locus-tag	class	description
M2J83_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
M2J83_00010	COG0592	DNA-directed DNA polymerase activity
M2J83_00020	COG1187	pseudouridine synthase activity
M2J83_00035	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
M2J83_00065	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
M2J83_00070	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
M2J83_00085	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M2J83_00105	COG2070	2-Nitropropane dioxygenase
M2J83_00115	COG1960	acyl-CoA dehydrogenase activity
M2J83_00125	COG1804	L-carnitine dehydratase bile acid-inducible protein F
M2J83_00135	COG1804	L-carnitine dehydratase bile acid-inducible protein F
M2J83_00145	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
M2J83_00165	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
M2J83_00170	COG0583	DNA-binding transcription factor activity
M2J83_00180	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
M2J83_00190	COG0559	Belongs to the binding-protein-dependent transport system permease family
M2J83_00205	COG0318	PFAM AMP-dependent synthetase and ligase
M2J83_00215	COG0508	dehydrogenase complex catalyzes the overall conversion of
M2J83_00215	COG0596	Alpha beta hydrolase
M2J83_00220	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M2J83_00235	COG3181	Tripartite tricarboxylate transporter family receptor
M2J83_00245	COG0697	spore germination
M2J83_00250	COG0583	DNA-binding transcription factor activity
M2J83_00260	COG3842	ATPase activity
M2J83_00270	COG0436	Aminotransferase
M2J83_00280	COG0523	cobalamin synthesis protein
M2J83_00335	COG1846	Transcriptional regulator
M2J83_00355	COG0179	Fumarylacetoacetate (FAA) hydrolase
M2J83_00360	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
M2J83_00365	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
M2J83_00375	COG4638	Rieske (2fe-2S)
M2J83_00430	COG1028	Short-chain dehydrogenase reductase Sdr
M2J83_00450	COG2207	Transcriptional regulator
M2J83_00485	COG1595	DNA-templated transcription, initiation
M2J83_00490	COG4608	Belongs to the ABC transporter superfamily
M2J83_00495	COG0444	Belongs to the ABC transporter superfamily
M2J83_00500	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M2J83_00505	COG0601	transmembrane transport
M2J83_00515	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
M2J83_00525	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
M2J83_00530	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M2J83_00535	COG0431	NADPH-dependent FMN reductase
M2J83_00560	COG0583	DNA-binding transcription factor activity
M2J83_00570	COG4149	molybdate abc transporter
M2J83_00585	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
M2J83_00590	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
M2J83_00600	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
M2J83_00620	COG0028	Belongs to the TPP enzyme family
M2J83_00625	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
M2J83_00655	COG2922	Belongs to the Smg family
M2J83_00670	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
M2J83_00675	COG0183	Belongs to the thiolase family
M2J83_00680	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
M2J83_00685	COG1960	acyl-CoA dehydrogenase activity
M2J83_00705	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
M2J83_00715	COG0018	arginyl-trna synthetase
M2J83_00735	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
M2J83_00750	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
M2J83_00755	COG4774	siderophore transport
M2J83_00760	COG0066	3-isopropylmalate dehydratase activity
M2J83_00765	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
M2J83_00770	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
M2J83_00775	COG1804	L-carnitine dehydratase bile acid-inducible protein F
M2J83_00780	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
M2J83_00780	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
M2J83_00790	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
M2J83_00795	COG1335	isochorismatase
M2J83_00800	COG0583	DNA-binding transcription factor activity
M2J83_00820	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
M2J83_00825	COG1280	lysine exporter protein (LysE YggA)
M2J83_00830	COG0513	Belongs to the DEAD box helicase family
M2J83_00840	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
M2J83_00855	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
M2J83_00870	COG0154	amidase activity
M2J83_00885	COG0583	DNA-binding transcription factor activity
M2J83_00915	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
M2J83_00920	COG1127	ABC transporter
M2J83_00925	COG3218	ABC-type transport auxiliary lipoprotein component
M2J83_00925	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
M2J83_00940	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
M2J83_00945	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
M2J83_00955	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
M2J83_00985	COG0583	DNA-binding transcription factor activity
M2J83_01010	COG4680	protein conserved in bacteria
M2J83_01030	COG2358	TRAP transporter, solute receptor (TAXI family
M2J83_01040	COG0564	pseudouridine synthase activity
M2J83_01045	COG0252	asparaginase activity
M2J83_01070	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
M2J83_01075	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
M2J83_01080	COG3181	Tripartite tricarboxylate transporter family receptor
M2J83_01100	COG0559	Belongs to the binding-protein-dependent transport system permease family
M2J83_01125	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M2J83_01140	COG0758	DNA mediated transformation
M2J83_01145	COG0242	peptide deformylase activity
M2J83_01150	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
M2J83_01155	COG0697	spore germination
M2J83_01170	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
M2J83_01185	COG4336	lyase activity
M2J83_01190	COG0583	DNA-binding transcription factor activity
M2J83_01195	COG0859	PFAM glycosyl transferase family 9
M2J83_01205	COG1278	Cold shock
M2J83_01210	COG1210	Utp--glucose-1-phosphate uridylyltransferase
M2J83_01215	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
M2J83_01220	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
M2J83_01220	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
M2J83_01230	COG1686	Belongs to the peptidase S11 family
M2J83_01240	COG2921	Belongs to the UPF0250 family
M2J83_01245	COG0321	lipoyl(octanoyl) transferase activity
M2J83_01265	COG1024	Enoyl-CoA hydratase
M2J83_01270	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
M2J83_01280	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
M2J83_01325	COG0826	peptidase U32
M2J83_01335	COG3154	lipid carrier protein
M2J83_01360	COG0134	indole-3-glycerol-phosphate synthase activity
M2J83_01365	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
M2J83_01370	COG0512	Glutamine amidotransferase of anthranilate synthase
M2J83_01380	COG0546	phosphoglycolate phosphatase activity
M2J83_01390	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
M2J83_01395	COG2967	ApaG domain
M2J83_01400	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
M2J83_01405	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M2J83_01410	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
M2J83_01420	COG0840	transmembrane signaling receptor activity
M2J83_01430	COG1028	Short-chain dehydrogenase reductase Sdr
M2J83_01435	COG1535	isochorismatase
M2J83_01435	COG3433	isochorismatase activity
M2J83_01440	COG1169	isochorismate synthase
M2J83_01455	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M2J83_01455	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
M2J83_01460	COG3433	isochorismatase activity
M2J83_01460	COG1535	isochorismatase
M2J83_01465	COG1021	2,3-dihydroxybenzoate-AMP ligase
M2J83_01495	COG0683	leucine binding
M2J83_01510	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
M2J83_01545	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
M2J83_01550	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M2J83_01555	COG2819	hydrolase of the alpha beta superfamily
M2J83_01560	COG0513	Belongs to the DEAD box helicase family
M2J83_01565	COG2814	Major facilitator Superfamily
M2J83_01575	COG0583	DNA-binding transcription factor activity
M2J83_01585	COG1253	flavin adenine dinucleotide binding
M2J83_01620	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
M2J83_01630	COG2311	Membrane
M2J83_01670	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
M2J83_01690	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
M2J83_01695	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
M2J83_01705	COG0583	DNA-binding transcription factor activity
M2J83_01710	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M2J83_01720	COG0765	amino acid transport
M2J83_01725	COG0765	amino acid transport
M2J83_01730	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
M2J83_01735	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
M2J83_01750	COG3391	amine dehydrogenase activity
M2J83_01760	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
M2J83_01785	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
M2J83_01790	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
M2J83_01795	COG0210	DNA helicase
M2J83_01810	COG0067	glutamate synthase
M2J83_01810	COG0069	glutamate synthase activity
M2J83_01810	COG0070	glutamate synthase
M2J83_01815	COG1024	Enoyl-CoA hydratase
M2J83_01825	COG1804	L-carnitine dehydratase bile acid-inducible protein F
M2J83_01830	COG1250	3-hydroxyacyl-CoA dehydrogenase
M2J83_01860	COG2918	glutathione biosynthetic process
M2J83_01875	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
M2J83_01885	COG2223	nitrite transmembrane transporter activity
M2J83_01890	COG2860	membrane
M2J83_01895	COG1346	cytolysis
M2J83_01910	COG0251	oxidation-reduction process
M2J83_01925	COG5295	Hep Hag repeat protein
M2J83_01945	COG1280	lysine exporter protein (LysE YggA)
M2J83_01975	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
M2J83_01990	COG2096	Adenosyltransferase
M2J83_02005	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
M2J83_02010	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
M2J83_02020	COG0523	cobalamin synthesis protein
M2J83_02025	COG0735	belongs to the Fur family
M2J83_02040	COG1108	ABC-type Mn2 Zn2 transport systems permease components
M2J83_02045	COG0803	Belongs to the bacterial solute-binding protein 9 family
M2J83_02050	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
M2J83_02060	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
M2J83_02065	COG1560	Kdo2-lipid A biosynthetic process
M2J83_02075	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
M2J83_02080	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
M2J83_02085	COG1950	PFAM Membrane protein of
M2J83_02120	COG0275	rRNA processing
M2J83_02125	COG0730	response to heat
M2J83_02130	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
M2J83_02135	COG0129	dihydroxy-acid dehydratase activity
M2J83_02140	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
M2J83_02160	COG3181	Tripartite tricarboxylate transporter family receptor
M2J83_02170	COG0628	permease
M2J83_02215	COG3846	protein secretion by the type IV secretion system
M2J83_02225	COG3451	type IV secretory pathway VirB4
M2J83_02235	COG3838	Conjugal transfer protein Trbc
M2J83_02240	COG4962	Type ii secretion system protein e
M2J83_02260	COG0583	DNA-binding transcription factor activity
M2J83_02270	COG2249	NAD(P)H dehydrogenase (quinone) activity
M2J83_02275	COG0640	Transcriptional regulator
M2J83_02290	COG4959	Type IV secretory pathway protease TraF
M2J83_02305	COG1192	Involved in chromosome partitioning
M2J83_02335	COG5489	Protein of unknown function (DUF736)
M2J83_02360	COG2003	Belongs to the UPF0758 family
M2J83_02370	COG3621	Patatin-like phospholipase
M2J83_02430	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
M2J83_02445	COG1028	Short-chain dehydrogenase reductase Sdr
M2J83_02470	COG1021	2,3-dihydroxybenzoate-AMP ligase
M2J83_02485	COG2814	Major facilitator Superfamily
M2J83_02505	COG1846	Transcriptional regulator
M2J83_02520	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M2J83_02530	COG0789	Transcriptional regulator
M2J83_02540	COG4774	siderophore transport
M2J83_02545	COG4607	ABC-type enterochelin transport system periplasmic component
M2J83_02550	COG4604	ABC transporter, ATP-binding protein
M2J83_02555	COG4605	iron ion homeostasis
M2J83_02560	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M2J83_02565	COG1132	(ABC) transporter
M2J83_02570	COG1132	(ABC) transporter
M2J83_02570	COG2375	cellular response to nickel ion
M2J83_02575	COG0277	FAD linked oxidase domain protein
M2J83_02580	COG1304	FMN binding
M2J83_02585	COG2186	Transcriptional regulator
M2J83_02605	COG2188	Transcriptional regulator
M2J83_02610	COG1522	sequence-specific DNA binding
M2J83_02615	COG3844	kynureninase activity
M2J83_02620	COG1113	amino acid transport
M2J83_02650	COG3181	Tripartite tricarboxylate transporter family receptor
M2J83_02655	COG1349	DNA-binding transcription factor activity
M2J83_02660	COG3842	ATPase activity
M2J83_02675	COG0395	ABC-type sugar transport system, permease component
M2J83_02700	COG0861	Integral membrane protein TerC family
M2J83_02705	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
M2J83_02715	COG1671	Belongs to the UPF0178 family
M2J83_02725	COG1418	mRNA catabolic process
M2J83_02735	COG4948	Mandelate Racemase Muconate Lactonizing
M2J83_02745	COG0477	Major facilitator Superfamily
M2J83_02760	COG0154	amidase activity
M2J83_02770	COG0583	DNA-binding transcription factor activity
M2J83_02795	COG0326	Molecular chaperone. Has ATPase activity
M2J83_02800	COG4774	siderophore transport
M2J83_02805	COG3128	pkhd-type hydroxylase
M2J83_02830	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
M2J83_02835	COG1652	LysM domain
M2J83_02850	COG0220	tRNA (guanine-N7-)-methyltransferase activity
M2J83_02860	COG0582	viral genome integration into host DNA
M2J83_02910	COG0629	single-stranded DNA binding
M2J83_02915	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
M2J83_03110	COG2003	Belongs to the UPF0758 family
M2J83_03200	COG1674	ftsk spoiiie
M2J83_03200	COG0433	COG0433 Predicted ATPase
M2J83_03260	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
M2J83_03265	COG3842	ATPase activity
M2J83_03280	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
M2J83_03300	COG0789	Transcriptional regulator
M2J83_03310	COG2608	mercury ion transmembrane transporter activity
M2J83_03315	COG2608	mercury ion transmembrane transporter activity
M2J83_03320	COG0789	Transcriptional regulator
M2J83_03330	COG1120	ATPase activity
M2J83_03345	COG3586	endonuclease activity
M2J83_03355	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
M2J83_03365	COG0583	DNA-binding transcription factor activity
M2J83_03375	COG0464	growth
M2J83_03405	COG1535	isochorismatase
M2J83_03405	COG3433	isochorismatase activity
M2J83_03430	COG0583	DNA-binding transcription factor activity
M2J83_03435	COG0387	Pfam Sodium calcium exchanger
M2J83_03450	COG0477	Major facilitator Superfamily
M2J83_03455	COG0235	Class ii aldolase
M2J83_03470	COG3391	amine dehydrogenase activity
M2J83_03475	COG0590	tRNA wobble adenosine to inosine editing
M2J83_03480	COG3257	ureidoglycine aminohydrolase activity
M2J83_03485	COG0583	DNA-binding transcription factor activity
M2J83_03490	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
M2J83_03495	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M2J83_03495	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M2J83_03505	COG0489	protein tyrosine kinase activity
M2J83_03530	COG2081	HI0933 family
M2J83_03535	COG0509	glycine decarboxylation via glycine cleavage system
M2J83_03545	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
M2J83_03550	COG1765	OsmC-like protein
M2J83_03555	COG3278	Belongs to the heme-copper respiratory oxidase family
M2J83_03580	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
M2J83_03585	COG0469	pyruvate kinase activity
M2J83_03590	COG3193	protein, possibly involved in utilization of glycolate and propanediol
M2J83_03600	COG2084	Dehydrogenase
M2J83_03605	COG3622	Belongs to the hyi family
M2J83_03610	COG3960	tartronate-semialdehyde synthase activity
M2J83_03615	COG0583	DNA-binding transcription factor activity
M2J83_03625	COG2233	PERMEase
M2J83_03630	COG1942	4-Oxalocrotonate Tautomerase
M2J83_03635	COG0235	Class ii aldolase
M2J83_03645	COG3195	allantoin biosynthetic process
M2J83_03645	COG3648	Uricase
M2J83_03655	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
M2J83_03660	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
M2J83_03675	COG0438	transferase activity, transferring glycosyl groups
M2J83_03685	COG0438	transferase activity, transferring glycosyl groups
M2J83_03695	COG0277	FAD linked oxidase domain protein
M2J83_03705	COG0179	Fumarylacetoacetate (FAA) hydrolase
M2J83_03710	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
M2J83_03720	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M2J83_03730	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
M2J83_03740	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
M2J83_03755	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
M2J83_03760	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
M2J83_03765	COG0193	aminoacyl-tRNA hydrolase activity
M2J83_03775	COG0012	GTP binding
M2J83_03810	COG0488	(ABC) transporter
M2J83_03830	COG0288	reversible hydration of carbon dioxide
M2J83_03835	COG0583	DNA-binding transcription factor activity
M2J83_03865	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
M2J83_03875	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M2J83_03880	COG3088	subunit of a heme lyase
M2J83_03885	COG4235	cytochrome complex assembly
M2J83_03890	COG0785	Cytochrome C biogenesis protein
M2J83_03900	COG2169	Transcriptional regulator
M2J83_03900	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
M2J83_03920	COG0559	Belongs to the binding-protein-dependent transport system permease family
M2J83_03930	COG0411	ABC transporter
M2J83_03940	COG1858	cytochrome C peroxidase
M2J83_03945	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
M2J83_03950	COG1959	2 iron, 2 sulfur cluster binding
M2J83_03955	COG2346	COG2346, Truncated hemoglobins
M2J83_03960	COG0463	Glycosyl transferase, family 2
M2J83_04000	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
M2J83_04005	COG3383	formate dehydrogenase (NAD+) activity
M2J83_04020	COG1910	domain protein
M2J83_04025	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
M2J83_04035	COG0303	'Molybdopterin
M2J83_04040	COG0521	Mo-molybdopterin cofactor biosynthetic process
M2J83_04045	COG0314	molybdopterin synthase activity
M2J83_04055	COG0315	cyclic pyranopterin monophosphate synthase activity
M2J83_04085	COG0678	peroxiredoxin activity
M2J83_04100	COG0697	spore germination
M2J83_04105	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
M2J83_04140	COG2814	Major facilitator Superfamily
M2J83_04180	COG0815	Transfers the fatty acyl group on membrane lipoproteins
M2J83_04185	COG4535	Mg2 and Co2 transporter CorC
M2J83_04190	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
M2J83_04195	COG1702	phosphate starvation-inducible protein PhoH
M2J83_04200	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
M2J83_04215	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
M2J83_04220	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
M2J83_04225	COG1862	Preprotein translocase
M2J83_04230	COG0343	queuine tRNA-ribosyltransferase activity
M2J83_04235	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
M2J83_04240	COG2027	D-alanyl-D-alanine carboxypeptidase
M2J83_04245	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
M2J83_04255	COG4575	ribosome binding
M2J83_04270	COG0583	DNA-binding transcription factor activity
M2J83_04285	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M2J83_04300	COG0154	amidase activity
M2J83_04310	COG0477	Major facilitator Superfamily
M2J83_04325	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
M2J83_04335	COG0436	Aminotransferase
M2J83_04345	COG0280	phosphate acetyltransferase
M2J83_04345	COG0281	malic enzyme
M2J83_04355	COG2732	(Barnase) inhibitor
M2J83_04360	COG1385	rRNA (uridine-N3-)-methyltransferase activity
M2J83_04365	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
M2J83_04370	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
M2J83_04375	COG0126	phosphoglycerate kinase activity
M2J83_04395	COG0521	Mo-molybdopterin cofactor biosynthetic process
M2J83_04405	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
M2J83_04410	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
M2J83_04415	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
M2J83_04420	COG0009	L-threonylcarbamoyladenylate synthase
M2J83_04430	COG1012	belongs to the aldehyde dehydrogenase family
M2J83_04430	COG2030	dehydratase
M2J83_04435	COG1960	acyl-CoA dehydrogenase activity
M2J83_04445	COG0405	Gamma-glutamyltransferase
M2J83_04455	COG0579	oxidoreductase
M2J83_04460	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
M2J83_04465	COG0259	pyridoxamine-phosphate oxidase activity
M2J83_04475	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
M2J83_04490	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
M2J83_04495	COG1215	transferase activity, transferring glycosyl groups
M2J83_04505	COG0488	(ABC) transporter
M2J83_04525	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
M2J83_04530	COG2894	cell division
M2J83_04540	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
M2J83_04545	COG1271	oxidase subunit
M2J83_04550	COG1294	oxidase, subunit
M2J83_04555	COG0038	chloride channel
M2J83_04565	COG0514	ATP-dependent DNA helicase (RecQ)
M2J83_04570	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
M2J83_04575	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
M2J83_04580	COG0633	Ferredoxin
M2J83_04585	COG0488	(ABC) transporter
M2J83_04595	COG2001	Belongs to the MraZ family
M2J83_04600	COG0275	rRNA processing
M2J83_04605	COG3116	cell division
M2J83_04615	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
M2J83_04620	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
M2J83_04625	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
M2J83_04635	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
M2J83_04640	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
M2J83_04645	COG1181	Belongs to the D-alanine--D-alanine ligase family
M2J83_04650	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
M2J83_04665	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
M2J83_04675	COG0739	heme binding
M2J83_04675	COG1196	nuclear chromosome segregation
M2J83_04675	COG0741	lytic transglycosylase activity
M2J83_04680	COG0653	protein targeting
M2J83_04690	COG2239	Acts as a magnesium transporter
M2J83_04700	COG1473	amidohydrolase
M2J83_04705	COG0318	PFAM AMP-dependent synthetase and ligase
M2J83_04715	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M2J83_04715	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
M2J83_04730	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
M2J83_04735	COG2011	ABC-type metal ion transport system permease component
M2J83_04745	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M2J83_04750	COG0765	amino acid transport
M2J83_04755	COG1126	abc transporter atp-binding protein
M2J83_04780	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
M2J83_04785	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
M2J83_04790	COG0700	Nucleoside recognition
M2J83_04805	COG0204	Acyl-transferase
M2J83_04810	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
M2J83_04815	COG0751	glycine-tRNA ligase activity
M2J83_04820	COG0752	glycyl-tRNA synthetase alpha subunit
M2J83_04830	COG1024	Enoyl-CoA hydratase
M2J83_04840	COG1309	transcriptional regulator
M2J83_04850	COG2814	Major facilitator Superfamily
M2J83_04865	COG1573	uracil-dna glycosylase
M2J83_04870	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
M2J83_04875	COG0617	tRNA 3'-terminal CCA addition
M2J83_04885	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
M2J83_04890	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
M2J83_04895	COG1953	Uracil, thiamine, allantoin
M2J83_04900	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
M2J83_04905	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
M2J83_04910	COG0586	Pfam SNARE associated Golgi protein
M2J83_04915	COG0860	N-Acetylmuramoyl-L-alanine amidase
M2J83_04920	COG0802	atpase or kinase
M2J83_04930	COG3181	Tripartite tricarboxylate transporter family receptor
M2J83_04965	COG0463	Glycosyl transferase, family 2
M2J83_04970	COG0280	phosphate acetyltransferase
M2J83_04970	COG0281	malic enzyme
M2J83_04975	COG0583	DNA-binding transcription factor activity
M2J83_04980	COG1012	belongs to the aldehyde dehydrogenase family
M2J83_04985	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
M2J83_05005	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
M2J83_05035	COG1733	regulation of RNA biosynthetic process
M2J83_05040	COG2910	NAD(P)H-binding
M2J83_05050	COG2223	nitrite transmembrane transporter activity
M2J83_05055	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
M2J83_05060	COG4974	Belongs to the 'phage' integrase family
M2J83_05065	COG0725	ABC transporter, periplasmic molybdate-binding protein
M2J83_05070	COG4149	molybdate abc transporter
M2J83_05075	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
M2J83_05090	COG1074	ATP-dependent DNA helicase activity
M2J83_05125	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
M2J83_05145	COG3391	amine dehydrogenase activity
M2J83_05150	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
M2J83_05155	COG0505	Belongs to the CarA family
M2J83_05160	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
M2J83_05180	COG2233	PERMEase
M2J83_05185	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
M2J83_05190	COG1534	Rna-binding protein
M2J83_05195	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
