locus-tag	class	description
EGY22_00015	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EGY22_00025	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
EGY22_00035	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
EGY22_00040	COG0632	four-way junction helicase activity
EGY22_00050	COG2255	four-way junction helicase activity
EGY22_00060	COG0418	dihydroorotase activity
EGY22_00070	COG0415	Belongs to the DNA photolyase family
EGY22_00130	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EGY22_00135	COG4654	Cytochrome c, class I
EGY22_00175	COG1177	transmembrane transport
EGY22_00180	COG3842	ATPase activity
EGY22_00185	COG1840	ABC-type Fe3 transport system, periplasmic component
EGY22_00190	COG2084	Dehydrogenase
EGY22_00205	COG0494	nUDIX hydrolase
EGY22_00210	COG0442	prolyl-tRNA aminoacylation
EGY22_00215	COG0824	Thioesterase
EGY22_00220	COG0811	peptide transport
EGY22_00235	COG0823	Involved in the tonB-independent uptake of proteins
EGY22_00250	COG0596	Alpha beta hydrolase
EGY22_00265	COG0534	Mate efflux family protein
EGY22_00285	COG1129	ABC transporter
EGY22_00305	COG0427	acetyl-CoA hydrolase
EGY22_00310	COG0583	DNA-binding transcription factor activity
EGY22_00325	COG3634	alkyl hydroperoxide reductase activity
EGY22_00340	COG0697	spore germination
EGY22_00345	COG0175	sulfate reduction
EGY22_00365	COG1012	belongs to the aldehyde dehydrogenase family
EGY22_00370	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EGY22_00375	COG5383	Protein conserved in bacteria
EGY22_00385	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
EGY22_00400	COG0583	DNA-binding transcription factor activity
EGY22_00405	COG1741	Belongs to the pirin family
EGY22_00415	COG3706	GGDEF domain
EGY22_00420	COG0154	amidase activity
EGY22_00435	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
EGY22_00440	COG0459	protein refolding
EGY22_00445	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
EGY22_00450	COG0284	orotidine-5'-phosphate decarboxylase activity
EGY22_00465	COG1414	Transcriptional regulator
EGY22_00475	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
EGY22_00485	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
EGY22_00490	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
EGY22_00515	COG0742	ribosomal rna small subunit methyltransferase
EGY22_00520	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
EGY22_00525	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
EGY22_00555	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
EGY22_00580	COG1335	isochorismatase
EGY22_00585	COG2309	aminopeptidase activity
EGY22_00590	COG0596	Alpha beta hydrolase
EGY22_00595	COG1529	Aldehyde oxidase and xanthine dehydrogenase
EGY22_00595	COG2010	Cytochrome c
EGY22_00600	COG2080	2 iron, 2 sulfur cluster binding
EGY22_00605	COG1529	Aldehyde oxidase and xanthine dehydrogenase
EGY22_00605	COG2010	Cytochrome c
EGY22_00615	COG0410	ABC transporter
EGY22_00620	COG0411	ABC transporter
EGY22_00645	COG3706	GGDEF domain
EGY22_00660	COG3181	Tripartite tricarboxylate transporter family receptor
EGY22_00680	COG1234	tRNA 3'-trailer cleavage
EGY22_00685	COG2188	Transcriptional regulator
EGY22_00695	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EGY22_00705	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
EGY22_00705	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
EGY22_00710	COG3608	succinylglutamate desuccinylase aspartoacylase
EGY22_00710	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
EGY22_00715	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
EGY22_00725	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EGY22_00730	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
EGY22_00755	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
EGY22_00790	COG1335	isochorismatase
EGY22_00795	COG2309	aminopeptidase activity
EGY22_00800	COG0596	Alpha beta hydrolase
EGY22_00815	COG1120	ATPase activity
EGY22_00830	COG4206	TonB-dependent receptor
EGY22_00835	COG2031	fatty acid transporter
EGY22_00840	COG0583	DNA-binding transcription factor activity
EGY22_00845	COG0402	S-adenosylhomocysteine deaminase activity
EGY22_00850	COG3181	Tripartite tricarboxylate transporter family receptor
EGY22_00860	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
EGY22_00865	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EGY22_00870	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EGY22_00875	COG0328	RNA-DNA hybrid ribonuclease activity
EGY22_00880	COG2226	methyltransferase
EGY22_00885	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EGY22_00890	COG0741	lytic transglycosylase activity
EGY22_00890	COG1388	LysM domain
EGY22_00910	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
EGY22_00935	COG2204	response regulator
EGY22_00940	COG4191	Histidine kinase
EGY22_00945	COG1301	dicarboxylic acid transport
EGY22_00980	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
EGY22_01000	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
EGY22_01015	COG1028	Short-chain dehydrogenase reductase Sdr
EGY22_01020	COG1877	trehalose-phosphatase activity
EGY22_01055	COG0604	alcohol dehydrogenase
EGY22_01065	COG1024	Enoyl-CoA hydratase
EGY22_01085	COG2015	COG2015, Alkyl sulfatase and related hydrolases
EGY22_01135	COG1393	Belongs to the ArsC family
EGY22_01140	COG0431	NADPH-dependent FMN reductase
EGY22_01145	COG0745	RESPONSE REGULATOR receiver
EGY22_01150	COG0642	Histidine kinase
EGY22_01165	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EGY22_01165	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EGY22_01170	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
EGY22_01175	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
EGY22_01180	COG1881	PFAM PEBP family protein
EGY22_01185	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
EGY22_01190	COG0739	heme binding
EGY22_01195	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
EGY22_01200	COG0316	Belongs to the HesB IscA family
EGY22_01210	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
EGY22_01215	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
EGY22_01220	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
EGY22_01225	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
EGY22_01230	COG0312	modulator of DNA gyrase
EGY22_01235	COG3028	Belongs to the UPF0307 family
EGY22_01260	COG4566	intracellular signal transduction
EGY22_01265	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
EGY22_01270	COG4681	YaeQ
EGY22_01295	COG0762	integral membrane protein
EGY22_01300	COG2169	Transcriptional regulator
EGY22_01300	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
EGY22_01305	COG3133	Outer membrane lipoprotein
EGY22_01320	COG2264	protein methyltransferase activity
EGY22_01325	COG0439	Biotin carboxylase
EGY22_01330	COG0511	ligase activity, forming carbon-carbon bonds
EGY22_01335	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
EGY22_01340	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EGY22_01345	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
EGY22_01350	COG3150	esterase
EGY22_01365	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
EGY22_01370	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EGY22_01380	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
EGY22_01390	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
EGY22_01395	COG1678	Uncharacterized ACR, COG1678
EGY22_01410	COG0352	thiamine-phosphate diphosphorylase activity
EGY22_01415	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
EGY22_01430	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
EGY22_01440	COG3237	CsbD-like
EGY22_01445	COG0261	This protein binds to 23S rRNA in the presence of protein L20
EGY22_01450	COG0211	Belongs to the bacterial ribosomal protein bL27 family
EGY22_01455	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
EGY22_01460	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
EGY22_01485	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
EGY22_01505	COG1126	abc transporter atp-binding protein
EGY22_01510	COG0765	amino acid transport
EGY22_01515	COG4597	amino acid ABC transporter
EGY22_01520	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EGY22_01525	COG2884	Cell division ATP-binding protein ftsE
EGY22_01530	COG2177	Part of the ABC transporter FtsEX involved in
EGY22_01540	COG0772	Belongs to the SEDS family
EGY22_01545	COG0768	penicillin binding
EGY22_01555	COG1792	Involved in formation and maintenance of cell shape
EGY22_01560	COG1077	Cell shape determining protein MreB Mrl
EGY22_01565	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
EGY22_01570	COG0154	amidase activity
EGY22_01575	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
EGY22_01585	COG0583	DNA-binding transcription factor activity
EGY22_01590	COG2259	Doxx family
EGY22_01595	COG3384	dioxygenase
EGY22_01605	COG3245	cytochrome
EGY22_01620	COG3604	Transcriptional regulator
EGY22_01635	COG0786	glutamate:sodium symporter activity
EGY22_01640	COG0142	geranyltranstransferase activity
EGY22_01650	COG0494	nUDIX hydrolase
EGY22_01655	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
EGY22_01680	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
EGY22_01685	COG0237	dephospho-CoA kinase activity
EGY22_01700	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
EGY22_01705	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
EGY22_01715	COG0477	Major facilitator Superfamily
EGY22_01720	COG0259	pyridoxamine-phosphate oxidase activity
EGY22_01725	COG0019	diaminopimelate decarboxylase activity
EGY22_01770	COG4206	TonB-dependent receptor
EGY22_01775	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EGY22_01790	COG1595	DNA-templated transcription, initiation
EGY22_01800	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
EGY22_01820	COG0598	Magnesium transport protein CorA
EGY22_01835	COG2022	thiamine diphosphate biosynthetic process
EGY22_01840	COG0351	phosphomethylpyrimidine kinase
EGY22_01845	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
EGY22_01850	COG3344	reverse transcriptase
EGY22_01855	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
EGY22_01860	COG1538	Outer membrane efflux protein
EGY22_01865	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
EGY22_01875	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
EGY22_01890	COG2226	methyltransferase
EGY22_01895	COG0745	RESPONSE REGULATOR receiver
EGY22_01910	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
EGY22_01915	COG1984	allophanate hydrolase subunit 2
EGY22_01920	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
EGY22_01925	COG1238	metal cluster binding
EGY22_01955	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
EGY22_01960	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
EGY22_01965	COG4988	ABC transporter
EGY22_01975	COG1294	oxidase, subunit
EGY22_01980	COG1271	oxidase subunit
EGY22_01995	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
EGY22_02010	COG1137	ATPase activity
EGY22_02020	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
EGY22_02025	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
EGY22_02030	COG1660	Displays ATPase and GTPase activities
EGY22_02040	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
EGY22_02045	COG0792	nuclease activity
EGY22_02050	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
EGY22_02065	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
EGY22_02085	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
EGY22_02090	COG0793	Belongs to the peptidase S41A family
EGY22_02100	COG0588	phosphoglycerate mutase activity
EGY22_02105	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EGY22_02115	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
EGY22_02120	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
EGY22_02125	COG3181	Tripartite tricarboxylate transporter family receptor
EGY22_02130	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
EGY22_02135	COG1040	competence protein
EGY22_02140	COG2226	methyltransferase
EGY22_02145	COG4771	TonB-dependent receptor
EGY22_02150	COG0745	RESPONSE REGULATOR receiver
EGY22_02165	COG2204	response regulator
EGY22_02195	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
EGY22_02200	COG3473	Maleate cis-trans isomerase
EGY22_02215	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
EGY22_02230	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
EGY22_02230	COG2755	lipolytic protein G-D-S-L family
EGY22_02240	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
EGY22_02245	COG1216	Glycosyl transferase, family 2
EGY22_02255	COG3039	Transposase
EGY22_02330	COG0355	proton-transporting ATP synthase activity, rotational mechanism
EGY22_02335	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
EGY22_02340	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
EGY22_02345	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
EGY22_02350	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
EGY22_02355	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
EGY22_02365	COG0356	it plays a direct role in the translocation of protons across the membrane
EGY22_02375	COG1024	Enoyl-CoA hydratase
EGY22_02390	COG0037	tRNA processing
EGY22_02395	COG0163	prenyltransferase activity
EGY22_02400	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
EGY22_02405	COG2890	protein-(glutamine-N5) methyltransferase activity
EGY22_02415	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
EGY22_02445	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
EGY22_02450	COG2264	protein methyltransferase activity
EGY22_02455	COG4773	Receptor
EGY22_02480	COG3180	Ammonia monooxygenase
EGY22_02500	COG5002	protein histidine kinase activity
EGY22_02515	COG0477	Major facilitator Superfamily
EGY22_02520	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
EGY22_02540	COG1116	anion transmembrane transporter activity
EGY22_02565	COG3383	formate dehydrogenase (NAD+) activity
EGY22_02565	COG0243	molybdopterin cofactor binding
EGY22_02570	COG0243	molybdopterin cofactor binding
EGY22_02570	COG3383	formate dehydrogenase (NAD+) activity
EGY22_02575	COG0437	4 iron, 4 sulfur cluster binding
EGY22_02580	COG2864	formate dehydrogenase
EGY22_02590	COG1921	L-seryl-tRNASec selenium transferase activity
EGY22_02595	COG3276	selenocysteine insertion sequence binding
EGY22_02605	COG1476	TRANSCRIPTIONal
EGY22_02610	COG0235	Class ii aldolase
EGY22_02620	COG3181	Tripartite tricarboxylate transporter family receptor
EGY22_02640	COG0709	Synthesizes selenophosphate from selenide and ATP
EGY22_02655	COG0583	DNA-binding transcription factor activity
EGY22_02660	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
EGY22_02665	COG0348	domain, Protein
EGY22_02665	COG3901	Regulator of nitric oxide reductase transcription
EGY22_02670	COG4263	nitrous-oxide reductase activity
EGY22_02685	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
EGY22_02700	COG0166	Belongs to the GPI family
EGY22_02725	COG1215	transferase activity, transferring glycosyl groups
EGY22_02765	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
EGY22_02800	COG0156	8-amino-7-oxononanoate synthase activity
EGY22_02815	COG2233	PERMEase
EGY22_02820	COG0697	spore germination
EGY22_02825	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EGY22_02830	COG0697	spore germination
EGY22_02850	COG2885	chlorophyll binding
EGY22_02935	COG3501	Rhs element vgr protein
EGY22_02945	COG0183	Belongs to the thiolase family
EGY22_02950	COG1250	3-hydroxyacyl-CoA dehydrogenase
EGY22_02950	COG1024	Enoyl-CoA hydratase
EGY22_02965	COG1127	ABC transporter
EGY22_02970	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
EGY22_02975	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
EGY22_02990	COG1131	(ABC) transporter
EGY22_02995	COG0842	Transport permease protein
EGY22_03005	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
EGY22_03010	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
EGY22_03015	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
EGY22_03020	COG0131	Imidazoleglycerol-phosphate dehydratase
EGY22_03030	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
EGY22_03035	COG0107	imidazoleglycerol-phosphate synthase activity
EGY22_03040	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
EGY22_03045	COG0140	phosphoribosyl-ATP diphosphatase activity
EGY22_03050	COG0537	adenosine 5'-monophosphoramidase activity
EGY22_03055	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
EGY22_03070	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EGY22_03080	COG1970	mechanosensitive ion channel activity
EGY22_03085	COG0723	plastoquinol--plastocyanin reductase activity
EGY22_03090	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
EGY22_03095	COG2857	Cytochrome c1
EGY22_03100	COG0625	glutathione transferase activity
EGY22_03105	COG2969	positive regulation of protein catabolic process
EGY22_03110	COG4208	sulfate ABC transporter
EGY22_03115	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
EGY22_03120	COG4150	thiosulfate binding
EGY22_03135	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
EGY22_03155	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
EGY22_03160	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EGY22_03165	COG3622	Belongs to the hyi family
EGY22_03175	COG0129	dihydroxy-acid dehydratase activity
EGY22_03180	COG1802	Transcriptional regulator
EGY22_03185	COG1522	sequence-specific DNA binding
EGY22_03190	COG3483	tryptophan 2,3-dioxygenase activity
EGY22_03210	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
EGY22_03215	COG0656	L-ascorbic acid biosynthetic process
EGY22_03225	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
EGY22_03230	COG3706	GGDEF domain
EGY22_03235	COG2226	methyltransferase
EGY22_03245	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
EGY22_03260	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
EGY22_03265	COG0583	DNA-binding transcription factor activity
EGY22_03270	COG0477	Major facilitator Superfamily
EGY22_03275	COG1028	Short-chain dehydrogenase reductase Sdr
EGY22_03285	COG1335	isochorismatase
EGY22_03290	COG1335	isochorismatase
EGY22_03310	COG2823	Periplasmic or secreted lipoprotein
EGY22_03320	COG3284	Transcriptional regulator
EGY22_03350	COG1595	DNA-templated transcription, initiation
EGY22_03355	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
EGY22_03360	COG1522	sequence-specific DNA binding
EGY22_03370	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
EGY22_03390	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
EGY22_03425	COG0109	protoheme IX farnesyltransferase activity
EGY22_03445	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
EGY22_03450	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
EGY22_03465	COG3568	Endonuclease Exonuclease Phosphatase
EGY22_03470	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
EGY22_03495	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EGY22_03505	COG1228	amidohydrolase
EGY22_03525	COG2986	histidine ammonia-lyase
EGY22_03530	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
EGY22_03560	COG2814	Major facilitator Superfamily
EGY22_03570	COG0789	Transcriptional regulator
EGY22_03600	COG0625	glutathione transferase activity
EGY22_03610	COG1017	nitric oxide dioxygenase activity
EGY22_03610	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
EGY22_03630	COG2365	Tyrosine phosphatase family
EGY22_03635	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
EGY22_03655	COG2423	ornithine cyclodeaminase activity
EGY22_03705	COG3069	C4-dicarboxylate transmembrane transporter activity
EGY22_03715	COG1802	Transcriptional regulator
EGY22_03725	COG2814	Major facilitator Superfamily
EGY22_03740	COG2814	Major facilitator Superfamily
EGY22_03745	COG0251	oxidation-reduction process
EGY22_03750	COG3181	Tripartite tricarboxylate transporter family receptor
EGY22_03755	COG0179	Fumarylacetoacetate (FAA) hydrolase
EGY22_03760	COG2186	Transcriptional regulator
EGY22_03770	COG2814	Major facilitator Superfamily
EGY22_03780	COG0232	Belongs to the dGTPase family. Type 2 subfamily
EGY22_03785	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
EGY22_03790	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
EGY22_03810	COG5002	protein histidine kinase activity
EGY22_03810	COG5001	Diguanylate cyclase
EGY22_03825	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
EGY22_03830	COG1333	cytochrome c biogenesis protein
EGY22_03840	COG0218	Necessary for normal cell division and for the maintenance of normal septation
EGY22_03845	COG0113	porphobilinogen synthase activity
EGY22_03850	COG4232	protein-disulfide reductase activity
EGY22_03870	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EGY22_03875	COG0203	ribosomal protein L17
EGY22_03880	COG0202	RNA polymerase activity
EGY22_03885	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
EGY22_03890	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
EGY22_03895	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
EGY22_03900	COG0257	Belongs to the bacterial ribosomal protein bL36 family
EGY22_03910	COG0201	protein transport
EGY22_03915	COG0200	Binds to the 23S rRNA
EGY22_03920	COG1841	ribosomal large subunit assembly
EGY22_03925	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
EGY22_03930	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
EGY22_03935	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
EGY22_03940	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
EGY22_03945	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
EGY22_03950	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
EGY22_03955	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
EGY22_03960	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
EGY22_04000	COG1538	Outer membrane efflux protein
EGY22_04015	COG1960	acyl-CoA dehydrogenase activity
EGY22_04020	COG0183	Belongs to the thiolase family
EGY22_04030	COG2067	long-chain fatty acid transport protein
EGY22_04045	COG0318	PFAM AMP-dependent synthetase and ligase
EGY22_04050	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
EGY22_04055	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
EGY22_04060	COG1648	precorrin-2 dehydrogenase activity
EGY22_04060	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
EGY22_04075	COG1116	anion transmembrane transporter activity
EGY22_04095	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
EGY22_04100	COG0255	Belongs to the universal ribosomal protein uL29 family
EGY22_04105	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
EGY22_04110	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
EGY22_04115	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
EGY22_04120	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
EGY22_04125	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
EGY22_04130	COG0089	rRNA binding
EGY22_04135	COG0088	Forms part of the polypeptide exit tunnel
EGY22_04140	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
EGY22_04145	COG4175	Glycine betaine
EGY22_04150	COG4176	ABC-type proline glycine betaine transport system permease component
EGY22_04160	COG0051	transcription antitermination factor activity, RNA binding
EGY22_04165	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
EGY22_04170	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
EGY22_04175	COG0049	tRNA binding
EGY22_04180	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
EGY22_04185	COG0745	RESPONSE REGULATOR receiver
EGY22_04210	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
EGY22_04215	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
EGY22_04220	COG0085	RNA polymerase activity
EGY22_04225	COG0222	ribosome binding
EGY22_04230	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
EGY22_04240	COG0081	regulation of translation
EGY22_04245	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
EGY22_04265	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
EGY22_04290	COG1475	DNA binding
EGY22_04295	COG1192	Involved in chromosome partitioning
EGY22_04305	COG0445	tRNA wobble uridine modification
EGY22_04310	COG0436	Aminotransferase
EGY22_04315	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
EGY22_04320	COG3706	GGDEF domain
EGY22_04325	COG0688	phosphatidylethanolamine metabolic process
EGY22_04335	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
EGY22_04375	COG3645	SOS response
EGY22_04380	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
EGY22_04425	COG0559	Belongs to the binding-protein-dependent transport system permease family
EGY22_04445	COG0596	Alpha beta hydrolase
EGY22_04450	COG2309	aminopeptidase activity
EGY22_04455	COG1335	isochorismatase
EGY22_04480	COG0753	catalase activity
EGY22_04485	COG0706	membrane insertase activity
EGY22_04490	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
EGY22_04495	COG0594	ribonuclease P activity
EGY22_04500	COG0230	Belongs to the bacterial ribosomal protein bL34 family
EGY22_04510	COG0592	DNA-directed DNA polymerase activity
EGY22_04520	COG1187	pseudouridine synthase activity
EGY22_04535	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
EGY22_04565	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
EGY22_04570	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EGY22_04590	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EGY22_04610	COG2070	2-Nitropropane dioxygenase
EGY22_04620	COG1960	acyl-CoA dehydrogenase activity
EGY22_04630	COG1804	L-carnitine dehydratase bile acid-inducible protein F
EGY22_04640	COG1804	L-carnitine dehydratase bile acid-inducible protein F
EGY22_04650	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
EGY22_04670	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
EGY22_04675	COG0583	DNA-binding transcription factor activity
