locus-tag class description D6I95_00015 ENOG4105CA0 peroxidase D6I95_00025 ENOG4105CG6 trap dicarboxylate transporter dctm subunit D6I95_00040 ENOG4105C85 amino acid D6I95_00045 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) D6I95_00075 ENOG4107S7U Sulfide dehydrogenase D6I95_00100 ENOG4105VEQ Cold shock protein D6I95_00105 ENOG4105DHQ Histidine kinase D6I95_00110 ENOG4105XJC Two component transcriptional regulator (Winged helix family D6I95_00115 ENOG4105EUH cytochrome C oxidase, cbb3-type, subunit i D6I95_00125 ENOG41090Y2 cytochrome C D6I95_00130 ENOG4105NQN cytochrome C D6I95_00135 ENOG4108R1E Serine threonine protein phosphatase 1 D6I95_00140 ENOG4105E0K tonB-dependent siderophore receptor D6I95_00180 ENOG4105J12 Multidrug resistance protein mdtN D6I95_00185 ENOG4105EM2 membrane D6I95_00190 ENOG4105C7N Xanthine uracil vitamin C permease D6I95_00195 ENOG41083B3 HAD-superfamily subfamily IB hydrolase D6I95_00220 ENOG4105CBC glutamate synthase D6I95_00230 ENOG4108SY4 MarR family Transcriptional regulator D6I95_00235 ENOG4105CEV competence damage-inducible protein D6I95_00240 ENOG4108I0Z Aconitate hydratase D6I95_00280 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr D6I95_00290 ENOG4107SG5 Dehydrogenase D6I95_00295 ENOG4105CHR reductase D6I95_00305 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) D6I95_00315 ENOG4105EGS Mechanosensitive ion channel D6I95_00320 ENOG4105EGS Mechanosensitive ion channel D6I95_00325 ENOG4108IMY Transcriptional regulator D6I95_00330 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase D6I95_00335 ENOG4105BZU Histidine kinase D6I95_00340 ENOG4105CJW magnesium transporter D6I95_00350 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) D6I95_00355 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) D6I95_00370 ENOG4108W0I acetyltransferase D6I95_00375 ENOG4105K5B UPF0225 protein D6I95_00380 ENOG4108K0D peptidase, M48 D6I95_00395 ENOG4105UPP uncharacterized protein ydcA D6I95_00495 ENOG4105KUS lysozyme D6I95_00540 ENOG4105BZU Histidine kinase D6I95_00555 ENOG4108XM1 transcriptional regulator AsnC family D6I95_00560 ENOG4105C28 cystathionine D6I95_00570 ENOG4105M6F mutator MutT protein D6I95_00575 ENOG4105WD1 Membrane D6I95_00585 ENOG4105CDH Citrulline--aspartate ligase D6I95_00595 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) D6I95_00605 ENOG4105DBV ornithine carbamoyltransferase D6I95_00615 ENOG4105C5I Dehydrogenase D6I95_00620 ENOG41082GY Binds directly to 16S ribosomal RNA (By similarity) D6I95_00625 ENOG4105CJR Integral membrane protein (MviN D6I95_00635 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) D6I95_00640 ENOG4105CET Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) D6I95_00645 ENOG4105W49 UPF0434 protein D6I95_00650 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) D6I95_00655 ENOG4105M8F Biopolymer transport protein exbD tolR D6I95_00665 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) D6I95_00670 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) D6I95_00675 ENOG4108UWD Iron-storage protein D6I95_00680 ENOG4105CHU acetyl-coa acetyltransferase D6I95_00690 ENOG4105VEQ Cold shock protein D6I95_00695 ENOG4105KAE Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) D6I95_00700 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit D6I95_00705 ENOG4105F1S paraquat-inducible protein a D6I95_00710 ENOG4105DY2 Paraquat-inducible protein b D6I95_00730 ENOG4105C32 Amino acid ABC transporter (Permease) D6I95_00735 ENOG4105CF8 branched-chain amino acid ABC transporter, permease D6I95_00740 ENOG4105C0Z ABC transporter D6I95_00745 ENOG4108IV0 ABC, transporter D6I95_00775 ENOG4105EBA Specifically methylates the adenine in position 1618 of 23S rRNA (By similarity) D6I95_00780 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) D6I95_00785 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase D6I95_00790 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) D6I95_00795 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) D6I95_00800 ENOG4105DTN riboflavin biosynthesis protein ribF D6I95_00805 ENOG4108V3E phosphoribosylglycinamide formyltransferase D6I95_00820 ENOG4105C4R Atp-dependent dna helicase D6I95_00845 ENOG4105C5H ABC transporter D6I95_00850 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) D6I95_00855 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) D6I95_00860 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) D6I95_00865 ENOG4105R1U AraC Family Transcriptional Regulator D6I95_00910 ENOG4108Z4X TRANSCRIPTIONal D6I95_00925 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F D6I95_00930 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation D6I95_00935 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) D6I95_00940 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) D6I95_00945 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) D6I95_00955 ENOG4108428 Inherit from COG: -acetyltransferase D6I95_00960 ENOG4105CGF Aromatic amino acid aminotransferase D6I95_00965 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) D6I95_00975 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family D6I95_00980 ENOG4105C3J Cysteine desulfurase D6I95_00985 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins D6I95_00990 ENOG4108Z4V iron-sulfur cluster assembly D6I95_01000 ENOG4105CRK lysyL-tRNA synthetase D6I95_01005 ENOG4105PDP Short chain dehydrogenase D6I95_01015 ENOG4105C8Q Methyl-accepting chemotaxis D6I95_01020 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) D6I95_01025 ENOG4108IPJ Membrane D6I95_01030 ENOG4105C09 Bile acid D6I95_01040 ENOG4105D5K Hemolysin activator protein D6I95_01045 ENOG4105CKT filamentous hemagglutinin D6I95_01115 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) D6I95_01130 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) D6I95_01135 ENOG4105EYA deoxyribonuclease D6I95_01140 ENOG4108EC8 DNA internalization-related competence protein ComEC D6I95_01145 ENOG4108EV1 Haloalkane dehalogenase D6I95_01150 ENOG4105DB7 PHP domain protein D6I95_01160 ENOG4108ETH Formylglycinamide ribotide synthetase D6I95_01165 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) D6I95_01175 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) D6I95_01180 ENOG4105DFP Integrase D6I95_01285 ENOG4105FA0 parb-like partition protein D6I95_01350 ENOG4107QJE Chromosome Partitioning Protein D6I95_01390 ENOG4105CNM Receptor D6I95_01395 ENOG4105R1U AraC Family Transcriptional Regulator D6I95_01400 ENOG4105DZ2 Transcriptional regulator D6I95_01430 ENOG4105CSU acyl-Coa dehydrogenase D6I95_01445 ENOG4105CMM transposase D6I95_01450 ENOG4105CKI cobalamin synthesis protein D6I95_01455 ENOG4105DZA Converts GTP to 7,8-dihydroneopterin triphosphate (By similarity) D6I95_01460 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) D6I95_01465 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) D6I95_01470 ENOG4105CD3 dihydroorotase D6I95_01475 ENOG41090R7 Ferric uptake D6I95_01480 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase D6I95_01490 ENOG4105E7U AraC family transcriptional regulator D6I95_01535 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) D6I95_01540 ENOG41090U3 tautomerase D6I95_01545 ENOG4108EGH Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) D6I95_01555 ENOG4105EA8 2-Nitropropane dioxygenase D6I95_01615 ENOG4108S10 Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) D6I95_01635 ENOG4105WPR Transcriptional regulator, ARAC family D6I95_01665 ENOG410846T CoA-transferase family III D6I95_01675 ENOG4105C1G acyl-Coa dehydrogenase D6I95_01700 ENOG41080HT Transcriptional regulator, arsr family D6I95_01750 ENOG410626B catechol 1,2-dioxygenase D6I95_01760 ENOG4107QNJ CoA-transferase subunit B D6I95_01765 ENOG4105F2Z 3-oxoadipate enol-lactonase D6I95_01775 ENOG4105DKK Benzoate D6I95_01780 ENOG4108MR5 D6I95_01785 ENOG4108MZY D6I95_01795 ENOG4108IUW ABC transporter D6I95_01805 ENOG4105WH1 Two component transcriptional regulator luxr family D6I95_01835 ENOG4108VHT MarR family transcriptional regulator D6I95_01840 ENOG4105MSY salicylate hydroxylase D6I95_01845 ENOG4105CSP Major Facilitator Superfamily D6I95_01855 ENOG4105DFA alanine racemase domain protein D6I95_01860 ENOG4105CSW GntR family transcriptional regulator D6I95_01865 ENOG4108KTG Membrane protein, drug metabolite transporter D6I95_01875 ENOG4105F2V VRR-NUC domain-containing protein D6I95_01895 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) D6I95_01900 ENOG4105CPC Aldo Keto reductase D6I95_01915 ENOG4108UT2 hemolysin iii D6I95_01930 ENOG4105CSH Transporter D6I95_01935 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) D6I95_01960 ENOG4105EAB amino acid AbC transporter D6I95_01965 ENOG4105E5Q amino acid AbC transporter D6I95_01970 ENOG4105DRP amino acid AbC transporter D6I95_01975 ENOG4105CDA abc transporter atp-binding protein D6I95_02005 ENOG4105EUV Phenol 2-monooxygenase D6I95_02025 ENOG4108JA0 Oxidoreductase, FAD NAD(P)-binding domain protein D6I95_02060 ENOG4105D2S major facilitator superfamily D6I95_02070 ENOG410829K Lysine exporter protein (Lyse ygga) D6I95_02085 ENOG4107QX8 SPFH domain, Band 7 family protein D6I95_02090 ENOG4105G5H Membrane D6I95_02100 ENOG4105UCG Domain of unknown function (DUF333) D6I95_02110 ENOG4108MGF sugar kinase D6I95_02125 ENOG4105C22 threonyL-tRNA synthetase D6I95_02130 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) D6I95_02135 ENOG4105D7Z glutathione synthase D6I95_02145 ENOG41080Z8 PHOSPHOCARRIER protein D6I95_02150 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) D6I95_02175 ENOG4105C0P Mg chelatase subunit ChlI D6I95_02190 ENOG4105VJV 50s ribosomal protein L35 D6I95_02195 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) D6I95_02200 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) D6I95_02205 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) D6I95_02210 ENOG4108ZUF This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) D6I95_02220 ENOG4105ED9 Protein of unknown function (DUF455) D6I95_02230 ENOG4108JJ7 ABC transporter D6I95_02235 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family D6I95_02245 ENOG4105C3K feS assembly ATPase SufC D6I95_02250 ENOG4105JRK feS assembly protein SufD D6I95_02255 ENOG4105C9B Cysteine desulfurase D6I95_02260 ENOG4108UNV SUF system FeS assembly protein, NifU family D6I95_02265 ENOG4105VG1 fes assembly suf system protein D6I95_02270 ENOG4105HX0 Transcriptional regulator D6I95_02275 ENOG4107RCH Diaminopropionate ammonia-lyase D6I95_02280 ENOG4105CE7 Amidase, hydantoinase carbamoylase family D6I95_02300 ENOG4108JQ6 ABC transporter D6I95_02310 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) D6I95_02340 ENOG4105VEQ Cold shock protein D6I95_02405 ENOG4105FC8 fad dependent oxidoreductase D6I95_02410 ENOG4108K88 Membrane D6I95_02420 ENOG4105E6M Sulphatase-modifying factor protein D6I95_02435 ENOG4105CZN Potassium uptake protein D6I95_02445 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase D6I95_02455 ENOG4105KTH gatB Yqey D6I95_02460 ENOG4105C0B DNA polymerase III (alpha subunit) D6I95_02500 ENOG4105DUM transcriptional regulator, lysR family D6I95_02505 ENOG41061WM D-Alanyl-D-Alanine D6I95_02515 ENOG4107R0U MotA TolQ exbB proton channel D6I95_02520 ENOG4106VK6 Flagellar motor protein D6I95_02530 ENOG4105CHR reductase D6I95_02535 ENOG4105CPU Monooxygenase D6I95_02540 ENOG4105EMU Dehydrogenase D6I95_02545 ENOG4108R6K riboflavin synthase, subunit alpha D6I95_02555 ENOG4108IJ0 Aspartate ammonia-lyase D6I95_02560 ENOG4105CK2 sodium dicarboxylate symporter D6I95_02570 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family D6I95_02575 ENOG4106P55 Transcriptional regulator D6I95_02580 ENOG4107EFR Flavocytochrome c D6I95_02585 ENOG41079YP Citrate utilization protein b D6I95_02595 ENOG4105DB1 molybdopterin oxidoreductase D6I95_02600 ENOG4106WHD Tetrathionate reductase D6I95_02605 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein D6I95_02610 ENOG4107RNH Outer membrane receptor FepA D6I95_02625 ENOG4107Y70 Heat shock protein D6I95_02665 ENOG41090MY MarR family Transcriptional regulator D6I95_02670 ENOG4105E09 nadh pyrophosphatase D6I95_02680 ENOG4105DSJ YicC domain protein D6I95_02685 ENOG4107RFY SbcCD D subunit D6I95_02695 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) D6I95_02700 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) D6I95_02705 ENOG4105CSA Coproporphyrinogen iii oxidase D6I95_02710 ENOG4105C5F glutamine synthetase D6I95_02715 ENOG4107YB6 acetyltransferase, (GNAT) family D6I95_02735 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) D6I95_02740 ENOG4107Z6A sulfate abc transporter permease D6I95_02750 ENOG4105DP0 ferredoxin-NADP reductase D6I95_02755 ENOG4105KME endoribonuclease L-psp D6I95_02760 ENOG4105CB5 ATP-dependent DNA helicase recG D6I95_02775 ENOG4105CP9 extracellular ligand-binding receptor D6I95_02780 ENOG4108IJ9 (ABC) transporter D6I95_02795 ENOG4105BZ7 extracellular solute-binding protein family 1 D6I95_02800 ENOG4105II7 pyrroline-5-carboxylate reductase D6I95_02805 ENOG4105CP9 extracellular ligand-binding receptor D6I95_02810 ENOG4105C32 Amino acid ABC transporter (Permease) D6I95_02815 ENOG4105CF8 branched-chain amino acid ABC transporter, permease D6I95_02820 ENOG4105C0Z ABC transporter D6I95_02825 ENOG4108IV0 ABC, transporter D6I95_02835 ENOG4108K3A Glutathione S-transferase D6I95_02845 ENOG4105C5I Dehydrogenase D6I95_02850 ENOG4105CHR reductase D6I95_02855 