locus-tag	class	description
GXM23_00010	COG1131	(ABC) transporter
GXM23_00030	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
GXM23_00035	COG0564	pseudouridine synthase activity
GXM23_00050	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
GXM23_00055	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
GXM23_00060	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GXM23_00090	COG0673	inositol 2-dehydrogenase activity
GXM23_00110	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
GXM23_00125	COG1971	Probably functions as a manganese efflux pump
GXM23_00150	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GXM23_00175	COG0442	prolyl-tRNA aminoacylation
GXM23_00195	COG0531	amino acid
GXM23_00200	COG2066	Belongs to the glutaminase family
GXM23_00210	COG1115	amino acid carrier protein
GXM23_00345	COG1783	phage Terminase large subunit
GXM23_00445	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
GXM23_00450	COG2890	protein-(glutamine-N5) methyltransferase activity
GXM23_00455	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
GXM23_00460	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
GXM23_00475	COG2226	methyltransferase
GXM23_00480	COG0534	Mate efflux family protein
GXM23_00520	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GXM23_00525	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
GXM23_00530	COG3525	Glycosyl hydrolase, family 20, catalytic domain
GXM23_00545	COG1121	(ABC) transporter
GXM23_00550	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GXM23_00555	COG3880	PFAM UvrB UvrC protein
GXM23_00560	COG3869	Catalyzes the specific phosphorylation of arginine residues in
GXM23_00565	COG0542	response to heat
GXM23_00580	COG0179	Fumarylacetoacetate (FAA) hydrolase
GXM23_00585	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GXM23_00600	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
GXM23_00600	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
GXM23_00615	COG0180	Tryptophanyl-tRNA synthetase
GXM23_00625	COG1692	metallophosphoesterase
GXM23_00630	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
GXM23_00645	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GXM23_00650	COG2816	NAD+ diphosphatase activity
GXM23_00655	COG0156	8-amino-7-oxononanoate synthase activity
GXM23_00670	COG3266	domain, Protein
GXM23_00670	COG0515	serine threonine protein kinase
GXM23_00680	COG4974	Belongs to the 'phage' integrase family
GXM23_00700	COG0326	Molecular chaperone. Has ATPase activity
GXM23_00735	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
GXM23_00745	COG3189	MarR family transcriptional regulator
GXM23_00755	COG0181	hydroxymethylbilane synthase activity
GXM23_00760	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
GXM23_00770	COG1469	GTP cyclohydrolase I activity
GXM23_00775	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
GXM23_00780	COG0267	Belongs to the bacterial ribosomal protein bL33 family
GXM23_00785	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
GXM23_00790	COG1940	carbohydrate kinase activity
GXM23_00805	COG0494	nUDIX hydrolase
GXM23_00810	COG1566	PFAM secretion protein HlyD family protein
GXM23_00815	COG1136	(ABC) transporter
GXM23_00815	COG0577	efflux transmembrane transporter activity
GXM23_00820	COG0577	efflux transmembrane transporter activity
GXM23_00820	COG1136	(ABC) transporter
GXM23_00825	COG1538	Outer membrane efflux protein
GXM23_00840	COG1720	tRNA m6t6A37 methyltransferase activity
GXM23_00845	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
GXM23_00850	COG0540	Belongs to the ATCase OTCase family
GXM23_00855	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
GXM23_00870	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
GXM23_00875	COG2957	Belongs to the agmatine deiminase family
GXM23_00885	COG0750	zinc metalloprotease
GXM23_00895	COG3119	arylsulfatase activity
GXM23_00905	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
GXM23_00905	COG1918	ferrous iron import across plasma membrane
GXM23_00955	COG1475	DNA binding
GXM23_00990	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GXM23_01005	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GXM23_01010	COG0601	transmembrane transport
GXM23_01065	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GXM23_01070	COG1132	(ABC) transporter
GXM23_01075	COG1132	(ABC) transporter
GXM23_01090	COG1127	ABC transporter
GXM23_01095	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
GXM23_01125	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GXM23_01140	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
GXM23_01145	COG0504	CTP synthase activity
GXM23_01150	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GXM23_01175	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GXM23_01185	COG1322	Protein conserved in bacteria
GXM23_01190	COG0546	phosphoglycolate phosphatase activity
GXM23_01195	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GXM23_01205	COG4591	ABC-type transport system involved in lipoprotein release permease component
GXM23_01205	COG4591	ABC-type transport system involved in lipoprotein release permease component
GXM23_01230	COG2755	lipolytic protein G-D-S-L family
GXM23_01230	COG0657	acetylesterase activity
GXM23_01235	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
GXM23_01255	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GXM23_01260	COG2267	carboxylic ester hydrolase activity
GXM23_01275	COG0335	large ribosomal subunit rRNA binding
GXM23_01285	COG0346	lactoylglutathione lyase activity
GXM23_01300	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
GXM23_01305	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
GXM23_01310	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
GXM23_01310	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
GXM23_01315	COG0427	acetyl-CoA hydrolase
GXM23_01325	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
GXM23_01335	COG0205	6-phosphofructokinase activity
GXM23_01350	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GXM23_01355	COG0028	Belongs to the TPP enzyme family
GXM23_01375	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
GXM23_01390	COG0471	metal ion transport
GXM23_01400	COG0351	phosphomethylpyrimidine kinase
GXM23_01455	COG1028	Short-chain dehydrogenase reductase Sdr
GXM23_01465	COG0242	peptide deformylase activity
GXM23_01470	COG1063	alcohol dehydrogenase
GXM23_01480	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GXM23_01485	COG1393	Belongs to the ArsC family
GXM23_01490	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
GXM23_01495	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GXM23_01505	COG1187	pseudouridine synthase activity
GXM23_01515	COG0336	Belongs to the RNA methyltransferase TrmD family
GXM23_01520	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
GXM23_01530	COG0539	negative regulation of cytoplasmic translation
GXM23_01575	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
GXM23_01580	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
GXM23_01585	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
GXM23_01590	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GXM23_01625	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GXM23_01705	COG3015	lipoprotein NlpE involved in copper resistance
GXM23_01775	COG0305	Participates in initiation and elongation during chromosome replication
GXM23_01880	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
GXM23_01880	COG0662	Cupin 2, conserved barrel domain protein
GXM23_01890	COG0416	fatty acid biosynthetic process
GXM23_01895	COG0333	Belongs to the bacterial ribosomal protein bL32 family
GXM23_01905	COG0537	adenosine 5'-monophosphoramidase activity
GXM23_01910	COG0009	L-threonylcarbamoyladenylate synthase
GXM23_01915	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
GXM23_01920	COG0228	four-way junction DNA binding
GXM23_01940	COG1862	Preprotein translocase
GXM23_01945	COG0343	queuine tRNA-ribosyltransferase activity
GXM23_01950	COG0220	tRNA (guanine-N7-)-methyltransferase activity
GXM23_01960	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
GXM23_01965	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
GXM23_01970	COG0776	regulation of translation
GXM23_02000	COG0811	peptide transport
GXM23_02015	COG3250	beta-galactosidase activity
GXM23_02020	COG0525	valine-tRNA ligase activity
GXM23_02030	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
GXM23_02035	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
GXM23_02040	COG0255	Belongs to the universal ribosomal protein uL29 family
GXM23_02045	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
GXM23_02050	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
GXM23_02055	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
GXM23_02065	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
GXM23_02070	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
GXM23_02075	COG0089	rRNA binding
GXM23_02080	COG0088	Forms part of the polypeptide exit tunnel
GXM23_02085	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
GXM23_02090	COG0051	transcription antitermination factor activity, RNA binding
GXM23_02095	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GXM23_02100	COG0049	tRNA binding
GXM23_02105	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
GXM23_02110	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
GXM23_02120	COG3852	Histidine kinase
GXM23_02125	COG2204	response regulator
GXM23_02135	COG1722	exodeoxyribonuclease VII activity
GXM23_02140	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
GXM23_02155	COG0795	lipopolysaccharide-transporting ATPase activity
GXM23_02160	COG1160	GTP binding
GXM23_02165	COG0444	Belongs to the ABC transporter superfamily
GXM23_02185	COG1136	(ABC) transporter
GXM23_02185	COG0577	efflux transmembrane transporter activity
GXM23_02195	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
GXM23_02240	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
GXM23_02245	COG0799	negative regulation of ribosome biogenesis
GXM23_02250	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GXM23_02300	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
GXM23_02315	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
GXM23_02325	COG0300	oxidoreductase activity
GXM23_02345	COG0038	chloride channel
GXM23_02355	COG3525	Glycosyl hydrolase, family 20, catalytic domain
GXM23_02370	COG0076	glutamate decarboxylase activity
GXM23_02385	COG0167	dihydroorotate dehydrogenase activity
GXM23_02390	COG0352	thiamine-phosphate diphosphorylase activity
GXM23_02410	COG1253	flavin adenine dinucleotide binding
GXM23_02415	COG1253	flavin adenine dinucleotide binding
GXM23_02425	COG1185	polyribonucleotide nucleotidyltransferase activity
GXM23_02430	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
GXM23_02435	COG0110	maltose O-acetyltransferase activity
GXM23_02460	COG0101	tRNA pseudouridine synthase activity
GXM23_02465	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
GXM23_02485	COG4968	Prepilin-type N-terminal cleavage methylation domain
GXM23_02500	COG3525	Glycosyl hydrolase, family 20, catalytic domain
GXM23_02505	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
GXM23_02525	COG1136	(ABC) transporter
GXM23_02530	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
GXM23_02540	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GXM23_02565	COG3525	Glycosyl hydrolase, family 20, catalytic domain
GXM23_02570	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
GXM23_02575	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
GXM23_02585	COG0828	Belongs to the bacterial ribosomal protein bS21 family
GXM23_02590	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
GXM23_02600	COG2814	Major facilitator Superfamily
GXM23_02610	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GXM23_02615	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GXM23_02615	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GXM23_02620	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
GXM23_02625	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GXM23_02630	COG0552	protein localization to endoplasmic reticulum
GXM23_02635	COG0820	rRNA (adenine-C2-)-methyltransferase activity
GXM23_02680	COG1546	Belongs to the CinA family
GXM23_02680	COG1058	Belongs to the CinA family
GXM23_02690	COG0456	acetyltransferase
GXM23_02715	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
GXM23_02720	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
GXM23_02725	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
GXM23_02730	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
GXM23_02745	COG0758	DNA mediated transformation
GXM23_02750	COG1686	Belongs to the peptidase S11 family
GXM23_02755	COG0012	GTP binding
GXM23_02760	COG0404	The glycine cleavage system catalyzes the degradation of glycine
GXM23_02770	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GXM23_02770	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GXM23_02790	COG3119	arylsulfatase activity
GXM23_02815	COG2259	Doxx family
GXM23_02820	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
GXM23_02850	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
GXM23_02870	COG2326	polyphosphate kinase activity
GXM23_02875	COG1349	DNA-binding transcription factor activity
GXM23_02890	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
GXM23_02895	COG1162	GTPase activity
GXM23_02910	COG0742	ribosomal rna small subunit methyltransferase
GXM23_02925	COG2326	polyphosphate kinase activity
GXM23_02935	COG5434	Belongs to the glycosyl hydrolase 28 family
GXM23_02945	COG1073	alpha beta
GXM23_02950	COG0802	atpase or kinase
GXM23_02955	COG0261	This protein binds to 23S rRNA in the presence of protein L20
GXM23_02960	COG0211	Belongs to the bacterial ribosomal protein bL27 family
GXM23_02965	COG0735	belongs to the Fur family
GXM23_02970	COG0396	ATPase activity
GXM23_02975	COG0719	Fe-S assembly protein
GXM23_02980	COG0719	Fe-S assembly protein
GXM23_02995	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
GXM23_03035	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
GXM23_03055	COG0355	proton-transporting ATP synthase activity, rotational mechanism
GXM23_03060	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
GXM23_03065	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
GXM23_03070	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
GXM23_03075	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GXM23_03080	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
GXM23_03090	COG0356	it plays a direct role in the translocation of protons across the membrane
GXM23_03155	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
GXM23_03185	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
GXM23_03190	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
GXM23_03195	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
GXM23_03205	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
GXM23_03215	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GXM23_03220	COG0047	phosphoribosylformylglycinamidine synthase activity
GXM23_03230	COG1363	Peptidase, m42
GXM23_03245	COG1077	Cell shape determining protein MreB Mrl
GXM23_03250	COG1530	ribonuclease E activity
GXM23_03270	COG0848	biopolymer transport protein
GXM23_03285	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
GXM23_03300	COG0134	indole-3-glycerol-phosphate synthase activity
GXM23_03305	COG0792	nuclease activity
GXM23_03315	COG1253	flavin adenine dinucleotide binding
GXM23_03325	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
GXM23_03330	COG0137	argininosuccinate synthase activity
GXM23_03345	COG0149	triose-phosphate isomerase activity
GXM23_03380	COG1040	competence protein
GXM23_03390	COG3956	TIGRFAM MazG family protein
GXM23_03410	COG1663	tetraacyldisaccharide 4'-kinase activity
GXM23_03415	COG0612	Peptidase, M16
GXM23_03440	COG0673	inositol 2-dehydrogenase activity
GXM23_03445	COG3034	peptidoglycan biosynthetic process
GXM23_03465	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
GXM23_03470	COG0424	maF-like protein
GXM23_03475	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
GXM23_03505	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
GXM23_03515	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
GXM23_03525	COG0571	ribonuclease III activity
GXM23_03535	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
GXM23_03605	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
GXM23_03620	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
GXM23_03640	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
GXM23_03655	COG2226	methyltransferase
GXM23_03665	COG2076	Multidrug Resistance protein
GXM23_03720	COG2255	four-way junction helicase activity
GXM23_03725	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GXM23_03730	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
GXM23_03735	COG1215	transferase activity, transferring glycosyl groups
GXM23_03745	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
GXM23_03755	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
GXM23_03765	COG0438	transferase activity, transferring glycosyl groups
GXM23_03790	COG0463	Glycosyl transferase, family 2
GXM23_03790	COG1216	Glycosyl transferase, family 2
GXM23_03820	COG1053	succinate dehydrogenase
GXM23_03825	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
GXM23_03865	COG1490	D-aminoacyl-tRNA deacylase activity
GXM23_03880	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GXM23_03885	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
GXM23_03895	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
GXM23_03915	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GXM23_03920	COG0724	RNA recognition motif
GXM23_03940	COG1716	ATPase activity
GXM23_03940	COG0842	Transport permease protein
GXM23_03940	COG1131	(ABC) transporter
GXM23_03950	COG2006	4fe-4S ferredoxin, iron-sulfur binding domain protein
GXM23_03955	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
GXM23_03960	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
GXM23_03965	COG0708	Exodeoxyribonuclease III
GXM23_03970	COG0195	Participates in both transcription termination and antitermination
GXM23_03975	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
GXM23_03980	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
GXM23_03990	COG3119	arylsulfatase activity
GXM23_04005	COG1966	Carbon starvation protein
GXM23_04015	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GXM23_04020	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
GXM23_04025	COG0508	dehydrogenase complex catalyzes the overall conversion of
GXM23_04030	COG0693	protein deglycase activity
GXM23_04035	COG1216	Glycosyl transferase, family 2
GXM23_04050	COG1216	Glycosyl transferase, family 2
GXM23_04060	COG1216	Glycosyl transferase, family 2
GXM23_04070	COG1442	glycosyl transferase family 8
GXM23_04075	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
GXM23_04090	COG0024	Methionine aminopeptidase
GXM23_04095	COG0563	adenylate kinase activity
GXM23_04100	COG0201	protein transport
GXM23_04105	COG0200	Binds to the 23S rRNA
GXM23_04110	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
GXM23_04115	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
GXM23_04120	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
GXM23_04135	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
GXM23_04140	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
GXM23_04150	COG0737	Belongs to the 5'-nucleotidase family
GXM23_04155	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GXM23_04160	COG0673	inositol 2-dehydrogenase activity
GXM23_04175	COG0285	dihydrofolate synthase activity
GXM23_04180	COG0826	peptidase U32
GXM23_04195	COG0557	exoribonuclease II activity
GXM23_04205	COG2096	Adenosyltransferase
GXM23_04215	COG2814	Major facilitator Superfamily
GXM23_04225	COG1690	Belongs to the RtcB family
GXM23_04250	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
GXM23_04255	COG5632	N-Acetylmuramoyl-L-alanine amidase
GXM23_04255	COG3409	Peptidoglycan-binding domain 1 protein
GXM23_04300	COG2738	Putative neutral zinc metallopeptidase
GXM23_04310	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GXM23_04315	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GXM23_04320	COG0789	Transcriptional regulator
GXM23_04325	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
GXM23_04330	COG0022	dehydrogenase e1 component
GXM23_04335	COG0508	dehydrogenase complex catalyzes the overall conversion of
GXM23_04365	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
GXM23_04370	COG0321	lipoyl(octanoyl) transferase activity
GXM23_04370	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
GXM23_04375	COG0497	DNA recombination
GXM23_04380	COG2217	Heavy metal translocating P-type atpase
GXM23_04390	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
GXM23_04400	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GXM23_04405	COG1970	mechanosensitive ion channel activity
GXM23_04410	COG1785	Belongs to the alkaline phosphatase family
GXM23_04420	COG3525	Glycosyl hydrolase, family 20, catalytic domain
GXM23_04425	COG1363	Peptidase, m42
GXM23_04435	COG1592	Rubrerythrin
GXM23_04440	COG2194	sulfuric ester hydrolase activity
GXM23_04465	COG0471	metal ion transport
GXM23_04480	COG0490	domain, Protein
GXM23_04480	COG2985	domain, Protein
GXM23_04510	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GXM23_04515	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GXM23_04525	COG3481	metal-dependent phosphohydrolase, HD sub domain
GXM23_04535	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
GXM23_04540	COG0148	phosphopyruvate hydratase activity
GXM23_04555	COG0165	Argininosuccinate lyase
GXM23_04560	COG0659	secondary active sulfate transmembrane transporter activity
GXM23_04570	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
GXM23_04615	COG0542	response to heat
GXM23_04640	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
GXM23_04650	COG0745	RESPONSE REGULATOR receiver
GXM23_04655	COG2205	protein histidine kinase activity
GXM23_04670	COG3250	beta-galactosidase activity
GXM23_04680	COG0084	hydrolase, TatD family'
GXM23_04685	COG1388	LysM domain
GXM23_04685	COG0791	NLP P60 protein
GXM23_04710	COG0592	DNA-directed DNA polymerase activity
GXM23_04720	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
GXM23_04725	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GXM23_04725	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GXM23_04730	COG0445	tRNA wobble uridine modification
GXM23_04740	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GXM23_04745	COG0440	acetolactate synthase activity
GXM23_04750	COG1643	Atp-dependent helicase
GXM23_04760	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GXM23_04770	COG0107	imidazoleglycerol-phosphate synthase activity
GXM23_04780	COG1733	regulation of RNA biosynthetic process
GXM23_04790	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
GXM23_04790	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
GXM23_04790	COG0674	pyruvate-flavodoxin oxidoreductase activity
GXM23_04790	COG1013	pyruvate-flavodoxin oxidoreductase activity
GXM23_04795	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
GXM23_04805	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
GXM23_04810	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
GXM23_04825	COG0535	radical SAM domain protein
GXM23_04835	COG2873	o-acetylhomoserine
GXM23_04860	COG0473	3-isopropylmalate dehydrogenase activity
GXM23_04875	COG3969	phosphoadenosine phosphosulfate
GXM23_04880	COG1475	DNA binding
GXM23_04895	COG1525	nuclease
GXM23_04905	COG1028	Short-chain dehydrogenase reductase Sdr
GXM23_04915	COG1607	acyl-coa hydrolase
GXM23_04920	COG0477	Major facilitator Superfamily
GXM23_04930	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GXM23_04935	COG0588	phosphoglycerate mutase activity
GXM23_04970	COG0490	domain, Protein
GXM23_04970	COG0471	metal ion transport
GXM23_04985	COG2755	lipolytic protein G-D-S-L family
GXM23_04985	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
GXM23_05005	COG1216	Glycosyl transferase, family 2
GXM23_05010	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GXM23_05020	COG1442	glycosyl transferase family 8
GXM23_05020	COG1216	Glycosyl transferase, family 2
GXM23_05030	COG1408	metallophosphoesterase
GXM23_05045	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
GXM23_05050	COG0196	riboflavin kinase activity
GXM23_05055	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
GXM23_05070	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GXM23_05090	COG0546	phosphoglycolate phosphatase activity
GXM23_05100	COG0518	GMP synthase (glutamine-hydrolyzing) activity
GXM23_05100	COG0519	Catalyzes the synthesis of GMP from XMP
GXM23_05105	COG0517	IMP dehydrogenase activity
GXM23_05105	COG0516	GMP reductase activity
GXM23_05110	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GXM23_05140	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
GXM23_05175	COG0191	fructose-bisphosphate aldolase activity
GXM23_05180	COG0019	diaminopimelate decarboxylase activity
GXM23_05185	COG0628	permease
GXM23_05195	COG0531	amino acid
GXM23_05200	COG2022	thiamine diphosphate biosynthetic process
GXM23_05210	COG4864	UPF0365 protein
GXM23_05215	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
GXM23_05225	COG4651	solute:proton antiporter activity
GXM23_05225	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
GXM23_05230	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
GXM23_05235	COG0217	transcriptional regulatory protein
GXM23_05240	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
GXM23_05245	COG0602	queuosine metabolic process
GXM23_05255	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GXM23_05265	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
GXM23_05270	COG2855	membrane
GXM23_05275	COG0583	DNA-binding transcription factor activity
GXM23_05320	COG3118	belongs to the thioredoxin family
GXM23_05330	COG0017	Asparaginyl-tRNA synthetase
GXM23_05355	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GXM23_05365	COG1137	ATPase activity
GXM23_05380	COG2877	3-deoxy-8-phosphooctulonate synthase activity
GXM23_05395	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
GXM23_05400	COG4608	Belongs to the ABC transporter superfamily
GXM23_05405	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
GXM23_05415	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GXM23_05425	COG0066	3-isopropylmalate dehydratase activity
GXM23_05430	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
GXM23_05435	COG0321	lipoyl(octanoyl) transferase activity
GXM23_05440	COG0860	N-Acetylmuramoyl-L-alanine amidase
GXM23_05445	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
GXM23_05455	COG1181	Belongs to the D-alanine--D-alanine ligase family
GXM23_05460	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GXM23_05465	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
GXM23_05470	COG0772	Belongs to the SEDS family
GXM23_05480	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
GXM23_05485	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GXM23_05490	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
GXM23_05495	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
GXM23_05500	COG0768	penicillin binding
GXM23_05510	COG0275	rRNA processing
GXM23_05515	COG2001	Belongs to the MraZ family
GXM23_05520	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
GXM23_05525	COG2860	membrane
GXM23_05535	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
GXM23_05540	COG0482	sulfurtransferase activity
GXM23_05560	COG1028	Short-chain dehydrogenase reductase Sdr
GXM23_05570	COG0488	(ABC) transporter
GXM23_05580	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
GXM23_05590	COG1253	flavin adenine dinucleotide binding
GXM23_05595	COG1028	Short-chain dehydrogenase reductase Sdr
GXM23_05605	COG1073	alpha beta
GXM23_05615	COG0667	Aldo Keto reductase
GXM23_05670	COG2267	carboxylic ester hydrolase activity
GXM23_05675	COG2095	MarC family integral membrane protein
GXM23_05715	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GXM23_05720	COG0488	(ABC) transporter
GXM23_05730	COG0697	spore germination
GXM23_05740	COG0215	cysteine-tRNA ligase activity
GXM23_05750	COG3119	arylsulfatase activity
GXM23_05765	COG0481	GTPase activity
GXM23_05780	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
GXM23_05785	COG0085	RNA polymerase activity
GXM23_05790	COG0222	ribosome binding
GXM23_05795	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
GXM23_05800	COG0081	regulation of translation
GXM23_05805	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
GXM23_05810	COG0250	Participates in transcription elongation, termination and antitermination
GXM23_05825	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
GXM23_05835	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
GXM23_05845	COG0740	serine-type endopeptidase activity
GXM23_05850	COG0544	peptidyl-prolyl cis-trans isomerase activity
GXM23_05865	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
GXM23_05885	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GXM23_05925	COG2226	methyltransferase
GXM23_05930	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
GXM23_05935	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
GXM23_05950	COG0446	pyridine nucleotide-disulphide oxidoreductase
GXM23_05950	COG1902	pentaerythritol trinitrate reductase activity
GXM23_05960	COG3119	arylsulfatase activity
GXM23_05965	COG0514	ATP-dependent DNA helicase (RecQ)
GXM23_05985	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
GXM23_05990	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GXM23_06045	COG1858	cytochrome C peroxidase
GXM23_06050	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
GXM23_06055	COG0590	tRNA wobble adenosine to inosine editing
GXM23_06060	COG1940	carbohydrate kinase activity
GXM23_06065	COG2217	Heavy metal translocating P-type atpase
GXM23_06070	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
GXM23_06075	COG0237	dephospho-CoA kinase activity
GXM23_06105	COG1363	Peptidase, m42
GXM23_06110	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
GXM23_06120	COG0006	proline dipeptidase activity
GXM23_06125	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
GXM23_06150	COG5002	protein histidine kinase activity
GXM23_06155	COG0745	RESPONSE REGULATOR receiver
GXM23_06160	COG0129	dihydroxy-acid dehydratase activity
GXM23_06185	COG1368	sulfuric ester hydrolase activity
GXM23_06220	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GXM23_06225	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
GXM23_06245	COG0534	Mate efflux family protein
GXM23_06250	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GXM23_06265	COG1876	peptidase activity
GXM23_06325	COG3209	COG3209 Rhs family protein
GXM23_06405	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
GXM23_06410	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
GXM23_06415	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
GXM23_06420	COG2205	protein histidine kinase activity
GXM23_06425	COG1262	PFAM Formylglycine-generating sulfatase enzyme
GXM23_06435	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GXM23_06455	COG0789	Transcriptional regulator
GXM23_06500	COG0714	Associated with various cellular activities
GXM23_06505	COG2311	Membrane
GXM23_06525	COG1090	epimerase
GXM23_06535	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
GXM23_06540	COG1119	ATPase activity
GXM23_06545	COG2186	Transcriptional regulator
GXM23_06555	COG3119	arylsulfatase activity
GXM23_06565	COG0148	phosphopyruvate hydratase activity
GXM23_06570	COG0436	Aminotransferase
GXM23_06575	COG1477	protein flavinylation
GXM23_06590	COG0227	Belongs to the bacterial ribosomal protein bL28 family
GXM23_06600	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
GXM23_06620	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
GXM23_06630	COG1199	ATP-dependent helicase activity
GXM23_06635	COG1122	ATPase activity
GXM23_06660	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
GXM23_06665	COG0598	Magnesium transport protein CorA
GXM23_06670	COG0359	binds to the 23S rRNA
GXM23_06675	COG0138	bifunctional purine biosynthesis protein purh
GXM23_06680	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
GXM23_06685	COG0736	holo-[acyl-carrier-protein] synthase activity
GXM23_06695	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
GXM23_06700	COG3409	Peptidoglycan-binding domain 1 protein
GXM23_06700	COG5632	N-Acetylmuramoyl-L-alanine amidase
GXM23_06705	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
GXM23_06715	COG0437	4 iron, 4 sulfur cluster binding
GXM23_06735	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
GXM23_06785	COG0284	orotidine-5'-phosphate decarboxylase activity
GXM23_06805	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
GXM23_06810	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
GXM23_06895	COG0305	Participates in initiation and elongation during chromosome replication
GXM23_07025	COG2003	Belongs to the UPF0758 family
GXM23_07030	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
GXM23_07030	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
GXM23_07035	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
GXM23_07040	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
GXM23_07045	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GXM23_07050	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
GXM23_07055	COG0322	excinuclease ABC activity
GXM23_07060	COG0811	peptide transport
GXM23_07065	COG0848	biopolymer transport protein
GXM23_07075	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
GXM23_07085	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
GXM23_07095	COG1482	cell wall glycoprotein biosynthetic process
GXM23_07105	COG1757	Na H antiporter
GXM23_07110	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GXM23_07115	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
GXM23_07120	COG0505	Belongs to the CarA family
GXM23_07125	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
GXM23_07140	COG0067	glutamate synthase
GXM23_07140	COG0069	glutamate synthase activity
GXM23_07140	COG0070	glutamate synthase
GXM23_07145	COG0706	membrane insertase activity
GXM23_07150	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
GXM23_07160	COG0230	Belongs to the bacterial ribosomal protein bL34 family
GXM23_07170	COG2755	lipolytic protein G-D-S-L family
GXM23_07170	COG0657	acetylesterase activity
GXM23_07180	COG0676	glucose-6-phosphate 1-epimerase activity
GXM23_07185	COG0259	pyridoxamine-phosphate oxidase activity
GXM23_07200	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
GXM23_07215	COG1760	l-serine dehydratase
GXM23_07220	COG0492	ferredoxin-NADP+ reductase activity
GXM23_07220	COG3118	belongs to the thioredoxin family
GXM23_07270	COG1408	metallophosphoesterase
GXM23_07280	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
GXM23_07285	COG0545	Peptidyl-prolyl cis-trans isomerase
GXM23_07300	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
GXM23_07310	COG0826	peptidase U32
GXM23_07320	COG1262	PFAM Formylglycine-generating sulfatase enzyme
GXM23_07340	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GXM23_07350	COG1116	anion transmembrane transporter activity
GXM23_07360	COG0529	Catalyzes the synthesis of activated sulfate
GXM23_07360	COG2895	sulfate adenylyltransferase (ATP) activity
GXM23_07365	COG0175	sulfate reduction
GXM23_07370	COG0175	sulfate reduction
GXM23_07390	COG0581	inorganic phosphate transmembrane transporter activity
GXM23_07395	COG0573	inorganic phosphate transmembrane transporter activity
GXM23_07405	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GXM23_07415	COG2017	converts alpha-aldose to the beta-anomer
GXM23_07430	COG0612	Peptidase, M16
GXM23_07480	COG0233	cytoplasmic translational termination
GXM23_07485	COG0528	UMP kinase activity
GXM23_07490	COG0668	transmembrane transport
GXM23_07495	COG0450	alkyl hydroperoxide reductase
GXM23_07500	COG0733	neurotransmitter:sodium symporter activity
GXM23_07515	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
GXM23_07525	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GXM23_07530	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GXM23_07535	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GXM23_07555	COG0842	Transport permease protein
GXM23_07560	COG0842	Transport permease protein
GXM23_07565	COG1131	(ABC) transporter
GXM23_07575	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GXM23_07580	COG1183	phosphatidylcholine synthase activity
GXM23_07590	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
GXM23_07600	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
GXM23_07605	COG1028	Short-chain dehydrogenase reductase Sdr
GXM23_07625	COG0156	8-amino-7-oxononanoate synthase activity
GXM23_07645	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
GXM23_07650	COG0124	histidyl-tRNA synthetase
GXM23_07655	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
GXM23_07660	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
GXM23_07665	COG0298	carbon dioxide binding
GXM23_07690	COG0438	transferase activity, transferring glycosyl groups
GXM23_07695	COG0443	Heat shock 70 kDa protein
GXM23_07700	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
GXM23_07705	COG0459	protein refolding
GXM23_07760	COG0632	four-way junction helicase activity
GXM23_07770	COG0126	phosphoglycerate kinase activity
GXM23_07780	COG1082	Xylose isomerase domain protein TIM barrel
GXM23_07785	COG4991	sh3 domain protein
GXM23_07785	COG0515	serine threonine protein kinase
GXM23_07785	COG3064	Membrane
GXM23_07790	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
GXM23_07800	COG2271	Major facilitator Superfamily
GXM23_07815	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
GXM23_07825	COG0037	tRNA processing
GXM23_07830	COG0254	rRNA binding
GXM23_07865	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
GXM23_07870	COG0039	L-malate dehydrogenase activity
GXM23_07890	COG0778	Nitroreductase
GXM23_07895	COG0564	pseudouridine synthase activity
GXM23_07915	COG1126	abc transporter atp-binding protein
GXM23_07920	COG0765	amino acid transport
GXM23_08025	COG2856	Zn peptidase
GXM23_08040	COG4085	toxin activity
GXM23_08040	COG0737	Belongs to the 5'-nucleotidase family
GXM23_08040	COG1525	nuclease
GXM23_08145	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
GXM23_08150	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
GXM23_08170	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
GXM23_08195	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
GXM23_08200	COG1872	DUF167
GXM23_08205	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
GXM23_08210	COG0484	heat shock protein binding
GXM23_08215	COG1385	rRNA (uridine-N3-)-methyltransferase activity
GXM23_08225	COG5434	Belongs to the glycosyl hydrolase 28 family
GXM23_08240	COG0277	FAD linked oxidase domain protein
GXM23_08265	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
GXM23_08270	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
GXM23_08280	COG0131	Imidazoleglycerol-phosphate dehydratase
GXM23_08285	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
GXM23_08290	COG0360	Binds together with S18 to 16S ribosomal RNA
GXM23_08295	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
GXM23_08310	COG1686	Belongs to the peptidase S11 family
GXM23_08315	COG0205	6-phosphofructokinase activity
GXM23_08325	COG0428	transporter
GXM23_08330	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GXM23_08345	COG3977	Valine--pyruvate aminotransferase
GXM23_08350	COG1561	YicC-like family, N-terminal region
GXM23_08360	COG3273	potassium ion transport
GXM23_08360	COG0471	metal ion transport
GXM23_08365	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GXM23_08380	COG1575	Belongs to the MenA family. Type 1 subfamily
GXM23_08385	COG0710	3-dehydroquinate dehydratase activity
GXM23_08415	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GXM23_08415	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GXM23_08435	COG0202	RNA polymerase activity
GXM23_08440	COG0203	ribosomal protein L17
GXM23_08445	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
GXM23_08455	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GXM23_08470	COG2885	chlorophyll binding
GXM23_08505	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GXM23_08545	COG0667	Aldo Keto reductase
GXM23_08550	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
GXM23_08565	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GXM23_08570	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
GXM23_08575	COG0134	indole-3-glycerol-phosphate synthase activity
GXM23_08580	COG0135	phosphoribosylanthranilate isomerase activity
GXM23_08590	COG0159	tryptophan synthase activity
GXM23_08605	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
GXM23_08610	COG0257	Belongs to the bacterial ribosomal protein bL36 family
GXM23_08620	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
GXM23_08650	COG0561	phosphatase activity
GXM23_08655	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GXM23_08660	COG2223	nitrite transmembrane transporter activity
GXM23_08685	COG1403	HNH endonuclease
GXM23_08690	COG0305	Participates in initiation and elongation during chromosome replication
GXM23_08800	COG0860	N-Acetylmuramoyl-L-alanine amidase
GXM23_08885	COG0863	Belongs to the N(4) N(6)-methyltransferase family
GXM23_08920	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
GXM23_08935	COG1715	Restriction endonuclease
GXM23_08955	COG2314	TM2 domain
GXM23_09020	COG0556	nucleotide-excision repair
GXM23_09025	COG0291	Belongs to the bacterial ribosomal protein bL35 family
GXM23_09030	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
GXM23_09035	COG0750	zinc metalloprotease
GXM23_09050	COG1074	ATP-dependent DNA helicase activity
GXM23_09060	COG0697	spore germination
GXM23_09065	COG2373	Large extracellular alpha-helical protein
GXM23_09070	COG1979	alcohol dehydrogenase
GXM23_09080	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
GXM23_09105	COG0372	Belongs to the citrate synthase family
GXM23_09120	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
GXM23_09130	COG1187	pseudouridine synthase activity
GXM23_09140	COG0105	UTP biosynthetic process
GXM23_09145	COG1215	transferase activity, transferring glycosyl groups
GXM23_09150	COG0463	Glycosyl transferase, family 2
GXM23_09160	COG1459	type II secretion system
GXM23_09165	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GXM23_09175	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GXM23_09190	COG0728	peptidoglycan biosynthetic process
GXM23_09195	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
GXM23_09195	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
GXM23_09205	COG1649	PFAM Uncharacterised BCR, COG1649
GXM23_09210	COG1691	(AIR) carboxylase
GXM23_09215	COG0037	tRNA processing
GXM23_09220	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
GXM23_09225	COG0142	geranyltranstransferase activity
GXM23_09240	COG2151	metal-sulfur cluster biosynthetic enzyme
GXM23_09260	COG1007	ATP synthesis coupled electron transport
GXM23_09265	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GXM23_09275	COG0713	ATP synthesis coupled electron transport
GXM23_09280	COG0839	Belongs to the complex I subunit 6 family
GXM23_09290	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
GXM23_09295	COG1034	ATP synthesis coupled electron transport
GXM23_09300	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
GXM23_09305	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
GXM23_09310	COG0649	NAD binding
GXM23_09320	COG0726	polysaccharide deacetylase
GXM23_09330	COG0307	riboflavin synthase, alpha
GXM23_09335	COG2264	protein methyltransferase activity
GXM23_09340	COG3210	domain, Protein
GXM23_09345	COG1640	4-alpha-glucanotransferase
GXM23_09355	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GXM23_09360	COG1030	water channel activity
GXM23_09365	COG0358	DNA primase activity
GXM23_09370	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GXM23_09375	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
GXM23_09390	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GXM23_09395	COG0793	Belongs to the peptidase S41A family
GXM23_09410	COG1643	Atp-dependent helicase
GXM23_09435	COG1450	Type ii and iii secretion system protein
GXM23_09450	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
GXM23_09470	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GXM23_09475	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
GXM23_09485	COG0268	Binds directly to 16S ribosomal RNA
GXM23_09490	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GXM23_09495	COG0028	Belongs to the TPP enzyme family
GXM23_09500	COG0688	phosphatidylethanolamine metabolic process
GXM23_09505	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
GXM23_09510	COG0495	leucyl-tRNA aminoacylation
GXM23_09515	COG3119	arylsulfatase activity
GXM23_09530	COG1166	arginine decarboxylase activity
GXM23_09540	COG3250	beta-galactosidase activity
GXM23_09545	COG3250	beta-galactosidase activity
GXM23_09550	COG3250	beta-galactosidase activity
GXM23_09555	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
GXM23_09560	COG3525	Glycosyl hydrolase, family 20, catalytic domain
GXM23_09570	COG0205	6-phosphofructokinase activity
GXM23_09620	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
GXM23_09625	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
GXM23_09630	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
GXM23_09640	COG4771	TonB-dependent receptor
GXM23_09665	COG0402	S-adenosylhomocysteine deaminase activity
GXM23_09670	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GXM23_09695	COG1294	oxidase, subunit
GXM23_09700	COG1271	oxidase subunit
GXM23_09710	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GXM23_09730	COG1846	Transcriptional regulator
GXM23_09760	COG2949	membrane
GXM23_09785	COG0514	ATP-dependent DNA helicase (RecQ)
GXM23_09800	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
GXM23_09805	COG0045	succinate-CoA ligase (ADP-forming) activity
GXM23_09810	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
GXM23_09870	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GXM23_09875	COG2205	protein histidine kinase activity
GXM23_09890	COG0113	porphobilinogen synthase activity
GXM23_09900	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
GXM23_09920	COG0732	type I restriction modification DNA specificity domain
GXM23_09935	COG0732	type I restriction modification DNA specificity domain
GXM23_09945	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
GXM23_09970	COG4106	trans-aconitate 2-methyltransferase activity
GXM23_09985	COG3475	LICD family
GXM23_09990	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
GXM23_10000	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GXM23_10005	COG3475	LICD family
GXM23_10010	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
GXM23_10020	COG2166	iron-sulfur cluster assembly
GXM23_10025	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
GXM23_10035	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GXM23_10040	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GXM23_10045	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
GXM23_10050	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GXM23_10055	COG1131	(ABC) transporter
GXM23_10070	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
GXM23_10085	COG1215	transferase activity, transferring glycosyl groups
GXM23_10095	COG2967	ApaG domain
GXM23_10105	COG1522	sequence-specific DNA binding
GXM23_10110	COG0436	Aminotransferase
GXM23_10125	COG0423	glycine-tRNA ligase activity
GXM23_10130	COG0656	L-ascorbic acid biosynthetic process
GXM23_10145	COG2304	oxidoreductase activity
GXM23_10160	COG0714	Associated with various cellular activities
GXM23_10165	COG0154	amidase activity
GXM23_10170	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GXM23_10205	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GXM23_10210	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GXM23_10220	COG2755	lipolytic protein G-D-S-L family
GXM23_10220	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
GXM23_10240	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
GXM23_10250	COG0656	L-ascorbic acid biosynthetic process
GXM23_10260	COG0667	Aldo Keto reductase
GXM23_10265	COG1408	metallophosphoesterase
GXM23_10285	COG2249	NAD(P)H dehydrogenase (quinone) activity
GXM23_10290	COG0789	Transcriptional regulator
GXM23_10305	COG0534	Mate efflux family protein
GXM23_10325	COG1091	dTDP-4-dehydrorhamnose reductase activity
GXM23_10340	COG1837	Belongs to the UPF0109 family
GXM23_10345	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
GXM23_10350	COG0363	glucosamine-6-phosphate deaminase activity
GXM23_10370	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
GXM23_10380	COG1741	Belongs to the pirin family
GXM23_10395	COG1070	Carbohydrate kinase
GXM23_10410	COG0738	Major facilitator superfamily
GXM23_10425	COG1595	DNA-templated transcription, initiation
GXM23_10445	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
GXM23_10470	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GXM23_10485	COG0232	Belongs to the dGTPase family. Type 2 subfamily
GXM23_10490	COG2132	Multicopper oxidase
GXM23_10495	COG0697	spore germination
GXM23_10505	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GXM23_10510	COG4608	Belongs to the ABC transporter superfamily
GXM23_10515	COG0444	Belongs to the ABC transporter superfamily
GXM23_10520	COG4166	transmembrane transport
GXM23_10525	COG4239	(ABC) transporter, permease
GXM23_10530	COG0601	transmembrane transport
GXM23_10550	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
GXM23_10555	COG2759	Belongs to the formate--tetrahydrofolate ligase family
GXM23_10560	COG3738	Protein conserved in bacteria
GXM23_10565	COG0151	Belongs to the GarS family
GXM23_10580	COG0811	peptide transport
GXM23_10590	COG0242	peptide deformylase activity
GXM23_10635	COG3258	Cytochrome c
GXM23_10650	COG3274	enterobacterial common antigen metabolic process
GXM23_10655	COG0538	isocitrate dehydrogenase activity
GXM23_10670	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
GXM23_10675	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
GXM23_10680	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
GXM23_10690	COG0668	transmembrane transport
GXM23_10695	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
GXM23_10695	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GXM23_10700	COG0805	protein transport
GXM23_10705	COG1968	undecaprenyl-diphosphatase activity
GXM23_10725	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
GXM23_10735	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
GXM23_10745	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
GXM23_10755	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
GXM23_10765	COG1408	metallophosphoesterase
GXM23_10790	COG4974	Belongs to the 'phage' integrase family
GXM23_10810	COG1454	alcohol dehydrogenase
GXM23_10815	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
GXM23_10825	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GXM23_10825	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
GXM23_10830	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
GXM23_10870	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GXM23_10880	COG4607	ABC-type enterochelin transport system periplasmic component
GXM23_10885	COG4604	ABC transporter, ATP-binding protein
GXM23_10890	COG4605	iron ion homeostasis
GXM23_10895	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GXM23_10930	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GXM23_10930	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GXM23_10945	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
GXM23_10950	COG2195	Cleaves the N-terminal amino acid of tripeptides
GXM23_10970	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GXM23_10990	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GXM23_11015	COG0519	Catalyzes the synthesis of GMP from XMP
GXM23_11015	COG0518	GMP synthase (glutamine-hydrolyzing) activity
GXM23_11020	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
GXM23_11055	COG1410	methionine synthase
GXM23_11055	COG0646	methionine synthase
GXM23_11060	COG2966	Psort location CytoplasmicMembrane, score
GXM23_11065	COG3610	response to peptide
GXM23_11070	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
GXM23_11085	COG4974	Belongs to the 'phage' integrase family
GXM23_11095	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
GXM23_11105	COG0460	homoserine dehydrogenase
GXM23_11110	COG0527	aspartate kinase activity
GXM23_11120	COG5522	Integral membrane protein (intg_mem_TP0381)
GXM23_11130	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GXM23_11135	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
GXM23_11140	COG1194	a g-specific adenine glycosylase
GXM23_11145	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
GXM23_11150	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GXM23_11150	COG0574	Belongs to the PEP-utilizing enzyme family
GXM23_11155	COG0166	Belongs to the GPI family
GXM23_11165	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
GXM23_11180	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
GXM23_11180	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
GXM23_11215	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
GXM23_11220	COG2818	Glycosylase
GXM23_11240	COG3033	Beta-eliminating lyase
GXM23_11255	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GXM23_11255	COG0072	phenylalanine-tRNA ligase activity
GXM23_11275	COG0326	Molecular chaperone. Has ATPase activity
GXM23_11280	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
GXM23_11290	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GXM23_11295	COG1959	2 iron, 2 sulfur cluster binding
GXM23_11310	COG0352	thiamine-phosphate diphosphorylase activity
GXM23_11315	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
GXM23_11340	COG1703	isobutyryl-CoA mutase activity
GXM23_11360	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
GXM23_11370	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GXM23_11375	COG0418	dihydroorotase activity
GXM23_11390	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GXM23_11410	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GXM23_11425	COG0534	Mate efflux family protein
GXM23_11430	COG0489	protein tyrosine kinase activity
GXM23_11440	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GXM23_11445	COG0339	signal peptide processing
GXM23_11450	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GXM23_11460	COG1538	Outer membrane efflux protein
GXM23_11475	COG4112	unkown
GXM23_11490	COG0038	chloride channel
GXM23_11500	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
GXM23_11505	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GXM23_11510	COG0586	Pfam SNARE associated Golgi protein
GXM23_11580	COG1012	belongs to the aldehyde dehydrogenase family
GXM23_11595	COG0753	catalase activity
GXM23_11605	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GXM23_11610	COG1592	Rubrerythrin
GXM23_11615	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GXM23_11635	COG0489	protein tyrosine kinase activity
GXM23_11645	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GXM23_11655	COG0438	transferase activity, transferring glycosyl groups
GXM23_11665	COG0438	transferase activity, transferring glycosyl groups
GXM23_11705	COG0110	maltose O-acetyltransferase activity
GXM23_11715	COG1216	Glycosyl transferase, family 2
GXM23_11720	COG1216	Glycosyl transferase, family 2
GXM23_11760	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
GXM23_11765	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GXM23_11765	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GXM23_11770	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
GXM23_11780	COG0280	phosphate acetyltransferase
GXM23_11780	COG0281	malic enzyme
GXM23_11795	COG1472	Belongs to the glycosyl hydrolase 3 family
GXM23_11800	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
GXM23_11815	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GXM23_11825	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
GXM23_11830	COG1063	alcohol dehydrogenase
GXM23_11845	COG0714	Associated with various cellular activities
GXM23_11855	COG0193	aminoacyl-tRNA hydrolase activity
GXM23_11860	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GXM23_11875	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
GXM23_11895	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
GXM23_11910	COG0375	protein maturation
GXM23_11930	COG3525	Glycosyl hydrolase, family 20, catalytic domain
GXM23_11935	COG0778	Nitroreductase
GXM23_11940	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GXM23_11960	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GXM23_11970	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
GXM23_11970	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
GXM23_11990	COG3525	Glycosyl hydrolase, family 20, catalytic domain
GXM23_11995	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
GXM23_12000	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
GXM23_12060	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GXM23_12065	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GXM23_12080	COG0318	PFAM AMP-dependent synthetase and ligase
GXM23_12105	COG0339	signal peptide processing
GXM23_12115	COG0018	arginyl-trna synthetase
GXM23_12160	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
GXM23_12165	COG0653	protein targeting
GXM23_12180	COG0494	nUDIX hydrolase