locus-tag	class	description
DMI72_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
DMI72_00010	COG1131	(ABC) transporter
DMI72_00030	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
DMI72_00035	COG0564	pseudouridine synthase activity
DMI72_00055	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
DMI72_00065	COG0513	Belongs to the DEAD box helicase family
DMI72_00075	COG0673	inositol 2-dehydrogenase activity
DMI72_00095	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
DMI72_00115	COG1971	Probably functions as a manganese efflux pump
DMI72_00145	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DMI72_00170	COG0442	prolyl-tRNA aminoacylation
DMI72_00200	COG0531	amino acid
DMI72_00205	COG2066	Belongs to the glutaminase family
DMI72_00215	COG1115	amino acid carrier protein
DMI72_00225	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
DMI72_00230	COG2890	protein-(glutamine-N5) methyltransferase activity
DMI72_00235	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
DMI72_00240	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
DMI72_00260	COG2226	methyltransferase
DMI72_00265	COG0534	Mate efflux family protein
DMI72_00330	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DMI72_00335	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
DMI72_00340	COG3525	Glycosyl hydrolase, family 20, catalytic domain
DMI72_00360	COG1121	(ABC) transporter
DMI72_00365	COG1108	ABC-type Mn2 Zn2 transport systems permease components
DMI72_00370	COG3880	PFAM UvrB UvrC protein
DMI72_00375	COG3869	Catalyzes the specific phosphorylation of arginine residues in
DMI72_00380	COG0542	response to heat
DMI72_00395	COG0179	Fumarylacetoacetate (FAA) hydrolase
DMI72_00400	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DMI72_00415	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
DMI72_00415	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
DMI72_00430	COG0180	Tryptophanyl-tRNA synthetase
DMI72_00440	COG1692	metallophosphoesterase
DMI72_00450	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
DMI72_00465	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DMI72_00470	COG2816	NAD+ diphosphatase activity
DMI72_00480	COG0156	8-amino-7-oxononanoate synthase activity
DMI72_00495	COG0515	serine threonine protein kinase
DMI72_00495	COG3266	domain, Protein
DMI72_00690	COG1598	PFAM Uncharacterised protein family UPF0150
DMI72_00765	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
DMI72_00785	COG0732	type I restriction modification DNA specificity domain
DMI72_00790	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
DMI72_00795	COG3189	MarR family transcriptional regulator
DMI72_00805	COG0181	hydroxymethylbilane synthase activity
DMI72_00810	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
DMI72_00820	COG1469	GTP cyclohydrolase I activity
DMI72_00825	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
DMI72_00830	COG0267	Belongs to the bacterial ribosomal protein bL33 family
DMI72_00835	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
DMI72_00840	COG1940	carbohydrate kinase activity
DMI72_00855	COG0494	nUDIX hydrolase
DMI72_00860	COG1566	PFAM secretion protein HlyD family protein
DMI72_00865	COG0577	efflux transmembrane transporter activity
DMI72_00865	COG1136	(ABC) transporter
DMI72_00870	COG1136	(ABC) transporter
DMI72_00870	COG0577	efflux transmembrane transporter activity
DMI72_00875	COG1538	Outer membrane efflux protein
DMI72_00890	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DMI72_00905	COG1720	tRNA m6t6A37 methyltransferase activity
DMI72_00910	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
DMI72_00915	COG0540	Belongs to the ATCase OTCase family
DMI72_00920	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
DMI72_00935	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
DMI72_00940	COG2957	Belongs to the agmatine deiminase family
DMI72_00950	COG0750	zinc metalloprotease
DMI72_00960	COG3119	arylsulfatase activity
DMI72_00970	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
DMI72_00970	COG1918	ferrous iron import across plasma membrane
DMI72_01035	COG1475	DNA binding
DMI72_01090	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DMI72_01095	COG0601	transmembrane transport
DMI72_01160	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DMI72_01165	COG1132	(ABC) transporter
DMI72_01170	COG1132	(ABC) transporter
DMI72_01185	COG1127	ABC transporter
DMI72_01190	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
DMI72_01220	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DMI72_01235	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
DMI72_01240	COG0504	CTP synthase activity
DMI72_01245	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DMI72_01270	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DMI72_01275	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
DMI72_01285	COG1322	Protein conserved in bacteria
DMI72_01290	COG0546	phosphoglycolate phosphatase activity
DMI72_01295	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
DMI72_01305	COG4591	ABC-type transport system involved in lipoprotein release permease component
DMI72_01340	COG0657	acetylesterase activity
DMI72_01340	COG2755	lipolytic protein G-D-S-L family
DMI72_01350	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
DMI72_01370	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
DMI72_01405	COG0346	lactoylglutathione lyase activity
DMI72_01420	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
DMI72_01425	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
DMI72_01435	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
DMI72_01435	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
DMI72_01475	COG0028	Belongs to the TPP enzyme family
DMI72_01495	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
DMI72_01515	COG0471	metal ion transport
DMI72_01525	COG0351	phosphomethylpyrimidine kinase
DMI72_01590	COG0242	peptide deformylase activity
DMI72_01605	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DMI72_01610	COG1393	Belongs to the ArsC family
DMI72_01615	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
DMI72_01625	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
DMI72_01640	COG1187	pseudouridine synthase activity
DMI72_01665	COG0539	negative regulation of cytoplasmic translation
DMI72_01715	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
DMI72_01720	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
DMI72_01725	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
DMI72_01730	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DMI72_01770	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DMI72_01795	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
DMI72_01795	COG0662	Cupin 2, conserved barrel domain protein
DMI72_01805	COG0416	fatty acid biosynthetic process
DMI72_01810	COG0333	Belongs to the bacterial ribosomal protein bL32 family
DMI72_01820	COG0537	adenosine 5'-monophosphoramidase activity
DMI72_01830	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
DMI72_01835	COG0228	four-way junction DNA binding
DMI72_01855	COG1862	Preprotein translocase
DMI72_01865	COG0220	tRNA (guanine-N7-)-methyltransferase activity
DMI72_01875	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
DMI72_01880	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
DMI72_01885	COG0776	regulation of translation
DMI72_01920	COG0811	peptide transport
DMI72_01940	COG3250	beta-galactosidase activity
DMI72_01945	COG0525	valine-tRNA ligase activity
DMI72_01960	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
DMI72_01965	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
DMI72_01970	COG0255	Belongs to the universal ribosomal protein uL29 family
DMI72_01975	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
DMI72_01980	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
DMI72_01985	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
DMI72_01995	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
DMI72_02000	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
DMI72_02005	COG0089	rRNA binding
DMI72_02010	COG0088	Forms part of the polypeptide exit tunnel
DMI72_02015	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
DMI72_02020	COG0051	transcription antitermination factor activity, RNA binding
DMI72_02025	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
DMI72_02030	COG0049	tRNA binding
DMI72_02035	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
DMI72_02045	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
DMI72_02055	COG3852	Histidine kinase
DMI72_02060	COG2204	response regulator
DMI72_02070	COG1722	exodeoxyribonuclease VII activity
DMI72_02075	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
DMI72_02090	COG0795	lipopolysaccharide-transporting ATPase activity
DMI72_02095	COG1160	GTP binding
DMI72_02100	COG0444	Belongs to the ABC transporter superfamily
DMI72_02120	COG1136	(ABC) transporter
DMI72_02120	COG0577	efflux transmembrane transporter activity
DMI72_02135	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
DMI72_02185	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
DMI72_02195	COG0799	negative regulation of ribosome biogenesis
DMI72_02200	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DMI72_02260	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
DMI72_02275	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
DMI72_02285	COG0300	oxidoreductase activity
DMI72_02305	COG0038	chloride channel
DMI72_02315	COG3525	Glycosyl hydrolase, family 20, catalytic domain
DMI72_02330	COG0076	glutamate decarboxylase activity
DMI72_02345	COG0167	dihydroorotate dehydrogenase activity
DMI72_02350	COG0352	thiamine-phosphate diphosphorylase activity
DMI72_02370	COG1253	flavin adenine dinucleotide binding
DMI72_02375	COG1253	flavin adenine dinucleotide binding
DMI72_02385	COG1185	polyribonucleotide nucleotidyltransferase activity
DMI72_02390	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
DMI72_02395	COG0110	maltose O-acetyltransferase activity
DMI72_02430	COG0101	tRNA pseudouridine synthase activity
DMI72_02435	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
DMI72_02455	COG4968	Prepilin-type N-terminal cleavage methylation domain
DMI72_02470	COG3525	Glycosyl hydrolase, family 20, catalytic domain
DMI72_02475	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
DMI72_02495	COG1136	(ABC) transporter
DMI72_02500	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
DMI72_02510	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
DMI72_02535	COG3525	Glycosyl hydrolase, family 20, catalytic domain
DMI72_02540	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
DMI72_02545	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
DMI72_02560	COG0828	Belongs to the bacterial ribosomal protein bS21 family
DMI72_02565	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
DMI72_02580	COG2814	Major facilitator Superfamily
DMI72_02595	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DMI72_02600	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DMI72_02600	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DMI72_02605	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
DMI72_02610	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DMI72_02615	COG0552	protein localization to endoplasmic reticulum
DMI72_02620	COG0820	rRNA (adenine-C2-)-methyltransferase activity
DMI72_02640	COG1058	Belongs to the CinA family
DMI72_02640	COG1546	Belongs to the CinA family
DMI72_02650	COG0456	acetyltransferase
DMI72_02675	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
DMI72_02680	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
DMI72_02685	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
DMI72_02690	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
DMI72_02705	COG0758	DNA mediated transformation
DMI72_02710	COG1686	Belongs to the peptidase S11 family
DMI72_02715	COG0012	GTP binding
DMI72_02720	COG0404	The glycine cleavage system catalyzes the degradation of glycine
DMI72_02730	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
DMI72_02730	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
DMI72_02745	COG3119	arylsulfatase activity
DMI72_02775	COG2259	Doxx family
DMI72_02780	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
DMI72_02810	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
DMI72_02830	COG2326	polyphosphate kinase activity
DMI72_02835	COG1349	DNA-binding transcription factor activity
DMI72_02850	COG1104	cysteine desulfurase activity
DMI72_02855	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
DMI72_02860	COG1162	GTPase activity
DMI72_02880	COG0742	ribosomal rna small subunit methyltransferase
DMI72_02895	COG2326	polyphosphate kinase activity
DMI72_02910	COG5434	Belongs to the glycosyl hydrolase 28 family
DMI72_02920	COG1073	alpha beta
DMI72_02925	COG0802	atpase or kinase
DMI72_02930	COG0261	This protein binds to 23S rRNA in the presence of protein L20
DMI72_02935	COG0211	Belongs to the bacterial ribosomal protein bL27 family
DMI72_02940	COG0735	belongs to the Fur family
DMI72_02945	COG0396	ATPase activity
DMI72_02950	COG0719	Fe-S assembly protein
DMI72_02955	COG0719	Fe-S assembly protein
DMI72_02975	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
DMI72_03015	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
DMI72_03035	COG0355	proton-transporting ATP synthase activity, rotational mechanism
DMI72_03040	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
DMI72_03045	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
DMI72_03050	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
DMI72_03055	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
DMI72_03060	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
DMI72_03070	COG0356	it plays a direct role in the translocation of protons across the membrane
DMI72_03130	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
DMI72_03155	COG1045	serine acetyltransferase
DMI72_03160	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
DMI72_03165	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
DMI72_03170	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
DMI72_03180	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
DMI72_03190	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
DMI72_03195	COG0047	phosphoribosylformylglycinamidine synthase activity
DMI72_03205	COG1363	Peptidase, m42
DMI72_03220	COG1077	Cell shape determining protein MreB Mrl
DMI72_03225	COG1530	ribonuclease E activity
DMI72_03250	COG0848	biopolymer transport protein
DMI72_03265	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
DMI72_03285	COG0134	indole-3-glycerol-phosphate synthase activity
DMI72_03290	COG0792	nuclease activity
DMI72_03300	COG1253	flavin adenine dinucleotide binding
DMI72_03310	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
DMI72_03325	COG0137	argininosuccinate synthase activity
DMI72_03340	COG0149	triose-phosphate isomerase activity
DMI72_03375	COG1040	competence protein
DMI72_03385	COG3956	TIGRFAM MazG family protein
DMI72_03405	COG1663	tetraacyldisaccharide 4'-kinase activity
DMI72_03415	COG0612	Peptidase, M16
DMI72_03435	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
DMI72_03470	COG0673	inositol 2-dehydrogenase activity
DMI72_03475	COG3034	peptidoglycan biosynthetic process
DMI72_03495	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
DMI72_03500	COG0424	maF-like protein
DMI72_03505	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
DMI72_03510	COG0515	serine threonine protein kinase
DMI72_03510	COG2815	serine threonine protein kinase
DMI72_03535	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
DMI72_03545	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
DMI72_03555	COG0571	ribonuclease III activity
DMI72_03575	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
DMI72_03590	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
DMI72_03610	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
DMI72_03625	COG2226	methyltransferase
DMI72_03635	COG2076	Multidrug Resistance protein
DMI72_03855	COG2255	four-way junction helicase activity
DMI72_03860	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DMI72_03865	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
DMI72_03870	COG1215	transferase activity, transferring glycosyl groups
DMI72_03875	COG1216	Glycosyl transferase, family 2
DMI72_03875	COG0463	Glycosyl transferase, family 2
DMI72_03900	COG0438	transferase activity, transferring glycosyl groups
DMI72_03910	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
DMI72_03920	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
DMI72_03930	COG0482	sulfurtransferase activity
DMI72_03935	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
DMI72_03945	COG2860	membrane
DMI72_03950	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
DMI72_03955	COG2001	Belongs to the MraZ family
DMI72_03960	COG0275	rRNA processing
DMI72_03970	COG0768	penicillin binding
DMI72_03975	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
DMI72_03980	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
DMI72_03985	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DMI72_03990	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
DMI72_04005	COG0772	Belongs to the SEDS family
DMI72_04010	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
DMI72_04015	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
DMI72_04020	COG1181	Belongs to the D-alanine--D-alanine ligase family
DMI72_04030	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
DMI72_04035	COG0860	N-Acetylmuramoyl-L-alanine amidase
DMI72_04040	COG0321	lipoyl(octanoyl) transferase activity
DMI72_04045	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
DMI72_04050	COG0066	3-isopropylmalate dehydratase activity
DMI72_04060	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DMI72_04070	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
DMI72_04080	COG4608	Belongs to the ABC transporter superfamily
DMI72_04085	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
DMI72_04100	COG2877	3-deoxy-8-phosphooctulonate synthase activity
DMI72_04115	COG1137	ATPase activity
DMI72_04125	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
DMI72_04150	COG0017	Asparaginyl-tRNA synthetase
DMI72_04160	COG3118	belongs to the thioredoxin family
DMI72_04210	COG0583	DNA-binding transcription factor activity
DMI72_04215	COG2855	membrane
DMI72_04220	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
DMI72_04235	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DMI72_04245	COG0602	queuosine metabolic process
DMI72_04250	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
DMI72_04255	COG0217	transcriptional regulatory protein
DMI72_04260	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
DMI72_04265	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
DMI72_04265	COG4651	solute:proton antiporter activity
DMI72_04275	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
DMI72_04280	COG4864	UPF0365 protein
DMI72_04290	COG2022	thiamine diphosphate biosynthetic process
DMI72_04295	COG0531	amino acid
DMI72_04310	COG0019	diaminopimelate decarboxylase activity
DMI72_04315	COG0191	fructose-bisphosphate aldolase activity
DMI72_04355	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
DMI72_04385	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DMI72_04390	COG0517	IMP dehydrogenase activity
DMI72_04390	COG0516	GMP reductase activity
DMI72_04395	COG0518	GMP synthase (glutamine-hydrolyzing) activity
DMI72_04395	COG0519	Catalyzes the synthesis of GMP from XMP
DMI72_04405	COG0546	phosphoglycolate phosphatase activity
DMI72_04425	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
DMI72_04440	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
DMI72_04445	COG0196	riboflavin kinase activity
DMI72_04450	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
DMI72_04465	COG1408	metallophosphoesterase
DMI72_04475	COG1216	Glycosyl transferase, family 2
DMI72_04475	COG1442	glycosyl transferase family 8
DMI72_04485	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DMI72_04490	COG1216	Glycosyl transferase, family 2
DMI72_04510	COG2755	lipolytic protein G-D-S-L family
DMI72_04510	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
DMI72_04530	COG0490	domain, Protein
DMI72_04530	COG0471	metal ion transport
DMI72_04570	COG0588	phosphoglycerate mutase activity
DMI72_04575	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DMI72_04585	COG0477	Major facilitator Superfamily
DMI72_04590	COG1607	acyl-coa hydrolase
DMI72_04610	COG1525	nuclease
DMI72_04625	COG1475	DNA binding
DMI72_04630	COG3969	phosphoadenosine phosphosulfate
DMI72_04710	COG3015	lipoprotein NlpE involved in copper resistance
DMI72_04780	COG0305	Participates in initiation and elongation during chromosome replication
DMI72_04890	COG0473	3-isopropylmalate dehydrogenase activity
DMI72_04915	COG2873	o-acetylhomoserine
DMI72_04920	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
DMI72_04925	COG0535	radical SAM domain protein
DMI72_04940	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
DMI72_04945	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
DMI72_04955	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
