locus-tag	class	description
GWQ43_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
GWQ43_00010	COG0592	DNA-directed DNA polymerase activity
GWQ43_00020	COG1187	pseudouridine synthase activity
GWQ43_00035	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
GWQ43_00060	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
GWQ43_00065	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GWQ43_00085	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GWQ43_00105	COG2070	2-Nitropropane dioxygenase
GWQ43_00115	COG1960	acyl-CoA dehydrogenase activity
GWQ43_00125	COG1804	L-carnitine dehydratase bile acid-inducible protein F
GWQ43_00135	COG1804	L-carnitine dehydratase bile acid-inducible protein F
GWQ43_00145	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
GWQ43_00165	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
GWQ43_00170	COG0583	DNA-binding transcription factor activity
GWQ43_00180	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
GWQ43_00185	COG1802	Transcriptional regulator
GWQ43_00190	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
GWQ43_00195	COG2271	Major facilitator Superfamily
GWQ43_00205	COG0436	Aminotransferase
GWQ43_00215	COG0559	Belongs to the binding-protein-dependent transport system permease family
GWQ43_00230	COG0318	PFAM AMP-dependent synthetase and ligase
GWQ43_00240	COG0508	dehydrogenase complex catalyzes the overall conversion of
GWQ43_00240	COG0596	Alpha beta hydrolase
GWQ43_00245	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GWQ43_00260	COG3181	Tripartite tricarboxylate transporter family receptor
GWQ43_00270	COG0697	spore germination
GWQ43_00275	COG0583	DNA-binding transcription factor activity
GWQ43_00285	COG3842	ATPase activity
GWQ43_00295	COG0436	Aminotransferase
GWQ43_00305	COG0523	cobalamin synthesis protein
GWQ43_00360	COG1846	Transcriptional regulator
GWQ43_00380	COG0179	Fumarylacetoacetate (FAA) hydrolase
GWQ43_00385	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GWQ43_00390	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
GWQ43_00400	COG4638	Rieske (2fe-2S)
GWQ43_00455	COG1028	Short-chain dehydrogenase reductase Sdr
GWQ43_00505	COG1595	DNA-templated transcription, initiation
GWQ43_00510	COG4608	Belongs to the ABC transporter superfamily
GWQ43_00515	COG0444	Belongs to the ABC transporter superfamily
GWQ43_00520	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GWQ43_00535	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GWQ43_00540	COG1595	DNA-templated transcription, initiation
GWQ43_00545	COG3712	iron ion homeostasis
GWQ43_00550	COG4774	siderophore transport
GWQ43_00555	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
GWQ43_00560	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GWQ43_00575	COG1464	Belongs to the NlpA lipoprotein family
GWQ43_00580	COG1464	Belongs to the NlpA lipoprotein family
GWQ43_00585	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
GWQ43_00590	COG2011	ABC-type metal ion transport system permease component
GWQ43_00615	COG1464	Belongs to the NlpA lipoprotein family
GWQ43_00625	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
GWQ43_00645	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GWQ43_00650	COG0431	NADPH-dependent FMN reductase
GWQ43_00685	COG4149	molybdate abc transporter
GWQ43_00695	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
GWQ43_00700	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
GWQ43_00710	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
GWQ43_00730	COG0028	Belongs to the TPP enzyme family
GWQ43_00735	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
GWQ43_00765	COG2922	Belongs to the Smg family
GWQ43_00785	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GWQ43_00790	COG0183	Belongs to the thiolase family
GWQ43_00795	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
GWQ43_00800	COG1960	acyl-CoA dehydrogenase activity
GWQ43_00820	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GWQ43_00830	COG0018	arginyl-trna synthetase
GWQ43_00850	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GWQ43_00865	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
GWQ43_00870	COG4774	siderophore transport
GWQ43_00875	COG0066	3-isopropylmalate dehydratase activity
GWQ43_00880	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
GWQ43_00885	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GWQ43_00890	COG1804	L-carnitine dehydratase bile acid-inducible protein F
GWQ43_00895	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
GWQ43_00905	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
GWQ43_00910	COG1335	isochorismatase
GWQ43_00915	COG0583	DNA-binding transcription factor activity
GWQ43_00935	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
GWQ43_00940	COG1280	lysine exporter protein (LysE YggA)
GWQ43_00945	COG0513	Belongs to the DEAD box helicase family
GWQ43_00955	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
GWQ43_00970	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
GWQ43_00985	COG0154	amidase activity
GWQ43_01000	COG0583	DNA-binding transcription factor activity
GWQ43_01030	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
GWQ43_01035	COG1127	ABC transporter
GWQ43_01040	COG3218	ABC-type transport auxiliary lipoprotein component
GWQ43_01040	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
GWQ43_01055	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GWQ43_01060	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
GWQ43_01070	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
GWQ43_01100	COG0583	DNA-binding transcription factor activity
GWQ43_01120	COG3093	addiction module antidote protein HigA
GWQ43_01145	COG2358	TRAP transporter, solute receptor (TAXI family
GWQ43_01155	COG0564	pseudouridine synthase activity
GWQ43_01160	COG0252	asparaginase activity
GWQ43_01185	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
GWQ43_01190	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
GWQ43_01195	COG3181	Tripartite tricarboxylate transporter family receptor
GWQ43_01215	COG0559	Belongs to the binding-protein-dependent transport system permease family
GWQ43_01240	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GWQ43_01250	COG3712	iron ion homeostasis
GWQ43_01270	COG0758	DNA mediated transformation
GWQ43_01275	COG0242	peptide deformylase activity
GWQ43_01280	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
GWQ43_01285	COG0697	spore germination
GWQ43_01300	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
GWQ43_01315	COG4336	lyase activity
GWQ43_01320	COG0583	DNA-binding transcription factor activity
GWQ43_01325	COG0859	PFAM glycosyl transferase family 9
GWQ43_01335	COG1278	Cold shock
GWQ43_01340	COG1210	Utp--glucose-1-phosphate uridylyltransferase
GWQ43_01345	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
GWQ43_01350	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
GWQ43_01350	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
GWQ43_01360	COG1686	Belongs to the peptidase S11 family
GWQ43_01370	COG2921	Belongs to the UPF0250 family
GWQ43_01375	COG0321	lipoyl(octanoyl) transferase activity
GWQ43_01395	COG1024	Enoyl-CoA hydratase
GWQ43_01400	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
GWQ43_01410	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
GWQ43_01455	COG0826	peptidase U32
GWQ43_01465	COG3154	lipid carrier protein
GWQ43_01490	COG0134	indole-3-glycerol-phosphate synthase activity
GWQ43_01495	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
GWQ43_01500	COG0512	Glutamine amidotransferase of anthranilate synthase
GWQ43_01510	COG0546	phosphoglycolate phosphatase activity
GWQ43_01520	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
GWQ43_01525	COG2967	ApaG domain
GWQ43_01530	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
GWQ43_01535	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GWQ43_01540	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GWQ43_01550	COG0840	transmembrane signaling receptor activity
GWQ43_01560	COG1028	Short-chain dehydrogenase reductase Sdr
GWQ43_01565	COG1535	isochorismatase
GWQ43_01565	COG3433	isochorismatase activity
GWQ43_01570	COG1169	isochorismate synthase
GWQ43_01585	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
GWQ43_01585	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GWQ43_01590	COG1535	isochorismatase
GWQ43_01590	COG3433	isochorismatase activity
GWQ43_01595	COG1021	2,3-dihydroxybenzoate-AMP ligase
GWQ43_01625	COG0683	leucine binding
GWQ43_01640	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GWQ43_01675	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
GWQ43_01680	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GWQ43_01685	COG2819	hydrolase of the alpha beta superfamily
GWQ43_01690	COG0513	Belongs to the DEAD box helicase family
GWQ43_01695	COG2814	Major facilitator Superfamily
GWQ43_01705	COG0583	DNA-binding transcription factor activity
GWQ43_01715	COG1253	flavin adenine dinucleotide binding
GWQ43_01750	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GWQ43_01765	COG2311	Membrane
GWQ43_01800	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
GWQ43_01820	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GWQ43_01825	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
GWQ43_01835	COG0583	DNA-binding transcription factor activity
GWQ43_01840	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GWQ43_01850	COG0765	amino acid transport
GWQ43_01855	COG0765	amino acid transport
GWQ43_01860	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GWQ43_01870	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
GWQ43_01885	COG3391	amine dehydrogenase activity
GWQ43_01895	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
GWQ43_01920	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
GWQ43_01925	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
GWQ43_01930	COG0210	DNA helicase
GWQ43_01945	COG0070	glutamate synthase
GWQ43_01945	COG0067	glutamate synthase
GWQ43_01945	COG0069	glutamate synthase activity
GWQ43_01950	COG1024	Enoyl-CoA hydratase
GWQ43_01960	COG1804	L-carnitine dehydratase bile acid-inducible protein F
GWQ43_01965	COG1250	3-hydroxyacyl-CoA dehydrogenase
GWQ43_01995	COG2918	glutathione biosynthetic process
GWQ43_02005	COG2197	response regulator
GWQ43_02010	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
GWQ43_02020	COG2223	nitrite transmembrane transporter activity
GWQ43_02025	COG2860	membrane
GWQ43_02030	COG1346	cytolysis
GWQ43_02045	COG0251	oxidation-reduction process
GWQ43_02080	COG1280	lysine exporter protein (LysE YggA)
GWQ43_02090	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GWQ43_02105	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
GWQ43_02120	COG2096	Adenosyltransferase
GWQ43_02135	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
GWQ43_02140	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
GWQ43_02150	COG0523	cobalamin synthesis protein
GWQ43_02155	COG0735	belongs to the Fur family
GWQ43_02165	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GWQ43_02170	COG0803	Belongs to the bacterial solute-binding protein 9 family
GWQ43_02175	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
GWQ43_02185	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
GWQ43_02190	COG1560	Kdo2-lipid A biosynthetic process
GWQ43_02200	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
GWQ43_02205	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
GWQ43_02210	COG1950	PFAM Membrane protein of
GWQ43_02245	COG0275	rRNA processing
GWQ43_02250	COG0730	response to heat
GWQ43_02255	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
GWQ43_02260	COG0129	dihydroxy-acid dehydratase activity
GWQ43_02270	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
GWQ43_02280	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
GWQ43_02295	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
GWQ43_02315	COG3181	Tripartite tricarboxylate transporter family receptor
GWQ43_02325	COG0628	permease
GWQ43_02335	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
GWQ43_02340	COG0656	L-ascorbic acid biosynthetic process
GWQ43_02345	COG2814	Major facilitator Superfamily
GWQ43_02350	COG0583	DNA-binding transcription factor activity
GWQ43_02360	COG3685	Protein conserved in bacteria
GWQ43_02380	COG1846	Transcriptional regulator
GWQ43_02395	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GWQ43_02405	COG0789	Transcriptional regulator
GWQ43_02415	COG4774	siderophore transport
GWQ43_02420	COG4607	ABC-type enterochelin transport system periplasmic component
GWQ43_02425	COG4604	ABC transporter, ATP-binding protein
GWQ43_02430	COG4605	iron ion homeostasis
GWQ43_02435	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GWQ43_02450	COG0277	FAD linked oxidase domain protein
GWQ43_02455	COG1304	FMN binding
