl cis-trans isomerase
CUC01_00370	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
CUC01_00380	COG1408	metallophosphoesterase
CUC01_00430	COG0492	ferredoxin-NADP+ reductase activity
CUC01_00430	COG3118	belongs to the thioredoxin family
CUC01_00435	COG1760	l-serine dehydratase
CUC01_00450	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CUC01_00470	COG0676	glucose-6-phosphate 1-epimerase activity
CUC01_00480	COG0657	acetylesterase activity
CUC01_00480	COG2755	lipolytic protein G-D-S-L family
CUC01_00495	COG0230	Belongs to the bacterial ribosomal protein bL34 family
CUC01_00505	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
CUC01_00510	COG0706	membrane insertase activity
CUC01_00520	COG0067	glutamate synthase
CUC01_00520	COG0069	glutamate synthase activity
CUC01_00520	COG0070	glutamate synthase
CUC01_00535	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CUC01_00540	COG0505	Belongs to the CarA family
CUC01_00545	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
CUC01_00550	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CUC01_00555	COG1757	Na H antiporter
CUC01_00565	COG1482	cell wall glycoprotein biosynthetic process
CUC01_00575	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
CUC01_00585	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
CUC01_00595	COG0848	biopolymer transport protein
CUC01_00600	COG0811	peptide transport
CUC01_00605	COG0322	excinuclease ABC activity
CUC01_00610	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
CUC01_00615	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
CUC01_00620	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CUC01_00625	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CUC01_00630	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CUC01_00630	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
CUC01_00635	COG2003	Belongs to the UPF0758 family
CUC01_00655	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CUC01_00660	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
CUC01_00680	COG0284	orotidine-5'-phosphate decarboxylase activity
CUC01_00735	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CUC01_00755	COG0437	4 iron, 4 sulfur cluster binding
CUC01_00765	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CUC01_00770	COG3409	Peptidoglycan-binding domain 1 protein
CUC01_00770	COG5632	N-Acetylmuramoyl-L-alanine amidase
CUC01_00775	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
CUC01_00785	COG0736	holo-[acyl-carrier-protein] synthase activity
CUC01_00790	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
CUC01_00795	COG0138	bifunctional purine biosynthesis protein purh
CUC01_00800	COG0359	binds to the 23S rRNA
CUC01_00810	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CUC01_00835	COG1122	ATPase activity
CUC01_00840	COG1199	ATP-dependent helicase activity
CUC01_00850	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
CUC01_00870	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CUC01_00885	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CUC01_00900	COG1477	protein flavinylation
CUC01_00910	COG0148	phosphopyruvate hydratase activity
CUC01_00930	COG2186	Transcriptional regulator
CUC01_00935	COG1119	ATPase activity
CUC01_00940	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
CUC01_00955	COG1090	epimerase
CUC01_00980	COG2311	Membrane
CUC01_00985	COG0714	Associated with various cellular activities
CUC01_01035	COG0789	Transcriptional regulator
CUC01_01040	COG0667	Aldo Keto reductase
CUC01_01055	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CUC01_01075	COG2205	protein histidine kinase activity
CUC01_01080	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
CUC01_01085	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
CUC01_01090	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
CUC01_01125	COG3209	COG3209 Rhs family protein
CUC01_01170	COG1876	peptidase activity
CUC01_01185	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CUC01_01190	COG0534	Mate efflux family protein
CUC01_01215	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CUC01_01220	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CUC01_01255	COG1368	sulfuric ester hydrolase activity
CUC01_01280	COG0129	dihydroxy-acid dehydratase activity
CUC01_01285	COG0745	RESPONSE REGULATOR receiver
CUC01_01310	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
CUC01_01315	COG0006	proline dipeptidase activity
CUC01_01325	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
CUC01_01330	COG1363	Peptidase, m42
CUC01_01360	COG0237	dephospho-CoA kinase activity
CUC01_01365	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
CUC01_01370	COG2217	Heavy metal translocating P-type atpase
CUC01_01375	COG1940	carbohydrate kinase activity
CUC01_01380	COG0590	tRNA wobble adenosine to inosine editing
CUC01_01385	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
CUC01_01390	COG1858	cytochrome C peroxidase
CUC01_01405	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
CUC01_01450	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CUC01_01455	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
CUC01_01475	COG0514	ATP-dependent DNA helicase (RecQ)
CUC01_01480	COG3119	arylsulfatase activity
CUC01_01490	COG1902	pentaerythritol trinitrate reductase activity
CUC01_01490	COG0446	pyridine nucleotide-disulphide oxidoreductase
CUC01_01510	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
CUC01_01515	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CUC01_01520	COG2226	methyltransferase
CUC01_01565	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CUC01_01585	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
CUC01_01600	COG0544	peptidyl-prolyl cis-trans isomerase activity
CUC01_01605	COG0740	serine-type endopeptidase activity
CUC01_01615	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CUC01_01625	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CUC01_01640	COG0250	Participates in transcription elongation, termination and antitermination
CUC01_01645	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
CUC01_01650	COG0081	regulation of translation
CUC01_01655	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
CUC01_01660	COG0222	ribosome binding
CUC01_01665	COG0085	RNA polymerase activity
CUC01_01670	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CUC01_01685	COG0481	GTPase activity
CUC01_01695	COG3119	arylsulfatase activity
CUC01_01705	COG0215	cysteine-tRNA ligase activity
CUC01_01715	COG0697	spore germination
CUC01_01725	COG0488	(ABC) transporter
CUC01_01730	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CUC01_01770	COG2095	MarC family integral membrane protein
CUC01_01775	COG2267	carboxylic ester hydrolase activity
CUC01_01840	COG1073	alpha beta
CUC01_01850	COG1028	Short-chain dehydrogenase reductase Sdr
CUC01_01855	COG1253	flavin adenine dinucleotide binding
CUC01_01870	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
CUC01_01880	COG0488	(ABC) transporter
CUC01_01890	COG1028	Short-chain dehydrogenase reductase Sdr
CUC01_01940	COG1053	succinate dehydrogenase
CUC01_01945	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CUC01_01975	COG1490	D-aminoacyl-tRNA deacylase activity
CUC01_01990	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CUC01_01995	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
CUC01_02000	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CUC01_02005	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CUC01_02025	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CUC01_02030	COG0724	RNA recognition motif
CUC01_02050	COG0842	Transport permease protein
CUC01_02050	COG1131	(ABC) transporter
CUC01_02050	COG1716	ATPase activity
CUC01_02060	COG2006	4fe-4S ferredoxin, iron-sulfur binding domain protein
CUC01_02065	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
CUC01_02070	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CUC01_02075	COG0708	Exodeoxyribonuclease III
CUC01_02080	COG0195	Participates in both transcription termination and antitermination
CUC01_02085	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
CUC01_02090	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
CUC01_02095	COG3119	arylsulfatase activity
CUC01_02105	COG1966	Carbon starvation protein
CUC01_02115	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CUC01_02120	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
CUC01_02125	COG0508	dehydrogenase complex catalyzes the overall conversion of
CUC01_02130	COG0693	protein deglycase activity
CUC01_02135	COG1216	Glycosyl transferase, family 2
CUC01_02150	COG1216	Glycosyl transferase, family 2
CUC01_02160	COG1216	Glycosyl transferase, family 2
CUC01_02170	COG1442	glycosyl transferase family 8
CUC01_02175	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
CUC01_02190	COG0024	Methionine aminopeptidase
CUC01_02195	COG0563	adenylate kinase activity
CUC01_02200	COG0201	protein transport
CUC01_02205	COG0200	Binds to the 23S rRNA
CUC01_02210	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CUC01_02215	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
CUC01_02220	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
CUC01_02225	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
CUC01_02235	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
CUC01_02240	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CUC01_02250	COG0737	Belongs to the 5'-nucleotidase family
CUC01_02255	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CUC01_02260	COG0673	inositol 2-dehydrogenase activity
CUC01_02275	COG0285	dihydrofolate synthase activity
CUC01_02280	COG0826	peptidase U32
CUC01_02290	COG0557	exoribonuclease II activity
CUC01_02300	COG2096	Adenosyltransferase
CUC01_02310	COG2814	Major facilitator Superfamily
CUC01_02320	COG1690	Belongs to the RtcB family
CUC01_02345	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
CUC01_02350	COG5632	N-Acetylmuramoyl-L-alanine amidase
CUC01_02350	COG3409	Peptidoglycan-binding domain 1 protein
CUC01_02410	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CUC01_02415	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CUC01_02420	COG0789	Transcriptional regulator
CUC01_02430	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CUC01_02435	COG0022	dehydrogenase e1 component
CUC01_02440	COG0508	dehydrogenase complex catalyzes the overall conversion of
CUC01_02470	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
CUC01_02475	COG0321	lipoyl(octanoyl) transferase activity
CUC01_02475	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
CUC01_02480	COG0497	DNA recombination
CUC01_02485	COG2217	Heavy metal translocating P-type atpase
CUC01_02495	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CUC01_02505	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CUC01_02510	COG1970	mechanosensitive ion channel activity
CUC01_02515	COG1785	Belongs to the alkaline phosphatase family
CUC01_02520	COG3525	Glycosyl hydrolase, family 20, catalytic domain
CUC01_02525	COG1363	Peptidase, m42
CUC01_02535	COG1592	Rubrerythrin
CUC01_02545	COG2194	sulfuric ester hydrolase activity
CUC01_02575	COG0471	metal ion transport
CUC01_02590	COG0490	domain, Protein
CUC01_02590	COG2985	domain, Protein
CUC01_02620	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CUC01_02625	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CUC01_02635	COG3481	metal-dependent phosphohydrolase, HD sub domain
CUC01_02645	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
CUC01_02650	COG0148	phosphopyruvate hydratase activity
CUC01_02665	COG0165	Argininosuccinate lyase
CUC01_02670	COG0659	secondary active sulfate transmembrane transporter activity
CUC01_02680	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CUC01_02730	COG0542	response to heat
CUC01_02760	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
CUC01_02770	COG0745	RESPONSE REGULATOR receiver
CUC01_02775	COG2205	protein histidine kinase activity
CUC01_02790	COG3250	beta-galactosidase activity
CUC01_02800	COG0084	hydrolase, TatD family'
CUC01_02805	COG0791	NLP P60 protein
CUC01_02805	COG1388	LysM domain
CUC01_02830	COG0592	DNA-directed DNA polymerase activity
CUC01_02840	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CUC01_02845	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CUC01_02845	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CUC01_02850	COG0445	tRNA wobble uridine modification
CUC01_02860	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CUC01_02865	COG0440	acetolactate synthase activity
CUC01_02870	COG1643	Atp-dependent helicase
CUC01_02880	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CUC01_02890	COG0107	imidazoleglycerol-phosphate synthase activity
CUC01_02900	COG1733	regulation of RNA biosynthetic process
CUC01_02920	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CUC01_02930	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
CUC01_02935	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CUC01_02950	COG0535	radical SAM domain protein
CUC01_02985	COG0473	3-isopropylmalate dehydrogenase activity
CUC01_02995	COG3969	phosphoadenosine phosphosulfate
CUC01_03000	COG1475	DNA binding
CUC01_03015	COG1525	nuclease
CUC01_03025	COG1028	Short-chain dehydrogenase reductase Sdr
CUC01_03035	COG1607	acyl-coa hydrolase
CUC01_03040	COG0477	Major facilitator Superfamily
CUC01_03050	COG0588	phosphoglycerate mutase activity
CUC01_03105	COG2755	lipolytic protein G-D-S-L family
CUC01_03105	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
CUC01_03125	COG1216	Glycosyl transferase, family 2