DMI72_04965	COG1013	pyruvate-flavodoxin oxidoreductase activity
DMI72_04965	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
DMI72_04965	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
DMI72_04965	COG0674	pyruvate-flavodoxin oxidoreductase activity
DMI72_04975	COG1733	regulation of RNA biosynthetic process
DMI72_04985	COG0107	imidazoleglycerol-phosphate synthase activity
DMI72_04995	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
DMI72_05005	COG1643	Atp-dependent helicase
DMI72_05010	COG0440	acetolactate synthase activity
DMI72_05015	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DMI72_05025	COG0445	tRNA wobble uridine modification
DMI72_05035	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DMI72_05035	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DMI72_05040	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
DMI72_05050	COG0592	DNA-directed DNA polymerase activity
DMI72_05075	COG1388	LysM domain
DMI72_05075	COG0791	NLP P60 protein
DMI72_05080	COG0084	hydrolase, TatD family'
DMI72_05090	COG3250	beta-galactosidase activity
DMI72_05105	COG2205	protein histidine kinase activity
DMI72_05110	COG0745	RESPONSE REGULATOR receiver
DMI72_05120	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
DMI72_05130	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
DMI72_05150	COG0542	response to heat
DMI72_05200	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
DMI72_05210	COG0659	secondary active sulfate transmembrane transporter activity
DMI72_05215	COG0165	Argininosuccinate lyase
DMI72_05230	COG0148	phosphopyruvate hydratase activity
DMI72_05235	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
DMI72_05245	COG3481	metal-dependent phosphohydrolase, HD sub domain
DMI72_05255	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DMI72_05260	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
DMI72_05310	COG2985	domain, Protein
DMI72_05310	COG0490	domain, Protein
DMI72_05325	COG0471	metal ion transport
DMI72_05350	COG2194	sulfuric ester hydrolase activity
DMI72_05360	COG1592	Rubrerythrin
DMI72_05370	COG1363	Peptidase, m42
DMI72_05375	COG3525	Glycosyl hydrolase, family 20, catalytic domain
DMI72_05385	COG1785	Belongs to the alkaline phosphatase family
DMI72_05390	COG1970	mechanosensitive ion channel activity
DMI72_05395	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DMI72_05415	COG2217	Heavy metal translocating P-type atpase
DMI72_05420	COG0497	DNA recombination
DMI72_05425	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
DMI72_05425	COG0321	lipoyl(octanoyl) transferase activity
DMI72_05430	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
DMI72_05465	COG0022	dehydrogenase e1 component
DMI72_05470	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
DMI72_05480	COG0789	Transcriptional regulator
DMI72_05485	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DMI72_05490	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DMI72_05495	COG3210	domain, Protein
DMI72_05545	COG3409	Peptidoglycan-binding domain 1 protein
DMI72_05545	COG5632	N-Acetylmuramoyl-L-alanine amidase
DMI72_05550	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
DMI72_05575	COG1690	Belongs to the RtcB family
DMI72_05585	COG2814	Major facilitator Superfamily
DMI72_05595	COG2096	Adenosyltransferase
DMI72_05605	COG0557	exoribonuclease II activity
DMI72_05615	COG0826	peptidase U32
DMI72_05620	COG0285	dihydrofolate synthase activity
DMI72_05635	COG0673	inositol 2-dehydrogenase activity
DMI72_05640	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
DMI72_05645	COG0737	Belongs to the 5'-nucleotidase family
DMI72_05655	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
DMI72_05660	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
DMI72_05665	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
DMI72_05680	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
DMI72_05685	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
DMI72_05690	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
DMI72_05695	COG0200	Binds to the 23S rRNA
DMI72_05700	COG0201	protein transport
DMI72_05705	COG0563	adenylate kinase activity
DMI72_05710	COG0024	Methionine aminopeptidase
DMI72_05725	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
DMI72_05730	COG1442	glycosyl transferase family 8
DMI72_05740	COG1216	Glycosyl transferase, family 2
DMI72_05750	COG1216	Glycosyl transferase, family 2
DMI72_05765	COG1216	Glycosyl transferase, family 2
DMI72_05770	COG0693	protein deglycase activity
DMI72_05775	COG0508	dehydrogenase complex catalyzes the overall conversion of
DMI72_05780	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
DMI72_05785	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
DMI72_05795	COG1966	Carbon starvation protein
DMI72_05810	COG3119	arylsulfatase activity
DMI72_05815	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
DMI72_05820	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
DMI72_05825	COG0195	Participates in both transcription termination and antitermination
DMI72_05830	COG0708	Exodeoxyribonuclease III
DMI72_05835	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
DMI72_05840	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
DMI72_05845	COG2006	4fe-4S ferredoxin, iron-sulfur binding domain protein
DMI72_05855	COG1131	(ABC) transporter
DMI72_05855	COG0842	Transport permease protein
DMI72_05855	COG1716	ATPase activity
DMI72_05875	COG0724	RNA recognition motif
DMI72_05880	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
DMI72_05900	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
DMI72_05910	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
DMI72_05915	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DMI72_05930	COG1490	D-aminoacyl-tRNA deacylase activity
DMI72_05945	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
DMI72_05950	COG1053	succinate dehydrogenase
DMI72_06000	COG1028	Short-chain dehydrogenase reductase Sdr
DMI72_06010	COG0488	(ABC) transporter
DMI72_06020	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
DMI72_06030	COG1253	flavin adenine dinucleotide binding
DMI72_06035	COG1028	Short-chain dehydrogenase reductase Sdr
DMI72_06045	COG1073	alpha beta
DMI72_06055	COG0667	Aldo Keto reductase
DMI72_06110	COG2267	carboxylic ester hydrolase activity
DMI72_06115	COG2095	MarC family integral membrane protein
DMI72_06155	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
DMI72_06160	COG0488	(ABC) transporter
DMI72_06170	COG0697	spore germination
DMI72_06180	COG0215	cysteine-tRNA ligase activity
DMI72_06190	COG3119	arylsulfatase activity
DMI72_06200	COG0481	GTPase activity
DMI72_06220	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
DMI72_06225	COG0085	RNA polymerase activity
DMI72_06230	COG0222	ribosome binding
DMI72_06235	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
DMI72_06240	COG0081	regulation of translation
DMI72_06245	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
DMI72_06250	COG0250	Participates in transcription elongation, termination and antitermination
