locus-tag	class	description
HZ994_00005	COG3119	arylsulfatase activity
HZ994_00015	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HZ994_00030	COG3738	Protein conserved in bacteria
HZ994_00035	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HZ994_00040	COG1216	Glycosyl transferase, family 2
HZ994_00065	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HZ994_00080	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HZ994_00095	COG0673	inositol 2-dehydrogenase activity
HZ994_00100	COG1324	tolerance protein
HZ994_00105	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HZ994_00115	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HZ994_00115	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HZ994_00125	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HZ994_00130	COG0351	phosphomethylpyrimidine kinase
HZ994_00145	COG0516	GMP reductase activity
HZ994_00145	COG0517	IMP dehydrogenase activity
HZ994_00150	COG0519	Catalyzes the synthesis of GMP from XMP
HZ994_00150	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HZ994_00160	COG0437	4 iron, 4 sulfur cluster binding
HZ994_00205	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HZ994_00210	COG1845	cytochrome c oxidase, subunit III
HZ994_00235	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HZ994_00255	COG2264	protein methyltransferase activity
HZ994_00260	COG1253	flavin adenine dinucleotide binding
HZ994_00290	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HZ994_00325	COG1702	phosphate starvation-inducible protein PhoH
HZ994_00335	COG4953	penicillin-binding protein 1C
HZ994_00355	COG0101	tRNA pseudouridine synthase activity
HZ994_00365	COG3738	Protein conserved in bacteria
HZ994_00375	COG0513	Belongs to the DEAD box helicase family
HZ994_00380	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HZ994_00385	COG3938	Belongs to the proline racemase family
HZ994_00390	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HZ994_00405	COG1160	GTP binding
HZ994_00445	COG0517	IMP dehydrogenase activity
HZ994_00515	COG0189	ligase activity
HZ994_00515	COG4067	protein conserved in archaea
HZ994_00525	COG0189	ligase activity
HZ994_00545	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HZ994_00550	COG0811	peptide transport
HZ994_00570	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HZ994_00575	COG0745	RESPONSE REGULATOR receiver
HZ994_00580	COG5002	protein histidine kinase activity
HZ994_00585	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HZ994_00605	COG0012	GTP binding
HZ994_00620	COG0432	Pfam Uncharacterised protein family UPF0047
HZ994_00635	COG3408	Glycogen debranching enzyme
HZ994_00635	COG3119	arylsulfatase activity
HZ994_00670	COG3046	protein related to deoxyribodipyrimidine photolyase
HZ994_00680	COG4221	oxidoreductase activity
HZ994_00685	COG0488	(ABC) transporter
HZ994_00695	COG1869	D-ribose catabolic process
HZ994_00700	COG1082	Xylose isomerase domain protein TIM barrel
HZ994_00705	COG0667	Aldo Keto reductase
HZ994_00715	COG1063	alcohol dehydrogenase
HZ994_00800	COG3547	Transposase (IS116 IS110 IS902 family)
HZ994_00855	COG0438	transferase activity, transferring glycosyl groups
HZ994_00860	COG0561	phosphatase activity
HZ994_00880	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HZ994_00890	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HZ994_00900	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HZ994_00930	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
HZ994_00955	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
HZ994_00960	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
HZ994_00965	COG0527	aspartate kinase activity
HZ994_00975	COG4654	Cytochrome c, class I
HZ994_01010	COG0084	hydrolase, TatD family'
HZ994_01040	COG2770	Histidine kinase
HZ994_01040	COG2208	phosphoserine phosphatase activity
HZ994_01045	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HZ994_01050	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HZ994_01055	COG0288	reversible hydration of carbon dioxide
HZ994_01065	COG3386	PFAM SMP-30 Gluconolaconase
HZ994_01110	COG3250	beta-galactosidase activity
HZ994_01130	COG4806	L-rhamnose isomerase
HZ994_01150	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HZ994_01155	COG0736	holo-[acyl-carrier-protein] synthase activity
HZ994_01160	COG0113	porphobilinogen synthase activity
HZ994_01180	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HZ994_01195	COG1538	Outer membrane efflux protein
HZ994_01205	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
HZ994_01215	COG4628	conserved protein (DUF2132)
HZ994_01235	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HZ994_01245	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
HZ994_01260	COG1104	cysteine desulfurase activity
HZ994_01290	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HZ994_01295	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HZ994_01295	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
HZ994_01305	COG1519	Transferase
HZ994_01310	COG0742	ribosomal rna small subunit methyltransferase
HZ994_01320	COG0631	protein serine/threonine phosphatase activity
HZ994_01325	COG0174	glutamine synthetase
HZ994_01330	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HZ994_01420	COG2205	protein histidine kinase activity
HZ994_01440	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HZ994_01450	COG1902	pentaerythritol trinitrate reductase activity
HZ994_01460	COG3119	arylsulfatase activity
HZ994_01470	COG3119	arylsulfatase activity
HZ994_01480	COG1595	DNA-templated transcription, initiation
HZ994_01485	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
HZ994_01515	COG0662	Cupin 2, conserved barrel domain protein
HZ994_01515	COG2207	Transcriptional regulator
HZ994_01520	COG3579	cysteine-type endopeptidase activity
HZ994_01550	COG0259	pyridoxamine-phosphate oxidase activity
HZ994_01560	COG1720	tRNA m6t6A37 methyltransferase activity
HZ994_01565	COG0138	bifunctional purine biosynthesis protein purh
HZ994_01585	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HZ994_01590	COG1722	exodeoxyribonuclease VII activity
HZ994_01600	COG2204	response regulator
HZ994_01605	COG3852	Histidine kinase
HZ994_01615	COG2192	nodulation
HZ994_01650	COG1643	Atp-dependent helicase
HZ994_01670	COG1028	Short-chain dehydrogenase reductase Sdr
HZ994_01670	COG3347	Dehydrogenase
HZ994_01675	COG1349	DNA-binding transcription factor activity
HZ994_01685	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HZ994_01695	COG1136	(ABC) transporter
HZ994_01700	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HZ994_01710	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HZ994_01715	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HZ994_01795	COG0268	Binds directly to 16S ribosomal RNA
HZ994_01805	COG1215	transferase activity, transferring glycosyl groups
HZ994_01815	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HZ994_01835	COG0702	epimerase
HZ994_01840	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HZ994_01845	COG1321	iron dependent repressor
HZ994_01865	COG0484	heat shock protein binding
HZ994_01870	COG0612	Peptidase, M16
HZ994_01895	COG1012	belongs to the aldehyde dehydrogenase family
HZ994_01900	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HZ994_01905	COG1793	dna ligase
HZ994_01905	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
HZ994_01920	COG0728	peptidoglycan biosynthetic process
HZ994_01940	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HZ994_01945	COG1070	Carbohydrate kinase
HZ994_01955	COG0513	Belongs to the DEAD box helicase family
HZ994_01965	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HZ994_01980	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
HZ994_02070	COG1064	alcohol dehydrogenase
HZ994_02075	COG3142	Participates in the control of copper homeostasis
HZ994_02085	COG3250	beta-galactosidase activity
HZ994_02125	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
HZ994_02135	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
HZ994_02175	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HZ994_02255	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HZ994_02295	COG0156	8-amino-7-oxononanoate synthase activity
HZ994_02315	COG1136	(ABC) transporter
HZ994_02380	COG1111	helicase
HZ994_02380	COG1205	dead DEAH box helicase
HZ994_02385	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HZ994_02420	COG1401	restriction endodeoxyribonuclease activity
HZ994_02515	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HZ994_02615	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HZ994_02625	COG0156	8-amino-7-oxononanoate synthase activity
HZ994_02630	COG1063	alcohol dehydrogenase
HZ994_02635	COG1609	Transcriptional regulator
HZ994_02650	COG0363	glucosamine-6-phosphate deaminase activity
HZ994_02670	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HZ994_02675	COG3123	guanosine phosphorylase activity
HZ994_02685	COG0545	Peptidyl-prolyl cis-trans isomerase
HZ994_02690	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
HZ994_02705	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HZ994_02710	COG3119	arylsulfatase activity
HZ994_02740	COG0316	Belongs to the HesB IscA family
HZ994_02745	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HZ994_02750	COG1131	(ABC) transporter
HZ994_02780	COG0667	Aldo Keto reductase
HZ994_02795	COG0575	Belongs to the CDS family
HZ994_02800	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HZ994_02810	COG0586	Pfam SNARE associated Golgi protein
HZ994_02815	COG1199	ATP-dependent helicase activity
HZ994_02830	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HZ994_02835	COG1480	7TM receptor with intracellular HD hydrolase
HZ994_02850	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
HZ994_02895	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HZ994_02900	COG0423	glycine-tRNA ligase activity
HZ994_02915	COG0358	DNA primase activity
HZ994_02915	COG0305	Participates in initiation and elongation during chromosome replication
HZ994_02940	COG2226	methyltransferase
HZ994_02960	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HZ994_02990	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HZ994_03010	COG0443	Heat shock 70 kDa protein
HZ994_03020	COG1562	ergosterol biosynthetic process
HZ994_03030	COG0492	ferredoxin-NADP+ reductase activity
HZ994_03035	COG1215	transferase activity, transferring glycosyl groups
HZ994_03085	COG1127	ABC transporter
HZ994_03090	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HZ994_03095	COG4969	Belongs to the N-Me-Phe pilin family
HZ994_03110	COG0134	indole-3-glycerol-phosphate synthase activity
HZ994_03125	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HZ994_03125	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HZ994_03140	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HZ994_03140	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HZ994_03155	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HZ994_03160	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HZ994_03165	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HZ994_03170	COG1760	l-serine dehydratase
HZ994_03195	COG0788	formyltetrahydrofolate deformylase activity
HZ994_03205	COG0544	peptidyl-prolyl cis-trans isomerase activity
HZ994_03210	COG0740	serine-type endopeptidase activity
HZ994_03220	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HZ994_03230	COG0322	excinuclease ABC activity
HZ994_03315	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
HZ994_03320	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HZ994_03325	COG3273	potassium ion transport
HZ994_03325	COG0471	metal ion transport
HZ994_03330	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HZ994_03335	COG1070	Carbohydrate kinase
HZ994_03340	COG2121	Domain of unknown function (DUF374)
HZ994_03345	COG3422	double-strand break repair
HZ994_03350	COG3942	CHAP domain
HZ994_03350	COG1388	LysM domain
HZ994_03355	COG0737	Belongs to the 5'-nucleotidase family
HZ994_03380	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HZ994_03385	COG2815	serine threonine protein kinase
HZ994_03385	COG0515	serine threonine protein kinase
HZ994_03390	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HZ994_03440	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HZ994_03445	COG0861	Integral membrane protein TerC family
HZ994_03460	COG1686	Belongs to the peptidase S11 family
HZ994_03465	COG0205	6-phosphofructokinase activity
HZ994_03470	COG0542	response to heat
HZ994_03480	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HZ994_03495	COG1649	PFAM Uncharacterised BCR, COG1649
HZ994_03515	COG0583	DNA-binding transcription factor activity
HZ994_03520	COG1116	anion transmembrane transporter activity
HZ994_03520	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HZ994_03540	COG0673	inositol 2-dehydrogenase activity
HZ994_03555	COG3273	potassium ion transport
HZ994_03555	COG0471	metal ion transport
HZ994_03560	COG3273	potassium ion transport
HZ994_03560	COG0471	metal ion transport
HZ994_03625	COG4585	Histidine kinase
HZ994_03630	COG2197	response regulator
HZ994_03640	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HZ994_03665	COG0848	biopolymer transport protein
HZ994_03670	COG0811	peptide transport
HZ994_03675	COG0811	peptide transport
HZ994_03705	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
HZ994_03710	COG1482	cell wall glycoprotein biosynthetic process
HZ994_03715	COG1475	DNA binding
HZ994_03725	COG0673	inositol 2-dehydrogenase activity
HZ994_03770	COG0799	negative regulation of ribosome biogenesis
HZ994_03815	COG0826	peptidase U32
HZ994_03850	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HZ994_03860	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HZ994_03885	COG2824	Alkylphosphonate utilization operon protein PhnA
HZ994_03890	COG0343	queuine tRNA-ribosyltransferase activity
HZ994_03900	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HZ994_03900	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HZ994_03910	COG0196	riboflavin kinase activity
HZ994_03915	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HZ994_03920	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HZ994_03925	COG0326	Molecular chaperone. Has ATPase activity
HZ994_03940	COG0792	nuclease activity
HZ994_03955	COG2211	Major facilitator Superfamily
HZ994_03975	COG3250	beta-galactosidase activity
HZ994_03995	COG1183	phosphatidylcholine synthase activity
HZ994_04010	COG1509	lysine 2,3-aminomutase activity
HZ994_04015	COG0657	acetylesterase activity
HZ994_04015	COG2755	lipolytic protein G-D-S-L family
HZ994_04030	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HZ994_04035	COG0124	histidyl-tRNA synthetase
HZ994_04050	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HZ994_04070	COG1254	Belongs to the acylphosphatase family
HZ994_04120	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HZ994_04130	COG1309	transcriptional regulator
HZ994_04140	COG0606	chelatase, subunit chli
HZ994_04185	COG0640	Transcriptional regulator
HZ994_04195	COG0446	pyridine nucleotide-disulphide oxidoreductase
HZ994_04220	COG2010	Cytochrome c
HZ994_04230	COG1368	sulfuric ester hydrolase activity
HZ994_04240	COG0745	RESPONSE REGULATOR receiver
HZ994_04245	COG2205	protein histidine kinase activity
HZ994_04250	COG1984	allophanate hydrolase subunit 2
HZ994_04255	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
HZ994_04265	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HZ994_04265	COG0475	glutathione-regulated potassium exporter activity
HZ994_04300	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HZ994_04315	COG0673	inositol 2-dehydrogenase activity
HZ994_04320	COG3119	arylsulfatase activity
HZ994_04330	COG0442	prolyl-tRNA aminoacylation
HZ994_04355	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HZ994_04365	COG1757	Na H antiporter
HZ994_04375	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HZ994_04380	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HZ994_04395	COG4974	Belongs to the 'phage' integrase family
HZ994_04400	COG1674	ftsk spoiiie
HZ994_04455	COG0232	Belongs to the dGTPase family. Type 2 subfamily
HZ994_04475	COG2308	Evidence 4 Homologs of previously reported genes of
HZ994_04485	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
HZ994_04490	COG3119	arylsulfatase activity
HZ994_04525	COG0321	lipoyl(octanoyl) transferase activity
HZ994_04540	COG1305	Transglutaminase-like
HZ994_04555	COG1940	carbohydrate kinase activity
HZ994_04560	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HZ994_04565	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HZ994_04585	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HZ994_04625	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HZ994_04630	COG0860	N-Acetylmuramoyl-L-alanine amidase
HZ994_04635	COG0497	DNA recombination
HZ994_04640	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HZ994_04650	COG2949	membrane
HZ994_04655	COG1597	lipid kinase activity
HZ994_04660	COG0424	maF-like protein
HZ994_04665	COG3386	PFAM SMP-30 Gluconolaconase
HZ994_04670	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HZ994_04680	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HZ994_04690	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HZ994_04710	COG1435	thymidine kinase activity
HZ994_04770	COG3041	Addiction module toxin RelE StbE family
HZ994_04825	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HZ994_04825	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HZ994_04835	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HZ994_04840	COG1301	dicarboxylic acid transport
HZ994_04855	COG2815	serine threonine protein kinase
HZ994_04855	COG0515	serine threonine protein kinase
HZ994_04860	COG0632	four-way junction helicase activity
HZ994_04865	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HZ994_04865	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
HZ994_04880	COG0646	methionine synthase
HZ994_04880	COG1410	methionine synthase
HZ994_04915	COG5564	TIM-barrel signal transduction protein
HZ994_04925	COG0318	PFAM AMP-dependent synthetase and ligase
HZ994_04940	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HZ994_04945	COG0335	large ribosomal subunit rRNA binding
HZ994_04955	COG1988	membrane-bound metal-dependent
HZ994_04960	COG0052	Belongs to the universal ribosomal protein uS2 family
HZ994_04965	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HZ994_04970	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HZ994_04985	COG2239	Acts as a magnesium transporter
HZ994_05000	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
HZ994_05005	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HZ994_05010	COG2226	methyltransferase
HZ994_05015	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HZ994_05020	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HZ994_05020	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HZ994_05025	COG1028	Short-chain dehydrogenase reductase Sdr
HZ994_05060	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
HZ994_05070	COG0534	Mate efflux family protein
HZ994_05090	COG1595	DNA-templated transcription, initiation
HZ994_05110	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HZ994_05115	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HZ994_05120	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HZ994_05125	COG1007	ATP synthesis coupled electron transport
HZ994_05130	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
HZ994_05135	COG0083	homoserine kinase activity
HZ994_05140	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HZ994_05145	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HZ994_05155	COG1115	amino acid carrier protein
HZ994_05165	COG1073	alpha beta
HZ994_05170	COG2084	Dehydrogenase
HZ994_05190	COG0205	6-phosphofructokinase activity
HZ994_05200	COG0494	nUDIX hydrolase
HZ994_05250	COG4591	ABC-type transport system involved in lipoprotein release permease component
HZ994_05260	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
HZ994_05280	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HZ994_05285	COG0154	amidase activity
HZ994_05295	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HZ994_05300	COG3265	gluconokinase activity
HZ994_05305	COG0444	Belongs to the ABC transporter superfamily
HZ994_05315	COG1160	GTP binding
HZ994_05325	COG0772	Belongs to the SEDS family
HZ994_05330	COG3119	arylsulfatase activity
HZ994_05365	COG0277	FAD linked oxidase domain protein
HZ994_05370	COG2322	membrane
HZ994_05390	COG0714	Associated with various cellular activities
HZ994_05400	COG1131	(ABC) transporter
HZ994_05415	COG0811	peptide transport
HZ994_05445	COG3119	arylsulfatase activity
HZ994_05455	COG0628	permease
HZ994_05460	COG1612	heme a metabolic process
HZ994_05470	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HZ994_05535	COG0823	Involved in the tonB-independent uptake of proteins
HZ994_05540	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HZ994_05545	COG0724	RNA recognition motif
HZ994_05550	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
HZ994_05585	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HZ994_05610	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HZ994_05635	COG0137	argininosuccinate synthase activity
HZ994_05640	COG3739	integral membrane protein
HZ994_05660	COG3842	ATPase activity
HZ994_05665	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
HZ994_05680	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HZ994_05685	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
HZ994_05690	COG1363	Peptidase, m42
HZ994_05700	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HZ994_05705	COG1333	cytochrome c biogenesis protein
HZ994_05715	COG0688	phosphatidylethanolamine metabolic process
HZ994_05730	COG1609	Transcriptional regulator
HZ994_05740	COG0673	inositol 2-dehydrogenase activity
HZ994_05755	COG0126	phosphoglycerate kinase activity
HZ994_05760	COG0149	triose-phosphate isomerase activity
HZ994_05790	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HZ994_05800	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
HZ994_05815	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HZ994_05820	COG4608	Belongs to the ABC transporter superfamily
HZ994_05825	COG0444	Belongs to the ABC transporter superfamily
HZ994_05835	COG4239	(ABC) transporter, permease
HZ994_05855	COG1132	(ABC) transporter
HZ994_05860	COG0546	phosphoglycolate phosphatase activity
HZ994_05865	COG1858	cytochrome C peroxidase
HZ994_05885	COG1863	multisubunit Na H antiporter MnhE subunit
HZ994_05890	COG0651	ATP synthesis coupled electron transport
HZ994_05895	COG1006	Multisubunit Na H antiporter MnhC subunit
HZ994_05900	COG2111	Na H antiporter
HZ994_05905	COG2111	Na H antiporter
HZ994_05905	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HZ994_05915	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HZ994_05920	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HZ994_05935	COG0275	rRNA processing
HZ994_05945	COG0768	penicillin binding
HZ994_05950	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HZ994_05955	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HZ994_05965	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HZ994_05970	COG1388	LysM domain
HZ994_05970	COG5632	N-Acetylmuramoyl-L-alanine amidase
HZ994_05970	COG3409	Peptidoglycan-binding domain 1 protein
HZ994_05985	COG3119	arylsulfatase activity
HZ994_05995	COG1013	pyruvate-flavodoxin oxidoreductase activity
HZ994_06000	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HZ994_06000	COG0674	pyruvate-flavodoxin oxidoreductase activity
HZ994_06005	COG3119	arylsulfatase activity
HZ994_06015	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HZ994_06025	COG0436	Aminotransferase
HZ994_06030	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HZ994_06040	COG0123	including yeast histone deacetylase and acetoin utilization protein
HZ994_06050	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HZ994_06055	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HZ994_06085	COG0159	tryptophan synthase activity
HZ994_06090	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HZ994_06095	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HZ994_06110	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
HZ994_06120	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HZ994_06130	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HZ994_06160	COG0482	sulfurtransferase activity
HZ994_06175	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
HZ994_06200	COG0628	permease
HZ994_06205	COG1943	Transposase
HZ994_06215	COG1904	glucuronate isomerase
HZ994_06220	COG2706	6-phosphogluconolactonase activity
HZ994_06225	COG1970	mechanosensitive ion channel activity
HZ994_06230	COG1522	sequence-specific DNA binding
HZ994_06275	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HZ994_06280	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HZ994_06285	COG1121	(ABC) transporter
HZ994_06290	COG0803	Belongs to the bacterial solute-binding protein 9 family
HZ994_06300	COG3119	arylsulfatase activity
HZ994_06310	COG0037	tRNA processing
HZ994_06315	COG1054	Belongs to the UPF0176 family
HZ994_06335	COG0175	sulfate reduction
HZ994_06340	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HZ994_06345	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HZ994_06350	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HZ994_06360	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HZ994_06365	COG1477	protein flavinylation
HZ994_06375	COG1053	succinate dehydrogenase
HZ994_06390	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HZ994_06400	COG1331	Highly conserved protein containing a thioredoxin domain
HZ994_06405	COG2309	aminopeptidase activity
HZ994_06415	COG0686	Belongs to the AlaDH PNT family
HZ994_06420	COG2022	thiamine diphosphate biosynthetic process
HZ994_06440	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HZ994_06465	COG1215	transferase activity, transferring glycosyl groups
HZ994_06505	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HZ994_06510	COG0489	protein tyrosine kinase activity
HZ994_06520	COG0438	transferase activity, transferring glycosyl groups
HZ994_06535	COG1696	Membrane protein involved in D-alanine export
HZ994_06545	COG0438	transferase activity, transferring glycosyl groups
HZ994_06555	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HZ994_06560	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HZ994_06565	COG1045	serine acetyltransferase
HZ994_06655	COG2197	response regulator
HZ994_06660	COG4585	Histidine kinase
HZ994_06680	COG3119	arylsulfatase activity
HZ994_06695	COG3119	arylsulfatase activity
HZ994_06695	COG3408	Glycogen debranching enzyme
HZ994_06710	COG3119	arylsulfatase activity
HZ994_06780	COG3250	beta-galactosidase activity
HZ994_06800	COG0714	Associated with various cellular activities
HZ994_06835	COG3119	arylsulfatase activity
HZ994_06840	COG3119	arylsulfatase activity
HZ994_06845	COG3119	arylsulfatase activity
HZ994_06960	COG3119	arylsulfatase activity
HZ994_06965	COG3119	arylsulfatase activity
HZ994_06975	COG4585	Histidine kinase
HZ994_06990	COG3119	arylsulfatase activity
HZ994_07015	COG3119	arylsulfatase activity
HZ994_07045	COG0277	FAD linked oxidase domain protein
HZ994_07065	COG0720	synthase
HZ994_07070	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HZ994_07075	COG0307	riboflavin synthase, alpha
HZ994_07080	COG1250	3-hydroxyacyl-CoA dehydrogenase
HZ994_07080	COG1024	Enoyl-CoA hydratase
HZ994_07085	COG0183	Belongs to the thiolase family
HZ994_07090	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
HZ994_07095	COG1752	Esterase of the alpha-beta hydrolase superfamily
HZ994_07125	COG0004	ammonium transporteR
HZ994_07130	COG1686	Belongs to the peptidase S11 family
HZ994_07135	COG0156	8-amino-7-oxononanoate synthase activity
HZ994_07140	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HZ994_07180	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HZ994_07200	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
HZ994_07270	COG1741	Belongs to the pirin family
HZ994_07275	COG0583	DNA-binding transcription factor activity
HZ994_07285	COG0352	thiamine-phosphate diphosphorylase activity
HZ994_07290	COG0439	Biotin carboxylase
HZ994_07295	COG0511	ligase activity, forming carbon-carbon bonds
HZ994_07315	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HZ994_07325	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
HZ994_07330	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
HZ994_07335	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HZ994_07345	COG0529	Catalyzes the synthesis of activated sulfate
HZ994_07355	COG0175	sulfate reduction
HZ994_07395	COG0463	Glycosyl transferase, family 2
HZ994_07435	COG4106	trans-aconitate 2-methyltransferase activity
HZ994_07445	COG0438	transferase activity, transferring glycosyl groups
HZ994_07480	COG0438	transferase activity, transferring glycosyl groups
HZ994_07485	COG1215	transferase activity, transferring glycosyl groups
HZ994_07520	COG0463	Glycosyl transferase, family 2
HZ994_07540	COG1215	transferase activity, transferring glycosyl groups
HZ994_07550	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HZ994_07580	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HZ994_07585	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
HZ994_07610	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HZ994_07620	COG1570	exodeoxyribonuclease VII activity
HZ994_07630	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HZ994_07635	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HZ994_07660	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HZ994_07670	COG0612	Peptidase, M16
HZ994_07680	COG3119	arylsulfatase activity
HZ994_07720	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HZ994_07735	COG3119	arylsulfatase activity
HZ994_07740	COG1640	4-alpha-glucanotransferase
HZ994_07755	COG1575	Belongs to the MenA family. Type 1 subfamily
HZ994_07760	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
HZ994_07765	COG2217	Heavy metal translocating P-type atpase
HZ994_07775	COG1309	transcriptional regulator
HZ994_07785	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HZ994_07790	COG0284	orotidine-5'-phosphate decarboxylase activity
HZ994_07805	COG0481	GTPase activity
HZ994_07820	COG0024	Methionine aminopeptidase
HZ994_07825	COG0563	adenylate kinase activity
HZ994_07835	COG0200	Binds to the 23S rRNA
HZ994_07840	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HZ994_07845	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HZ994_07850	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HZ994_07855	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HZ994_07860	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HZ994_07865	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HZ994_07870	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HZ994_07875	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HZ994_07880	COG0255	Belongs to the universal ribosomal protein uL29 family
HZ994_07885	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HZ994_07890	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HZ994_07895	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HZ994_07905	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HZ994_07910	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HZ994_07915	COG0089	rRNA binding
HZ994_07920	COG0088	Forms part of the polypeptide exit tunnel
HZ994_07925	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HZ994_07930	COG0051	transcription antitermination factor activity, RNA binding
HZ994_07935	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HZ994_07940	COG0049	tRNA binding
HZ994_07945	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HZ994_07980	COG0863	Belongs to the N(4) N(6)-methyltransferase family
HZ994_07995	COG2183	response to ionizing radiation
HZ994_08010	COG0571	ribonuclease III activity
HZ994_08090	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HZ994_08110	COG3119	arylsulfatase activity
HZ994_08140	COG1194	a g-specific adenine glycosylase
HZ994_08145	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HZ994_08205	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HZ994_08220	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HZ994_08225	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HZ994_08230	COG1185	polyribonucleotide nucleotidyltransferase activity
HZ994_08235	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HZ994_08260	COG1177	transmembrane transport
HZ994_08265	COG1176	ABC-type spermidine putrescine transport system, permease component I
HZ994_08270	COG3842	ATPase activity
HZ994_08280	COG3940	Belongs to the glycosyl hydrolase 43 family
HZ994_08345	COG2815	serine threonine protein kinase
HZ994_08345	COG0515	serine threonine protein kinase
HZ994_08380	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HZ994_08385	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HZ994_08420	COG0515	serine threonine protein kinase
HZ994_08420	COG2815	serine threonine protein kinase
HZ994_08440	COG2207	Transcriptional regulator
HZ994_08440	COG3708	Transcriptional regulator
HZ994_08450	COG1404	Belongs to the peptidase S8 family
HZ994_08455	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HZ994_08470	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HZ994_08475	COG2818	Glycosylase
HZ994_08495	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HZ994_08515	COG1129	ABC transporter
HZ994_08530	COG1172	Belongs to the binding-protein-dependent transport system permease family
HZ994_08595	COG0189	ligase activity
HZ994_08595	COG0569	domain protein
HZ994_08640	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HZ994_08650	COG2197	response regulator
HZ994_08680	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
HZ994_08690	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HZ994_08695	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HZ994_08700	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HZ994_08705	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HZ994_08715	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HZ994_08720	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HZ994_08725	COG0356	it plays a direct role in the translocation of protons across the membrane
HZ994_08745	COG4956	integral membrane protein (PIN domain superfamily)
HZ994_08780	COG3119	arylsulfatase activity
HZ994_08790	COG3119	arylsulfatase activity
HZ994_08795	COG4213	ABC transporter substrate-binding protein
HZ994_08800	COG1129	ABC transporter
HZ994_08805	COG4214	carbohydrate transport
HZ994_08850	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HZ994_08855	COG0564	pseudouridine synthase activity
HZ994_08865	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HZ994_08880	COG0778	Nitroreductase
HZ994_08900	COG0573	inorganic phosphate transmembrane transporter activity
HZ994_08905	COG0581	inorganic phosphate transmembrane transporter activity
HZ994_08910	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HZ994_08915	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HZ994_08920	COG0704	Plays a role in the regulation of phosphate uptake
HZ994_08935	COG2890	protein-(glutamine-N5) methyltransferase activity
HZ994_08940	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HZ994_08955	COG0601	transmembrane transport
HZ994_08960	COG4166	transmembrane transport
HZ994_08970	COG5002	protein histidine kinase activity
HZ994_08990	COG0848	biopolymer transport protein
HZ994_08995	COG0848	biopolymer transport protein
HZ994_09000	COG0811	peptide transport
HZ994_09025	COG0017	Asparaginyl-tRNA synthetase
HZ994_09030	COG0071	Belongs to the small heat shock protein (HSP20) family
HZ994_09035	COG0811	peptide transport
HZ994_09040	COG0848	biopolymer transport protein
HZ994_09050	COG2239	Acts as a magnesium transporter
HZ994_09060	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
HZ994_09075	COG0367	asparagine synthase
HZ994_09080	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HZ994_09100	COG5002	protein histidine kinase activity
HZ994_09105	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HZ994_09120	COG1848	Toxic component of a toxin-antitoxin (TA) module. An RNase
HZ994_09190	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HZ994_09215	COG2826	transposase and inactivated derivatives, IS30 family
HZ994_09240	COG3547	Transposase (IS116 IS110 IS902 family)
HZ994_09300	COG3547	Transposase (IS116 IS110 IS902 family)
HZ994_09325	COG3547	Transposase (IS116 IS110 IS902 family)
HZ994_09600	COG0028	Belongs to the TPP enzyme family
HZ994_09605	COG1994	Peptidase M50
HZ994_09630	COG0537	adenosine 5'-monophosphoramidase activity
HZ994_09660	COG5433	transposase activity
HZ994_09670	COG0429	hydrolase of the alpha beta-hydrolase fold
HZ994_09685	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HZ994_09690	COG0726	polysaccharide deacetylase
HZ994_09695	COG2165	general secretion pathway protein
HZ994_09705	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HZ994_09715	COG0735	belongs to the Fur family
HZ994_09720	COG0396	ATPase activity
HZ994_09725	COG0719	Fe-S assembly protein
HZ994_09750	COG1573	uracil-dna glycosylase
HZ994_09755	COG2115	Belongs to the xylose isomerase family
HZ994_09760	COG2382	esterase
HZ994_09765	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HZ994_09785	COG3119	arylsulfatase activity
HZ994_09840	COG3119	arylsulfatase activity
HZ994_09840	COG3408	Glycogen debranching enzyme
HZ994_09860	COG0525	valine-tRNA ligase activity
HZ994_09920	COG2205	protein histidine kinase activity
HZ994_09925	COG1858	cytochrome C peroxidase
HZ994_09935	COG2382	esterase
HZ994_09940	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HZ994_09945	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
HZ994_09970	COG1459	type II secretion system
HZ994_09985	COG1598	PFAM Uncharacterised protein family UPF0150
HZ994_09990	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HZ994_10005	COG5002	protein histidine kinase activity
HZ994_10010	COG0745	RESPONSE REGULATOR receiver
HZ994_10015	COG1595	DNA-templated transcription, initiation
HZ994_10030	COG0285	dihydrofolate synthase activity
HZ994_10035	COG0552	protein localization to endoplasmic reticulum
HZ994_10055	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
HZ994_10065	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HZ994_10070	COG0359	binds to the 23S rRNA
HZ994_10080	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
HZ994_10090	COG0004	ammonium transporteR
HZ994_10100	COG1070	Carbohydrate kinase
HZ994_10105	COG1028	Short-chain dehydrogenase reductase Sdr
HZ994_10110	COG2062	phosphohistidine phosphatase, SixA
HZ994_10115	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HZ994_10135	COG0647	UMP catabolic process
HZ994_10140	COG3119	arylsulfatase activity
HZ994_10150	COG0612	Peptidase, M16
HZ994_10165	COG0105	UTP biosynthetic process
HZ994_10180	COG0009	L-threonylcarbamoyladenylate synthase
HZ994_10200	COG3119	arylsulfatase activity
HZ994_10245	COG3008	intermembrane lipid transfer
HZ994_10245	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HZ994_10250	COG2995	paraquat-inducible protein a
HZ994_10260	COG0179	Fumarylacetoacetate (FAA) hydrolase
HZ994_10275	COG0109	protoheme IX farnesyltransferase activity
HZ994_10280	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HZ994_10295	COG0798	PFAM Bile acid sodium symporter
HZ994_10300	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HZ994_10325	COG3119	arylsulfatase activity
HZ994_10330	COG3119	arylsulfatase activity
HZ994_10345	COG1053	succinate dehydrogenase
HZ994_10350	COG4608	Belongs to the ABC transporter superfamily
HZ994_10390	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HZ994_10420	COG2315	Protein conserved in bacteria
HZ994_10490	COG0270	DNA (cytosine-5-)-methyltransferase activity
HZ994_10495	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HZ994_10495	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HZ994_10530	COG0280	phosphate acetyltransferase
HZ994_10545	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HZ994_10550	COG2827	Endonuclease containing a URI domain
HZ994_10565	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HZ994_10580	COG3119	arylsulfatase activity
HZ994_10600	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HZ994_10610	COG3034	peptidoglycan biosynthetic process
HZ994_10615	COG3698	Phosphodiester glycosidase
HZ994_10640	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HZ994_10650	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HZ994_10665	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HZ994_10670	COG0248	Ppx GppA phosphatase
HZ994_10675	COG2326	polyphosphate kinase activity
HZ994_10690	COG1959	2 iron, 2 sulfur cluster binding
HZ994_10710	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HZ994_10740	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HZ994_10760	COG3278	Belongs to the heme-copper respiratory oxidase family
HZ994_10770	COG2010	Cytochrome c
HZ994_10785	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HZ994_10790	COG0509	glycine decarboxylation via glycine cleavage system
HZ994_10795	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HZ994_10800	COG0659	secondary active sulfate transmembrane transporter activity
HZ994_10805	COG0589	response to stress
HZ994_10815	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HZ994_10820	COG1119	ATPase activity
HZ994_10825	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HZ994_10825	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HZ994_10830	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HZ994_10830	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HZ994_10840	COG0508	dehydrogenase complex catalyzes the overall conversion of
HZ994_10850	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HZ994_10860	COG2205	protein histidine kinase activity
HZ994_10865	COG0745	RESPONSE REGULATOR receiver
HZ994_10880	COG0336	Belongs to the RNA methyltransferase TrmD family
HZ994_10905	COG0114	fumarate hydratase activity
HZ994_10910	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HZ994_10915	COG1322	Protein conserved in bacteria
HZ994_10925	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HZ994_10930	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HZ994_10955	COG0386	Belongs to the glutathione peroxidase family
HZ994_10965	COG0372	Belongs to the citrate synthase family
HZ994_10975	COG2261	transglycosylase associated protein
HZ994_10985	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HZ994_11050	COG1217	gtp-binding protein TYPA
HZ994_11055	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
HZ994_11065	COG1917	Cupin 2, conserved barrel domain protein
HZ994_11065	COG2207	Transcriptional regulator
HZ994_11075	COG1187	pseudouridine synthase activity
HZ994_11105	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
HZ994_11110	COG0295	cytidine deaminase activity
HZ994_11115	COG0445	tRNA wobble uridine modification
HZ994_11130	COG1187	pseudouridine synthase activity
HZ994_11140	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HZ994_11185	COG1704	LemA family
HZ994_11230	COG3547	Transposase (IS116 IS110 IS902 family)
HZ994_11265	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HZ994_11290	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HZ994_11375	COG2201	protein-glutamate methylesterase activity
HZ994_11390	COG3459	Glycosyltransferase 36 associated
HZ994_11420	COG2197	response regulator
HZ994_11430	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
HZ994_11435	COG3119	arylsulfatase activity
HZ994_11600	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HZ994_11715	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HZ994_11750	COG3408	Glycogen debranching enzyme
HZ994_11765	COG2197	response regulator
HZ994_11775	COG2010	Cytochrome c
HZ994_11780	COG4585	Histidine kinase
HZ994_11795	COG3119	arylsulfatase activity
HZ994_11830	COG1132	(ABC) transporter
HZ994_11895	COG0084	hydrolase, TatD family'
HZ994_11900	COG0653	protein targeting
HZ994_11930	COG0167	dihydroorotate dehydrogenase activity
HZ994_11935	COG0191	fructose-bisphosphate aldolase activity
HZ994_11950	COG1074	ATP-dependent DNA helicase activity
HZ994_11955	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HZ994_11990	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HZ994_11995	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HZ994_12000	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HZ994_12020	COG0628	permease
HZ994_12030	COG0515	serine threonine protein kinase
HZ994_12050	COG0217	transcriptional regulatory protein
HZ994_12055	COG0592	DNA-directed DNA polymerase activity
HZ994_12065	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HZ994_12070	COG0022	dehydrogenase e1 component
HZ994_12070	COG0508	dehydrogenase complex catalyzes the overall conversion of
HZ994_12075	COG3119	arylsulfatase activity
HZ994_12080	COG3119	arylsulfatase activity
HZ994_12085	COG3119	arylsulfatase activity
HZ994_12100	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HZ994_12105	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HZ994_12110	COG1051	belongs to the nudix hydrolase family
HZ994_12125	COG0045	succinate-CoA ligase (ADP-forming) activity
HZ994_12130	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HZ994_12160	COG1131	(ABC) transporter
HZ994_12175	COG0242	peptide deformylase activity
HZ994_12185	COG0545	Peptidyl-prolyl cis-trans isomerase
HZ994_12210	COG1137	ATPase activity
HZ994_12225	COG3436	PFAM IS66 Orf2 family protein
HZ994_12250	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HZ994_12260	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HZ994_12265	COG0385	Bile acid
HZ994_12270	COG1252	NADH dehydrogenase
HZ994_12275	COG3119	arylsulfatase activity
HZ994_12300	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HZ994_12315	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
HZ994_12325	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HZ994_12335	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HZ994_12365	COG1940	carbohydrate kinase activity
HZ994_12375	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HZ994_12380	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HZ994_12390	COG0768	penicillin binding
HZ994_12400	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HZ994_12405	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HZ994_12440	COG0811	peptide transport
HZ994_12480	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HZ994_12485	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HZ994_12490	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HZ994_12500	COG0546	phosphoglycolate phosphatase activity
HZ994_12510	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HZ994_12525	COG1040	competence protein
HZ994_12545	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HZ994_12550	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HZ994_12555	COG1028	Short-chain dehydrogenase reductase Sdr
HZ994_12575	COG0590	tRNA wobble adenosine to inosine editing
HZ994_12635	COG1090	epimerase
HZ994_12650	COG1940	carbohydrate kinase activity
HZ994_12660	COG0848	biopolymer transport protein
HZ994_12665	COG0811	peptide transport
HZ994_12675	COG0596	Alpha beta hydrolase
HZ994_12700	COG0489	protein tyrosine kinase activity
HZ994_12715	COG1187	pseudouridine synthase activity
HZ994_12720	COG3118	belongs to the thioredoxin family
HZ994_12745	COG3119	arylsulfatase activity
HZ994_12745	COG3408	Glycogen debranching enzyme
HZ994_12750	COG0105	UTP biosynthetic process
HZ994_12760	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HZ994_12760	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HZ994_12765	COG2311	Membrane
HZ994_12770	COG3119	arylsulfatase activity
HZ994_12810	COG0582	viral genome integration into host DNA
HZ994_12815	COG2207	Transcriptional regulator
HZ994_12840	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HZ994_12840	COG3153	acetyltransferase
HZ994_12875	COG1131	(ABC) transporter
HZ994_12885	COG0508	dehydrogenase complex catalyzes the overall conversion of
HZ994_12890	COG1132	(ABC) transporter
HZ994_12900	COG1132	(ABC) transporter
HZ994_12910	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HZ994_12915	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HZ994_12930	COG1136	(ABC) transporter
HZ994_12960	COG0194	GDP metabolic process
HZ994_12980	COG3118	belongs to the thioredoxin family
HZ994_12985	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HZ994_12990	COG2197	response regulator
HZ994_13000	COG1692	metallophosphoesterase
HZ994_13010	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HZ994_13030	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HZ994_13035	COG0081	regulation of translation
HZ994_13040	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HZ994_13045	COG0222	ribosome binding
HZ994_13050	COG0085	RNA polymerase activity
HZ994_13055	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HZ994_13065	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HZ994_13070	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HZ994_13070	COG0574	Belongs to the PEP-utilizing enzyme family
HZ994_13075	COG0006	proline dipeptidase activity
HZ994_13085	COG0135	phosphoribosylanthranilate isomerase activity
HZ994_13090	COG0084	hydrolase, TatD family'
HZ994_13095	COG1388	LysM domain
HZ994_13095	COG1705	Flagellar rod assembly protein muramidase FlgJ
HZ994_13135	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HZ994_13150	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HZ994_13160	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HZ994_13165	COG2321	neutral zinc metallopeptidase
HZ994_13170	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HZ994_13170	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HZ994_13175	COG0681	Belongs to the peptidase S26 family
HZ994_13185	COG2723	6-phospho-beta-galactosidase activity
HZ994_13190	COG3119	arylsulfatase activity
HZ994_13205	COG0811	peptide transport
HZ994_13210	COG0848	biopolymer transport protein
HZ994_13260	COG2815	serine threonine protein kinase
HZ994_13260	COG0515	serine threonine protein kinase
HZ994_13270	COG3119	arylsulfatase activity
HZ994_13285	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HZ994_13290	COG0676	glucose-6-phosphate 1-epimerase activity
HZ994_13305	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HZ994_13330	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HZ994_13340	COG0860	N-Acetylmuramoyl-L-alanine amidase
HZ994_13340	COG1388	LysM domain
HZ994_13345	COG0347	Belongs to the P(II) protein family
HZ994_13380	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HZ994_13410	COG1730	sister chromatid segregation
HZ994_13415	COG3119	arylsulfatase activity
HZ994_13435	COG2207	Transcriptional regulator
HZ994_13485	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HZ994_13510	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HZ994_13520	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HZ994_13525	COG3119	arylsulfatase activity
HZ994_13545	COG4221	oxidoreductase activity
HZ994_13570	COG0129	dihydroxy-acid dehydratase activity
HZ994_13580	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HZ994_13585	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HZ994_13590	COG0416	fatty acid biosynthetic process
HZ994_13595	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HZ994_13610	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HZ994_13620	COG3119	arylsulfatase activity
HZ994_13630	COG3119	arylsulfatase activity
HZ994_13635	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HZ994_13640	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HZ994_13725	COG0783	Belongs to the Dps family
HZ994_13745	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HZ994_13755	COG4864	UPF0365 protein
HZ994_13770	COG3485	protocatechuate 3,4-dioxygenase
HZ994_13775	COG0514	ATP-dependent DNA helicase (RecQ)
HZ994_13785	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HZ994_13800	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HZ994_13820	COG0542	response to heat
HZ994_13825	COG3869	Catalyzes the specific phosphorylation of arginine residues in
HZ994_13845	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HZ994_13860	COG0594	ribonuclease P activity
HZ994_13875	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HZ994_13895	COG0205	6-phosphofructokinase activity
HZ994_13925	COG0415	Belongs to the DNA photolyase family
HZ994_13935	COG0202	RNA polymerase activity
HZ994_13940	COG0203	ribosomal protein L17
HZ994_13965	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HZ994_13975	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HZ994_13990	COG0495	leucyl-tRNA aminoacylation
HZ994_14025	COG0366	Alpha amylase catalytic
HZ994_14050	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
HZ994_14060	COG0732	type I restriction modification DNA specificity domain
HZ994_14080	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
HZ994_14085	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HZ994_14090	COG1595	DNA-templated transcription, initiation
HZ994_14125	COG0776	regulation of translation
HZ994_14130	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HZ994_14135	COG1663	tetraacyldisaccharide 4'-kinase activity
HZ994_14140	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HZ994_14145	COG0714	Associated with various cellular activities
HZ994_14155	COG1640	4-alpha-glucanotransferase
HZ994_14165	COG2165	general secretion pathway protein
HZ994_14170	COG1459	type II secretion system
HZ994_14175	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HZ994_14180	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HZ994_14190	COG0228	four-way junction DNA binding
HZ994_14200	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HZ994_14210	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HZ994_14210	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HZ994_14220	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HZ994_14230	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HZ994_14250	COG3119	arylsulfatase activity
HZ994_14265	COG0701	Predicted permease
HZ994_14275	COG0142	geranyltranstransferase activity
HZ994_14300	COG2154	pterin-4-alpha-carbinolamine dehydratase
HZ994_14320	COG3481	metal-dependent phosphohydrolase, HD sub domain
HZ994_14325	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
HZ994_14335	COG0471	metal ion transport
HZ994_14340	COG1132	(ABC) transporter
HZ994_14355	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HZ994_14370	COG3119	arylsulfatase activity
HZ994_14375	COG0803	Belongs to the bacterial solute-binding protein 9 family
HZ994_14380	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HZ994_14395	COG0805	protein transport
HZ994_14415	COG2805	Type II/IV secretion system protein
HZ994_14445	COG3547	Transposase (IS116 IS110 IS902 family)
HZ994_14525	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HZ994_14540	COG0545	Peptidyl-prolyl cis-trans isomerase
HZ994_14550	COG2373	Large extracellular alpha-helical protein
HZ994_14595	COG3335	DDE superfamily endonuclease
HZ994_14610	COG3228	Belongs to the MtfA family
HZ994_14615	COG0515	serine threonine protein kinase
HZ994_14640	COG1073	alpha beta
HZ994_14645	COG1643	Atp-dependent helicase
HZ994_14650	COG3119	arylsulfatase activity
HZ994_14685	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HZ994_14690	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HZ994_14720	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
HZ994_14725	COG0508	dehydrogenase complex catalyzes the overall conversion of
HZ994_14735	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HZ994_14745	COG0039	L-malate dehydrogenase activity
HZ994_14750	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HZ994_14755	COG0215	cysteine-tRNA ligase activity
HZ994_14775	COG1181	Belongs to the D-alanine--D-alanine ligase family
HZ994_14790	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HZ994_14815	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HZ994_14825	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
HZ994_14845	COG1132	(ABC) transporter
HZ994_14855	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HZ994_14860	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HZ994_14865	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HZ994_14870	COG0714	Associated with various cellular activities
HZ994_14890	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HZ994_14895	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
HZ994_14905	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HZ994_14905	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HZ994_14945	COG0179	Fumarylacetoacetate (FAA) hydrolase
HZ994_14970	COG3956	TIGRFAM MazG family protein
HZ994_14995	COG2197	response regulator
HZ994_15005	COG1333	cytochrome c biogenesis protein
HZ994_15005	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HZ994_15010	COG1333	cytochrome c biogenesis protein
HZ994_15020	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HZ994_15025	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HZ994_15035	COG0528	UMP kinase activity
HZ994_15040	COG0233	cytoplasmic translational termination
HZ994_15080	COG0708	Exodeoxyribonuclease III
HZ994_15085	COG1166	arginine decarboxylase activity
HZ994_15090	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HZ994_15095	COG0793	Belongs to the peptidase S41A family
HZ994_15110	COG0166	Belongs to the GPI family
HZ994_15145	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HZ994_15150	COG0471	metal ion transport
HZ994_15220	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HZ994_15285	COG0537	adenosine 5'-monophosphoramidase activity
HZ994_15330	COG2378	regulation of single-species biofilm formation
HZ994_15380	COG4581	dead DEAH box helicase
HZ994_15390	COG0023	Translation Initiation Factor
HZ994_15405	COG1605	Chorismate mutase
HZ994_15405	COG0077	Prephenate dehydratase
HZ994_15410	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HZ994_15415	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HZ994_15420	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HZ994_15425	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HZ994_15430	COG1469	GTP cyclohydrolase I activity
HZ994_15435	COG3119	arylsulfatase activity
HZ994_15440	COG0714	Associated with various cellular activities
HZ994_15470	COG0583	DNA-binding transcription factor activity
HZ994_15475	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
HZ994_15480	COG0277	FAD linked oxidase domain protein
HZ994_15510	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
HZ994_15515	COG1468	defense response to virus
HZ994_15515	COG1518	maintenance of DNA repeat elements
HZ994_15555	COG1253	flavin adenine dinucleotide binding
HZ994_15570	COG0218	Necessary for normal cell division and for the maintenance of normal septation
HZ994_15590	COG1607	acyl-coa hydrolase
HZ994_15595	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
HZ994_15605	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HZ994_15610	COG2814	Major facilitator Superfamily
HZ994_15620	COG1959	2 iron, 2 sulfur cluster binding
HZ994_15655	COG0107	imidazoleglycerol-phosphate synthase activity
HZ994_15660	COG3254	rhamnose metabolic process
HZ994_15665	COG3119	arylsulfatase activity
HZ994_15665	COG3408	Glycogen debranching enzyme
HZ994_15670	COG0825	malonyl-CoA metabolic process
HZ994_15685	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HZ994_15710	COG2963	transposase activity
HZ994_15725	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HZ994_15755	COG0066	3-isopropylmalate dehydratase activity
HZ994_15760	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HZ994_15770	COG3647	Membrane
HZ994_15790	COG0038	chloride channel
HZ994_15800	COG0534	Mate efflux family protein
HZ994_15810	COG1253	flavin adenine dinucleotide binding
HZ994_15820	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HZ994_15830	COG0745	RESPONSE REGULATOR receiver
HZ994_15835	COG5002	protein histidine kinase activity
HZ994_15850	COG0473	3-isopropylmalate dehydrogenase activity
HZ994_15885	COG2255	four-way junction helicase activity
HZ994_15895	COG3361	conserved protein (COG2071)
HZ994_15900	COG3424	synthase
HZ994_15915	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HZ994_15925	COG2003	Belongs to the UPF0758 family
HZ994_15930	COG1561	YicC-like family, N-terminal region
HZ994_15935	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
HZ994_15935	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HZ994_15940	COG0713	ATP synthesis coupled electron transport
HZ994_15960	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HZ994_15965	COG1034	ATP synthesis coupled electron transport
HZ994_16020	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HZ994_16040	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HZ994_16065	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HZ994_16080	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HZ994_16090	COG0505	Belongs to the CarA family
HZ994_16100	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HZ994_16110	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
HZ994_16115	COG3339	Conserved Protein
HZ994_16130	COG4152	abc transporter atp-binding protein
HZ994_16180	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HZ994_16205	COG2151	metal-sulfur cluster biosynthetic enzyme
HZ994_16215	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
HZ994_16220	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HZ994_16230	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HZ994_16230	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HZ994_16235	COG1678	Uncharacterized ACR, COG1678
HZ994_16250	COG0557	exoribonuclease II activity
HZ994_16265	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HZ994_16275	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HZ994_16280	COG1363	Peptidase, m42
HZ994_16295	COG0133	tryptophan synthase activity
HZ994_16310	COG2226	methyltransferase
HZ994_16315	COG3119	arylsulfatase activity
HZ994_16325	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HZ994_16325	COG1796	DNA polymerase
HZ994_16350	COG4591	ABC-type transport system involved in lipoprotein release permease component
HZ994_16395	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HZ994_16415	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HZ994_16430	COG0500	methyltransferase
HZ994_16435	COG3119	arylsulfatase activity
HZ994_16485	COG1858	cytochrome C peroxidase
HZ994_16490	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HZ994_16495	COG0483	inositol monophosphate 1-phosphatase activity
HZ994_16510	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HZ994_16520	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HZ994_16520	COG0551	DNA topoisomerase type I activity
HZ994_16525	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HZ994_16525	COG0758	DNA mediated transformation
HZ994_16535	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HZ994_16540	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HZ994_16560	COG0514	ATP-dependent DNA helicase (RecQ)
HZ994_16565	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
HZ994_16610	COG4585	Histidine kinase
HZ994_16615	COG2197	response regulator
HZ994_16620	COG2217	Heavy metal translocating P-type atpase
HZ994_16630	COG2132	Multicopper oxidase
HZ994_16655	COG4589	Belongs to the CDS family
HZ994_16705	COG0556	nucleotide-excision repair
HZ994_16710	COG1404	Belongs to the peptidase S8 family
HZ994_16755	COG1704	LemA family
HZ994_16760	COG0501	Belongs to the peptidase M48B family
HZ994_16770	COG0165	Argininosuccinate lyase
HZ994_16795	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
HZ994_16800	COG2124	cytochrome p450
HZ994_16805	COG3119	arylsulfatase activity
HZ994_16810	COG3119	arylsulfatase activity
HZ994_16820	COG2084	Dehydrogenase
HZ994_16825	COG0354	folic acid binding
HZ994_16840	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HZ994_16845	COG0058	SHG alpha-glucan phosphorylase activity
HZ994_16850	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HZ994_16855	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HZ994_16860	COG1595	DNA-templated transcription, initiation
HZ994_16875	COG3119	arylsulfatase activity
HZ994_16880	COG5434	Belongs to the glycosyl hydrolase 28 family
HZ994_16890	COG1609	Transcriptional regulator
HZ994_16890	COG2207	Transcriptional regulator
HZ994_16925	COG0745	RESPONSE REGULATOR receiver
HZ994_16930	COG2205	protein histidine kinase activity
HZ994_16950	COG0513	Belongs to the DEAD box helicase family
HZ994_16955	COG0142	geranyltranstransferase activity
HZ994_16960	COG0489	protein tyrosine kinase activity
HZ994_16970	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
HZ994_16985	COG0673	inositol 2-dehydrogenase activity
HZ994_16995	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HZ994_17000	COG1201	RNA secondary structure unwinding
HZ994_17005	COG0564	pseudouridine synthase activity
HZ994_17030	COG0131	Imidazoleglycerol-phosphate dehydratase
HZ994_17045	COG0195	Participates in both transcription termination and antitermination
HZ994_17050	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HZ994_17055	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HZ994_17070	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HZ994_17090	COG1595	DNA-templated transcription, initiation
HZ994_17095	COG0072	phenylalanine-tRNA ligase activity
HZ994_17175	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HZ994_17185	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
HZ994_17205	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HZ994_17225	COG0018	arginyl-trna synthetase
HZ994_17235	COG0181	hydroxymethylbilane synthase activity
HZ994_17275	COG1121	(ABC) transporter
HZ994_17280	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HZ994_17285	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HZ994_17290	COG3119	arylsulfatase activity
HZ994_17295	COG0504	CTP synthase activity
HZ994_17300	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
HZ994_17340	COG0563	adenylate kinase activity
HZ994_17345	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
HZ994_17355	COG2996	Protein conserved in bacteria
HZ994_17395	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HZ994_17420	COG0300	oxidoreductase activity
HZ994_17435	COG5002	protein histidine kinase activity
HZ994_17450	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HZ994_17490	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HZ994_17490	COG1017	nitric oxide dioxygenase activity
HZ994_17510	COG0445	tRNA wobble uridine modification
HZ994_17515	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HZ994_17520	COG0436	Aminotransferase
HZ994_17535	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HZ994_17540	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HZ994_17550	COG0300	oxidoreductase activity
HZ994_17555	COG5632	N-Acetylmuramoyl-L-alanine amidase
HZ994_17555	COG3409	Peptidoglycan-binding domain 1 protein
HZ994_17555	COG1388	LysM domain
HZ994_17565	COG1196	nuclear chromosome segregation
HZ994_17595	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HZ994_17600	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HZ994_17610	COG0297	glycogen (starch) synthase activity
HZ994_17630	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HZ994_17630	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HZ994_17645	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HZ994_17660	COG0095	Lipoate-protein ligase
HZ994_17675	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HZ994_17700	COG0842	Transport permease protein
HZ994_17700	COG1716	ATPase activity
HZ994_17700	COG1131	(ABC) transporter
HZ994_17725	COG0148	phosphopyruvate hydratase activity
HZ994_17765	COG0590	tRNA wobble adenosine to inosine editing
HZ994_17770	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HZ994_17785	COG1305	Transglutaminase-like
HZ994_17795	COG0714	Associated with various cellular activities
HZ994_17800	COG2096	Adenosyltransferase
HZ994_17830	COG0459	protein refolding
HZ994_17835	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HZ994_17840	COG0443	Heat shock 70 kDa protein
HZ994_17855	COG3977	Valine--pyruvate aminotransferase
HZ994_17865	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HZ994_17880	COG2197	response regulator
HZ994_17895	COG0436	Aminotransferase
HZ994_17910	COG1131	(ABC) transporter
HZ994_17930	COG0649	NAD binding
HZ994_17945	COG0860	N-Acetylmuramoyl-L-alanine amidase
HZ994_17945	COG1388	LysM domain
HZ994_17985	COG0714	Associated with various cellular activities
HZ994_18005	COG2304	oxidoreductase activity
HZ994_18020	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HZ994_18025	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HZ994_18040	COG0668	transmembrane transport
HZ994_18045	COG4974	Belongs to the 'phage' integrase family
HZ994_18080	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HZ994_18155	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HZ994_18175	COG0305	Participates in initiation and elongation during chromosome replication
HZ994_18230	COG1929	Belongs to the glycerate kinase type-1 family
HZ994_18235	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HZ994_18240	COG0193	aminoacyl-tRNA hydrolase activity
HZ994_18245	COG0360	Binds together with S18 to 16S ribosomal RNA
HZ994_18250	COG0629	single-stranded DNA binding
HZ994_18255	COG0540	Belongs to the ATCase OTCase family
HZ994_18265	COG0151	Belongs to the GarS family
HZ994_18270	COG1472	Belongs to the glycosyl hydrolase 3 family
HZ994_18275	COG1490	D-aminoacyl-tRNA deacylase activity
HZ994_18280	COG0305	Participates in initiation and elongation during chromosome replication
HZ994_18285	COG3119	arylsulfatase activity
HZ994_18295	COG1611	Belongs to the LOG family
HZ994_18300	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HZ994_18315	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
HZ994_18335	COG0732	type I restriction modification DNA specificity domain
HZ994_18340	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HZ994_18350	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
HZ994_18365	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
HZ994_18385	COG3119	arylsulfatase activity
HZ994_18400	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HZ994_18410	COG1176	ABC-type spermidine putrescine transport system, permease component I
HZ994_18415	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HZ994_18470	COG1530	ribonuclease E activity
HZ994_18490	COG1077	Cell shape determining protein MreB Mrl
HZ994_18500	COG0673	inositol 2-dehydrogenase activity
HZ994_18505	COG1012	belongs to the aldehyde dehydrogenase family
HZ994_18525	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HZ994_18530	COG0339	signal peptide processing
HZ994_18535	COG1968	undecaprenyl-diphosphatase activity
HZ994_18545	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HZ994_18550	COG0706	membrane insertase activity
HZ994_18565	COG0488	(ABC) transporter
HZ994_18570	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HZ994_18580	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HZ994_18615	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HZ994_18635	COG4585	Histidine kinase
HZ994_18640	COG2197	response regulator
HZ994_18645	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HZ994_18655	COG1546	Belongs to the CinA family
HZ994_18655	COG1058	Belongs to the CinA family
HZ994_18665	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HZ994_18670	COG3250	beta-galactosidase activity
HZ994_18685	COG4112	unkown
HZ994_18695	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HZ994_18705	COG1846	Transcriptional regulator
HZ994_18710	COG0254	rRNA binding
HZ994_18715	COG1073	alpha beta
HZ994_18725	COG4676	Protein conserved in bacteria
HZ994_18750	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HZ994_18770	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA