locus-tag	class	description
J5W49_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
J5W49_00010	COG1131	(ABC) transporter
J5W49_00030	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
J5W49_00035	COG0564	pseudouridine synthase activity
J5W49_00040	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
J5W49_00045	COG0077	Prephenate dehydratase
J5W49_00045	COG1605	Chorismate mutase
J5W49_00055	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
J5W49_00060	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
J5W49_00065	COG0513	Belongs to the DEAD box helicase family
J5W49_00075	COG0673	inositol 2-dehydrogenase activity
J5W49_00100	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
J5W49_00110	COG1971	Probably functions as a manganese efflux pump
J5W49_00130	COG2755	lipolytic protein G-D-S-L family
J5W49_00130	COG0657	acetylesterase activity
J5W49_00170	COG0442	prolyl-tRNA aminoacylation
J5W49_00220	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
J5W49_00225	COG0402	S-adenosylhomocysteine deaminase activity
J5W49_00250	COG4771	TonB-dependent receptor
J5W49_00285	COG3896	Chloramphenicol phosphotransferase-like protein
J5W49_00300	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
J5W49_00305	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
J5W49_00345	COG0205	6-phosphofructokinase activity
J5W49_00360	COG1228	amidohydrolase
J5W49_00370	COG1335	isochorismatase
J5W49_00375	COG3525	Glycosyl hydrolase, family 20, catalytic domain
J5W49_00380	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
J5W49_00390	COG3250	beta-galactosidase activity
J5W49_00395	COG3250	beta-galactosidase activity
J5W49_00400	COG3250	beta-galactosidase activity
J5W49_00410	COG1166	arginine decarboxylase activity
J5W49_00430	COG0495	leucyl-tRNA aminoacylation
J5W49_00435	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
J5W49_00455	COG0028	Belongs to the TPP enzyme family
J5W49_00460	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
J5W49_00465	COG0268	Binds directly to 16S ribosomal RNA
J5W49_00475	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
J5W49_00480	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
J5W49_00505	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
J5W49_00520	COG1450	Type ii and iii secretion system protein
J5W49_00530	COG0617	tRNA 3'-terminal CCA addition
J5W49_00550	COG1643	Atp-dependent helicase
J5W49_00555	COG0575	Belongs to the CDS family
J5W49_00560	COG0793	Belongs to the peptidase S41A family
J5W49_00565	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
J5W49_00580	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
J5W49_00585	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
J5W49_00590	COG0358	DNA primase activity
J5W49_00595	COG1030	water channel activity
J5W49_00600	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
J5W49_00610	COG1640	4-alpha-glucanotransferase
J5W49_00630	COG0307	riboflavin synthase, alpha
J5W49_00640	COG0726	polysaccharide deacetylase
J5W49_00645	COG0649	NAD binding
J5W49_00650	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
J5W49_00655	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
J5W49_00660	COG1034	ATP synthesis coupled electron transport
J5W49_00665	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
J5W49_00675	COG0839	Belongs to the complex I subunit 6 family
J5W49_00680	COG0713	ATP synthesis coupled electron transport
J5W49_00690	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
J5W49_00695	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
J5W49_00700	COG1007	ATP synthesis coupled electron transport
J5W49_00720	COG2151	metal-sulfur cluster biosynthetic enzyme
J5W49_00735	COG0142	geranyltranstransferase activity
J5W49_00740	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
J5W49_00745	COG1606	tRNA processing
J5W49_00750	COG1691	(AIR) carboxylase
J5W49_00755	COG1649	PFAM Uncharacterised BCR, COG1649
J5W49_00765	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
J5W49_00765	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
J5W49_00770	COG0728	peptidoglycan biosynthetic process
J5W49_00800	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
J5W49_00810	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
J5W49_00815	COG1459	type II secretion system
J5W49_00825	COG0463	Glycosyl transferase, family 2
J5W49_00830	COG1215	transferase activity, transferring glycosyl groups
J5W49_00835	COG0105	UTP biosynthetic process
J5W49_00845	COG1187	pseudouridine synthase activity
J5W49_00855	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
J5W49_00875	COG3647	Membrane
J5W49_00880	COG0372	Belongs to the citrate synthase family
J5W49_00885	COG1214	PFAM Peptidase M22, glycoprotease
J5W49_00935	COG1979	alcohol dehydrogenase
J5W49_00940	COG2373	Large extracellular alpha-helical protein
J5W49_00945	COG0697	spore germination
J5W49_00960	COG1074	ATP-dependent DNA helicase activity
J5W49_01010	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
J5W49_01015	COG0291	Belongs to the bacterial ribosomal protein bL35 family
J5W49_01025	COG0556	nucleotide-excision repair
J5W49_01060	COG0738	Major facilitator superfamily
J5W49_01065	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
J5W49_01075	COG0561	phosphatase activity
J5W49_01120	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
J5W49_01140	COG0257	Belongs to the bacterial ribosomal protein bL36 family
J5W49_01145	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
J5W49_01160	COG0159	tryptophan synthase activity
J5W49_01170	COG0135	phosphoribosylanthranilate isomerase activity
J5W49_01175	COG0134	indole-3-glycerol-phosphate synthase activity
J5W49_01180	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
J5W49_01185	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
J5W49_01195	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
J5W49_01200	COG0667	Aldo Keto reductase
J5W49_01230	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
J5W49_01275	COG2885	chlorophyll binding
J5W49_01290	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
J5W49_01305	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
J5W49_01325	COG0203	ribosomal protein L17
J5W49_01330	COG0202	RNA polymerase activity
J5W49_01350	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
J5W49_01350	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
J5W49_01355	COG0726	polysaccharide deacetylase
J5W49_01380	COG0710	3-dehydroquinate dehydratase activity
J5W49_01400	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
J5W49_01405	COG3273	potassium ion transport
J5W49_01405	COG0471	metal ion transport
J5W49_01415	COG1561	YicC-like family, N-terminal region
J5W49_01420	COG3977	Valine--pyruvate aminotransferase
J5W49_01435	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
J5W49_01440	COG0428	transporter
J5W49_01445	COG3152	Membrane
J5W49_01450	COG0205	6-phosphofructokinase activity
J5W49_01455	COG1686	Belongs to the peptidase S11 family
J5W49_01470	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
J5W49_01485	COG0360	Binds together with S18 to 16S ribosomal RNA
J5W49_01495	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
J5W49_01500	COG0131	Imidazoleglycerol-phosphate dehydratase
J5W49_01510	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
J5W49_01515	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
J5W49_01540	COG0277	FAD linked oxidase domain protein
J5W49_01560	COG1385	rRNA (uridine-N3-)-methyltransferase activity
J5W49_01565	COG0484	heat shock protein binding
J5W49_01570	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
J5W49_01575	COG1872	DUF167
J5W49_01580	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
J5W49_01615	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
J5W49_01635	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
J5W49_01640	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
J5W49_01665	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
J5W49_01670	COG0765	amino acid transport
J5W49_01750	COG0564	pseudouridine synthase activity
J5W49_01755	COG0778	Nitroreductase
J5W49_01775	COG0039	L-malate dehydrogenase activity
J5W49_01780	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
J5W49_01805	COG0254	rRNA binding
J5W49_01810	COG0037	tRNA processing
J5W49_01820	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
J5W49_01845	COG2271	Major facilitator Superfamily
J5W49_01855	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
J5W49_01865	COG0126	phosphoglycerate kinase activity
J5W49_01920	COG0459	protein refolding
J5W49_01925	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
J5W49_01930	COG0443	Heat shock 70 kDa protein
J5W49_01935	COG0438	transferase activity, transferring glycosyl groups
J5W49_01955	COG0298	carbon dioxide binding
J5W49_01960	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
J5W49_01965	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
J5W49_01975	COG0124	histidyl-tRNA synthetase
J5W49_01980	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
J5W49_02010	COG3209	COG3209 Rhs family protein
J5W49_02050	COG0156	8-amino-7-oxononanoate synthase activity
J5W49_02065	COG1028	Short-chain dehydrogenase reductase Sdr
J5W49_02070	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
J5W49_02090	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
J5W49_02100	COG1183	phosphatidylcholine synthase activity
J5W49_02105	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
J5W49_02115	COG1131	(ABC) transporter
J5W49_02120	COG0842	Transport permease protein
J5W49_02125	COG0842	Transport permease protein
J5W49_02135	COG3468	outer membrane autotransporter barrel domain protein
J5W49_02145	COG0456	acetyltransferase
J5W49_02160	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
J5W49_02165	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
J5W49_02175	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
J5W49_02185	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
J5W49_02190	COG4335	DNA alkylation repair
J5W49_02215	COG0733	neurotransmitter:sodium symporter activity
J5W49_02220	COG0450	alkyl hydroperoxide reductase
J5W49_02230	COG0668	transmembrane transport
J5W49_02235	COG0528	UMP kinase activity
J5W49_02240	COG0233	cytoplasmic translational termination
J5W49_02250	COG0612	Peptidase, M16
J5W49_02285	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
J5W49_02300	COG0573	inorganic phosphate transmembrane transporter activity
J5W49_02305	COG0581	inorganic phosphate transmembrane transporter activity
J5W49_02310	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
J5W49_02380	COG1262	PFAM Formylglycine-generating sulfatase enzyme
J5W49_02395	COG0826	peptidase U32
J5W49_02410	COG0187	DNA topoisomerase II activity
J5W49_02420	COG0545	Peptidyl-prolyl cis-trans isomerase
J5W49_02425	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
J5W49_02435	COG1408	metallophosphoesterase
J5W49_02470	COG0492	ferredoxin-NADP+ reductase activity
J5W49_02470	COG3118	belongs to the thioredoxin family
J5W49_02475	COG1760	l-serine dehydratase
J5W49_02485	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
J5W49_02500	COG0259	pyridoxamine-phosphate oxidase activity
J5W49_02505	COG0676	glucose-6-phosphate 1-epimerase activity
J5W49_02520	COG0230	Belongs to the bacterial ribosomal protein bL34 family
J5W49_02525	COG0594	ribonuclease P activity
J5W49_02530	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
J5W49_02535	COG0706	membrane insertase activity
J5W49_02540	COG1234	tRNA 3'-trailer cleavage
J5W49_02545	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
J5W49_02555	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
J5W49_02565	COG0848	biopolymer transport protein
J5W49_02570	COG0811	peptide transport
J5W49_02575	COG0322	excinuclease ABC activity
J5W49_02580	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
J5W49_02590	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
J5W49_02595	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
J5W49_02600	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
J5W49_02605	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
J5W49_02605	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
J5W49_02610	COG2003	Belongs to the UPF0758 family
J5W49_02630	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
J5W49_02655	COG0284	orotidine-5'-phosphate decarboxylase activity
J5W49_02715	COG0662	Cupin 2, conserved barrel domain protein
J5W49_02715	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
J5W49_02725	COG0416	fatty acid biosynthetic process
J5W49_02730	COG0333	Belongs to the bacterial ribosomal protein bL32 family
J5W49_02740	COG0537	adenosine 5'-monophosphoramidase activity
J5W49_02745	COG0009	L-threonylcarbamoyladenylate synthase
J5W49_02750	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
J5W49_02755	COG0228	four-way junction DNA binding
J5W49_02775	COG1862	Preprotein translocase
J5W49_02780	COG0343	queuine tRNA-ribosyltransferase activity
J5W49_02785	COG0220	tRNA (guanine-N7-)-methyltransferase activity
J5W49_02795	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
J5W49_02800	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
J5W49_02805	COG0776	regulation of translation
J5W49_02840	COG0811	peptide transport
J5W49_02855	COG3250	beta-galactosidase activity
J5W49_02860	COG0525	valine-tRNA ligase activity
J5W49_02870	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
J5W49_02875	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
J5W49_02880	COG0255	Belongs to the universal ribosomal protein uL29 family
J5W49_02885	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
J5W49_02890	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
J5W49_02895	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
J5W49_02905	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
J5W49_02910	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
J5W49_02915	COG0089	rRNA binding
J5W49_02920	COG0088	Forms part of the polypeptide exit tunnel
J5W49_02925	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
J5W49_02930	COG0051	transcription antitermination factor activity, RNA binding
J5W49_02935	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
J5W49_02940	COG0049	tRNA binding
J5W49_02945	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
J5W49_02950	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
J5W49_02960	COG3852	Histidine kinase
J5W49_02965	COG2204	response regulator
J5W49_02975	COG1722	exodeoxyribonuclease VII activity
J5W49_02980	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
J5W49_02995	COG0795	lipopolysaccharide-transporting ATPase activity
J5W49_03000	COG1160	GTP binding
J5W49_03005	COG0444	Belongs to the ABC transporter superfamily
J5W49_03035	COG0577	efflux transmembrane transporter activity
J5W49_03035	COG1136	(ABC) transporter
J5W49_03040	COG4774	siderophore transport
J5W49_03090	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
J5W49_03095	COG0799	negative regulation of ribosome biogenesis
J5W49_03100	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
J5W49_03165	COG1136	(ABC) transporter
J5W49_03180	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
J5W49_03200	COG1077	Cell shape determining protein MreB Mrl
J5W49_03205	COG1530	ribonuclease E activity
J5W49_03235	COG0848	biopolymer transport protein
J5W49_03250	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
J5W49_03265	COG0134	indole-3-glycerol-phosphate synthase activity
J5W49_03275	COG0792	nuclease activity
J5W49_03285	COG1253	flavin adenine dinucleotide binding
J5W49_03295	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
J5W49_03300	COG0137	argininosuccinate synthase activity
J5W49_03305	COG3119	arylsulfatase activity
J5W49_03315	COG0149	triose-phosphate isomerase activity
J5W49_03355	COG1040	competence protein
J5W49_03365	COG3956	TIGRFAM MazG family protein
J5W49_03405	COG1663	tetraacyldisaccharide 4'-kinase activity
J5W49_03410	COG0612	Peptidase, M16
J5W49_03440	COG0673	inositol 2-dehydrogenase activity
J5W49_03445	COG3034	peptidoglycan biosynthetic process
J5W49_03465	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
J5W49_03470	COG0424	maF-like protein
J5W49_03475	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
J5W49_03495	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
J5W49_03505	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
J5W49_03515	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
J5W49_03525	COG0571	ribonuclease III activity
J5W49_03540	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
J5W49_03555	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
J5W49_03560	COG0470	DNA polymerase III
J5W49_03585	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
J5W49_03600	COG2226	methyltransferase
J5W49_03620	COG2942	2-epimerase
J5W49_03720	COG0535	radical SAM domain protein
J5W49_03785	COG3525	Glycosyl hydrolase, family 20, catalytic domain
J5W49_03790	COG2255	four-way junction helicase activity
J5W49_03795	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
J5W49_03800	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
J5W49_03805	COG1216	Glycosyl transferase, family 2
J5W49_03810	COG1215	transferase activity, transferring glycosyl groups
J5W49_03820	COG0438	transferase activity, transferring glycosyl groups
J5W49_03825	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
J5W49_03855	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
J5W49_03865	COG2860	membrane
J5W49_03870	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
J5W49_03875	COG2001	Belongs to the MraZ family
J5W49_03880	COG0275	rRNA processing
J5W49_03895	COG0768	penicillin binding
J5W49_03900	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
J5W49_03905	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
J5W49_03910	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
J5W49_03915	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
J5W49_03925	COG0772	Belongs to the SEDS family
J5W49_03930	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
J5W49_03935	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
J5W49_03940	COG1181	Belongs to the D-alanine--D-alanine ligase family
J5W49_03950	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
J5W49_03960	COG0860	N-Acetylmuramoyl-L-alanine amidase
J5W49_03965	COG0321	lipoyl(octanoyl) transferase activity
J5W49_03970	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
J5W49_03975	COG0066	3-isopropylmalate dehydratase activity
J5W49_03985	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
J5W49_04010	COG4608	Belongs to the ABC transporter superfamily
J5W49_04020	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
J5W49_04025	COG0052	Belongs to the universal ribosomal protein uS2 family
J5W49_04030	COG0534	Mate efflux family protein
J5W49_04050	COG2877	3-deoxy-8-phosphooctulonate synthase activity
J5W49_04065	COG1137	ATPase activity
J5W49_04075	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
J5W49_04110	COG0017	Asparaginyl-tRNA synthetase
J5W49_04130	COG3118	belongs to the thioredoxin family
J5W49_04175	COG0583	DNA-binding transcription factor activity
J5W49_04180	COG2855	membrane
J5W49_04185	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
J5W49_04195	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
J5W49_04205	COG0602	queuosine metabolic process
J5W49_04210	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
J5W49_04215	COG0217	transcriptional regulatory protein
J5W49_04230	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
J5W49_04235	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
J5W49_04240	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
J5W49_04240	COG4651	solute:proton antiporter activity
J5W49_04250	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
J5W49_04255	COG4864	UPF0365 protein
J5W49_04265	COG2022	thiamine diphosphate biosynthetic process
J5W49_04295	COG0531	amino acid
J5W49_04300	COG0546	phosphoglycolate phosphatase activity
J5W49_04305	COG0628	permease
J5W49_04315	COG3250	beta-galactosidase activity
J5W49_04325	COG0191	fructose-bisphosphate aldolase activity
J5W49_04370	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
J5W49_04380	COG1181	Belongs to the D-alanine--D-alanine ligase family
J5W49_04395	COG3209	COG3209 Rhs family protein
J5W49_04410	COG2096	Adenosyltransferase
J5W49_04420	COG2814	Major facilitator Superfamily
J5W49_04430	COG1690	Belongs to the RtcB family
J5W49_04470	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
J5W49_04475	COG3409	Peptidoglycan-binding domain 1 protein
J5W49_04475	COG5632	N-Acetylmuramoyl-L-alanine amidase
J5W49_04480	COG0656	L-ascorbic acid biosynthetic process
J5W49_04520	COG0022	dehydrogenase e1 component
J5W49_04525	COG0508	dehydrogenase complex catalyzes the overall conversion of
J5W49_04570	COG0321	lipoyl(octanoyl) transferase activity
J5W49_04570	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
J5W49_04575	COG0497	DNA recombination
J5W49_04580	COG2217	Heavy metal translocating P-type atpase
J5W49_04590	COG0657	acetylesterase activity
J5W49_04590	COG2755	lipolytic protein G-D-S-L family
J5W49_04605	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
J5W49_04610	COG1970	mechanosensitive ion channel activity
J5W49_04615	COG1785	Belongs to the alkaline phosphatase family
J5W49_04625	COG3525	Glycosyl hydrolase, family 20, catalytic domain
J5W49_04630	COG1363	Peptidase, m42
J5W49_04640	COG1592	Rubrerythrin
J5W49_04710	COG3345	alpha-galactosidase
J5W49_04735	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
J5W49_04740	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
J5W49_04750	COG3481	metal-dependent phosphohydrolase, HD sub domain
J5W49_04760	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
J5W49_04765	COG0148	phosphopyruvate hydratase activity
J5W49_04805	COG0165	Argininosuccinate lyase
J5W49_04810	COG0659	secondary active sulfate transmembrane transporter activity
J5W49_04815	COG1733	regulation of RNA biosynthetic process
J5W49_04825	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
J5W49_04860	COG0542	response to heat
J5W49_04880	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
J5W49_04890	COG0745	RESPONSE REGULATOR receiver
J5W49_04895	COG2205	protein histidine kinase activity
J5W49_04925	COG3250	beta-galactosidase activity
J5W49_04935	COG0084	hydrolase, TatD family'
J5W49_04975	COG0592	DNA-directed DNA polymerase activity
J5W49_04980	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
J5W49_04985	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
J5W49_04985	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
J5W49_04995	COG0445	tRNA wobble uridine modification
J5W49_05005	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
J5W49_05010	COG0440	acetolactate synthase activity
J5W49_05015	COG1643	Atp-dependent helicase
J5W49_05025	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
J5W49_05040	COG0107	imidazoleglycerol-phosphate synthase activity
J5W49_05055	COG1733	regulation of RNA biosynthetic process
J5W49_05065	COG0674	pyruvate-flavodoxin oxidoreductase activity
J5W49_05065	COG1013	pyruvate-flavodoxin oxidoreductase activity
J5W49_05065	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
J5W49_05065	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
J5W49_05070	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
J5W49_05095	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
J5W49_05100	COG1073	alpha beta
J5W49_05105	COG1073	alpha beta
J5W49_05120	COG0535	radical SAM domain protein
J5W49_05125	COG0535	radical SAM domain protein
J5W49_05130	COG2873	o-acetylhomoserine
J5W49_05155	COG0473	3-isopropylmalate dehydrogenase activity
J5W49_05170	COG2755	lipolytic protein G-D-S-L family
J5W49_05170	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
J5W49_05175	COG1028	Short-chain dehydrogenase reductase Sdr
J5W49_05205	COG0477	Major facilitator Superfamily
J5W49_05215	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
J5W49_05220	COG0588	phosphoglycerate mutase activity
J5W49_05265	COG0745	RESPONSE REGULATOR receiver
J5W49_05270	COG0471	metal ion transport
J5W49_05270	COG0490	domain, Protein
J5W49_05305	COG1216	Glycosyl transferase, family 2
J5W49_05310	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
J5W49_05320	COG1442	glycosyl transferase family 8
J5W49_05320	COG1216	Glycosyl transferase, family 2
J5W49_05335	COG1408	metallophosphoesterase
J5W49_05350	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
J5W49_05355	COG0196	riboflavin kinase activity
J5W49_05360	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
J5W49_05375	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
J5W49_05390	COG0546	phosphoglycolate phosphatase activity
J5W49_05400	COG0518	GMP synthase (glutamine-hydrolyzing) activity
J5W49_05400	COG0519	Catalyzes the synthesis of GMP from XMP
J5W49_05405	COG0517	IMP dehydrogenase activity
J5W49_05405	COG0516	GMP reductase activity
J5W49_05440	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
J5W49_05485	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
J5W49_05495	COG0557	exoribonuclease II activity
J5W49_05500	COG0826	peptidase U32
J5W49_05505	COG0285	dihydrofolate synthase activity
J5W49_05520	COG0673	inositol 2-dehydrogenase activity
J5W49_05525	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
J5W49_05530	COG0737	Belongs to the 5'-nucleotidase family
J5W49_05540	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
J5W49_05545	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
J5W49_05560	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
J5W49_05565	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
J5W49_05570	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
J5W49_05575	COG0200	Binds to the 23S rRNA
J5W49_05580	COG0201	protein transport
J5W49_05585	COG0563	adenylate kinase activity
J5W49_05590	COG0024	Methionine aminopeptidase
J5W49_05605	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
J5W49_05625	COG1442	glycosyl transferase family 8
J5W49_05630	COG1216	Glycosyl transferase, family 2
J5W49_05635	COG1216	Glycosyl transferase, family 2
J5W49_05640	COG1216	Glycosyl transferase, family 2
J5W49_05645	COG0693	protein deglycase activity
J5W49_05650	COG0508	dehydrogenase complex catalyzes the overall conversion of
J5W49_05655	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
J5W49_05665	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
J5W49_05675	COG1966	Carbon starvation protein
J5W49_05685	COG3119	arylsulfatase activity
J5W49_05690	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
J5W49_05695	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
J5W49_05700	COG0195	Participates in both transcription termination and antitermination
J5W49_05705	COG0708	Exodeoxyribonuclease III
J5W49_05710	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
J5W49_05715	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
J5W49_05725	COG2006	4fe-4S ferredoxin, iron-sulfur binding domain protein
J5W49_05730	COG0348	domain, Protein
J5W49_05745	COG0842	Transport permease protein
J5W49_05745	COG1131	(ABC) transporter
J5W49_05745	COG1716	ATPase activity
J5W49_05765	COG0724	RNA recognition motif
J5W49_05770	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
J5W49_05790	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
J5W49_05800	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
J5W49_05805	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
J5W49_05820	COG1490	D-aminoacyl-tRNA deacylase activity
J5W49_05825	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
J5W49_05830	COG1053	succinate dehydrogenase
J5W49_05860	COG1262	PFAM Formylglycine-generating sulfatase enzyme
J5W49_05865	COG1028	Short-chain dehydrogenase reductase Sdr
J5W49_05875	COG0488	(ABC) transporter
J5W49_05885	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
J5W49_05895	COG3119	arylsulfatase activity
J5W49_05915	COG0175	sulfate reduction
J5W49_05920	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
J5W49_05940	COG2267	carboxylic ester hydrolase activity
J5W49_05945	COG2095	MarC family integral membrane protein
J5W49_05950	COG0456	acetyltransferase
J5W49_05980	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
J5W49_05985	COG0488	(ABC) transporter
J5W49_05995	COG0697	spore germination
J5W49_06005	COG0215	cysteine-tRNA ligase activity
J5W49_06015	COG3119	arylsulfatase activity
J5W49_06045	COG0481	GTPase activity
J5W49_06065	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
J5W49_06070	COG0085	RNA polymerase activity
J5W49_06075	COG0222	ribosome binding
J5W49_06080	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
J5W49_06085	COG0081	regulation of translation
J5W49_06090	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
J5W49_06095	COG0250	Participates in transcription elongation, termination and antitermination
J5W49_06110	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
J5W49_06120	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
J5W49_06125	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
J5W49_06130	COG0740	serine-type endopeptidase activity
J5W49_06135	COG0544	peptidyl-prolyl cis-trans isomerase activity
J5W49_06150	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
J5W49_06170	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
J5W49_06235	COG2226	methyltransferase
J5W49_06240	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
J5W49_06245	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
J5W49_06255	COG3119	arylsulfatase activity
J5W49_06260	COG0514	ATP-dependent DNA helicase (RecQ)
J5W49_06275	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
J5W49_06280	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
J5W49_06315	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
J5W49_06335	COG1858	cytochrome C peroxidase
J5W49_06340	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
J5W49_06345	COG0590	tRNA wobble adenosine to inosine editing
J5W49_06350	COG1940	carbohydrate kinase activity
J5W49_06355	COG2217	Heavy metal translocating P-type atpase
J5W49_06360	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
J5W49_06365	COG0237	dephospho-CoA kinase activity
J5W49_06400	COG1363	Peptidase, m42
J5W49_06405	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
J5W49_06415	COG0006	proline dipeptidase activity
J5W49_06420	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
J5W49_06450	COG5002	protein histidine kinase activity
J5W49_06455	COG0745	RESPONSE REGULATOR receiver
J5W49_06460	COG0129	dihydroxy-acid dehydratase activity
J5W49_06490	COG1368	sulfuric ester hydrolase activity
J5W49_06510	COG1482	cell wall glycoprotein biosynthetic process
J5W49_06520	COG1757	Na H antiporter
J5W49_06525	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
J5W49_06530	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
J5W49_06535	COG0505	Belongs to the CarA family
J5W49_06540	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
J5W49_06550	COG0069	glutamate synthase activity
J5W49_06550	COG0067	glutamate synthase
J5W49_06550	COG0070	glutamate synthase
J5W49_06575	COG4106	trans-aconitate 2-methyltransferase activity
J5W49_06580	COG3525	Glycosyl hydrolase, family 20, catalytic domain
J5W49_06595	COG0038	chloride channel
J5W49_06615	COG4221	oxidoreductase activity
J5W49_06635	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
J5W49_06645	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
J5W49_06650	COG0047	phosphoribosylformylglycinamidine synthase activity
J5W49_06660	COG1363	Peptidase, m42
J5W49_06670	COG0753	catalase activity
J5W49_06680	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
J5W49_06685	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
J5W49_06715	COG0517	IMP dehydrogenase activity
J5W49_06715	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
J5W49_06720	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
J5W49_06770	COG0356	it plays a direct role in the translocation of protons across the membrane
J5W49_06780	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
J5W49_06790	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
J5W49_06795	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
J5W49_06800	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
J5W49_06805	COG0355	proton-transporting ATP synthase activity, rotational mechanism
J5W49_06850	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
J5W49_06890	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
J5W49_06915	COG0719	Fe-S assembly protein
J5W49_06920	COG0396	ATPase activity
J5W49_06925	COG0735	belongs to the Fur family
J5W49_06930	COG0211	Belongs to the bacterial ribosomal protein bL27 family
J5W49_06935	COG0261	This protein binds to 23S rRNA in the presence of protein L20
J5W49_06940	COG0802	atpase or kinase
J5W49_06945	COG1073	alpha beta
J5W49_06985	COG5434	Belongs to the glycosyl hydrolase 28 family
J5W49_06995	COG2326	polyphosphate kinase activity
J5W49_07010	COG0742	ribosomal rna small subunit methyltransferase
J5W49_07030	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
J5W49_07045	COG1349	DNA-binding transcription factor activity
J5W49_07050	COG2326	polyphosphate kinase activity
J5W49_07070	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
J5W49_07100	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
J5W49_07145	COG3119	arylsulfatase activity
J5W49_07160	COG3119	arylsulfatase activity
J5W49_07170	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
J5W49_07170	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
J5W49_07185	COG0012	GTP binding
J5W49_07190	COG1686	Belongs to the peptidase S11 family
J5W49_07205	COG0758	DNA mediated transformation
J5W49_07220	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
J5W49_07225	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
J5W49_07230	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
J5W49_07235	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
J5W49_07255	COG0456	acetyltransferase
J5W49_07265	COG1546	Belongs to the CinA family
J5W49_07265	COG1058	Belongs to the CinA family
J5W49_07280	COG0820	rRNA (adenine-C2-)-methyltransferase activity
J5W49_07285	COG0552	protein localization to endoplasmic reticulum
J5W49_07290	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
J5W49_07295	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
J5W49_07300	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
J5W49_07300	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
J5W49_07305	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
J5W49_07320	COG2814	Major facilitator Superfamily
J5W49_07335	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
J5W49_07340	COG0828	Belongs to the bacterial ribosomal protein bS21 family
J5W49_07350	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
J5W49_07365	COG3525	Glycosyl hydrolase, family 20, catalytic domain
J5W49_07390	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
J5W49_07395	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
J5W49_07405	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
J5W49_07410	COG1136	(ABC) transporter
J5W49_07415	COG2234	aminopeptidase activity
J5W49_07430	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
J5W49_07445	COG4968	Prepilin-type N-terminal cleavage methylation domain
J5W49_07460	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
J5W49_07465	COG0101	tRNA pseudouridine synthase activity
J5W49_07490	COG0110	maltose O-acetyltransferase activity
J5W49_07495	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
J5W49_07500	COG1309	transcriptional regulator
J5W49_07520	COG1185	polyribonucleotide nucleotidyltransferase activity
J5W49_07525	COG2207	Transcriptional regulator
J5W49_07535	COG0697	spore germination
J5W49_07545	COG2814	Major facilitator Superfamily
J5W49_07550	COG2311	Membrane
J5W49_07560	COG1253	flavin adenine dinucleotide binding
J5W49_07565	COG1253	flavin adenine dinucleotide binding
J5W49_07590	COG0167	dihydroorotate dehydrogenase activity
J5W49_07605	COG0519	Catalyzes the synthesis of GMP from XMP
J5W49_07610	COG3468	outer membrane autotransporter barrel domain protein
J5W49_07615	COG0076	glutamate decarboxylase activity
J5W49_07650	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
J5W49_07655	COG0562	UDP-galactopyranose mutase
J5W49_07660	COG0562	UDP-galactopyranose mutase
J5W49_07665	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
J5W49_07685	COG0534	Mate efflux family protein
J5W49_07690	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
J5W49_07715	COG1403	HNH endonuclease
J5W49_07755	COG0556	nucleotide-excision repair
J5W49_07880	COG0443	Heat shock 70 kDa protein
J5W49_07885	COG0443	Heat shock 70 kDa protein
J5W49_07920	COG1373	ATPase (AAA superfamily
J5W49_08015	COG1131	(ABC) transporter
J5W49_08025	COG0714	Associated with various cellular activities
J5W49_08035	COG1881	PFAM PEBP family protein
J5W49_08065	COG1090	epimerase
J5W49_08075	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
J5W49_08080	COG1119	ATPase activity
J5W49_08085	COG2186	Transcriptional regulator
J5W49_08120	COG0148	phosphopyruvate hydratase activity
J5W49_08135	COG0436	Aminotransferase
J5W49_08165	COG0227	Belongs to the bacterial ribosomal protein bL28 family
J5W49_08180	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
J5W49_08200	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
J5W49_08210	COG1199	ATP-dependent helicase activity
J5W49_08220	COG1122	ATPase activity
J5W49_08245	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
J5W49_08250	COG0598	Magnesium transport protein CorA
J5W49_08255	COG0359	binds to the 23S rRNA
J5W49_08260	COG0138	bifunctional purine biosynthesis protein purh
J5W49_08265	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
J5W49_08270	COG0736	holo-[acyl-carrier-protein] synthase activity
J5W49_08285	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
J5W49_08295	COG5632	N-Acetylmuramoyl-L-alanine amidase
J5W49_08295	COG3409	Peptidoglycan-binding domain 1 protein
J5W49_08300	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
J5W49_08315	COG0437	4 iron, 4 sulfur cluster binding
J5W49_08340	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
J5W49_08380	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
J5W49_08385	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
J5W49_08390	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
J5W49_08395	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
J5W49_08415	COG1442	glycosyl transferase family 8
J5W49_08460	COG0539	negative regulation of cytoplasmic translation
J5W49_08475	COG0336	Belongs to the RNA methyltransferase TrmD family
J5W49_08485	COG1187	pseudouridine synthase activity
J5W49_08495	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
J5W49_08505	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
J5W49_08510	COG1393	Belongs to the ArsC family
J5W49_08515	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
J5W49_08525	COG1063	alcohol dehydrogenase
J5W49_08530	COG0242	peptide deformylase activity
J5W49_08540	COG1028	Short-chain dehydrogenase reductase Sdr
J5W49_08630	COG0351	phosphomethylpyrimidine kinase
J5W49_08640	COG0471	metal ion transport
J5W49_08670	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
J5W49_08685	COG0028	Belongs to the TPP enzyme family
J5W49_08690	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
J5W49_08700	COG0205	6-phosphofructokinase activity
J5W49_08710	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
J5W49_08720	COG0427	acetyl-CoA hydrolase
J5W49_08730	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
J5W49_08750	COG0346	lactoylglutathione lyase activity
J5W49_08760	COG0335	large ribosomal subunit rRNA binding
J5W49_08780	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
J5W49_08800	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
J5W49_08805	COG0657	acetylesterase activity
J5W49_08805	COG2755	lipolytic protein G-D-S-L family
J5W49_08810	COG2234	aminopeptidase activity
J5W49_08860	COG4591	ABC-type transport system involved in lipoprotein release permease component
J5W49_08870	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
J5W49_08875	COG0546	phosphoglycolate phosphatase activity
J5W49_08880	COG1322	Protein conserved in bacteria
J5W49_08890	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
J5W49_08895	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
J5W49_08915	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
J5W49_08920	COG0504	CTP synthase activity
J5W49_08925	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
J5W49_08985	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
J5W49_08990	COG1127	ABC transporter
J5W49_09005	COG1132	(ABC) transporter
J5W49_09010	COG1132	(ABC) transporter
J5W49_09015	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
J5W49_09030	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
J5W49_09075	COG0601	transmembrane transport
J5W49_09080	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
J5W49_09095	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
J5W49_09130	COG1475	DNA binding
J5W49_09180	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
J5W49_09180	COG1918	ferrous iron import across plasma membrane
J5W49_09190	COG3119	arylsulfatase activity
J5W49_09200	COG0750	zinc metalloprotease
J5W49_09220	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
J5W49_09265	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
J5W49_09270	COG0540	Belongs to the ATCase OTCase family
J5W49_09275	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
J5W49_09280	COG1720	tRNA m6t6A37 methyltransferase activity
J5W49_09295	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
J5W49_09345	COG1538	Outer membrane efflux protein
J5W49_09350	COG0577	efflux transmembrane transporter activity
J5W49_09350	COG1136	(ABC) transporter
J5W49_09355	COG1136	(ABC) transporter
J5W49_09355	COG0577	efflux transmembrane transporter activity
J5W49_09375	COG0494	nUDIX hydrolase
J5W49_09385	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
J5W49_09385	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
J5W49_09390	COG1940	carbohydrate kinase activity
J5W49_09395	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
J5W49_09400	COG0267	Belongs to the bacterial ribosomal protein bL33 family
J5W49_09405	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
J5W49_09410	COG1469	GTP cyclohydrolase I activity
J5W49_09420	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
J5W49_09425	COG0181	hydroxymethylbilane synthase activity
J5W49_09430	COG3189	MarR family transcriptional regulator
J5W49_09445	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
J5W49_09505	COG0515	serine threonine protein kinase
J5W49_09505	COG2815	serine threonine protein kinase
J5W49_09520	COG0156	8-amino-7-oxononanoate synthase activity
J5W49_09535	COG2816	NAD+ diphosphatase activity
J5W49_09540	COG0738	Major facilitator superfamily
J5W49_09545	COG0246	Mannitol dehydrogenase
J5W49_09550	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
J5W49_09565	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
J5W49_09570	COG1692	metallophosphoesterase
J5W49_09580	COG0180	Tryptophanyl-tRNA synthetase
J5W49_09595	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
J5W49_09610	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
J5W49_09630	COG0542	response to heat
J5W49_09635	COG3869	Catalyzes the specific phosphorylation of arginine residues in
J5W49_09640	COG3880	PFAM UvrB UvrC protein
J5W49_09645	COG1108	ABC-type Mn2 Zn2 transport systems permease components
J5W49_09650	COG1121	(ABC) transporter
J5W49_09675	COG3525	Glycosyl hydrolase, family 20, catalytic domain
J5W49_09680	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
J5W49_09690	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
J5W49_09700	COG1216	Glycosyl transferase, family 2
J5W49_09715	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
J5W49_09720	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
J5W49_09735	COG3206	protein involved in exopolysaccharide biosynthesis
J5W49_09735	COG0489	protein tyrosine kinase activity
J5W49_09740	COG0438	transferase activity, transferring glycosyl groups
J5W49_09745	COG0438	transferase activity, transferring glycosyl groups
J5W49_09750	COG1216	Glycosyl transferase, family 2
J5W49_09780	COG0438	transferase activity, transferring glycosyl groups
J5W49_09785	COG1216	Glycosyl transferase, family 2
J5W49_09785	COG1442	glycosyl transferase family 8
J5W49_09790	COG0438	transferase activity, transferring glycosyl groups
J5W49_09795	COG1216	Glycosyl transferase, family 2
J5W49_09795	COG1442	glycosyl transferase family 8
J5W49_09800	COG0438	transferase activity, transferring glycosyl groups
J5W49_09805	COG1216	Glycosyl transferase, family 2
J5W49_09835	COG0534	Mate efflux family protein
J5W49_09840	COG2226	methyltransferase
J5W49_09855	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
J5W49_09860	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
J5W49_09865	COG2890	protein-(glutamine-N5) methyltransferase activity
J5W49_09870	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
J5W49_09885	COG1115	amino acid carrier protein
J5W49_09895	COG2066	Belongs to the glutaminase family
J5W49_09900	COG0531	amino acid
J5W49_09905	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
J5W49_09920	COG0038	chloride channel
J5W49_09935	COG4112	unkown
J5W49_09945	COG1538	Outer membrane efflux protein
J5W49_09955	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
J5W49_09960	COG0339	signal peptide processing
J5W49_09965	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
J5W49_10005	COG0489	protein tyrosine kinase activity
J5W49_10010	COG0534	Mate efflux family protein
J5W49_10020	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
J5W49_10025	COG1312	Catalyzes the dehydration of D-mannonate
J5W49_10030	COG1904	glucuronate isomerase
J5W49_10035	COG0800	Aldolase
J5W49_10050	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
J5W49_10055	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
J5W49_10085	COG1070	Carbohydrate kinase
J5W49_10100	COG0738	Major facilitator superfamily
J5W49_10130	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
J5W49_10150	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
J5W49_10155	COG0232	Belongs to the dGTPase family. Type 2 subfamily
J5W49_10160	COG2132	Multicopper oxidase
J5W49_10190	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
J5W49_10195	COG4608	Belongs to the ABC transporter superfamily
J5W49_10200	COG0444	Belongs to the ABC transporter superfamily
J5W49_10205	COG4166	transmembrane transport
J5W49_10210	COG4239	(ABC) transporter, permease
J5W49_10215	COG0601	transmembrane transport
J5W49_10230	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
J5W49_10235	COG2759	Belongs to the formate--tetrahydrofolate ligase family
J5W49_10475	COG2304	oxidoreductase activity
J5W49_10490	COG0714	Associated with various cellular activities
J5W49_10495	COG0154	amidase activity
J5W49_10500	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
J5W49_10535	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
J5W49_10540	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
J5W49_10575	COG1294	oxidase, subunit
J5W49_10580	COG1271	oxidase subunit
J5W49_10590	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
J5W49_10620	COG1528	Iron-storage protein
J5W49_10655	COG2949	membrane
J5W49_10660	COG1051	belongs to the nudix hydrolase family
J5W49_10670	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
J5W49_10680	COG0489	protein tyrosine kinase activity
J5W49_10745	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
J5W49_10745	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
J5W49_10770	COG0514	ATP-dependent DNA helicase (RecQ)
J5W49_10805	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
J5W49_10810	COG0045	succinate-CoA ligase (ADP-forming) activity
J5W49_10815	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
J5W49_10850	COG1570	exodeoxyribonuclease VII activity
J5W49_10885	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
J5W49_10890	COG2205	protein histidine kinase activity
J5W49_10905	COG0113	porphobilinogen synthase activity
J5W49_10915	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
J5W49_10930	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
J5W49_10930	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
J5W49_10960	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
J5W49_10965	COG0778	Nitroreductase
J5W49_10975	COG1335	isochorismatase
J5W49_11005	COG0375	protein maturation
J5W49_11010	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
J5W49_11020	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
J5W49_11050	COG2195	Cleaves the N-terminal amino acid of tripeptides
J5W49_11060	COG0281	malic enzyme
J5W49_11060	COG0280	phosphate acetyltransferase
J5W49_11070	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
J5W49_11080	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
J5W49_11110	COG1216	Glycosyl transferase, family 2
J5W49_11115	COG1215	transferase activity, transferring glycosyl groups
J5W49_11125	COG0463	Glycosyl transferase, family 2
J5W49_11130	COG0110	maltose O-acetyltransferase activity
J5W49_11140	COG0438	transferase activity, transferring glycosyl groups
J5W49_11170	COG1442	glycosyl transferase family 8
J5W49_11170	COG1216	Glycosyl transferase, family 2
J5W49_11175	COG1216	Glycosyl transferase, family 2
J5W49_11180	COG4464	protein tyrosine phosphatase activity
J5W49_11195	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
J5W49_11210	COG1592	Rubrerythrin
J5W49_11215	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
J5W49_11245	COG0753	catalase activity
J5W49_11260	COG1012	belongs to the aldehyde dehydrogenase family
J5W49_11265	COG3738	Protein conserved in bacteria
J5W49_11270	COG0151	Belongs to the GarS family
J5W49_11315	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
J5W49_11320	COG0352	thiamine-phosphate diphosphorylase activity
J5W49_11335	COG1959	2 iron, 2 sulfur cluster binding
J5W49_11340	COG0629	single-stranded DNA binding
J5W49_11350	COG0811	peptide transport
J5W49_11360	COG0242	peptide deformylase activity
J5W49_11370	COG0640	Transcriptional regulator
J5W49_11445	COG0538	isocitrate dehydrogenase activity
J5W49_11465	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
J5W49_11470	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
J5W49_11475	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
J5W49_11480	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
J5W49_11485	COG0668	transmembrane transport
J5W49_11490	COG0724	RNA recognition motif
J5W49_11500	COG0805	protein transport
J5W49_11505	COG1968	undecaprenyl-diphosphatase activity
J5W49_11520	COG0745	RESPONSE REGULATOR receiver
J5W49_11525	COG5002	protein histidine kinase activity
J5W49_11595	COG1408	metallophosphoesterase
J5W49_11605	COG1090	epimerase
J5W49_11625	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
J5W49_11635	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
J5W49_11645	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
J5W49_11655	COG1454	alcohol dehydrogenase
J5W49_11665	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
J5W49_11665	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
J5W49_11670	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
J5W49_11680	COG0815	Transfers the fatty acyl group on membrane lipoproteins
J5W49_11725	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
J5W49_11725	COG0037	tRNA processing
J5W49_11735	COG0527	aspartate kinase activity
J5W49_11750	COG1741	Belongs to the pirin family
J5W49_11760	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
J5W49_11780	COG0363	glucosamine-6-phosphate deaminase activity
J5W49_11785	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
J5W49_11790	COG1837	Belongs to the UPF0109 family
J5W49_11805	COG1091	dTDP-4-dehydrorhamnose reductase activity
J5W49_11825	COG0534	Mate efflux family protein
J5W49_11845	COG0789	Transcriptional regulator
J5W49_11870	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
J5W49_11875	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
J5W49_11880	COG0789	Transcriptional regulator
J5W49_11885	COG1408	metallophosphoesterase
J5W49_11890	COG0656	L-ascorbic acid biosynthetic process
J5W49_11900	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
J5W49_11915	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
J5W49_11955	COG1410	methionine synthase
J5W49_11955	COG0646	methionine synthase
J5W49_11960	COG2966	Psort location CytoplasmicMembrane, score
J5W49_11965	COG3610	response to peptide
J5W49_11970	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
J5W49_11975	COG0732	type I restriction modification DNA specificity domain
J5W49_11980	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
J5W49_12010	COG1703	isobutyryl-CoA mutase activity
J5W49_12065	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
J5W49_12070	COG0513	Belongs to the DEAD box helicase family
J5W49_12075	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
J5W49_12080	COG0418	dihydroorotase activity
J5W49_12095	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
J5W49_12150	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
J5W49_12185	COG0714	Associated with various cellular activities
J5W49_12190	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
J5W49_12195	COG1194	a g-specific adenine glycosylase
J5W49_12200	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
J5W49_12210	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
J5W49_12210	COG0574	Belongs to the PEP-utilizing enzyme family
J5W49_12215	COG0166	Belongs to the GPI family
J5W49_12225	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
J5W49_12240	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
J5W49_12240	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
J5W49_12280	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
J5W49_12295	COG0515	serine threonine protein kinase
J5W49_12295	COG2815	serine threonine protein kinase
J5W49_12305	COG3033	Beta-eliminating lyase
J5W49_12320	COG0072	phenylalanine-tRNA ligase activity
J5W49_12320	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
J5W49_12335	COG3059	membrane
J5W49_12345	COG0326	Molecular chaperone. Has ATPase activity
J5W49_12350	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
J5W49_12380	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
J5W49_12385	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
J5W49_12385	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
J5W49_12405	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
J5W49_12410	COG1472	Belongs to the glycosyl hydrolase 3 family
J5W49_12415	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
J5W49_12430	COG0635	Involved in the biosynthesis of porphyrin-containing compound
J5W49_12455	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
J5W49_12460	COG1063	alcohol dehydrogenase
J5W49_12480	COG0714	Associated with various cellular activities
J5W49_12490	COG0193	aminoacyl-tRNA hydrolase activity
J5W49_12495	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
J5W49_12510	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
J5W49_12535	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
J5W49_12550	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
J5W49_12555	COG0512	Glutamine amidotransferase of anthranilate synthase
J5W49_12595	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
J5W49_12600	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
J5W49_12605	COG0586	Pfam SNARE associated Golgi protein
J5W49_12675	COG1518	maintenance of DNA repeat elements
J5W49_12700	COG0423	glycine-tRNA ligase activity
J5W49_12715	COG0436	Aminotransferase
J5W49_12720	COG1522	sequence-specific DNA binding
J5W49_12725	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
J5W49_12730	COG2967	ApaG domain
J5W49_12740	COG1215	transferase activity, transferring glycosyl groups
J5W49_12750	COG1678	Uncharacterized ACR, COG1678
J5W49_12755	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
J5W49_12770	COG1131	(ABC) transporter
J5W49_12775	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
J5W49_12780	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
J5W49_12785	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
J5W49_12790	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
J5W49_12795	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
J5W49_12805	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
J5W49_12820	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
J5W49_12850	COG4106	trans-aconitate 2-methyltransferase activity
J5W49_12865	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
J5W49_12890	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
J5W49_12895	COG2311	Membrane
J5W49_12925	COG3525	Glycosyl hydrolase, family 20, catalytic domain
J5W49_12930	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
J5W49_12935	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
J5W49_12950	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
J5W49_12955	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
J5W49_12990	COG0673	inositol 2-dehydrogenase activity
J5W49_12995	COG0339	signal peptide processing
J5W49_13005	COG0018	arginyl-trna synthetase
J5W49_13050	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
J5W49_13080	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
J5W49_13095	COG0653	protein targeting
J5W49_13100	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
J5W49_13100	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
J5W49_13330	COG0494	nUDIX hydrolase