DMI72_06265	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
DMI72_06285	COG0740	serine-type endopeptidase activity
DMI72_06290	COG0544	peptidyl-prolyl cis-trans isomerase activity
DMI72_06310	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
DMI72_06330	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DMI72_06375	COG2226	methyltransferase
DMI72_06385	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
DMI72_06415	COG1902	pentaerythritol trinitrate reductase activity
DMI72_06415	COG0446	pyridine nucleotide-disulphide oxidoreductase
DMI72_06425	COG3119	arylsulfatase activity
DMI72_06430	COG0514	ATP-dependent DNA helicase (RecQ)
DMI72_06450	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
DMI72_06455	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DMI72_06520	COG1858	cytochrome C peroxidase
DMI72_06525	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
DMI72_06530	COG0590	tRNA wobble adenosine to inosine editing
DMI72_06535	COG1940	carbohydrate kinase activity
DMI72_06540	COG2217	Heavy metal translocating P-type atpase
DMI72_06545	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
DMI72_06550	COG0237	dephospho-CoA kinase activity
DMI72_06580	COG1363	Peptidase, m42
DMI72_06585	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
DMI72_06595	COG0006	proline dipeptidase activity
DMI72_06600	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
DMI72_06620	COG5002	protein histidine kinase activity
DMI72_06625	COG0745	RESPONSE REGULATOR receiver
DMI72_06630	COG0129	dihydroxy-acid dehydratase activity
DMI72_06655	COG1368	sulfuric ester hydrolase activity
DMI72_06690	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
DMI72_06695	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
DMI72_06720	COG0534	Mate efflux family protein
DMI72_06725	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
DMI72_06740	COG1876	peptidase activity
DMI72_06785	COG3209	COG3209 Rhs family protein
DMI72_06820	COG3209	COG3209 Rhs family protein
DMI72_06870	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
DMI72_06875	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
DMI72_06880	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
DMI72_06885	COG2205	protein histidine kinase activity
DMI72_06895	COG1262	PFAM Formylglycine-generating sulfatase enzyme
DMI72_06905	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DMI72_06920	COG0667	Aldo Keto reductase
DMI72_06925	COG0789	Transcriptional regulator
DMI72_06975	COG0714	Associated with various cellular activities
DMI72_06980	COG2311	Membrane
DMI72_07005	COG1090	epimerase
DMI72_07020	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
DMI72_07025	COG1119	ATPase activity
DMI72_07035	COG2186	Transcriptional regulator
DMI72_07055	COG0148	phosphopyruvate hydratase activity
DMI72_07065	COG0436	Aminotransferase
DMI72_07070	COG1477	protein flavinylation
DMI72_07085	COG0227	Belongs to the bacterial ribosomal protein bL28 family
DMI72_07100	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
DMI72_07120	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
DMI72_07130	COG1199	ATP-dependent helicase activity
DMI72_07135	COG1122	ATPase activity
DMI72_07160	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
DMI72_07165	COG0598	Magnesium transport protein CorA
DMI72_07170	COG0359	binds to the 23S rRNA
DMI72_07175	COG0138	bifunctional purine biosynthesis protein purh
DMI72_07180	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
DMI72_07185	COG0736	holo-[acyl-carrier-protein] synthase activity
DMI72_07195	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
DMI72_07200	COG3409	Peptidoglycan-binding domain 1 protein
DMI72_07200	COG5632	N-Acetylmuramoyl-L-alanine amidase
DMI72_07205	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
DMI72_07215	COG0437	4 iron, 4 sulfur cluster binding
DMI72_07235	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
DMI72_07285	COG0284	orotidine-5'-phosphate decarboxylase activity
DMI72_07305	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
DMI72_07310	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
DMI72_07330	COG2003	Belongs to the UPF0758 family
DMI72_07335	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
DMI72_07335	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
DMI72_07340	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
DMI72_07345	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
DMI72_07350	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
DMI72_07355	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
DMI72_07360	COG0322	excinuclease ABC activity
DMI72_07365	COG0811	peptide transport
DMI72_07370	COG0848	biopolymer transport protein
DMI72_07380	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
DMI72_07390	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
DMI72_07400	COG1482	cell wall glycoprotein biosynthetic process
DMI72_07410	COG1757	Na H antiporter
DMI72_07415	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DMI72_07420	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
DMI72_07425	COG0505	Belongs to the CarA family
DMI72_07430	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
DMI72_07440	COG0067	glutamate synthase
DMI72_07440	COG0069	glutamate synthase activity
DMI72_07440	COG0070	glutamate synthase
DMI72_07450	COG0706	membrane insertase activity
DMI72_07455	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
DMI72_07465	COG0230	Belongs to the bacterial ribosomal protein bL34 family
DMI72_07480	COG2755	lipolytic protein G-D-S-L family
DMI72_07480	COG0657	acetylesterase activity
DMI72_07490	COG0676	glucose-6-phosphate 1-epimerase activity
DMI72_07495	COG0259	pyridoxamine-phosphate oxidase activity
DMI72_07510	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
DMI72_07530	COG1760	l-serine dehydratase
DMI72_07535	COG0492	ferredoxin-NADP+ reductase activity
DMI72_07535	COG3118	belongs to the thioredoxin family
DMI72_07590	COG1408	metallophosphoesterase
DMI72_07600	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
DMI72_07605	COG0545	Peptidyl-prolyl cis-trans isomerase
DMI72_07625	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
DMI72_07635	COG0826	peptidase U32
DMI72_07645	COG1262	PFAM Formylglycine-generating sulfatase enzyme
DMI72_07675	COG0581	inorganic phosphate transmembrane transporter activity
DMI72_07680	COG0573	inorganic phosphate transmembrane transporter activity
DMI72_07690	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
DMI72_07700	COG2017	converts alpha-aldose to the beta-anomer
DMI72_07715	COG0612	Peptidase, M16
DMI72_07750	COG0233	cytoplasmic translational termination
DMI72_07755	COG0528	UMP kinase activity
DMI72_07760	COG0668	transmembrane transport
DMI72_07765	COG0450	alkyl hydroperoxide reductase
DMI72_07770	COG0733	neurotransmitter:sodium symporter activity
DMI72_07785	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
DMI72_07795	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DMI72_07800	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DMI72_07805	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