M2J83_05200	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
M2J83_05210	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
M2J83_05220	COG0248	Ppx GppA phosphatase
M2J83_05225	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
M2J83_05245	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
M2J83_05250	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
M2J83_05300	COG1231	oxidoreductase activity
M2J83_05310	COG2323	membrane
M2J83_05320	COG1368	sulfuric ester hydrolase activity
M2J83_05350	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
M2J83_05355	COG3327	negative regulation of DNA-templated transcription, initiation
M2J83_05360	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
M2J83_05375	COG0009	L-threonylcarbamoyladenylate synthase
M2J83_05380	COG1994	Peptidase M50
M2J83_05385	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
M2J83_05390	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
M2J83_05405	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
M2J83_05415	COG0156	8-amino-7-oxononanoate synthase activity
M2J83_05420	COG2124	cytochrome p450
M2J83_05430	COG3135	benzoate transporter
M2J83_05435	COG2850	peptidyl-arginine hydroxylation
M2J83_05445	COG3391	amine dehydrogenase activity
M2J83_05455	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M2J83_05460	COG0577	efflux transmembrane transporter activity
M2J83_05460	COG1136	(ABC) transporter
M2J83_05465	COG1538	Outer membrane efflux protein
M2J83_05470	COG0363	glucosamine-6-phosphate deaminase activity
M2J83_05475	COG1132	(ABC) transporter
M2J83_05485	COG3181	Tripartite tricarboxylate transporter family receptor
M2J83_05495	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M2J83_05505	COG0668	transmembrane transport
M2J83_05550	COG0154	amidase activity
M2J83_05565	COG0483	inositol monophosphate 1-phosphatase activity
M2J83_05570	COG1253	flavin adenine dinucleotide binding
M2J83_05575	COG1968	undecaprenyl-diphosphatase activity
M2J83_05595	COG0215	cysteine-tRNA ligase activity
M2J83_05605	COG0825	malonyl-CoA metabolic process
M2J83_05610	COG0037	tRNA processing
M2J83_05635	COG0330	HflC and HflK could
M2J83_05650	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
M2J83_05670	COG4208	sulfate ABC transporter
M2J83_05675	COG3842	ATPase activity
M2J83_05685	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
M2J83_05715	COG1304	FMN binding
M2J83_05720	COG0435	Glutathione S-transferase
M2J83_05725	COG0655	NAD(P)H dehydrogenase (quinone) activity
M2J83_05745	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
M2J83_05750	COG2363	Small membrane protein
M2J83_05755	COG0598	Magnesium transport protein CorA
M2J83_05760	COG1960	acyl-CoA dehydrogenase activity
M2J83_05770	COG0747	negative chemotaxis
M2J83_05780	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M2J83_05785	COG4172	Belongs to the ABC transporter superfamily
M2J83_05795	COG3284	Transcriptional regulator
M2J83_05800	COG1012	belongs to the aldehyde dehydrogenase family
M2J83_05805	COG1454	alcohol dehydrogenase
M2J83_05810	COG1715	Restriction endonuclease
M2J83_05825	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
M2J83_05835	COG0183	Belongs to the thiolase family
M2J83_05840	COG0318	PFAM AMP-dependent synthetase and ligase
M2J83_05850	COG1028	Short-chain dehydrogenase reductase Sdr
M2J83_05855	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
M2J83_05880	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
M2J83_05910	COG3829	transcription factor binding
M2J83_05915	COG0477	Major facilitator Superfamily
M2J83_05925	COG0039	L-malate dehydrogenase activity
M2J83_05930	COG2188	Transcriptional regulator
M2J83_05935	COG2009	succinate dehydrogenase
M2J83_05945	COG1053	succinate dehydrogenase
M2J83_05950	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
M2J83_05955	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
M2J83_05960	COG0372	Belongs to the citrate synthase family
M2J83_05965	COG2186	Transcriptional regulator
M2J83_05970	COG1620	l-lactate permease
M2J83_05975	COG0280	phosphate acetyltransferase
M2J83_05975	COG0281	malic enzyme
M2J83_05980	COG0567	Dehydrogenase, E1 component
M2J83_05985	COG0508	dehydrogenase complex catalyzes the overall conversion of
M2J83_05990	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M2J83_05995	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
M2J83_06020	COG2183	response to ionizing radiation
M2J83_06025	COG1199	ATP-dependent helicase activity
M2J83_06035	COG1733	regulation of RNA biosynthetic process
M2J83_06060	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
M2J83_06070	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
M2J83_06070	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
M2J83_06085	COG0564	pseudouridine synthase activity
M2J83_06095	COG3243	poly(R)-hydroxyalkanoic acid synthase
M2J83_06100	COG1028	Short-chain dehydrogenase reductase Sdr
M2J83_06105	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
M2J83_06130	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
M2J83_06135	COG1187	pseudouridine synthase activity
M2J83_06140	COG0779	Required for maturation of 30S ribosomal subunits
M2J83_06145	COG2251	uridine kinase activity
M2J83_06145	COG0195	Participates in both transcription termination and antitermination
M2J83_06150	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
M2J83_06155	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
M2J83_06160	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
M2J83_06165	COG1217	gtp-binding protein TYPA
M2J83_06170	COG0446	pyridine nucleotide-disulphide oxidoreductase
M2J83_06180	COG4160	amino acid transport
M2J83_06185	COG4215	(ABC) transporter
M2J83_06205	COG1283	sodium-dependent phosphate transmembrane transporter activity
M2J83_06215	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
M2J83_06225	COG0456	acetyltransferase
M2J83_06230	COG0501	Belongs to the peptidase M48B family
M2J83_06245	COG1722	exodeoxyribonuclease VII activity
M2J83_06250	COG0142	geranyltranstransferase activity
M2J83_06260	COG1469	GTP cyclohydrolase I activity
M2J83_06265	COG0360	Binds together with S18 to 16S ribosomal RNA
M2J83_06270	COG2965	DNA replication, synthesis of RNA primer
M2J83_06275	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
M2J83_06285	COG0305	Participates in initiation and elongation during chromosome replication
M2J83_06295	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
M2J83_06300	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
M2J83_06305	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
M2J83_06315	COG0436	Aminotransferase
M2J83_06330	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
M2J83_06340	COG1562	ergosterol biosynthetic process
M2J83_06345	COG1562	ergosterol biosynthetic process
M2J83_06350	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
M2J83_06355	COG1028	Short-chain dehydrogenase reductase Sdr
M2J83_06380	COG3842	ATPase activity
M2J83_06385	COG1176	ABC-type spermidine putrescine transport system, permease component I
M2J83_06390	COG1177	transmembrane transport
M2J83_06395	COG1393	Belongs to the ArsC family
M2J83_06400	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
M2J83_06405	COG0704	Plays a role in the regulation of phosphate uptake
M2J83_06410	COG2203	Gaf domain
M2J83_06410	COG3706	GGDEF domain
M2J83_06410	COG5001	Diguanylate cyclase
M2J83_06410	COG4251	negative regulation of phosphorylation
M2J83_06415	COG0659	secondary active sulfate transmembrane transporter activity
M2J83_06420	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
M2J83_06425	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
M2J83_06425	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
M2J83_06430	COG1643	Atp-dependent helicase
M2J83_06440	COG0438	transferase activity, transferring glycosyl groups
M2J83_06445	COG0726	polysaccharide deacetylase
M2J83_06460	COG0438	transferase activity, transferring glycosyl groups
M2J83_06485	COG1132	(ABC) transporter
M2J83_06505	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
M2J83_06510	COG1228	amidohydrolase
M2J83_06550	COG2186	Transcriptional regulator
M2J83_06555	COG0277	FAD linked oxidase domain protein
M2J83_06560	COG0277	FAD linked oxidase domain protein
M2J83_06565	COG0247	lactate metabolic process
M2J83_06590	COG0628	permease
M2J83_06595	COG1283	sodium-dependent phosphate transmembrane transporter activity
M2J83_06610	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
M2J83_06620	COG0697	spore germination
M2J83_06640	COG3094	Invasion gene expression up-regulator, SirB
M2J83_06650	COG0640	Transcriptional regulator
M2J83_06675	COG0659	secondary active sulfate transmembrane transporter activity
M2J83_06680	COG1262	PFAM Formylglycine-generating sulfatase enzyme
M2J83_06690	COG2314	TM2 domain
M2J83_06695	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
M2J83_06700	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
M2J83_06705	COG0791	NLP P60 protein
M2J83_06725	COG1360	Flagellar Motor Protein
M2J83_06735	COG0835	chemotaxis
M2J83_06740	COG0840	transmembrane signaling receptor activity
M2J83_06745	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
M2J83_06755	COG0745	RESPONSE REGULATOR receiver
M2J83_06760	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
M2J83_06770	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
M2J83_06780	COG3550	peptidyl-serine autophosphorylation
M2J83_06805	COG1815	bacterial-type flagellum-dependent cell motility
M2J83_06810	COG1558	bacterial-type flagellum-dependent cell motility
M2J83_06815	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
M2J83_06855	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
M2J83_06880	COG2176	DNA-directed DNA polymerase activity
M2J83_06890	COG1987	bacterial-type flagellum assembly
M2J83_06905	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
M2J83_06930	COG1157	protein secretion by the type III secretion system
M2J83_06945	COG1766	The M ring may be actively involved in energy transduction
M2J83_06950	COG1677	Flagellar hook-basal body complex protein FliE
M2J83_06955	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
M2J83_06980	COG1334	flagellar protein FlaG
M2J83_06985	COG1191	sigma factor activity
M2J83_07040	COG1262	PFAM Formylglycine-generating sulfatase enzyme
M2J83_07060	COG2733	membrane
M2J83_07065	COG0840	transmembrane signaling receptor activity
M2J83_07070	COG0840	transmembrane signaling receptor activity
M2J83_07095	COG2610	gluconate transmembrane transporter activity
M2J83_07105	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
M2J83_07115	COG4521	taurine ABC transporter
M2J83_07120	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
M2J83_07125	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
M2J83_07130	COG1028	Short-chain dehydrogenase reductase Sdr
M2J83_07135	COG0583	DNA-binding transcription factor activity
M2J83_07165	COG2824	Alkylphosphonate utilization operon protein PhnA
M2J83_07180	COG4771	TonB-dependent receptor
M2J83_07185	COG1858	cytochrome C peroxidase
M2J83_07205	COG1113	amino acid transport
M2J83_07225	COG0583	DNA-binding transcription factor activity
M2J83_07230	COG3755	Protein conserved in bacteria
M2J83_07235	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
M2J83_07270	COG0446	pyridine nucleotide-disulphide oxidoreductase
M2J83_07295	COG1278	Cold shock
M2J83_07300	COG0642	Histidine kinase
M2J83_07310	COG3278	Belongs to the heme-copper respiratory oxidase family
M2J83_07320	COG2863	cytochrome
M2J83_07325	COG3258	Cytochrome c
M2J83_07355	COG0025	NhaP-type Na H and K H
M2J83_07370	COG1289	transmembrane transporter activity
M2J83_07375	COG2252	PERMEase
M2J83_07395	COG1999	signal sequence binding
M2J83_07410	COG0069	glutamate synthase activity
M2J83_07420	COG1846	Transcriptional regulator
M2J83_07430	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
M2J83_07470	COG1028	Short-chain dehydrogenase reductase Sdr
M2J83_07480	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
M2J83_07480	COG3264	Mechanosensitive ion channel
M2J83_07485	COG3264	Mechanosensitive ion channel
M2J83_07485	COG1511	domain protein
M2J83_07490	COG0477	Major facilitator Superfamily
M2J83_07505	COG1396	sequence-specific DNA binding
M2J83_07510	COG3437	response regulator, receiver
M2J83_07515	COG2198	Histidine kinase
M2J83_07515	COG0784	Response regulator, receiver
M2J83_07515	COG2205	protein histidine kinase activity
M2J83_07520	COG2239	Acts as a magnesium transporter
M2J83_07530	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
M2J83_07535	COG1490	D-aminoacyl-tRNA deacylase activity
M2J83_07550	COG0456	acetyltransferase
M2J83_07560	COG0501	Belongs to the peptidase M48B family
M2J83_07565	COG2814	Major facilitator Superfamily
M2J83_07570	COG0582	viral genome integration into host DNA
M2J83_07730	COG0740	serine-type endopeptidase activity
M2J83_07835	COG4115	mRNA cleavage
M2J83_07840	COG2161	toxin-antitoxin pair type II binding
M2J83_07970	COG3772	lysozyme
M2J83_08020	COG2199	diguanylate cyclase activity