CUC01_03130	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CUC01_03140	COG1216	Glycosyl transferase, family 2
CUC01_03140	COG1442	glycosyl transferase family 8
CUC01_03150	COG1408	metallophosphoesterase
CUC01_03165	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CUC01_03170	COG0196	riboflavin kinase activity
CUC01_03175	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
CUC01_03190	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
CUC01_03210	COG0546	phosphoglycolate phosphatase activity
CUC01_03220	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CUC01_03220	COG0519	Catalyzes the synthesis of GMP from XMP
CUC01_03225	COG0517	IMP dehydrogenase activity
CUC01_03225	COG0516	GMP reductase activity
CUC01_03230	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CUC01_03265	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CUC01_03305	COG0191	fructose-bisphosphate aldolase activity
CUC01_03310	COG0019	diaminopimelate decarboxylase activity
CUC01_03315	COG0628	permease
CUC01_03325	COG0531	amino acid
CUC01_03330	COG2022	thiamine diphosphate biosynthetic process
CUC01_03340	COG4864	UPF0365 protein
CUC01_03345	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
CUC01_03355	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CUC01_03355	COG4651	solute:proton antiporter activity
CUC01_03360	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
CUC01_03365	COG0217	transcriptional regulatory protein
CUC01_03370	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
CUC01_03375	COG0602	queuosine metabolic process
CUC01_03385	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CUC01_03400	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
CUC01_03410	COG2855	membrane
CUC01_03415	COG0583	DNA-binding transcription factor activity
CUC01_03465	COG3118	belongs to the thioredoxin family
CUC01_03475	COG0017	Asparaginyl-tRNA synthetase
CUC01_03500	COG1733	regulation of RNA biosynthetic process
CUC01_03515	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CUC01_03525	COG1137	ATPase activity
CUC01_03540	COG2877	3-deoxy-8-phosphooctulonate synthase activity
CUC01_03555	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CUC01_03565	COG4608	Belongs to the ABC transporter superfamily
CUC01_03575	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CUC01_03585	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CUC01_03595	COG0066	3-isopropylmalate dehydratase activity
CUC01_03600	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CUC01_03605	COG0321	lipoyl(octanoyl) transferase activity
CUC01_03610	COG0860	N-Acetylmuramoyl-L-alanine amidase
CUC01_03615	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CUC01_03625	COG1181	Belongs to the D-alanine--D-alanine ligase family
CUC01_03630	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CUC01_03635	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CUC01_03640	COG0772	Belongs to the SEDS family
CUC01_03655	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CUC01_03660	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CUC01_03665	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CUC01_03670	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CUC01_03675	COG0768	penicillin binding
CUC01_03680	COG0768	penicillin binding
CUC01_03690	COG0275	rRNA processing
CUC01_03695	COG2001	Belongs to the MraZ family
CUC01_03700	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
CUC01_03705	COG2860	membrane
CUC01_03715	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CUC01_03720	COG0482	sulfurtransferase activity
CUC01_03730	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CUC01_03740	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
CUC01_03750	COG0438	transferase activity, transferring glycosyl groups
CUC01_03775	COG1216	Glycosyl transferase, family 2
CUC01_03775	COG0463	Glycosyl transferase, family 2
CUC01_03780	COG1215	transferase activity, transferring glycosyl groups
CUC01_03790	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
CUC01_03795	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CUC01_03800	COG2255	four-way junction helicase activity
CUC01_03850	COG2076	Multidrug Resistance protein
CUC01_03860	COG2226	methyltransferase
CUC01_03870	COG0631	protein serine/threonine phosphatase activity
CUC01_03875	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CUC01_03895	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
CUC01_03915	COG0708	Exodeoxyribonuclease III
CUC01_03950	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
CUC01_03960	COG0571	ribonuclease III activity
CUC01_03970	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CUC01_03980	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
CUC01_04005	COG2815	serine threonine protein kinase
CUC01_04005	COG0515	serine threonine protein kinase
CUC01_04010	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CUC01_04015	COG0424	maF-like protein
CUC01_04020	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CUC01_04040	COG3034	peptidoglycan biosynthetic process
CUC01_04045	COG0673	inositol 2-dehydrogenase activity
CUC01_04075	COG0612	Peptidase, M16
CUC01_04080	COG1663	tetraacyldisaccharide 4'-kinase activity
CUC01_04100	COG3956	TIGRFAM MazG family protein
CUC01_04110	COG1040	competence protein
CUC01_04145	COG0149	triose-phosphate isomerase activity
CUC01_04165	COG0137	argininosuccinate synthase activity
CUC01_04180	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CUC01_04190	COG1253	flavin adenine dinucleotide binding
CUC01_04200	COG0792	nuclease activity
CUC01_04210	COG0134	indole-3-glycerol-phosphate synthase activity
CUC01_04230	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CUC01_04245	COG0848	biopolymer transport protein
CUC01_04270	COG1530	ribonuclease E activity
CUC01_04275	COG1077	Cell shape determining protein MreB Mrl
CUC01_04290	COG1363	Peptidase, m42
CUC01_04300	COG0047	phosphoribosylformylglycinamidine synthase activity
CUC01_04305	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CUC01_04315	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
CUC01_04325	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
CUC01_04335	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
CUC01_04340	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
CUC01_04370	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CUC01_04425	COG0356	it plays a direct role in the translocation of protons across the membrane
CUC01_04435	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CUC01_04440	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CUC01_04445	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CUC01_04450	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CUC01_04455	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CUC01_04460	COG0355	proton-transporting ATP synthase activity, rotational mechanism
CUC01_04480	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CUC01_04525	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CUC01_04545	COG0719	Fe-S assembly protein
CUC01_04550	COG0719	Fe-S assembly protein
CUC01_04555	COG0396	ATPase activity
CUC01_04560	COG0735	belongs to the Fur family
CUC01_04565	COG0211	Belongs to the bacterial ribosomal protein bL27 family
CUC01_04575	COG0802	atpase or kinase
CUC01_04580	COG1073	alpha beta
CUC01_04590	COG5434	Belongs to the glycosyl hydrolase 28 family
CUC01_04605	COG2326	polyphosphate kinase activity
CUC01_04620	COG0742	ribosomal rna small subunit methyltransferase
CUC01_04640	COG1162	GTPase activity
CUC01_04645	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CUC01_04660	COG1349	DNA-binding transcription factor activity
CUC01_04665	COG2326	polyphosphate kinase activity
CUC01_04685	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CUC01_04725	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
CUC01_04730	COG2259	Doxx family
CUC01_04760	COG3119	arylsulfatase activity
CUC01_04775	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CUC01_04775	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CUC01_04790	COG0012	GTP binding
CUC01_04795	COG1686	Belongs to the peptidase S11 family
CUC01_04800	COG0758	DNA mediated transformation
CUC01_04815	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
CUC01_04820	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CUC01_04825	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
CUC01_04830	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CUC01_04855	COG0456	acetyltransferase
CUC01_04865	COG1546	Belongs to the CinA family
CUC01_04865	COG1058	Belongs to the CinA family
CUC01_04885	COG0820	rRNA (adenine-C2-)-methyltransferase activity
CUC01_04890	COG0552	protein localization to endoplasmic reticulum
CUC01_04895	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CUC01_04900	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
CUC01_04905	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CUC01_04905	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CUC01_04910	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CUC01_04925	COG2814	Major facilitator Superfamily
CUC01_04940	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CUC01_04945	COG0828	Belongs to the bacterial ribosomal protein bS21 family
CUC01_04960	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
CUC01_04965	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
CUC01_05000	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CUC01_05010	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
CUC01_05015	COG1136	(ABC) transporter
CUC01_05035	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
CUC01_05040	COG3525	Glycosyl hydrolase, family 20, catalytic domain
CUC01_05055	COG4968	Prepilin-type N-terminal cleavage methylation domain
CUC01_05075	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CUC01_05080	COG0101	tRNA pseudouridine synthase activity
CUC01_05105	COG0110	maltose O-acetyltransferase activity
CUC01_05110	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
CUC01_05115	COG1185	polyribonucleotide nucleotidyltransferase activity
CUC01_05125	COG1253	flavin adenine dinucleotide binding
CUC01_05130	COG1253	flavin adenine dinucleotide binding
CUC01_05150	COG0352	thiamine-phosphate diphosphorylase activity
CUC01_05155	COG0167	dihydroorotate dehydrogenase activity
CUC01_05170	COG0076	glutamate decarboxylase activity
CUC01_05185	COG3525	Glycosyl hydrolase, family 20, catalytic domain
CUC01_05195	COG0038	chloride channel
CUC01_05215	COG0300	oxidoreductase activity
CUC01_05225	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
CUC01_05245	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
CUC01_05305	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CUC01_05310	COG0799	negative regulation of ribosome biogenesis
CUC01_05320	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CUC01_05365	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CUC01_05375	COG0577	efflux transmembrane transporter activity
CUC01_05375	COG1136	(ABC) transporter
CUC01_05445	COG0444	Belongs to the ABC transporter superfamily
CUC01_05450	COG1160	GTP binding
CUC01_05455	COG0795	lipopolysaccharide-transporting ATPase activity
CUC01_05470	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CUC01_05475	COG1722	exodeoxyribonuclease VII activity
CUC01_05485	COG2204	response regulator
CUC01_05490	COG3852	Histidine kinase
CUC01_05500	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
CUC01_05505	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CUC01_05510	COG0049	tRNA binding
CUC01_05515	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CUC01_05520	COG0051	transcription antitermination factor activity, RNA binding
CUC01_05525	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CUC01_05530	COG0088	Forms part of the polypeptide exit tunnel
CUC01_05535	COG0089	rRNA binding
CUC01_05540	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CUC01_05545	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CUC01_05555	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
CUC01_05560	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CUC01_05565	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CUC01_05570	COG0255	Belongs to the universal ribosomal protein uL29 family
CUC01_05575	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CUC01_05580	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
CUC01_05595	COG0525	valine-tRNA ligase activity
CUC01_05600	COG3250	beta-galactosidase activity
CUC01_05620	COG0811	peptide transport
CUC01_05655	COG0776	regulation of translation
CUC01_05660	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CUC01_05665	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
CUC01_05675	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CUC01_05680	COG0343	queuine tRNA-ribosyltransferase activity
CUC01_05685	COG1862	Preprotein translocase
CUC01_05710	COG0228	four-way junction DNA binding
CUC01_05715	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CUC01_05720	COG0009	L-threonylcarbamoyladenylate synthase
CUC01_05725	COG0537	adenosine 5'-monophosphoramidase activity
CUC01_05735	COG0333	Belongs to the bacterial ribosomal protein bL32 family
CUC01_05740	COG0416	fatty acid biosynthetic process
CUC01_05750	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
CUC01_05750	COG0662	Cupin 2, conserved barrel domain protein
CUC01_05775	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CUC01_05815	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CUC01_05820	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
CUC01_05825	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
CUC01_05830	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
CUC01_05880	COG0539	negative regulation of cytoplasmic translation
CUC01_05890	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
CUC01_05895	COG0336	Belongs to the RNA methyltransferase TrmD family
CUC01_05905	COG1187	pseudouridine synthase activity
CUC01_05925	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
CUC01_05930	COG1393	Belongs to the ArsC family
CUC01_05935	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CUC01_05950	COG1063	alcohol dehydrogenase
CUC01_05955	COG0242	peptide deformylase activity
CUC01_05965	COG1028	Short-chain dehydrogenase reductase Sdr
CUC01_06025	COG0351	phosphomethylpyrimidine kinase
CUC01_06035	COG0471	metal ion transport
CUC01_06050	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CUC01_06070	COG0028	Belongs to the TPP enzyme family
CUC01_06075	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CUC01_06085	COG0205	6-phosphofructokinase activity
CUC01_06095	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
CUC01_06105	COG0427	acetyl-CoA hydrolase
CUC01_06110	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
CUC01_06110	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
CUC01_06115	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
CUC01_06120	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
CUC01_06135	COG0346	lactoylglutathione lyase activity
CUC01_06145	COG0335	large ribosomal subunit rRNA binding
CUC01_06160	COG2267	carboxylic ester hydrolase activity
CUC01_06165	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CUC01_06190	COG2755	lipolytic protein G-D-S-L family
CUC01_06190	COG0657	acetylesterase activity
CUC01_06195	COG2234	aminopeptidase activity
CUC01_06220	COG4591	ABC-type transport system involved in lipoprotein release permease component
CUC01_06230	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CUC01_06235	COG0546	phosphoglycolate phosphatase activity
CUC01_06240	COG1322	Protein conserved in bacteria
CUC01_06250	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CUC01_06275	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CUC01_06280	COG0504	CTP synthase activity
CUC01_06285	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
CUC01_06300	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CUC01_06330	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
CUC01_06335	COG1127	ABC transporter
CUC01_06350	COG1132	(ABC) transporter
CUC01_06355	COG1132	(ABC) transporter
CUC01_06360	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CUC01_06420	COG0601	transmembrane transport
CUC01_06425	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CUC01_06440	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CUC01_06475	COG1475	DNA binding
CUC01_06540	COG1918	ferrous iron import across plasma membrane
CUC01_06540	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
CUC01_06550	COG3119	arylsulfatase activity
CUC01_06560	COG0750	zinc metalloprotease
CUC01_06570	COG2957	Belongs to the agmatine deiminase family
CUC01_06575	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
CUC01_06595	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
CUC01_06600	COG0540	Belongs to the ATCase OTCase family
CUC01_06605	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CUC01_06610	COG1720	tRNA m6t6A37 methyltransferase activity
CUC01_06620	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CUC01_06635	COG1538	Outer membrane efflux protein
CUC01_06640	COG0577	efflux transmembrane transporter activity
CUC01_06640	COG1136	(ABC) transporter
CUC01_06645	COG1136	(ABC) transporter
CUC01_06645	COG0577	efflux transmembrane transporter activity
CUC01_06650	COG1566	PFAM secretion protein HlyD family protein
CUC01_06655	COG0494	nUDIX hydrolase
CUC01_06670	COG1940	carbohydrate kinase activity
CUC01_06675	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
CUC01_06680	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CUC01_06685	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CUC01_06690	COG1469	GTP cyclohydrolase I activity
CUC01_06700	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
CUC01_06705	COG0181	hydroxymethylbilane synthase activity
CUC01_06715	COG3189	MarR family transcriptional regulator
CUC01_06730	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
CUC01_06770	COG0515	serine threonine protein kinase
CUC01_06770	COG3266	domain, Protein
CUC01_06775	COG1192	Involved in chromosome partitioning
CUC01_06785	COG0156	8-amino-7-oxononanoate synthase activity
CUC01_06800	COG2816	NAD+ diphosphatase activity
CUC01_06805	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CUC01_06820	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
CUC01_06830	COG1692	metallophosphoesterase
CUC01_06840	COG0180	Tryptophanyl-tRNA synthetase
CUC01_06850	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
CUC01_06850	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
CUC01_06865	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CUC01_06870	COG0179	Fumarylacetoacetate (FAA) hydrolase
CUC01_06905	COG0542	response to heat
CUC01_06910	COG3869	Catalyzes the specific phosphorylation of arginine residues in
CUC01_06915	COG3880	PFAM UvrB UvrC protein
CUC01_06920	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CUC01_06925	COG1121	(ABC) transporter
CUC01_06945	COG3525	Glycosyl hydrolase, family 20, catalytic domain
CUC01_06950	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CUC01_06955	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CUC01_06960	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CUC01_06965	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CUC01_06980	COG0534	Mate efflux family protein
CUC01_06985	COG2226	methyltransferase
CUC01_07005	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
CUC01_07010	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CUC01_07015	COG2890	protein-(glutamine-N5) methyltransferase activity
CUC01_07020	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CUC01_07030	COG1115	amino acid carrier protein
CUC01_07045	COG2066	Belongs to the glutaminase family
CUC01_07050	COG0531	amino acid
CUC01_07075	COG0442	prolyl-tRNA aminoacylation
CUC01_07100	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CUC01_07130	COG1971	Probably functions as a manganese efflux pump
CUC01_07145	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
CUC01_07150	COG2814	Major facilitator Superfamily
CUC01_07165	COG0673	inositol 2-dehydrogenase activity
CUC01_07180	COG0513	Belongs to the DEAD box helicase family
CUC01_07190	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CUC01_07195	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CUC01_07210	COG0564	pseudouridine synthase activity
CUC01_07215	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
CUC01_07235	COG1131	(ABC) transporter
CUC01_07240	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CUC01_07245	COG0494	nUDIX hydrolase
CUC01_07265	COG0653	protein targeting
CUC01_07270	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CUC01_07310	COG0018	arginyl-trna synthetase
CUC01_07320	COG0339	signal peptide processing
CUC01_07350	COG0318	PFAM AMP-dependent synthetase and ligase
CUC01_07365	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CUC01_07370	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CUC01_07410	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CUC01_07415	COG3525	Glycosyl hydrolase, family 20, catalytic domain
CUC01_07435	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
CUC01_07435	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
CUC01_07445	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CUC01_07445	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CUC01_07465	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CUC01_07470	COG0778	Nitroreductase
CUC01_07495	COG0375	protein maturation
CUC01_07510	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
CUC01_07535	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CUC01_07550	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CUC01_07555	COG0193	aminoacyl-tRNA hydrolase activity
CUC01_07565	COG0714	Associated with various cellular activities
CUC01_07580	COG1063	alcohol dehydrogenase
CUC01_07585	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CUC01_07595	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CUC01_07615	COG1472	Belongs to the glycosyl hydrolase 3 family
CUC01_07630	COG0280	phosphate acetyltransferase
CUC01_07630	COG0281	malic enzyme
CUC01_07645	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
CUC01_07650	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CUC01_07650	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CUC01_07655	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
CUC01_07675	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
CUC01_07675	COG2755	lipolytic protein G-D-S-L family
CUC01_07695	COG1216	Glycosyl transferase, family 2
CUC01_07705	COG0110	maltose O-acetyltransferase activity
CUC01_07745	COG0438	transferase activity, transferring glycosyl groups
CUC01_07755	COG0438	transferase activity, transferring glycosyl groups
CUC01_07765	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CUC01_07775	COG0489	protein tyrosine kinase activity
CUC01_07790	COG1674	ftsk spoiiie
CUC01_07800	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CUC01_07810	COG1592	Rubrerythrin
CUC01_07815	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CUC01_07830	COG0753	catalase activity
CUC01_07850	COG1012	belongs to the aldehyde dehydrogenase family
CUC01_07925	COG0586	Pfam SNARE associated Golgi protein
CUC01_07930	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CUC01_07935	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CUC01_07955	COG0038	chloride channel
CUC01_07970	COG4112	unkown
CUC01_07985	COG1538	Outer membrane efflux protein
CUC01_07995	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CUC01_08000	COG0339	signal peptide processing
CUC01_08005	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CUC01_08020	COG0489	protein tyrosine kinase activity
CUC01_08025	COG0534	Mate efflux family protein
CUC01_08040	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CUC01_08060	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CUC01_08075	COG0418	dihydroorotase activity
CUC01_08080	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CUC01_08090	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
CUC01_08110	COG1703	isobutyryl-CoA mutase activity
CUC01_08135	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
CUC01_08140	COG0352	thiamine-phosphate diphosphorylase activity
CUC01_08155	COG1959	2 iron, 2 sulfur cluster binding
CUC01_08160	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CUC01_08175	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
CUC01_08195	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CUC01_08200	COG0326	Molecular chaperone. Has ATPase activity
CUC01_08220	COG0072	phenylalanine-tRNA ligase activity
CUC01_08220	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CUC01_08235	COG3033	Beta-eliminating lyase
CUC01_08255	COG2818	Glycosylase
CUC01_08265	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CUC01_08295	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CUC01_08295	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CUC01_08315	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
CUC01_08325	COG0166	Belongs to the GPI family
CUC01_08335	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CUC01_08335	COG0574	Belongs to the PEP-utilizing enzyme family
CUC01_08340	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
CUC01_08345	COG1194	a g-specific adenine glycosylase
CUC01_08350	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CUC01_08360	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CUC01_08375	COG5522	Integral membrane protein (intg_mem_TP0381)
CUC01_08385	COG0527	aspartate kinase activity
CUC01_08390	COG0460	homoserine dehydrogenase
CUC01_08400	COG3610	response to peptide
CUC01_08405	COG2966	Psort location CytoplasmicMembrane, score
CUC01_08410	COG1410	methionine synthase
CUC01_08410	COG0646	methionine synthase
CUC01_08440	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CUC01_08445	COG0519	Catalyzes the synthesis of GMP from XMP
CUC01_08445	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CUC01_08470	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CUC01_08505	COG2195	Cleaves the N-terminal amino acid of tripeptides
CUC01_08510	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CUC01_08530	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CUC01_08530	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CUC01_08565	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CUC01_08570	COG4605	iron ion homeostasis
CUC01_08575	COG4604	ABC transporter, ATP-binding protein
CUC01_08580	COG4607	ABC-type enterochelin transport system periplasmic component
CUC01_08590	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CUC01_08630	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
CUC01_08635	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CUC01_08635	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
CUC01_08650	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CUC01_08665	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
CUC01_08675	COG1454	alcohol dehydrogenase
CUC01_08700	COG4974	Belongs to the 'phage' integrase family
CUC01_08725	COG1408	metallophosphoesterase
CUC01_08735	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
CUC01_08745	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
CUC01_08755	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CUC01_08765	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CUC01_08785	COG1968	undecaprenyl-diphosphatase activity
CUC01_08790	COG0805	protein transport
CUC01_08795	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CUC01_08795	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
CUC01_08800	COG0668	transmembrane transport
CUC01_08810	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
CUC01_08815	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CUC01_08820	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
CUC01_08840	COG0538	isocitrate dehydrogenase activity
CUC01_08845	COG3274	enterobacterial common antigen metabolic process
CUC01_08855	COG3258	Cytochrome c
CUC01_08865	COG2010	Cytochrome c
CUC01_08900	COG0242	peptide deformylase activity
CUC01_08910	COG0811	peptide transport
CUC01_08925	COG0151	Belongs to the GarS family
CUC01_08930	COG3738	Protein conserved in bacteria
CUC01_08935	COG2759	Belongs to the formate--tetrahydrofolate ligase family
CUC01_08940	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
CUC01_08960	COG0601	transmembrane transport
CUC01_08965	COG4239	(ABC) transporter, permease
CUC01_08970	COG4166	transmembrane transport
CUC01_08975	COG0444	Belongs to the ABC transporter superfamily
CUC01_08980	COG4608	Belongs to the ABC transporter superfamily
CUC01_08985	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CUC01_09010	COG0232	Belongs to the dGTPase family. Type 2 subfamily
CUC01_09030	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CUC01_09050	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
CUC01_09075	COG1595	DNA-templated transcription, initiation
CUC01_09090	COG0738	Major facilitator superfamily
CUC01_09105	COG1070	Carbohydrate kinase
CUC01_09125	COG1741	Belongs to the pirin family
CUC01_09135	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
CUC01_09155	COG0363	glucosamine-6-phosphate deaminase activity
CUC01_09160	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
CUC01_09170	COG1837	Belongs to the UPF0109 family
CUC01_09185	COG1091	dTDP-4-dehydrorhamnose reductase activity
CUC01_09210	COG0534	Mate efflux family protein
CUC01_09225	COG0789	Transcriptional regulator
CUC01_09230	COG2249	NAD(P)H dehydrogenase (quinone) activity
CUC01_09240	COG0667	Aldo Keto reductase
CUC01_09260	COG1408	metallophosphoesterase
CUC01_09265	COG0667	Aldo Keto reductase
CUC01_09275	COG0656	L-ascorbic acid biosynthetic process
CUC01_09285	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
CUC01_09315	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
CUC01_09315	COG2755	lipolytic protein G-D-S-L family
CUC01_09325	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CUC01_09330	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CUC01_09370	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CUC01_09375	COG0154	amidase activity
CUC01_09380	COG0714	Associated with various cellular activities
CUC01_09410	COG0656	L-ascorbic acid biosynthetic process
CUC01_09415	COG0423	glycine-tRNA ligase activity
CUC01_09430	COG0436	Aminotransferase
CUC01_09435	COG1522	sequence-specific DNA binding
CUC01_09445	COG2967	ApaG domain
CUC01_09455	COG1215	transferase activity, transferring glycosyl groups
CUC01_09470	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CUC01_09485	COG1131	(ABC) transporter
CUC01_09490	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CUC01_09495	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
CUC01_09500	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CUC01_09505	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CUC01_09515	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CUC01_09520	COG2166	iron-sulfur cluster assembly
CUC01_09530	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
CUC01_09535	COG3475	LICD family
CUC01_09545	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CUC01_09555	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
CUC01_09565	COG3475	LICD family
CUC01_09610	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
CUC01_09630	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CUC01_09645	COG0113	porphobilinogen synthase activity
CUC01_09660	COG2205	protein histidine kinase activity
CUC01_09665	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CUC01_09740	COG0045	succinate-CoA ligase (ADP-forming) activity
CUC01_09745	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
CUC01_09760	COG0514	ATP-dependent DNA helicase (RecQ)
CUC01_09795	COG2949	membrane
CUC01_09820	COG1846	Transcriptional regulator
CUC01_09840	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CUC01_09850	COG1271	oxidase subunit
CUC01_09855	COG1294	oxidase, subunit
CUC01_09880	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CUC01_09885	COG0402	S-adenosylhomocysteine deaminase activity
CUC01_09905	COG4771	TonB-dependent receptor
CUC01_09920	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
CUC01_09925	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
CUC01_09930	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
CUC01_09975	COG0205	6-phosphofructokinase activity
CUC01_09995	COG3525	Glycosyl hydrolase, family 20, catalytic domain
CUC01_10000	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CUC01_10005	COG3250	beta-galactosidase activity
CUC01_10010	COG3250	beta-galactosidase activity
CUC01_10050	COG1166	arginine decarboxylase activity
CUC01_10065	COG3119	arylsulfatase activity
CUC01_10070	COG0495	leucyl-tRNA aminoacylation
CUC01_10075	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CUC01_10080	COG0688	phosphatidylethanolamine metabolic process
CUC01_10090	COG0028	Belongs to the TPP enzyme family
CUC01_10095	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CUC01_10100	COG0268	Binds directly to 16S ribosomal RNA
CUC01_10110	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
CUC01_10115	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CUC01_10135	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CUC01_10150	COG1450	Type ii and iii secretion system protein
CUC01_10175	COG1643	Atp-dependent helicase
CUC01_10190	COG0793	Belongs to the peptidase S41A family
CUC01_10195	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CUC01_10210	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
CUC01_10215	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CUC01_10220	COG0358	DNA primase activity
CUC01_10225	COG1030	water channel activity
CUC01_10230	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CUC01_10245	COG1640	4-alpha-glucanotransferase
CUC01_10250	COG3210	domain, Protein
CUC01_10265	COG2264	protein methyltransferase activity
CUC01_10275	COG0307	riboflavin synthase, alpha
CUC01_10285	COG0726	polysaccharide deacetylase
CUC01_10295	COG0649	NAD binding
CUC01_10300	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
CUC01_10305	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
CUC01_10310	COG1034	ATP synthesis coupled electron transport
CUC01_10315	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
CUC01_10325	COG0839	Belongs to the complex I subunit 6 family
CUC01_10330	COG0713	ATP synthesis coupled electron transport
CUC01_10340	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CUC01_10345	COG1007	ATP synthesis coupled electron transport
CUC01_10360	COG2151	metal-sulfur cluster biosynthetic enzyme
CUC01_10375	COG0142	geranyltranstransferase activity
CUC01_10380	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
CUC01_10385	COG0037	tRNA processing
CUC01_10390	COG1691	(AIR) carboxylase
CUC01_10395	COG1649	PFAM Uncharacterised BCR, COG1649
CUC01_10405	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
CUC01_10405	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
CUC01_10410	COG0728	peptidoglycan biosynthetic process
CUC01_10425	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CUC01_10435	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CUC01_10440	COG1459	type II secretion system
CUC01_10450	COG0463	Glycosyl transferase, family 2
CUC01_10455	COG1215	transferase activity, transferring glycosyl groups
CUC01_10460	COG0105	UTP biosynthetic process
CUC01_10470	COG1187	pseudouridine synthase activity
CUC01_10480	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
CUC01_10495	COG0372	Belongs to the citrate synthase family
CUC01_10520	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CUC01_10530	COG1979	alcohol dehydrogenase
CUC01_10535	COG2373	Large extracellular alpha-helical protein
CUC01_10545	COG0697	spore germination
CUC01_10560	COG1074	ATP-dependent DNA helicase activity
CUC01_10575	COG0750	zinc metalloprotease
CUC01_10580	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
CUC01_10585	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CUC01_10590	COG0556	nucleotide-excision repair
CUC01_10610	COG2223	nitrite transmembrane transporter activity
CUC01_10615	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CUC01_10625	COG0561	phosphatase activity
CUC01_10655	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
CUC01_10670	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CUC01_10675	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CUC01_10695	COG0159	tryptophan synthase activity
CUC01_10705	COG0135	phosphoribosylanthranilate isomerase activity
CUC01_10710	COG0134	indole-3-glycerol-phosphate synthase activity
CUC01_10715	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CUC01_10720	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CUC01_10740	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
CUC01_10745	COG0667	Aldo Keto reductase
CUC01_10785	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CUC01_10820	COG2885	chlorophyll binding
CUC01_10835	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CUC01_10845	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
CUC01_10850	COG0203	ribosomal protein L17
CUC01_10855	COG0202	RNA polymerase activity
CUC01_10875	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CUC01_10875	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CUC01_10880	COG0726	polysaccharide deacetylase
CUC01_10915	COG1575	Belongs to the MenA family. Type 1 subfamily
CUC01_10930	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CUC01_10935	COG3273	potassium ion transport
CUC01_10935	COG0471	metal ion transport
CUC01_10945	COG1561	YicC-like family, N-terminal region
CUC01_10950	COG3977	Valine--pyruvate aminotransferase
CUC01_10965	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CUC01_10970	COG0428	transporter
CUC01_10980	COG0205	6-phosphofructokinase activity
CUC01_10985	COG1686	Belongs to the peptidase S11 family
CUC01_11000	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
CUC01_11005	COG0360	Binds together with S18 to 16S ribosomal RNA
CUC01_11015	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
CUC01_11020	COG0131	Imidazoleglycerol-phosphate dehydratase
CUC01_11035	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
CUC01_11040	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CUC01_11070	COG0277	FAD linked oxidase domain protein
CUC01_11085	COG5434	Belongs to the glycosyl hydrolase 28 family
CUC01_11095	COG1385	rRNA (uridine-N3-)-methyltransferase activity
CUC01_11105	COG0484	heat shock protein binding
CUC01_11115	COG1872	DUF167
CUC01_11120	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
CUC01_11145	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CUC01_11165	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
CUC01_11170	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
CUC01_11180	COG0765	amino acid transport
CUC01_11185	COG1126	abc transporter atp-binding protein
CUC01_11210	COG0564	pseudouridine synthase activity
CUC01_11215	COG0778	Nitroreductase
CUC01_11240	COG0039	L-malate dehydrogenase activity
CUC01_11245	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
CUC01_11280	COG0254	rRNA binding
CUC01_11285	COG0037	tRNA processing
CUC01_11295	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
CUC01_11310	COG2271	Major facilitator Superfamily
CUC01_11320	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CUC01_11330	COG1082	Xylose isomerase domain protein TIM barrel
CUC01_11345	COG0126	phosphoglycerate kinase activity
CUC01_11355	COG0632	four-way junction helicase activity
CUC01_11405	COG0459	protein refolding
CUC01_11410	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CUC01_11415	COG0443	Heat shock 70 kDa protein
CUC01_11420	COG0438	transferase activity, transferring glycosyl groups
CUC01_11450	COG0298	carbon dioxide binding
CUC01_11455	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
CUC01_11460	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
CUC01_11465	COG0124	histidyl-tRNA synthetase
CUC01_11470	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CUC01_11500	COG0156	8-amino-7-oxononanoate synthase activity
CUC01_11525	COG1028	Short-chain dehydrogenase reductase Sdr
CUC01_11530	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
CUC01_11540	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CUC01_11550	COG1183	phosphatidylcholine synthase activity
CUC01_11555	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CUC01_11565	COG1131	(ABC) transporter
CUC01_11570	COG0842	Transport permease protein
CUC01_11575	COG0842	Transport permease protein
CUC01_11590	COG0305	Participates in initiation and elongation during chromosome replication