locus-tag	class	description
C5O14_00005	ENOG4105CI4	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity)
C5O14_00010	ENOG4105CJ1	ABC, transporter
C5O14_00030	ENOG4107XF7	NGG1p interacting factor 3 protein, NIF3
C5O14_00050	ENOG4105C77	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity)
C5O14_00055	ENOG4105BZQ	cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase
C5O14_00065	ENOG4105C1J	atp-dependent rna helicase
C5O14_00085	ENOG4105EPC	oxidoreductase
C5O14_00105	ENOG4105DTW	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
C5O14_00115	ENOG4105JAB	phenazine biosynthesis protein, phzf family
C5O14_00120	ENOG4108UI1	Probably functions as a manganese efflux pump (By similarity)
C5O14_00150	ENOG4108IAJ	Nad-dependent epimerase dehydratase
C5O14_00175	ENOG4107QP0	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity)
C5O14_00220	ENOG4105E5D	amino acid
C5O14_00225	ENOG4105CSV	Glutaminase
C5O14_00240	ENOG4105BZG	amino acid carrier protein
C5O14_00250	ENOG4105C8K	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity)
C5O14_00255	ENOG4105EQY	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity)
C5O14_00260	ENOG4105C25	Primosomal protein n'
C5O14_00265	ENOG4105E4Z	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity)
C5O14_00285	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
C5O14_00290	ENOG4107QJQ	Mate efflux family protein
C5O14_00335	ENOG4105CYQ	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity)
C5O14_00340	ENOG4105C2R	Single-stranded-DNA-specific exonuclease (RecJ)
C5O14_00345	ENOG4105CPE	K01197 hyaluronoglucosaminidase EC 3.2.1.35
C5O14_00360	ENOG4105DIK	(ABC) transporter
C5O14_00365	ENOG4105CC5	ABC transporter
C5O14_00370	ENOG4108Z0C	Uvrb UvrC protein
C5O14_00375	ENOG41066A3	ATP guanido phosphotransferase
C5O14_00380	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
C5O14_00390	ENOG4105M78	Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity)
C5O14_00395	ENOG4105ERH	Fumarylacetoacetate hydrolase
C5O14_00400	ENOG4105CYQ	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity)
C5O14_00415	ENOG4108UH8	Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity)
C5O14_00425	ENOG4105C31	Tryptophanyl-tRNA synthetase
C5O14_00435	ENOG4105D48	metallophosphoesterase
C5O14_00445	ENOG4105CUZ	uba thif-type nad fad binding protein
C5O14_00615	ENOG4105D7K	pfkb domain protein
C5O14_00625	ENOG4105E09	nadh pyrophosphatase
C5O14_00640	ENOG4107EEK	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity)
C5O14_00655	ENOG4107WDG	serine threonine protein kinase
C5O14_00695	ENOG4105DC6	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity)
C5O14_00705	ENOG4105K78	MarR family Transcriptional regulator
C5O14_00715	ENOG4105D6W	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity)
C5O14_00720	ENOG4105C7E	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity)
C5O14_00730	ENOG4105DZA	Converts GTP to 7,8-dihydroneopterin triphosphate (By similarity)
C5O14_00735	ENOG4105VH8	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity)
C5O14_00740	ENOG41083ND	50S ribosomal protein L33
C5O14_00745	ENOG4105SCY	DNAK suppressor
C5O14_00750	ENOG4105DKQ	ROK family
C5O14_00755	ENOG4105CYJ	ribosomal RNA small subunit methyltransferase B
C5O14_00765	ENOG4105M6F	mutator MutT protein
C5O14_00770	ENOG4105CW7	secretion protein, HlyD family
C5O14_00775	ENOG4108EE5	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
C5O14_00780	ENOG4108EE5	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
C5O14_00785	ENOG4105ENJ	RND efflux system, outer membrane lipoprotein
C5O14_00800	ENOG4105C1P	efflux transporter, rnd family, mfp subunit
C5O14_00845	ENOG4108R96	Methyltransferase, YaeB family
C5O14_00850	ENOG4105CD3	dihydroorotase
C5O14_00855	ENOG4105CXT	aspartate transcarbamylase
C5O14_00860	ENOG4108UK1	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity)
C5O14_00875	ENOG4105DZ0	fad dependent oxidoreductase
C5O14_00880	ENOG4105DWY	Agmatine deiminase
C5O14_00890	ENOG4105DZP	Membrane-associated zinc metalloprotease
C5O14_00900	ENOG41061MV	Arylsulfatase
C5O14_00910	ENOG4105CE1	Ferrous iron transport protein b
C5O14_00935	ENOG4105DF5	DNA topoisomerase IV, subunit A
C5O14_00970	ENOG4105FA0	parb-like partition protein
C5O14_01000	ENOG4105DHU	Bile acid
C5O14_01005	ENOG4105DA0	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity)
C5O14_01025	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
C5O14_01030	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
C5O14_01035	ENOG4107QSI	ABC, transporter
C5O14_01075	ENOG4105CDK	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity)
C5O14_01080	ENOG4105CIT	This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity)
C5O14_01095	ENOG4105BZ1	(ABC) transporter
C5O14_01100	ENOG4105BZ1	(ABC) transporter
C5O14_01115	ENOG4105DHJ	ABC, transporter
C5O14_01120	ENOG4107PE3	Mammalian cell entry related domain protein
C5O14_01145	ENOG4105CZX	twitching motility protein
C5O14_01150	ENOG4105CZX	twitching motility protein
C5O14_01155	ENOG4105DBD	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity)
C5O14_01170	ENOG4105CET	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity)
C5O14_01175	ENOG4105C8D	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity)
C5O14_01180	ENOG4107RJ1	sodium solute
C5O14_01215	ENOG4108JQC	penicillin-binding protein 1A
C5O14_01225	ENOG4108VXP	Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity)
C5O14_01230	ENOG4105DAF	Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
C5O14_01240	ENOG4105D60	lipoprotein releasing system transmembrane protein
C5O14_01240	ENOG4105D60	lipoprotein releasing system transmembrane protein
C5O14_01285	ENOG4107VAM	peptidase, m28
C5O14_01295	ENOG4105C07	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity)
C5O14_01300	ENOG4105M02	This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity)
C5O14_01315	ENOG4105C9B	Cysteine desulfurase
C5O14_01325	ENOG4106PBJ	Serine threonine-protein kinase Pkn6
C5O14_01335	ENOG4108YY1	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity)
C5O14_01345	ENOG4108ZVT	methylmalonyl-coA epimerase
C5O14_01350	ENOG4107QX3	carboxylase
C5O14_01360	ENOG4108JIJ	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity)
C5O14_01365	ENOG4105D9Q	decarboxylase (Beta subunit)
C5O14_01370	ENOG4105HJX	Biotin- acetyl-CoA-carboxylase ligase
C5O14_01375	ENOG4105CYC	Transferase
C5O14_01390	ENOG4108I19	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity)
C5O14_01395	ENOG4105C1B	dTDP-glucose 4-6-dehydratase
C5O14_01400	ENOG4105CTQ	phosphohexokinase
C5O14_01415	ENOG4105CHT	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
C5O14_01420	ENOG4105C7K	acetolactate synthase
C5O14_01440	ENOG4105C52	Atpase, p-type (Transporting), had superfamily, subfamily ic
C5O14_01445	ENOG4105C1P	efflux transporter, rnd family, mfp subunit
C5O14_01455	ENOG4105C8P	)-transporter
C5O14_01530	ENOG4108Z02	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity)
C5O14_01535	ENOG4105CPQ	Dehydrogenase
C5O14_01545	ENOG4105EYW	Ion transport protein
C5O14_01550	ENOG41080E8	Transcriptional regulator, Spx MgsR family
C5O14_01555	ENOG4105CY0	Metallo-Beta-Lactamase
C5O14_01575	ENOG4105FE9	pseudouridine synthase
C5O14_01585	ENOG4105D6X	Specifically methylates guanosine-37 in various tRNAs (By similarity)
C5O14_01590	ENOG4105CG1	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity)