GWQ43_02460	COG2186	Transcriptional regulator
GWQ43_02480	COG2188	Transcriptional regulator
GWQ43_02485	COG1522	sequence-specific DNA binding
GWQ43_02490	COG3844	kynureninase activity
GWQ43_02495	COG1113	amino acid transport
GWQ43_02530	COG3181	Tripartite tricarboxylate transporter family receptor
GWQ43_02535	COG1349	DNA-binding transcription factor activity
GWQ43_02540	COG3842	ATPase activity
GWQ43_02555	COG0395	ABC-type sugar transport system, permease component
GWQ43_02580	COG0861	Integral membrane protein TerC family
GWQ43_02585	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GWQ43_02595	COG1671	Belongs to the UPF0178 family
GWQ43_02605	COG2161	toxin-antitoxin pair type II binding
GWQ43_02615	COG1418	mRNA catabolic process
GWQ43_02625	COG4948	Mandelate Racemase Muconate Lactonizing
GWQ43_02635	COG0477	Major facilitator Superfamily
GWQ43_02650	COG0154	amidase activity
GWQ43_02660	COG0583	DNA-binding transcription factor activity
GWQ43_02685	COG0326	Molecular chaperone. Has ATPase activity
GWQ43_02690	COG4774	siderophore transport
GWQ43_02695	COG3128	pkhd-type hydroxylase
GWQ43_02720	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
GWQ43_02725	COG1652	LysM domain
GWQ43_02740	COG0220	tRNA (guanine-N7-)-methyltransferase activity
GWQ43_02750	COG0582	viral genome integration into host DNA
GWQ43_02800	COG0629	single-stranded DNA binding
GWQ43_02805	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GWQ43_02965	COG2003	Belongs to the UPF0758 family
GWQ43_03095	COG0789	Transcriptional regulator
GWQ43_03105	COG2608	mercury ion transmembrane transporter activity
GWQ43_03110	COG2608	mercury ion transmembrane transporter activity
GWQ43_03115	COG0789	Transcriptional regulator
GWQ43_03125	COG1120	ATPase activity
GWQ43_03140	COG3586	endonuclease activity
GWQ43_03150	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GWQ43_03160	COG0583	DNA-binding transcription factor activity
GWQ43_03170	COG0464	growth
GWQ43_03200	COG1535	isochorismatase
GWQ43_03200	COG3433	isochorismatase activity
GWQ43_03225	COG0583	DNA-binding transcription factor activity
GWQ43_03230	COG0387	Pfam Sodium calcium exchanger
GWQ43_03245	COG0477	Major facilitator Superfamily
GWQ43_03250	COG0235	Class ii aldolase
GWQ43_03260	COG3391	amine dehydrogenase activity
GWQ43_03265	COG0590	tRNA wobble adenosine to inosine editing
GWQ43_03270	COG3257	ureidoglycine aminohydrolase activity
GWQ43_03275	COG0583	DNA-binding transcription factor activity
GWQ43_03280	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
GWQ43_03285	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GWQ43_03285	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GWQ43_03295	COG0489	protein tyrosine kinase activity
GWQ43_03315	COG1982	Orn Lys Arg decarboxylase major
GWQ43_03320	COG2081	HI0933 family
GWQ43_03325	COG0509	glycine decarboxylation via glycine cleavage system
GWQ43_03335	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
GWQ43_03340	COG1765	OsmC-like protein
GWQ43_03345	COG3278	Belongs to the heme-copper respiratory oxidase family
GWQ43_03370	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
GWQ43_03375	COG0469	pyruvate kinase activity
GWQ43_03380	COG3193	protein, possibly involved in utilization of glycolate and propanediol
GWQ43_03390	COG2084	Dehydrogenase
GWQ43_03395	COG3622	Belongs to the hyi family
GWQ43_03400	COG3960	tartronate-semialdehyde synthase activity
GWQ43_03405	COG0583	DNA-binding transcription factor activity
GWQ43_03415	COG2233	PERMEase
GWQ43_03420	COG1942	4-Oxalocrotonate Tautomerase
GWQ43_03425	COG0235	Class ii aldolase
GWQ43_03435	COG3648	Uricase
GWQ43_03435	COG3195	allantoin biosynthetic process
GWQ43_03445	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GWQ43_03450	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
GWQ43_03465	COG0438	transferase activity, transferring glycosyl groups
GWQ43_03475	COG0438	transferase activity, transferring glycosyl groups
GWQ43_03485	COG0277	FAD linked oxidase domain protein
GWQ43_03495	COG0179	Fumarylacetoacetate (FAA) hydrolase
GWQ43_03500	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
GWQ43_03510	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GWQ43_03520	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
GWQ43_03530	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
GWQ43_03545	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
GWQ43_03550	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
GWQ43_03555	COG0193	aminoacyl-tRNA hydrolase activity
GWQ43_03565	COG0012	GTP binding
GWQ43_03570	COG0582	viral genome integration into host DNA
GWQ43_03580	COG1205	dead DEAH box helicase
GWQ43_03580	COG1111	helicase
GWQ43_03585	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GWQ43_03650	COG0488	(ABC) transporter
GWQ43_03665	COG0288	reversible hydration of carbon dioxide
GWQ43_03670	COG0583	DNA-binding transcription factor activity
GWQ43_03690	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GWQ43_03700	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
GWQ43_03710	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GWQ43_03715	COG3088	subunit of a heme lyase
GWQ43_03720	COG4235	cytochrome complex assembly
GWQ43_03725	COG0785	Cytochrome C biogenesis protein
GWQ43_03735	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
GWQ43_03735	COG2169	Transcriptional regulator
GWQ43_03755	COG0559	Belongs to the binding-protein-dependent transport system permease family
GWQ43_03765	COG0411	ABC transporter
GWQ43_03775	COG1858	cytochrome C peroxidase
GWQ43_03780	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GWQ43_03785	COG1959	2 iron, 2 sulfur cluster binding
GWQ43_03790	COG2346	COG2346, Truncated hemoglobins
GWQ43_03795	COG0463	Glycosyl transferase, family 2
GWQ43_03835	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
GWQ43_03840	COG3383	formate dehydrogenase (NAD+) activity
GWQ43_03855	COG1910	domain protein
GWQ43_03860	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
GWQ43_03870	COG0303	'Molybdopterin
GWQ43_03875	COG0521	Mo-molybdopterin cofactor biosynthetic process
GWQ43_03880	COG0314	molybdopterin synthase activity
GWQ43_03890	COG0315	cyclic pyranopterin monophosphate synthase activity
GWQ43_03920	COG0678	peroxiredoxin activity
GWQ43_03935	COG0697	spore germination
GWQ43_03940	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
GWQ43_03975	COG2814	Major facilitator Superfamily
GWQ43_04015	COG0815	Transfers the fatty acyl group on membrane lipoproteins
GWQ43_04020	COG4535	Mg2 and Co2 transporter CorC
GWQ43_04025	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
GWQ43_04030	COG1702	phosphate starvation-inducible protein PhoH
GWQ43_04035	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GWQ43_04050	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GWQ43_04055	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GWQ43_04060	COG1862	Preprotein translocase
GWQ43_04065	COG0343	queuine tRNA-ribosyltransferase activity
GWQ43_04070	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
GWQ43_04075	COG2027	D-alanyl-D-alanine carboxypeptidase
GWQ43_04080	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
GWQ43_04090	COG4575	ribosome binding
GWQ43_04105	COG0583	DNA-binding transcription factor activity
GWQ43_04120	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GWQ43_04135	COG0154	amidase activity
GWQ43_04145	COG0477	Major facilitator Superfamily
GWQ43_04160	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
GWQ43_04170	COG0436	Aminotransferase
GWQ43_04180	COG0280	phosphate acetyltransferase
GWQ43_04180	COG0281	malic enzyme
GWQ43_04190	COG2732	(Barnase) inhibitor
GWQ43_04195	COG1385	rRNA (uridine-N3-)-methyltransferase activity
GWQ43_04200	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
GWQ43_04205	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GWQ43_04210	COG0126	phosphoglycerate kinase activity
GWQ43_04230	COG0521	Mo-molybdopterin cofactor biosynthetic process
GWQ43_04240	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
GWQ43_04245	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
GWQ43_04250	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
GWQ43_04255	COG0009	L-threonylcarbamoyladenylate synthase
GWQ43_04260	COG0596	Alpha beta hydrolase
GWQ43_04265	COG2030	dehydratase
GWQ43_04265	COG1012	belongs to the aldehyde dehydrogenase family
GWQ43_04270	COG1960	acyl-CoA dehydrogenase activity
GWQ43_04280	COG0405	Gamma-glutamyltransferase
GWQ43_04290	COG0579	oxidoreductase
GWQ43_04295	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
GWQ43_04300	COG0259	pyridoxamine-phosphate oxidase activity
GWQ43_04310	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
GWQ43_04325	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
GWQ43_04330	COG1215	transferase activity, transferring glycosyl groups
GWQ43_04340	COG0488	(ABC) transporter
GWQ43_04360	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
GWQ43_04365	COG2894	cell division
GWQ43_04375	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GWQ43_04380	COG1271	oxidase subunit
GWQ43_04385	COG1294	oxidase, subunit
GWQ43_04390	COG0038	chloride channel
GWQ43_04400	COG0514	ATP-dependent DNA helicase (RecQ)
GWQ43_04405	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GWQ43_04410	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GWQ43_04415	COG0633	Ferredoxin
GWQ43_04430	COG2001	Belongs to the MraZ family
GWQ43_04435	COG0275	rRNA processing
GWQ43_04440	COG3116	cell division
GWQ43_04450	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
GWQ43_04455	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GWQ43_04460	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
GWQ43_04470	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
GWQ43_04475	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GWQ43_04480	COG1181	Belongs to the D-alanine--D-alanine ligase family
GWQ43_04485	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
GWQ43_04500	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
GWQ43_04510	COG0741	lytic transglycosylase activity
GWQ43_04510	COG0739	heme binding
GWQ43_04510	COG1196	nuclear chromosome segregation
GWQ43_04515	COG0653	protein targeting
GWQ43_04525	COG2239	Acts as a magnesium transporter
GWQ43_04535	COG1473	amidohydrolase
GWQ43_04540	COG0318	PFAM AMP-dependent synthetase and ligase
GWQ43_04550	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
GWQ43_04550	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GWQ43_04565	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
GWQ43_04570	COG2011	ABC-type metal ion transport system permease component
GWQ43_04580	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GWQ43_04585	COG0765	amino acid transport
GWQ43_04590	COG1126	abc transporter atp-binding protein
GWQ43_04615	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GWQ43_04620	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
GWQ43_04625	COG0700	Nucleoside recognition
GWQ43_04640	COG0204	Acyl-transferase
GWQ43_04645	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
GWQ43_04650	COG0751	glycine-tRNA ligase activity
GWQ43_04655	COG0752	glycyl-tRNA synthetase alpha subunit
GWQ43_04660	COG1024	Enoyl-CoA hydratase
GWQ43_04670	COG1309	transcriptional regulator
GWQ43_04695	COG1573	uracil-dna glycosylase
GWQ43_04700	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
GWQ43_04705	COG0617	tRNA 3'-terminal CCA addition
GWQ43_04715	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
GWQ43_04720	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
GWQ43_04730	COG1953	Uracil, thiamine, allantoin
GWQ43_04735	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
GWQ43_04740	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
GWQ43_04745	COG0586	Pfam SNARE associated Golgi protein
GWQ43_04750	COG0860	N-Acetylmuramoyl-L-alanine amidase
GWQ43_04755	COG0802	atpase or kinase
GWQ43_04765	COG3181	Tripartite tricarboxylate transporter family receptor
GWQ43_04800	COG0463	Glycosyl transferase, family 2
GWQ43_04805	COG0281	malic enzyme
GWQ43_04805	COG0280	phosphate acetyltransferase
GWQ43_04810	COG0583	DNA-binding transcription factor activity
GWQ43_04815	COG1012	belongs to the aldehyde dehydrogenase family
GWQ43_04820	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GWQ43_04870	COG1733	regulation of RNA biosynthetic process
GWQ43_04875	COG2910	NAD(P)H-binding
GWQ43_04885	COG2223	nitrite transmembrane transporter activity
GWQ43_04890	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
GWQ43_04895	COG4974	Belongs to the 'phage' integrase family
GWQ43_04900	COG0725	ABC transporter, periplasmic molybdate-binding protein
GWQ43_04905	COG4149	molybdate abc transporter
GWQ43_04910	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
GWQ43_04925	COG1074	ATP-dependent DNA helicase activity
GWQ43_04960	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GWQ43_04980	COG3391	amine dehydrogenase activity
GWQ43_04985	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
GWQ43_04990	COG0505	Belongs to the CarA family
GWQ43_04995	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
GWQ43_05020	COG2233	PERMEase
GWQ43_05025	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GWQ43_05030	COG1534	Rna-binding protein
GWQ43_05035	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
GWQ43_05040	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GWQ43_05045	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
GWQ43_05050	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GWQ43_05060	COG0248	Ppx GppA phosphatase
GWQ43_05065	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
GWQ43_05085	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GWQ43_05090	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GWQ43_05105	COG0745	RESPONSE REGULATOR receiver
GWQ43_05110	COG2205	protein histidine kinase activity
GWQ43_05140	COG1231	oxidoreductase activity
GWQ43_05145	COG2010	Cytochrome c
GWQ43_05150	COG2323	membrane
GWQ43_05165	COG1368	sulfuric ester hydrolase activity
GWQ43_05195	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GWQ43_05200	COG3327	negative regulation of DNA-templated transcription, initiation
GWQ43_05205	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GWQ43_05220	COG0009	L-threonylcarbamoyladenylate synthase
GWQ43_05225	COG1994	Peptidase M50
GWQ43_05230	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GWQ43_05235	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
GWQ43_05250	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
GWQ43_05260	COG0156	8-amino-7-oxononanoate synthase activity
GWQ43_05265	COG2124	cytochrome p450
GWQ43_05270	COG3135	benzoate transporter
GWQ43_05280	COG2850	peptidyl-arginine hydroxylation
GWQ43_05290	COG3391	amine dehydrogenase activity
GWQ43_05330	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GWQ43_05335	COG0577	efflux transmembrane transporter activity
GWQ43_05335	COG1136	(ABC) transporter
GWQ43_05340	COG1538	Outer membrane efflux protein
GWQ43_05345	COG0363	glucosamine-6-phosphate deaminase activity
GWQ43_05350	COG1132	(ABC) transporter
GWQ43_05360	COG3181	Tripartite tricarboxylate transporter family receptor
GWQ43_05370	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GWQ43_05380	COG0668	transmembrane transport
GWQ43_05425	COG0154	amidase activity
GWQ43_05430	COG2031	fatty acid transporter
GWQ43_05450	COG1253	flavin adenine dinucleotide binding
GWQ43_05455	COG1968	undecaprenyl-diphosphatase activity
GWQ43_05475	COG0215	cysteine-tRNA ligase activity
GWQ43_05485	COG0825	malonyl-CoA metabolic process
GWQ43_05490	COG0037	tRNA processing
GWQ43_05510	COG0330	HflC and HflK could
GWQ43_05580	COG1201	RNA secondary structure unwinding
GWQ43_05595	COG2003	Belongs to the UPF0758 family
GWQ43_05665	COG2948	multi-organism process
GWQ43_05770	COG4208	sulfate ABC transporter
GWQ43_05775	COG3842	ATPase activity
GWQ43_05785	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
GWQ43_05810	COG0745	RESPONSE REGULATOR receiver
GWQ43_05815	COG4773	Receptor
GWQ43_05830	COG1304	FMN binding
GWQ43_05835	COG0435	Glutathione S-transferase
GWQ43_05840	COG0655	NAD(P)H dehydrogenase (quinone) activity
GWQ43_05860	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
GWQ43_05865	COG2363	Small membrane protein
GWQ43_05870	COG0598	Magnesium transport protein CorA
GWQ43_05875	COG1960	acyl-CoA dehydrogenase activity
GWQ43_05885	COG0747	negative chemotaxis
GWQ43_05895	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GWQ43_05900	COG4172	Belongs to the ABC transporter superfamily
GWQ43_05910	COG3284	Transcriptional regulator
GWQ43_05915	COG1012	belongs to the aldehyde dehydrogenase family
GWQ43_05920	COG1454	alcohol dehydrogenase
GWQ43_05950	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
GWQ43_05960	COG0183	Belongs to the thiolase family
GWQ43_05975	COG1028	Short-chain dehydrogenase reductase Sdr
GWQ43_05980	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
GWQ43_06005	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
GWQ43_06035	COG3829	transcription factor binding
GWQ43_06055	COG0039	L-malate dehydrogenase activity
GWQ43_06060	COG2188	Transcriptional regulator
GWQ43_06065	COG2009	succinate dehydrogenase
GWQ43_06075	COG1053	succinate dehydrogenase
GWQ43_06080	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
GWQ43_06085	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
GWQ43_06090	COG0372	Belongs to the citrate synthase family
GWQ43_06095	COG2186	Transcriptional regulator
GWQ43_06100	COG1620	l-lactate permease
GWQ43_06105	COG0280	phosphate acetyltransferase
GWQ43_06105	COG0281	malic enzyme
GWQ43_06110	COG0567	Dehydrogenase, E1 component
GWQ43_06115	COG0508	dehydrogenase complex catalyzes the overall conversion of
GWQ43_06120	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GWQ43_06125	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
GWQ43_06145	COG2183	response to ionizing radiation
GWQ43_06150	COG1199	ATP-dependent helicase activity
GWQ43_06160	COG1733	regulation of RNA biosynthetic process
GWQ43_06180	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
GWQ43_06180	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GWQ43_06195	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
GWQ43_06195	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
GWQ43_06210	COG0564	pseudouridine synthase activity
GWQ43_06220	COG3243	poly(R)-hydroxyalkanoic acid synthase
GWQ43_06225	COG1028	Short-chain dehydrogenase reductase Sdr
GWQ43_06230	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
GWQ43_06255	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
GWQ43_06260	COG1187	pseudouridine synthase activity
GWQ43_06265	COG0779	Required for maturation of 30S ribosomal subunits
GWQ43_06270	COG0195	Participates in both transcription termination and antitermination
GWQ43_06270	COG2251	uridine kinase activity
GWQ43_06275	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
GWQ43_06280	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
GWQ43_06285	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
GWQ43_06295	COG0446	pyridine nucleotide-disulphide oxidoreductase
GWQ43_06305	COG4160	amino acid transport
GWQ43_06310	COG4215	(ABC) transporter
GWQ43_06330	COG1283	sodium-dependent phosphate transmembrane transporter activity
GWQ43_06340	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
GWQ43_06350	COG0456	acetyltransferase
GWQ43_06355	COG0501	Belongs to the peptidase M48B family
GWQ43_06370	COG1722	exodeoxyribonuclease VII activity
GWQ43_06375	COG0142	geranyltranstransferase activity
GWQ43_06385	COG1469	GTP cyclohydrolase I activity
GWQ43_06390	COG0360	Binds together with S18 to 16S ribosomal RNA
GWQ43_06395	COG2965	DNA replication, synthesis of RNA primer
GWQ43_06400	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
GWQ43_06410	COG0305	Participates in initiation and elongation during chromosome replication
GWQ43_06420	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
GWQ43_06425	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
GWQ43_06430	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
GWQ43_06440	COG0436	Aminotransferase
GWQ43_06455	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GWQ43_06460	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
GWQ43_06465	COG1562	ergosterol biosynthetic process
GWQ43_06470	COG1562	ergosterol biosynthetic process
GWQ43_06475	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GWQ43_06480	COG1028	Short-chain dehydrogenase reductase Sdr
GWQ43_06505	COG3842	ATPase activity
GWQ43_06510	COG1176	ABC-type spermidine putrescine transport system, permease component I
GWQ43_06515	COG1177	transmembrane transport
GWQ43_06520	COG1393	Belongs to the ArsC family
GWQ43_06525	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
GWQ43_06530	COG0704	Plays a role in the regulation of phosphate uptake
GWQ43_06535	COG5001	Diguanylate cyclase
GWQ43_06540	COG0659	secondary active sulfate transmembrane transporter activity
GWQ43_06545	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
GWQ43_06550	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
GWQ43_06550	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
GWQ43_06555	COG1643	Atp-dependent helicase
GWQ43_06565	COG0438	transferase activity, transferring glycosyl groups
GWQ43_06570	COG0726	polysaccharide deacetylase
GWQ43_06585	COG0438	transferase activity, transferring glycosyl groups
GWQ43_06610	COG1132	(ABC) transporter
GWQ43_06625	COG1530	ribonuclease E activity
GWQ43_06660	COG2186	Transcriptional regulator
GWQ43_06665	COG0277	FAD linked oxidase domain protein
GWQ43_06670	COG0277	FAD linked oxidase domain protein
GWQ43_06675	COG0247	lactate metabolic process
GWQ43_06710	COG1283	sodium-dependent phosphate transmembrane transporter activity
GWQ43_06725	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
GWQ43_06735	COG0697	spore germination
GWQ43_06755	COG3094	Invasion gene expression up-regulator, SirB
GWQ43_06765	COG0640	Transcriptional regulator
GWQ43_06790	COG0659	secondary active sulfate transmembrane transporter activity
GWQ43_06795	COG1262	PFAM Formylglycine-generating sulfatase enzyme
GWQ43_06805	COG2314	TM2 domain
GWQ43_06810	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
GWQ43_06815	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
GWQ43_06820	COG0791	NLP P60 protein
GWQ43_06840	COG1360	Flagellar Motor Protein
GWQ43_06850	COG0835	chemotaxis
GWQ43_06855	COG0840	transmembrane signaling receptor activity
GWQ43_06860	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
GWQ43_06870	COG0745	RESPONSE REGULATOR receiver
GWQ43_06875	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
GWQ43_06885	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
GWQ43_06910	COG1815	bacterial-type flagellum-dependent cell motility
GWQ43_06915	COG1558	bacterial-type flagellum-dependent cell motility
GWQ43_06920	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
GWQ43_06960	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GWQ43_06985	COG2176	DNA-directed DNA polymerase activity
GWQ43_06995	COG1987	bacterial-type flagellum assembly
GWQ43_07010	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GWQ43_07035	COG1157	protein secretion by the type III secretion system
GWQ43_07050	COG1766	The M ring may be actively involved in energy transduction
GWQ43_07055	COG1677	Flagellar hook-basal body complex protein FliE
GWQ43_07060	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
GWQ43_07085	COG1334	flagellar protein FlaG
GWQ43_07090	COG1191	sigma factor activity
GWQ43_07140	COG1262	PFAM Formylglycine-generating sulfatase enzyme
GWQ43_07160	COG2733	membrane
GWQ43_07165	COG0840	transmembrane signaling receptor activity
GWQ43_07170	COG0840	transmembrane signaling receptor activity
GWQ43_07195	COG2610	gluconate transmembrane transporter activity
GWQ43_07215	COG4974	Belongs to the 'phage' integrase family
GWQ43_07255	COG4128	Pfam Zonular occludens toxin
GWQ43_07270	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GWQ43_07275	COG3657	addiction module killer protein
GWQ43_07280	COG4521	taurine ABC transporter
GWQ43_07285	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
GWQ43_07290	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GWQ43_07295	COG1028	Short-chain dehydrogenase reductase Sdr
GWQ43_07300	COG0583	DNA-binding transcription factor activity
GWQ43_07330	COG2824	Alkylphosphonate utilization operon protein PhnA
GWQ43_07345	COG4771	TonB-dependent receptor
GWQ43_07350	COG1858	cytochrome C peroxidase
GWQ43_07360	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
GWQ43_07370	COG1113	amino acid transport
GWQ43_07390	COG0583	DNA-binding transcription factor activity
GWQ43_07395	COG3755	Protein conserved in bacteria
GWQ43_07400	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
GWQ43_07440	COG0446	pyridine nucleotide-disulphide oxidoreductase
GWQ43_07465	COG1278	Cold shock
GWQ43_07470	COG0642	Histidine kinase
GWQ43_07480	COG3278	Belongs to the heme-copper respiratory oxidase family
GWQ43_07490	COG2863	cytochrome
GWQ43_07495	COG3258	Cytochrome c
GWQ43_07540	COG0025	NhaP-type Na H and K H
GWQ43_07555	COG1289	transmembrane transporter activity
GWQ43_07560	COG2252	PERMEase
GWQ43_07580	COG1999	signal sequence binding
GWQ43_07595	COG0069	glutamate synthase activity
GWQ43_07605	COG1846	Transcriptional regulator
GWQ43_07615	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
GWQ43_07655	COG1028	Short-chain dehydrogenase reductase Sdr
GWQ43_07665	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
GWQ43_07665	COG3264	Mechanosensitive ion channel
GWQ43_07670	COG3264	Mechanosensitive ion channel
GWQ43_07670	COG1511	domain protein
GWQ43_07675	COG0477	Major facilitator Superfamily
GWQ43_07690	COG1396	sequence-specific DNA binding
GWQ43_07695	COG3437	response regulator, receiver
GWQ43_07700	COG2198	Histidine kinase
GWQ43_07700	COG2205	protein histidine kinase activity
GWQ43_07700	COG0784	Response regulator, receiver
GWQ43_07705	COG2239	Acts as a magnesium transporter
GWQ43_07715	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
GWQ43_07720	COG1490	D-aminoacyl-tRNA deacylase activity
GWQ43_07735	COG0456	acetyltransferase
GWQ43_07745	COG0501	Belongs to the peptidase M48B family
GWQ43_07750	COG2814	Major facilitator Superfamily
GWQ43_07760	COG4115	mRNA cleavage
GWQ43_07765	COG2161	toxin-antitoxin pair type II binding
GWQ43_07895	COG3772	lysozyme
GWQ43_07950	COG3706	GGDEF domain
GWQ43_07965	COG1522	sequence-specific DNA binding
GWQ43_07970	COG0626	cystathionine gamma-synthase activity
GWQ43_07980	COG0494	nUDIX hydrolase
GWQ43_07985	COG2832	Protein of unknown function (DUF454)
GWQ43_07995	COG0137	argininosuccinate synthase activity
GWQ43_08000	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
GWQ43_08005	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
GWQ43_08025	COG1609	Transcriptional regulator
GWQ43_08035	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
GWQ43_08045	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
GWQ43_08050	COG2205	protein histidine kinase activity
GWQ43_08055	COG0745	RESPONSE REGULATOR receiver
GWQ43_08060	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
GWQ43_08070	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GWQ43_08075	COG0268	Binds directly to 16S ribosomal RNA
GWQ43_08080	COG0728	peptidoglycan biosynthetic process
GWQ43_08090	COG0563	adenylate kinase activity
GWQ43_08095	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
GWQ43_08100	COG2835	tetraacyldisaccharide 4'-kinase activity
GWQ43_08105	COG1663	tetraacyldisaccharide 4'-kinase activity
GWQ43_08110	COG0848	biopolymer transport protein
GWQ43_08115	COG0811	peptide transport
GWQ43_08120	COG1570	exodeoxyribonuclease VII activity
GWQ43_08125	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
GWQ43_08135	COG0183	Belongs to the thiolase family
GWQ43_08145	COG1278	Cold shock
GWQ43_08150	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
GWQ43_08155	COG0542	response to heat
GWQ43_08160	COG2995	paraquat-inducible protein a
GWQ43_08165	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
GWQ43_08165	COG3008	intermembrane lipid transfer
GWQ43_08185	COG0559	Belongs to the binding-protein-dependent transport system permease family
GWQ43_08225	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
GWQ43_08230	COG0756	dUTP diphosphatase activity
GWQ43_08240	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
GWQ43_08245	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
GWQ43_08250	COG0196	riboflavin kinase activity
GWQ43_08255	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
GWQ43_08260	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GWQ43_08260	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GWQ43_08270	COG0210	DNA helicase
GWQ43_08325	COG0488	(ABC) transporter
GWQ43_08330	COG2890	protein-(glutamine-N5) methyltransferase activity
GWQ43_08335	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GWQ43_08340	COG2171	N-acyltransferase activity
GWQ43_08350	COG2207	Transcriptional regulator
GWQ43_08360	COG0471	metal ion transport
GWQ43_08360	COG3273	potassium ion transport
GWQ43_08410	COG0789	Transcriptional regulator
GWQ43_08590	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
GWQ43_08650	COG2135	peptidase activity
GWQ43_08675	COG1804	L-carnitine dehydratase bile acid-inducible protein F
GWQ43_08680	COG0544	peptidyl-prolyl cis-trans isomerase activity
GWQ43_08685	COG0740	serine-type endopeptidase activity
GWQ43_08695	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
GWQ43_08715	COG0556	nucleotide-excision repair
GWQ43_08720	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GWQ43_08730	COG1104	cysteine desulfurase activity
GWQ43_08740	COG0316	Belongs to the HesB IscA family
GWQ43_08755	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
GWQ43_08760	COG4221	oxidoreductase activity
GWQ43_08770	COG0840	transmembrane signaling receptor activity
GWQ43_08775	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
GWQ43_08780	COG0697	spore germination
GWQ43_08785	COG0385	Bile acid
GWQ43_08795	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
GWQ43_08810	COG1136	(ABC) transporter
GWQ43_08815	COG0084	hydrolase, TatD family'
GWQ43_08830	COG0613	PHP domain protein
GWQ43_08840	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GWQ43_08840	COG0047	phosphoribosylformylglycinamidine synthase activity
GWQ43_08865	COG0519	Catalyzes the synthesis of GMP from XMP
GWQ43_08865	COG0518	GMP synthase (glutamine-hydrolyzing) activity
GWQ43_08900	COG3971	2-oxopent-4-enoate hydratase activity
GWQ43_08905	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
GWQ43_08920	COG0583	DNA-binding transcription factor activity
GWQ43_08935	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
GWQ43_08945	COG1960	acyl-CoA dehydrogenase activity
GWQ43_08950	COG0523	cobalamin synthesis protein
GWQ43_08955	COG1469	GTP cyclohydrolase I activity
GWQ43_08960	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
GWQ43_08970	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
GWQ43_08975	COG0735	belongs to the Fur family
GWQ43_08980	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
GWQ43_09000	COG0745	RESPONSE REGULATOR receiver
GWQ43_09005	COG2207	Transcriptional regulator
GWQ43_09025	COG0583	DNA-binding transcription factor activity
GWQ43_09030	COG1289	transmembrane transporter activity
GWQ43_09040	COG1566	PFAM secretion protein HlyD family protein
GWQ43_09050	COG1942	4-Oxalocrotonate Tautomerase
GWQ43_09065	COG2070	2-Nitropropane dioxygenase
GWQ43_09100	COG1309	transcriptional regulator
GWQ43_09125	COG0625	glutathione transferase activity
GWQ43_09130	COG0740	serine-type endopeptidase activity
GWQ43_09180	COG1804	L-carnitine dehydratase bile acid-inducible protein F
GWQ43_09190	COG1960	acyl-CoA dehydrogenase activity
GWQ43_09220	COG0640	Transcriptional regulator
GWQ43_09245	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GWQ43_09270	COG3485	protocatechuate 3,4-dioxygenase
GWQ43_09280	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
GWQ43_09285	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
GWQ43_09295	COG3135	benzoate transporter
GWQ43_09300	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
GWQ43_09305	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
GWQ43_09315	COG4555	ABC transporter
GWQ43_09325	COG2197	response regulator
GWQ43_09330	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
GWQ43_09355	COG1846	Transcriptional regulator
GWQ43_09360	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GWQ43_09365	COG2271	Major facilitator Superfamily
GWQ43_09375	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
GWQ43_09385	COG0697	spore germination
GWQ43_09410	COG3842	ATPase activity
GWQ43_09425	COG2205	protein histidine kinase activity
GWQ43_09440	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
GWQ43_09445	COG0667	Aldo Keto reductase
GWQ43_09465	COG2135	peptidase activity
GWQ43_09515	COG1272	protein, Hemolysin III
GWQ43_09520	COG3422	double-strand break repair
GWQ43_09550	COG0765	amino acid transport
GWQ43_09555	COG1126	abc transporter atp-binding protein
GWQ43_09605	COG2871	sodium ion transport
GWQ43_09635	COG2814	Major facilitator Superfamily
GWQ43_09640	COG1280	lysine exporter protein (LysE YggA)
GWQ43_09660	COG0402	S-adenosylhomocysteine deaminase activity
GWQ43_09690	COG0330	HflC and HflK could
GWQ43_09695	COG1585	Membrane protein implicated in regulation of membrane protease activity
GWQ43_09700	COG2226	methyltransferase
GWQ43_09710	COG3042	response to heat
GWQ43_09720	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GWQ43_09740	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
GWQ43_09745	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
GWQ43_09760	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GWQ43_09765	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GWQ43_09805	COG0291	Belongs to the bacterial ribosomal protein bL35 family
GWQ43_09810	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
GWQ43_09815	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
GWQ43_09820	COG0072	phenylalanine-tRNA ligase activity
GWQ43_09820	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GWQ43_09835	COG2833	Protein of unknown function (DUF455)
GWQ43_09845	COG5265	(ABC) transporter
GWQ43_09850	COG1959	2 iron, 2 sulfur cluster binding
GWQ43_09855	COG0719	Fe-S assembly protein
GWQ43_09860	COG0396	ATPase activity
GWQ43_09865	COG0719	Fe-S assembly protein
GWQ43_09875	COG0822	iron-sulfur transferase activity
GWQ43_09880	COG2151	metal-sulfur cluster biosynthetic enzyme
GWQ43_09900	COG1538	Outer membrane efflux protein
GWQ43_09930	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
GWQ43_09955	COG3436	PFAM IS66 Orf2 family protein
GWQ43_09980	COG0747	negative chemotaxis
GWQ43_09985	COG0601	transmembrane transport
GWQ43_09990	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GWQ43_09995	COG4172	Belongs to the ABC transporter superfamily
GWQ43_10005	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GWQ43_10050	COG0604	alcohol dehydrogenase
GWQ43_10055	COG2207	Transcriptional regulator
GWQ43_10060	COG3048	D-serine ammonia-lyase activity
GWQ43_10065	COG3258	Cytochrome c
GWQ43_10080	COG3949	Membrane
GWQ43_10090	COG1262	PFAM Formylglycine-generating sulfatase enzyme
GWQ43_10105	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GWQ43_10110	COG0569	domain protein
GWQ43_10115	COG1902	pentaerythritol trinitrate reductase activity
GWQ43_10125	COG1610	YqeY-like protein
GWQ43_10130	COG0587	DNA-directed DNA polymerase activity
GWQ43_10165	COG3181	Tripartite tricarboxylate transporter family receptor
GWQ43_10170	COG0583	DNA-binding transcription factor activity
GWQ43_10175	COG1686	Belongs to the peptidase S11 family
GWQ43_10190	COG1360	Flagellar Motor Protein
GWQ43_10200	COG1028	Short-chain dehydrogenase reductase Sdr
GWQ43_10205	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GWQ43_10210	COG4221	oxidoreductase activity
GWQ43_10220	COG0307	riboflavin synthase, alpha
GWQ43_10235	COG1301	dicarboxylic acid transport
GWQ43_10240	COG4191	Histidine kinase
GWQ43_10250	COG0583	DNA-binding transcription factor activity
GWQ43_10255	COG1053	succinate dehydrogenase
GWQ43_10350	COG3300	MHYT domain
GWQ43_10350	COG5001	Diguanylate cyclase
GWQ43_10415	COG2233	PERMEase
GWQ43_10420	COG0071	Belongs to the small heat shock protein (HSP20) family
GWQ43_10425	COG1473	amidohydrolase
GWQ43_10465	COG2816	NAD+ diphosphatase activity
GWQ43_10470	COG1561	YicC-like family, N-terminal region
GWQ43_10485	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
GWQ43_10490	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
GWQ43_10495	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GWQ43_10500	COG0174	glutamine synthetase
GWQ43_10505	COG2153	protein acetylation
GWQ43_10525	COG3842	ATPase activity
GWQ43_10530	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
GWQ43_10535	COG1840	ABC-type Fe3 transport system, periplasmic component
GWQ43_10550	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
GWQ43_10560	COG0783	Belongs to the Dps family
GWQ43_10570	COG3842	ATPase activity
GWQ43_10575	COG0395	ABC-type sugar transport system, permease component
GWQ43_10580	COG1175	transmembrane transport
GWQ43_10585	COG1653	transport
GWQ43_10600	COG0559	Belongs to the binding-protein-dependent transport system permease family
GWQ43_10620	COG0625	glutathione transferase activity
GWQ43_10630	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GWQ43_10635	COG1028	Short-chain dehydrogenase reductase Sdr
GWQ43_10640	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GWQ43_10645	COG0114	fumarate hydratase activity
GWQ43_10650	COG2133	pyrroloquinoline quinone binding
GWQ43_10655	COG2226	methyltransferase
GWQ43_10660	COG0589	response to stress
GWQ43_10670	COG2207	Transcriptional regulator
GWQ43_10685	COG1012	belongs to the aldehyde dehydrogenase family
GWQ43_10690	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GWQ43_10695	COG2807	transmembrane transport
GWQ43_10705	COG0583	DNA-binding transcription factor activity
GWQ43_10735	COG0583	DNA-binding transcription factor activity
GWQ43_10740	COG4974	Belongs to the 'phage' integrase family
GWQ43_10755	COG2132	Multicopper oxidase
GWQ43_10760	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
GWQ43_10775	COG1028	Short-chain dehydrogenase reductase Sdr
GWQ43_10805	COG3038	cytochrome b561
GWQ43_10815	COG2353	YceI-like domain
GWQ43_10820	COG1393	Belongs to the ArsC family
GWQ43_10825	COG0625	glutathione transferase activity
GWQ43_10845	COG0084	hydrolase, TatD family'
GWQ43_10850	COG0470	DNA polymerase III
GWQ43_10860	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
GWQ43_10880	COG1960	acyl-CoA dehydrogenase activity
GWQ43_10885	COG2914	Belongs to the UPF0125 (RnfH) family
GWQ43_10890	COG2867	negative regulation of translational initiation
GWQ43_10895	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
GWQ43_10900	COG1252	NADH dehydrogenase
GWQ43_10925	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GWQ43_10930	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
GWQ43_10935	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GWQ43_10945	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GWQ43_10950	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GWQ43_10960	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GWQ43_10970	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
GWQ43_10975	COG0575	Belongs to the CDS family
GWQ43_10980	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
GWQ43_10985	COG0233	cytoplasmic translational termination
GWQ43_10990	COG0528	UMP kinase activity
GWQ43_10995	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
GWQ43_11000	COG0052	Belongs to the universal ribosomal protein uS2 family
GWQ43_11005	COG0024	Methionine aminopeptidase
GWQ43_11010	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
GWQ43_11035	COG1286	toxin biosynthetic process
GWQ43_11045	COG0285	dihydrofolate synthase activity
GWQ43_11050	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GWQ43_11055	COG0508	dehydrogenase complex catalyzes the overall conversion of
GWQ43_11060	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
GWQ43_11075	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
GWQ43_11085	COG1999	signal sequence binding
GWQ43_11095	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GWQ43_11100	COG0640	Transcriptional regulator
GWQ43_11115	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
GWQ43_11120	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
GWQ43_11125	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
GWQ43_11130	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
GWQ43_11135	COG1028	Short-chain dehydrogenase reductase Sdr
GWQ43_11140	COG1028	Short-chain dehydrogenase reductase Sdr
GWQ43_11160	COG0183	Belongs to the thiolase family
GWQ43_11180	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
GWQ43_11190	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GWQ43_11195	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GWQ43_11200	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
GWQ43_11220	COG0183	Belongs to the thiolase family
GWQ43_11225	COG0183	Belongs to the thiolase family
GWQ43_11235	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
GWQ43_11250	COG1982	Orn Lys Arg decarboxylase major
GWQ43_11270	COG0194	GDP metabolic process
GWQ43_11275	COG1758	RNA polymerase activity
GWQ43_11280	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GWQ43_11290	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
GWQ43_11295	COG0739	heme binding
GWQ43_11300	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GWQ43_11305	COG0584	glycerophosphoryl diester phosphodiesterase
GWQ43_11310	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
GWQ43_11315	COG1187	pseudouridine synthase activity
GWQ43_11320	COG3161	chorismate lyase activity
GWQ43_11325	COG2814	Major facilitator Superfamily
GWQ43_11330	COG0656	L-ascorbic acid biosynthetic process
GWQ43_11340	COG0668	transmembrane transport
GWQ43_11345	COG0165	Argininosuccinate lyase
GWQ43_11365	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GWQ43_11375	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GWQ43_11385	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
GWQ43_11390	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
GWQ43_11395	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
GWQ43_11400	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
GWQ43_11405	COG2252	PERMEase
GWQ43_11410	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GWQ43_11430	COG0488	(ABC) transporter
GWQ43_11435	COG1619	proteins homologs of microcin C7 resistance protein MccF
GWQ43_11445	COG1131	(ABC) transporter
GWQ43_11450	COG0842	Transport permease protein
GWQ43_11455	COG0840	transmembrane signaling receptor activity
GWQ43_11465	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
GWQ43_11470	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
GWQ43_11475	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GWQ43_11485	COG2022	thiamine diphosphate biosynthetic process
GWQ43_11505	COG1414	Transcriptional regulator
GWQ43_11515	COG0730	response to heat
GWQ43_11525	COG1666	GTP binding
GWQ43_11530	COG0318	PFAM AMP-dependent synthetase and ligase
GWQ43_11535	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
GWQ43_11540	COG0518	GMP synthase (glutamine-hydrolyzing) activity
GWQ43_11540	COG0519	Catalyzes the synthesis of GMP from XMP
GWQ43_11545	COG2207	Transcriptional regulator
GWQ43_11555	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GWQ43_11560	COG0135	phosphoribosylanthranilate isomerase activity
GWQ43_11565	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
GWQ43_11575	COG0101	tRNA pseudouridine synthase activity
GWQ43_11585	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
GWQ43_11610	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GWQ43_11620	COG4566	intracellular signal transduction
GWQ43_11635	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
GWQ43_11640	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
GWQ43_11650	COG1295	ribonuclease BN
GWQ43_11660	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GWQ43_11690	COG4964	Belongs to the GSP D family
GWQ43_11725	COG3712	iron ion homeostasis
GWQ43_11730	COG1595	DNA-templated transcription, initiation
GWQ43_11740	COG4774	siderophore transport
GWQ43_11745	COG3712	iron ion homeostasis
GWQ43_11770	COG2959	enzyme of heme biosynthesis
GWQ43_11780	COG0181	hydroxymethylbilane synthase activity
GWQ43_11785	COG0861	Integral membrane protein TerC family
GWQ43_11790	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
GWQ43_11795	COG0045	succinate-CoA ligase (ADP-forming) activity
GWQ43_11810	COG0583	DNA-binding transcription factor activity
GWQ43_11815	COG2137	regulation of response to DNA damage stimulus
GWQ43_11820	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
GWQ43_11835	COG0477	Major facilitator Superfamily
GWQ43_11850	COG0318	PFAM AMP-dependent synthetase and ligase
GWQ43_11855	COG1024	Enoyl-CoA hydratase
GWQ43_11860	COG3162	membrane
GWQ43_11875	COG0540	Belongs to the ATCase OTCase family
GWQ43_11890	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GWQ43_11905	COG2070	2-Nitropropane dioxygenase
GWQ43_11915	COG2111	Na H antiporter
GWQ43_11915	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
GWQ43_11920	COG1006	Multisubunit Na H antiporter MnhC subunit
GWQ43_11925	COG0651	ATP synthesis coupled electron transport
GWQ43_11935	COG2212	antiporter activity
GWQ43_11950	COG0477	Major facilitator Superfamily
GWQ43_11975	COG3158	transport of potassium into the cell
GWQ43_11980	COG0642	Histidine kinase
GWQ43_11985	COG0745	RESPONSE REGULATOR receiver
GWQ43_12005	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
GWQ43_12010	COG4208	sulfate ABC transporter
GWQ43_12015	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
GWQ43_12020	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
GWQ43_12035	COG1278	Cold shock
GWQ43_12050	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GWQ43_12050	COG1648	precorrin-2 dehydrogenase activity
GWQ43_12085	COG1648	precorrin-2 dehydrogenase activity
GWQ43_12085	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GWQ43_12095	COG2010	Cytochrome c
GWQ43_12100	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GWQ43_12105	COG0626	cystathionine gamma-synthase activity
GWQ43_12110	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GWQ43_12115	COG0557	exoribonuclease II activity
GWQ43_12140	COG0765	amino acid transport
GWQ43_12145	COG1126	abc transporter atp-binding protein
GWQ43_12160	COG1850	ribulose-bisphosphate carboxylase activity
GWQ43_12180	COG2375	cellular response to nickel ion
GWQ43_12215	COG0583	DNA-binding transcription factor activity
GWQ43_12220	COG3842	ATPase activity
GWQ43_12225	COG1175	transmembrane transport
GWQ43_12230	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GWQ43_12235	COG1840	ABC-type Fe3 transport system, periplasmic component
GWQ43_12270	COG0412	Dienelactone hydrolase
GWQ43_12275	COG3530	Putative quorum-sensing-regulated virulence factor
GWQ43_12280	COG0625	glutathione transferase activity
GWQ43_12285	COG1741	Belongs to the pirin family
GWQ43_12295	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GWQ43_12300	COG2814	Major facilitator Superfamily
GWQ43_12305	COG2807	transmembrane transport
GWQ43_12310	COG2207	Transcriptional regulator
GWQ43_12315	COG3135	benzoate transporter
GWQ43_12340	COG1529	Aldehyde oxidase and xanthine dehydrogenase
GWQ43_12350	COG0402	S-adenosylhomocysteine deaminase activity
GWQ43_12360	COG0745	RESPONSE REGULATOR receiver
GWQ43_12365	COG2205	protein histidine kinase activity
GWQ43_12380	COG0828	Belongs to the bacterial ribosomal protein bS21 family
GWQ43_12385	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
GWQ43_12390	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
GWQ43_12400	COG0330	HflC and HflK could
GWQ43_12405	COG0330	HflC and HflK could
GWQ43_12410	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
GWQ43_12415	COG1923	regulation of RNA biosynthetic process
GWQ43_12425	COG1160	GTP binding
GWQ43_12430	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GWQ43_12435	COG2976	Protein conserved in bacteria
GWQ43_12440	COG0124	histidyl-tRNA synthetase
GWQ43_12455	COG0820	rRNA (adenine-C2-)-methyltransferase activity
GWQ43_12460	COG0105	UTP biosynthetic process
GWQ43_12475	COG0697	spore germination
GWQ43_12480	COG0336	Belongs to the RNA methyltransferase TrmD family
GWQ43_12490	COG0228	four-way junction DNA binding
GWQ43_12495	COG0425	Belongs to the sulfur carrier protein TusA family
GWQ43_12500	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GWQ43_12515	COG2351	hydroxyisourate hydrolase activity
GWQ43_12550	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GWQ43_12575	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
GWQ43_12580	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
GWQ43_12610	COG0601	transmembrane transport
GWQ43_12640	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
GWQ43_12645	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
GWQ43_12650	COG0542	response to heat
GWQ43_12655	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GWQ43_12670	COG0348	domain, Protein
GWQ43_12690	COG3278	Belongs to the heme-copper respiratory oxidase family
GWQ43_12700	COG2217	Heavy metal translocating P-type atpase
GWQ43_12705	COG2224	Isocitrate lyase
GWQ43_12710	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
GWQ43_12710	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
GWQ43_12730	COG1472	Belongs to the glycosyl hydrolase 3 family
GWQ43_12735	COG0736	holo-[acyl-carrier-protein] synthase activity
GWQ43_12745	COG2050	protein possibly involved in aromatic compounds catabolism
GWQ43_12750	COG1024	Enoyl-CoA hydratase
GWQ43_12755	COG1012	belongs to the aldehyde dehydrogenase family
GWQ43_12760	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GWQ43_12765	COG2151	metal-sulfur cluster biosynthetic enzyme
GWQ43_12770	COG3396	Phenylacetate-CoA oxygenase
GWQ43_12775	COG3460	Phenylacetate-CoA oxygenase
GWQ43_12780	COG3396	Phenylacetate-CoA oxygenase
GWQ43_12785	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
GWQ43_12790	COG0501	Belongs to the peptidase M48B family
GWQ43_12795	COG1162	GTPase activity
GWQ43_12805	COG0335	large ribosomal subunit rRNA binding
GWQ43_12825	COG0450	alkyl hydroperoxide reductase
GWQ43_12830	COG1960	acyl-CoA dehydrogenase activity
GWQ43_12850	COG2951	lytic endotransglycosylase activity
GWQ43_12860	COG1555	photosystem II stabilization
GWQ43_12860	COG1596	polysaccharide export
GWQ43_12865	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GWQ43_12870	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
GWQ43_12875	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
GWQ43_12895	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
GWQ43_12900	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
GWQ43_12905	COG0287	Prephenate dehydrogenase
GWQ43_12915	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
GWQ43_12930	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GWQ43_12950	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
GWQ43_12970	COG0753	catalase activity
GWQ43_12980	COG4335	DNA alkylation repair
GWQ43_12990	COG0436	Aminotransferase
GWQ43_13000	COG0251	oxidation-reduction process
GWQ43_13005	COG1309	transcriptional regulator
GWQ43_13015	COG0488	(ABC) transporter
GWQ43_13065	COG0625	glutathione transferase activity
GWQ43_13105	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
GWQ43_13110	COG0732	type I restriction modification DNA specificity domain
GWQ43_13115	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
GWQ43_13125	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
GWQ43_13130	COG1280	lysine exporter protein (LysE YggA)
GWQ43_13150	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GWQ43_13160	COG5002	protein histidine kinase activity
GWQ43_13165	COG2046	Belongs to the sulfate adenylyltransferase family
GWQ43_13170	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
GWQ43_13185	COG0840	transmembrane signaling receptor activity
GWQ43_13190	COG2119	membrane
GWQ43_13205	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
GWQ43_13210	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GWQ43_13225	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
GWQ43_13230	COG2321	neutral zinc metallopeptidase
GWQ43_13245	COG2175	clavaminate synthase activity
GWQ43_13250	COG1846	Transcriptional regulator
GWQ43_13255	COG0347	Belongs to the P(II) protein family
GWQ43_13260	COG0004	ammonium transporteR
GWQ43_13265	COG3909	cytochrome
GWQ43_13275	COG0625	glutathione transferase activity
GWQ43_13285	COG0657	acetylesterase activity
GWQ43_13290	COG0730	response to heat
GWQ43_13295	COG0482	sulfurtransferase activity
GWQ43_13300	COG0277	FAD linked oxidase domain protein
GWQ43_13305	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GWQ43_13310	COG2879	small protein
GWQ43_13315	COG1966	Carbon starvation protein
GWQ43_13320	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GWQ43_13325	COG0765	amino acid transport
GWQ43_13330	COG0765	amino acid transport
GWQ43_13335	COG1126	abc transporter atp-binding protein
GWQ43_13340	COG0028	Belongs to the TPP enzyme family
GWQ43_13345	COG1012	belongs to the aldehyde dehydrogenase family
GWQ43_13350	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
GWQ43_13355	COG1028	Short-chain dehydrogenase reductase Sdr
GWQ43_13365	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GWQ43_13370	COG1116	anion transmembrane transporter activity
GWQ43_13385	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
GWQ43_13400	COG5285	phytanoyl-CoA dioxygenase
GWQ43_13405	COG0662	Cupin 2, conserved barrel domain protein
GWQ43_13415	COG0456	acetyltransferase
GWQ43_13420	COG1846	Transcriptional regulator
GWQ43_13430	COG0312	modulator of DNA gyrase
GWQ43_13445	COG0308	aminopeptidase N
GWQ43_13450	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
GWQ43_13465	COG0473	3-isopropylmalate dehydrogenase activity
GWQ43_13475	COG0433	COG0433 Predicted ATPase
GWQ43_13480	COG0217	transcriptional regulatory protein
GWQ43_13485	COG0151	Belongs to the GarS family
GWQ43_13495	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
GWQ43_13500	COG0799	negative regulation of ribosome biogenesis
GWQ43_13505	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
GWQ43_13510	COG0424	maF-like protein
GWQ43_13530	COG0023	Translation Initiation Factor
GWQ43_13540	COG2084	Dehydrogenase
GWQ43_13545	COG0625	glutathione transferase activity
GWQ43_13550	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
GWQ43_13555	COG1047	Peptidyl-prolyl cis-trans
GWQ43_13560	COG2003	Belongs to the UPF0758 family
GWQ43_13565	COG1737	Transcriptional regulator
GWQ43_13570	COG0477	Major facilitator Superfamily
GWQ43_13580	COG2271	Major facilitator Superfamily
GWQ43_13595	COG0534	Mate efflux family protein
GWQ43_13600	COG4175	Glycine betaine
GWQ43_13605	COG4176	ABC-type proline glycine betaine transport system permease component
GWQ43_13615	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
GWQ43_13620	COG2814	Major facilitator Superfamily
GWQ43_13625	COG0227	Belongs to the bacterial ribosomal protein bL28 family
GWQ43_13630	COG0267	Belongs to the bacterial ribosomal protein bL33 family
GWQ43_13635	COG0495	leucyl-tRNA aminoacylation
GWQ43_13645	COG1466	dna polymerase III delta subunit
GWQ43_13650	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
GWQ43_13670	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
GWQ43_13680	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
GWQ43_13685	COG0148	phosphopyruvate hydratase activity
GWQ43_13695	COG2814	Major facilitator Superfamily
GWQ43_13710	COG2877	3-deoxy-8-phosphooctulonate synthase activity
GWQ43_13720	COG0504	CTP synthase activity
GWQ43_13750	COG0697	spore germination
GWQ43_13755	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GWQ43_13765	COG0791	NLP P60 protein
GWQ43_13775	COG0583	DNA-binding transcription factor activity
GWQ43_13785	COG0583	DNA-binding transcription factor activity
GWQ43_13795	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
GWQ43_13810	COG1045	serine acetyltransferase
GWQ43_13825	COG1381	Involved in DNA repair and RecF pathway recombination
GWQ43_13830	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
GWQ43_13835	COG0571	ribonuclease III activity
GWQ43_13850	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GWQ43_13870	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GWQ43_13875	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GWQ43_13880	COG1028	Short-chain dehydrogenase reductase Sdr
GWQ43_13885	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
GWQ43_13890	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GWQ43_13900	COG0333	Belongs to the bacterial ribosomal protein bL32 family
GWQ43_13905	COG1399	metal-binding, possibly nucleic acid-binding protein
GWQ43_13910	COG0424	maF-like protein
GWQ43_13920	COG3023	N-Acetylmuramoyl-L-alanine amidase
GWQ43_13925	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
GWQ43_13930	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
GWQ43_13935	COG0546	phosphoglycolate phosphatase activity
GWQ43_13940	COG0564	pseudouridine synthase activity
GWQ43_13945	COG1530	ribonuclease E activity
GWQ43_13950	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
GWQ43_13955	COG0159	tryptophan synthase activity
GWQ43_13960	COG0133	tryptophan synthase activity
GWQ43_13965	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GWQ43_13975	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
GWQ43_13980	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
GWQ43_13990	COG2878	Part of a membrane complex involved in electron transport
GWQ43_13995	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
GWQ43_14000	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
GWQ43_14005	COG3047	cAMP biosynthetic process
GWQ43_14030	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GWQ43_14035	COG2917	probably involved in intracellular septation
GWQ43_14045	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GWQ43_14050	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
GWQ43_14060	COG1196	nuclear chromosome segregation
GWQ43_14070	COG1573	uracil-dna glycosylase
GWQ43_14075	COG1214	PFAM Peptidase M22, glycoprotease
GWQ43_14080	COG0745	RESPONSE REGULATOR receiver
GWQ43_14085	COG2205	protein histidine kinase activity
GWQ43_14090	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
GWQ43_14095	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
GWQ43_14100	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
GWQ43_14105	COG0560	Phosphoserine phosphatase
GWQ43_14120	COG1007	ATP synthesis coupled electron transport
GWQ43_14135	COG0713	ATP synthesis coupled electron transport
GWQ43_14145	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GWQ43_14150	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
GWQ43_14155	COG1034	ATP synthesis coupled electron transport
GWQ43_14170	COG0649	NAD binding
GWQ43_14175	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GWQ43_14180	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GWQ43_14185	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GWQ43_14190	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
GWQ43_14205	COG0149	triose-phosphate isomerase activity
GWQ43_14210	COG0604	alcohol dehydrogenase
GWQ43_14230	COG1185	polyribonucleotide nucleotidyltransferase activity
GWQ43_14235	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
GWQ43_14240	COG1183	phosphatidylcholine synthase activity
GWQ43_14245	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
GWQ43_14250	COG0440	acetolactate synthase activity
GWQ43_14255	COG0028	Belongs to the TPP enzyme family
GWQ43_14260	COG1289	transmembrane transporter activity
GWQ43_14265	COG3022	response to hydroperoxide
GWQ43_14270	COG1028	Short-chain dehydrogenase reductase Sdr
GWQ43_14290	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
GWQ43_14295	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
GWQ43_14300	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
GWQ43_14305	COG1674	ftsk spoiiie
GWQ43_14310	COG0492	ferredoxin-NADP+ reductase activity
GWQ43_14330	COG0477	Major facilitator Superfamily
GWQ43_14350	COG2272	Belongs to the type-B carboxylesterase lipase family
GWQ43_14355	COG1960	acyl-CoA dehydrogenase activity
GWQ43_14370	COG0438	transferase activity, transferring glycosyl groups
GWQ43_14395	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GWQ43_14415	COG2204	response regulator
GWQ43_14455	COG4964	Belongs to the GSP D family
GWQ43_14515	COG0612	Peptidase, M16
GWQ43_14520	COG0484	heat shock protein binding
GWQ43_14525	COG0443	Heat shock 70 kDa protein
GWQ43_14530	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
GWQ43_14535	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
GWQ43_14540	COG1420	regulation of RNA biosynthetic process
GWQ43_14550	COG0497	DNA recombination
GWQ43_14555	COG0735	belongs to the Fur family
GWQ43_14560	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GWQ43_14565	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
GWQ43_14590	COG0477	Major facilitator Superfamily
GWQ43_14595	COG1301	dicarboxylic acid transport
GWQ43_14605	COG0812	UDP-N-acetylmuramate dehydrogenase activity
GWQ43_14640	COG1538	Outer membrane efflux protein
GWQ43_14700	COG2814	Major facilitator Superfamily
GWQ43_14710	COG3383	formate dehydrogenase (NAD+) activity
GWQ43_14710	COG0243	molybdopterin cofactor binding
GWQ43_14715	COG0437	4 iron, 4 sulfur cluster binding
GWQ43_14720	COG2864	formate dehydrogenase
GWQ43_14725	COG3058	Necessary for formate dehydrogenase activity
GWQ43_14730	COG2819	hydrolase of the alpha beta superfamily
GWQ43_14750	COG1454	alcohol dehydrogenase
GWQ43_14785	COG1414	Transcriptional regulator
GWQ43_14790	COG0513	Belongs to the DEAD box helicase family
GWQ43_14795	COG3657	addiction module killer protein
GWQ43_14800	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GWQ43_14805	COG0583	DNA-binding transcription factor activity
GWQ43_14810	COG4638	Rieske (2fe-2S)
GWQ43_14815	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
GWQ43_14830	COG0446	pyridine nucleotide-disulphide oxidoreductase
GWQ43_14850	COG4569	acetaldehyde dehydrogenase (acetylating) activity
GWQ43_14855	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GWQ43_14860	COG2814	Major facilitator Superfamily
GWQ43_14880	COG3121	Chaperone
GWQ43_14890	COG0784	Response regulator, receiver
GWQ43_14890	COG2205	protein histidine kinase activity
GWQ43_14895	COG0784	Response regulator, receiver
GWQ43_14895	COG2205	protein histidine kinase activity
GWQ43_14900	COG2197	response regulator
GWQ43_14905	COG5001	Diguanylate cyclase
GWQ43_14905	COG4251	negative regulation of phosphorylation
GWQ43_14905	COG3706	GGDEF domain
GWQ43_14905	COG2203	Gaf domain
GWQ43_14915	COG0154	amidase activity
GWQ43_14920	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GWQ43_14925	COG2814	Major facilitator Superfamily
GWQ43_14960	COG1028	Short-chain dehydrogenase reductase Sdr
GWQ43_14970	COG0842	Transport permease protein
GWQ43_14975	COG0842	Transport permease protein
GWQ43_14975	COG1129	ABC transporter
GWQ43_14980	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GWQ43_14990	COG3243	poly(R)-hydroxyalkanoic acid synthase
GWQ43_15000	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
GWQ43_15005	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
GWQ43_15010	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GWQ43_15025	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GWQ43_15040	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
GWQ43_15045	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
GWQ43_15055	COG0789	Transcriptional regulator
GWQ43_15065	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GWQ43_15110	COG3278	Belongs to the heme-copper respiratory oxidase family
GWQ43_15115	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GWQ43_15135	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
GWQ43_15180	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
GWQ43_15245	COG0516	GMP reductase activity
GWQ43_15245	COG0517	IMP dehydrogenase activity
GWQ43_15260	COG1027	Aspartate ammonia-lyase
GWQ43_15265	COG1846	Transcriptional regulator
GWQ43_15280	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
GWQ43_15285	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
GWQ43_15300	COG1414	Transcriptional regulator
GWQ43_15320	COG0513	Belongs to the DEAD box helicase family
GWQ43_15340	COG0429	hydrolase of the alpha beta-hydrolase fold
GWQ43_15365	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GWQ43_15375	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
GWQ43_15385	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
GWQ43_15390	COG0632	four-way junction helicase activity
GWQ43_15400	COG2255	four-way junction helicase activity
GWQ43_15410	COG0418	dihydroorotase activity
GWQ43_15420	COG0415	Belongs to the DNA photolyase family
GWQ43_15475	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GWQ43_15480	COG4654	Cytochrome c, class I
GWQ43_15520	COG1177	transmembrane transport
GWQ43_15525	COG3842	ATPase activity
GWQ43_15530	COG1840	ABC-type Fe3 transport system, periplasmic component
GWQ43_15535	COG2084	Dehydrogenase
GWQ43_15550	COG0494	nUDIX hydrolase
GWQ43_15555	COG0442	prolyl-tRNA aminoacylation
GWQ43_15560	COG0824	Thioesterase
GWQ43_15565	COG0811	peptide transport
GWQ43_15580	COG0823	Involved in the tonB-independent uptake of proteins
GWQ43_15595	COG0596	Alpha beta hydrolase
GWQ43_15630	COG1129	ABC transporter
GWQ43_15650	COG0427	acetyl-CoA hydrolase
GWQ43_15655	COG0583	DNA-binding transcription factor activity
GWQ43_15660	COG3634	alkyl hydroperoxide reductase activity
GWQ43_15675	COG0697	spore germination
GWQ43_15680	COG0175	sulfate reduction
GWQ43_15695	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
GWQ43_15710	COG0583	DNA-binding transcription factor activity
GWQ43_15715	COG1741	Belongs to the pirin family
GWQ43_15720	COG3706	GGDEF domain
GWQ43_15725	COG0154	amidase activity
GWQ43_15735	COG3712	iron ion homeostasis
GWQ43_15740	COG1595	DNA-templated transcription, initiation
GWQ43_15750	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
GWQ43_15760	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
GWQ43_15765	COG0284	orotidine-5'-phosphate decarboxylase activity
GWQ43_15780	COG1414	Transcriptional regulator
GWQ43_15790	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
GWQ43_15800	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GWQ43_15805	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
GWQ43_15830	COG0742	ribosomal rna small subunit methyltransferase
GWQ43_15835	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
GWQ43_15840	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
GWQ43_15870	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
GWQ43_15885	COG1335	isochorismatase
GWQ43_15890	COG2309	aminopeptidase activity
GWQ43_15895	COG0596	Alpha beta hydrolase
GWQ43_15900	COG1529	Aldehyde oxidase and xanthine dehydrogenase
GWQ43_15900	COG2010	Cytochrome c
GWQ43_15905	COG2080	2 iron, 2 sulfur cluster binding
GWQ43_15910	COG1529	Aldehyde oxidase and xanthine dehydrogenase
GWQ43_15910	COG2010	Cytochrome c
GWQ43_15920	COG0410	ABC transporter
GWQ43_15925	COG0411	ABC transporter
GWQ43_15950	COG3706	GGDEF domain
GWQ43_15965	COG3181	Tripartite tricarboxylate transporter family receptor
GWQ43_15980	COG1234	tRNA 3'-trailer cleavage
GWQ43_15985	COG2188	Transcriptional regulator
GWQ43_15995	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GWQ43_16005	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
GWQ43_16005	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
GWQ43_16010	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
GWQ43_16010	COG3608	succinylglutamate desuccinylase aspartoacylase
GWQ43_16015	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
GWQ43_16025	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GWQ43_16055	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
GWQ43_16080	COG1335	isochorismatase
GWQ43_16085	COG2309	aminopeptidase activity
GWQ43_16090	COG0596	Alpha beta hydrolase
GWQ43_16105	COG1120	ATPase activity
GWQ43_16120	COG4206	TonB-dependent receptor
GWQ43_16125	COG2031	fatty acid transporter
GWQ43_16130	COG0583	DNA-binding transcription factor activity
GWQ43_16135	COG0402	S-adenosylhomocysteine deaminase activity
GWQ43_16140	COG3181	Tripartite tricarboxylate transporter family receptor
GWQ43_16155	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GWQ43_16160	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GWQ43_16165	COG0328	RNA-DNA hybrid ribonuclease activity
GWQ43_16170	COG2226	methyltransferase
GWQ43_16175	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GWQ43_16180	COG1388	LysM domain
GWQ43_16180	COG0741	lytic transglycosylase activity
GWQ43_16190	COG2204	response regulator
GWQ43_16195	COG4191	Histidine kinase
GWQ43_16200	COG1301	dicarboxylic acid transport
GWQ43_16235	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
GWQ43_16240	COG2204	response regulator
GWQ43_16255	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
GWQ43_16270	COG1028	Short-chain dehydrogenase reductase Sdr
GWQ43_16275	COG1877	trehalose-phosphatase activity
GWQ43_16310	COG0604	alcohol dehydrogenase
GWQ43_16320	COG1024	Enoyl-CoA hydratase
GWQ43_16340	COG1902	pentaerythritol trinitrate reductase activity
GWQ43_16365	COG0583	DNA-binding transcription factor activity
GWQ43_16370	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GWQ43_16375	COG1454	alcohol dehydrogenase
GWQ43_16395	COG0583	DNA-binding transcription factor activity
GWQ43_16435	COG1393	Belongs to the ArsC family
GWQ43_16440	COG0431	NADPH-dependent FMN reductase
GWQ43_16445	COG0745	RESPONSE REGULATOR receiver
GWQ43_16450	COG0642	Histidine kinase
GWQ43_16465	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GWQ43_16465	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GWQ43_16470	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
GWQ43_16475	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GWQ43_16480	COG1881	PFAM PEBP family protein
GWQ43_16485	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GWQ43_16490	COG0739	heme binding
GWQ43_16495	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
GWQ43_16500	COG0316	Belongs to the HesB IscA family
GWQ43_16510	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
GWQ43_16515	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GWQ43_16520	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
GWQ43_16525	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
GWQ43_16530	COG0312	modulator of DNA gyrase
GWQ43_16535	COG3028	Belongs to the UPF0307 family
GWQ43_16565	COG4566	intracellular signal transduction
GWQ43_16570	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GWQ43_16575	COG4681	YaeQ
GWQ43_16600	COG0762	integral membrane protein
GWQ43_16605	COG2169	Transcriptional regulator
GWQ43_16605	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
GWQ43_16615	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GWQ43_16630	COG0439	Biotin carboxylase
GWQ43_16635	COG0511	ligase activity, forming carbon-carbon bonds
GWQ43_16640	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
GWQ43_16645	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GWQ43_16650	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GWQ43_16655	COG3150	esterase
GWQ43_16670	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
GWQ43_16675	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GWQ43_16685	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
GWQ43_16700	COG1678	Uncharacterized ACR, COG1678
GWQ43_16715	COG0352	thiamine-phosphate diphosphorylase activity
GWQ43_16720	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
GWQ43_16735	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
GWQ43_16745	COG3237	CsbD-like
GWQ43_16750	COG0261	This protein binds to 23S rRNA in the presence of protein L20
GWQ43_16755	COG0211	Belongs to the bacterial ribosomal protein bL27 family
GWQ43_16760	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
GWQ43_16765	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
GWQ43_16790	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
GWQ43_16805	COG1126	abc transporter atp-binding protein
GWQ43_16810	COG0765	amino acid transport
GWQ43_16815	COG4597	amino acid ABC transporter
GWQ43_16820	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GWQ43_16825	COG2884	Cell division ATP-binding protein ftsE
GWQ43_16830	COG2177	Part of the ABC transporter FtsEX involved in
GWQ43_16840	COG0772	Belongs to the SEDS family
GWQ43_16845	COG0768	penicillin binding
GWQ43_16855	COG1792	Involved in formation and maintenance of cell shape
GWQ43_16860	COG1077	Cell shape determining protein MreB Mrl
GWQ43_16865	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GWQ43_16870	COG0154	amidase activity
GWQ43_16875	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GWQ43_16880	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
GWQ43_16885	COG0583	DNA-binding transcription factor activity
GWQ43_16890	COG2259	Doxx family
GWQ43_16895	COG3384	dioxygenase
GWQ43_16905	COG3245	cytochrome
GWQ43_16920	COG3604	Transcriptional regulator
GWQ43_16935	COG0786	glutamate:sodium symporter activity
GWQ43_16940	COG0142	geranyltranstransferase activity
GWQ43_16950	COG0494	nUDIX hydrolase
GWQ43_16955	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
GWQ43_16980	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
GWQ43_16985	COG0237	dephospho-CoA kinase activity
GWQ43_17000	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
GWQ43_17005	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
GWQ43_17015	COG0477	Major facilitator Superfamily
GWQ43_17030	COG4206	TonB-dependent receptor
GWQ43_17035	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GWQ43_17050	COG1595	DNA-templated transcription, initiation
GWQ43_17060	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
GWQ43_17080	COG0598	Magnesium transport protein CorA
GWQ43_17095	COG2022	thiamine diphosphate biosynthetic process
GWQ43_17100	COG0351	phosphomethylpyrimidine kinase
GWQ43_17105	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
GWQ43_17110	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
GWQ43_17115	COG1538	Outer membrane efflux protein
GWQ43_17120	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
GWQ43_17130	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
GWQ43_17145	COG2226	methyltransferase
GWQ43_17150	COG0745	RESPONSE REGULATOR receiver
GWQ43_17165	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
GWQ43_17170	COG1984	allophanate hydrolase subunit 2
GWQ43_17175	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
GWQ43_17180	COG1238	metal cluster binding
GWQ43_17205	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
GWQ43_17210	COG4988	ABC transporter
GWQ43_17220	COG1294	oxidase, subunit
GWQ43_17225	COG1271	oxidase subunit
GWQ43_17240	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
GWQ43_17255	COG1137	ATPase activity
GWQ43_17265	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GWQ43_17270	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
GWQ43_17275	COG1660	Displays ATPase and GTPase activities
GWQ43_17285	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
GWQ43_17290	COG0792	nuclease activity
GWQ43_17295	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
GWQ43_17310	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
GWQ43_17330	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
GWQ43_17335	COG0793	Belongs to the peptidase S41A family
GWQ43_17345	COG0588	phosphoglycerate mutase activity
GWQ43_17350	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GWQ43_17360	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
GWQ43_17365	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
GWQ43_17370	COG3181	Tripartite tricarboxylate transporter family receptor
GWQ43_17375	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
GWQ43_17380	COG1040	competence protein
GWQ43_17385	COG2226	methyltransferase
GWQ43_17390	COG4771	TonB-dependent receptor
GWQ43_17395	COG0745	RESPONSE REGULATOR receiver
GWQ43_17410	COG2204	response regulator
GWQ43_17430	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GWQ43_17445	COG3473	Maleate cis-trans isomerase
GWQ43_17460	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
GWQ43_17490	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
GWQ43_17490	COG0662	Cupin 2, conserved barrel domain protein
GWQ43_17495	COG1215	transferase activity, transferring glycosyl groups
GWQ43_17505	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GWQ43_17525	COG1088	dTDP-glucose 4,6-dehydratase activity
GWQ43_17530	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
GWQ43_17545	COG0355	proton-transporting ATP synthase activity, rotational mechanism
GWQ43_17555	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
GWQ43_17560	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
GWQ43_17565	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GWQ43_17580	COG0356	it plays a direct role in the translocation of protons across the membrane
GWQ43_17590	COG1024	Enoyl-CoA hydratase
GWQ43_17605	COG0037	tRNA processing
GWQ43_17610	COG0163	prenyltransferase activity
GWQ43_17615	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
GWQ43_17620	COG2890	protein-(glutamine-N5) methyltransferase activity
GWQ43_17670	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GWQ43_17700	COG0811	peptide transport
GWQ43_17715	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
GWQ43_17720	COG2264	protein methyltransferase activity
GWQ43_17725	COG4773	Receptor
GWQ43_17745	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GWQ43_17770	COG3180	Ammonia monooxygenase
GWQ43_17790	COG5002	protein histidine kinase activity
GWQ43_17805	COG0477	Major facilitator Superfamily
GWQ43_17810	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GWQ43_17830	COG1116	anion transmembrane transporter activity
GWQ43_17860	COG0437	4 iron, 4 sulfur cluster binding
GWQ43_17865	COG2864	formate dehydrogenase
GWQ43_17875	COG1921	L-seryl-tRNASec selenium transferase activity
GWQ43_17880	COG3276	selenocysteine insertion sequence binding
GWQ43_17890	COG1476	TRANSCRIPTIONal
GWQ43_17895	COG0235	Class ii aldolase
GWQ43_17905	COG3181	Tripartite tricarboxylate transporter family receptor
GWQ43_17915	COG4771	TonB-dependent receptor
GWQ43_17930	COG0709	Synthesizes selenophosphate from selenide and ATP
GWQ43_17945	COG0583	DNA-binding transcription factor activity
GWQ43_17950	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
GWQ43_17955	COG0348	domain, Protein
GWQ43_17955	COG3901	Regulator of nitric oxide reductase transcription
GWQ43_17960	COG4263	nitrous-oxide reductase activity
GWQ43_17975	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
GWQ43_17990	COG0166	Belongs to the GPI family
GWQ43_18010	COG1215	transferase activity, transferring glycosyl groups
GWQ43_18050	COG0438	transferase activity, transferring glycosyl groups
GWQ43_18060	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
GWQ43_18095	COG0156	8-amino-7-oxononanoate synthase activity
GWQ43_18100	COG0604	alcohol dehydrogenase
GWQ43_18100	COG1028	Short-chain dehydrogenase reductase Sdr
GWQ43_18100	COG3321	synthase
GWQ43_18105	COG2233	PERMEase
GWQ43_18110	COG0697	spore germination
GWQ43_18115	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GWQ43_18120	COG0697	spore germination
GWQ43_18145	COG2885	chlorophyll binding
GWQ43_18230	COG3501	Rhs element vgr protein
GWQ43_18240	COG0183	Belongs to the thiolase family
GWQ43_18245	COG1024	Enoyl-CoA hydratase
GWQ43_18245	COG1250	3-hydroxyacyl-CoA dehydrogenase
GWQ43_18260	COG1127	ABC transporter
GWQ43_18265	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
GWQ43_18270	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
GWQ43_18285	COG1131	(ABC) transporter
GWQ43_18290	COG0842	Transport permease protein
GWQ43_18300	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
GWQ43_18310	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
GWQ43_18315	COG0131	Imidazoleglycerol-phosphate dehydratase
GWQ43_18325	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
GWQ43_18330	COG0107	imidazoleglycerol-phosphate synthase activity
GWQ43_18340	COG0140	phosphoribosyl-ATP diphosphatase activity
GWQ43_18345	COG0537	adenosine 5'-monophosphoramidase activity
GWQ43_18350	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GWQ43_18355	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GWQ43_18365	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GWQ43_18375	COG1970	mechanosensitive ion channel activity
GWQ43_18380	COG0723	plastoquinol--plastocyanin reductase activity
GWQ43_18385	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
GWQ43_18390	COG2857	Cytochrome c1
GWQ43_18395	COG0625	glutathione transferase activity
GWQ43_18400	COG2969	positive regulation of protein catabolic process
GWQ43_18405	COG4208	sulfate ABC transporter
GWQ43_18410	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
GWQ43_18415	COG4150	thiosulfate binding
GWQ43_18435	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GWQ43_18455	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
GWQ43_18460	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GWQ43_18475	COG0129	dihydroxy-acid dehydratase activity
GWQ43_18480	COG1802	Transcriptional regulator
GWQ43_18485	COG1522	sequence-specific DNA binding
GWQ43_18495	COG3483	tryptophan 2,3-dioxygenase activity
GWQ43_18515	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
GWQ43_18520	COG0656	L-ascorbic acid biosynthetic process
GWQ43_18530	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
GWQ43_18540	COG2226	methyltransferase
GWQ43_18550	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GWQ43_18565	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
GWQ43_18570	COG0583	DNA-binding transcription factor activity
GWQ43_18575	COG0477	Major facilitator Superfamily
GWQ43_18580	COG1028	Short-chain dehydrogenase reductase Sdr
GWQ43_18590	COG1335	isochorismatase
GWQ43_18595	COG1335	isochorismatase
GWQ43_18615	COG2823	Periplasmic or secreted lipoprotein
GWQ43_18625	COG3284	Transcriptional regulator
GWQ43_18640	COG4774	siderophore transport
GWQ43_18670	COG1595	DNA-templated transcription, initiation
GWQ43_18680	COG1522	sequence-specific DNA binding
GWQ43_18690	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
GWQ43_18710	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
GWQ43_18745	COG0109	protoheme IX farnesyltransferase activity
GWQ43_18765	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GWQ43_18785	COG3568	Endonuclease Exonuclease Phosphatase
GWQ43_18790	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
GWQ43_18815	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GWQ43_18825	COG1228	amidohydrolase
GWQ43_18845	COG2986	histidine ammonia-lyase
GWQ43_18850	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
GWQ43_18880	COG2814	Major facilitator Superfamily
GWQ43_18890	COG0789	Transcriptional regulator
GWQ43_18910	COG0625	glutathione transferase activity
GWQ43_18940	COG2365	Tyrosine phosphatase family
GWQ43_18945	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
GWQ43_18965	COG2423	ornithine cyclodeaminase activity
GWQ43_19015	COG3069	C4-dicarboxylate transmembrane transporter activity
GWQ43_19025	COG1802	Transcriptional regulator
GWQ43_19035	COG2814	Major facilitator Superfamily
GWQ43_19050	COG2814	Major facilitator Superfamily
GWQ43_19055	COG0251	oxidation-reduction process
GWQ43_19060	COG3181	Tripartite tricarboxylate transporter family receptor
GWQ43_19065	COG0179	Fumarylacetoacetate (FAA) hydrolase
GWQ43_19070	COG2186	Transcriptional regulator
GWQ43_19075	COG1595	DNA-templated transcription, initiation
GWQ43_19080	COG3712	iron ion homeostasis
GWQ43_19095	COG2814	Major facilitator Superfamily
GWQ43_19105	COG0232	Belongs to the dGTPase family. Type 2 subfamily
GWQ43_19110	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
GWQ43_19115	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
GWQ43_19135	COG5002	protein histidine kinase activity
GWQ43_19135	COG5001	Diguanylate cyclase
GWQ43_19140	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GWQ43_19145	COG1333	cytochrome c biogenesis protein
GWQ43_19155	COG0218	Necessary for normal cell division and for the maintenance of normal septation
GWQ43_19160	COG0113	porphobilinogen synthase activity
GWQ43_19165	COG4232	protein-disulfide reductase activity
GWQ43_19185	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GWQ43_19190	COG0203	ribosomal protein L17
GWQ43_19195	COG0202	RNA polymerase activity
GWQ43_19200	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
GWQ43_19205	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
GWQ43_19210	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
GWQ43_19215	COG0257	Belongs to the bacterial ribosomal protein bL36 family
GWQ43_19225	COG0201	protein transport
GWQ43_19230	COG0200	Binds to the 23S rRNA
GWQ43_19235	COG1841	ribosomal large subunit assembly
GWQ43_19240	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
GWQ43_19245	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
GWQ43_19250	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
GWQ43_19255	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
GWQ43_19260	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
GWQ43_19265	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
GWQ43_19270	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
GWQ43_19275	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
GWQ43_19315	COG1538	Outer membrane efflux protein
GWQ43_19330	COG1960	acyl-CoA dehydrogenase activity
GWQ43_19335	COG0183	Belongs to the thiolase family
GWQ43_19345	COG2067	long-chain fatty acid transport protein
GWQ43_19360	COG0318	PFAM AMP-dependent synthetase and ligase
GWQ43_19365	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
GWQ43_19370	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GWQ43_19375	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GWQ43_19375	COG1648	precorrin-2 dehydrogenase activity
GWQ43_19390	COG1116	anion transmembrane transporter activity
GWQ43_19410	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
GWQ43_19415	COG0255	Belongs to the universal ribosomal protein uL29 family
GWQ43_19420	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
GWQ43_19425	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
GWQ43_19430	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
GWQ43_19435	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
GWQ43_19440	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
GWQ43_19445	COG0089	rRNA binding
GWQ43_19450	COG0088	Forms part of the polypeptide exit tunnel
GWQ43_19455	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
GWQ43_19460	COG4175	Glycine betaine
GWQ43_19465	COG4176	ABC-type proline glycine betaine transport system permease component
GWQ43_19470	COG0051	transcription antitermination factor activity, RNA binding
GWQ43_19475	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
GWQ43_19480	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GWQ43_19485	COG0049	tRNA binding
GWQ43_19490	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
GWQ43_19520	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
GWQ43_19525	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
GWQ43_19530	COG0085	RNA polymerase activity
GWQ43_19535	COG0222	ribosome binding
GWQ43_19540	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
GWQ43_19545	COG0081	regulation of translation
GWQ43_19570	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
GWQ43_19590	COG1475	DNA binding
GWQ43_19595	COG1192	Involved in chromosome partitioning
GWQ43_19600	COG0357	Ribosomal RNA small subunit methyltransferase G
GWQ43_19605	COG0445	tRNA wobble uridine modification
GWQ43_19610	COG0436	Aminotransferase
GWQ43_19620	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
GWQ43_19625	COG3706	GGDEF domain
GWQ43_19630	COG0688	phosphatidylethanolamine metabolic process
GWQ43_19640	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
GWQ43_19685	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
GWQ43_19720	COG0559	Belongs to the binding-protein-dependent transport system permease family
GWQ43_19740	COG0596	Alpha beta hydrolase
GWQ43_19745	COG2309	aminopeptidase activity
GWQ43_19750	COG1335	isochorismatase
GWQ43_19775	COG0753	catalase activity
GWQ43_19780	COG0706	membrane insertase activity
GWQ43_19785	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
GWQ43_19790	COG0594	ribonuclease P activity
GWQ43_19795	COG0230	Belongs to the bacterial ribosomal protein bL34 family
GWQ43_19920	COG0616	signal peptide processing
GWQ43_20105	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
GWQ43_20170	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GWQ43_20175	COG0798	PFAM Bile acid sodium symporter
GWQ43_20200	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GWQ43_20215	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GWQ43_20265	COG1192	Involved in chromosome partitioning
GWQ43_20310	COG3300	MHYT domain
GWQ43_20310	COG5001	Diguanylate cyclase
GWQ43_20360	COG3173	Aminoglycoside phosphotransferase
GWQ43_20370	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
GWQ43_20405	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs