locus-tag	class	description
C1O60_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
C1O60_00010	COG1131	(ABC) transporter
C1O60_00030	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
C1O60_00035	COG0564	pseudouridine synthase activity
C1O60_00050	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
C1O60_00055	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
C1O60_00065	COG0513	Belongs to the DEAD box helicase family
C1O60_00085	COG0673	inositol 2-dehydrogenase activity
C1O60_00100	COG2814	Major facilitator Superfamily
C1O60_00120	COG1971	Probably functions as a manganese efflux pump
C1O60_00150	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C1O60_00175	COG0442	prolyl-tRNA aminoacylation
C1O60_00220	COG0531	amino acid
C1O60_00225	COG2066	Belongs to the glutaminase family
C1O60_00240	COG1115	amino acid carrier protein
C1O60_00250	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
C1O60_00255	COG2890	protein-(glutamine-N5) methyltransferase activity
C1O60_00260	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
C1O60_00265	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
C1O60_00285	COG2226	methyltransferase
C1O60_00290	COG0534	Mate efflux family protein
C1O60_00335	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C1O60_00340	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
C1O60_00345	COG3525	Glycosyl hydrolase, family 20, catalytic domain
C1O60_00360	COG1121	(ABC) transporter
C1O60_00370	COG3880	PFAM UvrB UvrC protein
C1O60_00375	COG3869	Catalyzes the specific phosphorylation of arginine residues in
C1O60_00380	COG3869	Catalyzes the specific phosphorylation of arginine residues in
C1O60_00385	COG0542	response to heat
C1O60_00395	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C1O60_00400	COG0179	Fumarylacetoacetate (FAA) hydrolase
C1O60_00405	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C1O60_00420	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
C1O60_00420	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
C1O60_00430	COG0180	Tryptophanyl-tRNA synthetase
C1O60_00440	COG1692	metallophosphoesterase
C1O60_00450	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
C1O60_00515	COG0515	serine threonine protein kinase
C1O60_00615	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C1O60_00625	COG2816	NAD+ diphosphatase activity
C1O60_00635	COG0156	8-amino-7-oxononanoate synthase activity
C1O60_00645	COG1192	Involved in chromosome partitioning
C1O60_00650	COG3266	domain, Protein
C1O60_00650	COG0515	serine threonine protein kinase
C1O60_00690	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
C1O60_00705	COG3189	MarR family transcriptional regulator
C1O60_00715	COG0181	hydroxymethylbilane synthase activity
C1O60_00720	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
C1O60_00730	COG1469	GTP cyclohydrolase I activity
C1O60_00735	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
C1O60_00740	COG0267	Belongs to the bacterial ribosomal protein bL33 family
C1O60_00745	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
C1O60_00750	COG1940	carbohydrate kinase activity
C1O60_00765	COG0494	nUDIX hydrolase
C1O60_00770	COG1566	PFAM secretion protein HlyD family protein
C1O60_00775	COG0577	efflux transmembrane transporter activity
C1O60_00775	COG1136	(ABC) transporter
C1O60_00780	COG1136	(ABC) transporter
C1O60_00780	COG0577	efflux transmembrane transporter activity
C1O60_00785	COG1538	Outer membrane efflux protein
C1O60_00800	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C1O60_00845	COG1720	tRNA m6t6A37 methyltransferase activity
C1O60_00850	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C1O60_00855	COG0540	Belongs to the ATCase OTCase family
C1O60_00860	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
C1O60_00875	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
C1O60_00880	COG2957	Belongs to the agmatine deiminase family
C1O60_00890	COG0750	zinc metalloprotease
C1O60_00900	COG3119	arylsulfatase activity
C1O60_00910	COG1918	ferrous iron import across plasma membrane
C1O60_00910	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
C1O60_00975	COG1475	DNA binding
C1O60_01010	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
C1O60_01030	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C1O60_01035	COG0601	transmembrane transport
C1O60_01095	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C1O60_01100	COG1132	(ABC) transporter
C1O60_01105	COG1132	(ABC) transporter
C1O60_01120	COG1127	ABC transporter
C1O60_01125	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
C1O60_01160	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C1O60_01175	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
C1O60_01180	COG0504	CTP synthase activity
C1O60_01185	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C1O60_01215	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C1O60_01225	COG1322	Protein conserved in bacteria
C1O60_01230	COG0546	phosphoglycolate phosphatase activity
C1O60_01235	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C1O60_01245	COG4591	ABC-type transport system involved in lipoprotein release permease component
C1O60_01245	COG4591	ABC-type transport system involved in lipoprotein release permease component
C1O60_01250	COG3209	COG3209 Rhs family protein
C1O60_01295	COG2234	aminopeptidase activity
C1O60_01305	COG2755	lipolytic protein G-D-S-L family
C1O60_01305	COG0657	acetylesterase activity
C1O60_01310	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
C1O60_01330	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
C1O60_01355	COG0335	large ribosomal subunit rRNA binding
C1O60_01365	COG0346	lactoylglutathione lyase activity
C1O60_01380	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
C1O60_01385	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
C1O60_01395	COG0427	acetyl-CoA hydrolase
C1O60_01410	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
C1O60_01420	COG0205	6-phosphofructokinase activity
C1O60_01430	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C1O60_01435	COG0028	Belongs to the TPP enzyme family
C1O60_01455	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
C1O60_01470	COG0471	metal ion transport
C1O60_01480	COG0351	phosphomethylpyrimidine kinase
C1O60_01545	COG0242	peptide deformylase activity
C1O60_01550	COG1063	alcohol dehydrogenase
C1O60_01560	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C1O60_01565	COG1393	Belongs to the ArsC family
C1O60_01570	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
C1O60_01590	COG1187	pseudouridine synthase activity
C1O60_01600	COG0336	Belongs to the RNA methyltransferase TrmD family
C1O60_01605	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
C1O60_01615	COG0539	negative regulation of cytoplasmic translation
C1O60_01665	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
C1O60_01670	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
C1O60_01675	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
C1O60_01680	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C1O60_01720	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C1O60_01745	COG0662	Cupin 2, conserved barrel domain protein
C1O60_01745	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
C1O60_01755	COG0416	fatty acid biosynthetic process
C1O60_01760	COG0333	Belongs to the bacterial ribosomal protein bL32 family
C1O60_01770	COG0537	adenosine 5'-monophosphoramidase activity
C1O60_01775	COG0009	L-threonylcarbamoyladenylate synthase
C1O60_01780	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
C1O60_01785	COG0228	four-way junction DNA binding
C1O60_01810	COG1862	Preprotein translocase
C1O60_01815	COG0343	queuine tRNA-ribosyltransferase activity
C1O60_01820	COG0220	tRNA (guanine-N7-)-methyltransferase activity
C1O60_01830	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
C1O60_01835	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
C1O60_01840	COG0776	regulation of translation
C1O60_01875	COG0811	peptide transport
C1O60_01895	COG3250	beta-galactosidase activity
C1O60_01900	COG0525	valine-tRNA ligase activity
C1O60_01910	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
C1O60_01915	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
C1O60_01920	COG0255	Belongs to the universal ribosomal protein uL29 family
C1O60_01925	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
C1O60_01930	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
C1O60_01935	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
C1O60_01945	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
C1O60_01950	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
C1O60_01955	COG0089	rRNA binding
C1O60_01960	COG0088	Forms part of the polypeptide exit tunnel
C1O60_01965	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
C1O60_01970	COG0051	transcription antitermination factor activity, RNA binding
C1O60_01975	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
C1O60_01980	COG0049	tRNA binding
C1O60_01985	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
C1O60_01995	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
C1O60_02005	COG3852	Histidine kinase
C1O60_02010	COG2204	response regulator
C1O60_02020	COG1722	exodeoxyribonuclease VII activity
C1O60_02025	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
C1O60_02040	COG0795	lipopolysaccharide-transporting ATPase activity
C1O60_02045	COG1160	GTP binding
C1O60_02050	COG0444	Belongs to the ABC transporter superfamily
C1O60_02070	COG0577	efflux transmembrane transporter activity
C1O60_02070	COG1136	(ABC) transporter
C1O60_02080	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
C1O60_02125	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
C1O60_02135	COG0799	negative regulation of ribosome biogenesis
C1O60_02140	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C1O60_02195	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
C1O60_02210	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
C1O60_02220	COG4221	oxidoreductase activity
C1O60_02250	COG0038	chloride channel
C1O60_02260	COG3525	Glycosyl hydrolase, family 20, catalytic domain
C1O60_02275	COG0076	glutamate decarboxylase activity
C1O60_02290	COG0167	dihydroorotate dehydrogenase activity
C1O60_02295	COG0352	thiamine-phosphate diphosphorylase activity
C1O60_02315	COG1253	flavin adenine dinucleotide binding
C1O60_02320	COG1253	flavin adenine dinucleotide binding
C1O60_02325	COG1185	polyribonucleotide nucleotidyltransferase activity
C1O60_02330	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
C1O60_02360	COG0101	tRNA pseudouridine synthase activity
C1O60_02365	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
C1O60_02385	COG4968	Prepilin-type N-terminal cleavage methylation domain
C1O60_02400	COG3525	Glycosyl hydrolase, family 20, catalytic domain
C1O60_02405	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
C1O60_02420	COG1136	(ABC) transporter
C1O60_02425	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
C1O60_02435	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C1O60_02445	COG1116	anion transmembrane transporter activity
C1O60_02460	COG3525	Glycosyl hydrolase, family 20, catalytic domain
C1O60_02470	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
C1O60_02475	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
C1O60_02490	COG0828	Belongs to the bacterial ribosomal protein bS21 family
C1O60_02495	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
C1O60_02510	COG2814	Major facilitator Superfamily
C1O60_02520	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C1O60_02525	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C1O60_02525	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C1O60_02530	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
C1O60_02535	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C1O60_02540	COG0552	protein localization to endoplasmic reticulum
C1O60_02545	COG0820	rRNA (adenine-C2-)-methyltransferase activity
C1O60_02565	COG1546	Belongs to the CinA family
C1O60_02565	COG1058	Belongs to the CinA family
C1O60_02575	COG0456	acetyltransferase
C1O60_02600	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
C1O60_02605	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
C1O60_02610	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
C1O60_02615	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
C1O60_02630	COG0758	DNA mediated transformation
C1O60_02635	COG1686	Belongs to the peptidase S11 family
C1O60_02640	COG0012	GTP binding
C1O60_02655	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C1O60_02655	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C1O60_02670	COG3119	arylsulfatase activity
C1O60_02700	COG2259	Doxx family
C1O60_02705	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
C1O60_02735	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
C1O60_02755	COG2326	polyphosphate kinase activity
C1O60_02760	COG1349	DNA-binding transcription factor activity
C1O60_02775	COG1104	cysteine desulfurase activity
C1O60_02785	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
C1O60_02790	COG1162	GTPase activity
C1O60_02805	COG0742	ribosomal rna small subunit methyltransferase
C1O60_02820	COG2326	polyphosphate kinase activity
C1O60_02830	COG5434	Belongs to the glycosyl hydrolase 28 family
C1O60_02840	COG1073	alpha beta
C1O60_02845	COG0802	atpase or kinase
C1O60_02855	COG0211	Belongs to the bacterial ribosomal protein bL27 family
C1O60_02860	COG0735	belongs to the Fur family
C1O60_02865	COG0396	ATPase activity
C1O60_02870	COG0719	Fe-S assembly protein
C1O60_02875	COG0719	Fe-S assembly protein
C1O60_02940	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C1O60_02960	COG0355	proton-transporting ATP synthase activity, rotational mechanism
C1O60_02965	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
C1O60_02970	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
C1O60_02975	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
C1O60_02980	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
C1O60_02985	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
C1O60_02995	COG0356	it plays a direct role in the translocation of protons across the membrane
C1O60_03050	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
C1O60_03085	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
C1O60_03090	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
C1O60_03095	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
C1O60_03105	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
C1O60_03115	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
C1O60_03120	COG0047	phosphoribosylformylglycinamidine synthase activity
C1O60_03130	COG1363	Peptidase, m42
C1O60_03145	COG1077	Cell shape determining protein MreB Mrl
C1O60_03150	COG1530	ribonuclease E activity
C1O60_03175	COG0848	biopolymer transport protein
C1O60_03190	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
C1O60_03215	COG0134	indole-3-glycerol-phosphate synthase activity
C1O60_03220	COG0792	nuclease activity
C1O60_03230	COG1253	flavin adenine dinucleotide binding
C1O60_03240	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
C1O60_03250	COG0137	argininosuccinate synthase activity
C1O60_03265	COG0149	triose-phosphate isomerase activity
C1O60_03300	COG1040	competence protein
C1O60_03310	COG3956	TIGRFAM MazG family protein
C1O60_03335	COG1663	tetraacyldisaccharide 4'-kinase activity
C1O60_03345	COG0612	Peptidase, M16
C1O60_03365	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
C1O60_03370	COG0583	DNA-binding transcription factor activity
C1O60_03400	COG0673	inositol 2-dehydrogenase activity
C1O60_03405	COG3034	peptidoglycan biosynthetic process
C1O60_03425	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C1O60_03430	COG0424	maF-like protein
C1O60_03435	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
C1O60_03465	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
C1O60_03475	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
C1O60_03485	COG0571	ribonuclease III activity
C1O60_03500	COG0708	Exodeoxyribonuclease III
C1O60_03505	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
C1O60_03520	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
C1O60_03540	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
C1O60_03560	COG2226	methyltransferase
C1O60_03570	COG2076	Multidrug Resistance protein
C1O60_03610	COG2255	four-way junction helicase activity
C1O60_03615	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C1O60_03620	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
C1O60_03625	COG1215	transferase activity, transferring glycosyl groups
C1O60_03630	COG0463	Glycosyl transferase, family 2
C1O60_03630	COG1216	Glycosyl transferase, family 2
C1O60_03655	COG0438	transferase activity, transferring glycosyl groups
C1O60_03665	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
C1O60_03675	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
C1O60_03685	COG0482	sulfurtransferase activity
C1O60_03690	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
C1O60_03700	COG4974	Belongs to the 'phage' integrase family
C1O60_03720	COG1910	domain protein
C1O60_03790	COG2860	membrane
C1O60_03795	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
C1O60_03800	COG2001	Belongs to the MraZ family
C1O60_03805	COG0275	rRNA processing
C1O60_03815	COG0768	penicillin binding
C1O60_03820	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
C1O60_03825	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
C1O60_03830	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C1O60_03835	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
C1O60_03845	COG0772	Belongs to the SEDS family
C1O60_03850	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
C1O60_03855	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C1O60_03860	COG1181	Belongs to the D-alanine--D-alanine ligase family
C1O60_03870	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
C1O60_03875	COG0860	N-Acetylmuramoyl-L-alanine amidase
C1O60_03880	COG0321	lipoyl(octanoyl) transferase activity
C1O60_03885	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
C1O60_03890	COG0066	3-isopropylmalate dehydratase activity
C1O60_03900	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C1O60_03915	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
C1O60_03925	COG4608	Belongs to the ABC transporter superfamily
C1O60_03935	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
C1O60_03950	COG2877	3-deoxy-8-phosphooctulonate synthase activity
C1O60_03965	COG1137	ATPase activity
C1O60_03975	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C1O60_03990	COG1733	regulation of RNA biosynthetic process
C1O60_04000	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
C1O60_04040	COG0017	Asparaginyl-tRNA synthetase
C1O60_04050	COG3118	belongs to the thioredoxin family
C1O60_04095	COG0583	DNA-binding transcription factor activity
C1O60_04100	COG2855	membrane
C1O60_04105	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
C1O60_04120	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C1O60_04130	COG0602	queuosine metabolic process
C1O60_04135	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
C1O60_04140	COG0217	transcriptional regulatory protein
C1O60_04145	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
C1O60_04150	COG4651	solute:proton antiporter activity
C1O60_04150	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
C1O60_04160	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
C1O60_04165	COG4864	UPF0365 protein
C1O60_04175	COG2022	thiamine diphosphate biosynthetic process
C1O60_04180	COG0531	amino acid
C1O60_04195	COG0019	diaminopimelate decarboxylase activity
C1O60_04200	COG0191	fructose-bisphosphate aldolase activity
C1O60_04240	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
C1O60_04275	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C1O60_04280	COG0516	GMP reductase activity
C1O60_04280	COG0517	IMP dehydrogenase activity
C1O60_04290	COG1196	nuclear chromosome segregation
C1O60_04300	COG0546	phosphoglycolate phosphatase activity
C1O60_04325	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
C1O60_04340	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
C1O60_04345	COG0196	riboflavin kinase activity
C1O60_04350	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
C1O60_04365	COG1408	metallophosphoesterase
C1O60_04375	COG1442	glycosyl transferase family 8
C1O60_04375	COG1216	Glycosyl transferase, family 2