DMI72_07830	COG0842	Transport permease protein
DMI72_07835	COG0842	Transport permease protein
DMI72_07840	COG1131	(ABC) transporter
DMI72_07850	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
DMI72_07855	COG1183	phosphatidylcholine synthase activity
DMI72_07865	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
DMI72_07875	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
DMI72_07880	COG1028	Short-chain dehydrogenase reductase Sdr
DMI72_07905	COG0156	8-amino-7-oxononanoate synthase activity
DMI72_07930	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
DMI72_07935	COG0124	histidyl-tRNA synthetase
DMI72_07940	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
DMI72_07945	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
DMI72_07950	COG0298	carbon dioxide binding
DMI72_07975	COG0438	transferase activity, transferring glycosyl groups
DMI72_07985	COG0443	Heat shock 70 kDa protein
DMI72_07990	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
DMI72_08050	COG0632	four-way junction helicase activity
DMI72_08060	COG0126	phosphoglycerate kinase activity
DMI72_08075	COG1082	Xylose isomerase domain protein TIM barrel
DMI72_08080	COG0515	serine threonine protein kinase
DMI72_08080	COG2815	serine threonine protein kinase
DMI72_08085	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
DMI72_08095	COG2271	Major facilitator Superfamily
DMI72_08110	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
DMI72_08120	COG0037	tRNA processing
DMI72_08125	COG0254	rRNA binding
DMI72_08160	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
DMI72_08165	COG0039	L-malate dehydrogenase activity
DMI72_08405	COG0778	Nitroreductase
DMI72_08410	COG0564	pseudouridine synthase activity
DMI72_08440	COG1126	abc transporter atp-binding protein
DMI72_08445	COG0765	amino acid transport
DMI72_08455	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
DMI72_08460	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
DMI72_08480	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
DMI72_08505	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
DMI72_08510	COG1872	DUF167
DMI72_08515	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
DMI72_08520	COG0484	heat shock protein binding
DMI72_08525	COG1385	rRNA (uridine-N3-)-methyltransferase activity
DMI72_08535	COG5434	Belongs to the glycosyl hydrolase 28 family
DMI72_08555	COG0277	FAD linked oxidase domain protein
DMI72_08580	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
DMI72_08585	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
DMI72_08600	COG0131	Imidazoleglycerol-phosphate dehydratase
DMI72_08605	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
DMI72_08610	COG0360	Binds together with S18 to 16S ribosomal RNA
DMI72_08620	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
DMI72_08635	COG1686	Belongs to the peptidase S11 family
DMI72_08640	COG0205	6-phosphofructokinase activity
DMI72_08650	COG0428	transporter
DMI72_08655	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DMI72_08670	COG3977	Valine--pyruvate aminotransferase
DMI72_08675	COG1561	YicC-like family, N-terminal region
DMI72_08685	COG0471	metal ion transport
DMI72_08685	COG3273	potassium ion transport
DMI72_08690	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DMI72_08705	COG1575	Belongs to the MenA family. Type 1 subfamily
DMI72_08745	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DMI72_08745	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DMI72_08765	COG0202	RNA polymerase activity
DMI72_08770	COG0203	ribosomal protein L17
DMI72_08775	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
DMI72_08785	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DMI72_08800	COG2885	chlorophyll binding
DMI72_08870	COG0667	Aldo Keto reductase
DMI72_08875	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
DMI72_08895	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
DMI72_08900	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
DMI72_08905	COG0134	indole-3-glycerol-phosphate synthase activity
DMI72_08910	COG0135	phosphoribosylanthranilate isomerase activity
DMI72_08920	COG0159	tryptophan synthase activity
DMI72_08940	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
DMI72_08945	COG0257	Belongs to the bacterial ribosomal protein bL36 family
DMI72_08955	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
DMI72_08985	COG0561	phosphatase activity
DMI72_08990	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DMI72_08995	COG2223	nitrite transmembrane transporter activity
DMI72_09000	COG1111	helicase
DMI72_09000	COG1205	dead DEAH box helicase
DMI72_09010	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
DMI72_09045	COG0556	nucleotide-excision repair
DMI72_09055	COG0291	Belongs to the bacterial ribosomal protein bL35 family
DMI72_09060	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
DMI72_09065	COG0750	zinc metalloprotease
DMI72_09080	COG1074	ATP-dependent DNA helicase activity
DMI72_09090	COG0697	spore germination
DMI72_09100	COG1002	Type II restriction enzyme, methylase subunits
DMI72_09105	COG1061	Type III restriction enzyme res subunit
DMI72_09110	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
DMI72_09115	COG2373	Large extracellular alpha-helical protein
DMI72_09120	COG1979	alcohol dehydrogenase
DMI72_09130	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
DMI72_09155	COG0372	Belongs to the citrate synthase family
DMI72_09170	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
DMI72_09180	COG1187	pseudouridine synthase activity
DMI72_09190	COG0105	UTP biosynthetic process
DMI72_09195	COG1215	transferase activity, transferring glycosyl groups
DMI72_09200	COG0463	Glycosyl transferase, family 2
DMI72_09210	COG1459	type II secretion system
DMI72_09215	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
DMI72_09225	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
DMI72_09240	COG0728	peptidoglycan biosynthetic process
DMI72_09245	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
DMI72_09245	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
DMI72_09255	COG1649	PFAM Uncharacterised BCR, COG1649
DMI72_09260	COG1691	(AIR) carboxylase
DMI72_09265	COG0037	tRNA processing
DMI72_09270	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
DMI72_09275	COG0142	geranyltranstransferase activity
DMI72_09290	COG2151	metal-sulfur cluster biosynthetic enzyme
DMI72_09305	COG1007	ATP synthesis coupled electron transport
DMI72_09310	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DMI72_09325	COG0713	ATP synthesis coupled electron transport
DMI72_09330	COG0839	Belongs to the complex I subunit 6 family
DMI72_09340	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
DMI72_09345	COG1034	ATP synthesis coupled electron transport
DMI72_09350	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
DMI72_09355	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
DMI72_09360	COG0649	NAD binding
DMI72_09370	COG0726	polysaccharide deacetylase
DMI72_09380	COG0307	riboflavin synthase, alpha
DMI72_09390	COG2264	protein methyltransferase activity
DMI72_09395	COG3210	domain, Protein
DMI72_09400	COG1640	4-alpha-glucanotransferase
DMI72_09415	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DMI72_09420	COG1030	water channel activity
DMI72_09425	COG0358	DNA primase activity
DMI72_09430	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
DMI72_09435	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
DMI72_09450	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
DMI72_09455	COG0793	Belongs to the peptidase S41A family
DMI72_09470	COG1643	Atp-dependent helicase
DMI72_09475	COG1643	Atp-dependent helicase
DMI72_09500	COG1450	Type ii and iii secretion system protein
DMI72_09520	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
DMI72_09540	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
DMI72_09545	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
DMI72_09555	COG0268	Binds directly to 16S ribosomal RNA
DMI72_09560	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DMI72_09565	COG0028	Belongs to the TPP enzyme family
DMI72_09575	COG0688	phosphatidylethanolamine metabolic process
DMI72_09580	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
DMI72_09585	COG0495	leucyl-tRNA aminoacylation
DMI72_09590	COG3119	arylsulfatase activity
DMI72_09605	COG1166	arginine decarboxylase activity
DMI72_09615	COG3250	beta-galactosidase activity
DMI72_09620	COG3250	beta-galactosidase activity
DMI72_09625	COG3250	beta-galactosidase activity
DMI72_09630	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
DMI72_09635	COG3525	Glycosyl hydrolase, family 20, catalytic domain
DMI72_09650	COG0205	6-phosphofructokinase activity
DMI72_09685	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
DMI72_09690	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
DMI72_09695	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
DMI72_09710	COG4771	TonB-dependent receptor
DMI72_09735	COG0402	S-adenosylhomocysteine deaminase activity
DMI72_09760	COG1196	nuclear chromosome segregation
DMI72_09795	COG0508	dehydrogenase complex catalyzes the overall conversion of
DMI72_09805	COG1294	oxidase, subunit
DMI72_09810	COG1271	oxidase subunit
DMI72_09820	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DMI72_09840	COG1846	Transcriptional regulator
DMI72_09865	COG2949	membrane
DMI72_09895	COG0514	ATP-dependent DNA helicase (RecQ)
DMI72_09910	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
DMI72_09915	COG0045	succinate-CoA ligase (ADP-forming) activity
DMI72_09920	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
DMI72_09960	COG0204	Acyl-transferase
DMI72_09960	COG0318	PFAM AMP-dependent synthetase and ligase
DMI72_10000	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DMI72_10005	COG2205	protein histidine kinase activity
DMI72_10020	COG0113	porphobilinogen synthase activity
DMI72_10035	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
DMI72_10040	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
DMI72_10055	COG0732	type I restriction modification DNA specificity domain
DMI72_10070	COG0732	type I restriction modification DNA specificity domain
DMI72_10080	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
DMI72_10105	COG4106	trans-aconitate 2-methyltransferase activity
DMI72_10120	COG3475	LICD family
DMI72_10125	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
DMI72_10135	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DMI72_10140	COG3475	LICD family
DMI72_10145	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
DMI72_10155	COG2166	iron-sulfur cluster assembly
DMI72_10160	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
DMI72_10170	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DMI72_10175	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
DMI72_10180	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
DMI72_10185	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DMI72_10190	COG1131	(ABC) transporter
DMI72_10205	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
DMI72_10220	COG1215	transferase activity, transferring glycosyl groups
DMI72_10230	COG2967	ApaG domain
DMI72_10240	COG1522	sequence-specific DNA binding
DMI72_10245	COG0436	Aminotransferase
DMI72_10260	COG0423	glycine-tRNA ligase activity
DMI72_10265	COG0656	L-ascorbic acid biosynthetic process
DMI72_10295	COG2304	oxidoreductase activity
DMI72_10310	COG0714	Associated with various cellular activities
DMI72_10315	COG0154	amidase activity
DMI72_10320	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DMI72_10360	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DMI72_10365	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DMI72_10375	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
DMI72_10375	COG2755	lipolytic protein G-D-S-L family
DMI72_10410	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
DMI72_10420	COG0656	L-ascorbic acid biosynthetic process
DMI72_10430	COG0667	Aldo Keto reductase
DMI72_10435	COG1408	metallophosphoesterase
DMI72_10455	COG2249	NAD(P)H dehydrogenase (quinone) activity
DMI72_10460	COG0789	Transcriptional regulator
DMI72_10475	COG0534	Mate efflux family protein
DMI72_10505	COG1091	dTDP-4-dehydrorhamnose reductase activity
DMI72_10520	COG1837	Belongs to the UPF0109 family
DMI72_10530	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
DMI72_10535	COG0363	glucosamine-6-phosphate deaminase activity
DMI72_10560	COG1741	Belongs to the pirin family
DMI72_10580	COG1070	Carbohydrate kinase
DMI72_10595	COG0738	Major facilitator superfamily
DMI72_10610	COG1595	DNA-templated transcription, initiation
DMI72_10630	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
DMI72_10650	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DMI72_10660	COG0232	Belongs to the dGTPase family. Type 2 subfamily
DMI72_10665	COG2132	Multicopper oxidase
DMI72_10670	COG0697	spore germination
DMI72_10675	COG3586	endonuclease activity
DMI72_10690	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
DMI72_10695	COG4608	Belongs to the ABC transporter superfamily
DMI72_10700	COG0444	Belongs to the ABC transporter superfamily
DMI72_10705	COG4166	transmembrane transport
DMI72_10710	COG4239	(ABC) transporter, permease
DMI72_10715	COG0601	transmembrane transport
DMI72_10735	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
DMI72_10740	COG2759	Belongs to the formate--tetrahydrofolate ligase family
DMI72_10745	COG3738	Protein conserved in bacteria
DMI72_10750	COG0151	Belongs to the GarS family
DMI72_10765	COG0811	peptide transport
DMI72_10775	COG0242	peptide deformylase activity
DMI72_10815	COG2010	Cytochrome c
DMI72_10825	COG3258	Cytochrome c
DMI72_10840	COG3274	enterobacterial common antigen metabolic process
DMI72_10845	COG0538	isocitrate dehydrogenase activity
DMI72_10865	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
DMI72_10870	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
DMI72_10875	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
DMI72_10885	COG0668	transmembrane transport
DMI72_10890	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
DMI72_10890	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DMI72_10895	COG0805	protein transport
DMI72_10900	COG1968	undecaprenyl-diphosphatase activity
DMI72_10905	COG1968	undecaprenyl-diphosphatase activity
DMI72_10925	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
DMI72_10935	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
DMI72_10945	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
DMI72_10955	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
DMI72_10965	COG1408	metallophosphoesterase
DMI72_10990	COG4974	Belongs to the 'phage' integrase family
DMI72_11010	COG1454	alcohol dehydrogenase
DMI72_11015	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
DMI72_11025	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
DMI72_11025	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
DMI72_11030	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
DMI72_11070	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
DMI72_11080	COG4607	ABC-type enterochelin transport system periplasmic component
DMI72_11085	COG4604	ABC transporter, ATP-binding protein
DMI72_11090	COG4605	iron ion homeostasis
DMI72_11095	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DMI72_11130	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DMI72_11130	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DMI72_11145	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
DMI72_11155	COG2195	Cleaves the N-terminal amino acid of tripeptides
DMI72_11175	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DMI72_11195	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
DMI72_11220	COG0518	GMP synthase (glutamine-hydrolyzing) activity
DMI72_11220	COG0519	Catalyzes the synthesis of GMP from XMP
DMI72_11225	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
DMI72_11265	COG1410	methionine synthase
DMI72_11265	COG0646	methionine synthase
DMI72_11270	COG2966	Psort location CytoplasmicMembrane, score
DMI72_11275	COG3610	response to peptide
DMI72_11285	COG0460	homoserine dehydrogenase
DMI72_11290	COG0527	aspartate kinase activity
DMI72_11300	COG5522	Integral membrane protein (intg_mem_TP0381)
DMI72_11315	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DMI72_11325	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
DMI72_11330	COG1194	a g-specific adenine glycosylase
DMI72_11335	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
DMI72_11340	COG0574	Belongs to the PEP-utilizing enzyme family
DMI72_11340	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DMI72_11350	COG0166	Belongs to the GPI family
DMI72_11360	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
DMI72_11380	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
DMI72_11380	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
DMI72_11415	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
DMI72_11420	COG2818	Glycosylase
DMI72_11440	COG3033	Beta-eliminating lyase
DMI72_11455	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DMI72_11455	COG0072	phenylalanine-tRNA ligase activity
DMI72_11470	COG3059	membrane
DMI72_11480	COG0326	Molecular chaperone. Has ATPase activity
DMI72_11505	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
DMI72_11510	COG1959	2 iron, 2 sulfur cluster binding
DMI72_11525	COG0352	thiamine-phosphate diphosphorylase activity
DMI72_11530	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
DMI72_11545	COG3525	Glycosyl hydrolase, family 20, catalytic domain
DMI72_11555	COG1703	isobutyryl-CoA mutase activity
DMI72_11575	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
DMI72_11585	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DMI72_11590	COG0418	dihydroorotase activity
DMI72_11605	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DMI72_11625	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DMI72_11655	COG0534	Mate efflux family protein
DMI72_11660	COG0489	protein tyrosine kinase activity
DMI72_11675	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DMI72_11685	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DMI72_11695	COG1538	Outer membrane efflux protein
DMI72_11715	COG4112	unkown
DMI72_11735	COG0038	chloride channel
DMI72_11760	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
DMI72_11770	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
DMI72_11775	COG0586	Pfam SNARE associated Golgi protein
DMI72_11845	COG1012	belongs to the aldehyde dehydrogenase family
DMI72_11865	COG0753	catalase activity
DMI72_11875	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
DMI72_11880	COG1592	Rubrerythrin
DMI72_11885	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DMI72_11905	COG0489	protein tyrosine kinase activity
DMI72_11915	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
DMI72_11925	COG2244	polysaccharide biosynthetic process
DMI72_11930	COG1216	Glycosyl transferase, family 2
DMI72_11940	COG1216	Glycosyl transferase, family 2
DMI72_11950	COG0438	transferase activity, transferring glycosyl groups
DMI72_11955	COG0438	transferase activity, transferring glycosyl groups
DMI72_11985	COG1216	Glycosyl transferase, family 2
DMI72_12030	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
DMI72_12040	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DMI72_12045	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
DMI72_12060	COG0281	malic enzyme
DMI72_12060	COG0280	phosphate acetyltransferase
DMI72_12075	COG1472	Belongs to the glycosyl hydrolase 3 family
DMI72_12080	COG1472	Belongs to the glycosyl hydrolase 3 family
DMI72_12085	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
DMI72_12100	COG0635	Involved in the biosynthesis of porphyrin-containing compound
DMI72_12110	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
DMI72_12115	COG1063	alcohol dehydrogenase
DMI72_12130	COG0714	Associated with various cellular activities
DMI72_12140	COG0193	aminoacyl-tRNA hydrolase activity
DMI72_12145	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DMI72_12160	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
DMI72_12185	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
DMI72_12200	COG0375	protein maturation
DMI72_12225	COG0778	Nitroreductase
DMI72_12230	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DMI72_12245	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DMI72_12245	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DMI72_12260	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
DMI72_12260	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
DMI72_12280	COG3525	Glycosyl hydrolase, family 20, catalytic domain
DMI72_12285	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
DMI72_12290	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
DMI72_12335	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DMI72_12340	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DMI72_12355	COG0318	PFAM AMP-dependent synthetase and ligase
DMI72_12385	COG0339	signal peptide processing
DMI72_12395	COG0018	arginyl-trna synthetase
DMI72_12430	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
DMI72_12435	COG0653	protein targeting
DMI72_12450	COG0494	nUDIX hydrolase