C5O14_01600	ENOG4105CAV	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity)
C5O14_01655	ENOG4105CCG	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity)
C5O14_01660	ENOG4105K8U	2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
C5O14_01665	ENOG4105DUK	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity)
C5O14_01670	ENOG4105CDP	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity)
C5O14_01710	ENOG4105KJP	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
C5O14_01735	ENOG4108Z2K	Cupin 2, conserved barrel domain protein
C5O14_01745	ENOG4105C6B	Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity)
C5O14_01765	ENOG4105EK0	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
C5O14_01770	ENOG4105KHV	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity)
C5O14_01775	ENOG4105K5M	30s ribosomal protein S16
C5O14_01805	ENOG4105VIE	preprotein translocase, subunit YajC
C5O14_01815	ENOG4105CZ1	Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity)
C5O14_01825	ENOG4105K6T	rare lipoprotein A
C5O14_01830	ENOG4107FSS	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
C5O14_01835	ENOG41080YA	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity)
C5O14_01885	ENOG4105CNT	hydrolase family 2
C5O14_01890	ENOG4105CA4	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity)
C5O14_01905	ENOG4108UNN	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity)
C5O14_01910	ENOG4105K87	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal
C5O14_01915	ENOG41082SA	50s ribosomal protein l29
C5O14_01920	ENOG4108R70	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity)
C5O14_01925	ENOG4105CKE	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity)
C5O14_01930	ENOG41080P9	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity)
C5O14_01940	ENOG4105K7S	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity)
C5O14_01945	ENOG4105CFD	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
C5O14_01950	ENOG4108542	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity)
C5O14_01955	ENOG4106U5A	One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity)
C5O14_01960	ENOG4105EEE	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity)
C5O14_01965	ENOG4108Z10	Involved in the binding of tRNA to the ribosomes (By similarity)
C5O14_01970	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
C5O14_01975	ENOG4108UHY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity)
C5O14_01980	ENOG4108UKE	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity)
C5O14_01990	ENOG4105CJI	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
C5O14_02000	ENOG4105BZU	Histidine kinase
C5O14_02005	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
C5O14_02020	ENOG4105C2V	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity)
C5O14_02035	ENOG4108M8S	permease YjgP YjgQ family protein
C5O14_02040	ENOG4105DKZ	GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity)
C5O14_02060	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
C5O14_02070	ENOG4105CSF	NADPH-dependent glycerol-3-phosphate dehydrogenase
C5O14_02100	ENOG4105CSG	Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity)
C5O14_02115	ENOG4105D86	that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity)
C5O14_02125	ENOG4105KEM	Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity)
C5O14_02130	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
C5O14_02145	ENOG4108IPT	Naphthoate synthase
C5O14_02185	ENOG4107T0D	ABC, transporter
C5O14_02200	ENOG4108IJ6	ABC transporter
C5O14_02210	ENOG4105EMU	Dehydrogenase
C5O14_02225	ENOG4108JUA	Transcriptional regulator
C5O14_02240	ENOG4105E2D	ec 3.2.1.52
C5O14_02255	ENOG4105CVK	Glutamate decarboxylase
C5O14_02265	ENOG4105C0B	DNA polymerase III (alpha subunit)
C5O14_02270	ENOG4107QYT	Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity)
C5O14_02275	ENOG4108UV6	Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity)
C5O14_02295	ENOG4105C37	(CBS) domain
C5O14_02300	ENOG4105C37	(CBS) domain
C5O14_02305	ENOG4105C62	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity)
C5O14_02310	ENOG4105K77	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity)
C5O14_02345	ENOG4105DI7	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity)
C5O14_02350	ENOG4108Z1W	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity)
C5O14_02365	ENOG4106855	Competence protein
C5O14_02380	ENOG4105E2D	ec 3.2.1.52
C5O14_02385	ENOG4105E78	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity)
C5O14_02400	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
C5O14_02405	ENOG4107QQT	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity)
C5O14_02415	ENOG4105D7M	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
C5O14_02440	ENOG4105CPE	K01197 hyaluronoglucosaminidase EC 3.2.1.35
C5O14_02450	ENOG4108ZI0	d,d-heptose 1,7-bisphosphate phosphatase
C5O14_02455	ENOG4105F55	Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity)
C5O14_02460	ENOG4105DW0	Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity)
C5O14_02465	ENOG4108775	30S ribosomal protein S21
C5O14_02470	ENOG4105CDM	Glutamate-1-semialdehyde aminotransferase
C5O14_02485	ENOG4107QNK	)-transporter
C5O14_02495	ENOG4105CX6	glutaminyL-tRNA synthetase
C5O14_02500	ENOG4105C66	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity)
C5O14_02505	ENOG4108UTT	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity)
C5O14_02510	ENOG410803B	Involved in the transcription termination process (By similarity)
C5O14_02515	ENOG4105CCP	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)
C5O14_02520	ENOG4105C55	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs
C5O14_02525	ENOG4105CDU	Replicative dna helicase
C5O14_02540	ENOG4105CEV	competence damage-inducible protein
C5O14_02550	ENOG4108W0I	acetyltransferase
C5O14_02575	ENOG4105G6W	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity)
C5O14_02580	ENOG4108UHH	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity)
C5O14_02585	ENOG4108Z04	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
C5O14_02590	ENOG4105EH2	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity)
C5O14_02605	ENOG4105C79	DNA protecting protein DprA
C5O14_02610	ENOG4105DZ1	carboxypeptidase
C5O14_02615	ENOG4105C3G	gtp-binding protein
C5O14_02630	ENOG4105CBI	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C5O14_02645	ENOG41061MV	Arylsulfatase
C5O14_02675	ENOG4105NQG	DoxX
C5O14_02680	ENOG4105CXB	phosphoribosylaminoimidazole synthetase
C5O14_02685	ENOG4105CBA	glutamine phosphoribosylpyrophosphate amidotransferase
C5O14_02690	ENOG4105EMN	RNA polymerase sigma factor
C5O14_02710	ENOG4105CJS	Phosphopantothenoylcysteine decarboxylase
C5O14_02730	ENOG4105CSR	polyphosphate kinase 2
C5O14_02735	ENOG4107EDW	L-fucose operon activator
C5O14_02750	ENOG4105C3J	Cysteine desulfurase
C5O14_02755	ENOG4105C3J	Cysteine desulfurase
C5O14_02760	ENOG4105CJS	Phosphopantothenoylcysteine decarboxylase
C5O14_02765	ENOG4105E06	May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity)
C5O14_02780	ENOG4106H78	methyltransferase
C5O14_02795	ENOG4105CSR	polyphosphate kinase 2
C5O14_02805	ENOG41084I7	Alpha-galactosidase. Removes both branched alpha-1,3- linked galactose residues of blood group B antigens and linear alpha-1,3-linked galactose structures
C5O14_02815	ENOG4107XM9	(LipO)protein
C5O14_02820	ENOG4105K8N	protein family UPF0079, ATPase
