locus-tag	class	description
AKKM5201_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AKKM5201_00010	COG1131	(ABC) transporter
AKKM5201_00030	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AKKM5201_00035	COG0564	pseudouridine synthase activity
AKKM5201_00050	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AKKM5201_00055	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AKKM5201_00070	COG0513	Belongs to the DEAD box helicase family
AKKM5201_00080	COG0673	inositol 2-dehydrogenase activity
AKKM5201_00095	COG2814	Major facilitator Superfamily
AKKM5201_00100	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
AKKM5201_00110	COG1971	Probably functions as a manganese efflux pump
AKKM5201_00135	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AKKM5201_00160	COG0442	prolyl-tRNA aminoacylation
AKKM5201_00195	COG0531	amino acid
AKKM5201_00200	COG2066	Belongs to the glutaminase family
AKKM5201_00215	COG1115	amino acid carrier protein
AKKM5201_00225	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
AKKM5201_00230	COG2890	protein-(glutamine-N5) methyltransferase activity
AKKM5201_00235	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
AKKM5201_00240	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
AKKM5201_00260	COG2226	methyltransferase
AKKM5201_00265	COG0534	Mate efflux family protein
AKKM5201_00340	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AKKM5201_00345	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
AKKM5201_00355	COG3525	Glycosyl hydrolase, family 20, catalytic domain
AKKM5201_00370	COG1121	(ABC) transporter
AKKM5201_00375	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AKKM5201_00380	COG3880	PFAM UvrB UvrC protein
AKKM5201_00385	COG3869	Catalyzes the specific phosphorylation of arginine residues in
AKKM5201_00390	COG0542	response to heat
AKKM5201_00405	COG0179	Fumarylacetoacetate (FAA) hydrolase
AKKM5201_00410	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AKKM5201_00425	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
AKKM5201_00425	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
AKKM5201_00435	COG0180	Tryptophanyl-tRNA synthetase
AKKM5201_00445	COG1692	metallophosphoesterase
AKKM5201_00455	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
AKKM5201_00590	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AKKM5201_00600	COG2816	NAD+ diphosphatase activity
AKKM5201_00610	COG0156	8-amino-7-oxononanoate synthase activity
AKKM5201_00620	COG1192	Involved in chromosome partitioning
AKKM5201_00625	COG3266	domain, Protein
AKKM5201_00625	COG0515	serine threonine protein kinase
AKKM5201_00880	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
AKKM5201_00890	COG3189	MarR family transcriptional regulator
AKKM5201_00895	COG0181	hydroxymethylbilane synthase activity
AKKM5201_00900	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
AKKM5201_00910	COG1469	GTP cyclohydrolase I activity
AKKM5201_00915	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
AKKM5201_00920	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AKKM5201_00925	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
AKKM5201_00930	COG1940	carbohydrate kinase activity
AKKM5201_00945	COG0494	nUDIX hydrolase
AKKM5201_00950	COG1566	PFAM secretion protein HlyD family protein
AKKM5201_00955	COG1136	(ABC) transporter
AKKM5201_00955	COG0577	efflux transmembrane transporter activity
AKKM5201_00960	COG1136	(ABC) transporter
AKKM5201_00960	COG0577	efflux transmembrane transporter activity
AKKM5201_00965	COG1538	Outer membrane efflux protein
AKKM5201_00980	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AKKM5201_00990	COG1720	tRNA m6t6A37 methyltransferase activity
AKKM5201_00995	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AKKM5201_01000	COG0540	Belongs to the ATCase OTCase family
AKKM5201_01005	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
AKKM5201_01020	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
AKKM5201_01025	COG2957	Belongs to the agmatine deiminase family
AKKM5201_01035	COG0750	zinc metalloprotease
AKKM5201_01045	COG3119	arylsulfatase activity
AKKM5201_01055	COG1918	ferrous iron import across plasma membrane
AKKM5201_01055	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
AKKM5201_01120	COG1475	DNA binding
AKKM5201_01155	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AKKM5201_01175	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AKKM5201_01180	COG0601	transmembrane transport
AKKM5201_01220	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AKKM5201_01235	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AKKM5201_01240	COG1132	(ABC) transporter
AKKM5201_01245	COG1132	(ABC) transporter
AKKM5201_01260	COG1127	ABC transporter
AKKM5201_01265	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
AKKM5201_01300	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AKKM5201_01315	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
AKKM5201_01320	COG0504	CTP synthase activity
AKKM5201_01325	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AKKM5201_01350	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AKKM5201_01360	COG1322	Protein conserved in bacteria
AKKM5201_01365	COG0546	phosphoglycolate phosphatase activity
AKKM5201_01370	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AKKM5201_01380	COG4591	ABC-type transport system involved in lipoprotein release permease component
AKKM5201_01380	COG4591	ABC-type transport system involved in lipoprotein release permease component
AKKM5201_01390	COG4104	PAAR repeat-containing protein
AKKM5201_01390	COG3209	COG3209 Rhs family protein
AKKM5201_01395	COG3209	COG3209 Rhs family protein
AKKM5201_01440	COG2234	aminopeptidase activity
AKKM5201_01445	COG2755	lipolytic protein G-D-S-L family
AKKM5201_01445	COG0657	acetylesterase activity
AKKM5201_01450	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AKKM5201_01470	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AKKM5201_01490	COG0335	large ribosomal subunit rRNA binding
AKKM5201_01500	COG0346	lactoylglutathione lyase activity
AKKM5201_01515	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
AKKM5201_01520	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
AKKM5201_01530	COG0427	acetyl-CoA hydrolase
AKKM5201_01545	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
AKKM5201_01555	COG0205	6-phosphofructokinase activity
AKKM5201_01565	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AKKM5201_01570	COG0028	Belongs to the TPP enzyme family
AKKM5201_01590	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
AKKM5201_01605	COG0471	metal ion transport
AKKM5201_01620	COG0351	phosphomethylpyrimidine kinase
AKKM5201_01675	COG1028	Short-chain dehydrogenase reductase Sdr
AKKM5201_01685	COG0242	peptide deformylase activity
AKKM5201_01690	COG1063	alcohol dehydrogenase
AKKM5201_01700	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AKKM5201_01705	COG1393	Belongs to the ArsC family
AKKM5201_01710	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
AKKM5201_01720	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AKKM5201_01730	COG1187	pseudouridine synthase activity
AKKM5201_01740	COG0336	Belongs to the RNA methyltransferase TrmD family
AKKM5201_01745	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
AKKM5201_01755	COG0539	negative regulation of cytoplasmic translation
AKKM5201_01800	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
