locus-tag	class	description
M6D76_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
M6D76_00010	COG0592	DNA-directed DNA polymerase activity
M6D76_00020	COG1187	pseudouridine synthase activity
M6D76_00035	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
M6D76_00060	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
M6D76_00065	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
M6D76_00080	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M6D76_00095	COG2186	Transcriptional regulator
M6D76_00100	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
M6D76_00120	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
M6D76_00125	COG0583	DNA-binding transcription factor activity
M6D76_00135	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
M6D76_00140	COG1802	Transcriptional regulator
M6D76_00145	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
M6D76_00150	COG2271	Major facilitator Superfamily
M6D76_00170	COG0559	Belongs to the binding-protein-dependent transport system permease family
M6D76_00185	COG0318	PFAM AMP-dependent synthetase and ligase
M6D76_00195	COG0596	Alpha beta hydrolase
M6D76_00195	COG0508	dehydrogenase complex catalyzes the overall conversion of
M6D76_00200	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M6D76_00220	COG0464	growth
M6D76_00250	COG3181	Tripartite tricarboxylate transporter family receptor
M6D76_00260	COG0697	spore germination
M6D76_00265	COG0583	DNA-binding transcription factor activity
M6D76_00275	COG3842	ATPase activity
M6D76_00285	COG0436	Aminotransferase
M6D76_00295	COG0523	cobalamin synthesis protein
M6D76_00350	COG1846	Transcriptional regulator
M6D76_00370	COG0179	Fumarylacetoacetate (FAA) hydrolase
M6D76_00375	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
M6D76_00380	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
M6D76_00390	COG4638	Rieske (2fe-2S)
M6D76_00450	COG1028	Short-chain dehydrogenase reductase Sdr
M6D76_00460	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
M6D76_00475	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
M6D76_00500	COG1595	DNA-templated transcription, initiation
M6D76_00505	COG4608	Belongs to the ABC transporter superfamily
M6D76_00510	COG0444	Belongs to the ABC transporter superfamily
M6D76_00515	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M6D76_00520	COG0601	transmembrane transport
M6D76_00530	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
M6D76_00535	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
M6D76_00550	COG1464	Belongs to the NlpA lipoprotein family
M6D76_00555	COG1464	Belongs to the NlpA lipoprotein family
M6D76_00560	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
M6D76_00565	COG2011	ABC-type metal ion transport system permease component
M6D76_00590	COG1464	Belongs to the NlpA lipoprotein family
M6D76_00605	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M6D76_00610	COG0431	NADPH-dependent FMN reductase
M6D76_00645	COG4149	molybdate abc transporter
M6D76_00660	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
M6D76_00665	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
M6D76_00675	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
M6D76_00695	COG0028	Belongs to the TPP enzyme family
M6D76_00700	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
M6D76_00720	COG3391	amine dehydrogenase activity
M6D76_00750	COG2922	Belongs to the Smg family
M6D76_00765	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
M6D76_00770	COG0183	Belongs to the thiolase family
M6D76_00775	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
M6D76_00780	COG1960	acyl-CoA dehydrogenase activity
M6D76_00800	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
M6D76_00810	COG0018	arginyl-trna synthetase
M6D76_00835	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
M6D76_00850	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
M6D76_00855	COG4774	siderophore transport
M6D76_00860	COG0066	3-isopropylmalate dehydratase activity
M6D76_00865	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
M6D76_00870	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
M6D76_00875	COG1804	L-carnitine dehydratase bile acid-inducible protein F
M6D76_00880	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
M6D76_00880	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
M6D76_00890	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
M6D76_00895	COG1335	isochorismatase
M6D76_00900	COG0583	DNA-binding transcription factor activity
M6D76_00920	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
M6D76_00925	COG1280	lysine exporter protein (LysE YggA)
M6D76_00930	COG0513	Belongs to the DEAD box helicase family
M6D76_00940	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
M6D76_00955	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
M6D76_00970	COG0154	amidase activity
M6D76_00985	COG0583	DNA-binding transcription factor activity
M6D76_01015	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
M6D76_01020	COG1127	ABC transporter
M6D76_01040	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
M6D76_01045	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
M6D76_01055	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
M6D76_01085	COG0583	DNA-binding transcription factor activity
M6D76_01105	COG3093	addiction module antidote protein HigA
M6D76_01120	COG1254	Belongs to the acylphosphatase family
M6D76_01130	COG2358	TRAP transporter, solute receptor (TAXI family
M6D76_01140	COG0564	pseudouridine synthase activity
M6D76_01145	COG0252	asparaginase activity
M6D76_01170	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
M6D76_01175	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
M6D76_01180	COG3181	Tripartite tricarboxylate transporter family receptor
M6D76_01200	COG0559	Belongs to the binding-protein-dependent transport system permease family
M6D76_01225	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M6D76_01240	COG0758	DNA mediated transformation
M6D76_01245	COG0242	peptide deformylase activity
M6D76_01250	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
M6D76_01255	COG0697	spore germination
M6D76_01285	COG4336	lyase activity
M6D76_01290	COG0583	DNA-binding transcription factor activity
M6D76_01295	COG0859	PFAM glycosyl transferase family 9
M6D76_01305	COG1278	Cold shock
M6D76_01310	COG1210	Utp--glucose-1-phosphate uridylyltransferase
M6D76_01315	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
M6D76_01320	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
M6D76_01320	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
M6D76_01330	COG1686	Belongs to the peptidase S11 family
M6D76_01340	COG2921	Belongs to the UPF0250 family
M6D76_01345	COG0321	lipoyl(octanoyl) transferase activity
M6D76_01350	COG1024	Enoyl-CoA hydratase
M6D76_01355	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
M6D76_01365	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
M6D76_01410	COG0826	peptidase U32
M6D76_01420	COG3154	lipid carrier protein
M6D76_01445	COG0134	indole-3-glycerol-phosphate synthase activity
M6D76_01450	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
M6D76_01455	COG0512	Glutamine amidotransferase of anthranilate synthase
M6D76_01465	COG0546	phosphoglycolate phosphatase activity
M6D76_01475	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
M6D76_01480	COG2967	ApaG domain
M6D76_01485	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
M6D76_01490	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M6D76_01495	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
M6D76_01505	COG0840	transmembrane signaling receptor activity
M6D76_01515	COG1028	Short-chain dehydrogenase reductase Sdr
M6D76_01520	COG3433	isochorismatase activity
M6D76_01520	COG1535	isochorismatase
M6D76_01525	COG1169	isochorismate synthase
M6D76_01540	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M6D76_01540	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
M6D76_01545	COG3433	isochorismatase activity
M6D76_01545	COG1535	isochorismatase
M6D76_01550	COG1021	2,3-dihydroxybenzoate-AMP ligase
M6D76_01580	COG0683	leucine binding
M6D76_01595	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
M6D76_01610	COG1250	3-hydroxyacyl-CoA dehydrogenase
M6D76_01630	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
M6D76_01635	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M6D76_01640	COG2819	hydrolase of the alpha beta superfamily
M6D76_01645	COG0513	Belongs to the DEAD box helicase family
M6D76_01650	COG2814	Major facilitator Superfamily
M6D76_01660	COG0583	DNA-binding transcription factor activity
M6D76_01670	COG1253	flavin adenine dinucleotide binding
M6D76_01695	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
M6D76_01705	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
M6D76_01725	COG2311	Membrane
M6D76_01735	COG1132	(ABC) transporter
M6D76_01745	COG0456	acetyltransferase
M6D76_01765	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
M6D76_01780	COG0402	S-adenosylhomocysteine deaminase activity
M6D76_01785	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
M6D76_01790	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
M6D76_01800	COG0583	DNA-binding transcription factor activity
M6D76_01805	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M6D76_01810	COG1126	abc transporter atp-binding protein
M6D76_01815	COG0765	amino acid transport
M6D76_01820	COG0765	amino acid transport
M6D76_01825	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
M6D76_01835	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
M6D76_01850	COG3391	amine dehydrogenase activity
M6D76_01860	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
M6D76_01885	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
M6D76_01890	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
M6D76_01895	COG0210	DNA helicase
M6D76_01910	COG0067	glutamate synthase
M6D76_01910	COG0069	glutamate synthase activity
M6D76_01910	COG0070	glutamate synthase
M6D76_01915	COG1024	Enoyl-CoA hydratase
M6D76_01925	COG1804	L-carnitine dehydratase bile acid-inducible protein F
M6D76_01930	COG1250	3-hydroxyacyl-CoA dehydrogenase
M6D76_01970	COG2918	glutathione biosynthetic process
M6D76_01985	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
M6D76_01995	COG2223	nitrite transmembrane transporter activity
M6D76_02000	COG2860	membrane
M6D76_02005	COG1346	cytolysis
M6D76_02020	COG0251	oxidation-reduction process
M6D76_02045	COG1280	lysine exporter protein (LysE YggA)
M6D76_02055	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
M6D76_02070	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
M6D76_02085	COG2096	Adenosyltransferase
M6D76_02100	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
M6D76_02105	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
M6D76_02115	COG0523	cobalamin synthesis protein
M6D76_02120	COG0735	belongs to the Fur family
M6D76_02135	COG1108	ABC-type Mn2 Zn2 transport systems permease components
M6D76_02140	COG0803	Belongs to the bacterial solute-binding protein 9 family
M6D76_02145	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
M6D76_02155	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
M6D76_02160	COG1560	Kdo2-lipid A biosynthetic process
M6D76_02170	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
M6D76_02175	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
M6D76_02180	COG1950	PFAM Membrane protein of
M6D76_02215	COG0275	rRNA processing
M6D76_02220	COG0730	response to heat
M6D76_02225	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
M6D76_02230	COG0129	dihydroxy-acid dehydratase activity
M6D76_02240	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
M6D76_02250	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
M6D76_02250	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
M6D76_02255	COG0154	amidase activity
M6D76_02265	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
M6D76_02270	COG0628	permease
M6D76_02280	COG1192	Involved in chromosome partitioning
M6D76_02295	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
M6D76_02300	COG0656	L-ascorbic acid biosynthetic process
M6D76_02305	COG2814	Major facilitator Superfamily
M6D76_02310	COG0583	DNA-binding transcription factor activity
M6D76_02320	COG3685	Protein conserved in bacteria
M6D76_02345	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
M6D76_02350	COG2814	Major facilitator Superfamily
M6D76_02355	COG0655	NAD(P)H dehydrogenase (quinone) activity
M6D76_02360	COG0583	DNA-binding transcription factor activity
M6D76_02375	COG4774	siderophore transport
M6D76_02380	COG4607	ABC-type enterochelin transport system periplasmic component
M6D76_02385	COG4604	ABC transporter, ATP-binding protein
M6D76_02390	COG4605	iron ion homeostasis
M6D76_02395	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M6D76_02400	COG1132	(ABC) transporter
M6D76_02405	COG2375	cellular response to nickel ion
M6D76_02405	COG1132	(ABC) transporter
M6D76_02410	COG0277	FAD linked oxidase domain protein
M6D76_02415	COG1304	FMN binding
M6D76_02420	COG2186	Transcriptional regulator
M6D76_02440	COG1609	Transcriptional regulator
M6D76_02445	COG1522	sequence-specific DNA binding
M6D76_02450	COG3844	kynureninase activity
M6D76_02455	COG1113	amino acid transport
M6D76_02480	COG1349	DNA-binding transcription factor activity
M6D76_02500	COG0395	ABC-type sugar transport system, permease component
M6D76_02525	COG0861	Integral membrane protein TerC family
M6D76_02530	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
M6D76_02540	COG1671	Belongs to the UPF0178 family
M6D76_02550	COG1418	mRNA catabolic process
M6D76_02560	COG4948	Mandelate Racemase Muconate Lactonizing
M6D76_02570	COG0477	Major facilitator Superfamily
M6D76_02585	COG0154	amidase activity
M6D76_02595	COG0583	DNA-binding transcription factor activity
M6D76_02620	COG0326	Molecular chaperone. Has ATPase activity
M6D76_02625	COG4774	siderophore transport
M6D76_02630	COG3128	pkhd-type hydroxylase
M6D76_02640	COG3023	N-Acetylmuramoyl-L-alanine amidase
M6D76_02655	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
M6D76_02660	COG1652	LysM domain
M6D76_02675	COG0220	tRNA (guanine-N7-)-methyltransferase activity
M6D76_02695	COG1535	isochorismatase
M6D76_02695	COG3433	isochorismatase activity
M6D76_02720	COG0583	DNA-binding transcription factor activity
M6D76_02730	COG0387	Pfam Sodium calcium exchanger
M6D76_02745	COG0477	Major facilitator Superfamily
M6D76_02750	COG0235	Class ii aldolase
M6D76_02765	COG3391	amine dehydrogenase activity
M6D76_02770	COG0590	tRNA wobble adenosine to inosine editing
M6D76_02775	COG3257	ureidoglycine aminohydrolase activity
M6D76_02780	COG0583	DNA-binding transcription factor activity
M6D76_02785	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
M6D76_02790	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M6D76_02790	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M6D76_02800	COG0489	protein tyrosine kinase activity
M6D76_02825	COG2081	HI0933 family
M6D76_02830	COG0509	glycine decarboxylation via glycine cleavage system
M6D76_02840	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
M6D76_02845	COG1765	OsmC-like protein
M6D76_02850	COG3278	Belongs to the heme-copper respiratory oxidase family
M6D76_02875	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
M6D76_02880	COG0469	pyruvate kinase activity
M6D76_02885	COG3193	protein, possibly involved in utilization of glycolate and propanediol
M6D76_02895	COG2084	Dehydrogenase
M6D76_02900	COG3622	Belongs to the hyi family
M6D76_02905	COG3960	tartronate-semialdehyde synthase activity
M6D76_02910	COG0583	DNA-binding transcription factor activity
M6D76_02920	COG2233	PERMEase
M6D76_02925	COG1942	4-Oxalocrotonate Tautomerase
M6D76_02930	COG0235	Class ii aldolase
M6D76_02935	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
M6D76_02940	COG3648	Uricase
M6D76_02940	COG3195	allantoin biosynthetic process
M6D76_02950	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
M6D76_02955	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
M6D76_02970	COG0438	transferase activity, transferring glycosyl groups
M6D76_02975	COG0438	transferase activity, transferring glycosyl groups
M6D76_02980	COG0438	transferase activity, transferring glycosyl groups
M6D76_02990	COG0277	FAD linked oxidase domain protein
M6D76_03000	COG0179	Fumarylacetoacetate (FAA) hydrolase
M6D76_03005	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
M6D76_03015	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M6D76_03025	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
M6D76_03035	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
M6D76_03050	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
M6D76_03055	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
M6D76_03060	COG0193	aminoacyl-tRNA hydrolase activity
M6D76_03070	COG0012	GTP binding
M6D76_03080	COG1024	Enoyl-CoA hydratase
M6D76_03085	COG0367	asparagine synthase
M6D76_03100	COG0488	(ABC) transporter
M6D76_03115	COG0288	reversible hydration of carbon dioxide
M6D76_03120	COG0583	DNA-binding transcription factor activity
M6D76_03135	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
M6D76_03140	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
M6D76_03150	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
M6D76_03160	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M6D76_03165	COG3088	subunit of a heme lyase
M6D76_03170	COG4235	cytochrome complex assembly
M6D76_03175	COG0785	Cytochrome C biogenesis protein
M6D76_03185	COG2169	Transcriptional regulator
M6D76_03185	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
M6D76_03205	COG0559	Belongs to the binding-protein-dependent transport system permease family
M6D76_03215	COG0411	ABC transporter
M6D76_03225	COG1858	cytochrome C peroxidase
M6D76_03230	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
M6D76_03235	COG1959	2 iron, 2 sulfur cluster binding
M6D76_03240	COG2346	COG2346, Truncated hemoglobins
M6D76_03245	COG0463	Glycosyl transferase, family 2
M6D76_03285	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
M6D76_03290	COG3383	formate dehydrogenase (NAD+) activity
M6D76_03305	COG1910	domain protein
M6D76_03310	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
M6D76_03320	COG0303	'Molybdopterin
M6D76_03325	COG0521	Mo-molybdopterin cofactor biosynthetic process
M6D76_03330	COG0314	molybdopterin synthase activity
M6D76_03340	COG0315	cyclic pyranopterin monophosphate synthase activity
M6D76_03380	COG0678	peroxiredoxin activity
M6D76_03395	COG0697	spore germination
M6D76_03400	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
M6D76_03465	COG0815	Transfers the fatty acyl group on membrane lipoproteins
M6D76_03470	COG4535	Mg2 and Co2 transporter CorC
M6D76_03475	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
M6D76_03480	COG1702	phosphate starvation-inducible protein PhoH
M6D76_03485	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
M6D76_03495	COG0024	Methionine aminopeptidase
M6D76_03500	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
M6D76_03505	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
M6D76_03510	COG1862	Preprotein translocase
M6D76_03515	COG0343	queuine tRNA-ribosyltransferase activity
M6D76_03520	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
M6D76_03525	COG2027	D-alanyl-D-alanine carboxypeptidase
M6D76_03530	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
M6D76_03540	COG4575	ribosome binding
M6D76_03555	COG0583	DNA-binding transcription factor activity
M6D76_03570	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M6D76_03585	COG0154	amidase activity
M6D76_03595	COG0477	Major facilitator Superfamily
M6D76_03605	COG0346	lactoylglutathione lyase activity
M6D76_03610	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
M6D76_03620	COG0436	Aminotransferase
M6D76_03630	COG0280	phosphate acetyltransferase
M6D76_03630	COG0281	malic enzyme
M6D76_03640	COG2732	(Barnase) inhibitor
M6D76_03645	COG1385	rRNA (uridine-N3-)-methyltransferase activity
M6D76_03650	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
M6D76_03655	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
M6D76_03660	COG0126	phosphoglycerate kinase activity
M6D76_03685	COG0521	Mo-molybdopterin cofactor biosynthetic process
M6D76_03695	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
M6D76_03700	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
M6D76_03705	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
M6D76_03710	COG0009	L-threonylcarbamoyladenylate synthase
M6D76_03715	COG0596	Alpha beta hydrolase
M6D76_03720	COG1012	belongs to the aldehyde dehydrogenase family
M6D76_03720	COG2030	dehydratase
M6D76_03725	COG1960	acyl-CoA dehydrogenase activity
M6D76_03735	COG0405	Gamma-glutamyltransferase
M6D76_03745	COG0579	oxidoreductase
M6D76_03750	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
M6D76_03755	COG0259	pyridoxamine-phosphate oxidase activity
M6D76_03765	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
M6D76_03780	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
M6D76_03785	COG1215	transferase activity, transferring glycosyl groups
M6D76_03795	COG0488	(ABC) transporter
M6D76_03815	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
M6D76_03820	COG2894	cell division
M6D76_03830	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
M6D76_03835	COG1271	oxidase subunit
M6D76_03840	COG1294	oxidase, subunit
M6D76_03845	COG0038	chloride channel
M6D76_03855	COG0514	ATP-dependent DNA helicase (RecQ)
M6D76_03860	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
M6D76_03865	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
M6D76_03870	COG0633	Ferredoxin
M6D76_03875	COG0488	(ABC) transporter
M6D76_03885	COG2001	Belongs to the MraZ family
M6D76_03890	COG0275	rRNA processing
M6D76_03895	COG3116	cell division
M6D76_03905	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
M6D76_03910	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
M6D76_03915	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
M6D76_03925	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
M6D76_03930	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
M6D76_03935	COG1181	Belongs to the D-alanine--D-alanine ligase family
M6D76_03940	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
M6D76_03955	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
M6D76_03965	COG0739	heme binding
M6D76_03965	COG0741	lytic transglycosylase activity
M6D76_03965	COG1196	nuclear chromosome segregation
M6D76_03970	COG0653	protein targeting
M6D76_03980	COG2239	Acts as a magnesium transporter
M6D76_03990	COG1473	amidohydrolase
M6D76_03995	COG0318	PFAM AMP-dependent synthetase and ligase
M6D76_04005	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M6D76_04005	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
M6D76_04020	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
M6D76_04025	COG2011	ABC-type metal ion transport system permease component
M6D76_04035	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M6D76_04040	COG0765	amino acid transport
M6D76_04045	COG1126	abc transporter atp-binding protein
M6D76_04065	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
M6D76_04070	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
M6D76_04075	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
M6D76_04080	COG0700	Nucleoside recognition
M6D76_04095	COG0204	Acyl-transferase
M6D76_04100	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
M6D76_04105	COG0751	glycine-tRNA ligase activity
M6D76_04110	COG0752	glycyl-tRNA synthetase alpha subunit
M6D76_04130	COG1309	transcriptional regulator
M6D76_04140	COG2814	Major facilitator Superfamily
M6D76_04155	COG1573	uracil-dna glycosylase
M6D76_04160	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
M6D76_04165	COG0617	tRNA 3'-terminal CCA addition
M6D76_04175	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
M6D76_04180	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
M6D76_04185	COG1953	Uracil, thiamine, allantoin
M6D76_04190	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
M6D76_04195	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
M6D76_04200	COG0586	Pfam SNARE associated Golgi protein
M6D76_04205	COG0860	N-Acetylmuramoyl-L-alanine amidase
M6D76_04210	COG0802	atpase or kinase
M6D76_04220	COG3181	Tripartite tricarboxylate transporter family receptor
M6D76_04225	COG0281	malic enzyme
M6D76_04225	COG0280	phosphate acetyltransferase
M6D76_04230	COG0583	DNA-binding transcription factor activity
M6D76_04235	COG1012	belongs to the aldehyde dehydrogenase family
M6D76_04240	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
M6D76_04260	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
M6D76_04285	COG1733	regulation of RNA biosynthetic process
M6D76_04290	COG2910	NAD(P)H-binding
M6D76_04300	COG2223	nitrite transmembrane transporter activity
M6D76_04305	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
M6D76_04310	COG4974	Belongs to the 'phage' integrase family
M6D76_04315	COG0725	ABC transporter, periplasmic molybdate-binding protein
M6D76_04320	COG4149	molybdate abc transporter
M6D76_04325	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
M6D76_04340	COG1074	ATP-dependent DNA helicase activity
M6D76_04375	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
M6D76_04395	COG3391	amine dehydrogenase activity
M6D76_04400	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
M6D76_04405	COG0505	Belongs to the CarA family
M6D76_04410	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
M6D76_04430	COG2233	PERMEase
M6D76_04435	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
M6D76_04440	COG1534	Rna-binding protein
M6D76_04445	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
M6D76_04450	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
M6D76_04460	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
M6D76_04470	COG0248	Ppx GppA phosphatase
M6D76_04475	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
M6D76_04495	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
M6D76_04500	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
M6D76_04550	COG1231	oxidoreductase activity
M6D76_04555	COG2010	Cytochrome c
M6D76_04560	COG2323	membrane
M6D76_04575	COG1368	sulfuric ester hydrolase activity
M6D76_04605	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
M6D76_04610	COG3327	negative regulation of DNA-templated transcription, initiation
M6D76_04615	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
M6D76_04630	COG0009	L-threonylcarbamoyladenylate synthase
M6D76_04635	COG1994	Peptidase M50
M6D76_04640	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
M6D76_04645	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
M6D76_04660	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
M6D76_04670	COG0156	8-amino-7-oxononanoate synthase activity
M6D76_04675	COG2124	cytochrome p450
M6D76_04685	COG3135	benzoate transporter
M6D76_04695	COG2850	peptidyl-arginine hydroxylation
M6D76_04705	COG3391	amine dehydrogenase activity
M6D76_04715	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M6D76_04720	COG0577	efflux transmembrane transporter activity
M6D76_04720	COG1136	(ABC) transporter
M6D76_04725	COG1538	Outer membrane efflux protein
M6D76_04730	COG0363	glucosamine-6-phosphate deaminase activity
M6D76_04735	COG1132	(ABC) transporter
M6D76_04745	COG3181	Tripartite tricarboxylate transporter family receptor
M6D76_04755	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M6D76_04765	COG0668	transmembrane transport
M6D76_04775	COG3321	synthase
M6D76_04775	COG0604	alcohol dehydrogenase
M6D76_04775	COG1028	Short-chain dehydrogenase reductase Sdr
M6D76_04810	COG0154	amidase activity
M6D76_04815	COG2031	fatty acid transporter
M6D76_04830	COG0483	inositol monophosphate 1-phosphatase activity
M6D76_04835	COG1253	flavin adenine dinucleotide binding
M6D76_04840	COG1968	undecaprenyl-diphosphatase activity
M6D76_04860	COG0215	cysteine-tRNA ligase activity
M6D76_04870	COG0825	malonyl-CoA metabolic process
M6D76_04875	COG0037	tRNA processing
M6D76_04900	COG0330	HflC and HflK could
M6D76_04915	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
M6D76_04935	COG4208	sulfate ABC transporter
M6D76_04940	COG3842	ATPase activity
M6D76_04950	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
M6D76_04980	COG4773	Receptor
M6D76_04995	COG1304	FMN binding
M6D76_05000	COG0435	Glutathione S-transferase
M6D76_05005	COG0655	NAD(P)H dehydrogenase (quinone) activity
M6D76_05020	COG2094	Belongs to the DNA glycosylase MPG family
M6D76_05025	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
M6D76_05030	COG2363	Small membrane protein
M6D76_05035	COG0598	Magnesium transport protein CorA
M6D76_05040	COG1960	acyl-CoA dehydrogenase activity
M6D76_05050	COG0747	negative chemotaxis
M6D76_05060	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M6D76_05065	COG4172	Belongs to the ABC transporter superfamily
M6D76_05075	COG3284	Transcriptional regulator
M6D76_05080	COG1012	belongs to the aldehyde dehydrogenase family
M6D76_05085	COG1454	alcohol dehydrogenase
M6D76_05115	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
M6D76_05125	COG0183	Belongs to the thiolase family
M6D76_05140	COG1028	Short-chain dehydrogenase reductase Sdr
M6D76_05145	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
M6D76_05170	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
M6D76_05200	COG3829	transcription factor binding
M6D76_05220	COG0039	L-malate dehydrogenase activity
M6D76_05225	COG2188	Transcriptional regulator
M6D76_05230	COG2009	succinate dehydrogenase
M6D76_05240	COG1053	succinate dehydrogenase
M6D76_05245	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
M6D76_05250	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
M6D76_05255	COG0372	Belongs to the citrate synthase family
M6D76_05260	COG2186	Transcriptional regulator
M6D76_05265	COG1620	l-lactate permease
M6D76_05270	COG0038	chloride channel
M6D76_05280	COG0280	phosphate acetyltransferase
M6D76_05280	COG0281	malic enzyme
M6D76_05285	COG0567	Dehydrogenase, E1 component
M6D76_05290	COG0508	dehydrogenase complex catalyzes the overall conversion of
M6D76_05295	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M6D76_05300	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
M6D76_05320	COG2183	response to ionizing radiation
M6D76_05325	COG1199	ATP-dependent helicase activity
M6D76_05335	COG1733	regulation of RNA biosynthetic process
M6D76_05350	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M6D76_05350	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
M6D76_05355	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
M6D76_05380	COG0564	pseudouridine synthase activity
M6D76_05390	COG3243	poly(R)-hydroxyalkanoic acid synthase
M6D76_05395	COG1028	Short-chain dehydrogenase reductase Sdr
M6D76_05400	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
M6D76_05435	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
M6D76_05440	COG1187	pseudouridine synthase activity
M6D76_05445	COG0779	Required for maturation of 30S ribosomal subunits
M6D76_05450	COG0195	Participates in both transcription termination and antitermination
M6D76_05450	COG2251	uridine kinase activity
M6D76_05460	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
M6D76_05465	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
M6D76_05470	COG1217	gtp-binding protein TYPA
M6D76_05475	COG0446	pyridine nucleotide-disulphide oxidoreductase
M6D76_05485	COG4160	amino acid transport
M6D76_05490	COG4215	(ABC) transporter
M6D76_05510	COG1283	sodium-dependent phosphate transmembrane transporter activity
M6D76_05520	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
M6D76_05540	COG0501	Belongs to the peptidase M48B family
M6D76_05560	COG1722	exodeoxyribonuclease VII activity
M6D76_05565	COG0142	geranyltranstransferase activity
M6D76_05570	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
M6D76_05575	COG1469	GTP cyclohydrolase I activity
M6D76_05580	COG0360	Binds together with S18 to 16S ribosomal RNA
M6D76_05585	COG2965	DNA replication, synthesis of RNA primer
M6D76_05590	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
M6D76_05600	COG0305	Participates in initiation and elongation during chromosome replication
M6D76_05610	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
M6D76_05615	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
M6D76_05620	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
M6D76_05630	COG0436	Aminotransferase
M6D76_05645	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
M6D76_05650	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
M6D76_05655	COG1562	ergosterol biosynthetic process
M6D76_05660	COG1562	ergosterol biosynthetic process
M6D76_05665	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
M6D76_05670	COG1028	Short-chain dehydrogenase reductase Sdr
M6D76_05695	COG3842	ATPase activity
M6D76_05700	COG1176	ABC-type spermidine putrescine transport system, permease component I
M6D76_05705	COG1177	transmembrane transport
M6D76_05710	COG1393	Belongs to the ArsC family
M6D76_05715	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
M6D76_05720	COG0704	Plays a role in the regulation of phosphate uptake
M6D76_05725	COG5001	Diguanylate cyclase
M6D76_05725	COG4251	negative regulation of phosphorylation
M6D76_05725	COG2203	Gaf domain
M6D76_05725	COG3706	GGDEF domain
M6D76_05730	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
M6D76_05735	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
M6D76_05735	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
M6D76_05740	COG1643	Atp-dependent helicase
M6D76_05750	COG0438	transferase activity, transferring glycosyl groups
M6D76_05755	COG0726	polysaccharide deacetylase
M6D76_05770	COG0438	transferase activity, transferring glycosyl groups
M6D76_05795	COG1132	(ABC) transporter
M6D76_05845	COG2186	Transcriptional regulator
M6D76_05850	COG0277	FAD linked oxidase domain protein
M6D76_05855	COG0277	FAD linked oxidase domain protein
M6D76_05860	COG0247	lactate metabolic process
M6D76_05885	COG1012	belongs to the aldehyde dehydrogenase family
M6D76_05930	COG0628	permease
M6D76_05935	COG1283	sodium-dependent phosphate transmembrane transporter activity
M6D76_05950	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
M6D76_05960	COG0697	spore germination
M6D76_05980	COG3094	Invasion gene expression up-regulator, SirB
M6D76_05990	COG0640	Transcriptional regulator
M6D76_06015	COG0659	secondary active sulfate transmembrane transporter activity
M6D76_06020	COG1262	PFAM Formylglycine-generating sulfatase enzyme
M6D76_06030	COG2314	TM2 domain
M6D76_06035	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
M6D76_06040	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
M6D76_06045	COG0791	NLP P60 protein
M6D76_06065	COG1360	Flagellar Motor Protein
M6D76_06075	COG0835	chemotaxis
M6D76_06080	COG0840	transmembrane signaling receptor activity
M6D76_06085	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
M6D76_06095	COG0745	RESPONSE REGULATOR receiver
M6D76_06100	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
M6D76_06110	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
M6D76_06135	COG1815	bacterial-type flagellum-dependent cell motility
M6D76_06140	COG1558	bacterial-type flagellum-dependent cell motility
M6D76_06145	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
M6D76_06185	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
M6D76_06210	COG2176	DNA-directed DNA polymerase activity
M6D76_06220	COG1987	bacterial-type flagellum assembly
M6D76_06235	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
M6D76_06245	COG1580	Controls the rotational direction of flagella during chemotaxis
M6D76_06260	COG1157	protein secretion by the type III secretion system
M6D76_06275	COG1766	The M ring may be actively involved in energy transduction
M6D76_06280	COG1677	Flagellar hook-basal body complex protein FliE
M6D76_06285	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
M6D76_06310	COG1334	flagellar protein FlaG
M6D76_06315	COG1191	sigma factor activity
M6D76_06360	COG1136	(ABC) transporter
M6D76_06370	COG1262	PFAM Formylglycine-generating sulfatase enzyme
M6D76_06390	COG2733	membrane
M6D76_06395	COG0840	transmembrane signaling receptor activity
M6D76_06400	COG0840	transmembrane signaling receptor activity
M6D76_06415	COG3181	Tripartite tricarboxylate transporter family receptor
M6D76_06425	COG2610	gluconate transmembrane transporter activity
M6D76_06470	COG1538	Outer membrane efflux protein
M6D76_06475	COG4521	taurine ABC transporter
M6D76_06480	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
M6D76_06485	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
M6D76_06490	COG1028	Short-chain dehydrogenase reductase Sdr
M6D76_06525	COG2824	Alkylphosphonate utilization operon protein PhnA
M6D76_06540	COG4771	TonB-dependent receptor
M6D76_06545	COG1858	cytochrome C peroxidase
M6D76_06555	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
M6D76_06565	COG1113	amino acid transport
M6D76_06585	COG0583	DNA-binding transcription factor activity
M6D76_06590	COG3755	Protein conserved in bacteria
M6D76_06595	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
M6D76_06635	COG0446	pyridine nucleotide-disulphide oxidoreductase
M6D76_06660	COG1278	Cold shock
M6D76_06665	COG0642	Histidine kinase
M6D76_06675	COG3278	Belongs to the heme-copper respiratory oxidase family
M6D76_06690	COG3258	Cytochrome c
M6D76_06700	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
M6D76_06705	COG4774	siderophore transport
M6D76_06740	COG0025	NhaP-type Na H and K H
M6D76_06755	COG1289	transmembrane transporter activity
M6D76_06760	COG2252	PERMEase
M6D76_06780	COG1999	signal sequence binding
M6D76_06790	COG0069	glutamate synthase activity
M6D76_06800	COG1846	Transcriptional regulator
M6D76_06805	COG1546	Belongs to the CinA family
M6D76_06805	COG1058	Belongs to the CinA family
M6D76_06810	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
M6D76_06850	COG1028	Short-chain dehydrogenase reductase Sdr
M6D76_06860	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
M6D76_06860	COG3264	Mechanosensitive ion channel
M6D76_06865	COG3264	Mechanosensitive ion channel
M6D76_06865	COG1196	nuclear chromosome segregation
M6D76_06870	COG0477	Major facilitator Superfamily
M6D76_06885	COG1396	sequence-specific DNA binding
M6D76_06890	COG3437	response regulator, receiver
M6D76_06895	COG2198	Histidine kinase
M6D76_06895	COG2205	protein histidine kinase activity
M6D76_06895	COG0784	Response regulator, receiver
M6D76_06900	COG2239	Acts as a magnesium transporter
M6D76_06910	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
M6D76_06915	COG1490	D-aminoacyl-tRNA deacylase activity
M6D76_06930	COG0456	acetyltransferase
M6D76_06940	COG0501	Belongs to the peptidase M48B family
M6D76_07055	COG3772	lysozyme
M6D76_07105	COG2199	diguanylate cyclase activity
M6D76_07120	COG1522	sequence-specific DNA binding
M6D76_07125	COG0626	cystathionine gamma-synthase activity
M6D76_07135	COG0494	nUDIX hydrolase
M6D76_07140	COG2832	Protein of unknown function (DUF454)
M6D76_07150	COG0137	argininosuccinate synthase activity
M6D76_07155	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
M6D76_07180	COG1609	Transcriptional regulator
M6D76_07195	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
M6D76_07200	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
M6D76_07205	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
M6D76_07210	COG2205	protein histidine kinase activity
M6D76_07215	COG0745	RESPONSE REGULATOR receiver
M6D76_07220	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
M6D76_07230	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
M6D76_07235	COG0268	Binds directly to 16S ribosomal RNA
M6D76_07240	COG0728	peptidoglycan biosynthetic process
M6D76_07250	COG0563	adenylate kinase activity
M6D76_07255	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
M6D76_07260	COG2835	tetraacyldisaccharide 4'-kinase activity
M6D76_07265	COG1663	tetraacyldisaccharide 4'-kinase activity
M6D76_07270	COG0848	biopolymer transport protein
M6D76_07275	COG0811	peptide transport
M6D76_07280	COG1570	exodeoxyribonuclease VII activity
M6D76_07285	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
M6D76_07300	COG0183	Belongs to the thiolase family
M6D76_07310	COG1278	Cold shock
M6D76_07315	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
M6D76_07320	COG0542	response to heat
M6D76_07325	COG2995	paraquat-inducible protein a
M6D76_07330	COG3008	intermembrane lipid transfer
M6D76_07330	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
M6D76_07350	COG0559	Belongs to the binding-protein-dependent transport system permease family
M6D76_07375	COG1028	Short-chain dehydrogenase reductase Sdr
M6D76_07385	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
M6D76_07390	COG0756	dUTP diphosphatase activity
M6D76_07400	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
M6D76_07405	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
M6D76_07410	COG0196	riboflavin kinase activity
M6D76_07415	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
M6D76_07420	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
M6D76_07420	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
M6D76_07430	COG0210	DNA helicase
M6D76_07485	COG0488	(ABC) transporter
M6D76_07490	COG2890	protein-(glutamine-N5) methyltransferase activity
M6D76_07495	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
M6D76_07500	COG2171	N-acyltransferase activity
M6D76_07510	COG2207	Transcriptional regulator
M6D76_07520	COG3273	potassium ion transport
M6D76_07520	COG0471	metal ion transport
M6D76_07560	COG0789	Transcriptional regulator
M6D76_07575	COG1804	L-carnitine dehydratase bile acid-inducible protein F
M6D76_07580	COG0544	peptidyl-prolyl cis-trans isomerase activity
M6D76_07585	COG0740	serine-type endopeptidase activity
M6D76_07595	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
M6D76_07615	COG0556	nucleotide-excision repair
M6D76_07620	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
M6D76_07630	COG1104	cysteine desulfurase activity
M6D76_07640	COG0316	Belongs to the HesB IscA family
M6D76_07650	COG3181	Tripartite tricarboxylate transporter family receptor
M6D76_07655	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
M6D76_07660	COG4221	oxidoreductase activity
M6D76_07670	COG0840	transmembrane signaling receptor activity
M6D76_07675	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
M6D76_07680	COG0697	spore germination
M6D76_07685	COG0385	Bile acid
M6D76_07695	COG2831	hemolysin activation secretion protein
M6D76_07700	COG3210	domain, Protein
M6D76_07725	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
M6D76_07740	COG1136	(ABC) transporter
M6D76_07745	COG0084	hydrolase, TatD family'
M6D76_07760	COG0613	PHP domain protein
M6D76_07770	COG0047	phosphoribosylformylglycinamidine synthase activity
M6D76_07770	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
M6D76_07800	COG0518	GMP synthase (glutamine-hydrolyzing) activity
M6D76_07800	COG0519	Catalyzes the synthesis of GMP from XMP
M6D76_07805	COG0582	viral genome integration into host DNA
M6D76_07870	COG4804	nuclease activity
M6D76_07935	COG0583	DNA-binding transcription factor activity
M6D76_07950	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
M6D76_07960	COG1960	acyl-CoA dehydrogenase activity
M6D76_07970	COG2378	regulation of single-species biofilm formation
M6D76_07975	COG0523	cobalamin synthesis protein
M6D76_07980	COG1469	GTP cyclohydrolase I activity
M6D76_07985	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
M6D76_07995	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
M6D76_08000	COG0735	belongs to the Fur family
M6D76_08005	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
M6D76_08035	COG0745	RESPONSE REGULATOR receiver
M6D76_08040	COG2207	Transcriptional regulator
M6D76_08060	COG0583	DNA-binding transcription factor activity
M6D76_08065	COG1289	transmembrane transporter activity
M6D76_08085	COG1942	4-Oxalocrotonate Tautomerase
M6D76_08100	COG2070	2-Nitropropane dioxygenase
M6D76_08135	COG1309	transcriptional regulator
M6D76_08150	COG0625	glutathione transferase activity
M6D76_08155	COG0583	DNA-binding transcription factor activity
M6D76_08175	COG2816	NAD+ diphosphatase activity
M6D76_08180	COG0625	glutathione transferase activity
M6D76_08185	COG0740	serine-type endopeptidase activity
M6D76_08235	COG1804	L-carnitine dehydratase bile acid-inducible protein F
M6D76_08245	COG1960	acyl-CoA dehydrogenase activity
M6D76_08275	COG0640	Transcriptional regulator
M6D76_08300	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
M6D76_08325	COG3485	protocatechuate 3,4-dioxygenase
M6D76_08335	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
M6D76_08340	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
M6D76_08350	COG3135	benzoate transporter
M6D76_08355	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
M6D76_08360	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
M6D76_08370	COG4555	ABC transporter
M6D76_08380	COG2197	response regulator
M6D76_08385	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
M6D76_08410	COG1846	Transcriptional regulator
M6D76_08415	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M6D76_08420	COG2271	Major facilitator Superfamily
M6D76_08430	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
M6D76_08440	COG0697	spore germination
M6D76_08465	COG3842	ATPase activity
M6D76_08490	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
M6D76_08495	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
M6D76_08500	COG0667	Aldo Keto reductase
M6D76_08520	COG0582	viral genome integration into host DNA
M6D76_08695	COG3728	DNA packaging
M6D76_08695	COG5484	DNA packaging
M6D76_08700	COG5410	chromosome segregation
M6D76_08825	COG1272	protein, Hemolysin III
M6D76_08830	COG3422	double-strand break repair
M6D76_08855	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M6D76_08860	COG0765	amino acid transport
M6D76_08865	COG0765	amino acid transport
M6D76_08870	COG1126	abc transporter atp-binding protein
M6D76_08920	COG2871	sodium ion transport
M6D76_08950	COG2814	Major facilitator Superfamily
M6D76_08955	COG1280	lysine exporter protein (LysE YggA)
M6D76_08960	COG1609	Transcriptional regulator
M6D76_08970	COG0402	S-adenosylhomocysteine deaminase activity
M6D76_08995	COG0330	HflC and HflK could
M6D76_09000	COG1585	Membrane protein implicated in regulation of membrane protease activity
M6D76_09005	COG2226	methyltransferase
M6D76_09015	COG3042	response to heat
M6D76_09040	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
M6D76_09045	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
M6D76_09060	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
M6D76_09065	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
M6D76_09095	COG0291	Belongs to the bacterial ribosomal protein bL35 family
M6D76_09100	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
M6D76_09105	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
M6D76_09110	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M6D76_09110	COG0072	phenylalanine-tRNA ligase activity
M6D76_09125	COG2833	Protein of unknown function (DUF455)
M6D76_09140	COG5265	(ABC) transporter
M6D76_09145	COG1959	2 iron, 2 sulfur cluster binding
M6D76_09150	COG0719	Fe-S assembly protein
M6D76_09155	COG0396	ATPase activity
M6D76_09160	COG0719	Fe-S assembly protein
M6D76_09170	COG0822	iron-sulfur transferase activity
M6D76_09175	COG2151	metal-sulfur cluster biosynthetic enzyme
M6D76_09195	COG1538	Outer membrane efflux protein
M6D76_09215	COG2274	protein secretion by the type I secretion system
M6D76_09225	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
M6D76_09225	COG1181	Belongs to the D-alanine--D-alanine ligase family
M6D76_09255	COG0747	negative chemotaxis
M6D76_09260	COG0601	transmembrane transport
M6D76_09265	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M6D76_09270	COG4172	Belongs to the ABC transporter superfamily
M6D76_09280	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
M6D76_09335	COG0604	alcohol dehydrogenase
M6D76_09340	COG2207	Transcriptional regulator
M6D76_09345	COG3048	D-serine ammonia-lyase activity
M6D76_09350	COG3258	Cytochrome c
M6D76_09365	COG3949	Membrane
M6D76_09375	COG1262	PFAM Formylglycine-generating sulfatase enzyme
M6D76_09390	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
M6D76_09395	COG0569	domain protein
M6D76_09400	COG1902	pentaerythritol trinitrate reductase activity
M6D76_09410	COG1610	YqeY-like protein
M6D76_09415	COG0587	DNA-directed DNA polymerase activity
M6D76_09455	COG0583	DNA-binding transcription factor activity
M6D76_09460	COG1686	Belongs to the peptidase S11 family
M6D76_09475	COG1360	Flagellar Motor Protein
M6D76_09485	COG1028	Short-chain dehydrogenase reductase Sdr
M6D76_09490	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M6D76_09495	COG4221	oxidoreductase activity
M6D76_09505	COG0307	riboflavin synthase, alpha
M6D76_09520	COG1301	dicarboxylic acid transport
M6D76_09525	COG4191	Histidine kinase
M6D76_09535	COG0583	DNA-binding transcription factor activity
M6D76_09540	COG1053	succinate dehydrogenase
M6D76_09590	COG2233	PERMEase
M6D76_09595	COG0071	Belongs to the small heat shock protein (HSP20) family
M6D76_09600	COG1473	amidohydrolase
M6D76_09610	COG2814	Major facilitator Superfamily
M6D76_09640	COG2816	NAD+ diphosphatase activity
M6D76_09645	COG1561	YicC-like family, N-terminal region
M6D76_09660	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
M6D76_09665	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
M6D76_09670	COG0635	Involved in the biosynthesis of porphyrin-containing compound
M6D76_09675	COG0174	glutamine synthetase
M6D76_09680	COG2153	protein acetylation
M6D76_09700	COG3842	ATPase activity
M6D76_09705	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
M6D76_09710	COG1840	ABC-type Fe3 transport system, periplasmic component
M6D76_09725	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
M6D76_09735	COG0783	Belongs to the Dps family
M6D76_09745	COG3842	ATPase activity
M6D76_09750	COG0395	ABC-type sugar transport system, permease component
M6D76_09755	COG1175	transmembrane transport
M6D76_09760	COG1653	transport
M6D76_09775	COG0559	Belongs to the binding-protein-dependent transport system permease family
M6D76_09795	COG0625	glutathione transferase activity
M6D76_09805	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
M6D76_09810	COG1028	Short-chain dehydrogenase reductase Sdr
M6D76_09820	COG0114	fumarate hydratase activity
M6D76_09825	COG2133	pyrroloquinoline quinone binding
M6D76_09830	COG2226	methyltransferase
M6D76_09835	COG0589	response to stress
M6D76_09840	COG4654	Cytochrome c, class I
M6D76_09845	COG2207	Transcriptional regulator
M6D76_09850	COG0235	Class ii aldolase
M6D76_09860	COG1012	belongs to the aldehyde dehydrogenase family
M6D76_09865	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M6D76_09870	COG2807	transmembrane transport
M6D76_09880	COG0583	DNA-binding transcription factor activity
M6D76_09915	COG0583	DNA-binding transcription factor activity
M6D76_09920	COG4974	Belongs to the 'phage' integrase family
M6D76_09930	COG2132	Multicopper oxidase
M6D76_09935	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
M6D76_10070	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
M6D76_10115	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
M6D76_10150	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
M6D76_10155	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
M6D76_10205	COG0183	Belongs to the thiolase family
M6D76_10215	COG0667	Aldo Keto reductase
M6D76_10220	COG0183	Belongs to the thiolase family
M6D76_10235	COG2003	Belongs to the UPF0758 family
M6D76_10325	COG2894	cell division
M6D76_10330	COG1028	Short-chain dehydrogenase reductase Sdr
M6D76_10375	COG3038	cytochrome b561
M6D76_10385	COG2353	YceI-like domain
M6D76_10390	COG1393	Belongs to the ArsC family
M6D76_10395	COG0625	glutathione transferase activity
M6D76_10420	COG0084	hydrolase, TatD family'
M6D76_10425	COG0470	DNA polymerase III
M6D76_10435	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
M6D76_10440	COG0354	folic acid binding
M6D76_10455	COG1960	acyl-CoA dehydrogenase activity
M6D76_10460	COG2914	Belongs to the UPF0125 (RnfH) family
M6D76_10465	COG2867	negative regulation of translational initiation
M6D76_10470	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
M6D76_10475	COG1252	NADH dehydrogenase
M6D76_10500	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
M6D76_10505	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
M6D76_10510	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
M6D76_10520	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
M6D76_10525	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
M6D76_10535	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
M6D76_10545	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
M6D76_10550	COG0575	Belongs to the CDS family
M6D76_10555	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
M6D76_10560	COG0233	cytoplasmic translational termination
M6D76_10565	COG0528	UMP kinase activity
M6D76_10570	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
M6D76_10575	COG0052	Belongs to the universal ribosomal protein uS2 family
M6D76_10580	COG0024	Methionine aminopeptidase
M6D76_10585	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
M6D76_10610	COG1286	toxin biosynthetic process
M6D76_10620	COG0285	dihydrofolate synthase activity
M6D76_10625	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M6D76_10630	COG0508	dehydrogenase complex catalyzes the overall conversion of
M6D76_10635	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
M6D76_10650	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
M6D76_10660	COG1999	signal sequence binding
M6D76_10665	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
M6D76_10670	COG0640	Transcriptional regulator
M6D76_10685	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
M6D76_10690	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
M6D76_10695	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
M6D76_10700	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
M6D76_10705	COG1028	Short-chain dehydrogenase reductase Sdr
M6D76_10710	COG1028	Short-chain dehydrogenase reductase Sdr
M6D76_10730	COG0183	Belongs to the thiolase family
M6D76_10750	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
M6D76_10760	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
M6D76_10765	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M6D76_10770	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
M6D76_10790	COG0183	Belongs to the thiolase family
M6D76_10795	COG0183	Belongs to the thiolase family
M6D76_10805	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
M6D76_10815	COG0583	DNA-binding transcription factor activity
M6D76_10840	COG0194	GDP metabolic process
M6D76_10845	COG1758	RNA polymerase activity
M6D76_10850	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
M6D76_10855	COG0583	DNA-binding transcription factor activity
M6D76_10860	COG0583	DNA-binding transcription factor activity
M6D76_10865	COG0179	Fumarylacetoacetate (FAA) hydrolase
M6D76_10885	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
M6D76_10890	COG0739	heme binding
M6D76_10895	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
M6D76_10900	COG0584	glycerophosphoryl diester phosphodiesterase
M6D76_10905	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
M6D76_10910	COG1187	pseudouridine synthase activity
M6D76_10915	COG3161	chorismate lyase activity
M6D76_10920	COG2814	Major facilitator Superfamily
M6D76_10925	COG0656	L-ascorbic acid biosynthetic process
M6D76_10935	COG0668	transmembrane transport
M6D76_10940	COG0165	Argininosuccinate lyase
M6D76_10945	COG0789	Transcriptional regulator
M6D76_10950	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
M6D76_10975	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
M6D76_10985	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
M6D76_10990	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
M6D76_10995	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
M6D76_11000	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
M6D76_11005	COG2252	PERMEase
M6D76_11010	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M6D76_11030	COG0488	(ABC) transporter
M6D76_11035	COG1619	proteins homologs of microcin C7 resistance protein MccF
M6D76_11040	COG0590	tRNA wobble adenosine to inosine editing
M6D76_11045	COG1131	(ABC) transporter
M6D76_11050	COG0842	Transport permease protein
M6D76_11060	COG1666	GTP binding
M6D76_11065	COG0318	PFAM AMP-dependent synthetase and ligase
M6D76_11070	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
M6D76_11075	COG0519	Catalyzes the synthesis of GMP from XMP
M6D76_11075	COG0518	GMP synthase (glutamine-hydrolyzing) activity
M6D76_11080	COG2207	Transcriptional regulator
M6D76_11095	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M6D76_11100	COG0135	phosphoribosylanthranilate isomerase activity
M6D76_11105	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
M6D76_11115	COG0101	tRNA pseudouridine synthase activity
M6D76_11125	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
M6D76_11130	COG0473	3-isopropylmalate dehydrogenase activity
M6D76_11150	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
M6D76_11155	COG0625	glutathione transferase activity
M6D76_11160	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
M6D76_11175	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
M6D76_11180	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
M6D76_11190	COG1295	ribonuclease BN
M6D76_11200	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
M6D76_11210	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
M6D76_11220	COG1538	Outer membrane efflux protein
M6D76_11225	COG1136	(ABC) transporter
M6D76_11225	COG0577	efflux transmembrane transporter activity
M6D76_11230	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M6D76_11275	COG4964	Belongs to the GSP D family
M6D76_11320	COG2959	enzyme of heme biosynthesis
M6D76_11330	COG0181	hydroxymethylbilane synthase activity
M6D76_11335	COG0861	Integral membrane protein TerC family
M6D76_11340	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
M6D76_11345	COG0045	succinate-CoA ligase (ADP-forming) activity
M6D76_11355	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
M6D76_11360	COG0583	DNA-binding transcription factor activity
M6D76_11365	COG2137	regulation of response to DNA damage stimulus
M6D76_11370	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
M6D76_11385	COG0477	Major facilitator Superfamily
M6D76_11400	COG0318	PFAM AMP-dependent synthetase and ligase
M6D76_11405	COG1024	Enoyl-CoA hydratase
M6D76_11410	COG3162	membrane
M6D76_11425	COG0540	Belongs to the ATCase OTCase family
M6D76_11440	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
M6D76_11455	COG2070	2-Nitropropane dioxygenase
M6D76_11465	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
M6D76_11465	COG2111	Na H antiporter
M6D76_11470	COG1006	Multisubunit Na H antiporter MnhC subunit
M6D76_11475	COG0651	ATP synthesis coupled electron transport
M6D76_11485	COG2212	antiporter activity
M6D76_11500	COG3158	transport of potassium into the cell
M6D76_11505	COG0642	Histidine kinase
M6D76_11530	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
M6D76_11535	COG4208	sulfate ABC transporter
M6D76_11540	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
M6D76_11545	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
M6D76_11565	COG1278	Cold shock
M6D76_11580	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
M6D76_11580	COG1648	precorrin-2 dehydrogenase activity
M6D76_11595	COG1522	sequence-specific DNA binding
M6D76_11610	COG0535	radical SAM domain protein
M6D76_11615	COG1648	precorrin-2 dehydrogenase activity
M6D76_11615	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
M6D76_11625	COG2010	Cytochrome c
M6D76_11630	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M6D76_11635	COG0626	cystathionine gamma-synthase activity
M6D76_11640	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
M6D76_11645	COG0557	exoribonuclease II activity
M6D76_11680	COG0765	amino acid transport
M6D76_11685	COG0765	amino acid transport
M6D76_11690	COG1126	abc transporter atp-binding protein
M6D76_11705	COG1850	ribulose-bisphosphate carboxylase activity
M6D76_11725	COG2375	cellular response to nickel ion
M6D76_11755	COG0583	DNA-binding transcription factor activity
M6D76_11760	COG3842	ATPase activity
M6D76_11765	COG1177	transmembrane transport
M6D76_11770	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
M6D76_11775	COG1840	ABC-type Fe3 transport system, periplasmic component
M6D76_11795	COG0412	Dienelactone hydrolase
M6D76_11800	COG3530	Putative quorum-sensing-regulated virulence factor
M6D76_11805	COG0625	glutathione transferase activity
M6D76_11815	COG1741	Belongs to the pirin family
M6D76_11825	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
M6D76_11830	COG2814	Major facilitator Superfamily
M6D76_11835	COG2807	transmembrane transport
M6D76_11840	COG2207	Transcriptional regulator
M6D76_11845	COG3135	benzoate transporter
M6D76_11870	COG1529	Aldehyde oxidase and xanthine dehydrogenase
M6D76_11880	COG0402	S-adenosylhomocysteine deaminase activity
M6D76_11890	COG0745	RESPONSE REGULATOR receiver
M6D76_11895	COG2205	protein histidine kinase activity
M6D76_11910	COG0828	Belongs to the bacterial ribosomal protein bS21 family
M6D76_11915	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
M6D76_11920	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
M6D76_11930	COG0330	HflC and HflK could
M6D76_11935	COG0330	HflC and HflK could
M6D76_11940	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
M6D76_11945	COG1923	regulation of RNA biosynthetic process
M6D76_11955	COG1160	GTP binding
M6D76_11960	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
M6D76_11965	COG2976	Protein conserved in bacteria
M6D76_11985	COG0820	rRNA (adenine-C2-)-methyltransferase activity
M6D76_11990	COG0105	UTP biosynthetic process
M6D76_12000	COG0583	DNA-binding transcription factor activity
M6D76_12005	COG0697	spore germination
M6D76_12010	COG0336	Belongs to the RNA methyltransferase TrmD family
M6D76_12020	COG0228	four-way junction DNA binding
M6D76_12025	COG0425	Belongs to the sulfur carrier protein TusA family
M6D76_12030	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
M6D76_12045	COG2351	hydroxyisourate hydrolase activity
M6D76_12080	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M6D76_12105	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
M6D76_12110	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
M6D76_12135	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M6D76_12140	COG0601	transmembrane transport
M6D76_12170	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
M6D76_12175	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
M6D76_12180	COG0542	response to heat
M6D76_12185	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
M6D76_12200	COG0348	domain, Protein
M6D76_12220	COG3278	Belongs to the heme-copper respiratory oxidase family
M6D76_12230	COG2217	Heavy metal translocating P-type atpase
M6D76_12235	COG2224	Isocitrate lyase
M6D76_12240	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
M6D76_12240	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
M6D76_12260	COG1472	Belongs to the glycosyl hydrolase 3 family
M6D76_12265	COG0736	holo-[acyl-carrier-protein] synthase activity
M6D76_12275	COG2050	protein possibly involved in aromatic compounds catabolism
M6D76_12280	COG1024	Enoyl-CoA hydratase
M6D76_12285	COG1012	belongs to the aldehyde dehydrogenase family
M6D76_12290	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
M6D76_12295	COG2151	metal-sulfur cluster biosynthetic enzyme
M6D76_12300	COG3396	Phenylacetate-CoA oxygenase
M6D76_12305	COG3460	Phenylacetate-CoA oxygenase
M6D76_12310	COG3396	Phenylacetate-CoA oxygenase
M6D76_12315	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
M6D76_12320	COG0501	Belongs to the peptidase M48B family
M6D76_12325	COG1162	GTPase activity
M6D76_12335	COG0335	large ribosomal subunit rRNA binding
M6D76_12355	COG0450	alkyl hydroperoxide reductase
M6D76_12360	COG1960	acyl-CoA dehydrogenase activity
M6D76_12375	COG0123	including yeast histone deacetylase and acetoin utilization protein
M6D76_12380	COG2951	lytic endotransglycosylase activity
M6D76_12395	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M6D76_12400	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
M6D76_12405	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
M6D76_12425	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
M6D76_12430	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
M6D76_12435	COG0287	Prephenate dehydrogenase
M6D76_12445	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
M6D76_12460	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
M6D76_12470	COG0583	DNA-binding transcription factor activity
M6D76_12480	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
M6D76_12490	COG4771	TonB-dependent receptor
M6D76_12505	COG0753	catalase activity
M6D76_12510	COG1408	metallophosphoesterase
M6D76_12515	COG4335	DNA alkylation repair
M6D76_12525	COG0436	Aminotransferase
M6D76_12535	COG0251	oxidation-reduction process
M6D76_12540	COG1309	transcriptional regulator
M6D76_12550	COG0488	(ABC) transporter
M6D76_12600	COG0625	glutathione transferase activity
M6D76_12610	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
M6D76_12615	COG1280	lysine exporter protein (LysE YggA)
M6D76_12635	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
M6D76_12645	COG0784	Response regulator, receiver
M6D76_12645	COG2205	protein histidine kinase activity
M6D76_12645	COG2198	Histidine kinase
M6D76_12650	COG2046	Belongs to the sulfate adenylyltransferase family
M6D76_12655	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
M6D76_12670	COG0840	transmembrane signaling receptor activity
M6D76_12675	COG2119	membrane
M6D76_12690	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
M6D76_12695	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
M6D76_12710	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
M6D76_12715	COG2321	neutral zinc metallopeptidase
M6D76_12725	COG2271	Major facilitator Superfamily
M6D76_12730	COG2175	clavaminate synthase activity
M6D76_12735	COG1846	Transcriptional regulator
M6D76_12740	COG0347	Belongs to the P(II) protein family
M6D76_12745	COG0004	ammonium transporteR
M6D76_12750	COG3909	cytochrome
M6D76_12760	COG0625	glutathione transferase activity
M6D76_12770	COG0657	acetylesterase activity
M6D76_12775	COG0730	response to heat
M6D76_12780	COG0482	sulfurtransferase activity
M6D76_12785	COG0277	FAD linked oxidase domain protein
M6D76_12790	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
M6D76_12795	COG2879	small protein
M6D76_12800	COG1966	Carbon starvation protein
M6D76_12805	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M6D76_12810	COG0765	amino acid transport
M6D76_12815	COG0765	amino acid transport
M6D76_12820	COG1126	abc transporter atp-binding protein
M6D76_12835	COG5285	phytanoyl-CoA dioxygenase
M6D76_12840	COG0662	Cupin 2, conserved barrel domain protein
M6D76_12850	COG0456	acetyltransferase
M6D76_12855	COG1846	Transcriptional regulator
M6D76_12865	COG0312	modulator of DNA gyrase
M6D76_12880	COG0308	aminopeptidase N
M6D76_12885	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
M6D76_12900	COG0473	3-isopropylmalate dehydrogenase activity
M6D76_12910	COG0433	COG0433 Predicted ATPase
M6D76_12915	COG0217	transcriptional regulatory protein
M6D76_12920	COG0151	Belongs to the GarS family
M6D76_12930	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
M6D76_12935	COG0799	negative regulation of ribosome biogenesis
M6D76_12940	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
M6D76_12945	COG0424	maF-like protein
M6D76_12965	COG0023	Translation Initiation Factor
M6D76_12975	COG2084	Dehydrogenase
M6D76_12980	COG0625	glutathione transferase activity
M6D76_12985	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
M6D76_12990	COG1047	Peptidyl-prolyl cis-trans
M6D76_12995	COG2003	Belongs to the UPF0758 family
M6D76_13000	COG1737	Transcriptional regulator
M6D76_13005	COG0477	Major facilitator Superfamily
M6D76_13015	COG2271	Major facilitator Superfamily
M6D76_13030	COG0534	Mate efflux family protein
M6D76_13035	COG4175	Glycine betaine
M6D76_13040	COG4176	ABC-type proline glycine betaine transport system permease component
M6D76_13050	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
M6D76_13055	COG2814	Major facilitator Superfamily
M6D76_13060	COG0227	Belongs to the bacterial ribosomal protein bL28 family
M6D76_13065	COG0267	Belongs to the bacterial ribosomal protein bL33 family
M6D76_13070	COG0495	leucyl-tRNA aminoacylation
M6D76_13080	COG1466	dna polymerase III delta subunit
M6D76_13085	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
M6D76_13090	COG1981	membrane
M6D76_13105	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
M6D76_13115	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
M6D76_13120	COG0148	phosphopyruvate hydratase activity
M6D76_13130	COG2814	Major facilitator Superfamily
M6D76_13145	COG2877	3-deoxy-8-phosphooctulonate synthase activity
M6D76_13155	COG0504	CTP synthase activity
M6D76_13190	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
M6D76_13200	COG0791	NLP P60 protein
M6D76_13210	COG0583	DNA-binding transcription factor activity
M6D76_13220	COG0583	DNA-binding transcription factor activity
M6D76_13230	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
M6D76_13245	COG1045	serine acetyltransferase
M6D76_13260	COG1381	Involved in DNA repair and RecF pathway recombination
M6D76_13265	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
M6D76_13270	COG0571	ribonuclease III activity
M6D76_13285	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
M6D76_13310	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
M6D76_13315	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M6D76_13320	COG1028	Short-chain dehydrogenase reductase Sdr
M6D76_13325	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
M6D76_13330	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
M6D76_13340	COG0333	Belongs to the bacterial ribosomal protein bL32 family
M6D76_13345	COG1399	metal-binding, possibly nucleic acid-binding protein
M6D76_13350	COG0424	maF-like protein
M6D76_13360	COG3023	N-Acetylmuramoyl-L-alanine amidase
M6D76_13365	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
M6D76_13370	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
M6D76_13375	COG0546	phosphoglycolate phosphatase activity
M6D76_13380	COG0564	pseudouridine synthase activity
M6D76_13385	COG1530	ribonuclease E activity
M6D76_13390	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
M6D76_13395	COG0159	tryptophan synthase activity
M6D76_13400	COG0133	tryptophan synthase activity
M6D76_13405	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
M6D76_13415	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
M6D76_13420	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
M6D76_13430	COG2878	Part of a membrane complex involved in electron transport
M6D76_13435	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
M6D76_13440	COG1129	ABC transporter
M6D76_13445	COG3047	cAMP biosynthetic process
M6D76_13470	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
M6D76_13475	COG2917	probably involved in intracellular septation
M6D76_13485	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
M6D76_13490	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
M6D76_13500	COG1196	nuclear chromosome segregation
M6D76_13510	COG1573	uracil-dna glycosylase
M6D76_13515	COG1214	PFAM Peptidase M22, glycoprotease
M6D76_13530	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
M6D76_13535	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
M6D76_13540	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
M6D76_13545	COG0560	Phosphoserine phosphatase
M6D76_13550	COG2070	2-Nitropropane dioxygenase
M6D76_13560	COG1007	ATP synthesis coupled electron transport
M6D76_13575	COG0713	ATP synthesis coupled electron transport
M6D76_13585	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
M6D76_13590	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
M6D76_13595	COG1034	ATP synthesis coupled electron transport
M6D76_13610	COG0649	NAD binding
M6D76_13615	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
M6D76_13620	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
M6D76_13625	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
M6D76_13630	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
M6D76_13645	COG0149	triose-phosphate isomerase activity
M6D76_13650	COG0604	alcohol dehydrogenase
M6D76_13670	COG1185	polyribonucleotide nucleotidyltransferase activity
M6D76_13675	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
M6D76_13680	COG1183	phosphatidylcholine synthase activity
M6D76_13685	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
M6D76_13690	COG0440	acetolactate synthase activity
M6D76_13695	COG0028	Belongs to the TPP enzyme family
M6D76_13700	COG1289	transmembrane transporter activity
M6D76_13705	COG3022	response to hydroperoxide
M6D76_13710	COG1028	Short-chain dehydrogenase reductase Sdr
M6D76_13730	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
M6D76_13735	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
M6D76_13740	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
M6D76_13745	COG1674	ftsk spoiiie
M6D76_13750	COG0492	ferredoxin-NADP+ reductase activity
M6D76_13770	COG0477	Major facilitator Superfamily
M6D76_13790	COG2272	Belongs to the type-B carboxylesterase lipase family
M6D76_13795	COG1960	acyl-CoA dehydrogenase activity
M6D76_13820	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
M6D76_13840	COG2204	response regulator
M6D76_13880	COG4964	Belongs to the GSP D family
M6D76_13940	COG0612	Peptidase, M16
M6D76_13945	COG0484	heat shock protein binding
M6D76_13950	COG0443	Heat shock 70 kDa protein
M6D76_13955	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
M6D76_13960	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
M6D76_13965	COG1420	regulation of RNA biosynthetic process
M6D76_13975	COG0497	DNA recombination
M6D76_13980	COG0735	belongs to the Fur family
M6D76_13985	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
M6D76_13990	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
M6D76_14005	COG2267	carboxylic ester hydrolase activity
M6D76_14015	COG0477	Major facilitator Superfamily
M6D76_14020	COG1301	dicarboxylic acid transport
M6D76_14030	COG0812	UDP-N-acetylmuramate dehydrogenase activity
M6D76_14055	COG1538	Outer membrane efflux protein
M6D76_14080	COG2814	Major facilitator Superfamily
M6D76_14100	COG2814	Major facilitator Superfamily
M6D76_14110	COG0243	molybdopterin cofactor binding
M6D76_14110	COG3383	formate dehydrogenase (NAD+) activity
M6D76_14115	COG0437	4 iron, 4 sulfur cluster binding
M6D76_14120	COG2864	formate dehydrogenase
M6D76_14125	COG3058	Necessary for formate dehydrogenase activity
M6D76_14130	COG2819	hydrolase of the alpha beta superfamily
M6D76_14150	COG1454	alcohol dehydrogenase
M6D76_14185	COG1414	Transcriptional regulator
M6D76_14190	COG0513	Belongs to the DEAD box helicase family
M6D76_14200	COG0583	DNA-binding transcription factor activity
M6D76_14205	COG4638	Rieske (2fe-2S)
M6D76_14210	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
M6D76_14225	COG0446	pyridine nucleotide-disulphide oxidoreductase
M6D76_14240	COG3971	2-oxopent-4-enoate hydratase activity
M6D76_14245	COG4569	acetaldehyde dehydrogenase (acetylating) activity
M6D76_14255	COG2814	Major facilitator Superfamily
M6D76_14275	COG3121	Chaperone
M6D76_14285	COG0784	Response regulator, receiver
M6D76_14285	COG2205	protein histidine kinase activity
M6D76_14290	COG0784	Response regulator, receiver
M6D76_14290	COG2205	protein histidine kinase activity
M6D76_14295	COG2197	response regulator
M6D76_14315	COG0154	amidase activity
M6D76_14320	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M6D76_14325	COG2814	Major facilitator Superfamily
M6D76_14360	COG1028	Short-chain dehydrogenase reductase Sdr
M6D76_14370	COG0842	Transport permease protein
M6D76_14375	COG1129	ABC transporter
M6D76_14375	COG0842	Transport permease protein
M6D76_14380	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M6D76_14385	COG1538	Outer membrane efflux protein
M6D76_14390	COG3243	poly(R)-hydroxyalkanoic acid synthase
M6D76_14400	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
M6D76_14405	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
M6D76_14415	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
M6D76_14430	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
M6D76_14445	COG0505	Belongs to the CarA family
M6D76_14450	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
M6D76_14460	COG0789	Transcriptional regulator
M6D76_14470	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
M6D76_14515	COG3278	Belongs to the heme-copper respiratory oxidase family
M6D76_14520	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M6D76_14540	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
M6D76_14590	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
M6D76_14655	COG0516	GMP reductase activity
M6D76_14655	COG0517	IMP dehydrogenase activity
M6D76_14670	COG1027	Aspartate ammonia-lyase
M6D76_14675	COG1846	Transcriptional regulator
M6D76_14690	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
M6D76_14695	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
M6D76_14710	COG1414	Transcriptional regulator
M6D76_14730	COG0513	Belongs to the DEAD box helicase family
M6D76_14750	COG0429	hydrolase of the alpha beta-hydrolase fold
M6D76_14775	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M6D76_14785	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
M6D76_14795	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
M6D76_14800	COG0632	four-way junction helicase activity
M6D76_14810	COG2255	four-way junction helicase activity
M6D76_14820	COG0418	dihydroorotase activity
M6D76_14830	COG0415	Belongs to the DNA photolyase family
M6D76_14900	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
M6D76_14905	COG4654	Cytochrome c, class I
M6D76_14945	COG1177	transmembrane transport
M6D76_14950	COG3842	ATPase activity
M6D76_14955	COG1840	ABC-type Fe3 transport system, periplasmic component
M6D76_14960	COG2084	Dehydrogenase
M6D76_14975	COG0494	nUDIX hydrolase
M6D76_14980	COG0442	prolyl-tRNA aminoacylation
M6D76_14985	COG0824	Thioesterase
M6D76_14990	COG0811	peptide transport
M6D76_15005	COG0823	Involved in the tonB-independent uptake of proteins
M6D76_15020	COG0596	Alpha beta hydrolase
M6D76_15045	COG1079	Belongs to the binding-protein-dependent transport system permease family
M6D76_15050	COG4603	Belongs to the binding-protein-dependent transport system permease family
M6D76_15055	COG3845	ABC transporter
M6D76_15075	COG0427	acetyl-CoA hydrolase
M6D76_15080	COG0583	DNA-binding transcription factor activity
M6D76_15085	COG3634	alkyl hydroperoxide reductase activity
M6D76_15100	COG0697	spore germination
M6D76_15105	COG0175	sulfate reduction
M6D76_15115	COG2895	sulfate adenylyltransferase (ATP) activity
M6D76_15120	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
M6D76_15135	COG0583	DNA-binding transcription factor activity
M6D76_15140	COG1741	Belongs to the pirin family
M6D76_15150	COG3706	GGDEF domain
M6D76_15155	COG0154	amidase activity
M6D76_15165	COG3712	iron ion homeostasis
M6D76_15170	COG1595	DNA-templated transcription, initiation
M6D76_15195	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
M6D76_15205	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
M6D76_15210	COG0284	orotidine-5'-phosphate decarboxylase activity
M6D76_15225	COG1414	Transcriptional regulator
M6D76_15235	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
M6D76_15240	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
M6D76_15245	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
M6D76_15250	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
M6D76_15275	COG0742	ribosomal rna small subunit methyltransferase
M6D76_15280	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
M6D76_15285	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
M6D76_15315	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
M6D76_15340	COG1335	isochorismatase
M6D76_15345	COG2309	aminopeptidase activity
M6D76_15350	COG0596	Alpha beta hydrolase
M6D76_15355	COG2010	Cytochrome c
M6D76_15355	COG1529	Aldehyde oxidase and xanthine dehydrogenase
M6D76_15360	COG2080	2 iron, 2 sulfur cluster binding
M6D76_15365	COG2010	Cytochrome c
M6D76_15365	COG1529	Aldehyde oxidase and xanthine dehydrogenase
M6D76_15375	COG0410	ABC transporter
M6D76_15380	COG0411	ABC transporter
M6D76_15405	COG3706	GGDEF domain
M6D76_15420	COG3181	Tripartite tricarboxylate transporter family receptor
M6D76_15440	COG1234	tRNA 3'-trailer cleavage
M6D76_15445	COG2188	Transcriptional regulator
M6D76_15455	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
M6D76_15465	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
M6D76_15465	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
M6D76_15470	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
M6D76_15470	COG3608	succinylglutamate desuccinylase aspartoacylase
M6D76_15475	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
M6D76_15485	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
M6D76_15490	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
M6D76_15515	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
M6D76_15540	COG1335	isochorismatase
M6D76_15545	COG2309	aminopeptidase activity
M6D76_15550	COG0596	Alpha beta hydrolase
M6D76_15565	COG1120	ATPase activity
M6D76_15570	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M6D76_15580	COG4206	TonB-dependent receptor
M6D76_15585	COG2031	fatty acid transporter
M6D76_15600	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
M6D76_15605	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M6D76_15610	COG0328	RNA-DNA hybrid ribonuclease activity
M6D76_15615	COG2226	methyltransferase
M6D76_15620	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M6D76_15625	COG0741	lytic transglycosylase activity
M6D76_15625	COG1388	LysM domain
M6D76_15645	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
M6D76_15670	COG2204	response regulator
M6D76_15675	COG4191	Histidine kinase
M6D76_15680	COG1301	dicarboxylic acid transport
M6D76_15690	COG1054	Belongs to the UPF0176 family
M6D76_15715	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
M6D76_15735	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
M6D76_15750	COG1028	Short-chain dehydrogenase reductase Sdr
M6D76_15755	COG1877	trehalose-phosphatase activity
M6D76_15790	COG0604	alcohol dehydrogenase
M6D76_15800	COG1024	Enoyl-CoA hydratase
M6D76_15820	COG2015	COG2015, Alkyl sulfatase and related hydrolases
M6D76_15845	COG1280	lysine exporter protein (LysE YggA)
M6D76_15855	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M6D76_15870	COG1393	Belongs to the ArsC family
M6D76_15875	COG0431	NADPH-dependent FMN reductase
M6D76_15880	COG0745	RESPONSE REGULATOR receiver
M6D76_15885	COG0642	Histidine kinase
M6D76_15895	COG1917	Cupin 2, conserved barrel domain protein
M6D76_15895	COG2207	Transcriptional regulator
M6D76_15920	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
M6D76_15920	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
M6D76_15925	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
M6D76_15930	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
M6D76_15935	COG1881	PFAM PEBP family protein
M6D76_15940	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
M6D76_15945	COG0739	heme binding
M6D76_15950	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
M6D76_15955	COG0316	Belongs to the HesB IscA family
M6D76_15965	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
M6D76_15970	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
M6D76_15975	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
M6D76_15980	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
M6D76_15985	COG0312	modulator of DNA gyrase
M6D76_15990	COG3028	Belongs to the UPF0307 family
M6D76_16020	COG2205	protein histidine kinase activity
M6D76_16020	COG4191	Histidine kinase
M6D76_16020	COG0745	RESPONSE REGULATOR receiver
M6D76_16025	COG4566	intracellular signal transduction
M6D76_16030	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
M6D76_16060	COG0762	integral membrane protein
M6D76_16075	COG3133	Outer membrane lipoprotein
M6D76_16080	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M6D76_16095	COG0439	Biotin carboxylase
M6D76_16100	COG0511	ligase activity, forming carbon-carbon bonds
M6D76_16105	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
M6D76_16110	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M6D76_16115	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
M6D76_16120	COG3150	esterase
M6D76_16135	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
M6D76_16140	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
M6D76_16150	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
M6D76_16165	COG1678	Uncharacterized ACR, COG1678
M6D76_16180	COG0352	thiamine-phosphate diphosphorylase activity
M6D76_16185	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
M6D76_16200	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
M6D76_16210	COG3237	CsbD-like
M6D76_16215	COG0261	This protein binds to 23S rRNA in the presence of protein L20
M6D76_16220	COG0211	Belongs to the bacterial ribosomal protein bL27 family
M6D76_16225	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
M6D76_16230	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
M6D76_16255	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
M6D76_16275	COG1126	abc transporter atp-binding protein
M6D76_16280	COG0765	amino acid transport
M6D76_16285	COG4597	amino acid ABC transporter
M6D76_16290	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M6D76_16295	COG2884	Cell division ATP-binding protein ftsE
M6D76_16300	COG2177	Part of the ABC transporter FtsEX involved in
M6D76_16310	COG0772	Belongs to the SEDS family
M6D76_16315	COG0768	penicillin binding
M6D76_16325	COG1792	Involved in formation and maintenance of cell shape
M6D76_16330	COG1077	Cell shape determining protein MreB Mrl
M6D76_16335	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
M6D76_16340	COG0154	amidase activity
M6D76_16345	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
M6D76_16350	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
M6D76_16355	COG0583	DNA-binding transcription factor activity
M6D76_16360	COG2259	Doxx family
M6D76_16365	COG3384	dioxygenase
M6D76_16390	COG3604	Transcriptional regulator
M6D76_16405	COG0786	glutamate:sodium symporter activity
M6D76_16410	COG0142	geranyltranstransferase activity
M6D76_16420	COG0494	nUDIX hydrolase
M6D76_16425	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
M6D76_16450	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
M6D76_16455	COG0237	dephospho-CoA kinase activity
M6D76_16470	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
M6D76_16475	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
M6D76_16485	COG0477	Major facilitator Superfamily
M6D76_16500	COG4206	TonB-dependent receptor
M6D76_16505	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
M6D76_16520	COG1595	DNA-templated transcription, initiation
M6D76_16535	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
M6D76_16555	COG0598	Magnesium transport protein CorA
M6D76_16570	COG2022	thiamine diphosphate biosynthetic process
M6D76_16575	COG0351	phosphomethylpyrimidine kinase
M6D76_16580	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
M6D76_16585	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
M6D76_16590	COG1538	Outer membrane efflux protein
M6D76_16595	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
M6D76_16605	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
M6D76_16620	COG2226	methyltransferase
M6D76_16625	COG0745	RESPONSE REGULATOR receiver
M6D76_16640	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
M6D76_16645	COG1984	allophanate hydrolase subunit 2
M6D76_16650	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
M6D76_16655	COG1238	metal cluster binding
M6D76_16685	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
M6D76_16690	COG4988	ABC transporter
M6D76_16700	COG1294	oxidase, subunit
M6D76_16705	COG1271	oxidase subunit
M6D76_16720	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
M6D76_16735	COG1137	ATPase activity
M6D76_16745	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
M6D76_16750	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
M6D76_16755	COG1660	Displays ATPase and GTPase activities
M6D76_16760	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
M6D76_16765	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
M6D76_16770	COG0792	nuclease activity
M6D76_16775	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
M6D76_16790	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
M6D76_16810	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
M6D76_16815	COG0793	Belongs to the peptidase S41A family
M6D76_16825	COG0588	phosphoglycerate mutase activity
M6D76_16830	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
M6D76_16840	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
M6D76_16845	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
M6D76_16850	COG3181	Tripartite tricarboxylate transporter family receptor
M6D76_16855	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
M6D76_16860	COG1040	competence protein
M6D76_16865	COG2226	methyltransferase
M6D76_16870	COG4771	TonB-dependent receptor
M6D76_16875	COG0745	RESPONSE REGULATOR receiver
M6D76_16890	COG2204	response regulator
M6D76_16905	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
M6D76_16905	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
M6D76_16910	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
M6D76_16920	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
M6D76_16925	COG3473	Maleate cis-trans isomerase
M6D76_16940	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
M6D76_16955	COG0463	Glycosyl transferase, family 2
M6D76_16960	COG0438	transferase activity, transferring glycosyl groups
M6D76_16970	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
M6D76_17015	COG0355	proton-transporting ATP synthase activity, rotational mechanism
M6D76_17025	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
M6D76_17030	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
M6D76_17035	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
M6D76_17050	COG0356	it plays a direct role in the translocation of protons across the membrane
M6D76_17060	COG1024	Enoyl-CoA hydratase
M6D76_17075	COG0037	tRNA processing
M6D76_17080	COG0163	prenyltransferase activity
M6D76_17085	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
M6D76_17090	COG2890	protein-(glutamine-N5) methyltransferase activity
M6D76_17110	COG3550	peptidyl-serine autophosphorylation
M6D76_17150	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
M6D76_17180	COG0811	peptide transport
M6D76_17195	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
M6D76_17200	COG2264	protein methyltransferase activity
M6D76_17225	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
M6D76_17250	COG3180	Ammonia monooxygenase
M6D76_17270	COG5002	protein histidine kinase activity
M6D76_17285	COG0477	Major facilitator Superfamily
M6D76_17290	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
M6D76_17310	COG1116	anion transmembrane transporter activity
M6D76_17340	COG0437	4 iron, 4 sulfur cluster binding
M6D76_17345	COG2864	formate dehydrogenase
M6D76_17355	COG1921	L-seryl-tRNASec selenium transferase activity
M6D76_17360	COG3276	selenocysteine insertion sequence binding
M6D76_17385	COG0709	Synthesizes selenophosphate from selenide and ATP
M6D76_17390	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
M6D76_17395	COG0348	domain, Protein
M6D76_17395	COG3901	Regulator of nitric oxide reductase transcription
M6D76_17400	COG4263	nitrous-oxide reductase activity
M6D76_17415	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
M6D76_17430	COG0166	Belongs to the GPI family
M6D76_17455	COG1215	transferase activity, transferring glycosyl groups
M6D76_17480	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
M6D76_17515	COG0156	8-amino-7-oxononanoate synthase activity
M6D76_17520	COG0604	alcohol dehydrogenase
M6D76_17520	COG1028	Short-chain dehydrogenase reductase Sdr
M6D76_17520	COG3321	synthase
M6D76_17525	COG2233	PERMEase
M6D76_17530	COG0697	spore germination
M6D76_17535	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M6D76_17540	COG0697	spore germination
M6D76_17560	COG2885	chlorophyll binding
M6D76_17655	COG0183	Belongs to the thiolase family
M6D76_17660	COG1024	Enoyl-CoA hydratase
M6D76_17660	COG1250	3-hydroxyacyl-CoA dehydrogenase
M6D76_17675	COG1127	ABC transporter
M6D76_17680	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
M6D76_17685	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
M6D76_17700	COG1131	(ABC) transporter
M6D76_17705	COG0842	Transport permease protein
M6D76_17715	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
M6D76_17725	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
M6D76_17730	COG0131	Imidazoleglycerol-phosphate dehydratase
M6D76_17740	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
M6D76_17745	COG0107	imidazoleglycerol-phosphate synthase activity
M6D76_17755	COG0140	phosphoribosyl-ATP diphosphatase activity
M6D76_17760	COG0537	adenosine 5'-monophosphoramidase activity
M6D76_17765	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
M6D76_17770	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
M6D76_17780	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
M6D76_17790	COG1970	mechanosensitive ion channel activity
M6D76_17795	COG0723	plastoquinol--plastocyanin reductase activity
M6D76_17800	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
M6D76_17805	COG2857	Cytochrome c1
M6D76_17810	COG0625	glutathione transferase activity
M6D76_17815	COG2969	positive regulation of protein catabolic process
M6D76_17820	COG4208	sulfate ABC transporter
M6D76_17825	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
M6D76_17830	COG4150	thiosulfate binding
M6D76_17850	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
M6D76_17870	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
M6D76_17875	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M6D76_17890	COG0129	dihydroxy-acid dehydratase activity
M6D76_17895	COG1802	Transcriptional regulator
M6D76_17900	COG1522	sequence-specific DNA binding
M6D76_17910	COG3483	tryptophan 2,3-dioxygenase activity
M6D76_17930	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
M6D76_17935	COG0656	L-ascorbic acid biosynthetic process
M6D76_17945	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
M6D76_17950	COG3706	GGDEF domain
M6D76_17955	COG2226	methyltransferase
M6D76_17980	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
M6D76_17985	COG0583	DNA-binding transcription factor activity
M6D76_17990	COG0477	Major facilitator Superfamily
M6D76_17995	COG1028	Short-chain dehydrogenase reductase Sdr
M6D76_18005	COG1335	isochorismatase
M6D76_18010	COG1335	isochorismatase
M6D76_18030	COG2823	Periplasmic or secreted lipoprotein
M6D76_18040	COG3284	Transcriptional regulator
M6D76_18055	COG4774	siderophore transport
M6D76_18085	COG1595	DNA-templated transcription, initiation
M6D76_18095	COG1522	sequence-specific DNA binding
M6D76_18105	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
M6D76_18125	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
M6D76_18165	COG0109	protoheme IX farnesyltransferase activity
M6D76_18185	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
M6D76_18205	COG3568	Endonuclease Exonuclease Phosphatase
M6D76_18210	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
M6D76_18235	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M6D76_18245	COG1228	amidohydrolase
M6D76_18265	COG2986	histidine ammonia-lyase
M6D76_18270	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
M6D76_18290	COG0477	Major facilitator Superfamily
M6D76_18295	COG0583	DNA-binding transcription factor activity
M6D76_18305	COG0789	Transcriptional regulator
M6D76_18335	COG0625	glutathione transferase activity
M6D76_18345	COG1017	nitric oxide dioxygenase activity
M6D76_18345	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
M6D76_18365	COG2365	Tyrosine phosphatase family
M6D76_18370	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
M6D76_18390	COG2423	ornithine cyclodeaminase activity
M6D76_18440	COG3069	C4-dicarboxylate transmembrane transporter activity
M6D76_18450	COG1802	Transcriptional regulator
M6D76_18460	COG2814	Major facilitator Superfamily
M6D76_18475	COG2814	Major facilitator Superfamily
M6D76_18480	COG0251	oxidation-reduction process
M6D76_18485	COG3181	Tripartite tricarboxylate transporter family receptor
M6D76_18490	COG0179	Fumarylacetoacetate (FAA) hydrolase
M6D76_18495	COG2186	Transcriptional regulator
M6D76_18500	COG1595	DNA-templated transcription, initiation
M6D76_18505	COG3712	iron ion homeostasis
M6D76_18520	COG2814	Major facilitator Superfamily
M6D76_18530	COG0232	Belongs to the dGTPase family. Type 2 subfamily
M6D76_18535	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
M6D76_18540	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
M6D76_18560	COG5002	protein histidine kinase activity
M6D76_18560	COG5001	Diguanylate cyclase
M6D76_18570	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
M6D76_18575	COG1333	cytochrome c biogenesis protein
M6D76_18585	COG0218	Necessary for normal cell division and for the maintenance of normal septation
M6D76_18590	COG0113	porphobilinogen synthase activity
M6D76_18595	COG4232	protein-disulfide reductase activity
M6D76_18615	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M6D76_18620	COG0203	ribosomal protein L17
M6D76_18625	COG0202	RNA polymerase activity
M6D76_18630	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
M6D76_18635	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
M6D76_18640	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
M6D76_18645	COG0257	Belongs to the bacterial ribosomal protein bL36 family
M6D76_18655	COG0201	protein transport
M6D76_18660	COG0200	Binds to the 23S rRNA
M6D76_18665	COG1841	ribosomal large subunit assembly
M6D76_18670	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
M6D76_18675	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
M6D76_18680	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
M6D76_18685	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
M6D76_18690	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
M6D76_18695	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
M6D76_18700	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
M6D76_18705	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
M6D76_18745	COG1538	Outer membrane efflux protein
M6D76_18760	COG1960	acyl-CoA dehydrogenase activity
M6D76_18765	COG0183	Belongs to the thiolase family
M6D76_18775	COG2067	long-chain fatty acid transport protein
M6D76_18790	COG0318	PFAM AMP-dependent synthetase and ligase
M6D76_18795	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
M6D76_18800	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
M6D76_18805	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
M6D76_18805	COG1648	precorrin-2 dehydrogenase activity
M6D76_18820	COG1116	anion transmembrane transporter activity
M6D76_18825	COG1960	acyl-CoA dehydrogenase activity
M6D76_18840	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
M6D76_18845	COG0255	Belongs to the universal ribosomal protein uL29 family
M6D76_18850	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
M6D76_18855	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
M6D76_18860	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
M6D76_18865	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
M6D76_18870	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
M6D76_18875	COG0089	rRNA binding
M6D76_18880	COG0088	Forms part of the polypeptide exit tunnel
M6D76_18885	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
M6D76_18890	COG4175	Glycine betaine
M6D76_18895	COG4176	ABC-type proline glycine betaine transport system permease component
M6D76_18900	COG0051	transcription antitermination factor activity, RNA binding
M6D76_18905	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
M6D76_18910	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
M6D76_18915	COG0049	tRNA binding
M6D76_18920	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
M6D76_18950	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
M6D76_18955	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
M6D76_18960	COG0085	RNA polymerase activity
M6D76_18965	COG0222	ribosome binding
M6D76_18970	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
M6D76_18975	COG0081	regulation of translation
M6D76_19000	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
M6D76_19020	COG1475	DNA binding
M6D76_19025	COG1192	Involved in chromosome partitioning
M6D76_19030	COG0357	Ribosomal RNA small subunit methyltransferase G
M6D76_19035	COG0445	tRNA wobble uridine modification
M6D76_19040	COG0436	Aminotransferase
M6D76_19050	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
M6D76_19055	COG3706	GGDEF domain
M6D76_19060	COG0688	phosphatidylethanolamine metabolic process
M6D76_19070	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
M6D76_19115	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
M6D76_19150	COG0559	Belongs to the binding-protein-dependent transport system permease family
M6D76_19170	COG0596	Alpha beta hydrolase
M6D76_19175	COG2309	aminopeptidase activity
M6D76_19180	COG1335	isochorismatase
M6D76_19205	COG0753	catalase activity
M6D76_19210	COG0706	membrane insertase activity
M6D76_19215	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
M6D76_19220	COG0594	ribonuclease P activity
M6D76_19225	COG0230	Belongs to the bacterial ribosomal protein bL34 family