C5O14_02830	ENOG4105K46	50S ribosomal protein l27
C5O14_02835	ENOG4105G5W	regulator Fur family
C5O14_02840	ENOG4105C3K	feS assembly ATPase SufC
C5O14_02845	ENOG4105DIW	FeS assembly protein SUFB
C5O14_02850	ENOG4105JRK	feS assembly protein SufD
C5O14_02860	ENOG4107QRH	Arylsulfatase (Ec 3.1.6.1)
C5O14_02865	ENOG4105CZF	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity)
C5O14_02910	ENOG4105CF4	DegT DnrJ EryC1 StrS aminotransferase
C5O14_02930	ENOG4105KNM	Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity)
C5O14_02935	ENOG4105C4J	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity)
C5O14_02940	ENOG4105J80	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity)
C5O14_02945	ENOG4105CDG	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity)
C5O14_02950	ENOG4107S15	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
C5O14_02965	ENOG4105EE4	it plays a direct role in the translocation of protons across the membrane (By similarity)
C5O14_02975	ENOG4105CJN	penicillin-binding protein
C5O14_03020	ENOG4105D06	uba thif-type nad fad binding protein
C5O14_03025	ENOG4105C2X	Arabinose 5-phosphate isomerase
C5O14_03045	ENOG4105D7W	serine acetyltransferase
C5O14_03055	ENOG4105C2S	Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity)
C5O14_03060	ENOG4105CGT	Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity)
C5O14_03065	ENOG4105CV1	Transketolase (EC 2.2.1.1)
C5O14_03075	ENOG4107QPR	SAICAR synthetase
C5O14_03085	ENOG4108JIU	phosphoribosylformylglycinamidine synthase ii
C5O14_03090	ENOG4105D21	Phosphoribosylformylglycinamidine synthase I
C5O14_03100	ENOG4105CN9	Peptidase m42 family protein
C5O14_03120	ENOG4105C03	ribonuclease
C5O14_03145	ENOG4109015	Biopolymer transport protein exbD tolR
C5O14_03160	ENOG4105CSM	endonuclease III
C5O14_03185	ENOG4105DK0	Indole-3-glycerol phosphate synthase
C5O14_03190	ENOG41080R2	UPF0102 protein
C5O14_03200	ENOG4105C37	(CBS) domain
C5O14_03210	ENOG41082R9	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity)
C5O14_03220	ENOG4105CDH	Citrulline--aspartate ligase
C5O14_03225	ENOG4107QRH	Arylsulfatase (Ec 3.1.6.1)
C5O14_03235	ENOG4105CP7	Triose-phosphate isomerase
C5O14_03250	ENOG4107QRH	Arylsulfatase (Ec 3.1.6.1)
C5O14_03270	ENOG41081UC	Inherit from COG: Competence protein
C5O14_03280	ENOG4105DXN	mazG family
C5O14_03305	ENOG4105CHD	Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity)
C5O14_03315	ENOG4107RAN	Peptidase, M16
C5O14_03335	ENOG4105WPN	DNA integration recombination invertion protein
C5O14_03340	ENOG4107R11	Transcriptional regulator
C5O14_03345	ENOG4105SYT	Methylenetetrahydrofolate reductase
C5O14_03370	ENOG4105DGA	Diaminopimelate dehydrogenase
C5O14_03375	ENOG4105F7V	ErfK ybiS ycfS ynhG family protein
C5O14_03400	ENOG4105C7B	Threonine dehydratase
C5O14_03405	ENOG4108Z03	MAF-like protein
C5O14_03410	ENOG4105C1N	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity)
C5O14_03430	ENOG4105CG2	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity)
C5O14_03440	ENOG4105CAT	Cytidine monophosphate kinase
C5O14_03450	ENOG4105C3X	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity)
C5O14_03460	ENOG4108ZBM	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity)
C5O14_03475	ENOG4105CGK	Exodeoxyribonuclease III
C5O14_03480	ENOG4105CU0	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity)
C5O14_03495	ENOG4105K8F	Phosphoribosyl-amp cyclohydrolase
C5O14_03500	ENOG4107QRG	dna polymerase iii
C5O14_03535	ENOG4108WVK	Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity)
C5O14_03585	ENOG4105CKJ	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity)
C5O14_03590	ENOG4105CCZ	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity)
C5O14_03595	ENOG4107EER	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity)
C5O14_03600	ENOG4105K64	Glycosyl transferase, family 2
C5O14_03605	ENOG4105K64	Glycosyl transferase, family 2
C5O14_03630	ENOG4107TAE	Glycosyl transferase (Group 1
C5O14_03650	ENOG4105DKX	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity)
C5O14_03660	ENOG4105CCJ	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity)
C5O14_03665	ENOG4105C1H	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity)
C5O14_03675	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
C5O14_03695	ENOG4105HD0	Transcriptional regulator of molybdate metabolism, LysR family
C5O14_03765	ENOG4105EN6	Membrane
C5O14_03770	ENOG4105CY0	Metallo-Beta-Lactamase
C5O14_03775	ENOG4108V6E	Cell division protein mraZ
C5O14_03780	ENOG4105CGJ	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity)
C5O14_03790	ENOG4105CJN	penicillin-binding protein
C5O14_03795	ENOG4107EEN	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity)
C5O14_03800	ENOG4107EES	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity)
C5O14_03805	ENOG4105CPY	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity)
C5O14_03810	ENOG4105DMZ	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity)
C5O14_03820	ENOG4105CNI	cell division protein FtsW
C5O14_03825	ENOG4105DVQ	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity)
C5O14_03830	ENOG4105DFU	Cell wall formation (By similarity)
C5O14_03835	ENOG4105CPF	Cell wall formation (By similarity)
C5O14_03845	ENOG4105C68	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity)
C5O14_03850	ENOG4108KNB	n-acetylmuramoyl-l-alanine amidase
C5O14_03855	ENOG4108BDP	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity)
C5O14_03860	ENOG4105CQI	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
C5O14_03865	ENOG4105MQS	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
C5O14_03875	ENOG4105C0H	protease
C5O14_03885	ENOG4105D49	3-dehydroquinate synthase
C5O14_03895	ENOG4108JQ7	(ABC) transporter
C5O14_03905	ENOG4105CU7	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity)
C5O14_03910	ENOG4105CE9	30S ribosomal protein S2
C5O14_03920	ENOG4105CXR	Phospho-2-dehydro-3-deoxyoctonate aldolase
C5O14_03935	ENOG4108IUZ	ABC transporter
C5O14_03945	ENOG4105DFU	Cell wall formation (By similarity)
C5O14_03950	ENOG4105UYK	outer membrane protein a
C5O14_03960	ENOG4105KVH	Transcriptional regulator
C5O14_03970	ENOG4105C5U	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity)
C5O14_04010	ENOG4105C5S	asparaginyl-tRNA synthetase
C5O14_04020	ENOG4105K63	Thioredoxin
C5O14_04070	ENOG4105HMI	Membrane
C5O14_04075	ENOG4107STF	Involved in phosphonate degradation (By similarity)
C5O14_04100	ENOG4105EIZ	Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity)
C5O14_04105	ENOG4105C4P	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity)
C5O14_04110	ENOG4105CDY	transcriptional regulatory protein
C5O14_04120	ENOG4105CKD	glutathione-regulated potassium-efflux system protein
C5O14_04130	ENOG4105E2N	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity)
C5O14_04135	ENOG4105DI5	UPF0365 protein
C5O14_04145	ENOG4105CA8	Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity)
C5O14_04150	ENOG4107RY6	amino acid
C5O14_04160	ENOG4105DSF	transport protein
C5O14_04165	ENOG4105CU5	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity)
C5O14_04170	ENOG4107RCW	fructose-bisphosphate aldolase
C5O14_04175	ENOG4105CI3	gtp-binding protein typa
C5O14_04180	ENOG4105CM2	brancheD-chain amino acid aminotransferase
C5O14_04210	ENOG4105C9R	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
C5O14_04250	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