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase D6I95_02860 ENOG4105C9Q fumarate hydratase class II D6I95_02865 ENOG4105D8V Glucose sorbosone dehydrogenase D6I95_02870 ENOG4107YZX Universal stress protein D6I95_02875 ENOG4105W2Z cytochrome C, class I D6I95_02880 ENOG4105DJ2 Major Facilitator Superfamily D6I95_02890 ENOG4105EJC lysr family transcriptional regulator D6I95_02905 ENOG4108V0E nucleoside 2-deoxyribosyltransferase YtoQ D6I95_02910 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) D6I95_02920 ENOG4108EF9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR D6I95_02930 ENOG4105CSR polyphosphate kinase 2 D6I95_03095 ENOG4105T95 Thiol disulfide interChange protein D6I95_03135 ENOG4105KT5 UmuD protein D6I95_03140 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) D6I95_03175 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) D6I95_03180 ENOG4105C4R Atp-dependent dna helicase D6I95_03210 ENOG4108YGG dna repair protein D6I95_03275 ENOG4105C0D helicase D6I95_03320 ENOG4107U53 septum site-determining protein minD D6I95_03340 ENOG4107ENK receptor D6I95_03350 ENOG4105CA0 peroxidase D6I95_03385 ENOG4105E0K tonB-dependent siderophore receptor D6I95_03450 ENOG4105EWC Purine nucleoside phosphorylase D6I95_03500 ENOG4108JQ7 (ABC) transporter D6I95_03505 ENOG4105C3U ABC transporter D6I95_03510 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component D6I95_03515 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component D6I95_03520 ENOG4105DEF Extracellular solute-binding protein, family 5 D6I95_03525 ENOG4105EGI Transcriptional regulator D6I95_03550 ENOG4105DS1 cytochrome b561 D6I95_03560 ENOG4108YYC ycei family D6I95_03565 ENOG4105K89 arsenate reductase D6I95_03570 ENOG4105CYM Glutathione S-transferase D6I95_03585 ENOG4105F8V Hydrolase, tatD family D6I95_03590 ENOG4107QRG dna polymerase iii D6I95_03600 ENOG4105HHA aminodeoxychorismate lyase D6I95_03605 ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) D6I95_03610 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase D6I95_03620 ENOG4105C1G acyl-Coa dehydrogenase D6I95_03625 ENOG4105VDB UPF0125 protein D6I95_03630 ENOG4108Z1B Cyclase dehydrase D6I95_03635 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) D6I95_03640 ENOG4105CEP NADH dehydrogenase D6I95_03650 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) D6I95_03655 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) D6I95_03665 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) D6I95_03670 ENOG4105D0V Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) D6I95_03680 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) D6I95_03685 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) D6I95_03695 ENOG4105E1Z Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane D6I95_03700 ENOG4105DZP Membrane-associated zinc metalloprotease D6I95_03705 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) D6I95_03710 ENOG4105KNE Phosphatidate cytidylyltransferase D6I95_03715 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) D6I95_03720 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) D6I95_03725 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) D6I95_03730 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) D6I95_03735 ENOG4105CE9 30S ribosomal protein S2 D6I95_03740 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) D6I95_03745 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) D6I95_03765 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase D6I95_03770 ENOG4105E96 Colicin v production protein D6I95_03780 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase D6I95_03785 ENOG4107QN2 dihydrolipoyl dehydrogenase D6I95_03790 ENOG4107QSN dihydrolipoamide acetyltransferase D6I95_03795 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) D6I95_03800 ENOG4105BZU Histidine kinase D6I95_03810 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) D6I95_03815 ENOG4105DGW oligopeptidase A D6I95_03825 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) D6I95_03835 ENOG4105YVS arsR family transcriptional regulator D6I95_03845 ENOG4108Z6Z Transcriptional regulator D6I95_03850 ENOG4105CG6 trap dicarboxylate transporter dctm subunit D6I95_03855 ENOG4105XDZ Tripartite ATP-independent periplasmic transporter D6I95_03860 ENOG4105GQU Trap dicarboxylate transporter, dctp subunit D6I95_03865 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) D6I95_03870 ENOG4105CHR reductase D6I95_03915 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) D6I95_03920 ENOG4105ENJ RND efflux system, outer membrane lipoprotein D6I95_03925 ENOG4105BZS acriflavin resistance protein D6I95_03930 ENOG4105C1P efflux transporter, rnd family, mfp subunit D6I95_03955 ENOG4105CHU acetyl-coa acetyltransferase D6I95_03965 ENOG4105EMY transcriptional regulator D6I95_03970 ENOG4105CXN decarboxylase D6I95_03995 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) D6I95_04000 ENOG4105VFG Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) D6I95_04005 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) D6I95_04015 ENOG4108UMN azlc family D6I95_04020 ENOG4105DR5 peptidase D6I95_04025 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) D6I95_04030 ENOG4107T6V glycerophosphoryl diester phosphodiesterase D6I95_04035 ENOG4105D6S protein involved in catabolism of external DNA D6I95_04040 ENOG4105FE9 pseudouridine synthase D6I95_04045 ENOG4105RUM Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4- hydroxybenzoate (4HB) for the ubiquinone pathway (By similarity) D6I95_04050 ENOG4105DXI Major Facilitator superfamily D6I95_04055 ENOG4105CV8 reductase D6I95_04060 ENOG4108YZA Nitrogen regulatory protein pii D6I95_04065 ENOG4105CUY Mechanosensitive ion channel D6I95_04070 ENOG4105CH7 arginosuccinase D6I95_04075 ENOG4105CJP fad dependent oxidoreductase D6I95_04085 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) D6I95_04090 ENOG4108K5P (LipO)protein D6I95_04095 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) D6I95_04100 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) D6I95_04105 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) D6I95_04110 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) D6I95_04115 ENOG4105C7N Xanthine uracil vitamin C permease D6I95_04120 ENOG41080RH Thioredoxin D6I95_04140 ENOG4105C5H ABC transporter D6I95_04145 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A D6I95_04150 ENOG4108Z6B deaminase D6I95_04155 ENOG4105DA5 (ABC) transporter D6I95_04160 ENOG4105E3A (ABC) transporter D6I95_04190 ENOG4108VPT UPF0234 protein D6I95_04195 ENOG4105CEY Amp-dependent synthetase and ligase D6I95_04200 ENOG4107Z6W Protein CrcB homolog D6I95_04205 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) D6I95_04210 ENOG41075H3 AraC family transcriptional regulator D6I95_04215 ENOG4105DHU Bile acid D6I95_04225 ENOG4107ZT5 Thiol disulfide interchange protein D6I95_04230 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase D6I95_04235 ENOG4105CG6 trap dicarboxylate transporter dctm subunit D6I95_04245 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) D6I95_04255 ENOG4107QJH Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) D6I95_04260 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) D6I95_04265 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) D6I95_04270 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) D6I95_04275 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) D6I95_04285 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase D6I95_04290 ENOG4105CNG UPF0061 protein D6I95_04300 ENOG4107S2Z UPF0761 membrane protein D6I95_04310 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) D6I95_04380 ENOG4108S3W Anti-feci sigma factor, fecr D6I95_04385 ENOG4108SF5 RNA Polymerase D6I95_04395 ENOG4105F0N pyrophosphate phospho-hydrolase D6I95_04405 ENOG4105ECF c-methyltransferase D6I95_04415 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) D6I95_04420 ENOG4108ZCF integral membrane protein D6I95_04425 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha D6I95_04430 ENOG4105CMV Succinyl-CoA synthetase subunit beta D6I95_04440 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) D6I95_04445 ENOG4105DZ2 Transcriptional regulator D6I95_04450 ENOG4108004 Modulates RecA activity (By similarity) D6I95_04470 ENOG4105CSH Transporter D6I95_04485 ENOG4105CEY Amp-dependent synthetase and ligase D6I95_04490 ENOG4105E9F Enoyl-CoA hydratase D6I95_04495 ENOG41062QD Membrane D6I95_04500 ENOG4107QN1 sodium solute D6I95_04505 ENOG4105C26 Dehydrogenase D6I95_04510 ENOG4105CXT aspartate transcarbamylase D6I95_04525 ENOG4105BZ4 penicillin-binding protein D6I95_04530 ENOG4107S52 alpha-2-macroglobulin domain protein D6I95_04540 ENOG4105EA8 2-Nitropropane dioxygenase D6I95_04545 ENOG4105D4P Coproporphyrinogen iii oxidase D6I95_04550 ENOG4105D65 subunit l D6I95_04555 ENOG4108ZE9 Monovalent cation H antiporter subunit C D6I95_04560 ENOG4107R4Z monovalent cation h antiporter subunit d D6I95_04570 ENOG4105W4C monovalent cation H antiporter subunit F D6I95_04575 ENOG4105KJM monovalent cation h antiporter subunit g D6I95_04585 ENOG4105DFH Transport of potassium into the cell (By similarity) D6I95_04590 ENOG4105DHQ Histidine kinase D6I95_04615 ENOG4108IJ6 ABC transporter D6I95_04620 ENOG4105ECW sulfate abc transporter D6I95_04625 ENOG4108I5D sulfate abc transporter D6I95_04630 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein D6I95_04640 ENOG4105VEQ Cold shock protein D6I95_04665 ENOG4105K70 DNA-binding protein D6I95_04670 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) D6I95_04680 ENOG4106P6N cytochrome d1 heme region D6I95_04685 ENOG4108UMR transcriptional regulator AsnC family D6I95_04690 ENOG4108ZGY Transcriptional regulator (AsnC family) D6I95_04695 ENOG4108UMR transcriptional regulator AsnC family D6I95_04700 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) D6I95_04705 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) D6I95_04720 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family D6I95_04725 ENOG4105C28 cystathionine D6I95_04730 ENOG4105C2N RNA methyltransferase TrmH family group 3 D6I95_04735 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) D6I95_04760 ENOG4105Q26 Siderophore-interacting protein D6I95_04780 ENOG4105EHH Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue (By similarity) D6I95_04790 ENOG4105DUM transcriptional regulator, lysR family D6I95_04795 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) D6I95_04805 ENOG4108KAZ Involved in phosphonate degradation (By similarity) D6I95_04810 ENOG4105C4Y ABC transporter D6I95_04820 ENOG4108Z7F N-acetyltransferase D6I95_04830 ENOG4105DJ2 Major Facilitator Superfamily D6I95_04845 ENOG4107Y1Y Methyltransferase D6I95_04850 ENOG4107ZSV Receptor D6I95_04870 ENOG4105CDZ Carboxymethylenebutenolidase (EC 3.1.1.45) D6I95_04875 ENOG4105VRT cytoplasmic protein D6I95_04880 ENOG4105CYM Glutathione S-transferase D6I95_04890 ENOG4105EUB pirin domain protein D6I95_04900 ENOG4107QPI nitrilase cyanide hydratase and apolipoprotein n-acyltransferase D6I95_04905 ENOG4105F27 Major Facilitator D6I95_04910 ENOG4105DJ2 Major Facilitator Superfamily D6I95_04915 ENOG4105R1U AraC Family Transcriptional Regulator D6I95_04920 ENOG4105DKK Benzoate D6I95_04930 ENOG4105E7W lamb ycsf family protein D6I95_04945 ENOG4105C7W Xanthine dehydrogenase D6I95_04955 ENOG4107QUY Guanine deaminase D6I95_04965 ENOG4105XJC Two component transcriptional regulator (Winged helix family D6I95_04975 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) D6I95_04980 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) D6I95_04985 ENOG4105VCC 30S ribosomal protein S21 D6I95_04990 ENOG4105DYA Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity) D6I95_04995 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis D6I95_05000 ENOG4105C49 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity) D6I95_05005 ENOG4105EPW hflc protein D6I95_05010 ENOG4107QJR hflk protein D6I95_05015 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) D6I95_05020 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) D6I95_05025 ENOG4105CIH Imidazole acetol-phosphate transaminase D6I95_05030 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) D6I95_05035 ENOG4105CNE Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) D6I95_05040 ENOG4105N21 Membrane D6I95_05045 ENOG4105CUT histidyl-tRNA synthetase D6I95_05050 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) D6I95_05060 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs D6I95_05065 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) D6I95_05075 ENOG4108HWB Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) D6I95_05080 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) D6I95_05085 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) D6I95_05090 ENOG4105K5M 30s ribosomal protein S16 D6I95_05095 ENOG41082K8 Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity) D6I95_05100 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) D6I95_05140 ENOG4105BZ7 extracellular solute-binding protein family 1 D6I95_05145 ENOG4105MWK D-amino acid dehydrogenase, small subunit D6I95_05155 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) D6I95_05160 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) D6I95_05165 ENOG4105K63 Thioredoxin D6I95_05170 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) D6I95_05175 ENOG4105D82 Glutamate dehydrogenase D6I95_05190 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) D6I95_05195 