C1O60_04385	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C1O60_04390	COG1216	Glycosyl transferase, family 2
C1O60_04410	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
C1O60_04410	COG2755	lipolytic protein G-D-S-L family
C1O60_04425	COG0490	domain, Protein
C1O60_04425	COG0471	metal ion transport
C1O60_04465	COG0588	phosphoglycerate mutase activity
C1O60_04470	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C1O60_04480	COG0477	Major facilitator Superfamily
C1O60_04485	COG1607	acyl-coa hydrolase
C1O60_04495	COG1028	Short-chain dehydrogenase reductase Sdr
C1O60_04505	COG1525	nuclease
C1O60_04520	COG1475	DNA binding
C1O60_04525	COG3969	phosphoadenosine phosphosulfate
C1O60_04540	COG0473	3-isopropylmalate dehydrogenase activity
C1O60_04575	COG0535	radical SAM domain protein
C1O60_04590	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
C1O60_04595	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
C1O60_04605	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
C1O60_04625	COG1733	regulation of RNA biosynthetic process
C1O60_04635	COG0107	imidazoleglycerol-phosphate synthase activity
C1O60_04645	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C1O60_04655	COG1643	Atp-dependent helicase
C1O60_04660	COG0440	acetolactate synthase activity
C1O60_04665	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C1O60_04675	COG0445	tRNA wobble uridine modification
C1O60_04680	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C1O60_04680	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C1O60_04685	COG0592	DNA-directed DNA polymerase activity
C1O60_04710	COG1388	LysM domain
C1O60_04710	COG0791	NLP P60 protein
C1O60_04715	COG0084	hydrolase, TatD family'
C1O60_04725	COG3250	beta-galactosidase activity
C1O60_04740	COG2205	protein histidine kinase activity
C1O60_04745	COG0745	RESPONSE REGULATOR receiver
C1O60_04755	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
C1O60_04780	COG0542	response to heat
C1O60_04830	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
C1O60_04840	COG0659	secondary active sulfate transmembrane transporter activity
C1O60_04845	COG0165	Argininosuccinate lyase
C1O60_04865	COG0148	phosphopyruvate hydratase activity
C1O60_04870	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
C1O60_04885	COG3481	metal-dependent phosphohydrolase, HD sub domain
C1O60_04895	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C1O60_04900	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C1O60_04965	COG2985	domain, Protein
C1O60_04965	COG0490	domain, Protein
C1O60_04980	COG0471	metal ion transport
C1O60_05005	COG2194	sulfuric ester hydrolase activity
C1O60_05010	COG1592	Rubrerythrin
C1O60_05020	COG1363	Peptidase, m42
C1O60_05025	COG3525	Glycosyl hydrolase, family 20, catalytic domain
C1O60_05035	COG1785	Belongs to the alkaline phosphatase family
C1O60_05040	COG1970	mechanosensitive ion channel activity
C1O60_05045	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C1O60_05055	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
C1O60_05065	COG2217	Heavy metal translocating P-type atpase
C1O60_05070	COG0497	DNA recombination
C1O60_05075	COG0321	lipoyl(octanoyl) transferase activity
C1O60_05075	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
C1O60_05080	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
C1O60_05110	COG0508	dehydrogenase complex catalyzes the overall conversion of
C1O60_05115	COG0022	dehydrogenase e1 component
C1O60_05120	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
C1O60_05135	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C1O60_05140	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C1O60_05150	COG3210	domain, Protein
C1O60_05200	COG5632	N-Acetylmuramoyl-L-alanine amidase
C1O60_05200	COG3409	Peptidoglycan-binding domain 1 protein
C1O60_05205	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
C1O60_05235	COG1690	Belongs to the RtcB family
C1O60_05245	COG2814	Major facilitator Superfamily
C1O60_05255	COG2096	Adenosyltransferase
C1O60_05265	COG0557	exoribonuclease II activity
C1O60_05290	COG0826	peptidase U32
C1O60_05295	COG0285	dihydrofolate synthase activity
C1O60_05310	COG0673	inositol 2-dehydrogenase activity
C1O60_05315	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C1O60_05320	COG0737	Belongs to the 5'-nucleotidase family
C1O60_05330	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
C1O60_05335	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
C1O60_05345	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
C1O60_05350	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
C1O60_05355	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
C1O60_05360	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
C1O60_05365	COG0200	Binds to the 23S rRNA
C1O60_05370	COG0201	protein transport
C1O60_05375	COG0563	adenylate kinase activity
C1O60_05380	COG0024	Methionine aminopeptidase
C1O60_05395	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
C1O60_05400	COG1442	glycosyl transferase family 8
C1O60_05415	COG1216	Glycosyl transferase, family 2
C1O60_05425	COG1216	Glycosyl transferase, family 2
C1O60_05440	COG1216	Glycosyl transferase, family 2
C1O60_05445	COG0693	protein deglycase activity
C1O60_05450	COG0508	dehydrogenase complex catalyzes the overall conversion of
C1O60_05455	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
C1O60_05460	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
C1O60_05470	COG1966	Carbon starvation protein
C1O60_05480	COG3119	arylsulfatase activity
C1O60_05485	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
C1O60_05490	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
C1O60_05495	COG0195	Participates in both transcription termination and antitermination
C1O60_05500	COG0708	Exodeoxyribonuclease III
C1O60_05505	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
C1O60_05510	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
C1O60_05515	COG2006	4fe-4S ferredoxin, iron-sulfur binding domain protein
C1O60_05525	COG1716	ATPase activity
C1O60_05525	COG0842	Transport permease protein
C1O60_05525	COG1131	(ABC) transporter
C1O60_05545	COG0724	RNA recognition motif
C1O60_05550	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
C1O60_05570	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
C1O60_05580	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
C1O60_05585	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C1O60_05600	COG1490	D-aminoacyl-tRNA deacylase activity
C1O60_05610	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
C1O60_05615	COG1053	succinate dehydrogenase
C1O60_05665	COG1028	Short-chain dehydrogenase reductase Sdr
C1O60_05675	COG0488	(ABC) transporter
C1O60_05685	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
C1O60_05695	COG1253	flavin adenine dinucleotide binding
C1O60_05700	COG1028	Short-chain dehydrogenase reductase Sdr
