locus-tag	class	description
DMI75_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
DMI75_00010	COG1131	(ABC) transporter
DMI75_00030	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
DMI75_00035	COG0564	pseudouridine synthase activity
DMI75_00060	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
DMI75_00065	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
DMI75_00075	COG0513	Belongs to the DEAD box helicase family
DMI75_00090	COG0673	inositol 2-dehydrogenase activity
DMI75_00115	COG2814	Major facilitator Superfamily
DMI75_00120	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
DMI75_00130	COG1971	Probably functions as a manganese efflux pump
DMI75_00155	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DMI75_00180	COG0442	prolyl-tRNA aminoacylation
DMI75_00235	COG0531	amino acid
DMI75_00240	COG2066	Belongs to the glutaminase family
DMI75_00255	COG1115	amino acid carrier protein
DMI75_00270	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
DMI75_00275	COG2890	protein-(glutamine-N5) methyltransferase activity
DMI75_00280	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
DMI75_00285	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
DMI75_00305	COG2226	methyltransferase
DMI75_00310	COG0534	Mate efflux family protein
DMI75_00325	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DMI75_00330	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
DMI75_00335	COG3525	Glycosyl hydrolase, family 20, catalytic domain
DMI75_00355	COG1121	(ABC) transporter
DMI75_00360	COG1108	ABC-type Mn2 Zn2 transport systems permease components
DMI75_00365	COG3880	PFAM UvrB UvrC protein
DMI75_00370	COG3869	Catalyzes the specific phosphorylation of arginine residues in
DMI75_00375	COG0542	response to heat
DMI75_00385	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DMI75_00390	COG0179	Fumarylacetoacetate (FAA) hydrolase
DMI75_00395	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DMI75_00410	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
DMI75_00410	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
DMI75_00420	COG0180	Tryptophanyl-tRNA synthetase
DMI75_00430	COG1692	metallophosphoesterase
DMI75_00440	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
DMI75_00455	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DMI75_00460	COG0246	Mannitol dehydrogenase
DMI75_00465	COG0738	Major facilitator superfamily
DMI75_00485	COG0156	8-amino-7-oxononanoate synthase activity
DMI75_00495	COG1192	Involved in chromosome partitioning
DMI75_00500	COG0515	serine threonine protein kinase
DMI75_00500	COG3266	domain, Protein
DMI75_00540	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
DMI75_00550	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
DMI75_00560	COG3189	MarR family transcriptional regulator
DMI75_00565	COG0181	hydroxymethylbilane synthase activity
DMI75_00570	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
DMI75_00580	COG1469	GTP cyclohydrolase I activity
DMI75_00585	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
DMI75_00590	COG0267	Belongs to the bacterial ribosomal protein bL33 family
DMI75_00595	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
DMI75_00605	COG1940	carbohydrate kinase activity
DMI75_00620	COG0494	nUDIX hydrolase
DMI75_00630	COG1136	(ABC) transporter
DMI75_00630	COG0577	efflux transmembrane transporter activity
DMI75_00635	COG1136	(ABC) transporter
DMI75_00635	COG0577	efflux transmembrane transporter activity
DMI75_00640	COG1538	Outer membrane efflux protein
DMI75_00675	COG1720	tRNA m6t6A37 methyltransferase activity
DMI75_00680	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
DMI75_00685	COG0540	Belongs to the ATCase OTCase family
DMI75_00690	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
DMI75_00735	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
DMI75_00740	COG2957	Belongs to the agmatine deiminase family
DMI75_00945	COG0750	zinc metalloprotease
DMI75_00955	COG3119	arylsulfatase activity
DMI75_00965	COG1918	ferrous iron import across plasma membrane
DMI75_00965	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
DMI75_01005	COG1475	DNA binding
DMI75_01040	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
DMI75_01050	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DMI75_01055	COG0601	transmembrane transport
DMI75_01115	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
DMI75_01130	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DMI75_01135	COG1132	(ABC) transporter
DMI75_01140	COG1132	(ABC) transporter
DMI75_01155	COG1127	ABC transporter
DMI75_01160	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
DMI75_01195	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DMI75_01220	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
DMI75_01225	COG0504	CTP synthase activity
DMI75_01230	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DMI75_01270	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DMI75_01280	COG1322	Protein conserved in bacteria
DMI75_01285	COG0546	phosphoglycolate phosphatase activity
DMI75_01290	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
DMI75_01300	COG4591	ABC-type transport system involved in lipoprotein release permease component
DMI75_01300	COG4591	ABC-type transport system involved in lipoprotein release permease component
DMI75_01325	COG2234	aminopeptidase activity
DMI75_01330	COG0657	acetylesterase activity
DMI75_01330	COG2755	lipolytic protein G-D-S-L family
DMI75_01335	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
DMI75_01355	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
DMI75_01390	COG0335	large ribosomal subunit rRNA binding
DMI75_01400	COG0346	lactoylglutathione lyase activity
DMI75_01415	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
DMI75_01420	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
DMI75_01430	COG0427	acetyl-CoA hydrolase
DMI75_01440	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
DMI75_01450	COG0205	6-phosphofructokinase activity
DMI75_01465	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DMI75_01470	COG0028	Belongs to the TPP enzyme family
DMI75_01485	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
DMI75_01500	COG0471	metal ion transport
DMI75_01510	COG0351	phosphomethylpyrimidine kinase
DMI75_01590	COG1028	Short-chain dehydrogenase reductase Sdr
DMI75_01600	COG0242	peptide deformylase activity
DMI75_01605	COG1063	alcohol dehydrogenase
DMI75_01615	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DMI75_01620	COG1393	Belongs to the ArsC family
DMI75_01625	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
DMI75_01640	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
DMI75_01655	COG1187	pseudouridine synthase activity
DMI75_01665	COG0336	Belongs to the RNA methyltransferase TrmD family
DMI75_01670	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
DMI75_01680	COG0539	negative regulation of cytoplasmic translation
DMI75_01725	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
DMI75_01730	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
DMI75_01735	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
DMI75_01775	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DMI75_01795	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
DMI75_01795	COG0662	Cupin 2, conserved barrel domain protein
DMI75_01805	COG0416	fatty acid biosynthetic process
DMI75_01810	COG0333	Belongs to the bacterial ribosomal protein bL32 family
DMI75_01820	COG0537	adenosine 5'-monophosphoramidase activity
DMI75_01825	COG0009	L-threonylcarbamoyladenylate synthase
DMI75_01830	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
DMI75_01835	COG0228	four-way junction DNA binding
DMI75_01860	COG0343	queuine tRNA-ribosyltransferase activity
DMI75_01865	COG0220	tRNA (guanine-N7-)-methyltransferase activity
DMI75_01875	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
DMI75_01885	COG0776	regulation of translation
DMI75_01920	COG0811	peptide transport
DMI75_01935	COG3250	beta-galactosidase activity
DMI75_01940	COG0525	valine-tRNA ligase activity
DMI75_01950	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
DMI75_01955	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
DMI75_01960	COG0255	Belongs to the universal ribosomal protein uL29 family
DMI75_01965	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
DMI75_01970	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
DMI75_01975	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
DMI75_01985	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
DMI75_01990	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
DMI75_01995	COG0089	rRNA binding
DMI75_02000	COG0088	Forms part of the polypeptide exit tunnel
DMI75_02005	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
DMI75_02010	COG0051	transcription antitermination factor activity, RNA binding
DMI75_02015	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
DMI75_02020	COG0049	tRNA binding
DMI75_02025	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
DMI75_02035	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
DMI75_02045	COG3852	Histidine kinase
DMI75_02050	COG2204	response regulator
DMI75_02060	COG1722	exodeoxyribonuclease VII activity
DMI75_02065	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
DMI75_02080	COG0795	lipopolysaccharide-transporting ATPase activity
DMI75_02085	COG1160	GTP binding
DMI75_02090	COG0444	Belongs to the ABC transporter superfamily
DMI75_02125	COG0577	efflux transmembrane transporter activity
DMI75_02125	COG1136	(ABC) transporter
DMI75_02180	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
DMI75_02185	COG0799	negative regulation of ribosome biogenesis
DMI75_02190	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DMI75_02240	COG1136	(ABC) transporter
DMI75_02255	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
DMI75_02265	COG4221	oxidoreductase activity
DMI75_02285	COG0038	chloride channel
DMI75_02300	COG3525	Glycosyl hydrolase, family 20, catalytic domain
DMI75_02330	COG0067	glutamate synthase
DMI75_02330	COG0070	glutamate synthase
DMI75_02330	COG0069	glutamate synthase activity
DMI75_02340	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
DMI75_02345	COG0505	Belongs to the CarA family
DMI75_02350	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
DMI75_02355	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DMI75_02360	COG1757	Na H antiporter
DMI75_02370	COG1482	cell wall glycoprotein biosynthetic process
DMI75_02380	COG0076	glutamate decarboxylase activity
DMI75_02385	COG3468	outer membrane autotransporter barrel domain protein
DMI75_02400	COG0167	dihydroorotate dehydrogenase activity
DMI75_02405	COG0352	thiamine-phosphate diphosphorylase activity
DMI75_02425	COG1253	flavin adenine dinucleotide binding
DMI75_02430	COG1253	flavin adenine dinucleotide binding
DMI75_02440	COG1185	polyribonucleotide nucleotidyltransferase activity
DMI75_02460	COG1309	transcriptional regulator
DMI75_02465	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
DMI75_02495	COG0101	tRNA pseudouridine synthase activity
DMI75_02500	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
DMI75_02520	COG4968	Prepilin-type N-terminal cleavage methylation domain
DMI75_02525	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
DMI75_02535	COG3525	Glycosyl hydrolase, family 20, catalytic domain
DMI75_02540	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
DMI75_02560	COG2234	aminopeptidase activity
DMI75_02565	COG1136	(ABC) transporter
DMI75_02570	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
DMI75_02580	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
DMI75_02605	COG3525	Glycosyl hydrolase, family 20, catalytic domain
DMI75_02615	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
DMI75_02620	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
DMI75_02630	COG0828	Belongs to the bacterial ribosomal protein bS21 family
DMI75_02635	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
DMI75_02645	COG2814	Major facilitator Superfamily
DMI75_02655	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DMI75_02660	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DMI75_02660	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DMI75_02665	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
DMI75_02670	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DMI75_02675	COG0552	protein localization to endoplasmic reticulum
DMI75_02680	COG0820	rRNA (adenine-C2-)-methyltransferase activity
DMI75_02705	COG1058	Belongs to the CinA family
DMI75_02705	COG1546	Belongs to the CinA family
DMI75_02715	COG0456	acetyltransferase
DMI75_02740	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
DMI75_02745	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
DMI75_02750	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
DMI75_02755	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
DMI75_02770	COG0758	DNA mediated transformation
DMI75_02780	COG1686	Belongs to the peptidase S11 family
DMI75_02785	COG0012	GTP binding
DMI75_02790	COG0404	The glycine cleavage system catalyzes the degradation of glycine
DMI75_02800	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
DMI75_02800	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
DMI75_02815	COG3119	arylsulfatase activity
DMI75_02855	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
DMI75_02875	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DMI75_02885	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
DMI75_02905	COG2326	polyphosphate kinase activity
DMI75_02910	COG1349	DNA-binding transcription factor activity
DMI75_02930	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
DMI75_02950	COG0742	ribosomal rna small subunit methyltransferase
DMI75_02965	COG2326	polyphosphate kinase activity
DMI75_02970	COG5434	Belongs to the glycosyl hydrolase 28 family
DMI75_02975	COG1073	alpha beta
DMI75_02980	COG0802	atpase or kinase
DMI75_02985	COG0261	This protein binds to 23S rRNA in the presence of protein L20
DMI75_02990	COG0211	Belongs to the bacterial ribosomal protein bL27 family
DMI75_02995	COG0735	belongs to the Fur family
DMI75_03000	COG0396	ATPase activity
DMI75_03005	COG0719	Fe-S assembly protein
DMI75_03035	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
DMI75_03075	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
DMI75_03120	COG3209	COG3209 Rhs family protein
DMI75_03145	COG0355	proton-transporting ATP synthase activity, rotational mechanism
DMI75_03150	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
DMI75_03155	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
DMI75_03160	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
DMI75_03165	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
DMI75_03170	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
DMI75_03180	COG0356	it plays a direct role in the translocation of protons across the membrane
DMI75_03265	COG1045	serine acetyltransferase
DMI75_03275	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
DMI75_03280	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
DMI75_03290	COG0753	catalase activity
DMI75_03300	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
DMI75_03310	COG3119	arylsulfatase activity
DMI75_03335	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
DMI75_03345	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
DMI75_03350	COG0047	phosphoribosylformylglycinamidine synthase activity
DMI75_03360	COG1363	Peptidase, m42
DMI75_03380	COG1077	Cell shape determining protein MreB Mrl
DMI75_03385	COG1530	ribonuclease E activity
DMI75_03420	COG0848	biopolymer transport protein
DMI75_03435	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
DMI75_03460	COG0134	indole-3-glycerol-phosphate synthase activity
DMI75_03470	COG0792	nuclease activity
DMI75_03480	COG1253	flavin adenine dinucleotide binding
DMI75_03490	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
DMI75_03505	COG0137	argininosuccinate synthase activity
DMI75_03510	COG3119	arylsulfatase activity
DMI75_03520	COG0149	triose-phosphate isomerase activity
DMI75_03555	COG1040	competence protein
DMI75_03565	COG3956	TIGRFAM MazG family protein
DMI75_03610	COG1663	tetraacyldisaccharide 4'-kinase activity
DMI75_03615	COG0612	Peptidase, M16
DMI75_03655	COG0673	inositol 2-dehydrogenase activity
DMI75_03660	COG3034	peptidoglycan biosynthetic process
DMI75_03680	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
DMI75_03685	COG0424	maF-like protein
DMI75_03695	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
DMI75_03700	COG2815	serine threonine protein kinase
DMI75_03700	COG0515	serine threonine protein kinase
DMI75_03715	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
DMI75_03725	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
DMI75_03735	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
DMI75_03745	COG0571	ribonuclease III activity
DMI75_03765	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
DMI75_03780	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
DMI75_03785	COG0470	DNA polymerase III
DMI75_03805	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
DMI75_03935	COG3525	Glycosyl hydrolase, family 20, catalytic domain
DMI75_03940	COG2255	four-way junction helicase activity
DMI75_03945	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DMI75_03950	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
DMI75_03965	COG1215	transferase activity, transferring glycosyl groups
DMI75_03970	COG1215	transferase activity, transferring glycosyl groups
DMI75_04005	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
DMI75_04020	COG0482	sulfurtransferase activity
DMI75_04025	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
DMI75_04050	COG2860	membrane
DMI75_04055	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
DMI75_04060	COG2001	Belongs to the MraZ family
DMI75_04065	COG0275	rRNA processing
DMI75_04075	COG0768	penicillin binding
DMI75_04080	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
DMI75_04085	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
DMI75_04090	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DMI75_04095	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
DMI75_04105	COG0772	Belongs to the SEDS family
DMI75_04110	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
DMI75_04115	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
DMI75_04120	COG1181	Belongs to the D-alanine--D-alanine ligase family
DMI75_04135	COG0860	N-Acetylmuramoyl-L-alanine amidase
DMI75_04140	COG0321	lipoyl(octanoyl) transferase activity
DMI75_04145	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
DMI75_04150	COG0066	3-isopropylmalate dehydratase activity
DMI75_04160	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DMI75_04170	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
DMI75_04180	COG3209	COG3209 Rhs family protein
DMI75_04200	COG4608	Belongs to the ABC transporter superfamily
DMI75_04210	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
DMI75_04220	COG0534	Mate efflux family protein
DMI75_04230	COG2877	3-deoxy-8-phosphooctulonate synthase activity
DMI75_04245	COG1137	ATPase activity
DMI75_04255	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
DMI75_04285	COG0017	Asparaginyl-tRNA synthetase
DMI75_04295	COG3118	belongs to the thioredoxin family
DMI75_04360	COG0583	DNA-binding transcription factor activity
DMI75_04365	COG2855	membrane
DMI75_04370	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
DMI75_04385	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DMI75_04395	COG0602	queuosine metabolic process
DMI75_04400	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
DMI75_04405	COG0217	transcriptional regulatory protein
DMI75_04415	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
DMI75_04420	COG4106	trans-aconitate 2-methyltransferase activity
DMI75_04425	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
DMI75_04425	COG4651	solute:proton antiporter activity
DMI75_04440	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
DMI75_04445	COG4864	UPF0365 protein
DMI75_04455	COG2022	thiamine diphosphate biosynthetic process
DMI75_04460	COG0531	amino acid
DMI75_04470	COG0628	permease
DMI75_04475	COG0019	diaminopimelate decarboxylase activity
DMI75_04485	COG3525	Glycosyl hydrolase, family 20, catalytic domain
DMI75_04490	COG0191	fructose-bisphosphate aldolase activity
DMI75_04540	COG3152	Membrane
DMI75_04545	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
DMI75_04555	COG1181	Belongs to the D-alanine--D-alanine ligase family
DMI75_04585	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DMI75_04590	COG0517	IMP dehydrogenase activity
DMI75_04590	COG0516	GMP reductase activity
DMI75_04595	COG0518	GMP synthase (glutamine-hydrolyzing) activity
DMI75_04595	COG0519	Catalyzes the synthesis of GMP from XMP
DMI75_04610	COG0546	phosphoglycolate phosphatase activity
DMI75_04625	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
DMI75_04640	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
DMI75_04645	COG0196	riboflavin kinase activity
DMI75_04650	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
DMI75_04660	COG1408	metallophosphoesterase
DMI75_04675	COG1216	Glycosyl transferase, family 2
DMI75_04675	COG1442	glycosyl transferase family 8
DMI75_04685	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DMI75_04690	COG1216	Glycosyl transferase, family 2
DMI75_04700	COG0297	glycogen (starch) synthase activity
DMI75_04710	COG2755	lipolytic protein G-D-S-L family
DMI75_04710	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
DMI75_04730	COG0490	domain, Protein
DMI75_04730	COG0471	metal ion transport
DMI75_04770	COG0588	phosphoglycerate mutase activity
DMI75_04775	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DMI75_04795	COG0477	Major facilitator Superfamily
DMI75_04800	COG1607	acyl-coa hydrolase
DMI75_04825	COG1028	Short-chain dehydrogenase reductase Sdr
DMI75_04830	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
DMI75_04860	COG1475	DNA binding
DMI75_04865	COG3969	phosphoadenosine phosphosulfate
DMI75_04880	COG0473	3-isopropylmalate dehydrogenase activity
DMI75_04895	COG0606	chelatase, subunit chli
DMI75_04905	COG2873	o-acetylhomoserine
DMI75_04915	COG0535	radical SAM domain protein
DMI75_04930	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
DMI75_04935	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
DMI75_04945	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
DMI75_04950	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
DMI75_04950	COG1013	pyruvate-flavodoxin oxidoreductase activity
DMI75_04950	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
DMI75_04950	COG0674	pyruvate-flavodoxin oxidoreductase activity
DMI75_04970	COG0107	imidazoleglycerol-phosphate synthase activity
DMI75_04985	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
DMI75_04995	COG1643	Atp-dependent helicase
DMI75_05000	COG0440	acetolactate synthase activity
DMI75_05005	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DMI75_05015	COG0445	tRNA wobble uridine modification
DMI75_05020	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DMI75_05020	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DMI75_05025	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
DMI75_05035	COG0592	DNA-directed DNA polymerase activity
DMI75_05095	COG1388	LysM domain
DMI75_05095	COG0791	NLP P60 protein
DMI75_05100	COG0084	hydrolase, TatD family'
DMI75_05110	COG3250	beta-galactosidase activity
DMI75_05130	COG2205	protein histidine kinase activity
DMI75_05135	COG0745	RESPONSE REGULATOR receiver
DMI75_05145	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
DMI75_05155	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
DMI75_05160	COG3345	alpha-galactosidase
DMI75_05165	COG0542	response to heat
DMI75_05205	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
DMI75_05220	COG1733	regulation of RNA biosynthetic process
DMI75_05225	COG0659	secondary active sulfate transmembrane transporter activity
DMI75_05230	COG0165	Argininosuccinate lyase
DMI75_05250	COG0148	phosphopyruvate hydratase activity
DMI75_05255	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
DMI75_05280	COG3481	metal-dependent phosphohydrolase, HD sub domain
DMI75_05290	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DMI75_05295	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
DMI75_05325	COG3345	alpha-galactosidase
DMI75_05370	COG1592	Rubrerythrin
DMI75_05380	COG1363	Peptidase, m42
DMI75_05385	COG3525	Glycosyl hydrolase, family 20, catalytic domain
DMI75_05395	COG1785	Belongs to the alkaline phosphatase family
DMI75_05400	COG1970	mechanosensitive ion channel activity
DMI75_05405	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DMI75_05415	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
DMI75_05420	COG0657	acetylesterase activity
DMI75_05420	COG2755	lipolytic protein G-D-S-L family
DMI75_05430	COG2217	Heavy metal translocating P-type atpase
DMI75_05435	COG0497	DNA recombination
DMI75_05440	COG0321	lipoyl(octanoyl) transferase activity
DMI75_05440	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
DMI75_05445	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
DMI75_05470	COG0508	dehydrogenase complex catalyzes the overall conversion of
DMI75_05475	COG0022	dehydrogenase e1 component
DMI75_05485	COG4978	Transcriptional regulator
DMI75_05485	COG0789	Transcriptional regulator
DMI75_05490	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DMI75_05495	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DMI75_05535	COG0656	L-ascorbic acid biosynthetic process
DMI75_05540	COG3409	Peptidoglycan-binding domain 1 protein
DMI75_05540	COG5632	N-Acetylmuramoyl-L-alanine amidase
DMI75_05545	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
DMI75_05575	COG1690	Belongs to the RtcB family
DMI75_05585	COG2814	Major facilitator Superfamily
DMI75_05590	COG2096	Adenosyltransferase
DMI75_05605	COG3209	COG3209 Rhs family protein
DMI75_05630	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DMI75_05640	COG0557	exoribonuclease II activity
DMI75_05645	COG0826	peptidase U32
DMI75_05650	COG0285	dihydrofolate synthase activity
DMI75_05665	COG0673	inositol 2-dehydrogenase activity
DMI75_05680	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
DMI75_05685	COG0737	Belongs to the 5'-nucleotidase family
DMI75_05695	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
DMI75_05700	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
DMI75_05715	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
DMI75_05720	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
DMI75_05725	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
DMI75_05730	COG0200	Binds to the 23S rRNA
DMI75_05735	COG0201	protein transport
DMI75_05740	COG0563	adenylate kinase activity
DMI75_05745	COG0024	Methionine aminopeptidase
DMI75_05760	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
DMI75_05770	COG1442	glycosyl transferase family 8
DMI75_05775	COG1442	glycosyl transferase family 8
DMI75_05785	COG1216	Glycosyl transferase, family 2
DMI75_05790	COG1216	Glycosyl transferase, family 2
DMI75_05795	COG1216	Glycosyl transferase, family 2
DMI75_05800	COG1216	Glycosyl transferase, family 2
DMI75_05805	COG0693	protein deglycase activity
DMI75_05810	COG0508	dehydrogenase complex catalyzes the overall conversion of
DMI75_05815	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
DMI75_05825	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
DMI75_05835	COG1966	Carbon starvation protein
DMI75_05845	COG3119	arylsulfatase activity
DMI75_05850	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
DMI75_05855	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
DMI75_05860	COG0195	Participates in both transcription termination and antitermination
DMI75_05865	COG0708	Exodeoxyribonuclease III
DMI75_05870	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
DMI75_05875	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
DMI75_05880	COG2006	4fe-4S ferredoxin, iron-sulfur binding domain protein
DMI75_05905	COG1716	ATPase activity
DMI75_05905	COG1131	(ABC) transporter
DMI75_05905	COG0842	Transport permease protein
DMI75_05925	COG0724	RNA recognition motif
DMI75_05930	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
DMI75_05955	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
DMI75_05960	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
DMI75_05965	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
DMI75_05970	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DMI75_05985	COG1490	D-aminoacyl-tRNA deacylase activity
DMI75_05990	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
DMI75_05995	COG1053	succinate dehydrogenase
DMI75_06040	COG1028	Short-chain dehydrogenase reductase Sdr
DMI75_06050	COG0488	(ABC) transporter
DMI75_06060	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
DMI75_06080	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DMI75_06090	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DMI75_06095	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
DMI75_06150	COG2267	carboxylic ester hydrolase activity
DMI75_06155	COG2095	MarC family integral membrane protein
DMI75_06205	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
DMI75_06210	COG0488	(ABC) transporter
DMI75_06220	COG0697	spore germination
DMI75_06230	COG0215	cysteine-tRNA ligase activity
DMI75_06235	COG3525	Glycosyl hydrolase, family 20, catalytic domain
DMI75_06240	COG3119	arylsulfatase activity
DMI75_06255	COG0481	GTPase activity
DMI75_06275	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
DMI75_06280	COG0085	RNA polymerase activity
DMI75_06285	COG0222	ribosome binding
DMI75_06290	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
DMI75_06295	COG0081	regulation of translation
DMI75_06300	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
DMI75_06305	COG0250	Participates in transcription elongation, termination and antitermination
DMI75_06320	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
DMI75_06330	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
DMI75_06335	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
DMI75_06340	COG0740	serine-type endopeptidase activity
DMI75_06345	COG0544	peptidyl-prolyl cis-trans isomerase activity
DMI75_06360	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
DMI75_06385	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DMI75_06445	COG2226	methyltransferase
DMI75_06450	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
DMI75_06455	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
DMI75_06470	COG1902	pentaerythritol trinitrate reductase activity
DMI75_06470	COG0446	pyridine nucleotide-disulphide oxidoreductase
DMI75_06480	COG3119	arylsulfatase activity
DMI75_06485	COG0514	ATP-dependent DNA helicase (RecQ)
DMI75_06505	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
DMI75_06510	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DMI75_06525	COG2217	Heavy metal translocating P-type atpase
DMI75_06575	COG1858	cytochrome C peroxidase
DMI75_06580	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
DMI75_06585	COG0590	tRNA wobble adenosine to inosine editing
DMI75_06590	COG1940	carbohydrate kinase activity
DMI75_06595	COG2217	Heavy metal translocating P-type atpase
DMI75_06600	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
DMI75_06605	COG0237	dephospho-CoA kinase activity
DMI75_06635	COG1363	Peptidase, m42
DMI75_06640	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
DMI75_06655	COG0006	proline dipeptidase activity
DMI75_06660	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
DMI75_06700	COG0745	RESPONSE REGULATOR receiver
DMI75_06705	COG0129	dihydroxy-acid dehydratase activity
DMI75_06735	COG1368	sulfuric ester hydrolase activity
DMI75_06780	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
DMI75_06785	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
DMI75_06810	COG0534	Mate efflux family protein
DMI75_06815	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
DMI75_06875	COG1881	PFAM PEBP family protein
DMI75_06910	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
DMI75_06915	COG1119	ATPase activity
DMI75_06920	COG2186	Transcriptional regulator
DMI75_06950	COG0148	phosphopyruvate hydratase activity
DMI75_06965	COG0436	Aminotransferase
DMI75_06985	COG3345	alpha-galactosidase
DMI75_06995	COG0227	Belongs to the bacterial ribosomal protein bL28 family
DMI75_07010	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
DMI75_07030	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
DMI75_07040	COG1199	ATP-dependent helicase activity
DMI75_07045	COG1122	ATPase activity
DMI75_07070	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
DMI75_07075	COG0598	Magnesium transport protein CorA
DMI75_07080	COG0359	binds to the 23S rRNA
DMI75_07085	COG0138	bifunctional purine biosynthesis protein purh
DMI75_07090	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
DMI75_07095	COG0736	holo-[acyl-carrier-protein] synthase activity
DMI75_07110	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
DMI75_07115	COG3409	Peptidoglycan-binding domain 1 protein
DMI75_07115	COG5632	N-Acetylmuramoyl-L-alanine amidase
DMI75_07120	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
DMI75_07130	COG0437	4 iron, 4 sulfur cluster binding
DMI75_07160	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
DMI75_07220	COG3568	Endonuclease Exonuclease Phosphatase
DMI75_07225	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
DMI75_07250	COG2003	Belongs to the UPF0758 family
DMI75_07255	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
DMI75_07255	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
DMI75_07260	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
DMI75_07265	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
DMI75_07270	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
DMI75_07280	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
DMI75_07285	COG0322	excinuclease ABC activity
DMI75_07290	COG0811	peptide transport
DMI75_07295	COG0848	biopolymer transport protein
DMI75_07305	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
DMI75_07315	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
DMI75_07340	COG0515	serine threonine protein kinase
DMI75_07340	COG3266	domain, Protein
DMI75_07355	COG0631	protein serine/threonine phosphatase activity
DMI75_07360	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DMI75_07365	COG0515	serine threonine protein kinase
DMI75_07365	COG2815	serine threonine protein kinase
DMI75_07380	COG0631	protein serine/threonine phosphatase activity
DMI75_07420	COG0706	membrane insertase activity
DMI75_07425	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
DMI75_07435	COG0230	Belongs to the bacterial ribosomal protein bL34 family
DMI75_07450	COG0259	pyridoxamine-phosphate oxidase activity
DMI75_07465	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
DMI75_07475	COG1760	l-serine dehydratase
DMI75_07480	COG0492	ferredoxin-NADP+ reductase activity
DMI75_07480	COG3118	belongs to the thioredoxin family
DMI75_07555	COG1408	metallophosphoesterase
DMI75_07565	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
DMI75_07570	COG0545	Peptidyl-prolyl cis-trans isomerase
DMI75_07585	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
DMI75_07595	COG0826	peptidase U32
DMI75_07605	COG1262	PFAM Formylglycine-generating sulfatase enzyme
DMI75_07635	COG0581	inorganic phosphate transmembrane transporter activity
DMI75_07640	COG0573	inorganic phosphate transmembrane transporter activity
DMI75_07655	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
DMI75_07665	COG2017	converts alpha-aldose to the beta-anomer
DMI75_07680	COG0612	Peptidase, M16
DMI75_07695	COG0233	cytoplasmic translational termination
DMI75_07700	COG0528	UMP kinase activity
DMI75_07705	COG0668	transmembrane transport
DMI75_07715	COG0450	alkyl hydroperoxide reductase
DMI75_07720	COG0733	neurotransmitter:sodium symporter activity
DMI75_07740	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
DMI75_07750	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DMI75_07760	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DMI75_07765	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
DMI75_07785	COG2169	Transcriptional regulator
DMI75_07790	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
DMI75_07800	COG0842	Transport permease protein
DMI75_07805	COG0842	Transport permease protein
DMI75_07810	COG1131	(ABC) transporter
DMI75_07820	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
DMI75_07825	COG1183	phosphatidylcholine synthase activity
DMI75_07835	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
DMI75_07860	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
DMI75_07865	COG1028	Short-chain dehydrogenase reductase Sdr
DMI75_07885	COG0156	8-amino-7-oxononanoate synthase activity
DMI75_07915	COG3209	COG3209 Rhs family protein
DMI75_07940	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
DMI75_07945	COG0124	histidyl-tRNA synthetase
DMI75_07955	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
DMI75_07960	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
DMI75_07965	COG0298	carbon dioxide binding
DMI75_07985	COG0438	transferase activity, transferring glycosyl groups
DMI75_07990	COG0443	Heat shock 70 kDa protein
DMI75_07995	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
DMI75_08000	COG0459	protein refolding
DMI75_08060	COG0632	four-way junction helicase activity
DMI75_08070	COG0126	phosphoglycerate kinase activity
DMI75_08080	COG1082	Xylose isomerase domain protein TIM barrel
DMI75_08090	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
DMI75_08100	COG2271	Major facilitator Superfamily
DMI75_08105	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
DMI75_08115	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
DMI75_08125	COG0037	tRNA processing
DMI75_08130	COG0254	rRNA binding
DMI75_08175	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
DMI75_08180	COG0039	L-malate dehydrogenase activity
DMI75_08205	COG0778	Nitroreductase
DMI75_08210	COG0564	pseudouridine synthase activity
DMI75_08225	COG1335	isochorismatase
DMI75_08255	COG1126	abc transporter atp-binding protein
DMI75_08260	COG0765	amino acid transport
DMI75_08265	COG1216	Glycosyl transferase, family 2
DMI75_08280	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
DMI75_08285	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
DMI75_08295	COG1596	polysaccharide export
DMI75_08300	COG0489	protein tyrosine kinase activity
DMI75_08300	COG3206	protein involved in exopolysaccharide biosynthesis
DMI75_08305	COG0438	transferase activity, transferring glycosyl groups
DMI75_08315	COG1215	transferase activity, transferring glycosyl groups
DMI75_08340	COG0438	transferase activity, transferring glycosyl groups
DMI75_08345	COG1216	Glycosyl transferase, family 2
DMI75_08350	COG0438	transferase activity, transferring glycosyl groups
DMI75_08355	COG1442	glycosyl transferase family 8
DMI75_08355	COG1216	Glycosyl transferase, family 2
DMI75_08360	COG0438	transferase activity, transferring glycosyl groups
DMI75_08365	COG1216	Glycosyl transferase, family 2
DMI75_08385	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
DMI75_08390	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
DMI75_08410	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
DMI75_08445	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
DMI75_08450	COG1872	DUF167
DMI75_08455	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
DMI75_08460	COG0484	heat shock protein binding
DMI75_08465	COG1385	rRNA (uridine-N3-)-methyltransferase activity
DMI75_08475	COG5434	Belongs to the glycosyl hydrolase 28 family
DMI75_08490	COG0277	FAD linked oxidase domain protein
DMI75_08515	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
DMI75_08520	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
DMI75_08530	COG0131	Imidazoleglycerol-phosphate dehydratase
DMI75_08535	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
DMI75_08545	COG0360	Binds together with S18 to 16S ribosomal RNA
DMI75_08555	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
DMI75_08570	COG1686	Belongs to the peptidase S11 family
DMI75_08575	COG0205	6-phosphofructokinase activity
DMI75_08585	COG0428	transporter
DMI75_08590	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DMI75_08605	COG3977	Valine--pyruvate aminotransferase
DMI75_08610	COG1561	YicC-like family, N-terminal region
DMI75_08635	COG3273	potassium ion transport
DMI75_08635	COG0471	metal ion transport
DMI75_08640	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DMI75_08655	COG1575	Belongs to the MenA family. Type 1 subfamily
DMI75_08690	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DMI75_08690	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DMI75_08715	COG0202	RNA polymerase activity
DMI75_08720	COG0203	ribosomal protein L17
DMI75_08725	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
DMI75_08740	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DMI75_08835	COG0667	Aldo Keto reductase
DMI75_08840	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
DMI75_08845	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
DMI75_08850	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
DMI75_08855	COG0134	indole-3-glycerol-phosphate synthase activity
DMI75_08860	COG0135	phosphoribosylanthranilate isomerase activity
DMI75_08870	COG0159	tryptophan synthase activity
DMI75_08895	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
DMI75_08900	COG0257	Belongs to the bacterial ribosomal protein bL36 family
DMI75_08925	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
DMI75_08955	COG0561	phosphatase activity
DMI75_08965	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DMI75_08970	COG2223	nitrite transmembrane transporter activity
DMI75_08990	COG0556	nucleotide-excision repair
DMI75_09000	COG0291	Belongs to the bacterial ribosomal protein bL35 family
DMI75_09005	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
DMI75_09030	COG1074	ATP-dependent DNA helicase activity
DMI75_09040	COG0697	spore germination
DMI75_09050	COG2373	Large extracellular alpha-helical protein
DMI75_09055	COG1979	alcohol dehydrogenase
DMI75_09195	COG0372	Belongs to the citrate synthase family
DMI75_09200	COG3647	Membrane
DMI75_09205	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
DMI75_09215	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
DMI75_09225	COG1187	pseudouridine synthase activity
DMI75_09235	COG0105	UTP biosynthetic process
DMI75_09240	COG1215	transferase activity, transferring glycosyl groups
DMI75_09245	COG0463	Glycosyl transferase, family 2
DMI75_09255	COG1459	type II secretion system
DMI75_09260	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
DMI75_09290	COG3468	outer membrane autotransporter barrel domain protein
DMI75_09300	COG0728	peptidoglycan biosynthetic process
DMI75_09305	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
DMI75_09305	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
DMI75_09315	COG1649	PFAM Uncharacterised BCR, COG1649
DMI75_09320	COG1691	(AIR) carboxylase
DMI75_09325	COG1606	tRNA processing
DMI75_09330	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
DMI75_09335	COG0142	geranyltranstransferase activity
DMI75_09355	COG1162	GTPase activity
DMI75_09375	COG2151	metal-sulfur cluster biosynthetic enzyme
DMI75_09390	COG1007	ATP synthesis coupled electron transport
DMI75_09395	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DMI75_09405	COG0713	ATP synthesis coupled electron transport
DMI75_09410	COG0839	Belongs to the complex I subunit 6 family
DMI75_09420	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
DMI75_09425	COG1034	ATP synthesis coupled electron transport
DMI75_09430	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
DMI75_09435	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
DMI75_09440	COG0649	NAD binding
DMI75_09445	COG0726	polysaccharide deacetylase
DMI75_09455	COG0307	riboflavin synthase, alpha
DMI75_09460	COG2264	protein methyltransferase activity
DMI75_09470	COG1640	4-alpha-glucanotransferase
DMI75_09480	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DMI75_09485	COG1030	water channel activity
DMI75_09490	COG0358	DNA primase activity
DMI75_09495	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
DMI75_09500	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
DMI75_09525	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
DMI75_09530	COG0793	Belongs to the peptidase S41A family
DMI75_09540	COG1643	Atp-dependent helicase
DMI75_09565	COG1450	Type ii and iii secretion system protein
DMI75_09580	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
DMI75_09605	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
DMI75_09610	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
DMI75_09620	COG0268	Binds directly to 16S ribosomal RNA
DMI75_09625	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DMI75_09630	COG0028	Belongs to the TPP enzyme family
DMI75_09650	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
DMI75_09655	COG0495	leucyl-tRNA aminoacylation
DMI75_09660	COG3119	arylsulfatase activity
DMI75_09680	COG1166	arginine decarboxylase activity
DMI75_09695	COG3250	beta-galactosidase activity
DMI75_09700	COG3250	beta-galactosidase activity
DMI75_09705	COG3250	beta-galactosidase activity
DMI75_09710	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
DMI75_09715	COG3525	Glycosyl hydrolase, family 20, catalytic domain
DMI75_09720	COG1335	isochorismatase
DMI75_09730	COG1574	metal-dependent hydrolase with the TIM-barrel fold
DMI75_09750	COG0205	6-phosphofructokinase activity
DMI75_09810	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
DMI75_09815	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
DMI75_09820	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
DMI75_09835	COG4771	TonB-dependent receptor
DMI75_09840	COG0747	negative chemotaxis
DMI75_09855	COG0402	S-adenosylhomocysteine deaminase activity
DMI75_09860	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DMI75_09875	COG0508	dehydrogenase complex catalyzes the overall conversion of
DMI75_09885	COG1294	oxidase, subunit
DMI75_09890	COG1271	oxidase subunit
DMI75_09900	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DMI75_09920	COG1846	Transcriptional regulator
DMI75_09955	COG2949	membrane
DMI75_09965	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
DMI75_09975	COG0489	protein tyrosine kinase activity
DMI75_10015	COG0438	transferase activity, transferring glycosyl groups
DMI75_10035	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
DMI75_10035	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
DMI75_10070	COG0514	ATP-dependent DNA helicase (RecQ)
DMI75_10095	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
DMI75_10100	COG0045	succinate-CoA ligase (ADP-forming) activity
DMI75_10105	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
DMI75_10135	COG1570	exodeoxyribonuclease VII activity
DMI75_10165	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DMI75_10170	COG2205	protein histidine kinase activity
DMI75_10185	COG0113	porphobilinogen synthase activity
DMI75_10200	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
DMI75_10220	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
DMI75_10235	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
DMI75_10250	COG4106	trans-aconitate 2-methyltransferase activity
DMI75_10265	COG3475	LICD family
DMI75_10270	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
DMI75_10280	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DMI75_10285	COG3475	LICD family
DMI75_10290	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
DMI75_10300	COG2166	iron-sulfur cluster assembly
DMI75_10305	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
DMI75_10315	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DMI75_10320	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
DMI75_10325	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
DMI75_10330	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DMI75_10335	COG1131	(ABC) transporter
DMI75_10350	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
DMI75_10365	COG1215	transferase activity, transferring glycosyl groups
DMI75_10375	COG2967	ApaG domain
DMI75_10380	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
DMI75_10385	COG1522	sequence-specific DNA binding
DMI75_10390	COG0436	Aminotransferase
DMI75_10405	COG0423	glycine-tRNA ligase activity
DMI75_10445	COG1518	maintenance of DNA repeat elements
DMI75_10515	COG0586	Pfam SNARE associated Golgi protein
DMI75_10520	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
DMI75_10525	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
DMI75_10545	COG0038	chloride channel
DMI75_10560	COG4112	unkown
DMI75_10575	COG1538	Outer membrane efflux protein
DMI75_10585	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DMI75_10595	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DMI75_10610	COG3209	COG3209 Rhs family protein
DMI75_10630	COG0489	protein tyrosine kinase activity
DMI75_10635	COG0534	Mate efflux family protein
DMI75_10665	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DMI75_10670	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
DMI75_10685	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DMI75_10700	COG0418	dihydroorotase activity
DMI75_10705	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DMI75_10710	COG0513	Belongs to the DEAD box helicase family
DMI75_10715	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
DMI75_10740	COG2015	COG2015, Alkyl sulfatase and related hydrolases
DMI75_10750	COG1703	isobutyryl-CoA mutase activity
DMI75_10785	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
DMI75_10790	COG0352	thiamine-phosphate diphosphorylase activity
DMI75_10810	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
DMI75_10815	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
DMI75_10820	COG0326	Molecular chaperone. Has ATPase activity
DMI75_10835	COG3059	membrane
DMI75_10850	COG0072	phenylalanine-tRNA ligase activity
DMI75_10850	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DMI75_10865	COG3033	Beta-eliminating lyase
DMI75_10895	COG2818	Glycosylase
DMI75_10900	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
DMI75_10935	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
DMI75_10935	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
DMI75_10940	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
DMI75_10950	COG0166	Belongs to the GPI family
DMI75_10960	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DMI75_10960	COG0574	Belongs to the PEP-utilizing enzyme family
DMI75_10970	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
DMI75_10980	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
DMI75_10990	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DMI75_11000	COG5522	Integral membrane protein (intg_mem_TP0381)
DMI75_11020	COG0527	aspartate kinase activity
DMI75_11025	COG0460	homoserine dehydrogenase
DMI75_11040	COG3610	response to peptide
DMI75_11045	COG2966	Psort location CytoplasmicMembrane, score
DMI75_11050	COG1410	methionine synthase
DMI75_11050	COG0646	methionine synthase
DMI75_11090	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
DMI75_11095	COG0519	Catalyzes the synthesis of GMP from XMP
DMI75_11095	COG0518	GMP synthase (glutamine-hydrolyzing) activity
DMI75_11115	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
DMI75_11115	COG0512	Glutamine amidotransferase of anthranilate synthase
DMI75_11120	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
DMI75_11140	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DMI75_11175	COG2195	Cleaves the N-terminal amino acid of tripeptides
DMI75_11180	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
DMI75_11200	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DMI75_11200	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DMI75_11215	COG0037	tRNA processing
DMI75_11215	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
DMI75_11230	COG1247	-acetyltransferase
DMI75_11270	COG0815	Transfers the fatty acyl group on membrane lipoproteins
DMI75_11280	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
DMI75_11285	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
DMI75_11285	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
DMI75_11295	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
DMI75_11305	COG1454	alcohol dehydrogenase
DMI75_11315	COG4974	Belongs to the 'phage' integrase family
DMI75_11340	COG1408	metallophosphoesterase
DMI75_11350	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
DMI75_11365	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
DMI75_11375	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
DMI75_11390	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
DMI75_11415	COG5002	protein histidine kinase activity
DMI75_11420	COG0745	RESPONSE REGULATOR receiver
DMI75_11435	COG1968	undecaprenyl-diphosphatase activity
DMI75_11440	COG0805	protein transport
DMI75_11445	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DMI75_11445	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
DMI75_11455	COG0668	transmembrane transport
DMI75_11460	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
DMI75_11465	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
DMI75_11470	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
DMI75_11475	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
DMI75_11480	COG0456	acetyltransferase
DMI75_11500	COG0538	isocitrate dehydrogenase activity
DMI75_11515	COG3258	Cytochrome c
DMI75_11540	COG1169	isochorismate synthase
DMI75_11560	COG0640	Transcriptional regulator
DMI75_11570	COG0242	peptide deformylase activity
DMI75_11580	COG0811	peptide transport
DMI75_11595	COG0151	Belongs to the GarS family
DMI75_11600	COG3738	Protein conserved in bacteria
DMI75_11605	COG2759	Belongs to the formate--tetrahydrofolate ligase family
DMI75_11610	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
DMI75_11625	COG0601	transmembrane transport
DMI75_11630	COG4239	(ABC) transporter, permease
DMI75_11640	COG0444	Belongs to the ABC transporter superfamily
DMI75_11645	COG4608	Belongs to the ABC transporter superfamily
DMI75_11650	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
DMI75_11670	COG0697	spore germination
DMI75_11675	COG2132	Multicopper oxidase
DMI75_11680	COG0232	Belongs to the dGTPase family. Type 2 subfamily
DMI75_11690	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DMI75_11715	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
DMI75_11750	COG0738	Major facilitator superfamily
DMI75_11795	COG1741	Belongs to the pirin family
DMI75_11815	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
DMI75_11835	COG0363	glucosamine-6-phosphate deaminase activity
DMI75_11845	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
DMI75_11850	COG1837	Belongs to the UPF0109 family
DMI75_11875	COG1091	dTDP-4-dehydrorhamnose reductase activity
DMI75_11920	COG0789	Transcriptional regulator
DMI75_11935	COG1408	metallophosphoesterase
DMI75_11945	COG0656	L-ascorbic acid biosynthetic process
DMI75_11960	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
DMI75_11970	COG0697	spore germination
DMI75_11975	COG2311	Membrane
DMI75_12015	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
DMI75_12015	COG2755	lipolytic protein G-D-S-L family
DMI75_12040	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DMI75_12045	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DMI75_12085	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DMI75_12090	COG0154	amidase activity
DMI75_12095	COG0714	Associated with various cellular activities
DMI75_12110	COG2304	oxidoreductase activity
DMI75_12130	COG0656	L-ascorbic acid biosynthetic process
DMI75_12140	COG0110	maltose O-acetyltransferase activity
DMI75_12150	COG2207	Transcriptional regulator
DMI75_12160	COG1012	belongs to the aldehyde dehydrogenase family
DMI75_12180	COG0753	catalase activity
DMI75_12210	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
DMI75_12215	COG1592	Rubrerythrin
DMI75_12230	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
DMI75_12320	COG0489	protein tyrosine kinase activity
DMI75_12325	COG4464	protein tyrosine phosphatase activity
DMI75_12335	COG0438	transferase activity, transferring glycosyl groups
DMI75_12340	COG0438	transferase activity, transferring glycosyl groups
DMI75_12350	COG0438	transferase activity, transferring glycosyl groups
DMI75_12385	COG0110	maltose O-acetyltransferase activity
DMI75_12395	COG1216	Glycosyl transferase, family 2
DMI75_12405	COG1216	Glycosyl transferase, family 2
DMI75_12450	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
DMI75_12460	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
DMI75_12465	COG0280	phosphate acetyltransferase
DMI75_12465	COG0281	malic enzyme
DMI75_12485	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
DMI75_12500	COG0635	Involved in the biosynthesis of porphyrin-containing compound
DMI75_12505	COG0724	RNA recognition motif
DMI75_12515	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
DMI75_12520	COG1063	alcohol dehydrogenase
DMI75_12535	COG0714	Associated with various cellular activities
DMI75_12545	COG0193	aminoacyl-tRNA hydrolase activity
DMI75_12550	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DMI75_12570	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
DMI75_12595	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
DMI75_12610	COG0375	protein maturation
DMI75_12635	COG0778	Nitroreductase
DMI75_12640	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DMI75_12670	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
DMI75_12670	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
DMI75_12695	COG3525	Glycosyl hydrolase, family 20, catalytic domain
DMI75_12700	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
DMI75_12705	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
DMI75_12725	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DMI75_12730	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DMI75_12745	COG0318	PFAM AMP-dependent synthetase and ligase
DMI75_12770	COG0339	signal peptide processing
DMI75_12775	COG0110	maltose O-acetyltransferase activity
DMI75_12785	COG0018	arginyl-trna synthetase
DMI75_12820	COG4822	anaerobic cobalamin biosynthetic process
DMI75_12840	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
DMI75_12855	COG1797	cobyrinic acid a,c-diamide synthase activity
DMI75_12860	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
DMI75_12940	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
DMI75_12955	COG0653	protein targeting
DMI75_12960	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
DMI75_12960	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
DMI75_13005	COG0740	serine-type endopeptidase activity
DMI75_13175	COG0494	nUDIX hydrolase