C5O14_04255	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
C5O14_04260	ENOG4105ESI	atpase involved in dna repair
C5O14_04270	ENOG4108VXP	Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity)
C5O14_04295	ENOG4105E99	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity)
C5O14_04300	ENOG4105X0D	Fimbrial protein
C5O14_04310	ENOG4108Z2X	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity)
C5O14_04320	ENOG4105D0T	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity)
C5O14_04330	ENOG4105DIN	metallophosphoesterase
C5O14_04350	ENOG4105CUI	Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity)
C5O14_04355	ENOG4105K64	Glycosyl transferase, family 2
C5O14_04375	ENOG4105EXC	Acyl-transferase
C5O14_04390	ENOG4107QWE	)-transporter
C5O14_04430	ENOG4105DKJ	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
C5O14_04435	ENOG4105C5I	Dehydrogenase
C5O14_04445	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
C5O14_04450	ENOG4105NAU	thioesterase Superfamily protein
C5O14_04460	ENOG4105CYX	Short-chain dehydrogenase reductase Sdr
C5O14_04470	ENOG4105KK6	nuclease
C5O14_04485	ENOG4105GTN	ParB Domain Protein Nuclease
C5O14_04490	ENOG4105BZV	Phosphoadenosine phosphosulfate reductase
C5O14_04505	ENOG4105C0C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity)
C5O14_04520	ENOG4105C0P	Mg chelatase subunit ChlI
C5O14_04540	ENOG4105EZY	Pyrroloquinoline quinone biosynthesis protein E
C5O14_04555	ENOG4105CSF	NADPH-dependent glycerol-3-phosphate dehydrogenase
C5O14_04560	ENOG4105K7Z	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity)
C5O14_04570	ENOG4105CRK	lysyL-tRNA synthetase
C5O14_04585	ENOG4105KVH	Transcriptional regulator
C5O14_04595	ENOG4105C0S	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity)
C5O14_04615	ENOG4105CQ7	ATP-dependent helicase
C5O14_04620	ENOG4108ZP8	Acetolactate synthase small subunit
C5O14_04625	ENOG4105C0H	protease
C5O14_04635	ENOG4107RE5	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity)
C5O14_04640	ENOG4105D1W	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity)
C5O14_04645	ENOG4105CZ8	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity)
C5O14_04675	ENOG4105F8V	Hydrolase, tatD family
C5O14_04685	ENOG4105CNT	hydrolase family 2
C5O14_04700	ENOG4105C08	Histidine kinase
C5O14_04705	ENOG4105EEX	Two component transcriptional regulator (Winged helix family
C5O14_04720	ENOG4105D9K	One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity)
C5O14_04725	ENOG4105C8X	One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity)
C5O14_04730	ENOG4108R80	One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity)
C5O14_04745	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
C5O14_04795	ENOG4108Z11	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity)
C5O14_04805	ENOG4105CHH	sulfate transporter
C5O14_04810	ENOG4105CH7	arginosuccinase
C5O14_04825	ENOG4105C70	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity)
C5O14_04830	ENOG4105EFU	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity)
C5O14_04845	ENOG4105EQI	Metal Dependent Phosphohydrolase
C5O14_04855	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
C5O14_04860	ENOG4105BZT	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity)
C5O14_04910	ENOG4105DME	alpha-galactosidase
C5O14_04930	ENOG4105D0C	transport protein
C5O14_04945	ENOG4105C8P	)-transporter
C5O14_04975	ENOG4108RAC	Rubrerythrin
C5O14_04985	ENOG4105CN9	Peptidase m42 family protein
C5O14_04990	ENOG4105E2D	ec 3.2.1.52
C5O14_05000	ENOG4105G6Z	alkaline phosphatase
C5O14_05005	ENOG4105M2E	Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity)
C5O14_05010	ENOG4105C8Y	Acetylornithine aminotransferase
C5O14_05030	ENOG4105C59	p-type ATPase
C5O14_05035	ENOG4105C4F	May be involved in recombinational repair of damaged DNA (By similarity)
C5O14_05040	ENOG4108H5C	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity)
C5O14_05045	ENOG4108UHC	Glycosyl transferase, wecb taga cpsf family
C5O14_05080	ENOG4105CPP	Dehydrogenase, E1 component
C5O14_05085	ENOG4105C2V	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity)
C5O14_05100	ENOG4105C1P	efflux transporter, rnd family, mfp subunit
C5O14_05140	ENOG4105C9U	ATP-dependent DNA helicase RecQ
C5O14_05160	ENOG4108VPC	n-acetylmuramoyl-l-alanine amidase
C5O14_05165	ENOG4107QM5	aconitate hydratase
C5O14_05195	ENOG4105E0Y	RtcB Protein
C5O14_05205	ENOG4105CZM	Major Facilitator
C5O14_05215	ENOG4108WBT	adenosyltransferase
C5O14_05225	ENOG4105C40	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity)
C5O14_05250	ENOG4105CFP	Peptidase U32
C5O14_05255	ENOG4105DPM	folylpolyglutamate synthase Dihydrofolate synthase
C5O14_05270	ENOG410823G	oxidoreductase
C5O14_05275	ENOG4105C0D	helicase
C5O14_05285	ENOG4105CGH	5'-nucleotidase
C5O14_05290	ENOG4105K6T	rare lipoprotein A
C5O14_05295	ENOG4105F91	Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity)
C5O14_05300	ENOG4105F91	Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity)
C5O14_05305	ENOG41082A0	One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity)
C5O14_05320	ENOG4108R5J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity)
C5O14_05325	ENOG4105K4C	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity)
C5O14_05330	ENOG4108RA9	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity)
C5O14_05335	ENOG4108UZ0	Binds to the 23S rRNA (By similarity)
C5O14_05340	ENOG4105CGG	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity)
C5O14_05345	ENOG4105CC8	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity)
C5O14_05350	ENOG4105CA1	Removes the N-terminal methionine from nascent proteins (By similarity)
C5O14_05365	ENOG4105CUU	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity)
C5O14_05380	ENOG4105K64	Glycosyl transferase, family 2
C5O14_05390	ENOG4105K64	Glycosyl transferase, family 2
C5O14_05405	ENOG4105K64	Glycosyl transferase, family 2
C5O14_05410	ENOG4108Z0Z	intracellular protease Pfpi family
C5O14_05415	ENOG4105C7S	Dehydrogenase
C5O14_05420	ENOG4105CE4	GlcNAc 6-P deacetylase
C5O14_05425	ENOG4107XH4	PPIases accelerate the folding of proteins (By similarity)
C5O14_05445	ENOG4105ENH	Sulfatase
C5O14_05450	ENOG41084NN	Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity)
C5O14_05455	ENOG4107EEM	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity)
C5O14_05460	ENOG4105CHV	Transcription elongation factor NusA
C5O14_05465	ENOG4105CGK	Exodeoxyribonuclease III
C5O14_05470	ENOG4108V82	Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity)
C5O14_05490	ENOG4105IDI	abc transporter atp-binding protein
C5O14_05515	ENOG4105VFU	Rna-binding protein
C5O14_05520	ENOG4105D3Q	Sugar transferase
C5O14_05540	ENOG4105CAE	Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity)
C5O14_05550	ENOG4105CGM	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity)
C5O14_05555	ENOG4105VNB	Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity)
C5O14_05570	ENOG4108YYA	Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity)
C5O14_05585	ENOG4105E33	succinate dehydrogenase
C5O14_05640	ENOG4105CHR	reductase
C5O14_05650	ENOG4105C5H	ABC transporter
C5O14_05660	ENOG4105MS2	ribosomal subunit Interface protein
C5O14_05675	ENOG4107EXU	Short-chain dehydrogenase reductase Sdr
C5O14_05685	ENOG4105ENX	hydrolase
C5O14_05695	ENOG4105CPC	Aldo Keto reductase
C5O14_05715	ENOG4105DY9	regulatoR
C5O14_05750	ENOG4105D3C	The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity)
C5O14_05755	ENOG41076UM	multiple antibiotic resistance (MarC)-related protein
C5O14_05785	ENOG4107XH4	PPIases accelerate the folding of proteins (By similarity)
C5O14_05790	ENOG4105C5H	ABC transporter
C5O14_05865	ENOG4105C8N	cysteinyl-tRNA synthetase
C5O14_05870	ENOG4105E2D	ec 3.2.1.52
C5O14_05875	ENOG4105CBG	Sulfatase
C5O14_05885	ENOG4105C4S	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity)
C5O14_05915	ENOG4107QR0	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
C5O14_05920	ENOG4107QIH	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
C5O14_05925	ENOG4105KBC	Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity)
C5O14_05930	ENOG4107Z3D	50S ribosomal protein l10
C5O14_05935	ENOG4105C64	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity)
C5O14_05940	ENOG4108UIK	This protein binds directly to 23S ribosomal RNA (By similarity)
C5O14_05945	ENOG4105E5V	Participates in transcription elongation, termination and antitermination (By similarity)
C5O14_05960	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
C5O14_05970	ENOG4105CPM	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
C5O14_05980	ENOG4105CCQ	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity)
C5O14_05985	ENOG4105DEA	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation
C5O14_05990	ENOG4105E1Z	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C5O14_06000	ENOG4105SYT	Methylenetetrahydrofolate reductase
C5O14_06020	ENOG4108IJF	Heavy metal efflux pump, CzcA
C5O14_06065	ENOG4105DA6	Catalyzes the conversion of 5-methoxyuridine (mo5U) to uridine-5-oxyacetic acid (cmo5U) at position 34 in tRNA. May also participate in the methylation of uridine-5-oxyacetic acid (cmo5U) to uridine-5-oxyacetic acid methyl ester (mcmo5U) (By similarity)
C5O14_06070	ENOG4105CPH	Catalyzes the formation of S-adenosylmethionine from methionine and ATP
C5O14_06075	ENOG4105C3E	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity)
C5O14_06100	ENOG4105CBG	Sulfatase
C5O14_06105	ENOG4105C9U	ATP-dependent DNA helicase RecQ
C5O14_06120	ENOG4107XB0	Lipopolysaccharide 1,2-N-acetylglucosaminetransferase
C5O14_06130	ENOG4108IYU	L-aspartate oxidase
C5O14_06135	ENOG4105C2N	RNA methyltransferase TrmH family group 3
C5O14_06200	ENOG4105CA0	peroxidase
C5O14_06205	ENOG4105C0G	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity)
C5O14_06210	ENOG4108Z6B	deaminase
C5O14_06215	ENOG4105DKQ	ROK family
C5O14_06220	ENOG4105C59	p-type ATPase
C5O14_06225	ENOG4105C4P	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity)
C5O14_06230	ENOG4105GVR	general secretion pathway protein D
C5O14_06260	ENOG4105C3B	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity)
C5O14_06270	ENOG4107RAQ	aminopeptidase
C5O14_06275	ENOG4105E21	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity)
C5O14_06300	ENOG4105BZU	Histidine kinase
C5O14_06305	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
C5O14_06310	ENOG4105C01	Dihydroxy-acid dehydratase
C5O14_06335	ENOG4105E0M	Sulfatase
C5O14_06375	ENOG4105CMR	udp-glucose 4-epimerase
C5O14_06380	ENOG4105D1X	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity)
C5O14_06400	ENOG4107QI1	Mate efflux family protein
C5O14_06540	ENOG4105D9K	One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity)
C5O14_06545	ENOG4105C8X	One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity)
C5O14_06550	ENOG4108R80	One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity)
C5O14_06555	ENOG4105C08	Histidine kinase
C5O14_06565	ENOG4105E46	N-alpha,N-alpha,N-alpha-trimethyl-L-histidine metabolic process
C5O14_06575	ENOG4108RW0	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity)
C5O14_06595	ENOG4105V75	Transcriptional regulator
C5O14_06645	ENOG4105C7R	Atpase associated with various cellular activities aaa_3
C5O14_06670	ENOG4105ECP	epimerase
C5O14_06685	ENOG4105C6M	Alpha-keto-beta-hydroxylacyl reductoisomerase
C5O14_06690	ENOG4105DKW	ABC transporter
C5O14_06695	ENOG4105C6F	GntR Family Transcriptional Regulator
C5O14_06710	ENOG4107QRH	Arylsulfatase (Ec 3.1.6.1)
C5O14_06720	ENOG4105C70	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity)
C5O14_06735	ENOG4105CJ2	(LipO)protein
C5O14_06750	ENOG41085AM	50S ribosomal protein L28
C5O14_06765	ENOG41080G3	Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity)
C5O14_06770	ENOG4105CJT	Mannose-1-phosphate guanylyltransferase
C5O14_06780	ENOG4105DNX	Dna topoisomerase iv (Subunit b)
C5O14_06785	ENOG4105CTR	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity)
C5O14_06795	ENOG4105DVT	helicase
C5O14_06800	ENOG4108JJB	ABC transporter
C5O14_06825	ENOG4105CAS	nag kinase
C5O14_06830	ENOG4107QUT	magnesium and cobalt transport protein CorA
C5O14_06835	ENOG4105K9Q	Binds to the 23S rRNA (By similarity)
C5O14_06840	ENOG4105DC1	bifunctional purine biosynthesis protein purh
C5O14_06845	ENOG4105CSZ	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity)
C5O14_06850	ENOG410829W	Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity)
C5O14_06860	ENOG4105C0M	Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle (By similarity)
C5O14_06865	ENOG4108VPC	n-acetylmuramoyl-l-alanine amidase
C5O14_06880	ENOG4107SFQ	iron-sulfur binding
C5O14_06900	ENOG4105D49	3-dehydroquinate synthase
C5O14_06955	ENOG4105SKN	orotidine 5''-phosphate decarboxylase
C5O14_06975	ENOG410816I	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity)
C5O14_06980	ENOG4105C6E	dna polymerase iii
C5O14_07000	ENOG4105W5Q	DNA repair protein (RadC
C5O14_07005	ENOG4105DR1	Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity)
C5O14_07010	ENOG4105K9U	however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity)
C5O14_07015	ENOG4108UM5	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity)
C5O14_07020	ENOG4108UJD	30S ribosomal protein S9
C5O14_07025	ENOG4108UXA	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity)
C5O14_07030	ENOG4105CII	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity)
C5O14_07040	ENOG4109015	Biopolymer transport protein exbD tolR
C5O14_07050	ENOG4108JQC	penicillin-binding protein 1A
C5O14_07055	ENOG4105ECY	inositol monophosphatase
C5O14_07060	ENOG4108UH8	Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity)
C5O14_07070	ENOG4105DG6	mannose-6-phosphate isomerase
C5O14_07080	ENOG4105DFD	Na H antiporter
C5O14_07085	ENOG4105C30	Nad-dependent epimerase dehydratase
C5O14_07090	ENOG4105C0K	Gdp-mannose 4,6-dehydratase
C5O14_07095	ENOG4105C1M	carbamoyl-phosphate synthetase glutamine chain
C5O14_07100	ENOG4105CU6	carbamoyl-phosphate synthetase ammonia chain
C5O14_07110	ENOG4105CBC	glutamate synthase
C5O14_07115	ENOG4105DHW	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
C5O14_07120	ENOG4105VAS	Could be involved in insertion of integral membrane proteins into the membrane (By similarity)
C5O14_07150	ENOG4105DSB	aldose 1-epimerase
C5O14_07160	ENOG4105D18	nicotinate-nucleotide pyrophosphorylase
C5O14_07170	ENOG4105CM3	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity)
C5O14_07185	ENOG4105EJQ	L-serine dehydratase
C5O14_07190	ENOG4105C3M	thioredoxin reductase
C5O14_07235	ENOG4105CKD	glutathione-regulated potassium-efflux system protein
C5O14_07240	ENOG4105DIN	metallophosphoesterase
C5O14_07250	ENOG4108V3E	phosphoribosylglycinamide formyltransferase
C5O14_07255	ENOG4108V1T	peptidylprolyl cis-trans isomerase