M2J83_08035	COG1522	sequence-specific DNA binding
M2J83_08040	COG0626	cystathionine gamma-synthase activity
M2J83_08050	COG0494	nUDIX hydrolase
M2J83_08055	COG2832	Protein of unknown function (DUF454)
M2J83_08065	COG0137	argininosuccinate synthase activity
M2J83_08080	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
M2J83_08090	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
M2J83_08095	COG2205	protein histidine kinase activity
M2J83_08100	COG0745	RESPONSE REGULATOR receiver
M2J83_08105	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
M2J83_08115	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
M2J83_08120	COG0268	Binds directly to 16S ribosomal RNA
M2J83_08125	COG0728	peptidoglycan biosynthetic process
M2J83_08135	COG0563	adenylate kinase activity
M2J83_08140	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
M2J83_08145	COG2835	tetraacyldisaccharide 4'-kinase activity
M2J83_08155	COG0848	biopolymer transport protein
M2J83_08160	COG0811	peptide transport
M2J83_08165	COG1570	exodeoxyribonuclease VII activity
M2J83_08170	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
M2J83_08180	COG0183	Belongs to the thiolase family
M2J83_08190	COG1278	Cold shock
M2J83_08195	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
M2J83_08200	COG0542	response to heat
M2J83_08205	COG2995	paraquat-inducible protein a
M2J83_08210	COG3008	intermembrane lipid transfer
M2J83_08210	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
M2J83_08265	COG0300	oxidoreductase activity
M2J83_08275	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
M2J83_08280	COG0756	dUTP diphosphatase activity
M2J83_08290	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
M2J83_08295	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
M2J83_08300	COG0196	riboflavin kinase activity
M2J83_08305	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
M2J83_08310	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
M2J83_08310	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
M2J83_08320	COG0210	DNA helicase
M2J83_08375	COG0488	(ABC) transporter
M2J83_08380	COG2890	protein-(glutamine-N5) methyltransferase activity
M2J83_08385	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
M2J83_08390	COG2171	N-acyltransferase activity
M2J83_08400	COG2207	Transcriptional regulator
M2J83_08410	COG3273	potassium ion transport
M2J83_08410	COG0471	metal ion transport
M2J83_08455	COG0789	Transcriptional regulator
M2J83_08470	COG1804	L-carnitine dehydratase bile acid-inducible protein F
M2J83_08475	COG0544	peptidyl-prolyl cis-trans isomerase activity
M2J83_08480	COG0740	serine-type endopeptidase activity
M2J83_08490	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
M2J83_08500	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
M2J83_08510	COG0556	nucleotide-excision repair
M2J83_08515	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
M2J83_08525	COG1104	cysteine desulfurase activity
M2J83_08535	COG0316	Belongs to the HesB IscA family
M2J83_08545	COG3181	Tripartite tricarboxylate transporter family receptor
M2J83_08550	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
M2J83_08555	COG4221	oxidoreductase activity
M2J83_08565	COG0840	transmembrane signaling receptor activity
M2J83_08570	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
M2J83_08575	COG0697	spore germination
M2J83_08580	COG0385	Bile acid
M2J83_08590	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
M2J83_08605	COG1136	(ABC) transporter
M2J83_08610	COG0084	hydrolase, TatD family'
M2J83_08625	COG0613	PHP domain protein
M2J83_08635	COG0047	phosphoribosylformylglycinamidine synthase activity
M2J83_08635	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
M2J83_08660	COG0518	GMP synthase (glutamine-hydrolyzing) activity
M2J83_08660	COG0519	Catalyzes the synthesis of GMP from XMP
M2J83_08685	COG4691	Plasmid stability protein
M2J83_08715	COG0798	PFAM Bile acid sodium symporter
M2J83_08755	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
M2J83_08805	COG2076	Multidrug Resistance protein
M2J83_08810	COG1028	Short-chain dehydrogenase reductase Sdr
M2J83_08815	COG0583	DNA-binding transcription factor activity
M2J83_08830	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
M2J83_08840	COG1960	acyl-CoA dehydrogenase activity
M2J83_08850	COG2378	regulation of single-species biofilm formation
M2J83_08855	COG0523	cobalamin synthesis protein
M2J83_08860	COG1469	GTP cyclohydrolase I activity
M2J83_08865	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
M2J83_08875	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
M2J83_08880	COG0735	belongs to the Fur family
M2J83_08885	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
M2J83_08905	COG0745	RESPONSE REGULATOR receiver
M2J83_08910	COG2207	Transcriptional regulator
M2J83_08930	COG1942	4-Oxalocrotonate Tautomerase
M2J83_08945	COG2070	2-Nitropropane dioxygenase
M2J83_08970	COG1309	transcriptional regulator
M2J83_08995	COG0625	glutathione transferase activity
M2J83_09000	COG0740	serine-type endopeptidase activity
M2J83_09050	COG1804	L-carnitine dehydratase bile acid-inducible protein F
M2J83_09060	COG1960	acyl-CoA dehydrogenase activity
M2J83_09085	COG0640	Transcriptional regulator
M2J83_09110	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
M2J83_09140	COG3485	protocatechuate 3,4-dioxygenase
M2J83_09150	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
M2J83_09155	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
M2J83_09165	COG3135	benzoate transporter
M2J83_09170	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
M2J83_09175	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
M2J83_09185	COG4555	ABC transporter
M2J83_09195	COG2197	response regulator
M2J83_09200	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
M2J83_09225	COG1846	Transcriptional regulator
M2J83_09230	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M2J83_09235	COG2271	Major facilitator Superfamily
M2J83_09245	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
M2J83_09255	COG0697	spore germination
M2J83_09280	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
M2J83_09285	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
M2J83_09290	COG0667	Aldo Keto reductase
M2J83_09310	COG0582	viral genome integration into host DNA
M2J83_09350	COG0582	viral genome integration into host DNA
M2J83_09520	COG3728	DNA packaging
M2J83_09520	COG5484	DNA packaging
M2J83_09525	COG5410	chromosome segregation
M2J83_09630	COG3772	lysozyme
M2J83_09670	COG1272	protein, Hemolysin III
M2J83_09675	COG3422	double-strand break repair
M2J83_09695	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M2J83_09700	COG0765	amino acid transport
M2J83_09705	COG0765	amino acid transport
M2J83_09710	COG1126	abc transporter atp-binding protein
M2J83_09760	COG2871	sodium ion transport
M2J83_09790	COG2814	Major facilitator Superfamily
M2J83_09800	COG1280	lysine exporter protein (LysE YggA)
M2J83_09820	COG0402	S-adenosylhomocysteine deaminase activity
M2J83_09845	COG0330	HflC and HflK could
M2J83_09850	COG1585	Membrane protein implicated in regulation of membrane protease activity
M2J83_09855	COG2226	methyltransferase
M2J83_09865	COG3042	response to heat
M2J83_09875	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M2J83_09895	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
M2J83_09900	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
M2J83_09915	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
M2J83_09920	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
M2J83_09950	COG0291	Belongs to the bacterial ribosomal protein bL35 family
M2J83_09955	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
M2J83_09960	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
M2J83_09965	COG0072	phenylalanine-tRNA ligase activity
M2J83_09965	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M2J83_09980	COG2833	Protein of unknown function (DUF455)
M2J83_09990	COG5265	(ABC) transporter
M2J83_09995	COG1959	2 iron, 2 sulfur cluster binding
M2J83_10000	COG0719	Fe-S assembly protein
M2J83_10005	COG0396	ATPase activity
M2J83_10010	COG0719	Fe-S assembly protein
M2J83_10020	COG0822	iron-sulfur transferase activity
M2J83_10025	COG2151	metal-sulfur cluster biosynthetic enzyme
M2J83_10045	COG1538	Outer membrane efflux protein
M2J83_10080	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
M2J83_10085	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
M2J83_10090	COG1181	Belongs to the D-alanine--D-alanine ligase family
M2J83_10110	COG0747	negative chemotaxis
M2J83_10115	COG0601	transmembrane transport
M2J83_10120	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M2J83_10125	COG4172	Belongs to the ABC transporter superfamily
M2J83_10135	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
M2J83_10180	COG3048	D-serine ammonia-lyase activity
M2J83_10185	COG3258	Cytochrome c
M2J83_10200	COG3949	Membrane
M2J83_10210	COG1262	PFAM Formylglycine-generating sulfatase enzyme
M2J83_10225	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
M2J83_10230	COG0569	domain protein
M2J83_10235	COG1902	pentaerythritol trinitrate reductase activity
M2J83_10245	COG1610	YqeY-like protein
M2J83_10250	COG0587	DNA-directed DNA polymerase activity
M2J83_10285	COG3181	Tripartite tricarboxylate transporter family receptor
M2J83_10290	COG0583	DNA-binding transcription factor activity
M2J83_10295	COG1686	Belongs to the peptidase S11 family
M2J83_10310	COG1360	Flagellar Motor Protein
M2J83_10320	COG1028	Short-chain dehydrogenase reductase Sdr
M2J83_10325	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M2J83_10330	COG4221	oxidoreductase activity
M2J83_10340	COG0307	riboflavin synthase, alpha
M2J83_10385	COG3846	protein secretion by the type IV secretion system
M2J83_10400	COG3451	type IV secretory pathway VirB4
M2J83_10410	COG3838	Conjugal transfer protein Trbc
M2J83_10415	COG4962	Type ii secretion system protein e
M2J83_10435	COG0583	DNA-binding transcription factor activity
M2J83_10490	COG4959	Type IV secretory pathway protease TraF
M2J83_10505	COG1192	Involved in chromosome partitioning
M2J83_10545	COG5489	Protein of unknown function (DUF736)
M2J83_10580	COG2003	Belongs to the UPF0758 family
M2J83_10655	COG2233	PERMEase
M2J83_10660	COG0071	Belongs to the small heat shock protein (HSP20) family
M2J83_10665	COG1473	amidohydrolase
M2J83_10705	COG2816	NAD+ diphosphatase activity
M2J83_10710	COG1561	YicC-like family, N-terminal region
M2J83_10725	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
M2J83_10730	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
M2J83_10735	COG0635	Involved in the biosynthesis of porphyrin-containing compound
M2J83_10740	COG0174	glutamine synthetase
M2J83_10745	COG2153	protein acetylation
M2J83_10765	COG3842	ATPase activity
M2J83_10770	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
M2J83_10775	COG1840	ABC-type Fe3 transport system, periplasmic component
M2J83_10790	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
M2J83_10800	COG0783	Belongs to the Dps family
M2J83_10810	COG3842	ATPase activity
M2J83_10815	COG0395	ABC-type sugar transport system, permease component
M2J83_10820	COG1175	transmembrane transport
M2J83_10825	COG1653	transport
M2J83_10840	COG0559	Belongs to the binding-protein-dependent transport system permease family
M2J83_10860	COG0625	glutathione transferase activity
M2J83_10870	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
M2J83_10875	COG1028	Short-chain dehydrogenase reductase Sdr
M2J83_10885	COG0114	fumarate hydratase activity
M2J83_10890	COG2133	pyrroloquinoline quinone binding
M2J83_10895	COG2226	methyltransferase
M2J83_10900	COG0589	response to stress
M2J83_10910	COG2207	Transcriptional regulator
M2J83_10925	COG1012	belongs to the aldehyde dehydrogenase family
M2J83_10930	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M2J83_10935	COG2807	transmembrane transport
M2J83_10945	COG0583	DNA-binding transcription factor activity
M2J83_10975	COG0583	DNA-binding transcription factor activity
M2J83_10980	COG4974	Belongs to the 'phage' integrase family
M2J83_10995	COG2132	Multicopper oxidase
M2J83_11000	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
M2J83_11170	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
M2J83_11200	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
M2J83_11205	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
M2J83_11210	COG0697	spore germination
M2J83_11290	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
M2J83_11295	COG0210	DNA helicase
M2J83_11320	COG2003	Belongs to the UPF0758 family
M2J83_11410	COG2894	cell division
M2J83_11415	COG1028	Short-chain dehydrogenase reductase Sdr
M2J83_11440	COG3038	cytochrome b561
M2J83_11450	COG2353	YceI-like domain
M2J83_11455	COG1393	Belongs to the ArsC family
M2J83_11460	COG0625	glutathione transferase activity
M2J83_11485	COG0084	hydrolase, TatD family'
M2J83_11490	COG0470	DNA polymerase III
M2J83_11500	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