C1O60_05710	COG1073	alpha beta
C1O60_05720	COG0667	Aldo Keto reductase
C1O60_05780	COG2267	carboxylic ester hydrolase activity
C1O60_05785	COG2095	MarC family integral membrane protein
C1O60_05815	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
C1O60_05820	COG0488	(ABC) transporter
C1O60_05900	COG3119	arylsulfatase activity
C1O60_05910	COG0481	GTPase activity
C1O60_05930	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
C1O60_05935	COG0085	RNA polymerase activity
C1O60_05940	COG0222	ribosome binding
C1O60_05945	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
C1O60_05950	COG0081	regulation of translation
C1O60_05955	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
C1O60_05960	COG0250	Participates in transcription elongation, termination and antitermination
C1O60_05975	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
C1O60_05985	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
C1O60_05995	COG0740	serine-type endopeptidase activity
C1O60_06000	COG0544	peptidyl-prolyl cis-trans isomerase activity
C1O60_06015	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
C1O60_06035	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C1O60_06080	COG2226	methyltransferase
C1O60_06085	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
C1O60_06090	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
C1O60_06110	COG1902	pentaerythritol trinitrate reductase activity
C1O60_06110	COG0446	pyridine nucleotide-disulphide oxidoreductase
C1O60_06120	COG3119	arylsulfatase activity
C1O60_06125	COG0514	ATP-dependent DNA helicase (RecQ)
C1O60_06145	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
C1O60_06150	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C1O60_06200	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
C1O60_06215	COG1858	cytochrome C peroxidase
C1O60_06220	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
C1O60_06225	COG0590	tRNA wobble adenosine to inosine editing
C1O60_06230	COG1940	carbohydrate kinase activity
C1O60_06235	COG2217	Heavy metal translocating P-type atpase
C1O60_06240	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
C1O60_06270	COG1363	Peptidase, m42
C1O60_06275	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
C1O60_06285	COG0006	proline dipeptidase activity
C1O60_06290	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
C1O60_06315	COG5002	protein histidine kinase activity
C1O60_06320	COG0745	RESPONSE REGULATOR receiver
C1O60_06325	COG0129	dihydroxy-acid dehydratase activity
C1O60_06350	COG1368	sulfuric ester hydrolase activity
C1O60_06385	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
C1O60_06390	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
C1O60_06410	COG0534	Mate efflux family protein
C1O60_06415	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C1O60_06430	COG1876	peptidase activity
C1O60_06555	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
C1O60_06560	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
C1O60_06565	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
C1O60_06570	COG2205	protein histidine kinase activity
C1O60_06590	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C1O60_06610	COG0789	Transcriptional regulator
C1O60_06660	COG0714	Associated with various cellular activities
C1O60_06665	COG2311	Membrane
C1O60_06685	COG1090	epimerase
C1O60_06700	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
C1O60_06705	COG1119	ATPase activity
C1O60_06710	COG2186	Transcriptional regulator
C1O60_06740	COG0148	phosphopyruvate hydratase activity
C1O60_06755	COG1477	protein flavinylation
C1O60_06770	COG0227	Belongs to the bacterial ribosomal protein bL28 family
C1O60_06785	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
C1O60_06805	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
C1O60_06815	COG1199	ATP-dependent helicase activity
C1O60_06820	COG1122	ATPase activity
C1O60_06845	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
C1O60_06855	COG0359	binds to the 23S rRNA
C1O60_06860	COG0138	bifunctional purine biosynthesis protein purh
C1O60_06865	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
C1O60_06870	COG0736	holo-[acyl-carrier-protein] synthase activity
C1O60_06880	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
C1O60_06885	COG5632	N-Acetylmuramoyl-L-alanine amidase
C1O60_06885	COG3409	Peptidoglycan-binding domain 1 protein
C1O60_06890	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
C1O60_06900	COG0437	4 iron, 4 sulfur cluster binding
C1O60_06920	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
C1O60_06975	COG0284	orotidine-5'-phosphate decarboxylase activity
C1O60_06995	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
C1O60_07000	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
C1O60_07020	COG2003	Belongs to the UPF0758 family
C1O60_07025	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
C1O60_07025	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
C1O60_07030	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
C1O60_07035	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
C1O60_07040	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
C1O60_07045	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
C1O60_07050	COG0322	excinuclease ABC activity
C1O60_07055	COG0811	peptide transport
C1O60_07060	COG0848	biopolymer transport protein
C1O60_07070	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
C1O60_07075	COG0483	inositol monophosphate 1-phosphatase activity
C1O60_07080	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
C1O60_07090	COG1482	cell wall glycoprotein biosynthetic process
C1O60_07100	COG1757	Na H antiporter
C1O60_07105	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C1O60_07110	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
C1O60_07115	COG0505	Belongs to the CarA family
C1O60_07120	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
C1O60_07130	COG0070	glutamate synthase
C1O60_07130	COG0069	glutamate synthase activity
C1O60_07130	COG0067	glutamate synthase
C1O60_07135	COG0706	membrane insertase activity
C1O60_07140	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
C1O60_07150	COG0230	Belongs to the bacterial ribosomal protein bL34 family
C1O60_07165	COG2755	lipolytic protein G-D-S-L family
C1O60_07165	COG0657	acetylesterase activity
C1O60_07175	COG0676	glucose-6-phosphate 1-epimerase activity
C1O60_07195	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
C1O60_07210	COG1760	l-serine dehydratase
C1O60_07215	COG3118	belongs to the thioredoxin family
C1O60_07215	COG0492	ferredoxin-NADP+ reductase activity
C1O60_07270	COG1408	metallophosphoesterase
C1O60_07280	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
C1O60_07285	COG0545	Peptidyl-prolyl cis-trans isomerase
C1O60_07300	COG0187	DNA topoisomerase II activity
C1O60_07305	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
C1O60_07315	COG0826	peptidase U32
C1O60_07320	COG1262	PFAM Formylglycine-generating sulfatase enzyme
C1O60_07340	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C1O60_07360	COG0529	Catalyzes the synthesis of activated sulfate
C1O60_07360	COG2895	sulfate adenylyltransferase (ATP) activity
C1O60_07365	COG0175	sulfate reduction
C1O60_07370	COG0175	sulfate reduction
C1O60_07390	COG0581	inorganic phosphate transmembrane transporter activity
C1O60_07395	COG0573	inorganic phosphate transmembrane transporter activity
C1O60_07405	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
C1O60_07415	COG2017	converts alpha-aldose to the beta-anomer
C1O60_07430	COG0612	Peptidase, M16
C1O60_07480	COG0233	cytoplasmic translational termination
C1O60_07485	COG0528	UMP kinase activity
C1O60_07490	COG0668	transmembrane transport
C1O60_07500	COG0450	alkyl hydroperoxide reductase
C1O60_07505	COG0733	neurotransmitter:sodium symporter activity
C1O60_07530	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C1O60_07535	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C1O60_07540	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C1O60_07560	COG0842	Transport permease protein
C1O60_07565	COG0842	Transport permease protein
C1O60_07570	COG1131	(ABC) transporter
C1O60_07580	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
C1O60_07585	COG1183	phosphatidylcholine synthase activity
C1O60_07595	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
C1O60_07605	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
C1O60_07610	COG1028	Short-chain dehydrogenase reductase Sdr
C1O60_07630	COG0156	8-amino-7-oxononanoate synthase activity
C1O60_07655	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
C1O60_07660	COG0124	histidyl-tRNA synthetase
C1O60_07665	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
C1O60_07670	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
C1O60_07675	COG0298	carbon dioxide binding
C1O60_07705	COG0443	Heat shock 70 kDa protein
C1O60_07710	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
C1O60_07715	COG0459	protein refolding
C1O60_07765	COG0632	four-way junction helicase activity
C1O60_07775	COG0126	phosphoglycerate kinase activity
C1O60_07785	COG1082	Xylose isomerase domain protein TIM barrel
C1O60_07795	COG0863	Belongs to the N(4) N(6)-methyltransferase family
C1O60_07805	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
C1O60_07815	COG2271	Major facilitator Superfamily
C1O60_07830	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
C1O60_07840	COG0037	tRNA processing
C1O60_07845	COG0254	rRNA binding
C1O60_07880	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
C1O60_07885	COG0039	L-malate dehydrogenase activity
C1O60_07910	COG0778	Nitroreductase
C1O60_07915	COG0564	pseudouridine synthase activity
C1O60_07940	COG1126	abc transporter atp-binding protein
C1O60_07945	COG0765	amino acid transport
C1O60_07955	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
C1O60_07960	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
C1O60_08010	COG1872	DUF167
C1O60_08015	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
C1O60_08020	COG0484	heat shock protein binding
C1O60_08025	COG1385	rRNA (uridine-N3-)-methyltransferase activity
C1O60_08035	COG5434	Belongs to the glycosyl hydrolase 28 family
C1O60_08055	COG0277	FAD linked oxidase domain protein
C1O60_08085	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
C1O60_08100	COG0131	Imidazoleglycerol-phosphate dehydratase
C1O60_08105	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
C1O60_08110	COG0360	Binds together with S18 to 16S ribosomal RNA
C1O60_08115	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
C1O60_08130	COG1686	Belongs to the peptidase S11 family
C1O60_08135	COG0205	6-phosphofructokinase activity
C1O60_08145	COG0428	transporter
C1O60_08150	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C1O60_08160	COG3977	Valine--pyruvate aminotransferase
C1O60_08165	COG1561	YicC-like family, N-terminal region
C1O60_08175	COG3273	potassium ion transport
C1O60_08175	COG0471	metal ion transport
C1O60_08180	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C1O60_08195	COG1575	Belongs to the MenA family. Type 1 subfamily
C1O60_08230	COG0726	polysaccharide deacetylase
C1O60_08235	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C1O60_08235	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C1O60_08265	COG0202	RNA polymerase activity
C1O60_08270	COG0203	ribosomal protein L17
C1O60_08275	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
C1O60_08280	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C1O60_08295	COG2885	chlorophyll binding
C1O60_08355	COG0667	Aldo Keto reductase
C1O60_08360	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
C1O60_08375	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
C1O60_08380	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
C1O60_08385	COG0134	indole-3-glycerol-phosphate synthase activity
C1O60_08390	COG0135	phosphoribosylanthranilate isomerase activity
C1O60_08400	COG0159	tryptophan synthase activity
C1O60_08420	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C1O60_08425	COG0257	Belongs to the bacterial ribosomal protein bL36 family
C1O60_08445	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
C1O60_08485	COG0561	phosphatase activity
C1O60_08490	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C1O60_08495	COG2223	nitrite transmembrane transporter activity
C1O60_08510	COG0556	nucleotide-excision repair
C1O60_08515	COG0291	Belongs to the bacterial ribosomal protein bL35 family
C1O60_08520	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
C1O60_08540	COG1074	ATP-dependent DNA helicase activity
C1O60_08550	COG0697	spore germination
C1O60_08555	COG2373	Large extracellular alpha-helical protein
C1O60_08570	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C1O60_08595	COG0372	Belongs to the citrate synthase family
C1O60_08615	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
C1O60_08625	COG1187	pseudouridine synthase activity
C1O60_08635	COG0105	UTP biosynthetic process
C1O60_08640	COG1215	transferase activity, transferring glycosyl groups
C1O60_08645	COG0463	Glycosyl transferase, family 2
C1O60_08655	COG1459	type II secretion system
C1O60_08660	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
C1O60_08670	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C1O60_08685	COG0728	peptidoglycan biosynthetic process
C1O60_08690	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
C1O60_08690	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
C1O60_08700	COG1649	PFAM Uncharacterised BCR, COG1649
C1O60_08705	COG1691	(AIR) carboxylase
C1O60_08710	COG1606	tRNA processing
C1O60_08715	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
C1O60_08720	COG0142	geranyltranstransferase activity
C1O60_08725	COG0142	geranyltranstransferase activity
C1O60_08740	COG2151	metal-sulfur cluster biosynthetic enzyme
C1O60_08755	COG1007	ATP synthesis coupled electron transport
C1O60_08760	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C1O60_08775	COG0713	ATP synthesis coupled electron transport
C1O60_08780	COG0839	Belongs to the complex I subunit 6 family
C1O60_08790	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
C1O60_08795	COG1034	ATP synthesis coupled electron transport
C1O60_08800	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
C1O60_08805	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
C1O60_08810	COG0649	NAD binding
C1O60_08820	COG0726	polysaccharide deacetylase
C1O60_08830	COG0307	riboflavin synthase, alpha
C1O60_08840	COG2264	protein methyltransferase activity
C1O60_08855	COG3210	domain, Protein
C1O60_08865	COG1640	4-alpha-glucanotransferase
C1O60_08875	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C1O60_08880	COG1030	water channel activity
C1O60_08885	COG0358	DNA primase activity
C1O60_08890	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C1O60_08895	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
C1O60_08910	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
C1O60_08915	COG0793	Belongs to the peptidase S41A family
C1O60_08930	COG1643	Atp-dependent helicase
C1O60_08955	COG1450	Type ii and iii secretion system protein
C1O60_08970	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
C1O60_08990	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C1O60_08995	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
C1O60_09005	COG0268	Binds directly to 16S ribosomal RNA
C1O60_09010	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C1O60_09015	COG0028	Belongs to the TPP enzyme family
C1O60_09025	COG0688	phosphatidylethanolamine metabolic process
C1O60_09030	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
C1O60_09035	COG0495	leucyl-tRNA aminoacylation
C1O60_09040	COG3119	arylsulfatase activity
C1O60_09055	COG1166	arginine decarboxylase activity
C1O60_09070	COG3250	beta-galactosidase activity
C1O60_09075	COG3250	beta-galactosidase activity
C1O60_09080	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
C1O60_09085	COG3525	Glycosyl hydrolase, family 20, catalytic domain
C1O60_09105	COG0205	6-phosphofructokinase activity
C1O60_09120	COG0535	radical SAM domain protein
C1O60_09170	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
C1O60_09175	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
C1O60_09190	COG4771	TonB-dependent receptor
C1O60_09210	COG0402	S-adenosylhomocysteine deaminase activity
C1O60_09215	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C1O60_09235	COG1294	oxidase, subunit
C1O60_09240	COG1271	oxidase subunit
C1O60_09250	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C1O60_09270	COG1846	Transcriptional regulator
C1O60_09295	COG2949	membrane
C1O60_09325	COG0514	ATP-dependent DNA helicase (RecQ)
C1O60_09340	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
C1O60_09345	COG0045	succinate-CoA ligase (ADP-forming) activity
C1O60_09420	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C1O60_09425	COG2205	protein histidine kinase activity
C1O60_09440	COG0113	porphobilinogen synthase activity
C1O60_09455	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
C1O60_09475	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
C1O60_09505	COG4106	trans-aconitate 2-methyltransferase activity
C1O60_09520	COG3475	LICD family
C1O60_09525	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
C1O60_09535	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C1O60_09540	COG3475	LICD family
C1O60_09545	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
C1O60_09555	COG2166	iron-sulfur cluster assembly
C1O60_09560	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
C1O60_09570	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C1O60_09575	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C1O60_09580	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
C1O60_09585	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C1O60_09590	COG1131	(ABC) transporter
C1O60_09605	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
C1O60_09620	COG1215	transferase activity, transferring glycosyl groups
C1O60_09635	COG1401	restriction endodeoxyribonuclease activity
C1O60_09635	COG1401	restriction endodeoxyribonuclease activity
C1O60_09650	COG1522	sequence-specific DNA binding
C1O60_09655	COG0436	Aminotransferase
C1O60_09670	COG0423	glycine-tRNA ligase activity
C1O60_09675	COG0656	L-ascorbic acid biosynthetic process
C1O60_09705	COG0714	Associated with various cellular activities
C1O60_09710	COG0154	amidase activity
C1O60_09715	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C1O60_09760	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C1O60_09765	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C1O60_09795	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
C1O60_09805	COG0656	L-ascorbic acid biosynthetic process
C1O60_09815	COG0667	Aldo Keto reductase
C1O60_09820	COG1408	metallophosphoesterase
C1O60_09840	COG2249	NAD(P)H dehydrogenase (quinone) activity
C1O60_09845	COG0789	Transcriptional regulator
C1O60_09865	COG0534	Mate efflux family protein
C1O60_09890	COG1091	dTDP-4-dehydrorhamnose reductase activity
C1O60_09895	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
C1O60_09905	COG1837	Belongs to the UPF0109 family
C1O60_09915	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
C1O60_09920	COG0363	glucosamine-6-phosphate deaminase activity
C1O60_09935	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
C1O60_09945	COG1741	Belongs to the pirin family
C1O60_09965	COG1070	Carbohydrate kinase
C1O60_09980	COG0738	Major facilitator superfamily
C1O60_09995	COG1595	DNA-templated transcription, initiation
C1O60_10020	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
C1O60_10040	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C1O60_10045	COG0232	Belongs to the dGTPase family. Type 2 subfamily
C1O60_10055	COG3586	endonuclease activity
C1O60_10065	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C1O60_10070	COG4608	Belongs to the ABC transporter superfamily
C1O60_10075	COG0444	Belongs to the ABC transporter superfamily
C1O60_10080	COG4166	transmembrane transport
C1O60_10085	COG4239	(ABC) transporter, permease
C1O60_10090	COG0601	transmembrane transport
C1O60_10105	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
C1O60_10110	COG2759	Belongs to the formate--tetrahydrofolate ligase family
C1O60_10115	COG3738	Protein conserved in bacteria
C1O60_10120	COG0151	Belongs to the GarS family
C1O60_10135	COG0811	peptide transport
C1O60_10145	COG0242	peptide deformylase activity
C1O60_10185	COG2010	Cytochrome c
C1O60_10190	COG3258	Cytochrome c
C1O60_10205	COG3274	enterobacterial common antigen metabolic process
C1O60_10210	COG0538	isocitrate dehydrogenase activity
C1O60_10225	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
C1O60_10230	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
C1O60_10235	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
C1O60_10245	COG0668	transmembrane transport
C1O60_10250	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
C1O60_10250	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C1O60_10255	COG0805	protein transport
C1O60_10260	COG1968	undecaprenyl-diphosphatase activity
C1O60_10280	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
C1O60_10290	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
C1O60_10315	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
C1O60_10325	COG1408	metallophosphoesterase
C1O60_10350	COG4974	Belongs to the 'phage' integrase family
C1O60_10370	COG1454	alcohol dehydrogenase
C1O60_10375	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
C1O60_10390	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
C1O60_10390	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
C1O60_10395	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
C1O60_10435	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
C1O60_10445	COG4607	ABC-type enterochelin transport system periplasmic component
C1O60_10450	COG4604	ABC transporter, ATP-binding protein
C1O60_10455	COG4605	iron ion homeostasis
C1O60_10460	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C1O60_10495	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C1O60_10495	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C1O60_10515	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
C1O60_10520	COG2195	Cleaves the N-terminal amino acid of tripeptides
C1O60_10560	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
C1O60_10585	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
C1O60_10625	COG1410	methionine synthase
C1O60_10625	COG0646	methionine synthase
C1O60_10630	COG2966	Psort location CytoplasmicMembrane, score
C1O60_10635	COG3610	response to peptide
C1O60_10645	COG0460	homoserine dehydrogenase
C1O60_10650	COG0527	aspartate kinase activity
C1O60_10660	COG5522	Integral membrane protein (intg_mem_TP0381)
C1O60_10675	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C1O60_10680	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C1O60_10690	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
C1O60_10695	COG0574	Belongs to the PEP-utilizing enzyme family
C1O60_10695	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C1O60_10715	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
C1O60_10725	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
C1O60_10725	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
C1O60_10755	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
C1O60_10760	COG2818	Glycosylase
C1O60_10780	COG3033	Beta-eliminating lyase
C1O60_10795	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C1O60_10795	COG0072	phenylalanine-tRNA ligase activity
C1O60_10820	COG0326	Molecular chaperone. Has ATPase activity
C1O60_10845	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C1O60_10850	COG1959	2 iron, 2 sulfur cluster binding
C1O60_10865	COG0352	thiamine-phosphate diphosphorylase activity
C1O60_10870	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
C1O60_10885	COG3525	Glycosyl hydrolase, family 20, catalytic domain
C1O60_10915	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
C1O60_10925	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C1O60_10945	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C1O60_10965	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C1O60_10980	COG0534	Mate efflux family protein
C1O60_10985	COG0489	protein tyrosine kinase activity
C1O60_11000	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C1O60_11005	COG0339	signal peptide processing
C1O60_11010	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C1O60_11020	COG1538	Outer membrane efflux protein
C1O60_11050	COG4112	unkown
C1O60_11065	COG0038	chloride channel
C1O60_11090	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C1O60_11095	COG0586	Pfam SNARE associated Golgi protein
C1O60_11205	COG1012	belongs to the aldehyde dehydrogenase family
C1O60_11225	COG0753	catalase activity
C1O60_11240	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
C1O60_11245	COG1592	Rubrerythrin
C1O60_11250	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C1O60_11280	COG0489	protein tyrosine kinase activity
C1O60_11285	COG4464	protein tyrosine phosphatase activity
C1O60_11290	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
C1O60_11300	COG2244	polysaccharide biosynthetic process
C1O60_11305	COG1215	transferase activity, transferring glycosyl groups
C1O60_11320	COG1216	Glycosyl transferase, family 2
C1O60_11335	COG0438	transferase activity, transferring glycosyl groups
C1O60_11365	COG1216	Glycosyl transferase, family 2
C1O60_11390	COG2755	lipolytic protein G-D-S-L family
C1O60_11390	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
C1O60_11410	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
C1O60_11415	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C1O60_11420	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
C1O60_11425	COG0281	malic enzyme
C1O60_11425	COG0280	phosphate acetyltransferase
C1O60_11440	COG1472	Belongs to the glycosyl hydrolase 3 family
C1O60_11460	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C1O60_11495	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
C1O60_11500	COG1063	alcohol dehydrogenase
C1O60_11515	COG0714	Associated with various cellular activities
C1O60_11525	COG0193	aminoacyl-tRNA hydrolase activity
C1O60_11530	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C1O60_11545	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
C1O60_11570	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
C1O60_11585	COG0375	protein maturation
C1O60_11610	COG0778	Nitroreductase
C1O60_11615	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C1O60_11630	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C1O60_11630	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C1O60_11660	COG0863	Belongs to the N(4) N(6)-methyltransferase family
C1O60_11685	COG3525	Glycosyl hydrolase, family 20, catalytic domain
C1O60_11690	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
C1O60_11735	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C1O60_11740	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C1O60_11755	COG0318	PFAM AMP-dependent synthetase and ligase
C1O60_11785	COG0339	signal peptide processing
C1O60_11795	COG0018	arginyl-trna synthetase
C1O60_11830	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
C1O60_11835	COG0653	protein targeting
C1O60_11850	COG0494	nUDIX hydrolase