C5O14_07280	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
C5O14_07290	ENOG4105CFP	Peptidase U32
C5O14_07300	ENOG4105E6M	Sulphatase-modifying factor protein
C5O14_07320	ENOG4105ET1	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity)
C5O14_07340	ENOG4105C3T	may be the GTPase, regulating ATP sulfurylase activity (By similarity)
C5O14_07345	ENOG4105C11	sulfate adenylyltransferase), subunit 2
C5O14_07360	ENOG4108UTW	Plays a role in the regulation of phosphate uptake
C5O14_07365	ENOG4105BZY	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity)
C5O14_07370	ENOG4105E2Z	phosphate ABC transporter (Permease
C5O14_07375	ENOG4105C8U	phosphate abc transporter
C5O14_07380	ENOG4105DJH	phosphate
C5O14_07385	ENOG4105BZY	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity)
C5O14_07395	ENOG4105ENN	converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity)
C5O14_07410	ENOG4105C1V	Peptidase, M16
C5O14_07425	ENOG4108UW5	maltose o-acetyltransferase
C5O14_07455	ENOG4108VCV	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity)
C5O14_07460	ENOG4105C41	Catalyzes the reversible phosphorylation of UMP to UDP (By similarity)
C5O14_07475	ENOG4105D3R	alkyl hydroperoxide reductase
C5O14_07480	ENOG4105C8J	)-transporter
C5O14_07505	ENOG4105C0Q	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity)
C5O14_07510	ENOG4105E0X	reductase
C5O14_07515	ENOG4105CQ3	Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity)
C5O14_07535	ENOG4107QWP	ABC-2 type transporter
C5O14_07540	ENOG4107QWP	ABC-2 type transporter
C5O14_07545	ENOG4105CJ1	ABC, transporter
C5O14_07555	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
C5O14_07560	ENOG4106PT6	cdpdiacylglycerol-serine O-phosphatidyltransferase
C5O14_07570	ENOG4105EEI	dihydropteroate synthase
C5O14_07580	ENOG4105C4E	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity)
C5O14_07585	ENOG4105CHR	reductase
C5O14_07610	ENOG4107EEK	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity)
C5O14_07630	ENOG4105C9M	aspartyl-trna synthetase
C5O14_07635	ENOG4105CUT	histidyl-tRNA synthetase
C5O14_07655	ENOG4105CQS	hydrogenase expression formation protein HypD
C5O14_07660	ENOG4105C45	hydrogenase expression formation protein (HypE)
C5O14_07680	ENOG4105CFG	Acts as a chaperone (By similarity)
C5O14_07685	ENOG4105K5Y	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity)
C5O14_07690	ENOG4105CJ9	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
C5O14_07725	ENOG4105D75	Capsular exopolysaccharide family
C5O14_07740	ENOG4105KA4	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity)
C5O14_07750	ENOG4105BZA	Phosphoglycerate kinase
C5O14_07765	ENOG4105CGS	Alpha-glucosidase
C5O14_07775	ENOG4107YVC	modification (methylase)
C5O14_07785	ENOG4108JA2	transcriptioN-repair coupling factor
C5O14_07795	ENOG4105DJB	Major Facilitator Superfamily
C5O14_07810	ENOG4107RVV	histidinol phosphate phosphatase, hisj family
C5O14_07815	ENOG4105C6K	Malic enzyme
C5O14_07820	ENOG4105D3U	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity)
C5O14_07825	ENOG4105NRA	50s ribosomal protein l31 type b
C5O14_07860	ENOG4105C6Y	Udp-glucose 6-dehydrogenase
C5O14_07865	ENOG4105D9Z	Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity)
C5O14_07890	ENOG4108RCM	Nitroreductase
C5O14_07895	ENOG4105C34	Pseudouridine synthase
C5O14_07900	ENOG4105I08	Pseudouridine synthase
C5O14_07920	ENOG4105CDA	abc transporter atp-binding protein
C5O14_07925	ENOG4105E5Q	amino acid AbC transporter
C5O14_07935	ENOG4105C0N	N-acetylglutamate semialdehyde dehydrogenase
C5O14_07990	ENOG4105VZ9	UPF0235 protein
C5O14_07995	ENOG4105K90	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
C5O14_08000	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
C5O14_08005	ENOG4105QF0	Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity)
C5O14_08015	ENOG41084I7	Alpha-galactosidase. Removes both branched alpha-1,3- linked galactose residues of blood group B antigens and linear alpha-1,3-linked galactose structures
C5O14_08030	ENOG4105CQB	FAD linked oxidase domain protein
C5O14_08055	ENOG4105C5T	Phosphoribosyl pyrophosphate synthase
C5O14_08060	ENOG4105KW6	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity)
C5O14_08075	ENOG4105ECC	imidazole-glycerol-phosphate dehydratase
C5O14_08080	ENOG4108UJE	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity)
C5O14_08085	ENOG4107Q5Z	Binds together with S18 to 16S ribosomal RNA (By similarity)
C5O14_08095	ENOG4105CEZ	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity)
C5O14_08110	ENOG4105DZ1	carboxypeptidase
C5O14_08115	ENOG4105CTQ	phosphohexokinase
C5O14_08125	ENOG4105DUN	Mediates zinc uptake. May also transport other divalent cations (By similarity)
C5O14_08130	ENOG4105MH8	Thioredoxin disulfide isomerase
C5O14_08140	ENOG4105JKW	Valine--pyruvate aminotransferase
C5O14_08145	ENOG4105DSJ	YicC domain protein
C5O14_08160	ENOG4106F3G	Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity)
C5O14_08175	ENOG4105EIS	1,4-dihydroxy-2-naphthoate octaprenyltransferase
C5O14_08200	ENOG4105DBW	Multi-copper polyphenol oxidoreductase laccase
C5O14_08215	ENOG4105C3D	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
C5O14_08230	ENOG4105EHH	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue (By similarity)
C5O14_08240	ENOG4105CTF	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
C5O14_08245	ENOG4108ZT0	50S ribosomal protein l17
C5O14_08250	ENOG4105CJF	Malonyl coA-acyl carrier protein transacylase
C5O14_08255	ENOG4107YBY	Hydrolase
C5O14_08270	ENOG4105KCK	Peptidoglycan-associated lipoprotein
C5O14_08330	ENOG4105CPC	Aldo Keto reductase
C5O14_08335	ENOG4105EAY	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
C5O14_08355	ENOG4105CRQ	synthase (Component I)
C5O14_08360	ENOG4108I0Q	anthranilate phosphoribosyltransferase
C5O14_08365	ENOG4105DK0	Indole-3-glycerol phosphate synthase
C5O14_08370	ENOG4108ZGB	N-(5'-phosphoribosyl)anthranilate isomerase
C5O14_08375	ENOG4105CG0	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity)
C5O14_08380	ENOG4105F6H	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity)
C5O14_08400	ENOG4105DWV	Homoserine O-trans-acetylase
C5O14_08405	ENOG4105YK5	50S ribosomal protein L36
C5O14_08415	ENOG4105F1A	Pyruvate formate-lyase
C5O14_08455	ENOG4108HCJ	Hydrolase
C5O14_08460	ENOG4105KWU	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
C5O14_08465	ENOG4106UW1	Major Facilitator superfamily
C5O14_08485	ENOG4105CCW	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity)
C5O14_08490	ENOG4105VJV	50s ribosomal protein L35
C5O14_08495	ENOG4108YZX	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity)
C5O14_08515	ENOG4107R2I	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation
C5O14_08525	ENOG410631K	Membrane
C5O14_08530	ENOG4107S85	alpha-2-macroglobulin domain protein
C5O14_08550	ENOG4105K85	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity)
C5O14_08575	ENOG4105BZN	citrate synthase
C5O14_08595	ENOG4108UH4	Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity)
C5O14_08605	ENOG4108R99	pseudouridine synthase
C5O14_08615	ENOG4108UGX	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity)
C5O14_08625	ENOG4105CKK	Glycosyl transferase, family 2
C5O14_08635	ENOG4105D7Q	type ii secretion system
C5O14_08640	ENOG4107QHF	type ii secretion system protein e
C5O14_08645	ENOG4107QHF	type ii secretion system protein e
C5O14_08650	ENOG4105CEH	Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity)
C5O14_08665	ENOG4105CJR	Integral membrane protein (MviN
C5O14_08670	ENOG4105DW0	Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity)
C5O14_08685	ENOG4105F32	YngK protein
C5O14_08690	ENOG4105DTC	1-(5-phosphoribosyl)-5-amino-4-imidazole-carboxylate (air) carboxylase
C5O14_08695	ENOG4105DVM	PP-loop domain protein
C5O14_08700	ENOG4105C8M	UPF0272 protein
C5O14_08705	ENOG4105EAH	synthase
C5O14_08720	ENOG4105VG1	fes assembly suf system protein
C5O14_08735	ENOG4105CNR	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
C5O14_08740	ENOG4105C8S	subunit m
C5O14_08755	ENOG4105M5H	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
C5O14_08760	ENOG4107UFS	subunit j
C5O14_08770	ENOG4105CMZ	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity)
C5O14_08775	ENOG4108IEH	NADH dehydrogenase subunit g
C5O14_08780	ENOG4107EEP	NADH dehydrogenase (quinone) (EC 1.6.99.5)
C5O14_08785	ENOG4105GKE	subunit e
C5O14_08790	ENOG4105CQV	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
C5O14_08800	ENOG4107BJW	polysaccharide deacetylase
C5O14_08810	ENOG4108R6K	riboflavin synthase, subunit alpha
C5O14_08815	ENOG4105F59	Methylates ribosomal protein L11 (By similarity)
C5O14_08835	ENOG4107S1W	4-alpha-glucanotransferase
C5O14_08845	ENOG4105CBM	Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity)
C5O14_08850	ENOG4105F7J	membrane-bound serine protease
C5O14_08855	ENOG4105C9G	DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity)
C5O14_08860	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
C5O14_08865	ENOG4108UQS	dipeptidase
C5O14_08880	ENOG4105C65	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity)
C5O14_08885	ENOG4105CN1	protease
C5O14_08900	ENOG4105CQ7	ATP-dependent helicase
C5O14_08925	ENOG4105GVR	general secretion pathway protein D
C5O14_08940	ENOG4105CN0	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity)
C5O14_08960	ENOG4105FBT	Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity)
C5O14_08965	ENOG4107RAJ	Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity)
C5O14_08975	ENOG410872P	Binds directly to 16S ribosomal RNA (By similarity)
C5O14_08980	ENOG4107VXZ	Hydrolase
C5O14_08985	ENOG4105C7K	acetolactate synthase
C5O14_08995	ENOG4105DJ4	phosphatidylserine decarboxylase
C5O14_09005	ENOG4105C8T	Leucyl-tRNA synthetase
C5O14_09010	ENOG4105ENH	Sulfatase
C5O14_09025	ENOG4105DP5	Catalyzes the biosynthesis of agmatine from arginine (By similarity)
C5O14_09040	ENOG4105CNT	hydrolase family 2
C5O14_09045	ENOG4105CNT	hydrolase family 2
C5O14_09050	ENOG4105D1H	recombination factor protein RarA
C5O14_09055	ENOG4105E2D	ec 3.2.1.52
C5O14_09070	ENOG4105CTQ	phosphohexokinase
C5O14_09085	ENOG4105EZY	Pyrroloquinoline quinone biosynthesis protein E
C5O14_09120	ENOG4108YZT	Adenosylcobinamide kinase
C5O14_09135	ENOG4105CUP	Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity)
C5O14_09140	ENOG4105DH2	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity)
C5O14_09145	ENOG4105CAA	catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity)
C5O14_09155	ENOG4107ENK	receptor
C5O14_09175	ENOG4107SYB	Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity)
C5O14_09180	ENOG4107QN2	dihydrolipoyl dehydrogenase
C5O14_09200	ENOG4105CFY	cytochrome d ubiquinol oxidase, subunit ii
C5O14_09205	ENOG4105C4M	(Ubiquinol oxidase) subunit I
C5O14_09215	ENOG4107WAU	Protein tyrosine phosphatase
C5O14_09235	ENOG410834F	Transcriptional regulator
C5O14_09260	ENOG4108UB4	uncharacterized protein ygjQ
C5O14_09290	ENOG4105C9U	ATP-dependent DNA helicase RecQ
C5O14_09305	ENOG4105CH8	Succinyl-CoA ligase ADP-forming subunit alpha
C5O14_09310	ENOG4105CMV	Succinyl-CoA synthetase subunit beta
C5O14_09350	ENOG4105DVS	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity)
C5O14_09355	ENOG4105CEY	Amp-dependent synthetase and ligase
C5O14_09380	ENOG4108IAJ	Nad-dependent epimerase dehydratase
C5O14_09385	ENOG41065SU	Two-component system sensor kinase
C5O14_09400	ENOG4105D52	delta-aminolevulinic acid dehydratase
C5O14_09410	ENOG4105C22	threonyL-tRNA synthetase
C5O14_09415	ENOG4108UUX	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity)
C5O14_09430	ENOG4105CEA	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity)
C5O14_09460	ENOG4107R6G	Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity)
C5O14_09475	ENOG4105KPE	licD family
C5O14_09480	ENOG4107YSK	Glycerol-3-phosphate cytidylyltransferase
C5O14_09495	ENOG4105KPE	licD family
C5O14_09500	ENOG4105C9C	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity)
C5O14_09510	ENOG4105P9C	Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity)
C5O14_09515	ENOG4105DBV	ornithine carbamoyltransferase
C5O14_09520	ENOG4107QRH	Arylsulfatase (Ec 3.1.6.1)
C5O14_09525	ENOG4105BZ3	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity)
C5O14_09530	ENOG41080Z8	PHOSPHOCARRIER protein
C5O14_09535	ENOG4105D1C	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity)
C5O14_09540	ENOG4105C9Y	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity)
C5O14_09545	ENOG4105DA5	(ABC) transporter
C5O14_09560	ENOG4105DFA	alanine racemase domain protein
C5O14_09575	ENOG4105CND	Glycosyl transferase, family 2
C5O14_09590	ENOG4105FBQ	ATPase associated with various cellular activities aaa_5
C5O14_09590	ENOG4105FBQ	ATPase associated with various cellular activities aaa_5
C5O14_09605	ENOG4108ZB6	transcriptional regulator AsnC family
C5O14_09610	ENOG4105CHM	Aminotransferase
C5O14_09625	ENOG4105D9H	Catalyzes the attachment of glycine to tRNA(Gly) (By similarity)
C5O14_09630	ENOG4105CV8	reductase
C5O14_09645	ENOG4107QVM	von Willebrand factor, type A
C5O14_09660	ENOG4105C7R	Atpase associated with various cellular activities aaa_3
C5O14_09665	ENOG4105C3P	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity)
C5O14_09670	ENOG41081AP	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
C5O14_09710	ENOG4105C0H	protease
C5O14_09745	ENOG4105C87	Aminotransferase class I and II
C5O14_09755	ENOG4105CV8	reductase
C5O14_09760	ENOG4105ENX	hydrolase
C5O14_09765	ENOG4107SET	aldo keto reductase
C5O14_09770	ENOG4105DIN	metallophosphoesterase
C5O14_09790	ENOG4108MXQ	glutathione-regulated potassium-efflux system ancillary protein KefF
C5O14_09795	ENOG4105VUF	Transcriptional regulator
C5O14_09810	ENOG4105C3S	Mate efflux family protein
C5O14_09820	ENOG4105E2D	ec 3.2.1.52
C5O14_09835	ENOG4105DBZ	Dtdp-4-dehydrorhamnose reductase
C5O14_09850	ENOG4105VB6	UPF0109 protein
C5O14_09860	ENOG4105DR4	Methyltransferase
C5O14_09865	ENOG4105CKA	Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity)
C5O14_09890	ENOG4105C2I	pirin domain protein
C5O14_09910	ENOG4105CMG	Carbohydrate kinase
C5O14_09920	ENOG4105EHF	Converts the aldose L-fucose into the corresponding ketose L-fuculose (By similarity)
C5O14_09925	ENOG4105EDR	glucose galactose transporter
C5O14_09965	ENOG4105CBF	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity)
C5O14_09985	ENOG4105C0H	protease
C5O14_09995	ENOG4105EMK	carboxylate amino acid amine transporter
C5O14_10000	ENOG4108HFV	
C5O14_10010	ENOG4105CJ4	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity)
C5O14_10015	ENOG4108JQ7	(ABC) transporter
C5O14_10025	ENOG4108J59	Extracellular solute-binding protein, family 5
C5O14_10030	ENOG4108IYQ	Binding-protein-dependent transport systems inner membrane component
C5O14_10050	ENOG41084M5	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity)
C5O14_10055	ENOG4105CKU	formyltetrahydrofolate synthetase
C5O14_10060	ENOG4108XC3	NADH ubiquinone oxidoreductase
C5O14_10065	ENOG4107QNG	Phosphoribosylglycinamide synthetase
C5O14_10090	ENOG4108Z02	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity)
C5O14_10130	ENOG4105D6P	C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex (By similarity)
C5O14_10135	ENOG4105NQN	cytochrome C
C5O14_10150	ENOG4105MEV	Acyl-transferase
C5O14_10155	ENOG4108HMX	isocitrate dehydrogenase (NADP)
C5O14_10170	ENOG4105CY0	Metallo-Beta-Lactamase
C5O14_10175	ENOG4108ZMD	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity)
C5O14_10180	ENOG4105FD2	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity)
C5O14_10190	ENOG4105D64	Mechanosensitive ion channel
C5O14_10195	ENOG4105C20	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity)
C5O14_10200	ENOG410845M	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes (By similarity)
C5O14_10205	ENOG4105DWR	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity)
C5O14_10225	ENOG4105CMY	5-enolpyruvylshikimate-3-phosphate synthase
C5O14_10235	ENOG4105CDF	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity)
C5O14_10245	ENOG4105D10	5-enolpyruvylshikimate-3-phosphate phospholyase
C5O14_10255	ENOG4107EER	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity)
C5O14_10265	ENOG4105DIN	metallophosphoesterase
C5O14_10285	ENOG4105DVP	Adenine-specific
C5O14_10290	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
C5O14_10310	ENOG4108JB8	alcohol dehydrogenase
C5O14_10315	ENOG4105WMR	Protein CrcB homolog
C5O14_10330	ENOG4105C7C	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
C5O14_10345	ENOG4107RI4	Transfers the fatty acyl group on membrane lipoproteins (By similarity)
C5O14_10375	ENOG4105CRE	cytochrome C
C5O14_10390	ENOG4108IPW	abc transporter atp-binding protein
C5O14_10395	ENOG4105CM4	permease protein
C5O14_10400	ENOG4105DHS	permease protein
C5O14_10435	ENOG4105C2M	dna polymerase I
C5O14_10450	ENOG4105C83	adenylosuccinate lyase
C5O14_10455	ENOG4105D42	Cleaves the N-terminal amino acid of tripeptides (By similarity)
C5O14_10475	ENOG4105CDP	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity)
C5O14_10520	ENOG4108Z66	YbaK ebsC protein
C5O14_10560	ENOG4105C3R	Methionine synthase
C5O14_10565	ENOG4105DWK	Membrane
C5O14_10570	ENOG4107XM3	UPF0442 protein
C5O14_10585	ENOG4105CFH	Aspartokinase
C5O14_10605	ENOG4105BZH	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
C5O14_10615	ENOG4105E2X	shikimate dehydrogenase
C5O14_10625	ENOG4108R4Z	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity)
C5O14_10630	ENOG4108HRN	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity)
C5O14_10640	ENOG4107QP8	phosphohexose isomerase
C5O14_10650	ENOG4105DR4	Methyltransferase
C5O14_10660	ENOG4105D5P	Methylmalonyl-coA mutase
C5O14_10700	ENOG4108R3E	Dna-3-methyladenine glycosylase i
C5O14_10720	ENOG4105C0F	tryptophanase EC 4.1.99.1
C5O14_10735	ENOG4105C6A	phenylalanyl-tRNA synthetase (beta subunit)
C5O14_10760	ENOG4105CJX	Molecular chaperone. Has ATPase activity (By similarity)
C5O14_10785	ENOG4105CJ4	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity)
C5O14_10790	ENOG4108ZF1	Transcriptional regulator, BadM Rrf2 family
C5O14_10805	ENOG4108UV6	Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity)
C5O14_10810	ENOG4105C4U	4-methyl-5-beta-hydroxyethylthiazole kinase
C5O14_10825	ENOG4105E2D	ec 3.2.1.52
C5O14_10830	ENOG4105E2D	ec 3.2.1.52
C5O14_10835	ENOG4105DJT	lAO AO transport system ATPase
C5O14_10855	ENOG41081ID	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity)
C5O14_10860	ENOG4105C1J	atp-dependent rna helicase
C5O14_10865	ENOG4105C5X	domain protein
C5O14_10870	ENOG4105EKE	dihydroorotase
C5O14_10885	ENOG4105ENT	Efflux transporter rnd family, mfp subunit
C5O14_10895	ENOG4108YYV	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity)
C5O14_10905	ENOG4105CQX	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity)
C5O14_10910	ENOG4107QSA	Oxaloacetate decarboxylase
C5O14_10920	ENOG4107QI1	Mate efflux family protein
C5O14_10925	ENOG4105D1F	ATP-binding protein
C5O14_10940	ENOG4105CYQ	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity)
C5O14_10945	ENOG4105DGW	oligopeptidase A
C5O14_10950	ENOG4105ENT	Efflux transporter rnd family, mfp subunit
C5O14_10960	ENOG4105ENJ	RND efflux system, outer membrane lipoprotein
C5O14_10975	ENOG4105U6W	MutT NUDIX family protein
C5O14_11010	ENOG4105D82	Glutamate dehydrogenase
C5O14_11020	ENOG4105D0V	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
C5O14_11025	ENOG4107T5V	SNARE associated Golgi
C5O14_11095	ENOG4105DYN	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity)
C5O14_11110	ENOG4105FB9	CRISPR-associated protein
C5O14_11130	ENOG4105C26	Dehydrogenase
C5O14_11150	ENOG4105CH6	catalase
C5O14_11160	ENOG4105CRE	cytochrome C
C5O14_11170	ENOG4108RAC	Rubrerythrin
C5O14_11175	ENOG41068WN	
C5O14_11185	ENOG4105CNU	cell division protein FtsK
C5O14_11205	ENOG4108QV3	biosynthesis protein
C5O14_11210	ENOG4108RB3	Capsular polysaccharide biosynthesis protein
C5O14_11215	ENOG4105D3Q	Sugar transferase
C5O14_11240	ENOG4105K64	Glycosyl transferase, family 2
C5O14_11255	ENOG4105E2K	Glycosyl transferase (Group 1
C5O14_11260	ENOG4107T8Q	Glycosyl transferase (Group 1
C5O14_11285	ENOG4105ECJ	Glycosyl Transferase
C5O14_11310	ENOG4105EXC	Acyl-transferase
C5O14_11330	ENOG4105C87	Aminotransferase class I and II
C5O14_11335	ENOG4105CKH	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity)
C5O14_11340	ENOG4105C4A	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity)
C5O14_11350	ENOG4105C6K	Malic enzyme
C5O14_11365	ENOG4107QPA	Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides (By similarity)
C5O14_11385	ENOG4105CSA	Coproporphyrinogen iii oxidase
C5O14_11420	ENOG4105CGR	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity)
C5O14_11425	ENOG4105CPQ	Dehydrogenase
C5O14_11440	ENOG4105C7R	Atpase associated with various cellular activities aaa_3
C5O14_11450	ENOG4108ZPD	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity)
C5O14_11455	ENOG4105BZ4	penicillin-binding protein
C5O14_11470	ENOG4105C91	Plays an important role in the de novo pathway of purine nucleotide biosynthesis
C5O14_11490	ENOG4105E3S	small subunit
C5O14_11495	ENOG4105DPX	Hydrogenase, large subunit
C5O14_11505	ENOG4108USZ	hydrogenase
C5O14_11510	ENOG4105WMM	Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity)
C5O14_11540	ENOG4108RCM	Nitroreductase
C5O14_11545	ENOG4105CIH	Imidazole acetol-phosphate transaminase
C5O14_11565	ENOG4105C3D	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
C5O14_11595	ENOG4107YVC	modification (methylase)
C5O14_11615	ENOG4105E2D	ec 3.2.1.52
C5O14_11665	ENOG4105ES3	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
C5O14_11670	ENOG4105CYU	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
C5O14_11685	ENOG4105CEY	Amp-dependent synthetase and ligase
C5O14_11715	ENOG4105DGW	oligopeptidase A
C5O14_11725	ENOG4105C75	arginyL-tRNA synthetase
C5O14_11765	ENOG4105C5U	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity)
C5O14_11770	ENOG4105CI6	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving
C5O14_11775	ENOG4107QZM	n-acetylglutamate synthase
C5O14_11790	ENOG4108YZ4	nudix hydrolase