locus-tag class description AFA_00010 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) AFA_00015 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) AFA_00020 ENOG4105I08 Pseudouridine synthase AFA_00050 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) AFA_00065 ENOG4105CG6 trap dicarboxylate transporter dctm subunit AFA_00085 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase AFA_00100 ENOG4105CH5 extracellular solute-binding protein, family 7 AFA_00110 ENOG4105C32 Amino acid ABC transporter (Permease) AFA_00115 ENOG4105CF8 branched-chain amino acid ABC transporter, permease AFA_00120 ENOG4108IV0 ABC, transporter AFA_00125 ENOG4105CEY Amp-dependent synthetase and ligase AFA_00135 ENOG4107TTQ Alpha beta hydrolase fold AFA_00140 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family AFA_00165 ENOG4108Q5Y Membrane AFA_00170 ENOG4105CVI Transcriptional regulator AFA_00180 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) AFA_00190 ENOG4105CHM Aminotransferase AFA_00200 ENOG4105CKI cobalamin synthesis protein AFA_00260 ENOG4108SY4 MarR family Transcriptional regulator AFA_00280 ENOG4105ERH Fumarylacetoacetate hydrolase AFA_00285 ENOG4105ES4 Nitrilase AFA_00290 ENOG4106IPI cyclase, family AFA_00295 ENOG4105E3J oxidoreductase AFA_00300 ENOG4105FUY alpha subunit AFA_00325 ENOG4105CHR reductase AFA_00345 ENOG4105CG6 trap dicarboxylate transporter dctm subunit AFA_00365 ENOG41061TZ Short-chain dehydrogenase reductase Sdr AFA_00390 ENOG4105EW6 flavin reductase domain protein, FMN-binding AFA_00395 ENOG4108JEH abc transporter atp-binding protein AFA_00405 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) AFA_00410 ENOG4108JQ7 (ABC) transporter AFA_00415 ENOG4105C3U ABC transporter AFA_00420 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component AFA_00425 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component AFA_00430 ENOG4105DEF Extracellular solute-binding protein, family 5 AFA_00435 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) AFA_00440 ENOG4108SF5 RNA Polymerase AFA_00445 ENOG4108S3W Anti-feci sigma factor, fecr AFA_00450 ENOG4105E0K tonB-dependent siderophore receptor AFA_00455 ENOG4105FQP Beta-lactamase AFA_00460 ENOG4105C8Y Acetylornithine aminotransferase AFA_00475 ENOG4105D01 (LipO)protein AFA_00480 ENOG4105D01 (LipO)protein AFA_00485 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) AFA_00490 ENOG4108UMI ABC transporter, permease AFA_00495 ENOG4107T8P acyl-Coa dehydrogenase AFA_00510 ENOG4105D01 (LipO)protein AFA_00520 ENOG4105D01 (LipO)protein AFA_00535 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) AFA_00540 ENOG4108UZX fmn reductase AFA_00560 ENOG4105ETT transcriptional Regulator, LysR family AFA_00565 ENOG4107XWS modD protein AFA_00570 ENOG4105E0C molybdate abc transporter AFA_00580 ENOG4107QP3 malate synthase g AFA_00590 ENOG4105FYV Amp nucleosidase AFA_00595 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit AFA_00600 ENOG4105CG6 trap dicarboxylate transporter dctm subunit AFA_00615 ENOG4105C7K acetolactate synthase AFA_00620 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit AFA_00630 ENOG4105CG6 trap dicarboxylate transporter dctm subunit AFA_00645 ENOG4105C9U ATP-dependent DNA helicase RecQ AFA_00660 ENOG4108RPN Protein smg homolog AFA_00675 ENOG4107QX3 carboxylase AFA_00680 ENOG4105CHU acetyl-coa acetyltransferase AFA_00685 ENOG4105VS7 Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation (By similarity) AFA_00690 ENOG4105C1G acyl-Coa dehydrogenase AFA_00710 ENOG4108Z33 Thiol disulfide Interchange Protein AFA_00720 ENOG4105C75 arginyL-tRNA synthetase AFA_00750 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) AFA_00760 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AFA_00770 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) AFA_00775 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) AFA_00780 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase AFA_00785 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F AFA_00790 ENOG4105CG6 trap dicarboxylate transporter dctm subunit AFA_00800 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit AFA_00805 ENOG4108UAU isochorismatase AFA_00810 ENOG4107R11 Transcriptional regulator AFA_00820 ENOG4108UQY Iron-storage protein AFA_00830 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) AFA_00835 ENOG410829K Lysine exporter protein (Lyse ygga) AFA_00840 ENOG4105C1J atp-dependent rna helicase AFA_00850 ENOG4105HA9 of methanol dehydrogenase type AFA_00865 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) AFA_00905 ENOG4105CG6 trap dicarboxylate transporter dctm subunit AFA_00920 ENOG4105DHJ ABC, transporter AFA_00940 ENOG4107YBY Hydrolase AFA_00945 ENOG4108NDG TRAP dicarboxylate AFA_00955 ENOG4105CG6 trap dicarboxylate transporter dctm subunit AFA_00990 ENOG4105RQF LysR family Transcriptional regulator AFA_00995 ENOG4105MWK D-amino acid dehydrogenase, small subunit AFA_01005 ENOG4105CGY Dna recombination protein AFA_01010 ENOG4105BZU Histidine kinase AFA_01015 ENOG4105VSY K01512 acylphosphatase EC 3.6.1.7 AFA_01035 ENOG4105D3G Pseudouridine synthase AFA_01040 ENOG4105HDK L-asparaginase AFA_01060 ENOG4108JEH abc transporter atp-binding protein AFA_01065 ENOG4105D82 Glutamate dehydrogenase AFA_01070 ENOG4105DFA alanine racemase domain protein AFA_01090 ENOG4105C0Z ABC transporter AFA_01095 ENOG4105C32 Amino acid ABC transporter (Permease) AFA_01110 ENOG4108IV0 ABC, transporter AFA_01120 ENOG4107QXX ABC transporter AFA_01130 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase AFA_01135 ENOG4105C79 DNA protecting protein DprA AFA_01140 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) AFA_01145 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) AFA_01165 ENOG4105CG6 trap dicarboxylate transporter dctm subunit AFA_01180 ENOG4105CFM UPF0317 protein AFA_01185 ENOG4105SKE transcriptional Regulator LysR family AFA_01190 ENOG4105D16 lipopolysaccharide heptosyltransferase i AFA_01195 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase AFA_01200 ENOG4105VEQ Cold shock protein AFA_01205 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase AFA_01210 ENOG4108194 Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) AFA_01215 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase AFA_01225 ENOG4105DZ1 carboxypeptidase AFA_01230 ENOG4105F0I Aminotransferase AFA_01235 ENOG4108Z43 UPF0250 protein AFA_01240 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) AFA_01245 ENOG4105E39 Enoyl-CoA hydratase AFA_01250 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) AFA_01260 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) AFA_01310 ENOG4105CFP Peptidase U32 AFA_01320 ENOG4105XPQ lipid carrier protein AFA_01345 ENOG4105DK0 Indole-3-glycerol phosphate synthase AFA_01350 ENOG4108I0Q anthranilate phosphoribosyltransferase AFA_01355 ENOG4105DDQ anthranilate synthase AFA_01365 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) AFA_01375 ENOG4105DJV ribulose-phosphate 3-epimerase AFA_01380 ENOG4105NWN ApaG protein AFA_01390 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family AFA_01395 ENOG4105T95 Thiol disulfide interChange protein AFA_01405 ENOG4105C8Q Methyl-accepting chemotaxis AFA_01415 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase AFA_01420 ENOG4105WQI isochorismatase AFA_01425 ENOG4105E4F Isochorismate synthase AFA_01440 ENOG4105CEY Amp-dependent synthetase and ligase AFA_01445 ENOG4105WQI isochorismatase AFA_01450 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase AFA_01460 ENOG4108IV0 ABC, transporter AFA_01465 ENOG4105C0Z ABC transporter AFA_01480 ENOG4105CAD extracellular ligand-binding receptor AFA_01495 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component AFA_01530 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) AFA_01535 ENOG4105EHG Permease protein AFA_01540 ENOG4105NIV Esterase AFA_01545 ENOG4105C1J atp-dependent rna helicase AFA_01550 ENOG4105C2C drug resistance transporter, Bcr CflA AFA_01570 ENOG4105EE5 Membrane protein terC AFA_01610 ENOG4105K5X acetyltransferase AFA_01625 ENOG4107XC4 flavin reductase domain protein, FMN-binding AFA_01645 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component AFA_01660 ENOG4105RQF LysR family Transcriptional regulator AFA_01665 ENOG4105EAB amino acid AbC transporter AFA_01670 ENOG4105CDA abc transporter atp-binding protein AFA_01675 ENOG4105DRP amino acid AbC transporter AFA_01680 ENOG4105EAD ABC transporter AFA_01685 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) AFA_01690 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) AFA_01740 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) AFA_01745 ENOG4105C25 Primosomal protein n' AFA_01750 ENOG4105C4R Atp-dependent dna helicase AFA_01775 ENOG4108D7R p-hydroxycinnamoyl CoA hydratase lyase AFA_01785 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F AFA_01790 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase AFA_01810 ENOG4105UGU tonB-dependent Receptor AFA_01815 ENOG4105D9M gamma-glutamylcysteine synthetase AFA_01825 ENOG4105VJY transcriptional regulator AFA_01830 ENOG4105DWV Homoserine O-trans-acetylase AFA_01840 ENOG4105EYM Major Facilitator superfamily AFA_01845 ENOG4105EN6 Membrane AFA_01850 ENOG41067MG lrgb family AFA_01860 ENOG4105KME endoribonuclease L-psp AFA_01865 ENOG4105KME endoribonuclease L-psp AFA_01875 ENOG4108VYJ response regulator receiver protein AFA_01905 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) AFA_01910 ENOG4105EXG Transcriptional regulator AFA_01920 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) AFA_01935 ENOG4108WBT adenosyltransferase AFA_01950 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) AFA_01955 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) AFA_01965 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters AFA_01970 ENOG4105CKI cobalamin synthesis protein AFA_01975 ENOG4105MYN Zinc uptake regulation protein AFA_01980 ENOG4105DIK (ABC) transporter AFA_01985 ENOG4105CC5 ABC transporter AFA_01990 ENOG4105DSE periplasmic solute binding protein AFA_01995 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) AFA_02005 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) AFA_02010 ENOG4105D1S lipid A biosynthesis AFA_02020 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP AFA_02025 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) AFA_02030 ENOG41082T9 Membrane AFA_02035 ENOG4105SYT Methylenetetrahydrofolate reductase AFA_02045 ENOG4107SC1 transglycosylase AFA_02065 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) AFA_02070 ENOG4108VCT Sulfite exporter TauE/SafE AFA_02075 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) AFA_02080 ENOG4105C01 Dihydroxy-acid dehydratase AFA_02090 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit AFA_02100 ENOG4105CG6 trap dicarboxylate transporter dctm subunit AFA_02105 ENOG4105DV0 amidase (EC 3.5.1.4 AFA_02115 ENOG4107RA1 nh(3)-dependent nad( ) synthetase AFA_02145 ENOG4105IPI Membrane AFA_02155 ENOG4105CVR type I restriction-modification system AFA_02165 ENOG4105DZR Type I site-specific deoxyribonuclease AFA_02195 ENOG4105GVJ transcriptional regulator AFA_02210 ENOG4105CXG d-lactate dehydrogenase AFA_02220 ENOG41073TP transcriptional regulator AFA_02225 ENOG4105DAA L-lactate AFA_02235 ENOG4105CZE histidine utilization repressor AFA_02240 ENOG4105F7P transcriptional regulator AsnC family AFA_02250 ENOG4105C85 amino acid AFA_02255 ENOG4105EFZ amidohydrolase AFA_02260 ENOG4105E98 transcriptional regulator DeoR family AFA_02265 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) AFA_02270 ENOG4105BZ7 extracellular solute-binding protein family 1 AFA_02280 ENOG4105DRS transport system, permease AFA_02295 ENOG4108ZCF integral membrane protein AFA_02300 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) AFA_02310 ENOG4108UPT UPF0178 protein AFA_02320 ENOG4105EST Metal Dependent Phosphohydrolase AFA_02330 ENOG4105CXK mandelate racemase muconate lactonizing AFA_02335 ENOG4105VEJ Heat shock protein AFA_02345 ENOG41064MX Tetr family transcriptional regulator AFA_02355 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) AFA_02365 ENOG4107RSM transcriptional regulator AFA_02390 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) AFA_02395 ENOG4108ESX Receptor AFA_02400 ENOG4107E2E PKHD-type hydroxylase AFA_02425 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY AFA_02435 ENOG4109066 lysm domain bon superfamily protein AFA_02440 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) AFA_02450 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) AFA_02490 ENOG4105CBN LysR family transcriptional regulator AFA_02495 ENOG4105EWV Sodium calcium exchanger membrane region AFA_02500 ENOG4105BZU Histidine kinase AFA_02510 ENOG4105CSH Transporter AFA_02515 ENOG4108S8N class II Aldolase AFA_02525 ENOG4108NS2 receptor AFA_02530 ENOG4107Y2X deaminase AFA_02535 ENOG4105S0E allantoin catabolism protein AFA_02540 ENOG4108M0I Transcriptional regulator AFA_02550 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) AFA_02560 ENOG4105D1F ATP-binding protein AFA_02575 ENOG4105DHP deoxycytidine triphosphate deaminase AFA_02580 ENOG4105CXN decarboxylase AFA_02585 ENOG4105CBX hi0933 family AFA_02590 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) AFA_02600 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) AFA_02605 ENOG4108UKZ OsmC family AFA_02610 ENOG4105EUH cytochrome C oxidase, cbb3-type, subunit i AFA_02635 ENOG4108S0N Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol (By similarity) AFA_02640 ENOG4105CA9 Pyruvate kinase AFA_02645 ENOG4108ZJF Glcg protein AFA_02655 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase AFA_02660 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) AFA_02665 ENOG41060W2 glyoxylate carboligase AFA_02670 ENOG4105EJC lysr family transcriptional regulator AFA_02680 ENOG4105C2W permease AFA_02685 ENOG41084KP 4-oxalocrotonate tautomerase AFA_02690 ENOG4105MP9 class II Aldolase AFA_02700 ENOG4105FFA Catalyzes the oxidation of uric acid to 5- hydroxyisourate, which is further processed to form (S)-allantoin (By similarity) AFA_02710 ENOG4107UKG Glycosyl transferase, family 4 AFA_02715 ENOG4107QQG Dehydrogenase AFA_02730 ENOG4105CG5 Glycosyl transferase (Group 1 AFA_02735 ENOG4107XU6 Glycosyl transferase (Group 1 AFA_02740 ENOG4105CGN Glycosyl transferase (Group 1 AFA_02750 ENOG4105CQB FAD linked oxidase domain protein AFA_02760 ENOG4105ERH Fumarylacetoacetate hydrolase AFA_02765 ENOG4105F1J Homogentisate 1,2-dioxygenase AFA_02775 ENOG4105E2Q 3-(3-hydroxy-phenyl)propionate hydroxylase AFA_02785 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) AFA_02795 ENOG41081V9 Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein (By similarity) AFA_02810 ENOG4105C5T Phosphoribosyl pyrophosphate synthase AFA_02815 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) AFA_02820 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) AFA_02830 ENOG4105C3G gtp-binding protein AFA_02835 ENOG4106B0W Curli production assembly transport component CsgG AFA_02845 ENOG4107Y60 (LipO)protein AFA_02855 ENOG4108594 Permease of the drug metabolite transporter AFA_02860 ENOG4105C5H ABC transporter AFA_02870 ENOG4107B2H carbonic anhydrase AFA_02875 ENOG4105DND Transcriptional regulator AFA_02890 ENOG4105CA5 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity) AFA_02895 ENOG41060IM Heme exporter protein AFA_02905 ENOG4108ZKK Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH (By similarity) AFA_02910 ENOG4105DA4 cytochrome c-type biogenesis protein AFA_02915 ENOG4107QX9 Thiol disulfide interChange protein AFA_02920 ENOG4105KWW Biogenesis protein AFA_02925 ENOG4108M1T Cytochrome c-type biogenesis protein AFA_02930 ENOG4107QIV Cytochrome c biogenesis protein AFA_02935 ENOG4107EXU Short-chain dehydrogenase reductase Sdr AFA_02940 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) AFA_02960 ENOG4105C32 Amino acid ABC transporter (Permease) AFA_02965 ENOG4105CF8 branched-chain amino acid ABC transporter, permease AFA_02970 ENOG4105C0Z ABC transporter AFA_02975 ENOG4108IV0 ABC, transporter AFA_02980 ENOG4105CA0 peroxidase AFA_02985 ENOG4108JQ1 Dehydrogenase AFA_02990 ENOG4105KPV Transcriptional regulator AFA_02995 ENOG4105VIG Sec-independent protein translocase protein TatC AFA_03035 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) AFA_03040 ENOG4108IEG Formate dehydrogenase Alpha subunit AFA_03045 ENOG4107QIZ NADH dehydrogenase AFA_03060 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) AFA_03065 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) AFA_03070 ENOG4105CVM Molybdenum cofactor synthesis domain protein AFA_03075 ENOG4108RIR Molybdenum cofactor biosynthesis protein AFA_03080 ENOG4108ZAF Molybdopterin AFA_03090 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) AFA_03095 ENOG4108ZXC Two component transcriptional regulator, luxr family AFA_03100 ENOG4105BZU Histidine kinase AFA_03105 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit AFA_03110 ENOG4108RA0 tripartite ATP-independent periplasmic transporter, DctQ component AFA_03115 ENOG4105CG6 trap dicarboxylate transporter dctm subunit AFA_03130 ENOG4108TZV Membrane AFA_03135 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) AFA_03155 ENOG410624X efflux transporter, rnd family, mfp subunit AFA_03195 ENOG4105BZU Histidine kinase AFA_03200 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) AFA_03205 ENOG4108JU5 Magnesium and cobalt efflux protein AFA_03210 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) AFA_03215 ENOG4105C9A Phoh family AFA_03220 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) AFA_03230 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) AFA_03235 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) AFA_03240 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) AFA_03245 ENOG4105VIE preprotein translocase, subunit YajC AFA_03250 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) AFA_03255 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) AFA_03260 ENOG4106HRJ d-alanyl-d-alanine carboxypeptidase AFA_03265 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) AFA_03275 ENOG4105NE1 Conserved Protein AFA_03290 ENOG4105ETT transcriptional Regulator, LysR family AFA_03305 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase AFA_03320 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) AFA_03330 ENOG4105CSH Transporter AFA_03345 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) AFA_03355 ENOG4105CHM Aminotransferase AFA_03365 ENOG4105C6K Malic enzyme AFA_03375 ENOG41067XF inhibitor AFA_03380 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) AFA_03385 ENOG4105CV1 Transketolase (EC 2.2.1.1) AFA_03390 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase AFA_03395 ENOG4105BZA Phosphoglycerate kinase AFA_03420 ENOG4108RIR Molybdenum cofactor biosynthesis protein AFA_03430 ENOG4105C8V SAICAR synthetase AFA_03435 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) AFA_03440 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit AFA_03445 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) AFA_03450 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) AFA_03460 ENOG4105DXM phenylacetic acid degradation protein AFA_03465 ENOG4105C1G acyl-Coa dehydrogenase AFA_03470 ENOG4108MGI Transcriptional regulator AFA_03475 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) AFA_03485 ENOG4105D5U fad dependent oxidoreductase AFA_03495 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) AFA_03505 ENOG4105CUZ uba thif-type nad fad binding protein AFA_03515 ENOG4105CRQ synthase (Component I) AFA_03520 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) AFA_03530 ENOG4108SHN Glycosyl transferase, family 2 AFA_03540 ENOG4105C5H ABC transporter AFA_03560 ENOG4105VJP Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity) AFA_03565 ENOG4107QMS site-determining protein AFA_03575 ENOG4105CX6 glutaminyL-tRNA synthetase AFA_03585 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii AFA_03600 ENOG4105C9U ATP-dependent DNA helicase RecQ AFA_03605 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) AFA_03610 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) AFA_03615 ENOG4105XPH Ferredoxin AFA_03620 ENOG4105C5H ABC transporter AFA_03630 ENOG4108V6E Cell division protein mraZ AFA_03635 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) AFA_03640 ENOG4105N8N Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) AFA_03645 ENOG4105CJN penicillin-binding protein AFA_03650 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) AFA_03655 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) AFA_03660 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) AFA_03670 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) AFA_03675 ENOG4105DFU Cell wall formation (By similarity) AFA_03680 ENOG4105CPF Cell wall formation (By similarity) AFA_03685 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) AFA_03690 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) AFA_03695 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) AFA_03700 ENOG4105C7C involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) AFA_03710 ENOG4105E4C Lytic transglycosylase catalytic AFA_03715 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving AFA_03725 ENOG4105CJW magnesium transporter AFA_03730 ENOG4105NAU thioesterase Superfamily protein AFA_03735 ENOG4105CH2 amidohydrolase AFA_03740 ENOG4105CEY Amp-dependent synthetase and ligase AFA_03745 ENOG4105ECY inositol monophosphatase AFA_03750 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) AFA_03765 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) AFA_03770 ENOG4108UMI ABC transporter, permease AFA_03775 ENOG4105D01 (LipO)protein AFA_03780 ENOG4107R0W ABC transporter AFA_03785 ENOG4105E5Q amino acid AbC transporter AFA_03790 ENOG4105CDA abc transporter atp-binding protein AFA_03800 ENOG4108S0S Nucleotidyl transferase AFA_03805 ENOG4105EHM Aminoglycoside phosphotransferase AFA_03815 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) AFA_03820 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) AFA_03840 ENOG4105E9Q Acyl-transferase AFA_03845 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase AFA_03850 ENOG4105C38 Glycyl-tRNA synthetase beta subunit AFA_03855 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit AFA_03865 ENOG4105E39 Enoyl-CoA hydratase AFA_03870 ENOG4107GFK fumarate AFA_03875 ENOG4108IG5 Transcriptional regulator AFA_03885 ENOG4105F27 Major Facilitator AFA_03900 ENOG4105DJ0 Poly(A) Polymerase AFA_03910 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) AFA_03915 ENOG4105CXB phosphoribosylaminoimidazole synthetase AFA_03920 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease AFA_03925 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) AFA_03930 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) AFA_03935 ENOG4105DQR SNARE associated Golgi AFA_03940 ENOG4105CJ2 (LipO)protein AFA_03960 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase AFA_03965 ENOG4105K8N protein family UPF0079, ATPase AFA_03980 ENOG4105C6K Malic enzyme AFA_03985 ENOG4105DDW LysR family Transcriptional regulator AFA_03990 ENOG4105C26 Dehydrogenase AFA_03995 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) AFA_04005 ENOG4105CG6 trap dicarboxylate transporter dctm subunit AFA_04030 ENOG4105KVH Transcriptional regulator AFA_04035 ENOG4108RYK Nad-dependent epimerase dehydratase AFA_04050 ENOG4108Z66 YbaK ebsC protein AFA_04055 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) AFA_04060 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein AFA_04065 ENOG4105E0C molybdate abc transporter AFA_04070 ENOG4108IJ6 ABC transporter AFA_04075 ENOG4105F4R Transcriptional regulator mode AFA_04085 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation AFA_04095 ENOG4107QMP dna polymerase iii subunits gamma and tau AFA_04105 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) AFA_04110 ENOG4107BVJ 4,5-dihydroxyphthalate decarboxylase AFA_04120 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component AFA_04125 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) AFA_04130 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain AFA_04135 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain AFA_04150 ENOG4105CVJ phosphoglycerate mutase AFA_04155 ENOG4105C2W permease AFA_04160 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) AFA_04165 ENOG4105HBR Rna-binding protein AFA_04170 ENOG4105F7M Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity) AFA_04175 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) AFA_04180 ENOG4105EEI dihydropteroate synthase AFA_04185 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) AFA_04195 ENOG4105C9X ppx gppa phosphatase AFA_04200 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) AFA_04205 ENOG4107QMV Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) AFA_04210 ENOG4105C8U phosphate abc transporter AFA_04215 ENOG4105E2Z phosphate ABC transporter (Permease AFA_04220 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) AFA_04225 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) AFA_04240 ENOG4105XJC Two component transcriptional regulator (Winged helix family AFA_04245 ENOG4105JJR Histidine kinase AFA_04255 ENOG4105F87 Dehydratase AFA_04260 ENOG4105GZI Transcriptional regulator AFA_04280 ENOG4105E0M Sulfatase AFA_04310 ENOG4107QN1 sodium solute AFA_04315 ENOG4105V9J phenylacetic acid degradation operon negative regulatory protein AFA_04320 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) AFA_04335 ENOG4107RTD sua5 ycio yrdc ywlc family protein AFA_04340 ENOG4108Z4T Peptidase M50 AFA_04345 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) AFA_04350 ENOG4105GJM (LipO)protein AFA_04365 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) AFA_04375 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) AFA_04380 ENOG4106A3M Cytochrome p-450 AFA_04385 ENOG4105DKK Benzoate AFA_04390 ENOG4105EZE Cupin 4 family protein AFA_04395 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) AFA_04400 ENOG4108NS2 receptor AFA_04415 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) AFA_04420 ENOG4105ENJ RND efflux system, outer membrane lipoprotein AFA_04425 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) AFA_04430 ENOG4105BZ1 (ABC) transporter AFA_04435 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) AFA_04450 ENOG4105DEN Luciferase family AFA_04460 ENOG4105D64 Mechanosensitive ion channel AFA_04465 ENOG4108K70 Transcriptional regulator AFA_04505 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) AFA_04510 ENOG4105CRW Short chain fatty acid transporter AFA_04525 ENOG4105ECY inositol monophosphatase AFA_04530 ENOG4105EE5 Membrane protein terC AFA_04535 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) AFA_04540 ENOG4105F10 Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity) AFA_04555 ENOG4105C8N cysteinyl-tRNA synthetase AFA_04565 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) AFA_04570 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) AFA_04575 ENOG4105CFH Aspartokinase AFA_04590 ENOG4105EPW hflc protein AFA_04600 ENOG4107S4Z Activates expression of the rhaBAD and rhaT operons (By similarity) AFA_04630 ENOG4105ECW sulfate abc transporter AFA_04635 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) AFA_04640 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) AFA_04645 ENOG4105W8H transhydrogenase (subunit alpha AFA_04650 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) AFA_04675 ENOG4105DMF Dehydrogenase AFA_04680 ENOG4105CHF Glutathione S-transferase AFA_04685 ENOG4105CS1 NAD(P)H quinone oxidoreductase AFA_04700 ENOG4108VX5 3-methyladenine DNA glycosylase AFA_04705 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) AFA_04715 ENOG4105D7N magnesium and cobalt transport protein CorA AFA_04720 ENOG4105CSU acyl-Coa dehydrogenase AFA_04730 ENOG4105DEF Extracellular solute-binding protein, family 5 AFA_04740 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component AFA_04745 ENOG4108JQ6 ABC transporter AFA_04755 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family AFA_04760 ENOG4105C26 Dehydrogenase AFA_04765 ENOG4105C0A alcohol dehydrogenase AFA_04770 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) AFA_04785 ENOG4105CG6 trap dicarboxylate transporter dctm subunit AFA_04785 ENOG4105CG6 trap dicarboxylate transporter dctm subunit AFA_04795 ENOG4105CH5 extracellular solute-binding protein, family 7 AFA_04800 ENOG4107QIJ Aconitate hydratase 2 AFA_04815 ENOG4105BZN citrate synthase AFA_04820 ENOG4105CR4 methylisocitrate lyase AFA_04825 ENOG4108JU7 Transcriptional regulator AFA_04840 ENOG4105D9Z Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) AFA_04845 ENOG4105FDP GntR family transcriptional regulator AFA_04850 ENOG4108UTY succinate dehydrogenase, cytochrome b556 subunit AFA_04865 ENOG4105E33 succinate dehydrogenase AFA_04870 ENOG41060IS Flavinator of succinate dehydrogenase AFA_04875 ENOG4105BZN citrate synthase AFA_04880 ENOG41073TP transcriptional regulator AFA_04885 ENOG4105DAA L-lactate AFA_04890 ENOG4105C6K Malic enzyme AFA_04895 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 AFA_04900 ENOG4105C7S Dehydrogenase AFA_04905 ENOG4107QN2 dihydrolipoyl dehydrogenase AFA_04910 ENOG4105D6Z AFG1 family ATPase AFA_04915 ENOG4105C31 Tryptophanyl-tRNA synthetase AFA_04930 ENOG4105BZM domain protein AFA_04935 ENOG4105DVT helicase AFA_04940 ENOG4105CHH sulfate transporter AFA_04945 ENOG4105NDK ethanolamine utilization protein AFA_04950 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) AFA_04965 ENOG4105CG6 trap dicarboxylate transporter dctm subunit AFA_04980 ENOG4105C34 Pseudouridine synthase AFA_04985 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase AFA_04990 ENOG4105D1N poly(r)-hydroxyalkanoic acid synthase, class AFA_04995 ENOG4105CHR reductase AFA_05000 ENOG4108NVM synthesis repressor PhaR AFA_05025 ENOG4105KUS lysozyme AFA_05085 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) AFA_05090 ENOG4105FE9 pseudouridine synthase AFA_05095 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) AFA_05100 ENOG4105CHV Transcription elongation factor NusA AFA_05110 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) AFA_05115 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) AFA_05125 ENOG4107SA8 fad-dependent pyridine nucleotide-disulfide oxidoreductase AFA_05135 ENOG4106YG3 ABC transporter AFA_05140 ENOG4105DSP amino acid AbC transporter AFA_05145 ENOG4105E89 ABC transporter AFA_05150 ENOG4108URH decarboxylase AFA_05155 ENOG4105C2M dna polymerase I AFA_05160 ENOG4105EAM Na Pi-cotransporter AFA_05165 ENOG4105D0M Protease HtpX homolog AFA_05175 ENOG4105KHC sulfurtransferase AFA_05180 ENOG41082UU Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) AFA_05185 ENOG4105CTB Polyprenyl synthetase AFA_05190 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) AFA_05195 ENOG4105DZA Converts GTP to 7,8-dihydroneopterin triphosphate (By similarity) AFA_05200 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) AFA_05210 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) AFA_05215 ENOG4105K9Q Binds to the 23S rRNA (By similarity) AFA_05220 ENOG4105CDU Replicative dna helicase AFA_05225 ENOG4105DHU Bile acid AFA_05230 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) AFA_05235 ENOG4108IAB Phoh family AFA_05240 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen AFA_05250 ENOG4105CHM Aminotransferase AFA_05255 ENOG4105D6E homoserine dehydrogenase AFA_05270 ENOG4108MK9 spermidine N(1)-acetyltransferase AFA_05275 ENOG4105CVN desaturase AFA_05290 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) AFA_05295 ENOG4105CHR reductase AFA_05300 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) AFA_05320 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) AFA_05325 ENOG4105F38 ABC transporter, permease AFA_05330 ENOG4105D38 putrescine abc transporter AFA_05340 ENOG4105E66 phosphoriboisomerase A AFA_05345 ENOG4108UTW Plays a role in the regulation of phosphate uptake AFA_05355 ENOG4105KMG Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes (By similarity) AFA_05360 ENOG4108EKC n-acetylglutamate synthase AFA_05365 ENOG4105CQ7 ATP-dependent helicase AFA_05370 ENOG4105C0B DNA polymerase III (alpha subunit) AFA_05375 ENOG4105CPK Glycosyl transferase (Group 1 AFA_05380 ENOG4107BJW polysaccharide deacetylase AFA_05385 ENOG4106WTF Glycosyl transferase, family 2 AFA_05395 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) AFA_05405 ENOG4105KRS Proteinase inhibitor AFA_05420 ENOG4105BZ1 (ABC) transporter AFA_05435 ENOG4105C03 ribonuclease AFA_05470 ENOG4105CJP fad dependent oxidoreductase AFA_05480 ENOG4105DUM transcriptional regulator, lysR family AFA_05490 ENOG4108KWP DNA-binding transcriptional regulator GlcC AFA_05495 ENOG4105CQB FAD linked oxidase domain protein AFA_05500 ENOG4105EU8 FAD linked oxidase domain protein AFA_05505 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) AFA_05525 ENOG4105GAK amidohydrolase 2 AFA_05535 ENOG4105KHM amidohydrolase 2 AFA_05540 ENOG4105D2S major facilitator superfamily AFA_05550 ENOG4105EF7 Transcriptional regulator AFA_05555 ENOG4105C0R drug resistance transporter emrb qaca subfamily AFA_05580 ENOG41072AC 4-hydroxybenzoate 3-monooxygenase AFA_05610 ENOG4108REF Sporulation integral membrane protein ytvi AFA_05630 ENOG4108Z9W Outer membrane porin AFA_05640 ENOG4106UX7 integral membrane protein AFA_05650 ENOG4105DUM transcriptional regulator, lysR family AFA_05660 ENOG4108YY7 Invasion gene expression up-regulator SirB AFA_05670 ENOG41080HT Transcriptional regulator, arsr family AFA_05695 ENOG4105CHH sulfate transporter AFA_05700 ENOG4105E6M Sulphatase-modifying factor protein AFA_05705 ENOG4107QRH Arylsulfatase (Ec 3.1.6.1) AFA_05710 ENOG4105YB8 TM2 domain containing protein AFA_05715 ENOG4107QVN Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) AFA_05720 ENOG4105C6V Glycerol-3-phosphate dehydrogenase AFA_05725 ENOG4105K4H Nlp p60 protein AFA_05730 ENOG4105GEH Functions in complex with FlhC as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region. Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes. Also regulates genes whose products function in a variety of physiological pathways (By similarity) AFA_05735 ENOG4106CIA Functions in complex with FlhD as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region AFA_05740 ENOG4107RD7 Flagellar Motor Protein, MotA AFA_05745 ENOG4105ER2 Ompa motb domain protein AFA_05750 ENOG4105CBS Chea signal transduction histidine kinase AFA_05755 ENOG4108V3W Chemotaxis protein, CheW AFA_05760 ENOG4105C8Q Methyl-accepting chemotaxis AFA_05765 ENOG4105BZU Histidine kinase AFA_05775 ENOG4108VYJ response regulator receiver protein AFA_05780 ENOG4108KCC Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P) (By similarity) AFA_05785 ENOG4105D00 flagellar biosynthetic protein flhB AFA_05790 ENOG4105D7B Flagellar biosynthesis protein flha AFA_05795 ENOG4105FZW flagellar biosynthesis regulator FlhF AFA_05800 ENOG4105CAF HipA N-terminal domain protein AFA_05815 ENOG4105M9M anti-sigma28 factor FlgM AFA_05825 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) AFA_05830 ENOG4108ZC9 flagellar basal-body rod protein flgc AFA_05835 ENOG4105W00 Flagellar hook capping protein AFA_05840 ENOG4105BZE flagellar hook protein, FlgE AFA_05845 ENOG4108KPB Flagellar basal-body rod protein FlgF AFA_05850 ENOG4105CGA flagellar basal-body rod protein FlgG AFA_05860 ENOG4105D92 Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) AFA_05865 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj AFA_05870 ENOG4105E1Q flagellar hook-associated protein AFA_05875 ENOG4105DTJ flagellar hook-associated protein AFA_05880 ENOG4105C8Q Methyl-accepting chemotaxis AFA_05890 ENOG4105C8Q Methyl-accepting chemotaxis AFA_05905 ENOG4105D19 Role in flagellar biosynthesis (By similarity) AFA_05910 ENOG4105VS8 Flagellar biosynthetic protein fliq AFA_05915 ENOG4105CN7 Flagellar biosynthetic protein FliP AFA_05925 ENOG4105DD5 Flagellar motor switch protein AFA_05930 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) AFA_05935 ENOG4107ZI8 flagellar basal body-associated protein flil AFA_05945 ENOG4105GSA Flagellar export protein flij AFA_05950 ENOG4108JIR Flagellum-specific ATP synthase AFA_05960 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) AFA_05965 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) AFA_05970 ENOG4105VQ0 flagellar hook-basal body complex protein fliE AFA_05975 ENOG4105D00 flagellar biosynthetic protein flhB AFA_05990 ENOG4105MQ3 flagellar protein FliS AFA_05995 ENOG4105DTS flagellar hook-associated AFA_06000 ENOG41063QE flagellar protein FlaG AFA_06005 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AFA_06015 ENOG4105I03 Flagellin AFA_06050 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) AFA_06060 ENOG4105E6M Sulphatase-modifying factor protein AFA_06080 ENOG4106BRA Membrane AFA_06085 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor AFA_06090 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor AFA_06100 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase AFA_06115 ENOG4105CY2 Citrate transporter AFA_06125 ENOG4105CHR reductase AFA_06130 ENOG4105ETT transcriptional Regulator, LysR family AFA_06135 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA AFA_06150 ENOG4105PE1 Receptor AFA_06155 ENOG4105CA0 peroxidase AFA_06160 ENOG4105C0A alcohol dehydrogenase AFA_06170 ENOG4105CG6 trap dicarboxylate transporter dctm subunit AFA_06180 ENOG4105D64 Mechanosensitive ion channel AFA_06185 ENOG4105C85 amino acid AFA_06190 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) AFA_06230 ENOG4107S7U Sulfide dehydrogenase AFA_06255 ENOG4105VEQ Cold shock protein AFA_06280 ENOG4105D9P serine threonine protein kinase AFA_06375 ENOG4105DHQ Histidine kinase AFA_06380 ENOG4105XJC Two component transcriptional regulator (Winged helix family AFA_06385 ENOG4105EUH cytochrome C oxidase, cbb3-type, subunit i AFA_06395 ENOG41090Y2 cytochrome C AFA_06400 ENOG4105NQN cytochrome C AFA_06405 ENOG4108R1E Serine threonine protein phosphatase 1 AFA_06410 ENOG4105E0K tonB-dependent siderophore receptor AFA_06450 ENOG4105J12 Multidrug resistance protein mdtN AFA_06455 ENOG4105EM2 membrane AFA_06460 ENOG4105C7N Xanthine uracil vitamin C permease AFA_06465 ENOG41083B3 HAD-superfamily subfamily IB hydrolase AFA_06490 ENOG4105CBC glutamate synthase AFA_06500 ENOG4108SY4 MarR family Transcriptional regulator AFA_06505 ENOG4105CEV competence damage-inducible protein AFA_06510 ENOG4108I0Z Aconitate hydratase AFA_06550 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr AFA_06560 ENOG4107SG5 Dehydrogenase AFA_06565 ENOG4105CHR reductase AFA_06575 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) AFA_06585 ENOG4105EGS Mechanosensitive ion channel AFA_06590 ENOG4105EGS Mechanosensitive ion channel AFA_06595 ENOG4105CSH Transporter AFA_06610 ENOG4108IMY Transcriptional regulator AFA_06615 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase AFA_06620 ENOG4105BZU Histidine kinase AFA_06625 ENOG4105CJW magnesium transporter AFA_06635 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) AFA_06640 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) AFA_06655 ENOG4108W0I acetyltransferase AFA_06660 ENOG4105K5B UPF0225 protein AFA_06665 ENOG4108K0D peptidase, M48 AFA_06985 ENOG4105KUS lysozyme AFA_07005 ENOG4108RAV Conserved protein AFA_07030 ENOG4105UPP uncharacterized protein ydcA AFA_07155 ENOG4105KUS lysozyme AFA_07210 ENOG4105BZU Histidine kinase AFA_07225 ENOG4108XM1 transcriptional regulator AsnC family AFA_07230 ENOG4105C28 cystathionine AFA_07240 ENOG4105M6F mutator MutT protein AFA_07245 ENOG4105WD1 Membrane AFA_07255 ENOG4105CDH Citrulline--aspartate ligase AFA_07260 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) AFA_07265 ENOG4108IJ6 ABC transporter AFA_07285 ENOG4105ETE Transcriptional regulator (LacI family AFA_07290 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) AFA_07300 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) AFA_07310 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) AFA_07315 ENOG4105C08 Histidine kinase AFA_07320 ENOG4105EEX Two component transcriptional regulator (Winged helix family AFA_07325 ENOG4105DBV ornithine carbamoyltransferase AFA_07335 ENOG4105C5I Dehydrogenase AFA_07340 ENOG41082GY Binds directly to 16S ribosomal RNA (By similarity) AFA_07345 ENOG4105CJR Integral membrane protein (MviN AFA_07355 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) AFA_07360 ENOG4105CET Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) AFA_07365 ENOG4105W49 UPF0434 protein AFA_07370 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) AFA_07375 ENOG4105M8F Biopolymer transport protein exbD tolR AFA_07385 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) AFA_07390 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) AFA_07395 ENOG4108UWD Iron-storage protein AFA_07400 ENOG4105CHU acetyl-coa acetyltransferase AFA_07410 ENOG4105VEQ Cold shock protein AFA_07415 ENOG4105KAE Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) AFA_07420 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit AFA_07425 ENOG4105F1S paraquat-inducible protein a AFA_07430 ENOG4105DY2 Paraquat-inducible protein b AFA_07450 ENOG4105C32 Amino acid ABC transporter (Permease) AFA_07455 ENOG4105CF8 branched-chain amino acid ABC transporter, permease AFA_07460 ENOG4105C0Z ABC transporter AFA_07465 ENOG4108IV0 ABC, transporter AFA_07495 ENOG4105EBA Specifically methylates the adenine in position 1618 of 23S rRNA (By similarity) AFA_07500 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) AFA_07505 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase AFA_07510 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) AFA_07515 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) AFA_07520 ENOG4105DTN riboflavin biosynthesis protein ribF AFA_07525 ENOG4108V3E phosphoribosylglycinamide formyltransferase AFA_07540 ENOG4105C4R Atp-dependent dna helicase AFA_07565 ENOG4105C5H ABC transporter AFA_07570 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) AFA_07575 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) AFA_07580 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) AFA_07590 ENOG4105R1U AraC Family Transcriptional Regulator AFA_07645 ENOG4108Z4X TRANSCRIPTIONal AFA_07665 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F AFA_07670 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation AFA_07675 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) AFA_07680 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) AFA_07685 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) AFA_07695 ENOG4108428 Inherit from COG: -acetyltransferase AFA_07700 ENOG4105CGF Aromatic amino acid aminotransferase AFA_07705 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) AFA_07715 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family AFA_07720 ENOG4105C3J Cysteine desulfurase AFA_07725 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins AFA_07730 ENOG4108Z4V iron-sulfur cluster assembly AFA_07745 ENOG4105CRK lysyL-tRNA synthetase AFA_07750 ENOG4105PDP Short chain dehydrogenase AFA_07760 ENOG4105C8Q Methyl-accepting chemotaxis AFA_07765 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) AFA_07770 ENOG4108IPJ Membrane AFA_07775 ENOG4105C09 Bile acid AFA_07785 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) AFA_07800 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) AFA_07805 ENOG4105EYA deoxyribonuclease AFA_07810 ENOG4108EC8 DNA internalization-related competence protein ComEC AFA_07815 ENOG4108EV1 Haloalkane dehalogenase AFA_07820 ENOG4105DB7 PHP domain protein AFA_07830 ENOG4108ETH Formylglycinamide ribotide synthetase AFA_07835 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) AFA_07845 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) AFA_07905 ENOG4105D6J arsenicaL-resistance protein AFA_07945 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) AFA_07965 ENOG4105DZ2 Transcriptional regulator AFA_07995 ENOG4105CSU acyl-Coa dehydrogenase AFA_08005 ENOG4105D29 Helix-turn-helix type 11 domain protein AFA_08010 ENOG4105CKI cobalamin synthesis protein AFA_08015 ENOG4105DZA Converts GTP to 7,8-dihydroneopterin triphosphate (By similarity) AFA_08020 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) AFA_08030 ENOG4105CD3 dihydroorotase AFA_08035 ENOG41090R7 Ferric uptake AFA_08040 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase AFA_08045 ENOG4105DWF phosphomethylpyrimidine kinase AFA_08050 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) AFA_08055 ENOG41090U3 tautomerase AFA_08060 ENOG4108EGH Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) AFA_08070 ENOG4105EA8 2-Nitropropane dioxygenase AFA_08105 ENOG4105EJC lysr family transcriptional regulator AFA_08130 ENOG4108S10 Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) AFA_08150 ENOG4105WPR Transcriptional regulator, ARAC family AFA_08180 ENOG410846T CoA-transferase family III AFA_08190 ENOG4105C1G acyl-Coa dehydrogenase AFA_08215 ENOG41080HT Transcriptional regulator, arsr family AFA_08235 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) AFA_08250 ENOG410626B catechol 1,2-dioxygenase AFA_08260 ENOG4107QNJ CoA-transferase subunit B AFA_08265 ENOG4105F2Z 3-oxoadipate enol-lactonase AFA_08275 ENOG4105DKK Benzoate AFA_08280 ENOG4108MR5 AFA_08285 ENOG4108MZY AFA_08300 ENOG4108IUW ABC transporter AFA_08310 ENOG4105WH1 Two component transcriptional regulator luxr family AFA_08315 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) AFA_08345 ENOG4108VHT MarR family transcriptional regulator AFA_08350 ENOG4105MSY salicylate hydroxylase AFA_08355 ENOG4105CSP Major Facilitator Superfamily AFA_08365 ENOG4105DFA alanine racemase domain protein AFA_08370 ENOG4105CSW GntR family transcriptional regulator AFA_08375 ENOG4108KTG Membrane protein, drug metabolite transporter AFA_08385 ENOG4105F2V VRR-NUC domain-containing protein AFA_08405 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) AFA_08410 ENOG4105CPC Aldo Keto reductase AFA_08425 ENOG4108UT2 hemolysin iii AFA_08440 ENOG4105CSH Transporter AFA_08445 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) AFA_08470 ENOG4105EAB amino acid AbC transporter AFA_08475 ENOG4105E5Q amino acid AbC transporter AFA_08480 ENOG4105DRP amino acid AbC transporter AFA_08485 ENOG4105CDA abc transporter atp-binding protein AFA_08520 ENOG4105EUV Phenol 2-monooxygenase AFA_08540 ENOG4108JA0 Oxidoreductase, FAD NAD(P)-binding domain protein AFA_08545 ENOG4105DVW rieske (2Fe-2S) AFA_08580 ENOG4105D2S major facilitator superfamily AFA_08590 ENOG410829K Lysine exporter protein (Lyse ygga) AFA_08600 ENOG4105ETE Transcriptional regulator (LacI family AFA_08610 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) AFA_08630 ENOG4107QX8 SPFH domain, Band 7 family protein AFA_08635 ENOG4105G5H Membrane AFA_08640 ENOG4108D32 Methyltransferase AFA_08650 ENOG4105UCG Domain of unknown function (DUF333) AFA_08660 ENOG4108MGF sugar kinase AFA_08670 ENOG4105C22 threonyL-tRNA synthetase AFA_08675 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) AFA_08680 ENOG4105D7Z glutathione synthase AFA_08690 ENOG41080Z8 PHOSPHOCARRIER protein AFA_08695 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) AFA_08720 ENOG4105C0P Mg chelatase subunit ChlI AFA_08725 ENOG4105VJV 50s ribosomal protein L35 AFA_08730 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) AFA_08735 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) AFA_08740 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) AFA_08745 ENOG4108ZUF This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) AFA_08755 ENOG4105ED9 Protein of unknown function (DUF455) AFA_08765 ENOG4108JJ7 ABC transporter AFA_08770 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family AFA_08780 ENOG4105C3K feS assembly ATPase SufC AFA_08785 ENOG4105JRK feS assembly protein SufD AFA_08790 ENOG4105C9B Cysteine desulfurase AFA_08795 ENOG4108UNV SUF system FeS assembly protein, NifU family AFA_08800 ENOG4105VG1 fes assembly suf system protein AFA_08815 ENOG4105P8Q Curli production assembly transport component CsgG AFA_08820 ENOG4108WYR Curli production assembly transport component, CsgF AFA_08835 ENOG4105CND Glycosyl transferase, family 2 AFA_08840 ENOG4107BJW polysaccharide deacetylase AFA_08845 ENOG4108TUY outer membrane protein PgaA AFA_08860 ENOG4105VEQ Cold shock protein AFA_08895 ENOG4105HX0 Transcriptional regulator AFA_08900 ENOG4107RCH Diaminopropionate ammonia-lyase AFA_08905 ENOG4105CE7 Amidase, hydantoinase carbamoylase family AFA_08925 ENOG4108JQ6 ABC transporter AFA_08935 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) AFA_08985 ENOG4105CB2 alcohol dehydrogenase AFA_08990 ENOG41075H3 AraC family transcriptional regulator AFA_08995 ENOG4105FC8 fad dependent oxidoreductase AFA_09000 ENOG4108K88 Membrane AFA_09010 ENOG4105E6M Sulphatase-modifying factor protein AFA_09025 ENOG4105CZN Potassium uptake protein AFA_09035 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase AFA_09045 ENOG4105KTH gatB Yqey AFA_09050 ENOG4105C0B DNA polymerase III (alpha subunit) AFA_09080 ENOG4107UI5 Transforms N(2)-succinylglutamate into succinate and glutamate (By similarity) AFA_09090 ENOG4105DUM transcriptional regulator, lysR family AFA_09095 ENOG41061WM D-Alanyl-D-Alanine AFA_09105 ENOG4107R0U MotA TolQ exbB proton channel AFA_09110 ENOG4106VK6 Flagellar motor protein AFA_09120 ENOG4105CHR reductase AFA_09125 ENOG4105CPU Monooxygenase AFA_09130 ENOG4105EMU Dehydrogenase AFA_09135 ENOG4108R6K riboflavin synthase, subunit alpha AFA_09145 ENOG4108IJ0 Aspartate ammonia-lyase AFA_09150 ENOG4105CK2 sodium dicarboxylate symporter AFA_09160 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family AFA_09165 ENOG4106P55 Transcriptional regulator AFA_09170 ENOG4107EFR Flavocytochrome c AFA_09175 ENOG41079YP Citrate utilization protein b AFA_09185 ENOG4105DB1 molybdopterin oxidoreductase AFA_09190 ENOG4106WHD Tetrathionate reductase AFA_09195 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein AFA_09200 ENOG4107RNH Outer membrane receptor FepA AFA_09215 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) AFA_09220 ENOG4105C2W permease AFA_09225 ENOG4107Y70 Heat shock protein AFA_09265 ENOG41090MY MarR family Transcriptional regulator AFA_09270 ENOG4105E09 nadh pyrophosphatase AFA_09275 ENOG4105DSJ YicC domain protein AFA_09280 ENOG4107RFY SbcCD D subunit AFA_09290 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) AFA_09295 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) AFA_09300 ENOG4105CSA Coproporphyrinogen iii oxidase AFA_09305 ENOG4105C5F glutamine synthetase AFA_09310 ENOG4107YB6 acetyltransferase, (GNAT) family AFA_09330 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) AFA_09335 ENOG4107Z6A sulfate abc transporter permease AFA_09340 ENOG4107QKW extracellular solute-binding protein family 1 AFA_09345 ENOG4105DP0 ferredoxin-NADP reductase AFA_09350 ENOG4105KME endoribonuclease L-psp AFA_09355 ENOG4105CB5 ATP-dependent DNA helicase recG AFA_09370 ENOG4105CP9 extracellular ligand-binding receptor AFA_09375 ENOG4108IJ9 (ABC) transporter AFA_09390 ENOG4105BZ7 extracellular solute-binding protein family 1 AFA_09395 ENOG4105II7 pyrroline-5-carboxylate reductase AFA_09400 ENOG4105CP9 extracellular ligand-binding receptor AFA_09405 ENOG4105C32 Amino acid ABC transporter (Permease) AFA_09410 ENOG4105CF8 branched-chain amino acid ABC transporter, permease AFA_09415 ENOG4105C0Z ABC transporter AFA_09420 ENOG4108IV0 ABC, transporter AFA_09430 ENOG4108K3A Glutathione S-transferase AFA_09440 ENOG4105C5I Dehydrogenase AFA_09445 ENOG4105CHR reductase AFA_09450 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase AFA_09455 ENOG4105C9Q fumarate hydratase class II AFA_09460 ENOG4105D8V Glucose sorbosone dehydrogenase AFA_09465 ENOG4108I0C methyltransferase AFA_09470 ENOG4107YZX Universal stress protein AFA_09475 ENOG4105W2Z cytochrome C, class I AFA_09480 ENOG4105DJ2 Major Facilitator Superfamily AFA_09490 ENOG4105EJC lysr family transcriptional regulator AFA_09505 ENOG4108V0E nucleoside 2-deoxyribosyltransferase YtoQ AFA_09510 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) AFA_09520 ENOG4105E3B Multicopper oxidase AFA_09525 ENOG4108EF9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR AFA_09535 ENOG4105CSR polyphosphate kinase 2 AFA_09670 ENOG4105D9P serine threonine protein kinase AFA_09705 ENOG4105T95 Thiol disulfide interChange protein AFA_09745 ENOG4105C0D helicase AFA_09765 ENOG4108YGG dna repair protein AFA_09820 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) AFA_09835 ENOG4108YUH AFA_09885 ENOG4107U53 septum site-determining protein minD AFA_09945 ENOG4105CS6 Rhs element vgr protein AFA_09950 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit AFA_09990 ENOG4105CYX Short-chain dehydrogenase reductase Sdr AFA_09995 ENOG4105EWC Purine nucleoside phosphorylase AFA_10030 ENOG4105CPW cytochrome b561 AFA_10040 ENOG4108YYC ycei family AFA_10045 ENOG4105K89 arsenate reductase AFA_10050 ENOG4105CYM Glutathione S-transferase AFA_10060 ENOG4108YYH Nadph-dependent fmn reductase AFA_10070 ENOG4105F8V Hydrolase, tatD family AFA_10075 ENOG4107QRG dna polymerase iii AFA_10085 ENOG4105HHA aminodeoxychorismate lyase AFA_10090 ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) AFA_10095 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase AFA_10105 ENOG4105C1G acyl-Coa dehydrogenase AFA_10110 ENOG4105VDB UPF0125 protein AFA_10115 ENOG4108Z1B Cyclase dehydrase AFA_10120 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) AFA_10125 ENOG4105CEP NADH dehydrogenase AFA_10135 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) AFA_10140 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) AFA_10155 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) AFA_10160 ENOG4105D0V Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) AFA_10170 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) AFA_10175 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) AFA_10185 ENOG4105E1Z Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane AFA_10190 ENOG4105DZP Membrane-associated zinc metalloprotease AFA_10195 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) AFA_10200 ENOG4105KNE Phosphatidate cytidylyltransferase AFA_10205 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) AFA_10210 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) AFA_10215 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) AFA_10220 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) AFA_10225 ENOG4105CE9 30S ribosomal protein S2 AFA_10230 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) AFA_10235 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) AFA_10255 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase AFA_10260 ENOG4105E96 Colicin v production protein AFA_10270 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase AFA_10275 ENOG4107QN2 dihydrolipoyl dehydrogenase AFA_10280 ENOG4107QSN dihydrolipoamide acetyltransferase AFA_10285 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) AFA_10290 ENOG4105BZU Histidine kinase AFA_10300 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) AFA_10305 ENOG4105DGW oligopeptidase A AFA_10315 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) AFA_10325 ENOG4105YVS arsR family transcriptional regulator AFA_10335 ENOG4108Z6Z Transcriptional regulator AFA_10340 ENOG4105CG6 trap dicarboxylate transporter dctm subunit AFA_10345 ENOG4105XDZ Tripartite ATP-independent periplasmic transporter AFA_10350 ENOG4105GQU Trap dicarboxylate transporter, dctp subunit AFA_10355 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) AFA_10360 ENOG4105CHR reductase AFA_10405 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) AFA_10410 ENOG4105ENJ RND efflux system, outer membrane lipoprotein AFA_10415 ENOG4105BZS acriflavin resistance protein AFA_10420 ENOG4105C1P efflux transporter, rnd family, mfp subunit AFA_10425 ENOG4105D5T phosphonate abc transporter AFA_10445 ENOG4105CHU acetyl-coa acetyltransferase AFA_10450 ENOG4105CHU acetyl-coa acetyltransferase AFA_10460 ENOG4105CR4 methylisocitrate lyase AFA_10465 ENOG4105EMY transcriptional regulator AFA_10470 ENOG4105CXN decarboxylase AFA_10490 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) AFA_10495 ENOG4105VFG Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) AFA_10500 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) AFA_10510 ENOG4108UMN azlc family AFA_10515 ENOG4105DR5 peptidase AFA_10520 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) AFA_10525 ENOG4107T6V glycerophosphoryl diester phosphodiesterase AFA_10530 ENOG4105D6S protein involved in catabolism of external DNA AFA_10535 ENOG4105FE9 pseudouridine synthase AFA_10540 ENOG4105RUM Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4- hydroxybenzoate (4HB) for the ubiquinone pathway (By similarity) AFA_10545 ENOG4105DXI Major Facilitator superfamily AFA_10550 ENOG4105CV8 reductase AFA_10555 ENOG4108YZA Nitrogen regulatory protein pii AFA_10560 ENOG4105CUY Mechanosensitive ion channel AFA_10565 ENOG4105CH7 arginosuccinase AFA_10580 ENOG4105CJP fad dependent oxidoreductase AFA_10590 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) AFA_10595 ENOG4108K5P (LipO)protein AFA_10600 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) AFA_10605 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) AFA_10610 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) AFA_10615 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) AFA_10620 ENOG4105C7N Xanthine uracil vitamin C permease AFA_10625 ENOG41080RH Thioredoxin AFA_10645 ENOG4105C5H ABC transporter AFA_10650 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A AFA_10655 ENOG4108Z6B deaminase AFA_10660 ENOG4105DA5 (ABC) transporter AFA_10665 ENOG4105E3A (ABC) transporter AFA_10675 ENOG4105CG6 trap dicarboxylate transporter dctm subunit AFA_10680 ENOG4105XDZ Tripartite ATP-independent periplasmic transporter AFA_10685 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit AFA_10690 ENOG4105CJP fad dependent oxidoreductase AFA_10700 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) AFA_10720 ENOG4108FUF Transcriptional regulator, IclR family AFA_10725 ENOG4108E94 phosphate acetyltransferase AFA_10730 ENOG4105P69 integral membrane protein AFA_10740 ENOG4108VPT UPF0234 protein AFA_10745 ENOG4105CEY Amp-dependent synthetase and ligase AFA_10750 ENOG4107Z6W Protein CrcB homolog AFA_10755 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) AFA_10760 ENOG41075H3 AraC family transcriptional regulator AFA_10765 ENOG4105DHU Bile acid AFA_10775 ENOG4107ZT5 Thiol disulfide interchange protein AFA_10780 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase AFA_10785 ENOG4105CG6 trap dicarboxylate transporter dctm subunit AFA_10795 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) AFA_10805 ENOG4107QJH Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) AFA_10810 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) AFA_10815 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) AFA_10820 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) AFA_10825 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) AFA_10835 ENOG4108ZXC Two component transcriptional regulator, luxr family AFA_10850 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase AFA_10855 ENOG4105CNG UPF0061 protein AFA_10865 ENOG4107S2Z UPF0761 membrane protein AFA_10875 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) AFA_10945 ENOG4108S3W Anti-feci sigma factor, fecr AFA_10950 ENOG4108SF5 RNA Polymerase AFA_10960 ENOG4105F0N pyrophosphate phospho-hydrolase AFA_10970 ENOG4105ECF c-methyltransferase AFA_10980 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) AFA_10985 ENOG4108ZCF integral membrane protein AFA_10990 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha AFA_10995 ENOG4105CMV Succinyl-CoA synthetase subunit beta AFA_11005 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) AFA_11010 ENOG4105DZ2 Transcriptional regulator AFA_11015 ENOG4108004 Modulates RecA activity (By similarity) AFA_11035 ENOG4105CSH Transporter AFA_11050 ENOG4105CEY Amp-dependent synthetase and ligase AFA_11055 ENOG4105E9F Enoyl-CoA hydratase AFA_11060 ENOG41062QD Membrane AFA_11065 ENOG4107QN1 sodium solute AFA_11070 ENOG4105C26 Dehydrogenase AFA_11075 ENOG4105CXT aspartate transcarbamylase AFA_11090 ENOG4105BZ4 penicillin-binding protein AFA_11095 ENOG4107S52 alpha-2-macroglobulin domain protein AFA_11105 ENOG4105EA8 2-Nitropropane dioxygenase AFA_11110 ENOG4105D4P Coproporphyrinogen iii oxidase AFA_11115 ENOG4105D65 subunit l AFA_11120 ENOG4108ZE9 Monovalent cation H antiporter subunit C AFA_11125 ENOG4107R4Z monovalent cation h antiporter subunit d AFA_11135 ENOG4105W4C monovalent cation H antiporter subunit F AFA_11150 ENOG4105DFH Transport of potassium into the cell (By similarity) AFA_11155 ENOG4105DHQ Histidine kinase AFA_11180 ENOG4108IJ6 ABC transporter AFA_11185 ENOG4105ECW sulfate abc transporter AFA_11190 ENOG4108I5D sulfate abc transporter AFA_11195 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein AFA_11210 ENOG4105VEQ Cold shock protein AFA_11230 ENOG4105K70 DNA-binding protein AFA_11235 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) AFA_11245 ENOG4106P6N cytochrome d1 heme region AFA_11250 ENOG4108UMR transcriptional regulator AsnC family AFA_11255 ENOG4108ZGY Transcriptional regulator (AsnC family) AFA_11260 ENOG4108UMR transcriptional regulator AsnC family AFA_11265 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) AFA_11275 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) AFA_11290 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family AFA_11295 ENOG4105C28 cystathionine AFA_11300 ENOG4105C2N RNA methyltransferase TrmH family group 3 AFA_11305 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) AFA_11335 ENOG4105Q26 Siderophore-interacting protein AFA_11355 ENOG4105EHH Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue (By similarity) AFA_11365 ENOG4105DUM transcriptional regulator, lysR family AFA_11370 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) AFA_11380 ENOG4108KAZ Involved in phosphonate degradation (By similarity) AFA_11385 ENOG4105C4Y ABC transporter AFA_11395 ENOG4108Z7F N-acetyltransferase AFA_11405 ENOG4105CDZ Carboxymethylenebutenolidase (EC 3.1.1.45) AFA_11410 ENOG4105VRT cytoplasmic protein AFA_11415 ENOG4105CYM Glutathione S-transferase AFA_11425 ENOG4105EUB pirin domain protein AFA_11435 ENOG4107QPI nitrilase cyanide hydratase and apolipoprotein n-acyltransferase AFA_11440 ENOG4105F27 Major Facilitator AFA_11445 ENOG4105DJ2 Major Facilitator Superfamily AFA_11450 ENOG4105R1U AraC Family Transcriptional Regulator AFA_11455 ENOG4105DKK Benzoate AFA_11465 ENOG4105E7W lamb ycsf family protein AFA_11480 ENOG4105C7W Xanthine dehydrogenase AFA_11490 ENOG4107QUY Guanine deaminase AFA_11500 ENOG4105XJC Two component transcriptional regulator (Winged helix family AFA_11510 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AFA_11515 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) AFA_11520 ENOG4105VCC 30S ribosomal protein S21 AFA_11525 ENOG4105DYA Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity) AFA_11530 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis AFA_11535 ENOG4105C49 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity) AFA_11540 ENOG4105EPW hflc protein AFA_11545 ENOG4107QJR hflk protein AFA_11550 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) AFA_11555 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) AFA_11560 ENOG4105CIH Imidazole acetol-phosphate transaminase AFA_11565 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) AFA_11570 ENOG4105CNE Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) AFA_11575 ENOG4105N21 Membrane AFA_11580 ENOG4105CUT histidyl-tRNA synthetase AFA_11585 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) AFA_11595 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs AFA_11600 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) AFA_11610 ENOG4108HWB Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) AFA_11615 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) AFA_11620 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) AFA_11625 ENOG4105K5M 30s ribosomal protein S16 AFA_11630 ENOG41082K8 Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity) AFA_11635 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) AFA_11675 ENOG4105BZ7 extracellular solute-binding protein family 1 AFA_11680 ENOG4105MWK D-amino acid dehydrogenase, small subunit AFA_11690 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) AFA_11695 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) AFA_11700 ENOG4105K63 Thioredoxin AFA_11705 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) AFA_11710 ENOG4105D82 Glutamate dehydrogenase AFA_11725 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) AFA_11730 ENOG4105WPN DNA integration recombination invertion protein AFA_11735 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit AFA_11740 ENOG4105DS0 Transcriptional regulator, Crp Fnr family AFA_11755 ENOG4105C58 cytochrome c oxidase accessory protein ccog AFA_11775 ENOG4105EUH cytochrome C oxidase, cbb3-type, subunit i AFA_11785 ENOG4105C59 p-type ATPase AFA_11800 ENOG4105CSD Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) AFA_11815 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) AFA_11820 ENOG4107QPA Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides (By similarity) AFA_11825 ENOG4105KJV Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) AFA_11835 ENOG4108ZJI phenylacetic acid degradation protein AFA_11840 ENOG4108UKI Enoyl-CoA hydratase AFA_11845 ENOG4105C26 Dehydrogenase AFA_11850 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) AFA_11855 ENOG4108ZA2 phenylacetate-CoA oxygenase PaaJ subunit AFA_11860 ENOG4105D9S phenylacetate-CoA oxygenase PaaI subunit AFA_11865 ENOG4105N76 Phenylacetate-CoA oxygenase, subunit AFA_11870 ENOG4105CRS phenylacetate-CoA oxygenase PaaG subunit AFA_11875 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) AFA_11880 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 AFA_11885 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) AFA_11895 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) AFA_11910 ENOG4105D3R alkyl hydroperoxide reductase AFA_11915 ENOG4105CSU acyl-Coa dehydrogenase AFA_11920 ENOG4105C10 Electron transfer flavoprotein AFA_11925 ENOG4105BZJ Electron transfer flavoprotein AFA_11930 ENOG4105DGU Histone deacetylase AFA_11935 ENOG4105CVE Lytic murein transglycosylase AFA_11940 ENOG4105C6T cysteine synthase AFA_11945 ENOG4105C0B DNA polymerase III (alpha subunit) AFA_11950 ENOG4105CUI Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity) AFA_11955 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) AFA_11960 ENOG4105CFV Tetratricopeptide repeat protein AFA_11975 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) AFA_11980 ENOG4105CAT Cytidine monophosphate kinase AFA_11985 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase AFA_11990 ENOG4105EVN Prephenate dehydrogenase AFA_11995 ENOG4105CQC Prephenate dehydratase AFA_12000 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) AFA_12005 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) AFA_12010 ENOG4105UYK outer membrane protein a AFA_12015 ENOG4108HWB Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) AFA_12020 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) AFA_12025 ENOG4105DUM transcriptional regulator, lysR family AFA_12035 ENOG4108Z4U Ferredoxin AFA_12045 ENOG4105D05 Receptor AFA_12070 ENOG4105F1N DNA alkylation repair AFA_12075 ENOG41082F9 transcriptional regulator AFA_12080 ENOG4105CHM Aminotransferase AFA_12085 ENOG4108IG5 Transcriptional regulator AFA_12120 ENOG4108K3A Glutathione S-transferase AFA_12200 ENOG4105CMA conjugation trbi family protein AFA_12245 ENOG4105D7A ATP-binding protein AFA_12300 ENOG4105CVR type I restriction-modification system AFA_12340 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) AFA_12355 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) AFA_12360 ENOG4107RRE RNA-directed DNA polymerase AFA_12365 ENOG4105VEQ Cold shock protein AFA_12375 ENOG4108MXD gtp-binding protein AFA_12385 ENOG4108IYT Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) AFA_12400 ENOG410829K Lysine exporter protein (Lyse ygga) AFA_12425 ENOG4107QN1 sodium solute AFA_12435 ENOG4105BZU Histidine kinase AFA_12440 ENOG4107RIQ Sulfate adenylate transferase AFA_12445 ENOG4108SUT Major Facilitator Superfamily AFA_12455 ENOG410642W LysR family Transcriptional regulator AFA_12460 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) AFA_12475 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor AFA_12490 ENOG4105EXG Transcriptional regulator AFA_12495 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) AFA_12500 ENOG4107T1C Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity) AFA_12515 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) AFA_12520 ENOG4105CGZ zinc metallopeptidase AFA_12530 ENOG4108YZA Nitrogen regulatory protein pii AFA_12535 ENOG4105BZU Histidine kinase AFA_12540 ENOG4105T86 cytochrome C AFA_12545 ENOG4107QTF adenylosuccinate lyase AFA_12550 ENOG4108U78 Glutathione S-transferase AFA_12565 ENOG4105HF0 Membrane AFA_12570 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) AFA_12575 ENOG4105CQB FAD linked oxidase domain protein AFA_12580 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) AFA_12585 ENOG4105VCD cytoplasmic protein AFA_12590 ENOG4105D22 carbon starvation protein AFA_12625 ENOG4105EV8 ectoine hydroxylase AFA_12630 ENOG4108Z6K Catalyzes the circularization of gamma-N-acetyl- alpha,gamma-diaminobutyric acid (ADABA) to ectoine (1,4,5,6- tetrahydro-2-methyl-4-pyrimidine carboxylic acid), which is an excellent osmoprotectant (By similarity) AFA_12635 ENOG4108JPW Aminotransferase AFA_12645 ENOG41090MY MarR family Transcriptional regulator AFA_12660 ENOG4105D1U peptidase U62 modulator of DNA gyrase AFA_12665 ENOG4105VFQ Histone family protein nucleoid-structuring protein H-NS AFA_12675 ENOG4105CD8 aminopeptidase N AFA_12680 ENOG4105CZI D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 AFA_12685 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein AFA_12695 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) AFA_12705 ENOG4105D7A ATP-binding protein AFA_12710 ENOG4105CDY transcriptional regulatory protein AFA_12715 ENOG4105C12 Phosphoribosylglycinamide synthetase AFA_12720 ENOG4105DBS Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity) AFA_12725 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) AFA_12730 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) AFA_12735 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) AFA_12740 ENOG4108Z03 MAF-like protein AFA_12745 ENOG4108KHN disulfide isomerase, thiol-disulfide oxidase AFA_12760 ENOG4108ZJT translation initiation factor, Sui1 AFA_12770 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase AFA_12775 ENOG4108RXX maleylacetoacetate isomerase AFA_12780 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) AFA_12785 ENOG4108YZY peptidylprolyl cis-trans isomerase AFA_12790 ENOG4105W5Q DNA repair protein (RadC AFA_12795 ENOG4105NRA 50s ribosomal protein l31 type b AFA_12805 ENOG4107QI1 Mate efflux family protein AFA_12810 ENOG4108IJ7 Glycine betaine AFA_12815 ENOG4108HQS Glycine betaine AFA_12825 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase AFA_12830 ENOG4105C2C drug resistance transporter, Bcr CflA AFA_12835 ENOG4105KDC 50s ribosomal protein l28 AFA_12840 ENOG4105W0E 50S ribosomal protein L33 AFA_12845 ENOG4105C8T Leucyl-tRNA synthetase AFA_12855 ENOG4105DJF DNA polymerase III, delta' subunit AFA_12860 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) AFA_12870 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) AFA_12880 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) AFA_12890 ENOG4105XX3 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) AFA_12895 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) AFA_12925 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) AFA_12950 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase AFA_12955 ENOG4108594 Permease of the drug metabolite transporter AFA_12960 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) AFA_12970 ENOG4105K4H Nlp p60 protein AFA_12980 ENOG4107R11 Transcriptional regulator AFA_12985 ENOG4105C26 Dehydrogenase AFA_12990 ENOG4105SKE transcriptional Regulator LysR family AFA_12995 ENOG4105E0K tonB-dependent siderophore receptor AFA_13005 ENOG4105EHG Permease protein AFA_13015 ENOG4105CPU Monooxygenase AFA_13030 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) AFA_13040 ENOG4108XRP Membrane AFA_13045 ENOG4105D7W serine acetyltransferase AFA_13060 ENOG41071DT Involved in DNA repair and RecF pathway recombination (By similarity) AFA_13065 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) AFA_13070 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) AFA_13075 ENOG4105C3F Signal peptidase i AFA_13080 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) AFA_13085 ENOG4105C0H protease AFA_13100 ENOG4105EMN RNA polymerase sigma factor AFA_13110 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) AFA_13120 ENOG4105CHR reductase AFA_13125 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase AFA_13130 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) AFA_13135 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) AFA_13140 ENOG4105VGS 50s ribosomal protein l32 AFA_13145 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein AFA_13150 ENOG4108UHJ MAF-like protein AFA_13155 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) AFA_13160 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase AFA_13165 ENOG4105DQ2 Is probably involved in the electron transfer between its heme and the molybdenum cofactor of the reductase catalytic subunit YedY (By similarity) AFA_13170 ENOG4105CCD The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity) AFA_13175 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) AFA_13180 ENOG4105EI2 Pseudouridine synthase AFA_13185 ENOG4105C03 ribonuclease AFA_13190 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) AFA_13195 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) AFA_13200 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) AFA_13205 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) AFA_13215 ENOG4107RH7 Nicotinate phosphoribosyltransferase AFA_13220 ENOG4108Z4U Ferredoxin AFA_13230 ENOG4108R3D Electron transport complex AFA_13235 ENOG4105CSM endonuclease III AFA_13245 ENOG4105EIF outer membrane protein W AFA_13250 ENOG4108IV0 ABC, transporter AFA_13255 ENOG4105C0Z ABC transporter AFA_13270 ENOG4105E0X reductase AFA_13275 ENOG4107835 probably involved in intracellular septation (By similarity) AFA_13285 ENOG4107TF3 peptidylprolyl cis-trans isomerase AFA_13290 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) AFA_13300 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) AFA_13310 ENOG4108UN4 phage SPO1 DNA polymerase-related protein AFA_13315 ENOG41072GX Peptidase M22 Glycoprotease AFA_13320 ENOG4105DPZ Two component transcriptional regulator (Winged helix family AFA_13325 ENOG4105E0F Histidine kinase AFA_13335 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) AFA_13340 ENOG4108JA2 transcriptioN-repair coupling factor AFA_13350 ENOG4105EAC phosphoserine phosphatase AFA_13355 ENOG4107QWG 2-Nitropropane dioxygenase AFA_13365 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) AFA_13370 ENOG4105C8S subunit m AFA_13380 ENOG4105M5H NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) AFA_13385 ENOG4105DF2 NADH dehydrogenase subunit j AFA_13390 ENOG4105P3U NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) AFA_13395 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) AFA_13400 ENOG4108IEH NADH dehydrogenase subunit g AFA_13415 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) AFA_13420 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain AFA_13425 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) AFA_13430 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain AFA_13435 ENOG4108Z9W Outer membrane porin AFA_13445 ENOG4107EJC Preprotein translocase subunit SecG AFA_13450 ENOG4105CP7 Triose-phosphate isomerase AFA_13455 ENOG4105CB2 alcohol dehydrogenase AFA_13480 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) AFA_13485 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase AFA_13490 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase AFA_13495 ENOG4108ZP8 Acetolactate synthase small subunit AFA_13500 ENOG4105C7K acetolactate synthase AFA_13510 ENOG4105D1Q UPF0246 protein AFA_13525 ENOG4106FGB Beta-lactamase AFA_13540 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) AFA_13545 ENOG4105D1H recombination factor protein RarA AFA_13550 ENOG4107Y7W Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity) AFA_13555 ENOG4105CNU cell division protein FtsK AFA_13560 ENOG4105C3M thioredoxin reductase AFA_13570 ENOG4105WAP TPR repeat-containing protein AFA_13600 ENOG4105EBR Carboxylesterase AFA_13605 ENOG4108KC1 acyl-Coa dehydrogenase AFA_13625 ENOG4106RE7 Cytochrome AFA_13630 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) AFA_13650 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family AFA_13755 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) AFA_13760 ENOG4105CFG Acts as a chaperone (By similarity) AFA_13765 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ AFA_13770 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) AFA_13775 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) AFA_13780 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) AFA_13785 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) AFA_13790 ENOG41090R7 Ferric uptake AFA_13795 ENOG4105YRI Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) AFA_13800 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) AFA_13810 ENOG4105D4A Cell wall formation (By similarity) AFA_13830 ENOG4105BZU Histidine kinase AFA_13840 ENOG4105CNM Receptor AFA_13845 ENOG4105C2C drug resistance transporter, Bcr CflA AFA_13860 ENOG4105NIV Esterase AFA_13865 ENOG4105C26 Dehydrogenase AFA_13870 ENOG4105C26 Dehydrogenase AFA_13875 ENOG4105EW9 transcriptional regulator AsnC family AFA_13885 ENOG4105CIF Ornithine Cyclodeaminase AFA_13890 ENOG4105CSH Transporter AFA_13895 ENOG4105C1J atp-dependent rna helicase AFA_13900 ENOG4105VUH addiction module killer protein AFA_13905 ENOG4105YES addiction module antidote protein AFA_13910 ENOG4108W5M transcriptional regulator AFA_13915 ENOG4105FUY alpha subunit AFA_13935 ENOG4108DNI pyridine nucleotide-disulfide oxidoreductase AFA_13945 ENOG4107UB2 Alpha beta hydrolase fold AFA_13955 ENOG4105DIV Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD( ) and coenzyme A. Is the final enzyme in the meta- cleavage pathway for the degradation of aromatic compounds (By similarity) AFA_13960 ENOG4105DF3 Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta-cleavage pathway for the degradation of aromatic compounds (By similarity) AFA_13965 ENOG4108SC4 )-transporter AFA_13980 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) AFA_13985 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family AFA_13990 ENOG4105DXI Major Facilitator superfamily AFA_14015 ENOG4105CHU acetyl-coa acetyltransferase AFA_14020 ENOG4105CHR reductase AFA_14030 ENOG4105CMI transporter AFA_14035 ENOG4105CJ1 ABC, transporter AFA_14040 ENOG4105D0S secretion protein (HlyD AFA_14045 ENOG4105ENJ RND efflux system, outer membrane lipoprotein AFA_14050 ENOG4105D1N poly(r)-hydroxyalkanoic acid synthase, class AFA_14060 ENOG4105EX9 Membrane AFA_14065 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) AFA_14070 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) AFA_14085 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) AFA_14100 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain AFA_14115 ENOG4108Z4X TRANSCRIPTIONal AFA_14125 ENOG4105BZS acriflavin resistance protein AFA_14145 ENOG4107TSX ABC branched chain amino acid family transporter periplasmic ligand binding protein AFA_14150 ENOG4105IW1 AmiS UreI transporter AFA_14175 ENOG4105EUH cytochrome C oxidase, cbb3-type, subunit i AFA_14180 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family AFA_14190 ENOG4105EVZ LysR family transcriptional regulator AFA_14195 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) AFA_14200 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) AFA_14215 ENOG4105HSS phospholipase C AFA_14235 ENOG4105EUR Domain-Containing protein AFA_14235 ENOG4105EUR Domain-Containing protein AFA_14235 ENOG4105EUR Domain-Containing protein AFA_14240 ENOG4105BZU Histidine kinase AFA_14245 ENOG4108C33 Resolvase AFA_14250 ENOG4105D7Q type ii secretion system AFA_14255 ENOG4107QHF type ii secretion system protein e AFA_14260 ENOG4105GVR general secretion pathway protein D AFA_14285 ENOG4108WWZ General secretion pathway protein J AFA_14300 ENOG4108VAU general secretion pathway protein G AFA_14310 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) AFA_14325 ENOG4108IJ0 Aspartate ammonia-lyase AFA_14330 ENOG41082F9 transcriptional regulator AFA_14340 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) AFA_14345 ENOG4108R4Z Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity) AFA_14350 ENOG4105DWA May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate AFA_14365 ENOG41069M3 Transcriptional regulator AFA_14385 ENOG4105C1J atp-dependent rna helicase AFA_14405 ENOG4105DNZ Alpha Beta Hydrolase AFA_14410 ENOG4105ERG peptidase m48, ste24p AFA_14430 ENOG4105D0A hydroxylase AFA_14435 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) AFA_14440 ENOG4105VY0 Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters (By similarity) AFA_14450 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) AFA_14455 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) AFA_14465 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) AFA_14475 ENOG4105EKE dihydroorotase AFA_14485 ENOG4105CVP deoxyribo-dipyrimidine photolyase AFA_14530 ENOG4105KHC sulfurtransferase AFA_14535 ENOG41066VF YeeE YedE family protein AFA_14545 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) AFA_14580 ENOG4105D38 putrescine abc transporter AFA_14585 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) AFA_14590 ENOG4107QKW extracellular solute-binding protein family 1 AFA_14595 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase AFA_14610 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) AFA_14615 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) AFA_14620 ENOG4107YD3 Thioesterase AFA_14625 ENOG4105E02 MotA TolQ exbB proton channel AFA_14630 ENOG4105M8F Biopolymer transport protein exbD tolR AFA_14640 ENOG4107R6Y Involved in the TonB-independent uptake of proteins (By similarity) AFA_14645 ENOG4105KCK Peptidoglycan-associated lipoprotein AFA_14670 ENOG4107QI1 Mate efflux family protein AFA_14685 ENOG4105UIB (ABC) transporter AFA_14690 ENOG4105C2J ABC transporter AFA_14705 ENOG4108NIW Leucine export protein LeuE AFA_14710 ENOG4105CYC Transferase AFA_14715 ENOG4105CMU LysR family (Transcriptional regulator AFA_14725 ENOG4108JU3 Alkyl hydroperoxide reductase AFA_14740 ENOG4105T38 integral membrane protein AFA_14750 ENOG4105C11 sulfate adenylyltransferase), subunit 2 AFA_14755 ENOG4105C3T may be the GTPase, regulating ATP sulfurylase activity (By similarity) AFA_14765 ENOG4105C26 Dehydrogenase AFA_14770 ENOG4105CJP fad dependent oxidoreductase AFA_14775 ENOG4105E32 cytoplasmic protein AFA_14780 ENOG4105ETT transcriptional Regulator, LysR family AFA_14785 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) AFA_14800 ENOG4105CC0 LysR family Transcriptional regulator AFA_14805 ENOG4105C2I pirin domain protein AFA_14810 ENOG4105BZU Histidine kinase AFA_14825 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) AFA_14830 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) AFA_14835 ENOG41080IJ Diacylglycerol kinase AFA_14840 ENOG4105SKN orotidine 5''-phosphate decarboxylase AFA_14855 ENOG4107HP6 Transcriptional regulator AFA_14865 ENOG4108ZAI phosphatidylglycerophosphatase a AFA_14870 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) AFA_14875 ENOG4107YIM Involved in the transcription termination process (By similarity) AFA_14880 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) AFA_14905 ENOG4106H78 methyltransferase AFA_14910 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) AFA_14915 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding AFA_14945 ENOG4108T7K Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Increasing levels of c-di-GMP lead to decreased motility (By similarity) AFA_14960 ENOG4108UAU isochorismatase AFA_14975 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding AFA_14980 ENOG4108XHQ (2Fe-2S)-binding domain protein AFA_14985 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding AFA_14995 ENOG4108IV0 ABC, transporter AFA_15000 ENOG4105C0Z ABC transporter AFA_15005 ENOG4105CF8 branched-chain amino acid ABC transporter, permease AFA_15010 ENOG41083Z3 extracellular ligand-binding receptor AFA_15020 ENOG4105BZU Histidine kinase AFA_15045 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) AFA_15050 ENOG4105FDP GntR family transcriptional regulator AFA_15060 ENOG4107RZC phospholipase d AFA_15070 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) AFA_15075 ENOG4107P0T Selenium-dependent molybdenum hydroxylase system protein, YqeB family AFA_15080 ENOG4105CG6 trap dicarboxylate transporter dctm subunit AFA_15105 ENOG4105CH5 extracellular solute-binding protein, family 7 AFA_15130 ENOG4108UAU isochorismatase AFA_15155 ENOG4105E0A ABC, transporter AFA_15160 ENOG4105EHG Permease protein AFA_15170 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) AFA_15175 ENOG4105CRW Short chain fatty acid transporter AFA_15190 ENOG4108JDX DNA polymerase iii, epsilon subunit AFA_15195 ENOG4105BZS acriflavin resistance protein AFA_15200 ENOG4105C1P efflux transporter, rnd family, mfp subunit AFA_15205 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) AFA_15210 ENOG4105D1A Methyltransferase AFA_15215 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) AFA_15220 ENOG4105E9H Lytic Murein transglycosylase AFA_15225 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH AFA_15240 ENOG4105CK2 sodium dicarboxylate symporter AFA_15250 ENOG4105C72 UPF0176 protein AFA_15270 ENOG4108UIN ybak prolyl-trna synthetase associated region AFA_15275 ENOG4108T2C cysteine dioxygenase type I AFA_15285 ENOG4105CD5 CoA-binding domain protein AFA_15295 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family AFA_15305 ENOG4105E9F Enoyl-CoA hydratase AFA_15320 ENOG4105CIS alcohol dehydrogenase AFA_15325 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase AFA_15330 ENOG4105JQN Transcriptional regulator AFA_15345 ENOG4105HSS phospholipase C AFA_15350 ENOG4105DUM transcriptional regulator, lysR family AFA_15355 ENOG4108KAZ Involved in phosphonate degradation (By similarity) AFA_15360 ENOG4105C0A alcohol dehydrogenase AFA_15420 ENOG4105K89 arsenate reductase AFA_15425 ENOG4105CAU Arsenical resistance protein, ArsH AFA_15430 ENOG4105XJC Two component transcriptional regulator (Winged helix family AFA_15435 ENOG4105DHQ Histidine kinase AFA_15450 ENOG4105C28 cystathionine AFA_15455 ENOG4105C0R drug resistance transporter emrb qaca subfamily AFA_15465 ENOG4105VDT -acetyltransferase AFA_15470 ENOG4105ECQ AraC Family Transcriptional Regulator AFA_15480 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) AFA_15485 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) AFA_15490 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) AFA_15495 ENOG4108V1U phospholipid-binding protein AFA_15500 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) AFA_15505 ENOG4105DR5 peptidase AFA_15510 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) AFA_15525 ENOG4108YX9 iron--sulfur cluster insertion protein erpA AFA_15535 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase AFA_15540 ENOG4108UJD 30S ribosomal protein S9 AFA_15545 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) AFA_15550 ENOG4105CH5 extracellular solute-binding protein, family 7 AFA_15555 ENOG4105CMS peptidase U62, modulator of DNA gyrase AFA_15560 ENOG4105N42 UPF0307 protein AFA_15575 ENOG4105CD5 CoA-binding domain protein AFA_15580 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic AFA_15590 ENOG4108ZXC Two component transcriptional regulator, luxr family AFA_15595 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) AFA_15600 ENOG4108VWS Yaeq family AFA_15610 ENOG4105J0Q Transcriptional regulator AFA_15625 ENOG4108VIA integral membrane protein AFA_15630 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) AFA_15635 ENOG4108XTF Outer Membrane Lipoprotein AFA_15650 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) AFA_15655 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase AFA_15660 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein AFA_15665 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) AFA_15670 ENOG4108IFH alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen AFA_15675 ENOG4105DFU Cell wall formation (By similarity) AFA_15680 ENOG4105IPS esterase AFA_15695 ENOG4105E2X shikimate dehydrogenase AFA_15700 ENOG4108VKV Monofunctional biosynthetic peptidoglycan transglycosylase AFA_15710 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) AFA_15715 ENOG4108Z20 Acyl-transferase AFA_15720 ENOG4107Y66 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) AFA_15725 ENOG4108UJU UPF0301 protein AFA_15730 ENOG4105VCQ rubredoxin AFA_15740 ENOG4107U6I Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) AFA_15745 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase AFA_15760 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) AFA_15770 ENOG4105VDW Csbd family AFA_15775 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) AFA_15780 ENOG4105K46 50S ribosomal protein l27 AFA_15785 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control AFA_15790 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) AFA_15815 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) AFA_15820 ENOG4105CDV Ompa motb domain protein AFA_15830 ENOG4105CDA abc transporter atp-binding protein AFA_15835 ENOG4105DRP amino acid AbC transporter AFA_15840 ENOG4105EZ7 amino acid ABC transporter AFA_15850 ENOG4105CAK Cell division ATP-binding protein ftsE AFA_15855 ENOG4105CRP Part of the ABC transporter FtsEX involved in AFA_15860 ENOG4105CEN a g-specific adenine glycosylase AFA_15865 ENOG4105CNI cell division protein FtsW AFA_15870 ENOG4105CJN penicillin-binding protein AFA_15880 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) AFA_15885 ENOG4105DFF Rod shape-determining protein mreb AFA_15890 ENOG41080G2 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) AFA_15895 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) AFA_15900 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) AFA_15910 ENOG4105EJC lysr family transcriptional regulator AFA_15915 ENOG4105MGM doxx family AFA_15920 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b AFA_15930 ENOG4105MPD Cytochrome AFA_15940 ENOG41067TZ transcriptional regulator, MarR family AFA_15945 ENOG4105CSU acyl-Coa dehydrogenase AFA_15955 ENOG4105CD5 CoA-binding domain protein AFA_15960 ENOG4108D7R p-hydroxycinnamoyl CoA hydratase lyase AFA_15965 ENOG4105DSQ Nitric oxide reductase AFA_15995 ENOG41060BG Tetr family transcriptional regulator AFA_16010 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase AFA_16035 ENOG4105ECP epimerase AFA_16040 ENOG4105D6U Sodium Glutamate Symporter AFA_16045 ENOG4105EAH synthase AFA_16055 ENOG4105M6F mutator MutT protein AFA_16060 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) AFA_16065 ENOG4105ENJ RND efflux system, outer membrane lipoprotein AFA_16085 ENOG4105DHA Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity (By similarity) AFA_16090 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) AFA_16100 ENOG4105WH1 Two component transcriptional regulator luxr family AFA_16105 ENOG4107R03 Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) AFA_16110 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) AFA_16120 ENOG4105C0R drug resistance transporter emrb qaca subfamily AFA_16145 ENOG4105C3R Methionine synthase AFA_16150 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) AFA_16155 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) AFA_16160 ENOG4105CNM Receptor AFA_16170 ENOG4108SF5 RNA Polymerase AFA_16180 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) AFA_16185 ENOG4105DWF phosphomethylpyrimidine kinase AFA_16190 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) AFA_16195 ENOG4108KE4 O-methyltransferase AFA_16200 ENOG4105DFG type I secretion outer membrane protein AFA_16205 ENOG4107Z67 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) AFA_16215 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) AFA_16230 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) AFA_16235 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AFA_16240 ENOG4105BZU Histidine kinase AFA_16250 ENOG4105P4J Allophanate hydrolase, subunit 1 AFA_16260 ENOG4105C7B Threonine dehydratase AFA_16265 ENOG4105W39 Membrane AFA_16300 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) AFA_16305 ENOG4108JJ8 (ABC) transporter AFA_16310 ENOG4108JJ9 ABC, transporter AFA_16320 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii AFA_16325 ENOG4105C4M (Ubiquinol oxidase) subunit I AFA_16335 ENOG4105C2X Arabinose 5-phosphate isomerase AFA_16340 ENOG4108Z4R 3-deoxy-d-manno-octulosonate 8-phosphate phosphatase AFA_16355 ENOG4108IUZ ABC transporter AFA_16360 ENOG41080QH sigma 54 modulation protein ribosomal protein S30EA AFA_16365 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN AFA_16370 ENOG4105D1C Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) AFA_16375 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) AFA_16385 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) AFA_16390 ENOG41082RQ UPF0102 protein AFA_16395 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) AFA_16410 ENOG4105CAS nag kinase AFA_16420 ENOG4105D06 uba thif-type nad fad binding protein AFA_16425 ENOG4105CN1 protease AFA_16430 ENOG41063SB peptidase AFA_16435 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) AFA_16440 ENOG4107YZP Rhodanese domain protein AFA_16450 ENOG4105IX2 One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity) AFA_16455 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase AFA_16465 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) AFA_16470 ENOG4105MJ2 Competence protein AFA_16475 ENOG4106T9E Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) AFA_16480 ENOG410908U Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) AFA_16485 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family AFA_16500 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B AFA_16510 ENOG4108Z0R Transferase AFA_16515 ENOG4105CMR udp-glucose 4-epimerase AFA_16530 ENOG4105CNV Aldolase AFA_16535 ENOG4108IY8 ABC, transporter AFA_16550 ENOG4105CKK Glycosyl transferase, family 2 AFA_16555 ENOG4107STW synthase AFA_16585 ENOG4105C1B dTDP-glucose 4-6-dehydratase AFA_16590 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) AFA_16595 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase AFA_16605 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) AFA_16610 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) AFA_16615 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) AFA_16620 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) AFA_16625 ENOG4107S15 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) AFA_16630 ENOG4107Z6K F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) AFA_16635 ENOG4105KY6 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) AFA_16640 ENOG4107RAZ it plays a direct role in the translocation of protons across the membrane (By similarity) AFA_16650 ENOG4105E39 Enoyl-CoA hydratase AFA_16665 ENOG4105CB3 Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity) AFA_16670 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase AFA_16680 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) AFA_16690 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) AFA_16700 ENOG4106TD9 Diguanylate cyclase AFA_16715 ENOG4105CNM Receptor AFA_16735 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) AFA_16745 ENOG4108KK1 membrane protein AbrB duplication AFA_16765 ENOG4105GR3 Histidine kinase AFA_16780 ENOG4105CSH Transporter AFA_16785 ENOG4105ES4 Nitrilase AFA_16805 ENOG4105E2Y ABC, transporter AFA_16830 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) AFA_16835 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) AFA_16840 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein AFA_16845 ENOG4108MG3 formate dehydrogenase AFA_16850 ENOG4105F46 Necessary for formate dehydrogenase activity (By similarity) AFA_16855 ENOG4105C1Y Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis (By similarity) AFA_16860 ENOG4105EM7 Selenocysteine-specific translation elongation factor AFA_16875 ENOG4108S8N class II Aldolase AFA_16890 ENOG4107RNH Outer membrane receptor FepA AFA_16900 ENOG4105CNM Receptor AFA_16905 ENOG4105D4F Synthesizes selenophosphate from selenide and ATP (By similarity) AFA_16910 ENOG4105CR7 Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA (By similarity) AFA_16920 ENOG4105EQJ Nitrous-oxide reductase is part of a bacterial respiratory system which is activated under anaerobic conditions in the presence of nitrate or nitrous oxide (By similarity) AFA_16930 ENOG4105CIG ABC transporter AFA_16935 ENOG4108T0W nitrous oxide maturation protein NosY AFA_16950 ENOG4107QP8 phosphohexose isomerase AFA_16985 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) AFA_17010 ENOG4108IJ1 Dehydrogenase AFA_17025 ENOG4105ECX polysaccharide export AFA_17035 ENOG41090SZ ABC-2 type transporter AFA_17045 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) AFA_17055 ENOG4105C2W permease AFA_17060 ENOG4105T38 integral membrane protein AFA_17065 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family AFA_17070 ENOG4107Y9U Membrane AFA_17080 ENOG4105CHU acetyl-coa acetyltransferase AFA_17100 ENOG4105DHJ ABC, transporter AFA_17105 ENOG4105CY3 ABC transporter, permease AFA_17110 ENOG4107PE3 Mammalian cell entry related domain protein AFA_17125 ENOG4105DA5 (ABC) transporter AFA_17130 ENOG4105E3A (ABC) transporter AFA_17140 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) AFA_17145 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) AFA_17150 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) AFA_17155 ENOG4105ECC imidazole-glycerol-phosphate dehydratase AFA_17160 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) AFA_17165 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase AFA_17170 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) AFA_17175 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase AFA_17180 ENOG4105KPZ phosphoribosyl-atp pyrophosphatase AFA_17185 ENOG4107YU2 histidine triad (hIT) protein AFA_17190 ENOG4105WKS Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) AFA_17195 ENOG4105X8U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) AFA_17205 ENOG4105C0H protease AFA_17210 ENOG4107QNR UPF0135 protein AFA_17215 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) AFA_17220 ENOG4108R5F Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) AFA_17225 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) AFA_17230 ENOG4105EIX cytochrome c1 AFA_17235 ENOG4107MKT Stringent starvation protein a AFA_17240 ENOG4105KB2 stringent starvation protein b AFA_17245 ENOG4105ECW sulfate abc transporter AFA_17250 ENOG4108I5D sulfate abc transporter AFA_17255 ENOG4108J2H Sulfate ABC transporter periplasmic sulfate-binding protein AFA_17285 ENOG4105C5I Dehydrogenase AFA_17295 ENOG4105CG6 trap dicarboxylate transporter dctm subunit AFA_17305 ENOG4105CH5 extracellular solute-binding protein, family 7 AFA_17310 ENOG4105EXW epimerase dehydratase AFA_17315 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) AFA_17325 ENOG4105C01 Dihydroxy-acid dehydratase AFA_17330 ENOG4108WYP Transcriptional regulator AFA_17335 ENOG4105F7P transcriptional regulator AsnC family AFA_17340 ENOG4105HJ8 Catalyzes the oxidative cleavage of the L-tryptophan (L- Trp) pyrrole ring (By similarity) AFA_17360 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) AFA_17365 ENOG4105CV8 reductase AFA_17375 ENOG4107QM5 aconitate hydratase AFA_17380 ENOG4105BZU Histidine kinase AFA_17385 ENOG4105DHI Methyltransferase AFA_17415 ENOG4105F04 LysR family Transcriptional regulator AFA_17420 ENOG4105CHR reductase AFA_17425 ENOG4105CHJ isochorismatase hydrolase AFA_17430 ENOG4105EUB pirin domain protein AFA_17435 ENOG4105JQN Transcriptional regulator AFA_17440 ENOG4105VDW Csbd family AFA_17445 ENOG4105K3G Periplasmic Protein AFA_17455 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family AFA_17485 ENOG4108SF5 RNA Polymerase AFA_17495 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) AFA_17500 ENOG4108XM1 transcriptional regulator AsnC family AFA_17515 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) AFA_17530 ENOG4105CV4 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity) AFA_17535 ENOG4105BZ9 Cytochrome C oxidase, subunit I AFA_17545 ENOG4107QS1 Cytochrome C Oxidase, Subunit III AFA_17570 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) AFA_17575 ENOG4105EQD regulatoR AFA_17595 ENOG4107RNH Outer membrane receptor FepA AFA_17610 ENOG4107QPD alcohol dehydrogenase AFA_17615 ENOG4105DZQ phospholipase D Transphosphatidylase AFA_17620 ENOG4105X23 Endonuclease Exonuclease phosphatase AFA_17625 ENOG4105C9M aspartyl-trna synthetase AFA_17650 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family AFA_17660 ENOG4105CI2 imidazolone-5-propionate hydrolase AFA_17680 ENOG4105C84 Histidine ammonia-lyase AFA_17685 ENOG4105CGP Urocanate hydratase AFA_17710 ENOG4108Z6Z Transcriptional regulator AFA_17730 ENOG4105CYM Glutathione S-transferase AFA_17755 ENOG4105CGF Aromatic amino acid aminotransferase AFA_17760 ENOG4105M2Z protein tyrosine serine phosphatase AFA_17765 ENOG4105CY0 Metallo-Beta-Lactamase AFA_17785 ENOG4105CIF Ornithine Cyclodeaminase AFA_17830 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) AFA_17845 ENOG4105DRR Transcriptional regulator, GntR family AFA_17850 ENOG4105EJ2 Transcriptional regulator AFA_17855 ENOG4105C2C drug resistance transporter, Bcr CflA AFA_17870 ENOG4105CZM Major Facilitator AFA_17875 ENOG4108UUM single-stranded DNA-binding protein AFA_17880 ENOG4107RDB Major Facilitator AFA_17890 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein AFA_17895 ENOG4105D49 3-dehydroquinate synthase AFA_17900 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) AFA_17905 ENOG4108JQC penicillin-binding protein 1A AFA_17915 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) AFA_17920 ENOG4105BZU Histidine kinase AFA_17925 ENOG4105CRE cytochrome C AFA_17930 ENOG4105EBH Required during biogenesis of c-type cytochromes (cytochrome c6 and cytochrome f) at the step of heme attachment (By similarity) AFA_17940 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) AFA_17945 ENOG4105D52 delta-aminolevulinic acid dehydratase AFA_17950 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) AFA_17970 ENOG4105EQP Catalyzes the pyrimidine ring opening between N-3 and C- 4 by an unusual flavin hydroperoxide-catalyzed mechanism to yield ureidoacrylate peracid. It cleaves pyrmidine rings directly by adding oxygen atoms, making a toxic ureidoacrylate peracid product which can be spontaneously reduced to ureidoacrylate (By similarity) AFA_17975 ENOG4108ZT0 50S ribosomal protein l17 AFA_17980 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) AFA_17985 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) AFA_17990 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) AFA_17995 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits AFA_18010 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) AFA_18015 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) AFA_18020 ENOG4105VPB 50S ribosomal protein L30 AFA_18025 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) AFA_18030 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) AFA_18035 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) AFA_18040 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) AFA_18045 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) AFA_18050 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits AFA_18055 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) AFA_18060 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) AFA_18090 ENOG4108JJA ABC, transporter AFA_18100 ENOG4105DFG type I secretion outer membrane protein AFA_18105 ENOG4105EUR Domain-Containing protein AFA_18110 ENOG4105HSS phospholipase C AFA_18125 ENOG4105D5T phosphonate abc transporter AFA_18135 ENOG4105D4U had-superfamily hydrolase, subfamily iia AFA_18140 ENOG4106KNT transcriptional regulator AFA_18155 ENOG4107QPN acyl-Coa dehydrogenase AFA_18160 ENOG4105CHU acetyl-coa acetyltransferase AFA_18165 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase AFA_18170 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation AFA_18185 ENOG4105CEY Amp-dependent synthetase and ligase AFA_18190 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) AFA_18195 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) AFA_18200 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) AFA_18215 ENOG4105D7T ABC transporter AFA_18220 ENOG4105C1G acyl-Coa dehydrogenase AFA_18235 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal AFA_18240 ENOG41084PQ 50s ribosomal protein l29 AFA_18245 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) AFA_18250 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) AFA_18255 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) AFA_18260 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) AFA_18265 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity AFA_18270 ENOG41080KG One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) AFA_18275 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) AFA_18280 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) AFA_18285 ENOG4108IJ7 Glycine betaine AFA_18290 ENOG4108HQS Glycine betaine AFA_18295 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) AFA_18300 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) AFA_18305 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) AFA_18310 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) AFA_18315 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) AFA_18350 ENOG4107QR0 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) AFA_18355 ENOG4107QIH DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) AFA_18360 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) AFA_18365 ENOG4108VZM 50s ribosomal protein L10 AFA_18370 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) AFA_18375 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) AFA_18395 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) AFA_18415 ENOG4105FA0 parb-like partition protein AFA_18420 ENOG4107QJE Chromosome Partitioning Protein AFA_18430 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) AFA_18435 ENOG4105CHM Aminotransferase AFA_18440 ENOG4107S1Q Phosphatase AFA_18445 ENOG4105BZU Histidine kinase AFA_18450 ENOG4105DJ4 phosphatidylserine decarboxylase AFA_18460 ENOG4105C7B Threonine dehydratase AFA_18470 ENOG4105JAB phenazine biosynthesis protein, phzf family AFA_18505 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) AFA_18535 ENOG4105CP9 extracellular ligand-binding receptor AFA_18540 ENOG4105C32 Amino acid ABC transporter (Permease) AFA_18550 ENOG4105C0Z ABC transporter AFA_18555 ENOG4108IV0 ABC, transporter AFA_18570 ENOG4108UAU isochorismatase AFA_18595 ENOG4105CH6 catalase AFA_18600 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins AFA_18605 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) AFA_18610 ENOG4105X5M RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) AFA_18615 ENOG4105VG0 50S ribosomal protein l34