EGY22_04685	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
EGY22_04695	COG0559	Belongs to the binding-protein-dependent transport system permease family
EGY22_04710	COG0318	PFAM AMP-dependent synthetase and ligase
EGY22_04720	COG0508	dehydrogenase complex catalyzes the overall conversion of
EGY22_04720	COG0596	Alpha beta hydrolase
EGY22_04725	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EGY22_04740	COG3181	Tripartite tricarboxylate transporter family receptor
EGY22_04750	COG0697	spore germination
EGY22_04755	COG0583	DNA-binding transcription factor activity
EGY22_04765	COG3842	ATPase activity
EGY22_04785	COG0523	cobalamin synthesis protein
EGY22_04845	COG1846	Transcriptional regulator
EGY22_04865	COG0179	Fumarylacetoacetate (FAA) hydrolase
EGY22_04870	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
EGY22_04875	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
EGY22_04885	COG4638	Rieske (2fe-2S)
EGY22_04910	COG1028	Short-chain dehydrogenase reductase Sdr
EGY22_04940	COG1028	Short-chain dehydrogenase reductase Sdr
EGY22_04950	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
EGY22_04960	COG2207	Transcriptional regulator
EGY22_04995	COG1595	DNA-templated transcription, initiation
EGY22_05000	COG4608	Belongs to the ABC transporter superfamily
EGY22_05005	COG0444	Belongs to the ABC transporter superfamily
EGY22_05010	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EGY22_05025	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
EGY22_05030	COG1595	DNA-templated transcription, initiation
EGY22_05035	COG3712	iron ion homeostasis
EGY22_05040	COG4774	siderophore transport
EGY22_05045	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
EGY22_05050	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
EGY22_05065	COG1464	Belongs to the NlpA lipoprotein family
EGY22_05070	COG1464	Belongs to the NlpA lipoprotein family
EGY22_05075	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
EGY22_05080	COG2011	ABC-type metal ion transport system permease component
EGY22_05105	COG1464	Belongs to the NlpA lipoprotein family
EGY22_05115	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
EGY22_05135	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EGY22_05140	COG0431	NADPH-dependent FMN reductase
EGY22_05175	COG4149	molybdate abc transporter
EGY22_05185	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
EGY22_05190	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
EGY22_05200	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
EGY22_05220	COG0028	Belongs to the TPP enzyme family
EGY22_05225	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
EGY22_05255	COG2922	Belongs to the Smg family
EGY22_05270	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
EGY22_05275	COG0183	Belongs to the thiolase family
EGY22_05280	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
EGY22_05285	COG1960	acyl-CoA dehydrogenase activity
EGY22_05310	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
EGY22_05320	COG0018	arginyl-trna synthetase
EGY22_05345	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
EGY22_05355	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
EGY22_05360	COG4774	siderophore transport
EGY22_05365	COG0066	3-isopropylmalate dehydratase activity
EGY22_05370	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
EGY22_05375	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
EGY22_05380	COG1804	L-carnitine dehydratase bile acid-inducible protein F
EGY22_05385	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
EGY22_05395	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
EGY22_05400	COG1335	isochorismatase
EGY22_05405	COG0583	DNA-binding transcription factor activity
EGY22_05425	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
EGY22_05430	COG1280	lysine exporter protein (LysE YggA)
EGY22_05435	COG0513	Belongs to the DEAD box helicase family
EGY22_05445	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
EGY22_05460	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
EGY22_05475	COG0154	amidase activity
EGY22_05490	COG0583	DNA-binding transcription factor activity
EGY22_05520	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
EGY22_05525	COG1127	ABC transporter
EGY22_05530	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
EGY22_05530	COG3218	ABC-type transport auxiliary lipoprotein component
EGY22_05545	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EGY22_05550	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
EGY22_05560	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
EGY22_05590	COG0583	DNA-binding transcription factor activity
EGY22_05610	COG3093	addiction module antidote protein HigA
EGY22_05625	COG1254	Belongs to the acylphosphatase family
EGY22_05645	COG0564	pseudouridine synthase activity
EGY22_05650	COG0252	asparaginase activity
EGY22_05675	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
EGY22_05680	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
EGY22_05685	COG3181	Tripartite tricarboxylate transporter family receptor
EGY22_05700	COG0411	ABC transporter
EGY22_05705	COG0559	Belongs to the binding-protein-dependent transport system permease family
EGY22_05730	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EGY22_05745	COG0758	DNA mediated transformation
EGY22_05750	COG0242	peptide deformylase activity
EGY22_05755	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
EGY22_05760	COG0697	spore germination
EGY22_05775	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
EGY22_05790	COG4336	lyase activity
EGY22_05795	COG0583	DNA-binding transcription factor activity
EGY22_05800	COG0859	PFAM glycosyl transferase family 9
EGY22_05810	COG1278	Cold shock
EGY22_05815	COG1210	Utp--glucose-1-phosphate uridylyltransferase
EGY22_05820	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
EGY22_05825	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
EGY22_05825	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
EGY22_05835	COG1686	Belongs to the peptidase S11 family
EGY22_05845	COG2921	Belongs to the UPF0250 family
EGY22_05850	COG0321	lipoyl(octanoyl) transferase activity
EGY22_05855	COG1024	Enoyl-CoA hydratase
EGY22_05860	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
EGY22_05870	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
EGY22_05950	COG0134	indole-3-glycerol-phosphate synthase activity
EGY22_05955	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
EGY22_05960	COG0512	Glutamine amidotransferase of anthranilate synthase
EGY22_05970	COG0546	phosphoglycolate phosphatase activity
EGY22_05985	COG2967	ApaG domain
EGY22_05990	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
EGY22_05995	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EGY22_06000	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
EGY22_06010	COG0840	transmembrane signaling receptor activity
EGY22_06020	COG1028	Short-chain dehydrogenase reductase Sdr
EGY22_06025	COG3433	isochorismatase activity
EGY22_06025	COG1535	isochorismatase
EGY22_06030	COG1169	isochorismate synthase
EGY22_06045	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
EGY22_06045	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
EGY22_06050	COG1535	isochorismatase
EGY22_06050	COG3433	isochorismatase activity
EGY22_06055	COG1021	2,3-dihydroxybenzoate-AMP ligase
EGY22_06065	COG0410	ABC transporter
EGY22_06070	COG0411	ABC transporter
EGY22_06085	COG0683	leucine binding
EGY22_06100	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EGY22_06135	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
EGY22_06140	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EGY22_06145	COG2819	hydrolase of the alpha beta superfamily
EGY22_06150	COG0513	Belongs to the DEAD box helicase family
EGY22_06155	COG2814	Major facilitator Superfamily
EGY22_06165	COG0583	DNA-binding transcription factor activity
EGY22_06175	COG1253	flavin adenine dinucleotide binding
EGY22_06210	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
EGY22_06230	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
EGY22_06250	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EGY22_06255	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
EGY22_06265	COG0583	DNA-binding transcription factor activity
EGY22_06270	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EGY22_06280	COG0765	amino acid transport
EGY22_06285	COG0765	amino acid transport
EGY22_06305	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
EGY22_06320	COG3391	amine dehydrogenase activity
EGY22_06330	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
EGY22_06355	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
EGY22_06360	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
EGY22_06365	COG0210	DNA helicase
EGY22_06375	COG0070	glutamate synthase
EGY22_06375	COG0069	glutamate synthase activity
EGY22_06375	COG0067	glutamate synthase
EGY22_06380	COG1024	Enoyl-CoA hydratase
EGY22_06390	COG1804	L-carnitine dehydratase bile acid-inducible protein F
EGY22_06395	COG1250	3-hydroxyacyl-CoA dehydrogenase
EGY22_06425	COG2918	glutathione biosynthetic process
EGY22_06435	COG2197	response regulator
EGY22_06440	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
EGY22_06450	COG2223	nitrite transmembrane transporter activity
EGY22_06455	COG2860	membrane
EGY22_06460	COG1346	cytolysis
EGY22_06475	COG0251	oxidation-reduction process
EGY22_06490	COG5295	Hep Hag repeat protein
EGY22_06505	COG1280	lysine exporter protein (LysE YggA)
EGY22_06515	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
EGY22_06530	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
EGY22_06545	COG2096	Adenosyltransferase
EGY22_06560	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
EGY22_06565	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
EGY22_06570	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
EGY22_06575	COG0523	cobalamin synthesis protein
EGY22_06580	COG0735	belongs to the Fur family
EGY22_06590	COG1108	ABC-type Mn2 Zn2 transport systems permease components
EGY22_06595	COG0803	Belongs to the bacterial solute-binding protein 9 family
EGY22_06600	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
EGY22_06610	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
EGY22_06615	COG1560	Kdo2-lipid A biosynthetic process
EGY22_06625	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
EGY22_06630	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
EGY22_06635	COG1950	PFAM Membrane protein of
EGY22_06670	COG0275	rRNA processing
EGY22_06675	COG0730	response to heat
EGY22_06680	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
EGY22_06685	COG0129	dihydroxy-acid dehydratase activity
EGY22_06690	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
EGY22_06710	COG3181	Tripartite tricarboxylate transporter family receptor
EGY22_06720	COG0628	permease
EGY22_06735	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
EGY22_06750	COG1028	Short-chain dehydrogenase reductase Sdr
EGY22_06775	COG1021	2,3-dihydroxybenzoate-AMP ligase
EGY22_06790	COG2814	Major facilitator Superfamily
EGY22_06800	COG0656	L-ascorbic acid biosynthetic process
EGY22_06805	COG2814	Major facilitator Superfamily
EGY22_06810	COG0583	DNA-binding transcription factor activity
EGY22_06820	COG3685	Protein conserved in bacteria
EGY22_06840	COG1846	Transcriptional regulator
EGY22_06855	COG4774	siderophore transport
EGY22_06860	COG4607	ABC-type enterochelin transport system periplasmic component
EGY22_06865	COG4604	ABC transporter, ATP-binding protein
EGY22_06870	COG4605	iron ion homeostasis
EGY22_06875	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EGY22_06890	COG0277	FAD linked oxidase domain protein
EGY22_06895	COG1304	FMN binding
EGY22_06900	COG2186	Transcriptional regulator
EGY22_06920	COG1609	Transcriptional regulator
EGY22_06925	COG1522	sequence-specific DNA binding
EGY22_06930	COG3844	kynureninase activity
EGY22_06935	COG1113	amino acid transport
EGY22_06965	COG3181	Tripartite tricarboxylate transporter family receptor
EGY22_06970	COG1349	DNA-binding transcription factor activity
EGY22_06975	COG3842	ATPase activity
EGY22_06990	COG0395	ABC-type sugar transport system, permease component
EGY22_07015	COG0861	Integral membrane protein TerC family
EGY22_07020	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EGY22_07030	COG1671	Belongs to the UPF0178 family
EGY22_07040	COG1418	mRNA catabolic process
EGY22_07050	COG4948	Mandelate Racemase Muconate Lactonizing
EGY22_07060	COG0477	Major facilitator Superfamily
EGY22_07075	COG0154	amidase activity
EGY22_07085	COG0583	DNA-binding transcription factor activity
EGY22_07110	COG0326	Molecular chaperone. Has ATPase activity
EGY22_07120	COG3128	pkhd-type hydroxylase
EGY22_07130	COG3023	N-Acetylmuramoyl-L-alanine amidase
EGY22_07145	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
EGY22_07150	COG1652	LysM domain
EGY22_07165	COG0220	tRNA (guanine-N7-)-methyltransferase activity
EGY22_07190	COG3433	isochorismatase activity
EGY22_07190	COG1535	isochorismatase
EGY22_07215	COG0583	DNA-binding transcription factor activity
EGY22_07220	COG0387	Pfam Sodium calcium exchanger
EGY22_07225	COG3706	GGDEF domain
EGY22_07225	COG0745	RESPONSE REGULATOR receiver
EGY22_07235	COG0477	Major facilitator Superfamily
EGY22_07240	COG0235	Class ii aldolase
EGY22_07250	COG3391	amine dehydrogenase activity
EGY22_07255	COG0590	tRNA wobble adenosine to inosine editing
EGY22_07260	COG3257	ureidoglycine aminohydrolase activity
EGY22_07265	COG0583	DNA-binding transcription factor activity
EGY22_07270	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
EGY22_07275	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EGY22_07275	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EGY22_07285	COG0489	protein tyrosine kinase activity
EGY22_07300	COG0717	Belongs to the dCTP deaminase family
EGY22_07305	COG1982	Orn Lys Arg decarboxylase major
EGY22_07310	COG2081	HI0933 family
EGY22_07315	COG0509	glycine decarboxylation via glycine cleavage system
EGY22_07325	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
EGY22_07330	COG1765	OsmC-like protein
EGY22_07335	COG3278	Belongs to the heme-copper respiratory oxidase family
EGY22_07360	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
EGY22_07365	COG0469	pyruvate kinase activity
EGY22_07370	COG3193	protein, possibly involved in utilization of glycolate and propanediol
EGY22_07380	COG2084	Dehydrogenase
EGY22_07385	COG3622	Belongs to the hyi family
EGY22_07390	COG3960	tartronate-semialdehyde synthase activity
EGY22_07395	COG0583	DNA-binding transcription factor activity
EGY22_07405	COG2233	PERMEase
EGY22_07410	COG1942	4-Oxalocrotonate Tautomerase
EGY22_07415	COG0235	Class ii aldolase
EGY22_07425	COG3195	allantoin biosynthetic process
EGY22_07425	COG3648	Uricase
EGY22_07435	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
EGY22_07440	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
EGY22_07455	COG0438	transferase activity, transferring glycosyl groups
EGY22_07465	COG0438	transferase activity, transferring glycosyl groups
EGY22_07475	COG0277	FAD linked oxidase domain protein
EGY22_07485	COG0179	Fumarylacetoacetate (FAA) hydrolase
EGY22_07490	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
EGY22_07500	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EGY22_07510	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
EGY22_07520	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
EGY22_07535	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
EGY22_07540	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
EGY22_07545	COG0193	aminoacyl-tRNA hydrolase activity
EGY22_07555	COG0012	GTP binding
EGY22_07575	COG1024	Enoyl-CoA hydratase
EGY22_07580	COG0367	asparagine synthase
EGY22_07595	COG0488	(ABC) transporter
EGY22_07610	COG0288	reversible hydration of carbon dioxide
EGY22_07615	COG0583	DNA-binding transcription factor activity
EGY22_07645	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
EGY22_07655	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EGY22_07660	COG3088	subunit of a heme lyase
EGY22_07665	COG4235	cytochrome complex assembly
EGY22_07670	COG0785	Cytochrome C biogenesis protein
EGY22_07680	COG2169	Transcriptional regulator
EGY22_07680	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
EGY22_07700	COG0559	Belongs to the binding-protein-dependent transport system permease family
EGY22_07710	COG0411	ABC transporter
EGY22_07715	COG0410	ABC transporter
EGY22_07720	COG1858	cytochrome C peroxidase
EGY22_07725	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
EGY22_07730	COG1959	2 iron, 2 sulfur cluster binding
EGY22_07735	COG2346	COG2346, Truncated hemoglobins
EGY22_07740	COG0463	Glycosyl transferase, family 2
EGY22_07780	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
EGY22_07785	COG3383	formate dehydrogenase (NAD+) activity
EGY22_07800	COG1910	domain protein
EGY22_07805	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
EGY22_07815	COG0303	'Molybdopterin
EGY22_07820	COG0521	Mo-molybdopterin cofactor biosynthetic process
EGY22_07825	COG0314	molybdopterin synthase activity
EGY22_07835	COG0315	cyclic pyranopterin monophosphate synthase activity
EGY22_07865	COG0678	peroxiredoxin activity
EGY22_07880	COG0697	spore germination
EGY22_07885	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
EGY22_07965	COG0815	Transfers the fatty acyl group on membrane lipoproteins
EGY22_07970	COG4535	Mg2 and Co2 transporter CorC
EGY22_07975	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
EGY22_07980	COG1702	phosphate starvation-inducible protein PhoH
EGY22_07985	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
EGY22_07995	COG0024	Methionine aminopeptidase
EGY22_08000	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EGY22_08005	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EGY22_08010	COG1862	Preprotein translocase
EGY22_08015	COG0343	queuine tRNA-ribosyltransferase activity
EGY22_08020	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
EGY22_08025	COG2027	D-alanyl-D-alanine carboxypeptidase
EGY22_08030	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
EGY22_08040	COG4575	ribosome binding
EGY22_08055	COG0583	DNA-binding transcription factor activity
EGY22_08070	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EGY22_08085	COG0154	amidase activity
EGY22_08095	COG0477	Major facilitator Superfamily
EGY22_08110	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
EGY22_08120	COG0436	Aminotransferase
EGY22_08130	COG0281	malic enzyme
EGY22_08130	COG0280	phosphate acetyltransferase
EGY22_08140	COG2732	(Barnase) inhibitor
EGY22_08145	COG1385	rRNA (uridine-N3-)-methyltransferase activity
EGY22_08150	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
EGY22_08155	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
EGY22_08160	COG0126	phosphoglycerate kinase activity
EGY22_08185	COG0521	Mo-molybdopterin cofactor biosynthetic process
EGY22_08195	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
EGY22_08200	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
EGY22_08205	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
EGY22_08210	COG0009	L-threonylcarbamoyladenylate synthase
EGY22_08215	COG0596	Alpha beta hydrolase
EGY22_08220	COG2030	dehydratase
EGY22_08220	COG1012	belongs to the aldehyde dehydrogenase family
EGY22_08225	COG1960	acyl-CoA dehydrogenase activity
EGY22_08235	COG0405	Gamma-glutamyltransferase
EGY22_08245	COG0579	oxidoreductase
EGY22_08250	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
EGY22_08255	COG0259	pyridoxamine-phosphate oxidase activity
EGY22_08265	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
EGY22_08280	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
EGY22_08285	COG1215	transferase activity, transferring glycosyl groups
EGY22_08295	COG0488	(ABC) transporter
EGY22_08315	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
EGY22_08320	COG2894	cell division
EGY22_08330	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
EGY22_08335	COG1271	oxidase subunit
EGY22_08340	COG1294	oxidase, subunit
EGY22_08345	COG0038	chloride channel
EGY22_08355	COG0514	ATP-dependent DNA helicase (RecQ)
EGY22_08360	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
EGY22_08365	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
EGY22_08370	COG0633	Ferredoxin
EGY22_08385	COG2001	Belongs to the MraZ family
EGY22_08390	COG0275	rRNA processing
EGY22_08395	COG3116	cell division
EGY22_08405	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
EGY22_08410	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
EGY22_08415	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
EGY22_08425	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
EGY22_08430	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
EGY22_08435	COG1181	Belongs to the D-alanine--D-alanine ligase family
EGY22_08440	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
EGY22_08450	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
EGY22_08455	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
EGY22_08465	COG0741	lytic transglycosylase activity
EGY22_08465	COG1196	nuclear chromosome segregation
EGY22_08465	COG0739	heme binding
EGY22_08470	COG0653	protein targeting
EGY22_08480	COG2239	Acts as a magnesium transporter
EGY22_08485	COG1607	acyl-coa hydrolase
EGY22_08490	COG1473	amidohydrolase
EGY22_08495	COG0318	PFAM AMP-dependent synthetase and ligase
EGY22_08505	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
EGY22_08505	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EGY22_08520	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
EGY22_08525	COG2011	ABC-type metal ion transport system permease component
EGY22_08535	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EGY22_08540	COG0765	amino acid transport
EGY22_08545	COG1126	abc transporter atp-binding protein
EGY22_08555	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
EGY22_08570	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EGY22_08575	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
EGY22_08580	COG0700	Nucleoside recognition
EGY22_08595	COG0204	Acyl-transferase
EGY22_08600	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
EGY22_08605	COG0751	glycine-tRNA ligase activity
EGY22_08610	COG0752	glycyl-tRNA synthetase alpha subunit
EGY22_08615	COG1024	Enoyl-CoA hydratase
EGY22_08625	COG1309	transcriptional regulator
EGY22_08635	COG2814	Major facilitator Superfamily
EGY22_08650	COG1573	uracil-dna glycosylase
EGY22_08655	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
EGY22_08660	COG0617	tRNA 3'-terminal CCA addition
EGY22_08670	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
EGY22_08675	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
EGY22_08680	COG1953	Uracil, thiamine, allantoin
EGY22_08685	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
EGY22_08690	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
EGY22_08695	COG0586	Pfam SNARE associated Golgi protein
EGY22_08700	COG0860	N-Acetylmuramoyl-L-alanine amidase
EGY22_08705	COG0802	atpase or kinase
EGY22_08715	COG3181	Tripartite tricarboxylate transporter family receptor
EGY22_08720	COG0280	phosphate acetyltransferase
EGY22_08720	COG0281	malic enzyme
EGY22_08725	COG0583	DNA-binding transcription factor activity
EGY22_08730	COG1012	belongs to the aldehyde dehydrogenase family
EGY22_08735	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EGY22_08780	COG1733	regulation of RNA biosynthetic process
EGY22_08785	COG2910	NAD(P)H-binding
EGY22_08795	COG2223	nitrite transmembrane transporter activity
EGY22_08800	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
EGY22_08805	COG4974	Belongs to the 'phage' integrase family
EGY22_08810	COG0725	ABC transporter, periplasmic molybdate-binding protein
EGY22_08815	COG4149	molybdate abc transporter
EGY22_08820	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
EGY22_08835	COG1074	ATP-dependent DNA helicase activity
EGY22_08855	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
EGY22_08870	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EGY22_08880	COG3712	iron ion homeostasis
EGY22_08890	COG3391	amine dehydrogenase activity
EGY22_08895	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
EGY22_08900	COG0505	Belongs to the CarA family
EGY22_08905	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
EGY22_08925	COG2233	PERMEase
EGY22_08930	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
EGY22_08935	COG1534	Rna-binding protein
EGY22_08940	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
EGY22_08945	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
EGY22_08950	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
EGY22_08955	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
EGY22_08965	COG0248	Ppx GppA phosphatase
EGY22_08970	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
EGY22_08990	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
EGY22_08995	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EGY22_09010	COG0745	RESPONSE REGULATOR receiver
EGY22_09015	COG2205	protein histidine kinase activity
EGY22_09030	COG0583	DNA-binding transcription factor activity
EGY22_09045	COG1231	oxidoreductase activity
EGY22_09050	COG2010	Cytochrome c
EGY22_09055	COG2323	membrane
EGY22_09065	COG1368	sulfuric ester hydrolase activity
EGY22_09095	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EGY22_09100	COG3327	negative regulation of DNA-templated transcription, initiation
EGY22_09105	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EGY22_09120	COG0009	L-threonylcarbamoyladenylate synthase
EGY22_09125	COG1994	Peptidase M50
EGY22_09130	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EGY22_09135	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
EGY22_09150	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
EGY22_09160	COG0156	8-amino-7-oxononanoate synthase activity
EGY22_09165	COG2124	cytochrome p450
EGY22_09170	COG3135	benzoate transporter
EGY22_09180	COG2850	peptidyl-arginine hydroxylation
EGY22_09185	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
EGY22_09190	COG3391	amine dehydrogenase activity
EGY22_09200	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EGY22_09205	COG1136	(ABC) transporter
EGY22_09205	COG0577	efflux transmembrane transporter activity
EGY22_09210	COG1538	Outer membrane efflux protein
EGY22_09215	COG0363	glucosamine-6-phosphate deaminase activity
EGY22_09220	COG1132	(ABC) transporter
EGY22_09230	COG3181	Tripartite tricarboxylate transporter family receptor
EGY22_09240	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EGY22_09250	COG0668	transmembrane transport
EGY22_09260	COG3321	synthase
EGY22_09260	COG0604	alcohol dehydrogenase
EGY22_09260	COG1028	Short-chain dehydrogenase reductase Sdr
EGY22_09295	COG0154	amidase activity
EGY22_09300	COG2031	fatty acid transporter
EGY22_09320	COG1253	flavin adenine dinucleotide binding
EGY22_09325	COG1968	undecaprenyl-diphosphatase activity
EGY22_09330	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EGY22_09345	COG0215	cysteine-tRNA ligase activity
EGY22_09355	COG0825	malonyl-CoA metabolic process
EGY22_09360	COG0037	tRNA processing
EGY22_09380	COG0330	HflC and HflK could
EGY22_09390	COG4977	sequence-specific DNA binding
EGY22_09395	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
EGY22_09415	COG4208	sulfate ABC transporter
EGY22_09420	COG3842	ATPase activity
EGY22_09425	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
EGY22_09430	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
EGY22_09435	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
EGY22_09460	COG1304	FMN binding
EGY22_09465	COG0435	Glutathione S-transferase
EGY22_09470	COG0655	NAD(P)H dehydrogenase (quinone) activity
EGY22_09495	COG2363	Small membrane protein
EGY22_09500	COG0598	Magnesium transport protein CorA
EGY22_09505	COG1960	acyl-CoA dehydrogenase activity
EGY22_09515	COG0747	negative chemotaxis
EGY22_09525	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EGY22_09530	COG4172	Belongs to the ABC transporter superfamily
EGY22_09540	COG3284	Transcriptional regulator
EGY22_09545	COG1012	belongs to the aldehyde dehydrogenase family
EGY22_09550	COG1454	alcohol dehydrogenase
EGY22_09555	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
EGY22_09580	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
EGY22_09610	COG3829	transcription factor binding
EGY22_09615	COG0477	Major facilitator Superfamily
EGY22_09625	COG0039	L-malate dehydrogenase activity
EGY22_09630	COG2188	Transcriptional regulator
EGY22_09635	COG2009	succinate dehydrogenase
EGY22_09645	COG1053	succinate dehydrogenase
EGY22_09650	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
EGY22_09655	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
EGY22_09660	COG0372	Belongs to the citrate synthase family
EGY22_09665	COG2186	Transcriptional regulator
EGY22_09670	COG1620	l-lactate permease
EGY22_09675	COG0281	malic enzyme
EGY22_09675	COG0280	phosphate acetyltransferase
EGY22_09685	COG0567	Dehydrogenase, E1 component
EGY22_09690	COG0508	dehydrogenase complex catalyzes the overall conversion of
EGY22_09695	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EGY22_09700	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
EGY22_09720	COG2183	response to ionizing radiation
EGY22_09725	COG1199	ATP-dependent helicase activity
EGY22_09735	COG1733	regulation of RNA biosynthetic process
EGY22_09755	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
EGY22_09755	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EGY22_09785	COG0564	pseudouridine synthase activity
EGY22_09795	COG3243	poly(R)-hydroxyalkanoic acid synthase
EGY22_09800	COG1028	Short-chain dehydrogenase reductase Sdr
EGY22_09805	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
EGY22_09835	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
EGY22_09840	COG1187	pseudouridine synthase activity
EGY22_09845	COG0779	Required for maturation of 30S ribosomal subunits
EGY22_09850	COG2251	uridine kinase activity
EGY22_09850	COG0195	Participates in both transcription termination and antitermination
EGY22_09860	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
EGY22_09865	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
EGY22_09875	COG0446	pyridine nucleotide-disulphide oxidoreductase
EGY22_09885	COG4160	amino acid transport
EGY22_09890	COG4215	(ABC) transporter
EGY22_09910	COG1283	sodium-dependent phosphate transmembrane transporter activity
EGY22_09920	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
EGY22_09935	COG0501	Belongs to the peptidase M48B family
EGY22_09950	COG1722	exodeoxyribonuclease VII activity
EGY22_09955	COG0142	geranyltranstransferase activity
EGY22_09960	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
EGY22_09965	COG1469	GTP cyclohydrolase I activity
EGY22_09970	COG0360	Binds together with S18 to 16S ribosomal RNA
EGY22_09975	COG2965	DNA replication, synthesis of RNA primer
EGY22_09980	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
EGY22_09985	COG0359	binds to the 23S rRNA
EGY22_09990	COG0305	Participates in initiation and elongation during chromosome replication
EGY22_10000	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
EGY22_10005	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
EGY22_10010	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
EGY22_10020	COG0436	Aminotransferase
EGY22_10035	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EGY22_10040	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
EGY22_10045	COG1562	ergosterol biosynthetic process
EGY22_10050	COG1562	ergosterol biosynthetic process
EGY22_10055	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
EGY22_10060	COG1028	Short-chain dehydrogenase reductase Sdr
EGY22_10085	COG3842	ATPase activity
EGY22_10090	COG1176	ABC-type spermidine putrescine transport system, permease component I
EGY22_10095	COG1177	transmembrane transport
EGY22_10100	COG1393	Belongs to the ArsC family
EGY22_10105	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
EGY22_10110	COG0704	Plays a role in the regulation of phosphate uptake
EGY22_10115	COG4251	negative regulation of phosphorylation
EGY22_10115	COG3706	GGDEF domain
EGY22_10115	COG2203	Gaf domain
EGY22_10115	COG5001	Diguanylate cyclase
EGY22_10120	COG0659	secondary active sulfate transmembrane transporter activity
EGY22_10125	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
EGY22_10130	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
EGY22_10130	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
EGY22_10135	COG1643	Atp-dependent helicase
EGY22_10145	COG0438	transferase activity, transferring glycosyl groups
EGY22_10150	COG0726	polysaccharide deacetylase
EGY22_10165	COG0438	transferase activity, transferring glycosyl groups
EGY22_10190	COG1132	(ABC) transporter
EGY22_10205	COG1530	ribonuclease E activity
EGY22_10245	COG2186	Transcriptional regulator
EGY22_10250	COG0277	FAD linked oxidase domain protein
EGY22_10255	COG0277	FAD linked oxidase domain protein
EGY22_10260	COG0247	lactate metabolic process
EGY22_10285	COG1012	belongs to the aldehyde dehydrogenase family
EGY22_10310	COG1012	belongs to the aldehyde dehydrogenase family
EGY22_10340	COG1283	sodium-dependent phosphate transmembrane transporter activity
EGY22_10355	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
EGY22_10365	COG0697	spore germination
EGY22_10385	COG3094	Invasion gene expression up-regulator, SirB
EGY22_10395	COG0640	Transcriptional regulator
EGY22_10420	COG0659	secondary active sulfate transmembrane transporter activity
EGY22_10425	COG1262	PFAM Formylglycine-generating sulfatase enzyme
EGY22_10435	COG2314	TM2 domain
EGY22_10440	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
EGY22_10445	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
EGY22_10450	COG0791	NLP P60 protein
EGY22_10470	COG1360	Flagellar Motor Protein
EGY22_10480	COG0835	chemotaxis
EGY22_10485	COG0840	transmembrane signaling receptor activity
EGY22_10490	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
EGY22_10500	COG0745	RESPONSE REGULATOR receiver
EGY22_10505	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
EGY22_10515	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
EGY22_10525	COG3550	peptidyl-serine autophosphorylation
EGY22_10550	COG1815	bacterial-type flagellum-dependent cell motility
EGY22_10555	COG1558	bacterial-type flagellum-dependent cell motility
EGY22_10560	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
EGY22_10565	COG1749	Flagellar hook protein flgE
EGY22_10575	COG4786	Flagellar basal body rod
EGY22_10585	COG1706	bacterial-type flagellum-dependent cell motility
EGY22_10595	COG1256	bacterial-type flagellum assembly
EGY22_10600	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EGY22_10625	COG2176	DNA-directed DNA polymerase activity
EGY22_10635	COG1987	bacterial-type flagellum assembly
EGY22_10650	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
EGY22_10675	COG1157	protein secretion by the type III secretion system
EGY22_10685	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
EGY22_10690	COG1766	The M ring may be actively involved in energy transduction
EGY22_10695	COG1677	Flagellar hook-basal body complex protein FliE
EGY22_10700	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
EGY22_10725	COG1334	flagellar protein FlaG
EGY22_10730	COG1191	sigma factor activity
EGY22_10755	COG0582	viral genome integration into host DNA
EGY22_10830	COG1262	PFAM Formylglycine-generating sulfatase enzyme
EGY22_10850	COG2733	membrane
EGY22_10855	COG0840	transmembrane signaling receptor activity
EGY22_10860	COG0840	transmembrane signaling receptor activity
EGY22_10885	COG2610	gluconate transmembrane transporter activity
EGY22_10910	COG4974	Belongs to the 'phage' integrase family
EGY22_10970	COG4128	Pfam Zonular occludens toxin
EGY22_11015	COG1538	Outer membrane efflux protein
EGY22_11020	COG4521	taurine ABC transporter
EGY22_11025	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
EGY22_11030	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EGY22_11035	COG1028	Short-chain dehydrogenase reductase Sdr
EGY22_11040	COG0583	DNA-binding transcription factor activity
EGY22_11045	COG2824	Alkylphosphonate utilization operon protein PhnA
EGY22_11055	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
EGY22_11085	COG1192	Involved in chromosome partitioning
EGY22_11095	COG1113	amino acid transport
EGY22_11115	COG0583	DNA-binding transcription factor activity
EGY22_11120	COG3755	Protein conserved in bacteria
EGY22_11125	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
EGY22_11160	COG0446	pyridine nucleotide-disulphide oxidoreductase
EGY22_11185	COG1278	Cold shock
EGY22_11190	COG0642	Histidine kinase
EGY22_11195	COG0745	RESPONSE REGULATOR receiver
EGY22_11200	COG3278	Belongs to the heme-copper respiratory oxidase family
EGY22_11210	COG2863	cytochrome
EGY22_11215	COG3258	Cytochrome c
EGY22_11270	COG0025	NhaP-type Na H and K H
EGY22_11285	COG1289	transmembrane transporter activity
EGY22_11290	COG2252	PERMEase
EGY22_11295	COG0560	Phosphoserine phosphatase
EGY22_11310	COG1999	signal sequence binding
EGY22_11320	COG0069	glutamate synthase activity
EGY22_11330	COG1846	Transcriptional regulator
EGY22_11340	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
EGY22_11380	COG1028	Short-chain dehydrogenase reductase Sdr
EGY22_11390	COG3264	Mechanosensitive ion channel
EGY22_11390	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
EGY22_11395	COG1196	nuclear chromosome segregation
EGY22_11395	COG3264	Mechanosensitive ion channel
EGY22_11400	COG0477	Major facilitator Superfamily
EGY22_11415	COG1396	sequence-specific DNA binding
EGY22_11420	COG3437	response regulator, receiver
EGY22_11425	COG0784	Response regulator, receiver
EGY22_11425	COG2205	protein histidine kinase activity
EGY22_11425	COG2198	Histidine kinase
EGY22_11430	COG2239	Acts as a magnesium transporter
EGY22_11440	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
EGY22_11445	COG1490	D-aminoacyl-tRNA deacylase activity
EGY22_11460	COG0456	acetyltransferase
EGY22_11470	COG0501	Belongs to the peptidase M48B family
EGY22_11475	COG2814	Major facilitator Superfamily
EGY22_11540	COG3706	GGDEF domain
EGY22_11555	COG1522	sequence-specific DNA binding
EGY22_11560	COG0626	cystathionine gamma-synthase activity
EGY22_11570	COG0494	nUDIX hydrolase
EGY22_11575	COG2832	Protein of unknown function (DUF454)
EGY22_11585	COG0137	argininosuccinate synthase activity
EGY22_11590	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
EGY22_11595	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
EGY22_11615	COG1609	Transcriptional regulator
EGY22_11625	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
EGY22_11635	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
EGY22_11640	COG2205	protein histidine kinase activity
EGY22_11645	COG0745	RESPONSE REGULATOR receiver
EGY22_11650	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
EGY22_11660	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
EGY22_11665	COG0268	Binds directly to 16S ribosomal RNA
EGY22_11670	COG0728	peptidoglycan biosynthetic process
EGY22_11680	COG0563	adenylate kinase activity
EGY22_11685	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
EGY22_11690	COG2835	tetraacyldisaccharide 4'-kinase activity
EGY22_11695	COG1663	tetraacyldisaccharide 4'-kinase activity
EGY22_11700	COG0848	biopolymer transport protein
EGY22_11705	COG0811	peptide transport
EGY22_11710	COG1570	exodeoxyribonuclease VII activity
EGY22_11715	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
EGY22_11725	COG0183	Belongs to the thiolase family
EGY22_11735	COG1278	Cold shock
EGY22_11740	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
EGY22_11745	COG0542	response to heat
EGY22_11750	COG2995	paraquat-inducible protein a
EGY22_11755	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
EGY22_11755	COG3008	intermembrane lipid transfer
EGY22_11775	COG0559	Belongs to the binding-protein-dependent transport system permease family
EGY22_11785	COG0411	ABC transporter
EGY22_11805	COG0693	protein deglycase activity
EGY22_11810	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
EGY22_11815	COG0756	dUTP diphosphatase activity
EGY22_11825	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
EGY22_11830	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
EGY22_11835	COG0196	riboflavin kinase activity
EGY22_11840	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
EGY22_11845	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
EGY22_11845	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
EGY22_11855	COG0210	DNA helicase
EGY22_11910	COG0488	(ABC) transporter
EGY22_11915	COG2890	protein-(glutamine-N5) methyltransferase activity
EGY22_11920	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EGY22_11925	COG2171	N-acyltransferase activity
EGY22_11935	COG2207	Transcriptional regulator
EGY22_11945	COG0471	metal ion transport
EGY22_11945	COG3273	potassium ion transport
EGY22_11990	COG0789	Transcriptional regulator
EGY22_12015	COG1804	L-carnitine dehydratase bile acid-inducible protein F
EGY22_12020	COG0544	peptidyl-prolyl cis-trans isomerase activity
EGY22_12025	COG0740	serine-type endopeptidase activity
EGY22_12030	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
EGY22_12035	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
EGY22_12045	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EGY22_12055	COG0556	nucleotide-excision repair
EGY22_12060	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
EGY22_12065	COG1959	2 iron, 2 sulfur cluster binding
EGY22_12070	COG1104	cysteine desulfurase activity
EGY22_12080	COG0316	Belongs to the HesB IscA family
EGY22_12095	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
EGY22_12100	COG4221	oxidoreductase activity
EGY22_12110	COG0840	transmembrane signaling receptor activity
EGY22_12115	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
EGY22_12120	COG0697	spore germination
EGY22_12125	COG0385	Bile acid
EGY22_12135	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
EGY22_12150	COG1136	(ABC) transporter
EGY22_12155	COG0084	hydrolase, TatD family'
EGY22_12165	COG0596	Alpha beta hydrolase
EGY22_12170	COG0613	PHP domain protein
EGY22_12180	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
EGY22_12180	COG0047	phosphoribosylformylglycinamidine synthase activity
EGY22_12205	COG0519	Catalyzes the synthesis of GMP from XMP
EGY22_12205	COG0518	GMP synthase (glutamine-hydrolyzing) activity
EGY22_12210	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
EGY22_12220	COG3311	Transcriptional regulator
EGY22_12235	COG2076	Multidrug Resistance protein
EGY22_12240	COG1028	Short-chain dehydrogenase reductase Sdr
EGY22_12245	COG0583	DNA-binding transcription factor activity
EGY22_12260	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
EGY22_12270	COG1960	acyl-CoA dehydrogenase activity
EGY22_12275	COG0523	cobalamin synthesis protein
EGY22_12280	COG1469	GTP cyclohydrolase I activity
EGY22_12285	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
EGY22_12295	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
EGY22_12300	COG0735	belongs to the Fur family
EGY22_12305	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
EGY22_12325	COG0745	RESPONSE REGULATOR receiver
EGY22_12330	COG2207	Transcriptional regulator
EGY22_12350	COG0583	DNA-binding transcription factor activity
EGY22_12355	COG1289	transmembrane transporter activity
EGY22_12365	COG1566	PFAM secretion protein HlyD family protein
EGY22_12375	COG1942	4-Oxalocrotonate Tautomerase
EGY22_12390	COG3162	membrane
EGY22_12395	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EGY22_12405	COG2070	2-Nitropropane dioxygenase
EGY22_12430	COG1309	transcriptional regulator
EGY22_12445	COG0625	glutathione transferase activity
EGY22_12450	COG0583	DNA-binding transcription factor activity
EGY22_12470	COG0625	glutathione transferase activity
EGY22_12475	COG0740	serine-type endopeptidase activity
EGY22_12530	COG1804	L-carnitine dehydratase bile acid-inducible protein F
EGY22_12540	COG1960	acyl-CoA dehydrogenase activity
EGY22_12560	COG0640	Transcriptional regulator
EGY22_12585	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
EGY22_12615	COG3485	protocatechuate 3,4-dioxygenase
EGY22_12625	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
EGY22_12630	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
EGY22_12640	COG3135	benzoate transporter
EGY22_12645	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
EGY22_12650	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
EGY22_12665	COG4555	ABC transporter
EGY22_12675	COG2197	response regulator
EGY22_12705	COG1846	Transcriptional regulator
EGY22_12710	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EGY22_12715	COG2271	Major facilitator Superfamily
EGY22_12725	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
EGY22_12735	COG0697	spore germination
EGY22_12765	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
EGY22_12770	COG0667	Aldo Keto reductase
EGY22_12785	COG0582	viral genome integration into host DNA
EGY22_12820	COG0629	single-stranded DNA binding
EGY22_13080	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
EGY22_13155	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
EGY22_13160	COG1335	isochorismatase
EGY22_13175	COG2135	peptidase activity
EGY22_13190	COG1272	protein, Hemolysin III
EGY22_13195	COG3422	double-strand break repair
EGY22_13220	COG0765	amino acid transport
EGY22_13225	COG0765	amino acid transport
EGY22_13230	COG1126	abc transporter atp-binding protein
EGY22_13285	COG2871	sodium ion transport
EGY22_13315	COG2814	Major facilitator Superfamily
EGY22_13320	COG1280	lysine exporter protein (LysE YggA)
EGY22_13340	COG0402	S-adenosylhomocysteine deaminase activity
EGY22_13365	COG0330	HflC and HflK could
EGY22_13370	COG1585	Membrane protein implicated in regulation of membrane protease activity
EGY22_13375	COG2226	methyltransferase
EGY22_13385	COG3042	response to heat
EGY22_13395	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EGY22_13410	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
EGY22_13415	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
EGY22_13420	COG0189	ligase activity
EGY22_13430	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
EGY22_13435	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
EGY22_13465	COG0291	Belongs to the bacterial ribosomal protein bL35 family
EGY22_13470	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
EGY22_13475	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
EGY22_13480	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EGY22_13480	COG0072	phenylalanine-tRNA ligase activity
EGY22_13485	COG0776	regulation of translation
EGY22_13495	COG2833	Protein of unknown function (DUF455)
EGY22_13510	COG5265	(ABC) transporter
EGY22_13515	COG1959	2 iron, 2 sulfur cluster binding
EGY22_13520	COG0719	Fe-S assembly protein
EGY22_13525	COG0396	ATPase activity
EGY22_13530	COG0719	Fe-S assembly protein
EGY22_13540	COG0822	iron-sulfur transferase activity
EGY22_13545	COG2151	metal-sulfur cluster biosynthetic enzyme
EGY22_13560	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EGY22_13615	COG3048	D-serine ammonia-lyase activity
EGY22_13620	COG3258	Cytochrome c
EGY22_13635	COG3949	Membrane
EGY22_13650	COG1262	PFAM Formylglycine-generating sulfatase enzyme
EGY22_13665	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
EGY22_13670	COG0569	domain protein
EGY22_13675	COG1902	pentaerythritol trinitrate reductase activity
EGY22_13685	COG1610	YqeY-like protein
EGY22_13690	COG0587	DNA-directed DNA polymerase activity
EGY22_13725	COG3181	Tripartite tricarboxylate transporter family receptor
EGY22_13730	COG0583	DNA-binding transcription factor activity
EGY22_13735	COG1686	Belongs to the peptidase S11 family
EGY22_13750	COG1360	Flagellar Motor Protein
EGY22_13760	COG1028	Short-chain dehydrogenase reductase Sdr
EGY22_13770	COG4221	oxidoreductase activity
EGY22_13775	COG0307	riboflavin synthase, alpha
EGY22_13790	COG1301	dicarboxylic acid transport
EGY22_13795	COG4191	Histidine kinase
EGY22_13840	COG2233	PERMEase
EGY22_13845	COG0071	Belongs to the small heat shock protein (HSP20) family
EGY22_13860	COG2814	Major facilitator Superfamily
EGY22_13890	COG2816	NAD+ diphosphatase activity
EGY22_13895	COG1561	YicC-like family, N-terminal region
EGY22_13910	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
EGY22_13915	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
EGY22_13920	COG0635	Involved in the biosynthesis of porphyrin-containing compound
EGY22_13930	COG2153	protein acetylation
EGY22_13950	COG3842	ATPase activity
EGY22_13955	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
EGY22_13960	COG1840	ABC-type Fe3 transport system, periplasmic component
EGY22_13975	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
EGY22_13985	COG0783	Belongs to the Dps family
EGY22_13995	COG3842	ATPase activity
EGY22_14000	COG0395	ABC-type sugar transport system, permease component
EGY22_14005	COG1175	transmembrane transport
EGY22_14010	COG1653	transport
EGY22_14025	COG0559	Belongs to the binding-protein-dependent transport system permease family
EGY22_14035	COG0411	ABC transporter
EGY22_14045	COG0625	glutathione transferase activity
EGY22_14055	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
EGY22_14060	COG1028	Short-chain dehydrogenase reductase Sdr
EGY22_14065	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
EGY22_14070	COG0114	fumarate hydratase activity
EGY22_14075	COG2133	pyrroloquinoline quinone binding
EGY22_14080	COG2226	methyltransferase
EGY22_14085	COG0589	response to stress
EGY22_14090	COG4654	Cytochrome c, class I
EGY22_14095	COG2207	Transcriptional regulator
EGY22_14100	COG0235	Class ii aldolase
EGY22_14110	COG1012	belongs to the aldehyde dehydrogenase family
EGY22_14115	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EGY22_14120	COG2807	transmembrane transport
EGY22_14130	COG0583	DNA-binding transcription factor activity
EGY22_14160	COG0583	DNA-binding transcription factor activity
EGY22_14165	COG4974	Belongs to the 'phage' integrase family
EGY22_14175	COG2132	Multicopper oxidase
EGY22_14195	COG1028	Short-chain dehydrogenase reductase Sdr
EGY22_14225	COG3038	cytochrome b561
EGY22_14235	COG2353	YceI-like domain
EGY22_14240	COG1393	Belongs to the ArsC family
EGY22_14245	COG0625	glutathione transferase activity
EGY22_14265	COG0084	hydrolase, TatD family'
EGY22_14270	COG0470	DNA polymerase III
EGY22_14280	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
EGY22_14300	COG1960	acyl-CoA dehydrogenase activity
EGY22_14305	COG2914	Belongs to the UPF0125 (RnfH) family
EGY22_14310	COG2867	negative regulation of translational initiation
EGY22_14315	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
EGY22_14320	COG1252	NADH dehydrogenase
EGY22_14335	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
EGY22_14345	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EGY22_14350	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
EGY22_14355	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EGY22_14365	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
EGY22_14370	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EGY22_14380	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EGY22_14390	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
EGY22_14395	COG0575	Belongs to the CDS family
EGY22_14400	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
EGY22_14405	COG0233	cytoplasmic translational termination
EGY22_14410	COG0528	UMP kinase activity
EGY22_14415	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
EGY22_14420	COG0052	Belongs to the universal ribosomal protein uS2 family
EGY22_14425	COG0024	Methionine aminopeptidase
EGY22_14430	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
EGY22_14455	COG1286	toxin biosynthetic process
EGY22_14465	COG0285	dihydrofolate synthase activity
EGY22_14470	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EGY22_14475	COG0508	dehydrogenase complex catalyzes the overall conversion of
EGY22_14480	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
EGY22_14495	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
EGY22_14505	COG1999	signal sequence binding
EGY22_14515	COG0640	Transcriptional regulator
EGY22_14530	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
EGY22_14535	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
EGY22_14540	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
EGY22_14545	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
EGY22_14550	COG1028	Short-chain dehydrogenase reductase Sdr
EGY22_14555	COG1028	Short-chain dehydrogenase reductase Sdr
EGY22_14575	COG0183	Belongs to the thiolase family
EGY22_14595	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
EGY22_14605	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EGY22_14610	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EGY22_14615	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
EGY22_14640	COG0183	Belongs to the thiolase family
EGY22_14650	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
EGY22_14655	COG0583	DNA-binding transcription factor activity
EGY22_14660	COG1982	Orn Lys Arg decarboxylase major
EGY22_14680	COG0194	GDP metabolic process
EGY22_14685	COG1758	RNA polymerase activity
EGY22_14690	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
EGY22_14700	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
EGY22_14705	COG0739	heme binding
EGY22_14710	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EGY22_14715	COG0584	glycerophosphoryl diester phosphodiesterase
EGY22_14720	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
EGY22_14725	COG1187	pseudouridine synthase activity
EGY22_14730	COG3161	chorismate lyase activity
EGY22_14735	COG2814	Major facilitator Superfamily
EGY22_14740	COG0656	L-ascorbic acid biosynthetic process
EGY22_14750	COG0668	transmembrane transport
EGY22_14755	COG0165	Argininosuccinate lyase
EGY22_14770	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EGY22_14780	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
EGY22_14790	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
EGY22_14795	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
EGY22_14800	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
EGY22_14805	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
EGY22_14810	COG2252	PERMEase
EGY22_14815	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EGY22_14835	COG0488	(ABC) transporter
EGY22_14840	COG1619	proteins homologs of microcin C7 resistance protein MccF
EGY22_14845	COG0590	tRNA wobble adenosine to inosine editing
EGY22_14850	COG1131	(ABC) transporter
EGY22_14855	COG0842	Transport permease protein
EGY22_14865	COG1666	GTP binding
EGY22_14870	COG0318	PFAM AMP-dependent synthetase and ligase
EGY22_14875	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
EGY22_14880	COG0519	Catalyzes the synthesis of GMP from XMP
EGY22_14880	COG0518	GMP synthase (glutamine-hydrolyzing) activity
EGY22_14885	COG2207	Transcriptional regulator
EGY22_14895	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EGY22_14900	COG0135	phosphoribosylanthranilate isomerase activity
EGY22_14905	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
EGY22_14915	COG0101	tRNA pseudouridine synthase activity
EGY22_14925	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
EGY22_14930	COG0473	3-isopropylmalate dehydrogenase activity
EGY22_14935	COG0066	3-isopropylmalate dehydratase activity
EGY22_14940	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
EGY22_14950	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
EGY22_14960	COG4566	intracellular signal transduction
EGY22_14975	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
EGY22_14980	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
EGY22_14990	COG1295	ribonuclease BN
EGY22_15000	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
EGY22_15035	COG4964	Belongs to the GSP D family
EGY22_15070	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
EGY22_15080	COG2959	enzyme of heme biosynthesis
EGY22_15090	COG0181	hydroxymethylbilane synthase activity
EGY22_15095	COG0861	Integral membrane protein TerC family
EGY22_15100	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
EGY22_15105	COG0045	succinate-CoA ligase (ADP-forming) activity
EGY22_15115	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
EGY22_15120	COG0583	DNA-binding transcription factor activity
EGY22_15125	COG2137	regulation of response to DNA damage stimulus
EGY22_15130	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
EGY22_15145	COG0477	Major facilitator Superfamily
EGY22_15160	COG0318	PFAM AMP-dependent synthetase and ligase
EGY22_15165	COG1024	Enoyl-CoA hydratase
EGY22_15170	COG3162	membrane
EGY22_15185	COG0540	Belongs to the ATCase OTCase family
EGY22_15200	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EGY22_15215	COG2070	2-Nitropropane dioxygenase
EGY22_15225	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
EGY22_15225	COG2111	Na H antiporter
EGY22_15230	COG1006	Multisubunit Na H antiporter MnhC subunit
EGY22_15235	COG0651	ATP synthesis coupled electron transport
EGY22_15245	COG2212	antiporter activity
EGY22_15260	COG0477	Major facilitator Superfamily
EGY22_15285	COG3158	transport of potassium into the cell
EGY22_15290	COG0642	Histidine kinase
EGY22_15295	COG0745	RESPONSE REGULATOR receiver
EGY22_15315	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
EGY22_15320	COG4208	sulfate ABC transporter
EGY22_15325	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
EGY22_15330	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
EGY22_15345	COG1278	Cold shock
EGY22_15460	COG0740	serine-type endopeptidase activity
EGY22_15560	COG1396	sequence-specific DNA binding
EGY22_15665	COG0776	regulation of translation
EGY22_15670	COG1648	precorrin-2 dehydrogenase activity
EGY22_15670	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
EGY22_15680	COG3391	amine dehydrogenase activity
EGY22_15705	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
EGY22_15705	COG1648	precorrin-2 dehydrogenase activity
EGY22_15715	COG2010	Cytochrome c
EGY22_15720	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EGY22_15725	COG0626	cystathionine gamma-synthase activity
EGY22_15730	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EGY22_15735	COG0557	exoribonuclease II activity
EGY22_15760	COG0765	amino acid transport
EGY22_15765	COG1126	abc transporter atp-binding protein
EGY22_15780	COG1850	ribulose-bisphosphate carboxylase activity
EGY22_15800	COG2375	cellular response to nickel ion
EGY22_15830	COG0583	DNA-binding transcription factor activity
EGY22_15835	COG3842	ATPase activity
EGY22_15840	COG1175	transmembrane transport
EGY22_15845	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EGY22_15850	COG1840	ABC-type Fe3 transport system, periplasmic component
EGY22_15870	COG0412	Dienelactone hydrolase
EGY22_15875	COG3530	Putative quorum-sensing-regulated virulence factor
EGY22_15880	COG0625	glutathione transferase activity
EGY22_15885	COG1741	Belongs to the pirin family
EGY22_15895	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
EGY22_15900	COG2814	Major facilitator Superfamily
EGY22_15905	COG2807	transmembrane transport
EGY22_15910	COG2207	Transcriptional regulator
EGY22_15915	COG3135	benzoate transporter
EGY22_15925	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
EGY22_15940	COG1529	Aldehyde oxidase and xanthine dehydrogenase
EGY22_15950	COG0402	S-adenosylhomocysteine deaminase activity
EGY22_15960	COG0745	RESPONSE REGULATOR receiver
EGY22_15965	COG2205	protein histidine kinase activity
EGY22_15970	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
EGY22_15980	COG0828	Belongs to the bacterial ribosomal protein bS21 family
EGY22_15985	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
EGY22_15990	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
EGY22_15995	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
EGY22_16000	COG0330	HflC and HflK could
EGY22_16005	COG0330	HflC and HflK could
EGY22_16010	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
EGY22_16015	COG1923	regulation of RNA biosynthetic process
EGY22_16025	COG1160	GTP binding
EGY22_16030	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EGY22_16035	COG2976	Protein conserved in bacteria
EGY22_16040	COG0124	histidyl-tRNA synthetase
EGY22_16045	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
EGY22_16055	COG0820	rRNA (adenine-C2-)-methyltransferase activity
EGY22_16060	COG0105	UTP biosynthetic process
EGY22_16070	COG0336	Belongs to the RNA methyltransferase TrmD family
EGY22_16075	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
EGY22_16080	COG0228	four-way junction DNA binding
EGY22_16085	COG0425	Belongs to the sulfur carrier protein TusA family
EGY22_16090	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
EGY22_16105	COG2351	hydroxyisourate hydrolase activity
EGY22_16135	COG1653	transport
EGY22_16140	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EGY22_16155	COG0187	DNA topoisomerase II activity
EGY22_16165	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
EGY22_16170	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
EGY22_16200	COG0601	transmembrane transport
EGY22_16230	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
EGY22_16235	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
EGY22_16240	COG0542	response to heat
EGY22_16245	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EGY22_16260	COG0348	domain, Protein
EGY22_16280	COG3278	Belongs to the heme-copper respiratory oxidase family
EGY22_16290	COG2217	Heavy metal translocating P-type atpase
EGY22_16295	COG2224	Isocitrate lyase
EGY22_16300	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
EGY22_16300	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
EGY22_16315	COG0322	excinuclease ABC activity
EGY22_16320	COG1472	Belongs to the glycosyl hydrolase 3 family
EGY22_16325	COG0736	holo-[acyl-carrier-protein] synthase activity
EGY22_16335	COG2050	protein possibly involved in aromatic compounds catabolism
EGY22_16340	COG1024	Enoyl-CoA hydratase
EGY22_16345	COG1012	belongs to the aldehyde dehydrogenase family
EGY22_16350	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
EGY22_16355	COG2151	metal-sulfur cluster biosynthetic enzyme
EGY22_16360	COG3396	Phenylacetate-CoA oxygenase
EGY22_16365	COG3460	Phenylacetate-CoA oxygenase
EGY22_16370	COG3396	Phenylacetate-CoA oxygenase
EGY22_16375	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
EGY22_16380	COG0501	Belongs to the peptidase M48B family
EGY22_16385	COG1162	GTPase activity
EGY22_16395	COG0335	large ribosomal subunit rRNA binding
EGY22_16415	COG0450	alkyl hydroperoxide reductase
EGY22_16420	COG1960	acyl-CoA dehydrogenase activity
EGY22_16440	COG2951	lytic endotransglycosylase activity
EGY22_16450	COG1596	polysaccharide export
EGY22_16450	COG1555	photosystem II stabilization
EGY22_16455	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EGY22_16460	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
EGY22_16465	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
EGY22_16485	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
EGY22_16490	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
EGY22_16495	COG0287	Prephenate dehydrogenase
EGY22_16505	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
EGY22_16520	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
EGY22_16540	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
EGY22_16550	COG4771	TonB-dependent receptor
EGY22_16565	COG0753	catalase activity
EGY22_16575	COG4335	DNA alkylation repair
EGY22_16585	COG0436	Aminotransferase
EGY22_16595	COG0251	oxidation-reduction process
EGY22_16600	COG1309	transcriptional regulator
EGY22_16655	COG0625	glutathione transferase activity
EGY22_16665	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
EGY22_16670	COG1280	lysine exporter protein (LysE YggA)
EGY22_16690	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EGY22_16700	COG0784	Response regulator, receiver
EGY22_16700	COG2198	Histidine kinase
EGY22_16700	COG2205	protein histidine kinase activity
EGY22_16710	COG2046	Belongs to the sulfate adenylyltransferase family
EGY22_16715	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
EGY22_16720	COG0642	Histidine kinase
EGY22_16730	COG0840	transmembrane signaling receptor activity
EGY22_16735	COG2119	membrane
EGY22_16750	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
EGY22_16755	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
EGY22_16770	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
EGY22_16775	COG2321	neutral zinc metallopeptidase
EGY22_16785	COG2271	Major facilitator Superfamily
EGY22_16790	COG2175	clavaminate synthase activity
EGY22_16795	COG1846	Transcriptional regulator
EGY22_16805	COG0347	Belongs to the P(II) protein family
EGY22_16810	COG0004	ammonium transporteR
EGY22_16815	COG3909	cytochrome
EGY22_16825	COG0625	glutathione transferase activity
EGY22_16830	COG0730	response to heat
EGY22_16835	COG0482	sulfurtransferase activity
EGY22_16840	COG0277	FAD linked oxidase domain protein
EGY22_16845	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
EGY22_16850	COG2879	small protein
EGY22_16855	COG1966	Carbon starvation protein
EGY22_16860	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EGY22_16865	COG0765	amino acid transport
EGY22_16870	COG0765	amino acid transport
EGY22_16875	COG1126	abc transporter atp-binding protein
EGY22_16880	COG0028	Belongs to the TPP enzyme family
EGY22_16885	COG1012	belongs to the aldehyde dehydrogenase family
EGY22_16890	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
EGY22_16895	COG1028	Short-chain dehydrogenase reductase Sdr
EGY22_16900	COG2226	methyltransferase
EGY22_16900	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
EGY22_16900	COG0596	Alpha beta hydrolase
EGY22_16905	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EGY22_16910	COG1116	anion transmembrane transporter activity
EGY22_16925	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
EGY22_16940	COG5285	phytanoyl-CoA dioxygenase
EGY22_16945	COG0662	Cupin 2, conserved barrel domain protein
EGY22_16950	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
EGY22_16955	COG0456	acetyltransferase
EGY22_16960	COG1846	Transcriptional regulator
EGY22_16970	COG0312	modulator of DNA gyrase
EGY22_16985	COG0308	aminopeptidase N
EGY22_16990	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
EGY22_17005	COG0473	3-isopropylmalate dehydrogenase activity
EGY22_17015	COG0433	COG0433 Predicted ATPase
EGY22_17020	COG0217	transcriptional regulatory protein
EGY22_17025	COG0151	Belongs to the GarS family
EGY22_17030	COG0408	coproporphyrinogen oxidase activity
EGY22_17035	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
EGY22_17040	COG0799	negative regulation of ribosome biogenesis
EGY22_17045	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
EGY22_17050	COG0424	maF-like protein
EGY22_17070	COG0023	Translation Initiation Factor
EGY22_17080	COG2084	Dehydrogenase
EGY22_17085	COG0625	glutathione transferase activity
EGY22_17090	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
EGY22_17095	COG1047	Peptidyl-prolyl cis-trans
EGY22_17100	COG2003	Belongs to the UPF0758 family
EGY22_17105	COG1737	Transcriptional regulator
EGY22_17110	COG0477	Major facilitator Superfamily
EGY22_17120	COG2271	Major facilitator Superfamily
EGY22_17125	COG0254	rRNA binding
EGY22_17135	COG0534	Mate efflux family protein
EGY22_17140	COG4175	Glycine betaine
EGY22_17145	COG4176	ABC-type proline glycine betaine transport system permease component
EGY22_17155	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
EGY22_17160	COG2814	Major facilitator Superfamily
EGY22_17165	COG0227	Belongs to the bacterial ribosomal protein bL28 family
EGY22_17170	COG0267	Belongs to the bacterial ribosomal protein bL33 family
EGY22_17175	COG0495	leucyl-tRNA aminoacylation
EGY22_17185	COG1466	dna polymerase III delta subunit
EGY22_17190	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
EGY22_17215	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
EGY22_17225	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
EGY22_17230	COG0148	phosphopyruvate hydratase activity
EGY22_17240	COG2814	Major facilitator Superfamily
EGY22_17265	COG0504	CTP synthase activity
EGY22_17300	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EGY22_17310	COG0791	NLP P60 protein
EGY22_17320	COG0583	DNA-binding transcription factor activity
EGY22_17330	COG0583	DNA-binding transcription factor activity
EGY22_17340	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
EGY22_17355	COG1045	serine acetyltransferase
EGY22_17370	COG1381	Involved in DNA repair and RecF pathway recombination
EGY22_17375	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
EGY22_17380	COG0571	ribonuclease III activity
EGY22_17390	COG0481	GTPase activity
EGY22_17395	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EGY22_17420	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
EGY22_17430	COG1028	Short-chain dehydrogenase reductase Sdr
EGY22_17435	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
EGY22_17440	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EGY22_17445	COG0416	fatty acid biosynthetic process
EGY22_17450	COG0333	Belongs to the bacterial ribosomal protein bL32 family
EGY22_17455	COG1399	metal-binding, possibly nucleic acid-binding protein
EGY22_17460	COG0424	maF-like protein
EGY22_17470	COG3023	N-Acetylmuramoyl-L-alanine amidase
EGY22_17475	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
EGY22_17480	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
EGY22_17485	COG0546	phosphoglycolate phosphatase activity
EGY22_17490	COG0564	pseudouridine synthase activity
EGY22_17495	COG1530	ribonuclease E activity
EGY22_17500	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
EGY22_17505	COG0159	tryptophan synthase activity
EGY22_17510	COG0133	tryptophan synthase activity
EGY22_17515	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
EGY22_17525	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
EGY22_17530	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
EGY22_17540	COG2878	Part of a membrane complex involved in electron transport
EGY22_17545	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
EGY22_17550	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
EGY22_17555	COG3047	cAMP biosynthetic process
EGY22_17565	COG0411	ABC transporter
EGY22_17580	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EGY22_17585	COG2917	probably involved in intracellular septation
EGY22_17595	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EGY22_17600	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
EGY22_17610	COG1196	nuclear chromosome segregation
EGY22_17615	COG0477	Major facilitator Superfamily
EGY22_17620	COG1573	uracil-dna glycosylase
EGY22_17625	COG1214	PFAM Peptidase M22, glycoprotease
EGY22_17630	COG0745	RESPONSE REGULATOR receiver
EGY22_17635	COG2205	protein histidine kinase activity
EGY22_17645	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
EGY22_17650	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
EGY22_17655	COG0560	Phosphoserine phosphatase
EGY22_17670	COG1007	ATP synthesis coupled electron transport
EGY22_17685	COG0713	ATP synthesis coupled electron transport
EGY22_17695	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EGY22_17700	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
EGY22_17705	COG1034	ATP synthesis coupled electron transport
EGY22_17720	COG0649	NAD binding
EGY22_17725	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EGY22_17730	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EGY22_17735	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EGY22_17740	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
EGY22_17755	COG0149	triose-phosphate isomerase activity
EGY22_17760	COG0604	alcohol dehydrogenase
EGY22_17785	COG1185	polyribonucleotide nucleotidyltransferase activity
EGY22_17790	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
EGY22_17795	COG1183	phosphatidylcholine synthase activity
EGY22_17800	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
EGY22_17805	COG0440	acetolactate synthase activity
EGY22_17810	COG0028	Belongs to the TPP enzyme family
EGY22_17815	COG1289	transmembrane transporter activity
EGY22_17820	COG3022	response to hydroperoxide
EGY22_17825	COG1028	Short-chain dehydrogenase reductase Sdr
EGY22_17895	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
EGY22_17900	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
EGY22_17905	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
EGY22_17910	COG1674	ftsk spoiiie
EGY22_17915	COG0492	ferredoxin-NADP+ reductase activity
EGY22_17935	COG0477	Major facilitator Superfamily
EGY22_17955	COG2272	Belongs to the type-B carboxylesterase lipase family
EGY22_17960	COG1960	acyl-CoA dehydrogenase activity
EGY22_17985	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
EGY22_18005	COG2204	response regulator
EGY22_18045	COG4964	Belongs to the GSP D family
EGY22_18105	COG0612	Peptidase, M16
EGY22_18110	COG0484	heat shock protein binding
EGY22_18115	COG0443	Heat shock 70 kDa protein
EGY22_18120	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
EGY22_18125	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
EGY22_18130	COG1420	regulation of RNA biosynthetic process
EGY22_18135	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
EGY22_18140	COG0497	DNA recombination
EGY22_18145	COG0735	belongs to the Fur family
EGY22_18150	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EGY22_18155	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
EGY22_18170	COG2267	carboxylic ester hydrolase activity
EGY22_18180	COG0477	Major facilitator Superfamily
EGY22_18205	COG3122	Protein conserved in bacteria
EGY22_18215	COG3039	Transposase
EGY22_18225	COG0812	UDP-N-acetylmuramate dehydrogenase activity
EGY22_18255	COG1538	Outer membrane efflux protein
EGY22_18275	COG2271	Major facilitator Superfamily
EGY22_18295	COG2814	Major facilitator Superfamily
EGY22_18310	COG2819	hydrolase of the alpha beta superfamily
EGY22_18330	COG1454	alcohol dehydrogenase
EGY22_18340	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
EGY22_18350	COG0559	Belongs to the binding-protein-dependent transport system permease family
EGY22_18365	COG1414	Transcriptional regulator
EGY22_18370	COG0513	Belongs to the DEAD box helicase family
EGY22_18375	COG3657	addiction module killer protein
EGY22_18380	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
EGY22_18385	COG0583	DNA-binding transcription factor activity
EGY22_18390	COG4638	Rieske (2fe-2S)
EGY22_18395	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
EGY22_18410	COG0446	pyridine nucleotide-disulphide oxidoreductase
EGY22_18425	COG3971	2-oxopent-4-enoate hydratase activity
EGY22_18430	COG4569	acetaldehyde dehydrogenase (acetylating) activity
EGY22_18435	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
EGY22_18440	COG2814	Major facilitator Superfamily
EGY22_18455	COG0154	amidase activity
EGY22_18465	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EGY22_18470	COG2814	Major facilitator Superfamily
EGY22_18495	COG1028	Short-chain dehydrogenase reductase Sdr
EGY22_18505	COG0842	Transport permease protein
EGY22_18510	COG1129	ABC transporter
EGY22_18510	COG0842	Transport permease protein
EGY22_18515	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EGY22_18525	COG3243	poly(R)-hydroxyalkanoic acid synthase
EGY22_18535	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
EGY22_18540	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
EGY22_18545	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
EGY22_18560	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
EGY22_18575	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
EGY22_18580	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
EGY22_18590	COG0789	Transcriptional regulator
EGY22_18600	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EGY22_18645	COG3278	Belongs to the heme-copper respiratory oxidase family
EGY22_18650	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EGY22_18670	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
EGY22_18715	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
EGY22_18780	COG0516	GMP reductase activity
EGY22_18780	COG0517	IMP dehydrogenase activity
EGY22_18795	COG1027	Aspartate ammonia-lyase
EGY22_18800	COG1846	Transcriptional regulator
EGY22_18815	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
EGY22_18820	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
EGY22_18840	COG1414	Transcriptional regulator
EGY22_18860	COG0513	Belongs to the DEAD box helicase family
EGY22_18880	COG0429	hydrolase of the alpha beta-hydrolase fold
EGY22_18885	COG4783	chaperone-mediated protein folding