AKKM5201_01805	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
AKKM5201_01810	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
AKKM5201_01815	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AKKM5201_01855	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AKKM5201_02020	COG0305	Participates in initiation and elongation during chromosome replication
AKKM5201_02150	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
AKKM5201_02150	COG0662	Cupin 2, conserved barrel domain protein
AKKM5201_02160	COG0416	fatty acid biosynthetic process
AKKM5201_02165	COG0333	Belongs to the bacterial ribosomal protein bL32 family
AKKM5201_02175	COG0537	adenosine 5'-monophosphoramidase activity
AKKM5201_02180	COG0009	L-threonylcarbamoyladenylate synthase
AKKM5201_02185	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
AKKM5201_02190	COG0228	four-way junction DNA binding
AKKM5201_02215	COG1862	Preprotein translocase
AKKM5201_02220	COG0343	queuine tRNA-ribosyltransferase activity
AKKM5201_02225	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AKKM5201_02235	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
AKKM5201_02240	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AKKM5201_02245	COG0776	regulation of translation
AKKM5201_02280	COG0811	peptide transport
AKKM5201_02300	COG3250	beta-galactosidase activity
AKKM5201_02305	COG0525	valine-tRNA ligase activity
AKKM5201_02315	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
AKKM5201_02320	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
AKKM5201_02325	COG0255	Belongs to the universal ribosomal protein uL29 family
AKKM5201_02330	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
AKKM5201_02335	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
AKKM5201_02340	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
AKKM5201_02350	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AKKM5201_02355	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
AKKM5201_02360	COG0089	rRNA binding
AKKM5201_02365	COG0088	Forms part of the polypeptide exit tunnel
AKKM5201_02370	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
AKKM5201_02375	COG0051	transcription antitermination factor activity, RNA binding
AKKM5201_02380	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AKKM5201_02385	COG0049	tRNA binding
AKKM5201_02390	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
AKKM5201_02400	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
AKKM5201_02410	COG3852	Histidine kinase
AKKM5201_02415	COG2204	response regulator
AKKM5201_02425	COG1722	exodeoxyribonuclease VII activity
AKKM5201_02430	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
AKKM5201_02445	COG0795	lipopolysaccharide-transporting ATPase activity
AKKM5201_02450	COG1160	GTP binding
AKKM5201_02455	COG0444	Belongs to the ABC transporter superfamily
AKKM5201_02470	COG1136	(ABC) transporter
AKKM5201_02470	COG0577	efflux transmembrane transporter activity
AKKM5201_02480	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
AKKM5201_02525	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
AKKM5201_02535	COG0799	negative regulation of ribosome biogenesis
AKKM5201_02540	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AKKM5201_02595	COG1136	(ABC) transporter
AKKM5201_02595	COG0577	efflux transmembrane transporter activity
AKKM5201_02610	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
AKKM5201_02620	COG4221	oxidoreductase activity
AKKM5201_02640	COG0038	chloride channel
AKKM5201_02650	COG3525	Glycosyl hydrolase, family 20, catalytic domain
AKKM5201_02665	COG0076	glutamate decarboxylase activity
AKKM5201_02680	COG0167	dihydroorotate dehydrogenase activity
AKKM5201_02685	COG0352	thiamine-phosphate diphosphorylase activity
AKKM5201_02705	COG1253	flavin adenine dinucleotide binding
AKKM5201_02710	COG1253	flavin adenine dinucleotide binding
AKKM5201_02720	COG1185	polyribonucleotide nucleotidyltransferase activity
AKKM5201_02725	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
AKKM5201_02730	COG0110	maltose O-acetyltransferase activity
AKKM5201_02755	COG0101	tRNA pseudouridine synthase activity
AKKM5201_02760	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
AKKM5201_02780	COG4968	Prepilin-type N-terminal cleavage methylation domain
AKKM5201_02795	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
AKKM5201_02810	COG1136	(ABC) transporter
AKKM5201_02815	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
AKKM5201_02825	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AKKM5201_02835	COG1116	anion transmembrane transporter activity
AKKM5201_02850	COG3525	Glycosyl hydrolase, family 20, catalytic domain
AKKM5201_02855	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
AKKM5201_02860	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
AKKM5201_02875	COG0828	Belongs to the bacterial ribosomal protein bS21 family
AKKM5201_02880	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AKKM5201_02895	COG2814	Major facilitator Superfamily
AKKM5201_02910	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AKKM5201_02915	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AKKM5201_02915	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AKKM5201_02920	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
AKKM5201_02925	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AKKM5201_02930	COG0552	protein localization to endoplasmic reticulum
AKKM5201_02935	COG0820	rRNA (adenine-C2-)-methyltransferase activity
AKKM5201_02955	COG1546	Belongs to the CinA family
AKKM5201_02955	COG1058	Belongs to the CinA family
AKKM5201_02965	COG0456	acetyltransferase
AKKM5201_02990	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
AKKM5201_02995	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
AKKM5201_03000	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
AKKM5201_03005	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
AKKM5201_03020	COG0758	DNA mediated transformation
AKKM5201_03025	COG1686	Belongs to the peptidase S11 family
AKKM5201_03030	COG0012	GTP binding
AKKM5201_03045	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AKKM5201_03045	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AKKM5201_03060	COG3119	arylsulfatase activity
AKKM5201_03090	COG2259	Doxx family
AKKM5201_03095	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
AKKM5201_03125	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AKKM5201_03145	COG2326	polyphosphate kinase activity
AKKM5201_03150	COG1349	DNA-binding transcription factor activity
AKKM5201_03170	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AKKM5201_03175	COG1162	GTPase activity
AKKM5201_03190	COG0742	ribosomal rna small subunit methyltransferase
AKKM5201_03205	COG2326	polyphosphate kinase activity
AKKM5201_03220	COG5434	Belongs to the glycosyl hydrolase 28 family
AKKM5201_03230	COG1073	alpha beta
AKKM5201_03235	COG0802	atpase or kinase
AKKM5201_03245	COG0211	Belongs to the bacterial ribosomal protein bL27 family
AKKM5201_03250	COG0735	belongs to the Fur family
AKKM5201_03255	COG0396	ATPase activity
AKKM5201_03260	COG0719	Fe-S assembly protein
AKKM5201_03265	COG0719	Fe-S assembly protein
AKKM5201_03280	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
AKKM5201_03325	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
AKKM5201_03345	COG0355	proton-transporting ATP synthase activity, rotational mechanism
AKKM5201_03350	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
AKKM5201_03355	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
AKKM5201_03360	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
AKKM5201_03365	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AKKM5201_03370	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AKKM5201_03380	COG0356	it plays a direct role in the translocation of protons across the membrane
AKKM5201_03430	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AKKM5201_03465	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
AKKM5201_03470	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
AKKM5201_03475	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
AKKM5201_03490	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
AKKM5201_03500	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AKKM5201_03505	COG0047	phosphoribosylformylglycinamidine synthase activity
AKKM5201_03515	COG1363	Peptidase, m42
AKKM5201_03535	COG1077	Cell shape determining protein MreB Mrl
AKKM5201_03540	COG1530	ribonuclease E activity
AKKM5201_03570	COG0848	biopolymer transport protein
AKKM5201_03585	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AKKM5201_03605	COG0134	indole-3-glycerol-phosphate synthase activity
AKKM5201_03610	COG0792	nuclease activity
AKKM5201_03620	COG1253	flavin adenine dinucleotide binding
AKKM5201_03630	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
AKKM5201_03645	COG0137	argininosuccinate synthase activity
AKKM5201_03660	COG0149	triose-phosphate isomerase activity
AKKM5201_03695	COG1040	competence protein
AKKM5201_03705	COG3956	TIGRFAM MazG family protein
AKKM5201_03725	COG1663	tetraacyldisaccharide 4'-kinase activity
AKKM5201_03730	COG0612	Peptidase, M16
AKKM5201_03750	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
AKKM5201_03785	COG0673	inositol 2-dehydrogenase activity
AKKM5201_03790	COG3034	peptidoglycan biosynthetic process
AKKM5201_03810	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AKKM5201_03815	COG0424	maF-like protein
AKKM5201_03820	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AKKM5201_03850	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
AKKM5201_03860	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AKKM5201_03870	COG0571	ribonuclease III activity
AKKM5201_03880	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
AKKM5201_03970	COG0708	Exodeoxyribonuclease III
AKKM5201_03975	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
AKKM5201_03990	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
AKKM5201_04010	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AKKM5201_04025	COG2226	methyltransferase
AKKM5201_04035	COG2076	Multidrug Resistance protein
AKKM5201_04110	COG2255	four-way junction helicase activity
AKKM5201_04115	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AKKM5201_04120	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
AKKM5201_04125	COG1215	transferase activity, transferring glycosyl groups
AKKM5201_04155	COG1053	succinate dehydrogenase
AKKM5201_04160	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AKKM5201_04200	COG1490	D-aminoacyl-tRNA deacylase activity
AKKM5201_04215	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AKKM5201_04220	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
AKKM5201_04230	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AKKM5201_04250	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AKKM5201_04255	COG0724	RNA recognition motif
AKKM5201_04275	COG0842	Transport permease protein
AKKM5201_04275	COG1131	(ABC) transporter
AKKM5201_04275	COG1716	ATPase activity
AKKM5201_04285	COG2006	4fe-4S ferredoxin, iron-sulfur binding domain protein
AKKM5201_04290	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
AKKM5201_04295	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
AKKM5201_04300	COG0708	Exodeoxyribonuclease III
AKKM5201_04305	COG0195	Participates in both transcription termination and antitermination
AKKM5201_04310	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
AKKM5201_04315	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
AKKM5201_04320	COG3119	arylsulfatase activity
AKKM5201_04335	COG1442	glycosyl transferase family 8
AKKM5201_04335	COG1216	Glycosyl transferase, family 2
AKKM5201_04340	COG1216	Glycosyl transferase, family 2
AKKM5201_04345	COG1216	Glycosyl transferase, family 2
AKKM5201_04350	COG1216	Glycosyl transferase, family 2
AKKM5201_04360	COG0508	dehydrogenase complex catalyzes the overall conversion of
AKKM5201_04365	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
AKKM5201_04375	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AKKM5201_04385	COG1966	Carbon starvation protein
AKKM5201_04395	COG1442	glycosyl transferase family 8
AKKM5201_04400	COG1442	glycosyl transferase family 8
AKKM5201_04410	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
AKKM5201_04425	COG0024	Methionine aminopeptidase
AKKM5201_04430	COG0563	adenylate kinase activity
AKKM5201_04435	COG0201	protein transport
AKKM5201_04440	COG0200	Binds to the 23S rRNA
AKKM5201_04445	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
AKKM5201_04450	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
AKKM5201_04455	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
AKKM5201_04460	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
AKKM5201_04470	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
AKKM5201_04475	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AKKM5201_04485	COG0737	Belongs to the 5'-nucleotidase family
AKKM5201_04490	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AKKM5201_04495	COG0673	inositol 2-dehydrogenase activity
AKKM5201_04510	COG0285	dihydrofolate synthase activity
AKKM5201_04515	COG0826	peptidase U32
AKKM5201_04545	COG0557	exoribonuclease II activity
AKKM5201_04555	COG2096	Adenosyltransferase
AKKM5201_04565	COG2814	Major facilitator Superfamily
AKKM5201_04575	COG1690	Belongs to the RtcB family
AKKM5201_04600	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
AKKM5201_04605	COG5632	N-Acetylmuramoyl-L-alanine amidase
AKKM5201_04605	COG3409	Peptidoglycan-binding domain 1 protein
AKKM5201_04655	COG3210	domain, Protein
AKKM5201_04660	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AKKM5201_04665	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AKKM5201_04670	COG0789	Transcriptional regulator
AKKM5201_04675	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
AKKM5201_04680	COG0022	dehydrogenase e1 component
AKKM5201_04685	COG0508	dehydrogenase complex catalyzes the overall conversion of
AKKM5201_04715	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
AKKM5201_04720	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
AKKM5201_04720	COG0321	lipoyl(octanoyl) transferase activity
AKKM5201_04725	COG0497	DNA recombination
AKKM5201_04730	COG2217	Heavy metal translocating P-type atpase
AKKM5201_04740	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AKKM5201_04750	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AKKM5201_04755	COG1970	mechanosensitive ion channel activity
AKKM5201_04760	COG1785	Belongs to the alkaline phosphatase family
AKKM5201_04770	COG3525	Glycosyl hydrolase, family 20, catalytic domain
AKKM5201_04775	COG1363	Peptidase, m42
AKKM5201_04785	COG1592	Rubrerythrin
AKKM5201_04795	COG2194	sulfuric ester hydrolase activity
AKKM5201_04830	COG0471	metal ion transport
AKKM5201_04845	COG0490	domain, Protein
AKKM5201_04845	COG2985	domain, Protein
AKKM5201_04895	COG0732	type I restriction modification DNA specificity domain
AKKM5201_04915	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AKKM5201_04920	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AKKM5201_04930	COG3481	metal-dependent phosphohydrolase, HD sub domain
AKKM5201_04940	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
AKKM5201_04945	COG0148	phosphopyruvate hydratase activity
AKKM5201_04960	COG0165	Argininosuccinate lyase
AKKM5201_04965	COG0659	secondary active sulfate transmembrane transporter activity
AKKM5201_04975	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AKKM5201_05025	COG0542	response to heat
AKKM5201_05055	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
AKKM5201_05065	COG0745	RESPONSE REGULATOR receiver
AKKM5201_05070	COG2205	protein histidine kinase activity
AKKM5201_05085	COG3250	beta-galactosidase activity
AKKM5201_05095	COG0084	hydrolase, TatD family'
AKKM5201_05100	COG0791	NLP P60 protein
AKKM5201_05100	COG1388	LysM domain
AKKM5201_05125	COG0592	DNA-directed DNA polymerase activity
AKKM5201_05135	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AKKM5201_05140	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AKKM5201_05140	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AKKM5201_05145	COG0445	tRNA wobble uridine modification
AKKM5201_05155	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AKKM5201_05160	COG0440	acetolactate synthase activity
AKKM5201_05165	COG1643	Atp-dependent helicase
AKKM5201_05175	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AKKM5201_05185	COG0107	imidazoleglycerol-phosphate synthase activity
AKKM5201_05195	COG1733	regulation of RNA biosynthetic process
AKKM5201_05220	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
AKKM5201_05230	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
AKKM5201_05235	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
AKKM5201_05250	COG0535	radical SAM domain protein
AKKM5201_05285	COG0473	3-isopropylmalate dehydrogenase activity
AKKM5201_05300	COG3969	phosphoadenosine phosphosulfate
AKKM5201_05305	COG1475	DNA binding
AKKM5201_05315	COG1525	nuclease
AKKM5201_05325	COG1028	Short-chain dehydrogenase reductase Sdr
AKKM5201_05335	COG1607	acyl-coa hydrolase
AKKM5201_05340	COG0477	Major facilitator Superfamily
AKKM5201_05350	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AKKM5201_05355	COG0588	phosphoglycerate mutase activity
AKKM5201_05395	COG0471	metal ion transport
AKKM5201_05395	COG0490	domain, Protein
AKKM5201_05415	COG2755	lipolytic protein G-D-S-L family
AKKM5201_05415	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
AKKM5201_05435	COG1216	Glycosyl transferase, family 2
AKKM5201_05440	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AKKM5201_05450	COG1216	Glycosyl transferase, family 2
AKKM5201_05450	COG1442	glycosyl transferase family 8
AKKM5201_05460	COG1408	metallophosphoesterase
AKKM5201_05475	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AKKM5201_05480	COG0196	riboflavin kinase activity
AKKM5201_05485	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
AKKM5201_05500	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AKKM5201_05530	COG0546	phosphoglycolate phosphatase activity
AKKM5201_05565	COG0863	Belongs to the N(4) N(6)-methyltransferase family
AKKM5201_05585	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AKKM5201_05585	COG0519	Catalyzes the synthesis of GMP from XMP
AKKM5201_05590	COG0516	GMP reductase activity
AKKM5201_05590	COG0517	IMP dehydrogenase activity
AKKM5201_05595	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AKKM5201_05650	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AKKM5201_05690	COG0191	fructose-bisphosphate aldolase activity
AKKM5201_05695	COG0019	diaminopimelate decarboxylase activity
AKKM5201_05700	COG0628	permease
AKKM5201_05710	COG0531	amino acid
AKKM5201_05715	COG2022	thiamine diphosphate biosynthetic process
AKKM5201_05725	COG4864	UPF0365 protein
AKKM5201_05730	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
AKKM5201_05740	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AKKM5201_05740	COG4651	solute:proton antiporter activity
AKKM5201_05745	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
AKKM5201_05750	COG0217	transcriptional regulatory protein
AKKM5201_05755	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
AKKM5201_05760	COG0602	queuosine metabolic process
AKKM5201_05770	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AKKM5201_05785	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
AKKM5201_05790	COG2855	membrane
AKKM5201_05795	COG0583	DNA-binding transcription factor activity
AKKM5201_05840	COG3118	belongs to the thioredoxin family
AKKM5201_05850	COG0017	Asparaginyl-tRNA synthetase
AKKM5201_05880	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AKKM5201_05890	COG1137	ATPase activity
AKKM5201_05905	COG2877	3-deoxy-8-phosphooctulonate synthase activity
AKKM5201_05920	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
AKKM5201_05930	COG4608	Belongs to the ABC transporter superfamily
AKKM5201_05940	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
AKKM5201_05950	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AKKM5201_05960	COG0066	3-isopropylmalate dehydratase activity
AKKM5201_05965	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AKKM5201_05970	COG0321	lipoyl(octanoyl) transferase activity
AKKM5201_05975	COG0860	N-Acetylmuramoyl-L-alanine amidase
AKKM5201_05980	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
AKKM5201_05990	COG1181	Belongs to the D-alanine--D-alanine ligase family
AKKM5201_05995	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AKKM5201_06000	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AKKM5201_06005	COG0772	Belongs to the SEDS family
AKKM5201_06015	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
AKKM5201_06020	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AKKM5201_06025	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AKKM5201_06030	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AKKM5201_06035	COG0768	penicillin binding
AKKM5201_06045	COG0275	rRNA processing
AKKM5201_06050	COG2001	Belongs to the MraZ family
AKKM5201_06055	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
AKKM5201_06060	COG2860	membrane
AKKM5201_06070	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
AKKM5201_06075	COG0482	sulfurtransferase activity
AKKM5201_06080	COG0463	Glycosyl transferase, family 2
AKKM5201_06080	COG1216	Glycosyl transferase, family 2
AKKM5201_06105	COG0438	transferase activity, transferring glycosyl groups
AKKM5201_06115	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
AKKM5201_06125	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
AKKM5201_06155	COG1028	Short-chain dehydrogenase reductase Sdr
AKKM5201_06170	COG0488	(ABC) transporter
AKKM5201_06180	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
AKKM5201_06190	COG1253	flavin adenine dinucleotide binding
AKKM5201_06195	COG1028	Short-chain dehydrogenase reductase Sdr
AKKM5201_06210	COG1073	alpha beta
AKKM5201_06220	COG0667	Aldo Keto reductase
AKKM5201_06275	COG2267	carboxylic ester hydrolase activity
AKKM5201_06280	COG2095	MarC family integral membrane protein
AKKM5201_06320	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AKKM5201_06325	COG0488	(ABC) transporter
AKKM5201_06330	COG0697	spore germination
AKKM5201_06340	COG0215	cysteine-tRNA ligase activity
AKKM5201_06350	COG3119	arylsulfatase activity
AKKM5201_06360	COG0481	GTPase activity
AKKM5201_06385	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AKKM5201_06390	COG0085	RNA polymerase activity
AKKM5201_06395	COG0222	ribosome binding
AKKM5201_06400	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
AKKM5201_06405	COG0081	regulation of translation
AKKM5201_06410	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
AKKM5201_06415	COG0250	Participates in transcription elongation, termination and antitermination
AKKM5201_06430	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AKKM5201_06440	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
AKKM5201_06450	COG0740	serine-type endopeptidase activity
AKKM5201_06455	COG0544	peptidyl-prolyl cis-trans isomerase activity
AKKM5201_06470	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
AKKM5201_06490	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AKKM5201_06535	COG2226	methyltransferase
AKKM5201_06540	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
AKKM5201_06560	COG0446	pyridine nucleotide-disulphide oxidoreductase
AKKM5201_06560	COG1902	pentaerythritol trinitrate reductase activity
AKKM5201_06570	COG3119	arylsulfatase activity
AKKM5201_06575	COG0514	ATP-dependent DNA helicase (RecQ)
AKKM5201_06595	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
AKKM5201_06600	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AKKM5201_06665	COG1858	cytochrome C peroxidase
AKKM5201_06670	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AKKM5201_06675	COG0590	tRNA wobble adenosine to inosine editing
AKKM5201_06680	COG1940	carbohydrate kinase activity
AKKM5201_06685	COG2217	Heavy metal translocating P-type atpase
AKKM5201_06690	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
AKKM5201_06720	COG1363	Peptidase, m42
AKKM5201_06725	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
AKKM5201_06735	COG0006	proline dipeptidase activity
AKKM5201_06740	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
AKKM5201_06760	COG5002	protein histidine kinase activity
AKKM5201_06765	COG0745	RESPONSE REGULATOR receiver
AKKM5201_06770	COG0129	dihydroxy-acid dehydratase activity
AKKM5201_06840	COG1368	sulfuric ester hydrolase activity
AKKM5201_06875	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AKKM5201_06880	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AKKM5201_06905	COG0534	Mate efflux family protein
AKKM5201_06910	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AKKM5201_06925	COG1876	peptidase activity
AKKM5201_07060	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
AKKM5201_07065	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
AKKM5201_07070	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
AKKM5201_07075	COG2205	protein histidine kinase activity
AKKM5201_07095	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AKKM5201_07115	COG0667	Aldo Keto reductase
AKKM5201_07120	COG0789	Transcriptional regulator
AKKM5201_07170	COG0714	Associated with various cellular activities
AKKM5201_07175	COG2311	Membrane
AKKM5201_07195	COG1090	epimerase
AKKM5201_07210	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
AKKM5201_07215	COG1119	ATPase activity
AKKM5201_07220	COG2186	Transcriptional regulator
AKKM5201_07245	COG0148	phosphopyruvate hydratase activity
AKKM5201_07255	COG1477	protein flavinylation
AKKM5201_07270	COG0227	Belongs to the bacterial ribosomal protein bL28 family
AKKM5201_07280	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
AKKM5201_07300	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
AKKM5201_07310	COG1199	ATP-dependent helicase activity
AKKM5201_07315	COG1122	ATPase activity
AKKM5201_07340	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AKKM5201_07350	COG0359	binds to the 23S rRNA
AKKM5201_07355	COG0138	bifunctional purine biosynthesis protein purh
AKKM5201_07360	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
AKKM5201_07365	COG0736	holo-[acyl-carrier-protein] synthase activity
AKKM5201_07375	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
AKKM5201_07380	COG3409	Peptidoglycan-binding domain 1 protein
AKKM5201_07380	COG5632	N-Acetylmuramoyl-L-alanine amidase
AKKM5201_07385	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AKKM5201_07395	COG0437	4 iron, 4 sulfur cluster binding
AKKM5201_07415	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
AKKM5201_07470	COG0284	orotidine-5'-phosphate decarboxylase activity
AKKM5201_07490	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
AKKM5201_07495	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
AKKM5201_07515	COG2003	Belongs to the UPF0758 family
AKKM5201_07520	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
AKKM5201_07520	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
AKKM5201_07525	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
AKKM5201_07530	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
AKKM5201_07535	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AKKM5201_07540	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
AKKM5201_07545	COG0322	excinuclease ABC activity
AKKM5201_07550	COG0811	peptide transport
AKKM5201_07555	COG0848	biopolymer transport protein
AKKM5201_07565	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
AKKM5201_07570	COG0483	inositol monophosphate 1-phosphatase activity
AKKM5201_07575	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
AKKM5201_07585	COG1482	cell wall glycoprotein biosynthetic process
AKKM5201_07595	COG1757	Na H antiporter
AKKM5201_07600	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AKKM5201_07605	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
AKKM5201_07610	COG0505	Belongs to the CarA family
AKKM5201_07615	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AKKM5201_07625	COG0070	glutamate synthase
AKKM5201_07625	COG0069	glutamate synthase activity
AKKM5201_07625	COG0067	glutamate synthase
AKKM5201_07630	COG0706	membrane insertase activity
AKKM5201_07635	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
AKKM5201_07645	COG0230	Belongs to the bacterial ribosomal protein bL34 family
AKKM5201_07660	COG0657	acetylesterase activity
AKKM5201_07660	COG2755	lipolytic protein G-D-S-L family
AKKM5201_07670	COG0676	glucose-6-phosphate 1-epimerase activity
AKKM5201_07690	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AKKM5201_07710	COG1760	l-serine dehydratase
AKKM5201_07715	COG0492	ferredoxin-NADP+ reductase activity
AKKM5201_07715	COG3118	belongs to the thioredoxin family
AKKM5201_07770	COG1408	metallophosphoesterase
AKKM5201_07780	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
AKKM5201_07785	COG0545	Peptidyl-prolyl cis-trans isomerase
AKKM5201_07800	COG0187	DNA topoisomerase II activity
AKKM5201_07805	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AKKM5201_07815	COG0826	peptidase U32
AKKM5201_07820	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AKKM5201_07840	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AKKM5201_07860	COG2895	sulfate adenylyltransferase (ATP) activity
AKKM5201_07860	COG0529	Catalyzes the synthesis of activated sulfate
AKKM5201_07865	COG0175	sulfate reduction
AKKM5201_07870	COG0175	sulfate reduction
AKKM5201_07890	COG0581	inorganic phosphate transmembrane transporter activity
AKKM5201_07895	COG0573	inorganic phosphate transmembrane transporter activity
AKKM5201_07905	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AKKM5201_07915	COG2017	converts alpha-aldose to the beta-anomer
AKKM5201_07930	COG0612	Peptidase, M16
AKKM5201_07970	COG0233	cytoplasmic translational termination
AKKM5201_07975	COG0528	UMP kinase activity
AKKM5201_07980	COG0668	transmembrane transport
AKKM5201_07985	COG0450	alkyl hydroperoxide reductase
AKKM5201_07990	COG0733	neurotransmitter:sodium symporter activity
AKKM5201_08005	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AKKM5201_08015	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AKKM5201_08020	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AKKM5201_08025	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AKKM5201_08045	COG0842	Transport permease protein
AKKM5201_08050	COG0842	Transport permease protein
AKKM5201_08055	COG1131	(ABC) transporter
AKKM5201_08065	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AKKM5201_08070	COG1183	phosphatidylcholine synthase activity
AKKM5201_08080	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AKKM5201_08090	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
AKKM5201_08095	COG1028	Short-chain dehydrogenase reductase Sdr
AKKM5201_08120	COG0156	8-amino-7-oxononanoate synthase activity
AKKM5201_08145	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
AKKM5201_08150	COG0124	histidyl-tRNA synthetase
AKKM5201_08155	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
AKKM5201_08160	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
AKKM5201_08165	COG0298	carbon dioxide binding
AKKM5201_08195	COG0443	Heat shock 70 kDa protein
AKKM5201_08200	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
AKKM5201_08205	COG0459	protein refolding
AKKM5201_08255	COG0632	four-way junction helicase activity
AKKM5201_08265	COG0126	phosphoglycerate kinase activity
AKKM5201_08275	COG1082	Xylose isomerase domain protein TIM barrel
AKKM5201_08290	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
AKKM5201_08300	COG2271	Major facilitator Superfamily
AKKM5201_08315	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
AKKM5201_08325	COG0037	tRNA processing
AKKM5201_08330	COG0254	rRNA binding
AKKM5201_08365	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
AKKM5201_08370	COG0039	L-malate dehydrogenase activity
AKKM5201_08395	COG0778	Nitroreductase
AKKM5201_08400	COG0564	pseudouridine synthase activity
AKKM5201_08430	COG1126	abc transporter atp-binding protein
AKKM5201_08515	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
AKKM5201_08520	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
AKKM5201_08570	COG1872	DUF167
AKKM5201_08575	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AKKM5201_08580	COG0484	heat shock protein binding
AKKM5201_08585	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AKKM5201_08595	COG5434	Belongs to the glycosyl hydrolase 28 family
AKKM5201_08610	COG0277	FAD linked oxidase domain protein
AKKM5201_08635	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AKKM5201_08640	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
AKKM5201_08650	COG0131	Imidazoleglycerol-phosphate dehydratase
AKKM5201_08655	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
AKKM5201_08660	COG0360	Binds together with S18 to 16S ribosomal RNA
AKKM5201_08665	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
AKKM5201_08680	COG1686	Belongs to the peptidase S11 family
AKKM5201_08685	COG0205	6-phosphofructokinase activity
AKKM5201_08695	COG0428	transporter
AKKM5201_08700	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AKKM5201_08715	COG3977	Valine--pyruvate aminotransferase
AKKM5201_08720	COG1561	YicC-like family, N-terminal region
AKKM5201_08730	COG3273	potassium ion transport
AKKM5201_08730	COG0471	metal ion transport
AKKM5201_08735	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AKKM5201_08750	COG1575	Belongs to the MenA family. Type 1 subfamily
AKKM5201_08780	COG0726	polysaccharide deacetylase
AKKM5201_08785	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AKKM5201_08785	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AKKM5201_08805	COG0202	RNA polymerase activity
AKKM5201_08810	COG0203	ribosomal protein L17
AKKM5201_08815	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
AKKM5201_08825	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AKKM5201_08840	COG2885	chlorophyll binding
AKKM5201_08905	COG0667	Aldo Keto reductase
AKKM5201_08910	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
AKKM5201_08930	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AKKM5201_08935	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AKKM5201_08940	COG0134	indole-3-glycerol-phosphate synthase activity
AKKM5201_08945	COG0135	phosphoribosylanthranilate isomerase activity
AKKM5201_08950	COG0133	tryptophan synthase activity
AKKM5201_08955	COG0159	tryptophan synthase activity
AKKM5201_08970	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AKKM5201_08975	COG0257	Belongs to the bacterial ribosomal protein bL36 family
AKKM5201_08985	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
AKKM5201_09020	COG0561	phosphatase activity
AKKM5201_09025	COG0561	phosphatase activity
AKKM5201_09030	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AKKM5201_09140	COG2314	TM2 domain
AKKM5201_09160	COG0515	serine threonine protein kinase
AKKM5201_09175	COG3177	Filamentation induced by cAMP protein fic
AKKM5201_09205	COG0556	nucleotide-excision repair
AKKM5201_09210	COG0291	Belongs to the bacterial ribosomal protein bL35 family
AKKM5201_09215	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
AKKM5201_09235	COG1074	ATP-dependent DNA helicase activity
AKKM5201_09245	COG0697	spore germination
AKKM5201_09255	COG1002	Type II restriction enzyme, methylase subunits
AKKM5201_09260	COG1061	Type III restriction enzyme res subunit
AKKM5201_09265	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AKKM5201_09270	COG2373	Large extracellular alpha-helical protein
AKKM5201_09275	COG1979	alcohol dehydrogenase
AKKM5201_09290	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AKKM5201_09315	COG0372	Belongs to the citrate synthase family
AKKM5201_09335	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
AKKM5201_09345	COG1187	pseudouridine synthase activity
AKKM5201_09355	COG0105	UTP biosynthetic process
AKKM5201_09360	COG1215	transferase activity, transferring glycosyl groups
AKKM5201_09365	COG0463	Glycosyl transferase, family 2
AKKM5201_09375	COG1459	type II secretion system
AKKM5201_09380	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AKKM5201_09390	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AKKM5201_09405	COG0728	peptidoglycan biosynthetic process
AKKM5201_09410	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
AKKM5201_09410	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
AKKM5201_09425	COG1649	PFAM Uncharacterised BCR, COG1649
AKKM5201_09430	COG1691	(AIR) carboxylase
AKKM5201_09435	COG1606	tRNA processing
AKKM5201_09440	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
AKKM5201_09445	COG0142	geranyltranstransferase activity
AKKM5201_09460	COG2151	metal-sulfur cluster biosynthetic enzyme
AKKM5201_09475	COG1007	ATP synthesis coupled electron transport
AKKM5201_09480	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AKKM5201_09490	COG0713	ATP synthesis coupled electron transport
AKKM5201_09495	COG0839	Belongs to the complex I subunit 6 family
AKKM5201_09505	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
AKKM5201_09510	COG1034	ATP synthesis coupled electron transport
AKKM5201_09515	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
AKKM5201_09520	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
AKKM5201_09525	COG0649	NAD binding
AKKM5201_09530	COG2264	protein methyltransferase activity
AKKM5201_09540	COG0307	riboflavin synthase, alpha
AKKM5201_09550	COG0726	polysaccharide deacetylase
AKKM5201_09565	COG3210	domain, Protein
AKKM5201_09570	COG1640	4-alpha-glucanotransferase
AKKM5201_09580	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AKKM5201_09585	COG1030	water channel activity
AKKM5201_09590	COG0358	DNA primase activity
AKKM5201_09595	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AKKM5201_09600	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
AKKM5201_09615	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AKKM5201_09620	COG0793	Belongs to the peptidase S41A family
AKKM5201_09635	COG1643	Atp-dependent helicase
AKKM5201_09660	COG1450	Type ii and iii secretion system protein
AKKM5201_09675	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AKKM5201_09695	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AKKM5201_09700	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
AKKM5201_09710	COG0268	Binds directly to 16S ribosomal RNA
AKKM5201_09715	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AKKM5201_09720	COG0028	Belongs to the TPP enzyme family
AKKM5201_09735	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AKKM5201_09740	COG0495	leucyl-tRNA aminoacylation
AKKM5201_09745	COG3119	arylsulfatase activity
AKKM5201_09760	COG1166	arginine decarboxylase activity
AKKM5201_09775	COG3250	beta-galactosidase activity
AKKM5201_09780	COG3250	beta-galactosidase activity
AKKM5201_09785	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
AKKM5201_09790	COG3525	Glycosyl hydrolase, family 20, catalytic domain
AKKM5201_09810	COG0205	6-phosphofructokinase activity
AKKM5201_09855	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
AKKM5201_09860	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
AKKM5201_09865	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
AKKM5201_09880	COG4771	TonB-dependent receptor
AKKM5201_09900	COG0402	S-adenosylhomocysteine deaminase activity
AKKM5201_09905	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AKKM5201_09925	COG1294	oxidase, subunit
AKKM5201_09930	COG1271	oxidase subunit
AKKM5201_09940	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AKKM5201_09960	COG1846	Transcriptional regulator
AKKM5201_09990	COG2949	membrane
AKKM5201_10020	COG0514	ATP-dependent DNA helicase (RecQ)
AKKM5201_10035	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
AKKM5201_10040	COG0045	succinate-CoA ligase (ADP-forming) activity
AKKM5201_10115	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AKKM5201_10120	COG2205	protein histidine kinase activity
AKKM5201_10135	COG0113	porphobilinogen synthase activity
AKKM5201_10150	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AKKM5201_10155	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
AKKM5201_10185	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
AKKM5201_10220	COG4106	trans-aconitate 2-methyltransferase activity
AKKM5201_10235	COG3475	LICD family
AKKM5201_10240	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
AKKM5201_10250	COG3475	LICD family
AKKM5201_10270	COG3475	LICD family
AKKM5201_10275	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
AKKM5201_10285	COG2166	iron-sulfur cluster assembly
AKKM5201_10290	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AKKM5201_10300	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AKKM5201_10305	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AKKM5201_10310	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
AKKM5201_10315	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AKKM5201_10320	COG1131	(ABC) transporter
AKKM5201_10335	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
AKKM5201_10350	COG1215	transferase activity, transferring glycosyl groups
AKKM5201_10365	COG1401	restriction endodeoxyribonuclease activity
AKKM5201_10365	COG1401	restriction endodeoxyribonuclease activity
AKKM5201_10380	COG1522	sequence-specific DNA binding
AKKM5201_10385	COG0436	Aminotransferase
AKKM5201_10400	COG0423	glycine-tRNA ligase activity
AKKM5201_10405	COG0656	L-ascorbic acid biosynthetic process
AKKM5201_10435	COG0714	Associated with various cellular activities
AKKM5201_10440	COG0154	amidase activity
AKKM5201_10445	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AKKM5201_10485	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AKKM5201_10490	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AKKM5201_10500	COG2755	lipolytic protein G-D-S-L family
AKKM5201_10500	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
AKKM5201_10520	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
AKKM5201_10530	COG0656	L-ascorbic acid biosynthetic process
AKKM5201_10540	COG0667	Aldo Keto reductase
AKKM5201_10545	COG1408	metallophosphoesterase
AKKM5201_10565	COG2249	NAD(P)H dehydrogenase (quinone) activity
AKKM5201_10570	COG0789	Transcriptional regulator
AKKM5201_10590	COG0534	Mate efflux family protein
AKKM5201_10615	COG1091	dTDP-4-dehydrorhamnose reductase activity
AKKM5201_10630	COG1837	Belongs to the UPF0109 family
AKKM5201_10640	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
AKKM5201_10645	COG0363	glucosamine-6-phosphate deaminase activity
AKKM5201_10660	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
AKKM5201_10680	COG1741	Belongs to the pirin family
AKKM5201_10700	COG1070	Carbohydrate kinase
AKKM5201_10715	COG0738	Major facilitator superfamily
AKKM5201_10730	COG1595	DNA-templated transcription, initiation
AKKM5201_10750	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
AKKM5201_10770	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AKKM5201_10780	COG0232	Belongs to the dGTPase family. Type 2 subfamily
AKKM5201_10785	COG0232	Belongs to the dGTPase family. Type 2 subfamily
AKKM5201_10790	COG2132	Multicopper oxidase
AKKM5201_10810	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AKKM5201_10815	COG4608	Belongs to the ABC transporter superfamily
AKKM5201_10820	COG0444	Belongs to the ABC transporter superfamily
AKKM5201_10825	COG4166	transmembrane transport
AKKM5201_10830	COG4239	(ABC) transporter, permease
AKKM5201_10835	COG0601	transmembrane transport
AKKM5201_10850	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
AKKM5201_10855	COG2759	Belongs to the formate--tetrahydrofolate ligase family
AKKM5201_10860	COG3738	Protein conserved in bacteria
AKKM5201_10875	COG0151	Belongs to the GarS family
AKKM5201_10890	COG0811	peptide transport
AKKM5201_10900	COG0242	peptide deformylase activity
AKKM5201_10940	COG2010	Cytochrome c
AKKM5201_10950	COG3258	Cytochrome c
AKKM5201_10965	COG3274	enterobacterial common antigen metabolic process
AKKM5201_10970	COG0538	isocitrate dehydrogenase activity
AKKM5201_10990	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
AKKM5201_10995	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AKKM5201_11000	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
AKKM5201_11010	COG0668	transmembrane transport
AKKM5201_11015	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AKKM5201_11015	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
AKKM5201_11020	COG0805	protein transport
AKKM5201_11025	COG1968	undecaprenyl-diphosphatase activity
AKKM5201_11045	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
AKKM5201_11055	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AKKM5201_11065	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
AKKM5201_11075	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
AKKM5201_11085	COG1408	metallophosphoesterase
AKKM5201_11110	COG4974	Belongs to the 'phage' integrase family
AKKM5201_11130	COG1454	alcohol dehydrogenase
AKKM5201_11155	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AKKM5201_11155	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
AKKM5201_11160	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
AKKM5201_11200	COG3119	arylsulfatase activity
AKKM5201_11210	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AKKM5201_11220	COG4607	ABC-type enterochelin transport system periplasmic component
AKKM5201_11225	COG4604	ABC transporter, ATP-binding protein
AKKM5201_11230	COG4605	iron ion homeostasis
AKKM5201_11235	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AKKM5201_11270	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AKKM5201_11270	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AKKM5201_11285	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AKKM5201_11290	COG2195	Cleaves the N-terminal amino acid of tripeptides
AKKM5201_11325	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AKKM5201_11350	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AKKM5201_11350	COG0519	Catalyzes the synthesis of GMP from XMP
AKKM5201_11355	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
AKKM5201_11395	COG1410	methionine synthase
AKKM5201_11395	COG0646	methionine synthase
AKKM5201_11400	COG2966	Psort location CytoplasmicMembrane, score
AKKM5201_11405	COG3610	response to peptide
AKKM5201_11415	COG0460	homoserine dehydrogenase
AKKM5201_11420	COG0527	aspartate kinase activity
AKKM5201_11435	COG5522	Integral membrane protein (intg_mem_TP0381)
AKKM5201_11445	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AKKM5201_11450	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AKKM5201_11460	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
AKKM5201_11465	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AKKM5201_11465	COG0574	Belongs to the PEP-utilizing enzyme family
AKKM5201_11475	COG0166	Belongs to the GPI family
AKKM5201_11485	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
AKKM5201_11495	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AKKM5201_11495	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AKKM5201_11530	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AKKM5201_11535	COG2818	Glycosylase
AKKM5201_11555	COG3033	Beta-eliminating lyase
AKKM5201_11570	COG0072	phenylalanine-tRNA ligase activity
AKKM5201_11570	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AKKM5201_11590	COG0326	Molecular chaperone. Has ATPase activity
AKKM5201_11595	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AKKM5201_11610	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
AKKM5201_11625	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AKKM5201_11630	COG1959	2 iron, 2 sulfur cluster binding
AKKM5201_11645	COG0352	thiamine-phosphate diphosphorylase activity
AKKM5201_11650	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
AKKM5201_11665	COG3525	Glycosyl hydrolase, family 20, catalytic domain
AKKM5201_11675	COG1703	isobutyryl-CoA mutase activity
AKKM5201_11695	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
AKKM5201_11705	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AKKM5201_11710	COG0418	dihydroorotase activity
AKKM5201_11725	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AKKM5201_11745	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AKKM5201_11760	COG0534	Mate efflux family protein
AKKM5201_11765	COG0489	protein tyrosine kinase activity
AKKM5201_11780	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AKKM5201_11785	COG0339	signal peptide processing
AKKM5201_11790	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AKKM5201_11800	COG1538	Outer membrane efflux protein
AKKM5201_11815	COG4112	unkown
AKKM5201_11830	COG0038	chloride channel
AKKM5201_11845	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AKKM5201_11855	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AKKM5201_11860	COG0586	Pfam SNARE associated Golgi protein
AKKM5201_11935	COG1012	belongs to the aldehyde dehydrogenase family
AKKM5201_11955	COG0753	catalase activity
AKKM5201_11970	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AKKM5201_11975	COG1592	Rubrerythrin
AKKM5201_11985	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AKKM5201_11995	COG1674	ftsk spoiiie
AKKM5201_12015	COG0489	protein tyrosine kinase activity
AKKM5201_12025	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AKKM5201_12035	COG0438	transferase activity, transferring glycosyl groups
AKKM5201_12045	COG0438	transferase activity, transferring glycosyl groups
AKKM5201_12075	COG0438	transferase activity, transferring glycosyl groups
AKKM5201_12085	COG0110	maltose O-acetyltransferase activity
AKKM5201_12095	COG1216	Glycosyl transferase, family 2
AKKM5201_12100	COG1216	Glycosyl transferase, family 2
AKKM5201_12130	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
AKKM5201_12130	COG2755	lipolytic protein G-D-S-L family
AKKM5201_12150	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
AKKM5201_12160	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AKKM5201_12165	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
AKKM5201_12170	COG0280	phosphate acetyltransferase
AKKM5201_12170	COG0281	malic enzyme
AKKM5201_12205	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AKKM5201_12240	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
AKKM5201_12245	COG1063	alcohol dehydrogenase
AKKM5201_12260	COG0714	Associated with various cellular activities
AKKM5201_12270	COG0193	aminoacyl-tRNA hydrolase activity
AKKM5201_12275	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AKKM5201_12290	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AKKM5201_12310	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
AKKM5201_12325	COG0375	protein maturation
AKKM5201_12350	COG0778	Nitroreductase
AKKM5201_12355	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AKKM5201_12375	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AKKM5201_12375	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AKKM5201_12385	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
AKKM5201_12385	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
AKKM5201_12405	COG3525	Glycosyl hydrolase, family 20, catalytic domain
AKKM5201_12410	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
AKKM5201_12415	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
AKKM5201_12425	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AKKM5201_12430	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AKKM5201_12445	COG0318	PFAM AMP-dependent synthetase and ligase
AKKM5201_12475	COG0339	signal peptide processing
AKKM5201_12485	COG0018	arginyl-trna synthetase
AKKM5201_12520	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AKKM5201_12525	COG0653	protein targeting
AKKM5201_12540	COG0494	nUDIX hydrolase