M2J83_11520	COG1960	acyl-CoA dehydrogenase activity
M2J83_11525	COG2914	Belongs to the UPF0125 (RnfH) family
M2J83_11530	COG2867	negative regulation of translational initiation
M2J83_11535	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
M2J83_11540	COG1252	NADH dehydrogenase
M2J83_11565	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
M2J83_11570	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
M2J83_11575	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
M2J83_11585	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
M2J83_11590	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
M2J83_11600	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
M2J83_11610	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
M2J83_11615	COG0575	Belongs to the CDS family
M2J83_11620	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
M2J83_11625	COG0233	cytoplasmic translational termination
M2J83_11630	COG0528	UMP kinase activity
M2J83_11635	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
M2J83_11640	COG0052	Belongs to the universal ribosomal protein uS2 family
M2J83_11645	COG0024	Methionine aminopeptidase
M2J83_11650	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
M2J83_11675	COG1286	toxin biosynthetic process
M2J83_11685	COG0285	dihydrofolate synthase activity
M2J83_11690	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M2J83_11695	COG0508	dehydrogenase complex catalyzes the overall conversion of
M2J83_11700	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
M2J83_11715	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
M2J83_11725	COG1999	signal sequence binding
M2J83_11730	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
M2J83_11735	COG0640	Transcriptional regulator
M2J83_11750	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
M2J83_11755	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
M2J83_11760	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
M2J83_11765	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
M2J83_11770	COG1028	Short-chain dehydrogenase reductase Sdr
M2J83_11775	COG1028	Short-chain dehydrogenase reductase Sdr
M2J83_11795	COG0183	Belongs to the thiolase family
M2J83_11815	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
M2J83_11825	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
M2J83_11830	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M2J83_11835	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
M2J83_11855	COG0183	Belongs to the thiolase family
M2J83_11860	COG0183	Belongs to the thiolase family
M2J83_11870	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
M2J83_11905	COG0194	GDP metabolic process
M2J83_11910	COG1758	RNA polymerase activity
M2J83_11915	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
M2J83_11925	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
M2J83_11930	COG0739	heme binding
M2J83_11935	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
M2J83_11940	COG0584	glycerophosphoryl diester phosphodiesterase
M2J83_11945	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
M2J83_11950	COG1187	pseudouridine synthase activity
M2J83_11955	COG3161	chorismate lyase activity
M2J83_11960	COG2814	Major facilitator Superfamily
M2J83_11965	COG0656	L-ascorbic acid biosynthetic process
M2J83_11975	COG0668	transmembrane transport
M2J83_11980	COG0165	Argininosuccinate lyase
M2J83_11985	COG1846	Transcriptional regulator
M2J83_11985	COG1940	carbohydrate kinase activity
M2J83_11995	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M2J83_12005	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
M2J83_12015	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
M2J83_12020	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
M2J83_12025	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
M2J83_12030	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
M2J83_12035	COG2252	PERMEase
M2J83_12040	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M2J83_12060	COG0488	(ABC) transporter
M2J83_12065	COG1619	proteins homologs of microcin C7 resistance protein MccF
M2J83_12070	COG0590	tRNA wobble adenosine to inosine editing
M2J83_12075	COG1131	(ABC) transporter
M2J83_12080	COG0842	Transport permease protein
M2J83_12090	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
M2J83_12090	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
M2J83_12095	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
M2J83_12100	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
M2J83_12105	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M2J83_12115	COG2022	thiamine diphosphate biosynthetic process
M2J83_12135	COG1414	Transcriptional regulator
M2J83_12145	COG0730	response to heat
M2J83_12155	COG1666	GTP binding
M2J83_12160	COG0318	PFAM AMP-dependent synthetase and ligase
M2J83_12165	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
M2J83_12170	COG0519	Catalyzes the synthesis of GMP from XMP
M2J83_12170	COG0518	GMP synthase (glutamine-hydrolyzing) activity
M2J83_12175	COG2207	Transcriptional regulator
M2J83_12185	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M2J83_12190	COG0135	phosphoribosylanthranilate isomerase activity
M2J83_12195	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
M2J83_12205	COG0101	tRNA pseudouridine synthase activity
M2J83_12215	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
M2J83_12240	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
M2J83_12250	COG4566	intracellular signal transduction
M2J83_12265	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
M2J83_12270	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
M2J83_12280	COG1295	ribonuclease BN
M2J83_12290	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
M2J83_12325	COG4964	Belongs to the GSP D family
M2J83_12365	COG1595	DNA-templated transcription, initiation
M2J83_12385	COG2959	enzyme of heme biosynthesis
M2J83_12395	COG0181	hydroxymethylbilane synthase activity
M2J83_12400	COG0861	Integral membrane protein TerC family
M2J83_12410	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
M2J83_12415	COG0045	succinate-CoA ligase (ADP-forming) activity
M2J83_12430	COG0583	DNA-binding transcription factor activity
M2J83_12435	COG2137	regulation of response to DNA damage stimulus
M2J83_12440	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
M2J83_12455	COG0477	Major facilitator Superfamily
M2J83_12470	COG0318	PFAM AMP-dependent synthetase and ligase
M2J83_12475	COG1024	Enoyl-CoA hydratase
M2J83_12480	COG3162	membrane
M2J83_12495	COG0540	Belongs to the ATCase OTCase family
M2J83_12510	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
M2J83_12525	COG2070	2-Nitropropane dioxygenase
M2J83_12535	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
M2J83_12535	COG2111	Na H antiporter
M2J83_12540	COG1006	Multisubunit Na H antiporter MnhC subunit
M2J83_12545	COG0651	ATP synthesis coupled electron transport
M2J83_12555	COG2212	antiporter activity
M2J83_12570	COG3158	transport of potassium into the cell
M2J83_12575	COG0642	Histidine kinase
M2J83_12600	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
M2J83_12605	COG4208	sulfate ABC transporter
M2J83_12610	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
M2J83_12615	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
M2J83_12635	COG1278	Cold shock
M2J83_12650	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
M2J83_12650	COG1648	precorrin-2 dehydrogenase activity
M2J83_12680	COG0535	radical SAM domain protein
M2J83_12685	COG1648	precorrin-2 dehydrogenase activity
M2J83_12685	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
M2J83_12695	COG2010	Cytochrome c
M2J83_12700	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M2J83_12705	COG0626	cystathionine gamma-synthase activity
M2J83_12710	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
M2J83_12715	COG0557	exoribonuclease II activity
M2J83_12735	COG0765	amino acid transport
M2J83_12740	COG0765	amino acid transport
M2J83_12745	COG1126	abc transporter atp-binding protein
M2J83_12760	COG1850	ribulose-bisphosphate carboxylase activity
M2J83_12780	COG2375	cellular response to nickel ion
M2J83_12795	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M2J83_12810	COG0583	DNA-binding transcription factor activity
M2J83_12815	COG3842	ATPase activity
M2J83_12820	COG1175	transmembrane transport
M2J83_12825	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
M2J83_12830	COG1840	ABC-type Fe3 transport system, periplasmic component
M2J83_12850	COG0412	Dienelactone hydrolase
M2J83_12855	COG3530	Putative quorum-sensing-regulated virulence factor
M2J83_12860	COG0625	glutathione transferase activity
M2J83_12865	COG1741	Belongs to the pirin family
M2J83_12875	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
M2J83_12880	COG2814	Major facilitator Superfamily
M2J83_12885	COG2807	transmembrane transport
M2J83_12890	COG2207	Transcriptional regulator
M2J83_12895	COG3135	benzoate transporter
M2J83_12920	COG1529	Aldehyde oxidase and xanthine dehydrogenase
M2J83_12930	COG0402	S-adenosylhomocysteine deaminase activity
M2J83_12940	COG0745	RESPONSE REGULATOR receiver
M2J83_12945	COG2205	protein histidine kinase activity
M2J83_12960	COG0828	Belongs to the bacterial ribosomal protein bS21 family
M2J83_12965	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
M2J83_12970	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
M2J83_12980	COG0330	HflC and HflK could
M2J83_12985	COG0330	HflC and HflK could
M2J83_12990	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
M2J83_12995	COG1923	regulation of RNA biosynthetic process
M2J83_13005	COG1160	GTP binding
M2J83_13010	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
M2J83_13015	COG2976	Protein conserved in bacteria
M2J83_13035	COG0820	rRNA (adenine-C2-)-methyltransferase activity
M2J83_13040	COG0105	UTP biosynthetic process
M2J83_13050	COG0336	Belongs to the RNA methyltransferase TrmD family
M2J83_13060	COG0228	four-way junction DNA binding
M2J83_13065	COG0425	Belongs to the sulfur carrier protein TusA family
M2J83_13070	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
M2J83_13085	COG2351	hydroxyisourate hydrolase activity
M2J83_13120	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M2J83_13145	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
M2J83_13150	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
M2J83_13175	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M2J83_13180	COG0601	transmembrane transport
M2J83_13210	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
M2J83_13215	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
M2J83_13220	COG0542	response to heat
M2J83_13225	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
M2J83_13240	COG0348	domain, Protein
M2J83_13260	COG3278	Belongs to the heme-copper respiratory oxidase family
M2J83_13270	COG2217	Heavy metal translocating P-type atpase
M2J83_13275	COG2224	Isocitrate lyase
M2J83_13280	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
M2J83_13280	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
M2J83_13300	COG1472	Belongs to the glycosyl hydrolase 3 family
M2J83_13305	COG0736	holo-[acyl-carrier-protein] synthase activity
M2J83_13315	COG2050	protein possibly involved in aromatic compounds catabolism
M2J83_13320	COG1024	Enoyl-CoA hydratase
M2J83_13325	COG1012	belongs to the aldehyde dehydrogenase family
M2J83_13330	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
M2J83_13335	COG2151	metal-sulfur cluster biosynthetic enzyme
M2J83_13340	COG3396	Phenylacetate-CoA oxygenase
M2J83_13345	COG3460	Phenylacetate-CoA oxygenase
M2J83_13350	COG3396	Phenylacetate-CoA oxygenase
M2J83_13355	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
M2J83_13360	COG0501	Belongs to the peptidase M48B family
M2J83_13365	COG1162	GTPase activity
M2J83_13375	COG0335	large ribosomal subunit rRNA binding
M2J83_13395	COG0450	alkyl hydroperoxide reductase
M2J83_13400	COG1960	acyl-CoA dehydrogenase activity
M2J83_13415	COG0123	including yeast histone deacetylase and acetoin utilization protein
M2J83_13420	COG2951	lytic endotransglycosylase activity
M2J83_13430	COG1555	photosystem II stabilization
M2J83_13430	COG1596	polysaccharide export
M2J83_13435	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M2J83_13440	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
M2J83_13445	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
M2J83_13465	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
M2J83_13470	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
M2J83_13475	COG0287	Prephenate dehydrogenase
M2J83_13485	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
M2J83_13500	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
M2J83_13520	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
M2J83_13530	COG4771	TonB-dependent receptor
M2J83_13545	COG0753	catalase activity
M2J83_13555	COG4335	DNA alkylation repair
M2J83_13565	COG0436	Aminotransferase
M2J83_13575	COG0251	oxidation-reduction process
M2J83_13580	COG1309	transcriptional regulator
M2J83_13590	COG0488	(ABC) transporter
M2J83_13645	COG0625	glutathione transferase activity
M2J83_13655	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
M2J83_13660	COG1280	lysine exporter protein (LysE YggA)
M2J83_13680	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
M2J83_13690	COG5002	protein histidine kinase activity
M2J83_13695	COG2046	Belongs to the sulfate adenylyltransferase family
M2J83_13700	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
M2J83_13715	COG0840	transmembrane signaling receptor activity
M2J83_13720	COG2119	membrane
M2J83_13735	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
M2J83_13740	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
M2J83_13755	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
M2J83_13760	COG2321	neutral zinc metallopeptidase
M2J83_13780	COG2175	clavaminate synthase activity
M2J83_13785	COG1846	Transcriptional regulator
M2J83_13790	COG0347	Belongs to the P(II) protein family
M2J83_13795	COG0004	ammonium transporteR
M2J83_13800	COG3909	cytochrome
M2J83_13810	COG0625	glutathione transferase activity
M2J83_13820	COG0657	acetylesterase activity
M2J83_13835	COG0730	response to heat
M2J83_13840	COG0482	sulfurtransferase activity
M2J83_13845	COG0277	FAD linked oxidase domain protein
M2J83_13850	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
M2J83_13855	COG2879	small protein
M2J83_13860	COG1966	Carbon starvation protein
M2J83_13865	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M2J83_13870	COG0765	amino acid transport
M2J83_13875	COG0765	amino acid transport
M2J83_13880	COG1126	abc transporter atp-binding protein
M2J83_13885	COG0028	Belongs to the TPP enzyme family
M2J83_13890	COG1012	belongs to the aldehyde dehydrogenase family
M2J83_13895	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
M2J83_13900	COG1028	Short-chain dehydrogenase reductase Sdr
M2J83_13910	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
M2J83_13915	COG1116	anion transmembrane transporter activity
M2J83_13930	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
M2J83_13935	COG1414	Transcriptional regulator
M2J83_13945	COG5285	phytanoyl-CoA dioxygenase
M2J83_13950	COG0662	Cupin 2, conserved barrel domain protein
M2J83_13960	COG0456	acetyltransferase
M2J83_13965	COG1846	Transcriptional regulator
M2J83_13975	COG0312	modulator of DNA gyrase
M2J83_13990	COG0308	aminopeptidase N
M2J83_13995	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
M2J83_14010	COG0473	3-isopropylmalate dehydrogenase activity
M2J83_14020	COG0433	COG0433 Predicted ATPase
M2J83_14025	COG0217	transcriptional regulatory protein
M2J83_14030	COG0151	Belongs to the GarS family
M2J83_14040	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
M2J83_14045	COG0799	negative regulation of ribosome biogenesis
M2J83_14050	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
M2J83_14055	COG0424	maF-like protein
M2J83_14075	COG0023	Translation Initiation Factor
M2J83_14085	COG2084	Dehydrogenase
M2J83_14090	COG0625	glutathione transferase activity
M2J83_14095	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
M2J83_14100	COG1047	Peptidyl-prolyl cis-trans
M2J83_14105	COG2003	Belongs to the UPF0758 family
M2J83_14110	COG1737	Transcriptional regulator
M2J83_14115	COG0477	Major facilitator Superfamily
M2J83_14125	COG2271	Major facilitator Superfamily
M2J83_14140	COG0534	Mate efflux family protein
M2J83_14145	COG4175	Glycine betaine
M2J83_14150	COG4176	ABC-type proline glycine betaine transport system permease component
M2J83_14160	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
M2J83_14165	COG2814	Major facilitator Superfamily
M2J83_14170	COG0227	Belongs to the bacterial ribosomal protein bL28 family
M2J83_14175	COG0267	Belongs to the bacterial ribosomal protein bL33 family
M2J83_14180	COG0495	leucyl-tRNA aminoacylation
M2J83_14190	COG1466	dna polymerase III delta subunit
M2J83_14195	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
M2J83_14200	COG1981	membrane
M2J83_14215	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
M2J83_14225	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
M2J83_14230	COG0148	phosphopyruvate hydratase activity
M2J83_14240	COG2814	Major facilitator Superfamily
M2J83_14255	COG2877	3-deoxy-8-phosphooctulonate synthase activity
M2J83_14265	COG0504	CTP synthase activity
M2J83_14300	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
M2J83_14310	COG0791	NLP P60 protein
M2J83_14320	COG0583	DNA-binding transcription factor activity
M2J83_14330	COG0583	DNA-binding transcription factor activity
M2J83_14340	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
M2J83_14355	COG1045	serine acetyltransferase
M2J83_14370	COG1381	Involved in DNA repair and RecF pathway recombination
M2J83_14375	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
M2J83_14380	COG0571	ribonuclease III activity
M2J83_14395	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
M2J83_14415	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
M2J83_14420	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M2J83_14425	COG1028	Short-chain dehydrogenase reductase Sdr
M2J83_14430	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
M2J83_14435	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
M2J83_14445	COG0333	Belongs to the bacterial ribosomal protein bL32 family
M2J83_14450	COG1399	metal-binding, possibly nucleic acid-binding protein
M2J83_14455	COG0424	maF-like protein
M2J83_14465	COG3023	N-Acetylmuramoyl-L-alanine amidase
M2J83_14470	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
M2J83_14475	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
M2J83_14480	COG0546	phosphoglycolate phosphatase activity
M2J83_14485	COG0564	pseudouridine synthase activity
M2J83_14490	COG1530	ribonuclease E activity
M2J83_14495	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
M2J83_14500	COG0159	tryptophan synthase activity
M2J83_14505	COG0133	tryptophan synthase activity
M2J83_14510	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
M2J83_14520	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
M2J83_14525	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
M2J83_14535	COG2878	Part of a membrane complex involved in electron transport
M2J83_14540	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
M2J83_14545	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
M2J83_14550	COG3047	cAMP biosynthetic process
M2J83_14575	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
M2J83_14580	COG2917	probably involved in intracellular septation
M2J83_14590	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
M2J83_14595	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
M2J83_14605	COG1196	nuclear chromosome segregation
M2J83_14615	COG1573	uracil-dna glycosylase
M2J83_14620	COG1214	PFAM Peptidase M22, glycoprotease
M2J83_14635	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
M2J83_14640	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
M2J83_14645	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
M2J83_14650	COG0560	Phosphoserine phosphatase
M2J83_14665	COG1007	ATP synthesis coupled electron transport
M2J83_14680	COG0713	ATP synthesis coupled electron transport
M2J83_14690	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
M2J83_14695	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
M2J83_14700	COG1034	ATP synthesis coupled electron transport
M2J83_14715	COG0649	NAD binding
M2J83_14720	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
M2J83_14725	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
M2J83_14730	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
M2J83_14735	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
M2J83_14750	COG0149	triose-phosphate isomerase activity
M2J83_14755	COG0604	alcohol dehydrogenase
M2J83_14775	COG1185	polyribonucleotide nucleotidyltransferase activity
M2J83_14780	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
M2J83_14785	COG1183	phosphatidylcholine synthase activity
M2J83_14790	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
M2J83_14795	COG0440	acetolactate synthase activity
M2J83_14800	COG0028	Belongs to the TPP enzyme family
M2J83_14805	COG1289	transmembrane transporter activity
M2J83_14810	COG3022	response to hydroperoxide
M2J83_14815	COG1028	Short-chain dehydrogenase reductase Sdr
M2J83_14835	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
M2J83_14840	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
M2J83_14845	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
M2J83_14850	COG1674	ftsk spoiiie
M2J83_14855	COG0492	ferredoxin-NADP+ reductase activity
M2J83_14875	COG0477	Major facilitator Superfamily
M2J83_14895	COG2272	Belongs to the type-B carboxylesterase lipase family
M2J83_14900	COG1960	acyl-CoA dehydrogenase activity
M2J83_14925	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
M2J83_14945	COG2204	response regulator
M2J83_14985	COG4964	Belongs to the GSP D family
M2J83_15040	COG0612	Peptidase, M16
M2J83_15045	COG0484	heat shock protein binding
M2J83_15050	COG0443	Heat shock 70 kDa protein
M2J83_15055	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
M2J83_15060	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
M2J83_15065	COG1420	regulation of RNA biosynthetic process
M2J83_15075	COG0497	DNA recombination
M2J83_15080	COG0735	belongs to the Fur family
M2J83_15085	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
M2J83_15090	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
M2J83_15115	COG0477	Major facilitator Superfamily
M2J83_15125	COG0812	UDP-N-acetylmuramate dehydrogenase activity
M2J83_15145	COG0582	viral genome integration into host DNA
M2J83_15155	COG1396	sequence-specific DNA binding
M2J83_15160	COG0583	DNA-binding transcription factor activity
M2J83_15180	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
M2J83_15185	COG0633	Ferredoxin
M2J83_15190	COG0789	Transcriptional regulator
M2J83_15200	COG0640	Transcriptional regulator
M2J83_15205	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M2J83_15235	COG1937	Protein conserved in bacteria
M2J83_15240	COG2814	Major facilitator Superfamily
M2J83_15245	COG1230	cation diffusion facilitator family transporter
M2J83_15250	COG0640	Transcriptional regulator
M2J83_15260	COG2217	Heavy metal translocating P-type atpase
M2J83_15285	COG2814	Major facilitator Superfamily
M2J83_15300	COG2814	Major facilitator Superfamily
M2J83_15315	COG2186	Transcriptional regulator
M2J83_15335	COG2877	3-deoxy-8-phosphooctulonate synthase activity
M2J83_15385	COG2003	Belongs to the UPF0758 family
M2J83_15565	COG0789	Transcriptional regulator
M2J83_15605	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
M2J83_15615	COG0789	Transcriptional regulator
M2J83_15635	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
M2J83_15640	COG0629	single-stranded DNA binding
M2J83_15705	COG1538	Outer membrane efflux protein
M2J83_15735	COG2814	Major facilitator Superfamily
M2J83_15745	COG2819	hydrolase of the alpha beta superfamily
M2J83_15765	COG1454	alcohol dehydrogenase
M2J83_15775	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
M2J83_15800	COG1414	Transcriptional regulator
M2J83_15805	COG0513	Belongs to the DEAD box helicase family
M2J83_15815	COG0583	DNA-binding transcription factor activity
M2J83_15820	COG4638	Rieske (2fe-2S)
M2J83_15825	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
M2J83_15840	COG0446	pyridine nucleotide-disulphide oxidoreductase
M2J83_15855	COG3971	2-oxopent-4-enoate hydratase activity
M2J83_15860	COG4569	acetaldehyde dehydrogenase (acetylating) activity
M2J83_15865	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
M2J83_15870	COG2814	Major facilitator Superfamily
M2J83_15885	COG0154	amidase activity
M2J83_15890	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M2J83_15895	COG2814	Major facilitator Superfamily
M2J83_15930	COG1028	Short-chain dehydrogenase reductase Sdr
M2J83_15940	COG0842	Transport permease protein
M2J83_15945	COG0842	Transport permease protein
M2J83_15945	COG1129	ABC transporter
M2J83_15950	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M2J83_15960	COG3243	poly(R)-hydroxyalkanoic acid synthase
M2J83_15970	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
M2J83_15975	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
M2J83_15980	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
M2J83_15995	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
M2J83_16010	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
M2J83_16015	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
M2J83_16025	COG0789	Transcriptional regulator
M2J83_16035	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
M2J83_16080	COG3278	Belongs to the heme-copper respiratory oxidase family
M2J83_16085	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M2J83_16105	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
M2J83_16150	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
M2J83_16215	COG0517	IMP dehydrogenase activity
M2J83_16215	COG0516	GMP reductase activity
M2J83_16225	COG1027	Aspartate ammonia-lyase
M2J83_16230	COG1846	Transcriptional regulator
M2J83_16245	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
M2J83_16250	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
M2J83_16265	COG1414	Transcriptional regulator
M2J83_16285	COG0513	Belongs to the DEAD box helicase family
M2J83_16305	COG0429	hydrolase of the alpha beta-hydrolase fold
M2J83_16330	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M2J83_16340	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
M2J83_16350	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
M2J83_16355	COG0632	four-way junction helicase activity
M2J83_16365	COG2255	four-way junction helicase activity
M2J83_16375	COG0418	dihydroorotase activity
M2J83_16385	COG0415	Belongs to the DNA photolyase family
M2J83_16450	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
M2J83_16455	COG4654	Cytochrome c, class I
M2J83_16490	COG1177	transmembrane transport
M2J83_16495	COG3842	ATPase activity
M2J83_16500	COG1840	ABC-type Fe3 transport system, periplasmic component
M2J83_16505	COG2084	Dehydrogenase
M2J83_16520	COG0494	nUDIX hydrolase
M2J83_16525	COG0442	prolyl-tRNA aminoacylation
M2J83_16530	COG0824	Thioesterase
M2J83_16535	COG0811	peptide transport
M2J83_16550	COG0823	Involved in the tonB-independent uptake of proteins
M2J83_16565	COG0596	Alpha beta hydrolase
M2J83_16590	COG1079	Belongs to the binding-protein-dependent transport system permease family
M2J83_16595	COG4603	Belongs to the binding-protein-dependent transport system permease family
M2J83_16600	COG3845	ABC transporter
M2J83_16620	COG0427	acetyl-CoA hydrolase
M2J83_16625	COG0583	DNA-binding transcription factor activity
M2J83_16630	COG3634	alkyl hydroperoxide reductase activity
M2J83_16645	COG0697	spore germination
M2J83_16650	COG0175	sulfate reduction
M2J83_16660	COG2895	sulfate adenylyltransferase (ATP) activity
M2J83_16670	COG1012	belongs to the aldehyde dehydrogenase family
M2J83_16675	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M2J83_16680	COG5383	Protein conserved in bacteria
M2J83_16690	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
M2J83_16705	COG0583	DNA-binding transcription factor activity
M2J83_16710	COG1741	Belongs to the pirin family
M2J83_16715	COG3706	GGDEF domain
M2J83_16720	COG0154	amidase activity
M2J83_16735	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
M2J83_16745	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
M2J83_16750	COG0284	orotidine-5'-phosphate decarboxylase activity
M2J83_16765	COG1414	Transcriptional regulator
M2J83_16775	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
M2J83_16785	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
M2J83_16790	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
M2J83_16815	COG0742	ribosomal rna small subunit methyltransferase
M2J83_16820	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
M2J83_16825	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
M2J83_16855	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
M2J83_16870	COG1335	isochorismatase
M2J83_16875	COG2309	aminopeptidase activity
M2J83_16880	COG0596	Alpha beta hydrolase
M2J83_16885	COG1529	Aldehyde oxidase and xanthine dehydrogenase
M2J83_16885	COG2010	Cytochrome c
M2J83_16890	COG2080	2 iron, 2 sulfur cluster binding
M2J83_16895	COG2010	Cytochrome c
M2J83_16895	COG1529	Aldehyde oxidase and xanthine dehydrogenase
M2J83_16910	COG0411	ABC transporter
M2J83_16935	COG3706	GGDEF domain
M2J83_16950	COG3181	Tripartite tricarboxylate transporter family receptor
M2J83_16960	COG1234	tRNA 3'-trailer cleavage
M2J83_16965	COG2188	Transcriptional regulator
M2J83_16975	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
M2J83_16985	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
M2J83_16985	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
M2J83_16990	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
M2J83_16990	COG3608	succinylglutamate desuccinylase aspartoacylase
M2J83_16995	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
M2J83_17005	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
M2J83_17035	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
M2J83_17060	COG1335	isochorismatase
M2J83_17065	COG2309	aminopeptidase activity
M2J83_17070	COG0596	Alpha beta hydrolase
M2J83_17085	COG1120	ATPase activity
M2J83_17090	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M2J83_17100	COG4206	TonB-dependent receptor
M2J83_17105	COG2031	fatty acid transporter
M2J83_17110	COG0583	DNA-binding transcription factor activity
M2J83_17115	COG0402	S-adenosylhomocysteine deaminase activity
M2J83_17120	COG3181	Tripartite tricarboxylate transporter family receptor
M2J83_17135	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
M2J83_17140	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M2J83_17145	COG0328	RNA-DNA hybrid ribonuclease activity
M2J83_17150	COG2226	methyltransferase
M2J83_17155	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M2J83_17160	COG0741	lytic transglycosylase activity
M2J83_17160	COG1388	LysM domain
M2J83_17180	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
M2J83_17205	COG2204	response regulator
M2J83_17210	COG4191	Histidine kinase
M2J83_17215	COG1301	dicarboxylic acid transport
M2J83_17225	COG1054	Belongs to the UPF0176 family
M2J83_17250	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
M2J83_17270	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
M2J83_17285	COG1028	Short-chain dehydrogenase reductase Sdr
M2J83_17290	COG1877	trehalose-phosphatase activity
M2J83_17325	COG0604	alcohol dehydrogenase
M2J83_17335	COG1024	Enoyl-CoA hydratase
M2J83_17355	COG1902	pentaerythritol trinitrate reductase activity
M2J83_17380	COG0583	DNA-binding transcription factor activity
M2J83_17400	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
M2J83_17405	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
M2J83_17410	COG0583	DNA-binding transcription factor activity
M2J83_17435	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M2J83_17450	COG1393	Belongs to the ArsC family
M2J83_17455	COG0431	NADPH-dependent FMN reductase
M2J83_17460	COG0745	RESPONSE REGULATOR receiver
M2J83_17465	COG0642	Histidine kinase
M2J83_17545	COG2948	multi-organism process
M2J83_17580	COG0433	COG0433 Predicted ATPase
M2J83_17655	COG0582	viral genome integration into host DNA
M2J83_17665	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
M2J83_17665	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
M2J83_17670	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
M2J83_17675	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
M2J83_17680	COG1881	PFAM PEBP family protein
M2J83_17685	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
M2J83_17690	COG0739	heme binding
M2J83_17695	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
M2J83_17700	COG0316	Belongs to the HesB IscA family
M2J83_17710	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
M2J83_17715	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
M2J83_17720	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
M2J83_17725	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
M2J83_17730	COG0312	modulator of DNA gyrase
M2J83_17735	COG3028	Belongs to the UPF0307 family
M2J83_17765	COG4566	intracellular signal transduction
M2J83_17770	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
M2J83_17775	COG0402	S-adenosylhomocysteine deaminase activity
M2J83_17780	COG2233	PERMEase
M2J83_17785	COG0596	Alpha beta hydrolase
M2J83_17785	COG2945	thiolester hydrolase activity
M2J83_17795	COG1028	Short-chain dehydrogenase reductase Sdr
M2J83_17805	COG0583	DNA-binding transcription factor activity
M2J83_17810	COG4681	YaeQ
M2J83_17835	COG0762	integral membrane protein
M2J83_17845	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
M2J83_17845	COG2169	Transcriptional regulator
M2J83_17855	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M2J83_17870	COG0439	Biotin carboxylase
M2J83_17875	COG0511	ligase activity, forming carbon-carbon bonds
M2J83_17880	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
M2J83_17885	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M2J83_17890	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
M2J83_17895	COG3150	esterase
M2J83_17910	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
M2J83_17915	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
M2J83_17925	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
M2J83_17940	COG1678	Uncharacterized ACR, COG1678
M2J83_17955	COG0352	thiamine-phosphate diphosphorylase activity
M2J83_17960	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
M2J83_17975	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
M2J83_17985	COG3237	CsbD-like
M2J83_17990	COG0261	This protein binds to 23S rRNA in the presence of protein L20
M2J83_17995	COG0211	Belongs to the bacterial ribosomal protein bL27 family
M2J83_18000	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
M2J83_18005	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
M2J83_18030	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
M2J83_18045	COG1126	abc transporter atp-binding protein
M2J83_18050	COG0765	amino acid transport
M2J83_18055	COG4597	amino acid ABC transporter
M2J83_18060	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M2J83_18065	COG2884	Cell division ATP-binding protein ftsE
M2J83_18070	COG2177	Part of the ABC transporter FtsEX involved in
M2J83_18075	COG1194	a g-specific adenine glycosylase
M2J83_18080	COG0772	Belongs to the SEDS family
M2J83_18085	COG0768	penicillin binding
M2J83_18095	COG1792	Involved in formation and maintenance of cell shape
M2J83_18100	COG1077	Cell shape determining protein MreB Mrl
M2J83_18105	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
M2J83_18110	COG0154	amidase activity
M2J83_18115	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
M2J83_18120	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
M2J83_18125	COG0583	DNA-binding transcription factor activity
M2J83_18130	COG2259	Doxx family
M2J83_18135	COG3384	dioxygenase
M2J83_18145	COG3245	cytochrome
M2J83_18160	COG3604	Transcriptional regulator
M2J83_18175	COG0786	glutamate:sodium symporter activity
M2J83_18180	COG0142	geranyltranstransferase activity
M2J83_18190	COG0494	nUDIX hydrolase
M2J83_18195	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
M2J83_18220	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
M2J83_18225	COG0237	dephospho-CoA kinase activity
M2J83_18240	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
M2J83_18245	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
M2J83_18255	COG0477	Major facilitator Superfamily
M2J83_18260	COG0259	pyridoxamine-phosphate oxidase activity
M2J83_18275	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
M2J83_18310	COG4206	TonB-dependent receptor
M2J83_18315	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
M2J83_18325	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
M2J83_18345	COG0598	Magnesium transport protein CorA
M2J83_18360	COG2022	thiamine diphosphate biosynthetic process
M2J83_18365	COG0351	phosphomethylpyrimidine kinase
M2J83_18370	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
M2J83_18375	COG3344	reverse transcriptase
M2J83_18380	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
M2J83_18385	COG1538	Outer membrane efflux protein
M2J83_18390	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
M2J83_18400	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
M2J83_18415	COG2226	methyltransferase
M2J83_18420	COG0745	RESPONSE REGULATOR receiver
M2J83_18435	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
M2J83_18440	COG1984	allophanate hydrolase subunit 2
M2J83_18445	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
M2J83_18450	COG1238	metal cluster binding
M2J83_18475	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
M2J83_18480	COG4988	ABC transporter
M2J83_18490	COG1294	oxidase, subunit
M2J83_18495	COG1271	oxidase subunit
M2J83_18510	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
M2J83_18525	COG1137	ATPase activity
M2J83_18535	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
M2J83_18540	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
M2J83_18545	COG1660	Displays ATPase and GTPase activities
M2J83_18555	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
M2J83_18560	COG0792	nuclease activity
M2J83_18565	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
M2J83_18580	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
M2J83_18600	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
M2J83_18605	COG0793	Belongs to the peptidase S41A family
M2J83_18615	COG0588	phosphoglycerate mutase activity
M2J83_18620	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
M2J83_18630	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
M2J83_18635	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
M2J83_18640	COG3181	Tripartite tricarboxylate transporter family receptor
M2J83_18645	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
M2J83_18650	COG1040	competence protein
M2J83_18655	COG2226	methyltransferase
M2J83_18660	COG4771	TonB-dependent receptor
M2J83_18665	COG0745	RESPONSE REGULATOR receiver
M2J83_18675	COG2205	protein histidine kinase activity
M2J83_18685	COG2204	response regulator
M2J83_18705	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
M2J83_18715	COG3473	Maleate cis-trans isomerase
M2J83_18730	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
M2J83_18760	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
M2J83_18760	COG0662	Cupin 2, conserved barrel domain protein
M2J83_18765	COG1215	transferase activity, transferring glycosyl groups
M2J83_18775	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
M2J83_18790	COG1088	dTDP-glucose 4,6-dehydratase activity
M2J83_18795	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
M2J83_18810	COG0355	proton-transporting ATP synthase activity, rotational mechanism
M2J83_18820	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
M2J83_18825	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
M2J83_18830	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
M2J83_18845	COG0356	it plays a direct role in the translocation of protons across the membrane
M2J83_18855	COG1024	Enoyl-CoA hydratase
M2J83_18870	COG0037	tRNA processing
M2J83_18875	COG0163	prenyltransferase activity
M2J83_18880	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
M2J83_18885	COG2890	protein-(glutamine-N5) methyltransferase activity
M2J83_18935	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
M2J83_18965	COG0811	peptide transport
M2J83_18980	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
M2J83_18985	COG2264	protein methyltransferase activity
M2J83_18990	COG4773	Receptor
M2J83_19010	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
M2J83_19035	COG3180	Ammonia monooxygenase
M2J83_19055	COG5002	protein histidine kinase activity
M2J83_19070	COG0477	Major facilitator Superfamily
M2J83_19075	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
M2J83_19095	COG1116	anion transmembrane transporter activity
M2J83_19125	COG0437	4 iron, 4 sulfur cluster binding
M2J83_19130	COG2864	formate dehydrogenase
M2J83_19140	COG1921	L-seryl-tRNASec selenium transferase activity
M2J83_19145	COG3276	selenocysteine insertion sequence binding
M2J83_19155	COG1476	TRANSCRIPTIONal
M2J83_19170	COG3181	Tripartite tricarboxylate transporter family receptor
M2J83_19190	COG0709	Synthesizes selenophosphate from selenide and ATP
M2J83_19205	COG0583	DNA-binding transcription factor activity
M2J83_19210	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
M2J83_19215	COG0348	domain, Protein
M2J83_19215	COG3901	Regulator of nitric oxide reductase transcription
M2J83_19220	COG4263	nitrous-oxide reductase activity
M2J83_19235	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
M2J83_19250	COG0166	Belongs to the GPI family
M2J83_19265	COG1215	transferase activity, transferring glycosyl groups
M2J83_19300	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
M2J83_19335	COG0156	8-amino-7-oxononanoate synthase activity
M2J83_19340	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M2J83_19345	COG1028	Short-chain dehydrogenase reductase Sdr
M2J83_19345	COG3321	synthase
M2J83_19345	COG0604	alcohol dehydrogenase
M2J83_19350	COG2233	PERMEase
M2J83_19355	COG0697	spore germination
M2J83_19360	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M2J83_19365	COG0697	spore germination
M2J83_19385	COG2885	chlorophyll binding
M2J83_19480	COG0183	Belongs to the thiolase family
M2J83_19485	COG1250	3-hydroxyacyl-CoA dehydrogenase
M2J83_19485	COG1024	Enoyl-CoA hydratase
M2J83_19500	COG1127	ABC transporter
M2J83_19505	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
M2J83_19510	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
M2J83_19525	COG1131	(ABC) transporter
M2J83_19530	COG0842	Transport permease protein
M2J83_19540	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
M2J83_19550	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
M2J83_19555	COG0131	Imidazoleglycerol-phosphate dehydratase
M2J83_19565	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
M2J83_19570	COG0107	imidazoleglycerol-phosphate synthase activity
M2J83_19580	COG0140	phosphoribosyl-ATP diphosphatase activity
M2J83_19585	COG0537	adenosine 5'-monophosphoramidase activity
M2J83_19590	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
M2J83_19595	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
M2J83_19605	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
M2J83_19615	COG1970	mechanosensitive ion channel activity
M2J83_19620	COG0723	plastoquinol--plastocyanin reductase activity
M2J83_19625	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
M2J83_19630	COG2857	Cytochrome c1
M2J83_19635	COG0625	glutathione transferase activity
M2J83_19640	COG2969	positive regulation of protein catabolic process
M2J83_19645	COG4208	sulfate ABC transporter
M2J83_19650	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
M2J83_19655	COG4150	thiosulfate binding
M2J83_19680	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
M2J83_19700	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
M2J83_19705	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M2J83_19720	COG0129	dihydroxy-acid dehydratase activity
M2J83_19725	COG1802	Transcriptional regulator
M2J83_19730	COG1522	sequence-specific DNA binding
M2J83_19740	COG3483	tryptophan 2,3-dioxygenase activity
M2J83_19760	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
M2J83_19765	COG0656	L-ascorbic acid biosynthetic process
M2J83_19775	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
M2J83_19780	COG3706	GGDEF domain
M2J83_19785	COG2226	methyltransferase
M2J83_19795	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
M2J83_19810	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
M2J83_19815	COG0583	DNA-binding transcription factor activity
M2J83_19820	COG0477	Major facilitator Superfamily
M2J83_19825	COG1028	Short-chain dehydrogenase reductase Sdr
M2J83_19835	COG1335	isochorismatase
M2J83_19840	COG1335	isochorismatase
M2J83_19860	COG2823	Periplasmic or secreted lipoprotein
M2J83_19870	COG3284	Transcriptional regulator
M2J83_19900	COG1595	DNA-templated transcription, initiation
M2J83_19920	COG1285	pathogenesis
M2J83_19935	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
M2J83_20005	COG1522	sequence-specific DNA binding
M2J83_20015	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
M2J83_20035	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
M2J83_20075	COG0109	protoheme IX farnesyltransferase activity
M2J83_20095	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
M2J83_20115	COG3568	Endonuclease Exonuclease Phosphatase
M2J83_20120	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
M2J83_20145	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M2J83_20155	COG1228	amidohydrolase
M2J83_20165	COG2986	histidine ammonia-lyase
M2J83_20170	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
M2J83_20200	COG2814	Major facilitator Superfamily
M2J83_20210	COG0789	Transcriptional regulator
M2J83_20230	COG0625	glutathione transferase activity
M2J83_20260	COG2365	Tyrosine phosphatase family
M2J83_20265	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
M2J83_20285	COG2423	ornithine cyclodeaminase activity
M2J83_20335	COG3069	C4-dicarboxylate transmembrane transporter activity
M2J83_20345	COG1802	Transcriptional regulator
M2J83_20355	COG2814	Major facilitator Superfamily
M2J83_20370	COG2814	Major facilitator Superfamily
M2J83_20375	COG0251	oxidation-reduction process
M2J83_20380	COG3181	Tripartite tricarboxylate transporter family receptor
M2J83_20385	COG0179	Fumarylacetoacetate (FAA) hydrolase
M2J83_20390	COG2186	Transcriptional regulator
M2J83_20400	COG2814	Major facilitator Superfamily
M2J83_20410	COG0232	Belongs to the dGTPase family. Type 2 subfamily
M2J83_20415	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
M2J83_20420	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
M2J83_20440	COG5001	Diguanylate cyclase
M2J83_20440	COG5002	protein histidine kinase activity
M2J83_20445	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
M2J83_20450	COG1333	cytochrome c biogenesis protein
M2J83_20460	COG0218	Necessary for normal cell division and for the maintenance of normal septation
M2J83_20465	COG0113	porphobilinogen synthase activity
M2J83_20470	COG4232	protein-disulfide reductase activity
M2J83_20490	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M2J83_20495	COG0203	ribosomal protein L17
M2J83_20500	COG0202	RNA polymerase activity
M2J83_20505	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
M2J83_20510	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
M2J83_20515	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
M2J83_20520	COG0257	Belongs to the bacterial ribosomal protein bL36 family
M2J83_20530	COG0201	protein transport
M2J83_20535	COG0200	Binds to the 23S rRNA
M2J83_20540	COG1841	ribosomal large subunit assembly
M2J83_20545	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
M2J83_20550	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
M2J83_20555	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
M2J83_20560	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
M2J83_20565	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
M2J83_20570	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
M2J83_20575	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
M2J83_20580	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
M2J83_20635	COG1538	Outer membrane efflux protein
M2J83_20655	COG0183	Belongs to the thiolase family
M2J83_20665	COG2067	long-chain fatty acid transport protein
M2J83_20680	COG0318	PFAM AMP-dependent synthetase and ligase
M2J83_20685	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
M2J83_20690	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
M2J83_20695	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
M2J83_20695	COG1648	precorrin-2 dehydrogenase activity
M2J83_20710	COG1116	anion transmembrane transporter activity
M2J83_20715	COG1960	acyl-CoA dehydrogenase activity
M2J83_20730	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
M2J83_20735	COG0255	Belongs to the universal ribosomal protein uL29 family
M2J83_20740	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
M2J83_20745	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
M2J83_20750	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
M2J83_20755	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
M2J83_20760	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
M2J83_20765	COG0089	rRNA binding
M2J83_20770	COG0088	Forms part of the polypeptide exit tunnel
M2J83_20775	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
M2J83_20780	COG4175	Glycine betaine
M2J83_20785	COG4176	ABC-type proline glycine betaine transport system permease component
M2J83_20790	COG0051	transcription antitermination factor activity, RNA binding
M2J83_20795	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
M2J83_20800	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
M2J83_20805	COG0049	tRNA binding
M2J83_20810	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
M2J83_20840	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
M2J83_20845	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
M2J83_20850	COG0085	RNA polymerase activity
M2J83_20855	COG0222	ribosome binding
M2J83_20860	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
M2J83_20865	COG0081	regulation of translation
M2J83_20910	COG1475	DNA binding
M2J83_20915	COG1192	Involved in chromosome partitioning
M2J83_20920	COG0357	Ribosomal RNA small subunit methyltransferase G
M2J83_20925	COG0445	tRNA wobble uridine modification
M2J83_20930	COG0436	Aminotransferase
M2J83_20940	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
M2J83_20945	COG3706	GGDEF domain
M2J83_20950	COG0688	phosphatidylethanolamine metabolic process
M2J83_20960	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
M2J83_21000	COG3645	SOS response
M2J83_21010	COG3093	addiction module antidote protein HigA
M2J83_21035	COG2189	Belongs to the N(4) N(6)-methyltransferase family
M2J83_21055	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
M2J83_21070	COG0582	viral genome integration into host DNA
M2J83_21075	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
M2J83_21110	COG0753	catalase activity
M2J83_21115	COG0706	membrane insertase activity
M2J83_21120	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
M2J83_21125	COG0594	ribonuclease P activity
M2J83_21130	COG0230	Belongs to the bacterial ribosomal protein bL34 family
M2J83_21225	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
M2J83_21240	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
M2J83_21245	COG3041	Addiction module toxin RelE StbE family
M2J83_21250	COG3077	Addiction module antitoxin, RelB DinJ family
M2J83_21255	COG1192	Involved in chromosome partitioning