ENOG4105WPN DNA integration recombination invertion protein D6I95_05200 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit D6I95_05205 ENOG4105DS0 Transcriptional regulator, Crp Fnr family D6I95_05220 ENOG4105C58 cytochrome c oxidase accessory protein ccog D6I95_05240 ENOG4105EUH cytochrome C oxidase, cbb3-type, subunit i D6I95_05250 ENOG4105C59 p-type ATPase D6I95_05260 ENOG4105CSD Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) D6I95_05275 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) D6I95_05280 ENOG4107QPA Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides (By similarity) D6I95_05285 ENOG4105KJV Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) D6I95_05295 ENOG4108ZJI phenylacetic acid degradation protein D6I95_05300 ENOG4108UKI Enoyl-CoA hydratase D6I95_05305 ENOG4105C26 Dehydrogenase D6I95_05310 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) D6I95_05315 ENOG4108ZA2 phenylacetate-CoA oxygenase PaaJ subunit D6I95_05320 ENOG4105D9S phenylacetate-CoA oxygenase PaaI subunit D6I95_05325 ENOG4105N76 Phenylacetate-CoA oxygenase, subunit D6I95_05330 ENOG4105CRS phenylacetate-CoA oxygenase PaaG subunit D6I95_05335 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) D6I95_05340 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 D6I95_05345 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) D6I95_05355 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) D6I95_05375 ENOG4105D3R alkyl hydroperoxide reductase D6I95_05380 ENOG4105CSU acyl-Coa dehydrogenase D6I95_05385 ENOG4105C10 Electron transfer flavoprotein D6I95_05390 ENOG4105BZJ Electron transfer flavoprotein D6I95_05395 ENOG4105DGU Histone deacetylase D6I95_05400 ENOG4105CVE Lytic murein transglycosylase D6I95_05405 ENOG4105C6T cysteine synthase D6I95_05410 ENOG4105C0B DNA polymerase III (alpha subunit) D6I95_05415 ENOG4105CUI Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity) D6I95_05420 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) D6I95_05425 ENOG4105CFV Tetratricopeptide repeat protein D6I95_05440 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) D6I95_05445 ENOG4105CAT Cytidine monophosphate kinase D6I95_05450 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase D6I95_05455 ENOG4105EVN Prephenate dehydrogenase D6I95_05460 ENOG4105CQC Prephenate dehydratase D6I95_05465 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) D6I95_05470 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) D6I95_05475 ENOG4105UYK outer membrane protein a D6I95_05480 ENOG4108HWB Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) D6I95_05485 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) D6I95_05490 ENOG4105DUM transcriptional regulator, lysR family D6I95_05500 ENOG4108Z4U Ferredoxin D6I95_05520 ENOG4105F1N DNA alkylation repair D6I95_05525 ENOG41082F9 transcriptional regulator D6I95_05530 ENOG4105CHM Aminotransferase D6I95_05535 ENOG4108IG5 Transcriptional regulator D6I95_05560 ENOG4108K3A Glutathione S-transferase D6I95_05635 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) D6I95_05645 ENOG4107QV7 Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) (By similarity) D6I95_05670 ENOG4107QN1 sodium solute D6I95_05680 ENOG4105BZU Histidine kinase D6I95_05685 ENOG4107RIQ Sulfate adenylate transferase D6I95_05690 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) D6I95_05705 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor D6I95_05720 ENOG4105EXG Transcriptional regulator D6I95_05725 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) D6I95_05730 ENOG4107T1C Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity) D6I95_05745 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) D6I95_05750 ENOG4105CGZ zinc metallopeptidase D6I95_05760 ENOG4108YZA Nitrogen regulatory protein pii D6I95_05765 ENOG4105BZU Histidine kinase D6I95_05770 ENOG4105T86 cytochrome C D6I95_05775 ENOG4107QTF adenylosuccinate lyase D6I95_05780 ENOG4108U78 Glutathione S-transferase D6I95_05785 ENOG4105HF0 Membrane D6I95_05790 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) D6I95_05795 ENOG4105CQB FAD linked oxidase domain protein D6I95_05800 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) D6I95_05805 ENOG4105VCD cytoplasmic protein D6I95_05810 ENOG4105D22 carbon starvation protein D6I95_05840 ENOG4105EV8 ectoine hydroxylase D6I95_05845 ENOG4108Z6K Catalyzes the circularization of gamma-N-acetyl- alpha,gamma-diaminobutyric acid (ADABA) to ectoine (1,4,5,6- tetrahydro-2-methyl-4-pyrimidine carboxylic acid), which is an excellent osmoprotectant (By similarity) D6I95_05850 ENOG4108JPW Aminotransferase D6I95_05855 ENOG4108Z24 l-2,4-diaminobutyric acid acetyltransferase D6I95_05860 ENOG41090MY MarR family Transcriptional regulator D6I95_05870 ENOG4105D1U peptidase U62 modulator of DNA gyrase D6I95_05875 ENOG4105VFQ Histone family protein nucleoid-structuring protein H-NS D6I95_05885 ENOG4105CD8 aminopeptidase N D6I95_05890 ENOG4105CZI D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 D6I95_05895 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein D6I95_05915 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) D6I95_05925 ENOG4105D7A ATP-binding protein D6I95_05930 ENOG4105CDY transcriptional regulatory protein D6I95_05935 ENOG4105C12 Phosphoribosylglycinamide synthetase D6I95_05940 ENOG4105DBS Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity) D6I95_05945 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) D6I95_05950 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) D6I95_05955 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) D6I95_05960 ENOG4108Z03 MAF-like protein D6I95_05965 ENOG4108KHN disulfide isomerase, thiol-disulfide oxidase D6I95_05980 ENOG4108ZJT translation initiation factor, Sui1 D6I95_05990 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase D6I95_05995 ENOG4108RXX maleylacetoacetate isomerase D6I95_06000 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) D6I95_06005 ENOG4108YZY peptidylprolyl cis-trans isomerase D6I95_06010 ENOG4105W5Q DNA repair protein (RadC D6I95_06015 ENOG4105NRA 50s ribosomal protein l31 type b D6I95_06025 ENOG4107QI1 Mate efflux family protein D6I95_06030 ENOG4108IJ7 Glycine betaine D6I95_06035 ENOG4108HQS Glycine betaine D6I95_06045 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase D6I95_06050 ENOG4105C2C drug resistance transporter, Bcr CflA D6I95_06055 ENOG4105KDC 50s ribosomal protein l28 D6I95_06060 ENOG4105W0E 50S ribosomal protein L33 D6I95_06075 ENOG4105C8T Leucyl-tRNA synthetase D6I95_06085 ENOG4105DJF DNA polymerase III, delta' subunit D6I95_06090 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) D6I95_06110 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) D6I95_06120 ENOG4105XX3 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) D6I95_06125 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) D6I95_06155 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) D6I95_06180 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase D6I95_06185 ENOG4108594 Permease of the drug metabolite transporter D6I95_06190 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) D6I95_06200 ENOG4105K4H Nlp p60 protein D6I95_06210 ENOG4107R11 Transcriptional regulator D6I95_06215 ENOG4105C26 Dehydrogenase D6I95_06220 ENOG4105SKE transcriptional Regulator LysR family D6I95_06225 ENOG4105E0K tonB-dependent siderophore receptor D6I95_06235 ENOG4105EHG Permease protein D6I95_06245 ENOG4105CPU Monooxygenase D6I95_06250 ENOG4108WUH Transcriptional regulator, TetR family D6I95_06260 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) D6I95_06270 ENOG4108XRP Membrane D6I95_06275 ENOG4105D7W serine acetyltransferase D6I95_06290 ENOG41071DT Involved in DNA repair and RecF pathway recombination (By similarity) D6I95_06295 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) D6I95_06300 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) D6I95_06305 ENOG4105C3F Signal peptidase i D6I95_06310 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) D6I95_06315 ENOG4105C0H protease D6I95_06330 ENOG4105EMN RNA polymerase sigma factor D6I95_06340 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) D6I95_06350 ENOG4105CHR reductase D6I95_06355 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase D6I95_06360 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) D6I95_06365 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) D6I95_06370 ENOG4105VGS 50s ribosomal protein l32 D6I95_06375 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein D6I95_06380 ENOG4108UHJ MAF-like protein D6I95_06385 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) D6I95_06390 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase D6I95_06395 ENOG4105DQ2 Is probably involved in the electron transfer between its heme and the molybdenum cofactor of the reductase catalytic subunit YedY (By similarity) D6I95_06400 ENOG4105CCD The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity) D6I95_06405 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) D6I95_06410 ENOG4105EI2 Pseudouridine synthase D6I95_06415 ENOG4105C03 ribonuclease D6I95_06420 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) D6I95_06425 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) D6I95_06430 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) D6I95_06435 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) D6I95_06445 ENOG4107RH7 Nicotinate phosphoribosyltransferase D6I95_06450 ENOG4108Z4U Ferredoxin D6I95_06460 ENOG4108R3D Electron transport complex D6I95_06465 ENOG4105CSM endonuclease III D6I95_06470 ENOG4108JJ8 (ABC) transporter D6I95_06475 ENOG4105EIF outer membrane protein W D6I95_06480 ENOG4108IV0 ABC, transporter D6I95_06485 ENOG4105C0Z ABC transporter D6I95_06500 ENOG4105E0X reductase D6I95_06505 ENOG4107835 probably involved in intracellular septation (By similarity) D6I95_06515 ENOG4107TF3 peptidylprolyl cis-trans isomerase D6I95_06520 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) D6I95_06530 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) D6I95_06540 ENOG4108UN4 phage SPO1 DNA polymerase-related protein D6I95_06545 ENOG41072GX Peptidase M22 Glycoprotease D6I95_06550 ENOG4105DPZ Two component transcriptional regulator (Winged helix family D6I95_06555 ENOG4105E0F Histidine kinase D6I95_06565 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) D6I95_06570 ENOG4108JA2 transcriptioN-repair coupling factor D6I95_06580 ENOG4105EAC phosphoserine phosphatase D6I95_06585 ENOG4107QWG 2-Nitropropane dioxygenase D6I95_06595 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) D6I95_06600 ENOG4105C8S subunit m D6I95_06610 ENOG4105M5H NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) D6I95_06615 ENOG4105DF2 NADH dehydrogenase subunit j D6I95_06620 ENOG4105P3U NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) D6I95_06625 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) D6I95_06630 ENOG4108IEH NADH dehydrogenase subunit g D6I95_06645 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) D6I95_06650 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain D6I95_06655 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) D6I95_06660 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain D6I95_06665 ENOG4108Z9W Outer membrane porin D6I95_06675 ENOG4107EJC Preprotein translocase subunit SecG D6I95_06680 ENOG4105CP7 Triose-phosphate isomerase D6I95_06685 ENOG4105CB2 alcohol dehydrogenase D6I95_06710 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) D6I95_06715 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase D6I95_06720 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase D6I95_06725 ENOG4108ZP8 Acetolactate synthase small subunit D6I95_06730 ENOG4105C7K acetolactate synthase D6I95_06740 ENOG4105D1Q UPF0246 protein D6I95_06760 ENOG4106FGB Beta-lactamase D6I95_06775 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) D6I95_06790 ENOG4107QMH DNA methylase D6I95_06795 ENOG4105D1H recombination factor protein RarA D6I95_06800 ENOG4107Y7W Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity) D6I95_06805 ENOG4105CNU cell division protein FtsK D6I95_06810 ENOG4105C3M thioredoxin reductase D6I95_06820 ENOG4105WAP TPR repeat-containing protein D6I95_06850 ENOG4105EBR Carboxylesterase D6I95_06855 ENOG4108KC1 acyl-Coa dehydrogenase D6I95_06875 ENOG4106RE7 Cytochrome D6I95_06880 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) D6I95_06900 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family D6I95_07000 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) D6I95_07005 ENOG4105CFG Acts as a chaperone (By similarity) D6I95_07010 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ D6I95_07020 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) D6I95_07025 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) D6I95_07030 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) D6I95_07035 ENOG41090R7 Ferric uptake D6I95_07040 ENOG4105YRI Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) D6I95_07045 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) D6I95_07055 ENOG4105D4A Cell wall formation (By similarity) D6I95_07075 ENOG4105BZU Histidine kinase D6I95_07085 ENOG4105CNM Receptor D6I95_07090 ENOG4105CBK multidrug resistance protein D6I95_07100 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) D6I95_07105 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein D6I95_07110 ENOG4108MG3 formate dehydrogenase D6I95_07115 ENOG4105F46 Necessary for formate dehydrogenase activity (By similarity) D6I95_07120 ENOG4105NIV Esterase D6I95_07140 ENOG4105C0A alcohol dehydrogenase D6I95_07145 ENOG4108IV0 ABC, transporter D6I95_07150 ENOG4108IUZ ABC transporter D6I95_07160 ENOG4105C32 Amino acid ABC transporter (Permease) D6I95_07170 ENOG4105C26 Dehydrogenase D6I95_07175 ENOG4108FUF Transcriptional regulator, IclR family D6I95_07185 ENOG4105C1J atp-dependent rna helicase D6I95_07195 ENOG4105YES addiction module antidote protein D6I95_07200 ENOG4108W5M transcriptional regulator D6I95_07205 ENOG4105FUY alpha subunit D6I95_07210 ENOG4108SBK dioxygenase, subunit beta D6I95_07225 ENOG4108DNI pyridine nucleotide-disulfide oxidoreductase D6I95_07235 ENOG4107UB2 Alpha beta hydrolase fold D6I95_07245 ENOG4105DIV Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD( ) and coenzyme A. Is the final enzyme in the meta- cleavage pathway for the degradation of aromatic compounds (By similarity) D6I95_07250 ENOG4105DF3 Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta-cleavage pathway for the degradation of aromatic compounds (By similarity) D6I95_07255 ENOG4108SC4 )-transporter D6I95_07270 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) D6I95_07275 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family D6I95_07280 ENOG4105DXI Major Facilitator superfamily D6I95_07290 ENOG4105CHU acetyl-coa acetyltransferase D6I95_07295 ENOG4105CHR reductase D6I95_07305 ENOG4105CMI transporter D6I95_07310 ENOG4105CJ1 ABC, transporter D6I95_07315 ENOG4105D0S secretion protein (HlyD D6I95_07320 ENOG4105ENJ RND efflux system, outer membrane lipoprotein D6I95_07325 ENOG4105D1N poly(r)-hydroxyalkanoic acid synthase, class D6I95_07335 ENOG4105EX9 Membrane D6I95_07340 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) D6I95_07345 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) D6I95_07360 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) D6I95_07370 ENOG4105XPH Ferredoxin D6I95_07375 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain D6I95_07390 ENOG4108Z4X TRANSCRIPTIONal D6I95_07400 ENOG4105BZS acriflavin resistance protein D6I95_07415 ENOG4107TSX ABC branched chain amino acid family transporter periplasmic ligand binding protein D6I95_07420 ENOG4105IW1 AmiS UreI transporter D6I95_07430 ENOG4105EVZ LysR family transcriptional regulator D6I95_07435 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) D6I95_07440 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) D6I95_07455 ENOG4105HSS phospholipase C D6I95_07460 ENOG4105D7Q type ii secretion system D6I95_07465 ENOG4107QHF type ii secretion system protein e D6I95_07470 ENOG4105GVR general secretion pathway protein D D6I95_07495 ENOG4108WWZ General secretion pathway protein J D6I95_07510 ENOG4108VAU general secretion pathway protein G D6I95_07520 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) D6I95_07535 ENOG4108IJ0 Aspartate ammonia-lyase D6I95_07540 ENOG41082F9 transcriptional regulator D6I95_07550 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) D6I95_07560 ENOG4105DWA May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate D6I95_07575 ENOG41069M3 Transcriptional regulator D6I95_07595 ENOG4105C1J atp-dependent rna helicase D6I95_07615 ENOG4105DNZ Alpha Beta Hydrolase D6I95_07620 ENOG4105ERG peptidase m48, ste24p D6I95_07640 ENOG4105D0A hydroxylase D6I95_07645 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) D6I95_07650 ENOG4105VY0 Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters (By similarity) D6I95_07660 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) D6I95_07665 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) D6I95_07675 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) D6I95_07685 ENOG4105EKE dihydroorotase D6I95_07695 ENOG4105CVP deoxyribo-dipyrimidine photolyase D6I95_07745 ENOG4105KHC sulfurtransferase D6I95_07750 ENOG41066VF YeeE YedE family protein D6I95_07760 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) D6I95_07800 ENOG4105D38 putrescine abc transporter D6I95_07805 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) D6I95_07810 ENOG4107QKW extracellular solute-binding protein family 1 D6I95_07835 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) D6I95_07840 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) D6I95_07845 ENOG4107YD3 Thioesterase D6I95_07850 ENOG4105E02 MotA TolQ exbB proton channel D6I95_07855 ENOG4105M8F Biopolymer transport protein exbD tolR D6I95_07865 ENOG4107R6Y Involved in the TonB-independent uptake of proteins (By similarity) D6I95_07870 ENOG4105KCK Peptidoglycan-associated lipoprotein D6I95_07895 ENOG4107QI1 Mate efflux family protein D6I95_07910 ENOG4105UIB (ABC) transporter D6I95_07915 ENOG4105C2J ABC transporter D6I95_07930 ENOG4108NIW Leucine export protein LeuE D6I95_07935 ENOG4105CYC Transferase D6I95_07940 ENOG4105CMU LysR family (Transcriptional regulator D6I95_07950 ENOG4107RDB Major Facilitator D6I95_07965 ENOG4108JU3 Alkyl hydroperoxide reductase D6I95_07980 ENOG4105T38 integral membrane protein D6I95_07990 ENOG4105C11 sulfate adenylyltransferase), subunit 2 D6I95_08005 ENOG4105C26 Dehydrogenase D6I95_08010 ENOG4105CJP fad dependent oxidoreductase D6I95_08020 ENOG4105ETT transcriptional Regulator, LysR family D6I95_08025 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) D6I95_08040 ENOG4105CC0 LysR family Transcriptional regulator D6I95_08045 ENOG4105C2I pirin domain protein D6I95_08050 ENOG4105BZU Histidine kinase D6I95_08060 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) D6I95_08065 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) D6I95_08070 ENOG41080IJ Diacylglycerol kinase D6I95_08075 ENOG4105SKN orotidine 5''-phosphate decarboxylase D6I95_08100 ENOG4107HP6 Transcriptional regulator D6I95_08110 ENOG4108ZAI phosphatidylglycerophosphatase a D6I95_08115 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) D6I95_08120 ENOG4107YIM Involved in the transcription termination process (By similarity) D6I95_08125 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) D6I95_08150 ENOG4106H78 methyltransferase D6I95_08155 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) D6I95_08160 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding D6I95_08190 ENOG4108T7K Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Increasing levels of c-di-GMP lead to decreased motility (By similarity) D6I95_08200 ENOG4108UAU isochorismatase D6I95_08215 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding D6I95_08220 ENOG4108XHQ (2Fe-2S)-binding domain protein D6I95_08225 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding D6I95_08235 ENOG4108IV0 ABC, transporter D6I95_08240 ENOG4105C0Z ABC transporter D6I95_08260 ENOG4105BZU Histidine kinase D6I95_08285 ENOG4107RZC phospholipase d D6I95_08295 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) D6I95_08300 ENOG4107P0T Selenium-dependent molybdenum hydroxylase system protein, YqeB family D6I95_08305 ENOG4105CG6 trap dicarboxylate transporter dctm subunit D6I95_08330 ENOG4105CH5 extracellular solute-binding protein, family 7 D6I95_08355 ENOG4108UAU isochorismatase D6I95_08380 ENOG4105E0A ABC, transporter D6I95_08385 ENOG4105EHG Permease protein D6I95_08395 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) D6I95_08400 ENOG4105CRW Short chain fatty acid transporter D6I95_08415 ENOG4108JDX DNA polymerase iii, epsilon subunit D6I95_08420 ENOG4105BZS acriflavin resistance protein D6I95_08425 ENOG410624X efflux transporter, rnd family, mfp subunit D6I95_08430 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) D6I95_08435 ENOG4105D1A Methyltransferase D6I95_08440 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) D6I95_08445 ENOG4105E9H Lytic Murein transglycosylase D6I95_08450 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH D6I95_08465 ENOG4105CK2 sodium dicarboxylate symporter D6I95_08475 ENOG4105C72 UPF0176 protein D6I95_08495 ENOG4108UIN ybak prolyl-trna synthetase associated region D6I95_08500 ENOG4108T2C cysteine dioxygenase type I D6I95_08510 ENOG4105CD5 CoA-binding domain protein D6I95_08520 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family D6I95_08530 ENOG4105E9F Enoyl-CoA hydratase D6I95_08580 ENOG4105K89 arsenate reductase D6I95_08585 ENOG4105CAU Arsenical resistance protein, ArsH D6I95_08590 ENOG4105XJC Two component transcriptional regulator (Winged helix family D6I95_08595 ENOG4105DHQ Histidine kinase D6I95_08615 ENOG4105C0R drug resistance transporter emrb qaca subfamily D6I95_08625 ENOG4105VDT -acetyltransferase D6I95_08630 ENOG4105ECQ AraC Family Transcriptional Regulator D6I95_08640 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) D6I95_08645 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) D6I95_08650 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) D6I95_08655 ENOG4108V1U phospholipid-binding protein D6I95_08660 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) D6I95_08665 ENOG4105DR5 peptidase D6I95_08670 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) D6I95_08690 ENOG4108YX9 iron--sulfur cluster insertion protein erpA D6I95_08700 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase D6I95_08705 ENOG4108UJD 30S ribosomal protein S9 D6I95_08710 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) D6I95_08715 ENOG4105CH5 extracellular solute-binding protein, family 7 D6I95_08720 ENOG4105CMS peptidase U62, modulator of DNA gyrase D6I95_08725 ENOG4105N42 UPF0307 protein D6I95_08735 ENOG4105CD5 CoA-binding domain protein D6I95_08740 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic D6I95_08750 ENOG4108ZXC Two component transcriptional regulator, luxr family D6I95_08755 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) D6I95_08760 ENOG4108VWS Yaeq family D6I95_08770 ENOG4105J0Q Transcriptional regulator D6I95_08785 ENOG4108VIA integral membrane protein D6I95_08790 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) D6I95_08795 ENOG4108XTF Outer Membrane Lipoprotein D6I95_08810 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) D6I95_08815 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase D6I95_08820 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein D6I95_08825 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) D6I95_08830 ENOG4108IFH alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen D6I95_08835 ENOG4105DFU Cell wall formation (By similarity) D6I95_08840 ENOG4105IPS esterase D6I95_08855 ENOG4105E2X shikimate dehydrogenase D6I95_08860 ENOG4108VKV Monofunctional biosynthetic peptidoglycan transglycosylase D6I95_08870 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) D6I95_08875 ENOG4108Z20 Acyl-transferase D6I95_08880 ENOG4107Y66 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) D6I95_08885 ENOG4108UJU UPF0301 protein D6I95_08890 ENOG4105VCQ rubredoxin D6I95_08900 ENOG4107U6I Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) D6I95_08905 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase D6I95_08925 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) D6I95_08935 ENOG4105VDW Csbd family D6I95_08940 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) D6I95_08945 ENOG4105K46 50S ribosomal protein l27 D6I95_08950 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control D6I95_08955 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) D6I95_08980 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) D6I95_08995 ENOG4105CDA abc transporter atp-binding protein D6I95_09000 ENOG4105DRP amino acid AbC transporter D6I95_09005 ENOG4105EZ7 amino acid ABC transporter D6I95_09015 ENOG4105CAK Cell division ATP-binding protein ftsE D6I95_09020 ENOG4105CRP Part of the ABC transporter FtsEX involved in D6I95_09025 ENOG4105CEN a g-specific adenine glycosylase D6I95_09030 ENOG4105CNI cell division protein FtsW D6I95_09035 ENOG4105CJN penicillin-binding protein D6I95_09045 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) D6I95_09050 ENOG4105DFF Rod shape-determining protein mreb D6I95_09055 ENOG41080G2 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) D6I95_09060 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) D6I95_09065 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) D6I95_09075 ENOG4105EJC lysr family transcriptional regulator D6I95_09080 ENOG4105MGM doxx family D6I95_09085 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b D6I95_09095 ENOG4105MPD Cytochrome D6I95_09105 ENOG41067TZ transcriptional regulator, MarR family D6I95_09110 ENOG4105CSU acyl-Coa dehydrogenase D6I95_09120 ENOG4105CD5 CoA-binding domain protein D6I95_09125 ENOG4108D7R p-hydroxycinnamoyl CoA hydratase lyase D6I95_09130 ENOG4105DSQ Nitric oxide reductase D6I95_09160 ENOG41060BG Tetr family transcriptional regulator D6I95_09175 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase D6I95_09200 ENOG4105ECP epimerase D6I95_09205 ENOG4105D6U Sodium Glutamate Symporter D6I95_09210 ENOG4105EAH synthase D6I95_09220 ENOG4105M6F mutator MutT protein D6I95_09225 ENOG4107S47 Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) (By similarity) D6I95_09230 ENOG4105ENJ RND efflux system, outer membrane lipoprotein D6I95_09240 ENOG4105BZS acriflavin resistance protein D6I95_09250 ENOG4105DHA Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity (By similarity) D6I95_09255 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) D6I95_09265 ENOG4105WH1 Two component transcriptional regulator luxr family D6I95_09275 ENOG4107R03 Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) D6I95_09280 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) D6I95_09290 ENOG4105C0R drug resistance transporter emrb qaca subfamily D6I95_09300 ENOG4105C3R Methionine synthase D6I95_09305 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) D6I95_09310 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) D6I95_09315 ENOG4105CNM Receptor D6I95_09325 ENOG4108SF5 RNA Polymerase D6I95_09330 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) D6I95_09335 ENOG4105DWF phosphomethylpyrimidine kinase D6I95_09340 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) D6I95_09345 ENOG4108KE4 O-methyltransferase D6I95_09350 ENOG4105DFG type I secretion outer membrane protein D6I95_09355 ENOG4107Z67 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) D6I95_09365 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) D6I95_09380 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) D6I95_09385 ENOG4105CK6 Two component transcriptional regulator (Winged helix family D6I95_09390 ENOG4105BZU Histidine kinase D6I95_09400 ENOG4105P4J Allophanate hydrolase, subunit 1 D6I95_09410 ENOG4105C7B Threonine dehydratase D6I95_09415 ENOG4105W39 Membrane D6I95_09435 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) D6I95_09440 ENOG4108JJ8 (ABC) transporter D6I95_09445 ENOG4108JJ9 ABC, transporter D6I95_09455 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii D6I95_09460 ENOG4105C4M (Ubiquinol oxidase) subunit I D6I95_09470 ENOG4105C2X Arabinose 5-phosphate isomerase D6I95_09475 ENOG4108Z4R 3-deoxy-d-manno-octulosonate 8-phosphate phosphatase D6I95_09490 ENOG4108IUZ ABC transporter D6I95_09495 ENOG41080QH sigma 54 modulation protein ribosomal protein S30EA D6I95_09500 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN D6I95_09505 ENOG4105D1C Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) D6I95_09510 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) D6I95_09520 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) D6I95_09525 ENOG41082RQ UPF0102 protein D6I95_09530 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) D6I95_09545 ENOG4105CAS nag kinase D6I95_09555 ENOG4105D06 uba thif-type nad fad binding protein D6I95_09560 ENOG4105CN1 protease D6I95_09565 ENOG41063SB peptidase D6I95_09570 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) D6I95_09575 ENOG4107YZP Rhodanese domain protein D6I95_09585 ENOG4105IX2 One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity) D6I95_09590 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase D6I95_09600 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) D6I95_09605 ENOG4105MJ2 Competence protein D6I95_09610 ENOG4106T9E Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) D6I95_09615 ENOG410908U Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) D6I95_09620 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family D6I95_09635 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B D6I95_09650 ENOG4108Z0R Transferase D6I95_09665 ENOG4105CNV Aldolase D6I95_09670 ENOG4108IY8 ABC, transporter D6I95_09720 ENOG4108MX3 Polysaccharide Biosynthesis Protein D6I95_09725 ENOG4105C1B dTDP-glucose 4-6-dehydratase D6I95_09730 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) D6I95_09735 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase D6I95_09750 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) D6I95_09755 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) D6I95_09760 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) D6I95_09765 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) D6I95_09770 ENOG4107S15 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) D6I95_09775 ENOG4107Z6K F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) D6I95_09780 ENOG4105KY6 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) D6I95_09785 ENOG4107RAZ it plays a direct role in the translocation of protons across the membrane (By similarity) D6I95_09795 ENOG4105E39 Enoyl-CoA hydratase D6I95_09810 ENOG4105CB3 Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity) D6I95_09815 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase D6I95_09825 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) D6I95_09835 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) D6I95_09845 ENOG4106TD9 Diguanylate cyclase D6I95_09860 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) D6I95_09870 ENOG4108KK1 membrane protein AbrB duplication D6I95_09890 ENOG4105GR3 Histidine kinase D6I95_09905 ENOG4105CSH Transporter D6I95_09910 ENOG4105ES4 Nitrilase D6I95_09925 ENOG4105E2Y ABC, transporter D6I95_09950 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) D6I95_09955 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) D6I95_09960 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein D6I95_09965 ENOG4108MG3 formate dehydrogenase D6I95_09970 ENOG4105F46 Necessary for formate dehydrogenase activity (By similarity) D6I95_09975 ENOG4105C1Y Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis (By similarity) D6I95_09980 ENOG4105EM7 Selenocysteine-specific translation elongation factor D6I95_09995 ENOG4108S8N class II Aldolase D6I95_10035 ENOG4105D4F Synthesizes selenophosphate from selenide and ATP (By similarity) D6I95_10040 ENOG4105CR7 Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA (By similarity) D6I95_10050 ENOG4105EQJ Nitrous-oxide reductase is part of a bacterial respiratory system which is activated under anaerobic conditions in the presence of nitrate or nitrous oxide (By similarity) D6I95_10060 ENOG4105CIG ABC transporter D6I95_10065 ENOG4108T0W nitrous oxide maturation protein NosY D6I95_10080 ENOG4107QP8 phosphohexose isomerase D6I95_10135 ENOG4108IJ1 Dehydrogenase D6I95_10150 ENOG4105ECX polysaccharide export D6I95_10160 ENOG41090SZ ABC-2 type transporter D6I95_10170 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) D6I95_10180 ENOG4105C2W permease D6I95_10185 ENOG4105T38 integral membrane protein D6I95_10190 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family D6I95_10195 ENOG4107Y9U Membrane D6I95_10205 ENOG4105CHU acetyl-coa acetyltransferase D6I95_10225 ENOG4105F04 LysR family Transcriptional regulator D6I95_10230 ENOG4105C7F AcnD-accessory protein PrpF D6I95_10240 ENOG4105DHJ ABC, transporter D6I95_10245 ENOG4105CY3 ABC transporter, permease D6I95_10250 ENOG4107PE3 Mammalian cell entry related domain protein D6I95_10265 ENOG4105DA5 (ABC) transporter D6I95_10270 ENOG4105E3A (ABC) transporter D6I95_10280 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) D6I95_10285 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) D6I95_10290 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) D6I95_10295 ENOG4105ECC imidazole-glycerol-phosphate dehydratase D6I95_10300 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) D6I95_10305 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase D6I95_10310 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) D6I95_10315 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase D6I95_10320 ENOG4105KPZ phosphoribosyl-atp pyrophosphatase D6I95_10325 ENOG4107YU2 histidine triad (hIT) protein D6I95_10330 ENOG4105WKS Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) D6I95_10345 ENOG4105C0H protease D6I95_10350 ENOG4107QNR UPF0135 protein D6I95_10355 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) D6I95_10360 ENOG4108R5F Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) D6I95_10365 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) D6I95_10370 ENOG4105EIX cytochrome c1 D6I95_10375 ENOG4107MKT Stringent starvation protein a D6I95_10380 ENOG4105KB2 stringent starvation protein b D6I95_10385 ENOG4105ECW sulfate abc transporter D6I95_10390 ENOG4108I5D sulfate abc transporter D6I95_10395 ENOG4108J2H Sulfate ABC transporter periplasmic sulfate-binding protein D6I95_10410 ENOG4105C5I Dehydrogenase D6I95_10420 ENOG4105CG6 trap dicarboxylate transporter dctm subunit D6I95_10430 ENOG4105CH5 extracellular solute-binding protein, family 7 D6I95_10435 ENOG4105EXW epimerase dehydratase D6I95_10440 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) D6I95_10450 ENOG4105C01 Dihydroxy-acid dehydratase D6I95_10455 ENOG4108WYP Transcriptional regulator D6I95_10460 ENOG4105F7P transcriptional regulator AsnC family D6I95_10465 ENOG4105HJ8 Catalyzes the oxidative cleavage of the L-tryptophan (L- Trp) pyrrole ring (By similarity) D6I95_10480 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) D6I95_10485 ENOG4105CV8 reductase D6I95_10495 ENOG4107QM5 aconitate hydratase D6I95_10500 ENOG4105BZU Histidine kinase D6I95_10505 ENOG4105DHI Methyltransferase D6I95_10535 ENOG4105F04 LysR family Transcriptional regulator D6I95_10540 ENOG4105CHR reductase D6I95_10550 ENOG4105VDW Csbd family D6I95_10555 ENOG4105K3G Periplasmic Protein D6I95_10565 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family D6I95_10595 ENOG4108SF5 RNA Polymerase D6I95_10605 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) D6I95_10610 ENOG4108XM1 transcriptional regulator AsnC family D6I95_10615 ENOG4105Q84 sucrose synthase D6I95_10620 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) D6I95_10635 ENOG4105CV4 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity) D6I95_10640 ENOG4105BZ9 Cytochrome C oxidase, subunit I D6I95_10650 ENOG4107QS1 Cytochrome C Oxidase, Subunit III D6I95_10675 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) D6I95_10680 ENOG4105EQD regulatoR D6I95_10700 ENOG4107RNH Outer membrane receptor FepA D6I95_10715 ENOG4107QPD alcohol dehydrogenase D6I95_10720 ENOG4105DZQ phospholipase D Transphosphatidylase D6I95_10725 ENOG4105X23 Endonuclease Exonuclease phosphatase D6I95_10730 ENOG4105C9M aspartyl-trna synthetase D6I95_10755 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family D6I95_10765 ENOG4105CI2 imidazolone-5-propionate hydrolase D6I95_10775 ENOG4105C84 Histidine ammonia-lyase D6I95_10780 ENOG4105CGP Urocanate hydratase D6I95_10805 ENOG4108Z6Z Transcriptional regulator D6I95_10835 ENOG4105CYM Glutathione S-transferase D6I95_10860 ENOG4105CGF Aromatic amino acid aminotransferase D6I95_10865 ENOG4105M2Z protein tyrosine serine phosphatase D6I95_10870 ENOG4105CY0 Metallo-Beta-Lactamase D6I95_10890 ENOG4105CIF Ornithine Cyclodeaminase D6I95_10935 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) D6I95_10950 ENOG4105DRR Transcriptional regulator, GntR family D6I95_10970 ENOG4105CZM Major Facilitator D6I95_10975 ENOG4108UUM single-stranded DNA-binding protein D6I95_10980 ENOG4107RDB Major Facilitator D6I95_10990 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein D6I95_10995 ENOG4105D49 3-dehydroquinate synthase D6I95_11000 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) D6I95_11005 ENOG4108JQC penicillin-binding protein 1A D6I95_11015 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) D6I95_11020 ENOG4105BZU Histidine kinase D6I95_11025 ENOG4105CRE cytochrome C D6I95_11030 ENOG4105EBH Required during biogenesis of c-type cytochromes (cytochrome c6 and cytochrome f) at the step of heme attachment (By similarity) D6I95_11040 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) D6I95_11045 ENOG4105D52 delta-aminolevulinic acid dehydratase D6I95_11050 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) D6I95_11070 ENOG4105EQP Catalyzes the pyrimidine ring opening between N-3 and C- 4 by an unusual flavin hydroperoxide-catalyzed mechanism to yield ureidoacrylate peracid. It cleaves pyrmidine rings directly by adding oxygen atoms, making a toxic ureidoacrylate peracid product which can be spontaneously reduced to ureidoacrylate (By similarity) D6I95_11075 ENOG4108ZT0 50S ribosomal protein l17 D6I95_11080 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) D6I95_11085 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) D6I95_11090 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) D6I95_11095 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits D6I95_11110 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) D6I95_11115 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) D6I95_11120 ENOG4105VPB 50S ribosomal protein L30 D6I95_11125 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) D6I95_11130 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) D6I95_11135 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) D6I95_11140 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) D6I95_11145 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) D6I95_11150 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits D6I95_11155 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) D6I95_11160 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) D6I95_11190 ENOG4108JJA ABC, transporter D6I95_11200 ENOG4105DFG type I secretion outer membrane protein D6I95_11220 ENOG4107QPN acyl-Coa dehydrogenase D6I95_11225 ENOG4105CHU acetyl-coa acetyltransferase D6I95_11230 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase D6I95_11235 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation D6I95_11250 ENOG4105CEY Amp-dependent synthetase and ligase D6I95_11255 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) D6I95_11260 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) D6I95_11265 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) D6I95_11280 ENOG4105D7T ABC transporter D6I95_11285 ENOG4105C1G acyl-Coa dehydrogenase D6I95_11300 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal D6I95_11305 ENOG41084PQ 50s ribosomal protein l29 D6I95_11310 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) D6I95_11315 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) D6I95_11320 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) D6I95_11325 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) D6I95_11330 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity D6I95_11335 ENOG41080KG One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) D6I95_11340 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) D6I95_11345 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) D6I95_11350 ENOG4108IJ7 Glycine betaine D6I95_11355 ENOG4108HQS Glycine betaine D6I95_11360 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) D6I95_11365 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) D6I95_11370 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) D6I95_11375 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) D6I95_11380 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) D6I95_11415 ENOG4107QR0 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) D6I95_11420 ENOG4107QIH DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) D6I95_11425 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) D6I95_11430 ENOG4108VZM 50s ribosomal protein L10 D6I95_11435 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) D6I95_11440 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) D6I95_11460 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) D6I95_11480 ENOG4105FA0 parb-like partition protein D6I95_11485 ENOG4107QJE Chromosome Partitioning Protein D6I95_11495 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) D6I95_11500 ENOG4105CHM Aminotransferase D6I95_11505 ENOG4107S1Q Phosphatase D6I95_11510 ENOG4105BZU Histidine kinase D6I95_11515 ENOG4105DJ4 phosphatidylserine decarboxylase D6I95_11525 ENOG4105C7B Threonine dehydratase D6I95_11535 ENOG4105JAB phenazine biosynthesis protein, phzf family D6I95_11570 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) D6I95_11615 ENOG4105CH6 catalase D6I95_11620 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins D6I95_11625 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) D6I95_11630 ENOG4105X5M RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) D6I95_11635 ENOG4105VG0 50S ribosomal protein l34 D6I95_11645 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) D6I95_11650 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) D6I95_11655 ENOG4105I08 Pseudouridine synthase D6I95_11685 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) D6I95_11695 ENOG4105CG6 trap dicarboxylate transporter dctm subunit D6I95_11715 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase D6I95_11730 ENOG4105CH5 extracellular solute-binding protein, family 7 D6I95_11745 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family D6I95_11765 ENOG4108Q5Y Membrane D6I95_11770 ENOG4105CKI cobalamin synthesis protein D6I95_11790 ENOG4108TGY Glutathione S-transferase D6I95_11830 ENOG4108SY4 MarR family Transcriptional regulator D6I95_11850 ENOG4105ERH Fumarylacetoacetate hydrolase D6I95_11855 ENOG4105ES4 Nitrilase D6I95_11860 ENOG4106IPI cyclase, family D6I95_11865 ENOG4105E3J oxidoreductase D6I95_11870 ENOG4105FUY alpha subunit D6I95_11895 ENOG4105CHR reductase D6I95_11905 ENOG4105CG6 trap dicarboxylate transporter dctm subunit D6I95_11915 ENOG41082W1 Cupin 2, conserved barrel domain protein D6I95_11920 ENOG41075H3 AraC family transcriptional regulator D6I95_11930 ENOG41061TZ Short-chain dehydrogenase reductase Sdr D6I95_11955 ENOG4105EW6 flavin reductase domain protein, FMN-binding D6I95_11960 ENOG4108JEH abc transporter atp-binding protein D6I95_11970 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) D6I95_11975 ENOG4108JQ7 (ABC) transporter D6I95_11980 ENOG4105C3U ABC transporter D6I95_11985 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component D6I95_11990 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component D6I95_11995 ENOG4105DEF Extracellular solute-binding protein, family 5 D6I95_12000 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) D6I95_12005 ENOG4105FQP Beta-lactamase D6I95_12010 ENOG4105C8Y Acetylornithine aminotransferase D6I95_12045 ENOG4107XWS modD protein D6I95_12050 ENOG4105E0C molybdate abc transporter D6I95_12060 ENOG4107QP3 malate synthase g D6I95_12070 ENOG4105FYV Amp nucleosidase D6I95_12080 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit D6I95_12085 ENOG4105CG6 trap dicarboxylate transporter dctm subunit D6I95_12100 ENOG4105C7K acetolactate synthase D6I95_12105 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit D6I95_12115 ENOG4105CG6 trap dicarboxylate transporter dctm subunit D6I95_12125 ENOG4108NS2 receptor D6I95_12145 ENOG4105C9U ATP-dependent DNA helicase RecQ D6I95_12155 ENOG4108RPN Protein smg homolog D6I95_12175 ENOG4107QX3 carboxylase D6I95_12180 ENOG4105CHU acetyl-coa acetyltransferase D6I95_12185 ENOG4105VS7 Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation (By similarity) D6I95_12190 ENOG4105C1G acyl-Coa dehydrogenase D6I95_12210 ENOG4108Z33 Thiol disulfide Interchange Protein D6I95_12220 ENOG4105C75 arginyL-tRNA synthetase D6I95_12245 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) D6I95_12255 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) D6I95_12265 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) D6I95_12270 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) D6I95_12275 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase D6I95_12280 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F D6I95_12285 ENOG4105CG6 trap dicarboxylate transporter dctm subunit D6I95_12295 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit D6I95_12300 ENOG4108UAU isochorismatase D6I95_12305 ENOG4107R11 Transcriptional regulator D6I95_12315 ENOG4108UQY Iron-storage protein D6I95_12325 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) D6I95_12330 ENOG410829K Lysine exporter protein (Lyse ygga) D6I95_12335 ENOG4105C1J atp-dependent rna helicase D6I95_12345 ENOG4105HA9 of methanol dehydrogenase type D6I95_12360 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) D6I95_12375 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) D6I95_12390 ENOG4105CVI Transcriptional regulator D6I95_12410 ENOG4105CG6 trap dicarboxylate transporter dctm subunit D6I95_12425 ENOG4105DHJ ABC, transporter D6I95_12440 ENOG4107YBY Hydrolase D6I95_12445 ENOG4108NDG TRAP dicarboxylate D6I95_12455 ENOG4105CG6 trap dicarboxylate transporter dctm subunit D6I95_12490 ENOG4107YCY Transcriptional regulator D6I95_12500 ENOG4105RQF LysR family Transcriptional regulator D6I95_12505 ENOG4105MWK D-amino acid dehydrogenase, small subunit D6I95_12515 ENOG4105CGY Dna recombination protein D6I95_12520 ENOG4105BZU Histidine kinase D6I95_12525 ENOG4105VSY K01512 acylphosphatase EC 3.6.1.7 D6I95_12545 ENOG4105D3G Pseudouridine synthase D6I95_12550 ENOG4105HDK L-asparaginase D6I95_12570 ENOG4108JEH abc transporter atp-binding protein D6I95_12575 ENOG4105D82 Glutamate dehydrogenase D6I95_12580 ENOG4105DFA alanine racemase domain protein D6I95_12600 ENOG4105C0Z ABC transporter D6I95_12605 ENOG4105C32 Amino acid ABC transporter (Permease) D6I95_12620 ENOG4108IV0 ABC, transporter D6I95_12630 ENOG4107QXX ABC transporter D6I95_12640 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase D6I95_12645 ENOG4105C79 DNA protecting protein DprA D6I95_12650 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) D6I95_12655 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) D6I95_12675 ENOG4105CG6 trap dicarboxylate transporter dctm subunit D6I95_12690 ENOG4105CFM UPF0317 protein D6I95_12695 ENOG4105SKE transcriptional Regulator LysR family D6I95_12700 ENOG4105D16 lipopolysaccharide heptosyltransferase i D6I95_12705 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase D6I95_12710 ENOG4105VEQ Cold shock protein D6I95_12715 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase D6I95_12720 ENOG4108194 Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) D6I95_12725 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase D6I95_12735 ENOG4105DZ1 carboxypeptidase D6I95_12740 ENOG4105F0I Aminotransferase D6I95_12745 ENOG4108Z43 UPF0250 protein D6I95_12750 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) D6I95_12755 ENOG4105E39 Enoyl-CoA hydratase D6I95_12760 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) D6I95_12770 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) D6I95_12815 ENOG4105CFP Peptidase U32 D6I95_12825 ENOG4105XPQ lipid carrier protein D6I95_12850 ENOG4105DK0 Indole-3-glycerol phosphate synthase D6I95_12855 ENOG4108I0Q anthranilate phosphoribosyltransferase D6I95_12860 ENOG4105DDQ anthranilate synthase D6I95_12870 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) D6I95_12880 ENOG4105DJV ribulose-phosphate 3-epimerase D6I95_12885 ENOG4105NWN ApaG protein D6I95_12890 ENOG4105CA3 membrane-bound lytic murein transglycosylase D6I95_12895 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family D6I95_12900 ENOG4105T95 Thiol disulfide interChange protein D6I95_12910 ENOG41080BE Methyl-accepting chemotaxis sensory transducer D6I95_12920 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase D6I95_12925 ENOG4105WQI isochorismatase D6I95_12930 ENOG4105E4F Isochorismate synthase D6I95_12945 ENOG4105CEY Amp-dependent synthetase and ligase D6I95_12950 ENOG4105WQI isochorismatase D6I95_12955 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase D6I95_12965 ENOG4108IV0 ABC, transporter D6I95_12970 ENOG4105C0Z ABC transporter D6I95_12985 ENOG4105CAD extracellular ligand-binding receptor D6I95_13000 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component D6I95_13035 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) D6I95_13040 ENOG4105EHG Permease protein D6I95_13045 ENOG4105NIV Esterase D6I95_13050 ENOG4105C1J atp-dependent rna helicase D6I95_13055 ENOG4105C2C drug resistance transporter, Bcr CflA D6I95_13075 ENOG4105EE5 Membrane protein terC D6I95_13120 ENOG4105K5X acetyltransferase D6I95_13135 ENOG4107XC4 flavin reductase domain protein, FMN-binding D6I95_13155 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component D6I95_13170 ENOG4105RQF LysR family Transcriptional regulator D6I95_13175 ENOG4105EAB amino acid AbC transporter D6I95_13180 ENOG4105CDA abc transporter atp-binding protein D6I95_13185 ENOG4105DRP amino acid AbC transporter D6I95_13190 ENOG4105EAD ABC transporter D6I95_13195 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) D6I95_13200 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) D6I95_13250 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) D6I95_13255 ENOG4105C25 Primosomal protein n' D6I95_13260 ENOG4105C4R Atp-dependent dna helicase D6I95_13295 ENOG4108D7R p-hydroxycinnamoyl CoA hydratase lyase D6I95_13305 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F D6I95_13310 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase D6I95_13315 ENOG4105MPD Cytochrome D6I95_13330 ENOG4105UGU tonB-dependent Receptor D6I95_13335 ENOG4105D9M gamma-glutamylcysteine synthetase D6I95_13345 ENOG4105VJY transcriptional regulator D6I95_13350 ENOG4105DWV Homoserine O-trans-acetylase D6I95_13360 ENOG4105EYM Major Facilitator superfamily D6I95_13365 ENOG4105EN6 Membrane D6I95_13370 ENOG41067MG lrgb family D6I95_13380 ENOG4105KME endoribonuclease L-psp D6I95_13385 ENOG4105KME endoribonuclease L-psp D6I95_13395 ENOG4108VYJ response regulator receiver protein D6I95_13410 ENOG4105CCF Lysine exporter protein (Lyse ygga) D6I95_13425 ENOG4105EXG Transcriptional regulator D6I95_13435 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) D6I95_13450 ENOG4108WBT adenosyltransferase D6I95_13465 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) D6I95_13470 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) D6I95_13475 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters D6I95_13480 ENOG4105CKI cobalamin synthesis protein D6I95_13485 ENOG4105MYN Zinc uptake regulation protein D6I95_13490 ENOG4105DIK (ABC) transporter D6I95_13495 ENOG4105CC5 ABC transporter D6I95_13500 ENOG4105DSE periplasmic solute binding protein D6I95_13505 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) D6I95_13515 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) D6I95_13520 ENOG4105D1S lipid A biosynthesis D6I95_13530 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP D6I95_13535 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) D6I95_13540 ENOG41082T9 Membrane D6I95_13545 ENOG4105SYT Methylenetetrahydrofolate reductase D6I95_13555 ENOG4107SC1 transglycosylase D6I95_13575 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) D6I95_13580 ENOG4108VCT Sulfite exporter TauE/SafE D6I95_13585 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) D6I95_13590 ENOG4105C01 Dihydroxy-acid dehydratase D6I95_13605 ENOG4107RA1 nh(3)-dependent nad( ) synthetase D6I95_13635 ENOG4105IPI Membrane D6I95_13665 ENOG4105MEW serine threonine protein phosphatase D6I95_13720 ENOG4105E0K tonB-dependent siderophore receptor D6I95_13725 ENOG4105HDK L-asparaginase D6I95_13730 ENOG4108IJ0 Aspartate ammonia-lyase D6I95_13755 ENOG4105GVJ transcriptional regulator D6I95_13775 ENOG4108IPW abc transporter atp-binding protein D6I95_13800 ENOG4105CXG d-lactate dehydrogenase D6I95_13810 ENOG41073TP transcriptional regulator D6I95_13815 ENOG4105DAA L-lactate D6I95_13830 ENOG4105CZE histidine utilization repressor D6I95_13835 ENOG4105F7P transcriptional regulator AsnC family D6I95_13845 ENOG4105C85 amino acid D6I95_13850 ENOG4105EFZ amidohydrolase D6I95_13855 ENOG4105E98 transcriptional regulator DeoR family D6I95_13860 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) D6I95_13865 ENOG4105BZ7 extracellular solute-binding protein family 1 D6I95_13875 ENOG4105DRS transport system, permease D6I95_13890 ENOG4108ZCF integral membrane protein D6I95_13895 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) D6I95_13900 ENOG4105DQ6 Transposase D6I95_13910 ENOG4108UPT UPF0178 protein D6I95_13920 ENOG4105EST Metal Dependent Phosphohydrolase D6I95_13925 ENOG4105VEJ Heat shock protein D6I95_13935 ENOG41064MX Tetr family transcriptional regulator D6I95_13945 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) D6I95_13955 ENOG4106NZI LysR family Transcriptional regulator D6I95_13980 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) D6I95_13985 ENOG4108ESX Receptor D6I95_13990 ENOG4107E2E PKHD-type hydroxylase D6I95_14015 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY D6I95_14020 ENOG4109066 lysm domain bon superfamily protein D6I95_14025 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) D6I95_14035 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) D6I95_14075 ENOG4105BZU Histidine kinase D6I95_14085 ENOG4105CSH Transporter D6I95_14090 ENOG4108S8N class II Aldolase D6I95_14100 ENOG4108NS2 receptor D6I95_14105 ENOG4107Y2X deaminase D6I95_14110 ENOG4105S0E allantoin catabolism protein D6I95_14115 ENOG4108M0I Transcriptional regulator D6I95_14125 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) D6I95_14135 ENOG4105D1F ATP-binding protein D6I95_14150 ENOG4105DHP deoxycytidine triphosphate deaminase D6I95_14155 ENOG4105CXN decarboxylase D6I95_14160 ENOG4105CBX hi0933 family D6I95_14165 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) D6I95_14175 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) D6I95_14180 ENOG4108UKZ OsmC family D6I95_14210 ENOG4108S0N Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol (By similarity) D6I95_14215 ENOG4105CA9 Pyruvate kinase D6I95_14220 ENOG4108ZJF Glcg protein D6I95_14230 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase D6I95_14235 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) D6I95_14240 ENOG41060W2 glyoxylate carboligase D6I95_14245 ENOG4105EJC lysr family transcriptional regulator D6I95_14255 ENOG4105C2W permease D6I95_14260 ENOG41084KP 4-oxalocrotonate tautomerase D6I95_14270 ENOG4105FFA Catalyzes the oxidation of uric acid to 5- hydroxyisourate, which is further processed to form (S)-allantoin (By similarity) D6I95_14280 ENOG4107UKG Glycosyl transferase, family 4 D6I95_14285 ENOG4107QQG Dehydrogenase D6I95_14300 ENOG4105CG5 Glycosyl transferase (Group 1 D6I95_14305 ENOG4107XU6 Glycosyl transferase (Group 1 D6I95_14310 ENOG4105CGN Glycosyl transferase (Group 1 D6I95_14320 ENOG4105CQB FAD linked oxidase domain protein D6I95_14335 ENOG4105CE1 Ferrous iron transport protein b D6I95_14345 ENOG4105ERH Fumarylacetoacetate hydrolase D6I95_14350 ENOG4105F1J Homogentisate 1,2-dioxygenase D6I95_14360 ENOG4105E2Q 3-(3-hydroxy-phenyl)propionate hydroxylase D6I95_14370 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) D6I95_14380 ENOG41081V9 Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein (By similarity) D6I95_14395 ENOG4105C5T Phosphoribosyl pyrophosphate synthase D6I95_14400 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) D6I95_14405 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) D6I95_14415 ENOG4105C3G gtp-binding protein D6I95_14420 ENOG4108F3G Type I restriction-modification system, R subunit D6I95_14430 ENOG4105DFS Conserved Protein D6I95_14435 ENOG4107QTH restriction modification system DNA specificity domain D6I95_14440 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) D6I95_14480 ENOG4106JUT Streptomycin 3''-adenylyltransferase D6I95_14485 ENOG4105C5H ABC transporter D6I95_14495 ENOG4107B2H carbonic anhydrase D6I95_14500 ENOG4105DND Transcriptional regulator D6I95_14515 ENOG4105CA5 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity) D6I95_14520 ENOG41060IM Heme exporter protein D6I95_14535 ENOG4105DA4 cytochrome c-type biogenesis protein D6I95_14540 ENOG4107QX9 Thiol disulfide interChange protein D6I95_14545 ENOG4105KWW Biogenesis protein D6I95_14550 ENOG4108M1T Cytochrome c-type biogenesis protein D6I95_14555 ENOG4107QIV Cytochrome c biogenesis protein D6I95_14560 ENOG4107EXU Short-chain dehydrogenase reductase Sdr D6I95_14565 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) D6I95_14585 ENOG4105C32 Amino acid ABC transporter (Permease) D6I95_14590 ENOG4105CF8 branched-chain amino acid ABC transporter, permease D6I95_14595 ENOG4105C0Z ABC transporter D6I95_14600 ENOG4108IV0 ABC, transporter D6I95_14605 ENOG4105CA0 peroxidase D6I95_14610 ENOG4108JQ1 Dehydrogenase D6I95_14615 ENOG4105KPV Transcriptional regulator D6I95_14620 ENOG4105VIG Sec-independent protein translocase protein TatC D6I95_14660 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) D6I95_14665 ENOG4108IEG Formate dehydrogenase Alpha subunit D6I95_14670 ENOG4107QIZ NADH dehydrogenase D6I95_14680 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family D6I95_14685 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) D6I95_14690 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) D6I95_14705 ENOG4105CVM Molybdenum cofactor synthesis domain protein D6I95_14710 ENOG4108RIR Molybdenum cofactor biosynthesis protein D6I95_14715 ENOG4108ZAF Molybdopterin D6I95_14725 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) D6I95_14730 ENOG4108ZXC Two component transcriptional regulator, luxr family D6I95_14735 ENOG4105BZU Histidine kinase D6I95_14740 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit D6I95_14745 ENOG4108RA0 tripartite ATP-independent periplasmic transporter, DctQ component D6I95_14750 ENOG4105CG6 trap dicarboxylate transporter dctm subunit D6I95_14770 ENOG4108TZV Membrane D6I95_14775 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) D6I95_14795 ENOG410624X efflux transporter, rnd family, mfp subunit D6I95_14820 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family D6I95_14825 ENOG4105EXG Transcriptional regulator D6I95_14830 ENOG4105C26 Dehydrogenase D6I95_14835 ENOG4108WUH Transcriptional regulator, TetR family D6I95_14845 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F D6I95_14890 ENOG4105BZU Histidine kinase D6I95_14895 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) D6I95_14900 ENOG4108JU5 Magnesium and cobalt efflux protein D6I95_14905 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) D6I95_14910 ENOG4105C9A Phoh family D6I95_14915 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) D6I95_14925 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) D6I95_14930 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) D6I95_14935 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) D6I95_14940 ENOG4105VIE preprotein translocase, subunit YajC D6I95_14945 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) D6I95_14950 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) D6I95_14955 ENOG4106HRJ d-alanyl-d-alanine carboxypeptidase D6I95_14960 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) D6I95_14970 ENOG4105TNS Conserved Protein D6I95_14985 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) D6I95_14995 ENOG4105CHM Aminotransferase D6I95_15005 ENOG4105C6K Malic enzyme D6I95_15015 ENOG41067XF inhibitor D6I95_15020 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) D6I95_15025 ENOG4105CV1 Transketolase (EC 2.2.1.1) D6I95_15030 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase D6I95_15035 ENOG4105BZA Phosphoglycerate kinase D6I95_15060 ENOG4108RIR Molybdenum cofactor biosynthesis protein D6I95_15070 ENOG4105C8V SAICAR synthetase D6I95_15075 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) D6I95_15080 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit D6I95_15085 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) D6I95_15090 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) D6I95_15100 ENOG4105DXM phenylacetic acid degradation protein D6I95_15105 ENOG4105C1G acyl-Coa dehydrogenase D6I95_15110 ENOG4108MGI Transcriptional regulator D6I95_15115 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) D6I95_15125 ENOG4105D5U fad dependent oxidoreductase D6I95_15135 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) D6I95_15145 ENOG4105CUZ uba thif-type nad fad binding protein D6I95_15155 ENOG4105CRQ synthase (Component I) D6I95_15160 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) D6I95_15175 ENOG4105C5H ABC transporter D6I95_15195 ENOG4105VJP Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity) D6I95_15200 ENOG4107QMS site-determining protein D6I95_15210 ENOG4105CX6 glutaminyL-tRNA synthetase D6I95_15220 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii D6I95_15235 ENOG4105C9U ATP-dependent DNA helicase RecQ D6I95_15240 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) D6I95_15245 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) D6I95_15250 ENOG4105XPH Ferredoxin D6I95_15255 ENOG4105C5H ABC transporter D6I95_15265 ENOG4108V6E Cell division protein mraZ D6I95_15270 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) D6I95_15275 ENOG4105N8N Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) D6I95_15280 ENOG4105CJN penicillin-binding protein D6I95_15285 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) D6I95_15290 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) D6I95_15295 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) D6I95_15305 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) D6I95_15310 ENOG4105DFU Cell wall formation (By similarity) D6I95_15315 ENOG4105CPF Cell wall formation (By similarity) D6I95_15320 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) D6I95_15325 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) D6I95_15330 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) D6I95_15335 ENOG4105C7C involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) D6I95_15345 ENOG4105E4C Lytic transglycosylase catalytic D6I95_15350 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving D6I95_15365 ENOG4105CJW magnesium transporter D6I95_15370 ENOG4105NAU thioesterase Superfamily protein D6I95_15375 ENOG4105CH2 amidohydrolase D6I95_15380 ENOG4105CEY Amp-dependent synthetase and ligase D6I95_15385 ENOG4105ECY inositol monophosphatase D6I95_15390 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) D6I95_15405 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) D6I95_15410 ENOG4108UMI ABC transporter, permease D6I95_15415 ENOG4105D01 (LipO)protein D6I95_15420 ENOG4107R0W ABC transporter D6I95_15425 ENOG4105E5Q amino acid AbC transporter D6I95_15430 ENOG4105CDA abc transporter atp-binding protein D6I95_15440 ENOG4108S0S Nucleotidyl transferase D6I95_15445 ENOG4105EHM Aminoglycoside phosphotransferase D6I95_15455 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) D6I95_15460 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) D6I95_15480 ENOG4105E9Q Acyl-transferase D6I95_15485 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase D6I95_15490 ENOG4105C38 Glycyl-tRNA synthetase beta subunit D6I95_15495 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit D6I95_15500 ENOG4105E39 Enoyl-CoA hydratase D6I95_15505 ENOG4107GFK fumarate D6I95_15510 ENOG4108IG5 Transcriptional regulator D6I95_15535 ENOG4105DJ0 Poly(A) Polymerase D6I95_15545 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) D6I95_15550 ENOG4105CXB phosphoribosylaminoimidazole synthetase D6I95_15555 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease D6I95_15560 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) D6I95_15565 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) D6I95_15570 ENOG4105DQR SNARE associated Golgi D6I95_15575 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase D6I95_15580 ENOG4105K8N protein family UPF0079, ATPase D6I95_15595 ENOG4105C6K Malic enzyme D6I95_15600 ENOG4105DDW LysR family Transcriptional regulator D6I95_15605 ENOG4105C26 Dehydrogenase D6I95_15610 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) D6I95_15620 ENOG4105CG6 trap dicarboxylate transporter dctm subunit D6I95_15650 ENOG4105KVH Transcriptional regulator D6I95_15655 ENOG4108RYK Nad-dependent epimerase dehydratase D6I95_15665 ENOG4108Z66 YbaK ebsC protein D6I95_15670 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) D6I95_15675 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein D6I95_15680 ENOG4105E0C molybdate abc transporter D6I95_15685 ENOG4108IJ6 ABC transporter D6I95_15690 ENOG4105F4R Transcriptional regulator mode D6I95_15700 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation D6I95_15710 ENOG4107QMP dna polymerase iii subunits gamma and tau D6I95_15720 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) D6I95_15725 ENOG4107BVJ 4,5-dihydroxyphthalate decarboxylase D6I95_15735 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component D6I95_15755 ENOG4108NS2 receptor D6I95_15760 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) D6I95_15765 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain D6I95_15770 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain D6I95_15795 ENOG4105C2W permease D6I95_15800 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) D6I95_15805 ENOG4105HBR Rna-binding protein D6I95_15810 ENOG4105F7M Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity) D6I95_15815 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) D6I95_15820 ENOG4105EEI dihydropteroate synthase D6I95_15825 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) D6I95_15835 ENOG4105C9X ppx gppa phosphatase D6I95_15840 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) D6I95_15845 ENOG4107QMV Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) D6I95_15850 ENOG4105C8U phosphate abc transporter D6I95_15855 ENOG4105E2Z phosphate ABC transporter (Permease D6I95_15860 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) D6I95_15870 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) D6I95_15885 ENOG4105XJC Two component transcriptional regulator (Winged helix family D6I95_15890 ENOG4105E0F Histidine kinase D6I95_15905 ENOG4105GZI Transcriptional regulator D6I95_15925 ENOG4105E0M Sulfatase D6I95_15955 ENOG4107QN1 sodium solute D6I95_15960 ENOG4105V9J phenylacetic acid degradation operon negative regulatory protein D6I95_15965 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) D6I95_15980 ENOG4107RTD sua5 ycio yrdc ywlc family protein D6I95_15985 ENOG4108Z4T Peptidase M50 D6I95_15990 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) D6I95_15995 ENOG4105GJM (LipO)protein D6I95_16010 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) D6I95_16020 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) D6I95_16025 ENOG4106A3M Cytochrome p-450 D6I95_16030 ENOG4105DKK Benzoate D6I95_16040 ENOG4105EZE Cupin 4 family protein D6I95_16045 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) D6I95_16050 ENOG4108NS2 receptor D6I95_16085 ENOG4108Y1S CRISPR-associated protein, Csy4 family D6I95_16095 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) D6I95_16100 ENOG4105ENJ RND efflux system, outer membrane lipoprotein D6I95_16105 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) D6I95_16110 ENOG4105BZ1 (ABC) transporter D6I95_16115 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) D6I95_16130 ENOG4105DEN Luciferase family D6I95_16140 ENOG4105D64 Mechanosensitive ion channel D6I95_16160 ENOG4105ECY inositol monophosphatase D6I95_16165 ENOG4105EE5 Membrane protein terC D6I95_16170 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) D6I95_16175 ENOG4105F10 Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity) D6I95_16190 ENOG4105C8N cysteinyl-tRNA synthetase D6I95_16200 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) D6I95_16205 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) D6I95_16210 ENOG4105CFH Aspartokinase D6I95_16225 ENOG4105EPW hflc protein D6I95_16235 ENOG4107S4Z Activates expression of the rhaBAD and rhaT operons (By similarity) D6I95_16260 ENOG4107RUE extracellular solute-binding protein family 1 D6I95_16265 ENOG4105ECW sulfate abc transporter D6I95_16270 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) D6I95_16275 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) D6I95_16280 ENOG4105W8H transhydrogenase (subunit alpha D6I95_16285 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) D6I95_16305 ENOG4105DMF Dehydrogenase D6I95_16310 ENOG4105CHF Glutathione S-transferase D6I95_16315 ENOG4105CS1 NAD(P)H quinone oxidoreductase D6I95_16330 ENOG4108VX5 3-methyladenine DNA glycosylase D6I95_16335 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) D6I95_16345 ENOG4105D7N magnesium and cobalt transport protein CorA D6I95_16350 ENOG4105CSU acyl-Coa dehydrogenase D6I95_16360 ENOG4105DEF Extracellular solute-binding protein, family 5 D6I95_16370 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component D6I95_16375 ENOG4108JQ6 ABC transporter D6I95_16385 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family D6I95_16390 ENOG4105C26 Dehydrogenase D6I95_16395 ENOG4105C0A alcohol dehydrogenase D6I95_16415 ENOG4105CG6 trap dicarboxylate transporter dctm subunit D6I95_16420 ENOG4105GQU Trap dicarboxylate transporter, dctp subunit D6I95_16430 ENOG4105CHU acetyl-coa acetyltransferase D6I95_16445 ENOG4105CHR reductase D6I95_16450 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) D6I95_16465 ENOG4107QIJ Aconitate hydratase 2 D6I95_16480 ENOG4105BZN citrate synthase D6I95_16485 ENOG4105CR4 methylisocitrate lyase D6I95_16490 ENOG4108JU7 Transcriptional regulator D6I95_16505 ENOG4105D9Z Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) D6I95_16510 ENOG4105FDP GntR family transcriptional regulator D6I95_16515 ENOG4108UTY succinate dehydrogenase, cytochrome b556 subunit D6I95_16530 ENOG4105E33 succinate dehydrogenase D6I95_16535 ENOG41060IS Flavinator of succinate dehydrogenase D6I95_16540 ENOG4105BZN citrate synthase D6I95_16545 ENOG41073TP transcriptional regulator D6I95_16550 ENOG4105DAA L-lactate D6I95_16555 ENOG4105C6K Malic enzyme D6I95_16560 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 D6I95_16565 ENOG4105C7S Dehydrogenase D6I95_16570 ENOG4107QN2 dihydrolipoyl dehydrogenase D6I95_16575 ENOG4105D6Z AFG1 family ATPase D6I95_16580 ENOG4105C31 Tryptophanyl-tRNA synthetase D6I95_16590 ENOG4105BZM domain protein D6I95_16595 ENOG4105DVT helicase D6I95_16600 ENOG4105CHH sulfate transporter D6I95_16610 ENOG4105C34 Pseudouridine synthase D6I95_16615 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase D6I95_16620 ENOG4105D1N poly(r)-hydroxyalkanoic acid synthase, class D6I95_16625 ENOG4105CHR reductase D6I95_16630 ENOG4108NVM synthesis repressor PhaR D6I95_16655 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) D6I95_16660 ENOG4105FE9 pseudouridine synthase D6I95_16665 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) D6I95_16670 ENOG4105CHV Transcription elongation factor NusA D6I95_16675 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) D6I95_16680 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) D6I95_16685 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) D6I95_16705 ENOG4106YG3 ABC transporter D6I95_16710 ENOG4105DSP amino acid AbC transporter D6I95_16715 ENOG4105E89 ABC transporter D6I95_16720 ENOG4108URH decarboxylase D6I95_16725 ENOG4105C2M dna polymerase I D6I95_16730 ENOG4105EAM Na Pi-cotransporter D6I95_16735 ENOG4105D0M Protease HtpX homolog D6I95_16745 ENOG4105KHC sulfurtransferase D6I95_16750 ENOG41082UU Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) D6I95_16755 ENOG4105CTB Polyprenyl synthetase D6I95_16760 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) D6I95_16765 ENOG4105DZA Converts GTP to 7,8-dihydroneopterin triphosphate (By similarity) D6I95_16770 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) D6I95_16780 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) D6I95_16785 ENOG4105K9Q Binds to the 23S rRNA (By similarity) D6I95_16790 ENOG4105CDU Replicative dna helicase D6I95_16795 ENOG4105DHU Bile acid D6I95_16800 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) D6I95_16805 ENOG4108IAB Phoh family D6I95_16810 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen D6I95_16815 ENOG4108UIV Protein of unknown function (DUF498/DUF598) D6I95_16820 ENOG4105CHM Aminotransferase D6I95_16825 ENOG4105D6E homoserine dehydrogenase D6I95_16840 ENOG4108MK9 spermidine N(1)-acetyltransferase D6I95_16845 ENOG4105CVN desaturase D6I95_16855 ENOG4105FBD synthase D6I95_16860 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) D6I95_16865 ENOG4105CHR reductase D6I95_16870 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) D6I95_16890 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) D6I95_16895 ENOG4105F38 ABC transporter, permease D6I95_16900 ENOG4105D38 putrescine abc transporter D6I95_16910 ENOG4105E66 phosphoriboisomerase A D6I95_16915 ENOG4108UTW Plays a role in the regulation of phosphate uptake D6I95_16925 ENOG4105KMG Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes (By similarity) D6I95_16930 ENOG4108EKC n-acetylglutamate synthase D6I95_16935 ENOG4105CQ7 ATP-dependent helicase D6I95_16940 ENOG4105C0B DNA polymerase III (alpha subunit) D6I95_16945 ENOG4105CPK Glycosyl transferase (Group 1 D6I95_16950 ENOG4107BJW polysaccharide deacetylase D6I95_16955 ENOG4106WTF Glycosyl transferase, family 2 D6I95_16965 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) D6I95_16975 ENOG4105KRS Proteinase inhibitor D6I95_16990 ENOG4105BZ1 (ABC) transporter D6I95_17005 ENOG4105C03 ribonuclease D6I95_17045 ENOG4108KWP DNA-binding transcriptional regulator GlcC D6I95_17050 ENOG4105CQB FAD linked oxidase domain protein D6I95_17055 ENOG4105EU8 FAD linked oxidase domain protein D6I95_17060 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) D6I95_17080 ENOG4105GAK amidohydrolase 2 D6I95_17090 ENOG4105KHM amidohydrolase 2 D6I95_17095 ENOG4105D2S major facilitator superfamily D6I95_17105 ENOG4105EF7 Transcriptional regulator D6I95_17110 ENOG4105C0R drug resistance transporter emrb qaca subfamily D6I95_17135 ENOG41072AC 4-hydroxybenzoate 3-monooxygenase D6I95_17165 ENOG4108REF Sporulation integral membrane protein ytvi D6I95_17180 ENOG4108Z9W Outer membrane porin D6I95_17190 ENOG4106UX7 integral membrane protein D6I95_17200 ENOG4105DUM transcriptional regulator, lysR family D6I95_17210 ENOG4108YY7 Invasion gene expression up-regulator SirB D6I95_17220 ENOG41080HT Transcriptional regulator, arsr family D6I95_17235 ENOG4105W1Y Transcriptional regulator D6I95_17245 ENOG4105CHH sulfate transporter D6I95_17250 ENOG4105YB8 TM2 domain containing protein D6I95_17255 ENOG4107QVN Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) D6I95_17260 ENOG4105C6V Glycerol-3-phosphate dehydrogenase D6I95_17265 ENOG4105K4H Nlp p60 protein D6I95_17270 ENOG4105GEH Functions in complex with FlhC as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region. Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes. Also regulates genes whose products function in a variety of physiological pathways (By similarity) D6I95_17275 ENOG4106CIA Functions in complex with FlhD as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region D6I95_17280 ENOG4107RD7 Flagellar Motor Protein, MotA D6I95_17285 ENOG4105ER2 Ompa motb domain protein D6I95_17290 ENOG4105CBS Chea signal transduction histidine kinase D6I95_17295 ENOG4108V3W Chemotaxis protein, CheW D6I95_17300 ENOG4105C8Q Methyl-accepting chemotaxis D6I95_17305 ENOG4105BZU Histidine kinase D6I95_17315 ENOG4108VYJ response regulator receiver protein D6I95_17320 ENOG4108KCC Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P) (By similarity) D6I95_17325 ENOG4105D00 flagellar biosynthetic protein flhB D6I95_17330 ENOG4105D7B Flagellar biosynthesis protein flha D6I95_17335 ENOG4105FZW flagellar biosynthesis regulator FlhF D6I95_17345 ENOG4105M9M anti-sigma28 factor FlgM D6I95_17355 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) D6I95_17360 ENOG4108ZC9 flagellar basal-body rod protein flgc D6I95_17365 ENOG4105W00 Flagellar hook capping protein D6I95_17370 ENOG4105BZE flagellar hook protein, FlgE D6I95_17375 ENOG4108KPB Flagellar basal-body rod protein FlgF D6I95_17380 ENOG4105CGA flagellar basal-body rod protein FlgG D6I95_17390 ENOG4105D92 Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) D6I95_17395 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj D6I95_17400 ENOG4105E1Q flagellar hook-associated protein D6I95_17405 ENOG4105DTJ flagellar hook-associated protein D6I95_17410 ENOG4105C8Q Methyl-accepting chemotaxis D6I95_17420 ENOG4105C8Q Methyl-accepting chemotaxis D6I95_17435 ENOG4105D19 Role in flagellar biosynthesis (By similarity) D6I95_17440 ENOG4105VS8 Flagellar biosynthetic protein fliq D6I95_17445 ENOG4105CN7 Flagellar biosynthetic protein FliP D6I95_17455 ENOG4105DD5 Flagellar motor switch protein D6I95_17460 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) D6I95_17465 ENOG4107ZI8 flagellar basal body-associated protein flil D6I95_17475 ENOG4105GSA Flagellar export protein flij D6I95_17480 ENOG4108JIR Flagellum-specific ATP synthase D6I95_17490 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) D6I95_17495 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) D6I95_17500 ENOG4105VQ0 flagellar hook-basal body complex protein fliE D6I95_17505 ENOG4105D00 flagellar biosynthetic protein flhB D6I95_17520 ENOG4105MQ3 flagellar protein FliS D6I95_17525 ENOG4105DTS flagellar hook-associated D6I95_17530 ENOG41063QE flagellar protein FlaG D6I95_17535 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) D6I95_17545 ENOG4105I03 Flagellin D6I95_17560 ENOG4106BRA Membrane D6I95_17565 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor D6I95_17570 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor D6I95_17580 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase D6I95_17595 ENOG4105CY2 Citrate transporter D6I95_17610 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) D6I95_17655 ENOG4105MQ5 zona occludens toxin D6I95_17665 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein D6I95_17685 ENOG4105YES addiction module antidote protein D6I95_17690 ENOG4105VUH addiction module killer protein D6I95_17695 ENOG4105CHR reductase D6I95_17700 ENOG4105ETT transcriptional Regulator, LysR family D6I95_17725 ENOG4105CG6 trap dicarboxylate transporter dctm subunit D6I95_17730 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA D6I95_17745 ENOG4105PE1 Receptor D6I95_17750 ENOG4105CA0 peroxidase D6I95_17760 ENOG4105CG6 trap dicarboxylate transporter dctm subunit D6I95_17770 ENOG4105D64 Mechanosensitive ion channel D6I95_17775 ENOG4105C85 amino acid D6I95_17780 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity)