locus-tag class description ALFP_0002 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) ALFP_0003 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) ALFP_0004 ENOG4105I08 Pseudouridine synthase ALFP_0007 ENOG4105CG6 trap dicarboxylate transporter dctm subunit ALFP_0012 ENOG4108Z9W Outer membrane porin ALFP_0013 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) ALFP_0024 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F ALFP_0026 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F ALFP_0028 ENOG4105CG6 trap dicarboxylate transporter dctm subunit ALFP_0032 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase ALFP_0036 ENOG4105CH5 extracellular solute-binding protein, family 7 ALFP_0038 ENOG4105C32 Amino acid ABC transporter (Permease) ALFP_0039 ENOG4105CF8 branched-chain amino acid ABC transporter, permease ALFP_0040 ENOG4108IV0 ABC, transporter ALFP_0041 ENOG4105CEY Amp-dependent synthetase and ligase ALFP_0043 ENOG4107TTQ Alpha beta hydrolase fold ALFP_0044 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family ALFP_0050 ENOG4108Q5Y Membrane ALFP_0051 ENOG4105CVI Transcriptional regulator ALFP_0053 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) ALFP_0055 ENOG4105CHM Aminotransferase ALFP_0057 ENOG4105CKI cobalamin synthesis protein ALFP_0068 ENOG4108SY4 MarR family Transcriptional regulator ALFP_0072 ENOG4105ERH Fumarylacetoacetate hydrolase ALFP_0073 ENOG4105ES4 Nitrilase ALFP_0074 ENOG4106IPI cyclase, family ALFP_0075 ENOG4105E3J oxidoreductase ALFP_0076 ENOG4105FUY alpha subunit ALFP_0081 ENOG4105CHR reductase ALFP_0083 ENOG4105CG6 trap dicarboxylate transporter dctm subunit ALFP_0088 ENOG41061TZ Short-chain dehydrogenase reductase Sdr ALFP_0092 ENOG4108K3Z AraC family transcriptional regulator ALFP_0094 ENOG4108JEH abc transporter atp-binding protein ALFP_0096 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) ALFP_0097 ENOG4105CNM Receptor ALFP_0099 ENOG4108SF5 RNA Polymerase ALFP_0100 ENOG4108JQ7 (ABC) transporter ALFP_0101 ENOG4105C3U ABC transporter ALFP_0102 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component ALFP_0103 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component ALFP_0104 ENOG4105DEF Extracellular solute-binding protein, family 5 ALFP_0107 ENOG4105C8Y Acetylornithine aminotransferase ALFP_0109 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) ALFP_0110 ENOG4108UZX fmn reductase ALFP_0114 ENOG4105ETT transcriptional Regulator, LysR family ALFP_0116 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase ALFP_0117 ENOG4105E0C molybdate abc transporter ALFP_0119 ENOG4107QP3 malate synthase g ALFP_0121 ENOG4105FYV Amp nucleosidase ALFP_0123 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit ALFP_0124 ENOG4105CG6 trap dicarboxylate transporter dctm subunit ALFP_0127 ENOG4105C7K acetolactate synthase ALFP_0128 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit ALFP_0130 ENOG4105CG6 trap dicarboxylate transporter dctm subunit ALFP_0132 ENOG4105C9U ATP-dependent DNA helicase RecQ ALFP_0134 ENOG4108RPN Protein smg homolog ALFP_0137 ENOG4107QX3 carboxylase ALFP_0138 ENOG4105CHU acetyl-coa acetyltransferase ALFP_0139 ENOG4105VS7 Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation (By similarity) ALFP_0140 ENOG4105C1G acyl-Coa dehydrogenase ALFP_0144 ENOG4108Z33 Thiol disulfide Interchange Protein ALFP_0146 ENOG4105C75 arginyL-tRNA synthetase ALFP_0151 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) ALFP_0153 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) ALFP_0155 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) ALFP_0156 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) ALFP_0157 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase ALFP_0158 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F ALFP_0159 ENOG4105CG6 trap dicarboxylate transporter dctm subunit ALFP_0161 ENOG4105CH5 extracellular solute-binding protein, family 7 ALFP_0162 ENOG4108UAU isochorismatase ALFP_0163 ENOG4107R11 Transcriptional regulator ALFP_0165 ENOG4108UQY Iron-storage protein ALFP_0167 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) ALFP_0168 ENOG410829K Lysine exporter protein (Lyse ygga) ALFP_0169 ENOG4105C1J atp-dependent rna helicase ALFP_0171 ENOG4105HA9 of methanol dehydrogenase type ALFP_0174 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) ALFP_0177 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) ALFP_0181 ENOG4105CVI Transcriptional regulator ALFP_0185 ENOG4105CG6 trap dicarboxylate transporter dctm subunit ALFP_0188 ENOG4105DHJ ABC, transporter ALFP_0189 ENOG4108SNX Mammalian cell entry related domain protein ALFP_0192 ENOG4107YBY Hydrolase ALFP_0193 ENOG4108NDG TRAP dicarboxylate ALFP_0195 ENOG4105CG6 trap dicarboxylate transporter dctm subunit ALFP_0202 ENOG4105RQF LysR family Transcriptional regulator ALFP_0203 ENOG4105MWK D-amino acid dehydrogenase, small subunit ALFP_0205 ENOG4105CGY Dna recombination protein ALFP_0207 ENOG4105R48 this blockage is overcome by subsequent expression of antitoxin HigA. Overexpression causes cleavage of a number of mRNAs in a translation-dependent fashion, suggesting this is an mRNA interferase ALFP_0208 ENOG4105BZU Histidine kinase ALFP_0209 ENOG4105VSY K01512 acylphosphatase EC 3.6.1.7 ALFP_0213 ENOG4105D3G Pseudouridine synthase ALFP_0214 ENOG4105HDK L-asparaginase ALFP_0218 ENOG4108JEH abc transporter atp-binding protein ALFP_0219 ENOG4105D82 Glutamate dehydrogenase ALFP_0220 ENOG4105DFA alanine racemase domain protein ALFP_0224 ENOG4105C0Z ABC transporter ALFP_0225 ENOG4105C32 Amino acid ABC transporter (Permease) ALFP_0228 ENOG4108IV0 ABC, transporter ALFP_0230 ENOG4107QXX ABC transporter ALFP_0232 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase ALFP_0233 ENOG4105C79 DNA protecting protein DprA ALFP_0234 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) ALFP_0235 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) ALFP_0239 ENOG4105CG6 trap dicarboxylate transporter dctm subunit ALFP_0242 ENOG4105CFM UPF0317 protein ALFP_0243 ENOG4105SKE transcriptional Regulator LysR family ALFP_0244 ENOG4105D16 lipopolysaccharide heptosyltransferase i ALFP_0245 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase ALFP_0246 ENOG4105VEQ Cold shock protein ALFP_0247 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase ALFP_0249 ENOG4108194 Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) ALFP_0250 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase ALFP_0252 ENOG4105DZ1 carboxypeptidase ALFP_0253 ENOG4105F0I Aminotransferase ALFP_0254 ENOG4108Z43 UPF0250 protein ALFP_0255 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) ALFP_0256 ENOG4105E39 Enoyl-CoA hydratase ALFP_0257 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) ALFP_0259 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) ALFP_0263 ENOG4105CFP Peptidase U32 ALFP_0265 ENOG4105XPQ lipid carrier protein ALFP_0270 ENOG4105DK0 Indole-3-glycerol phosphate synthase ALFP_0271 ENOG4108I0Q anthranilate phosphoribosyltransferase ALFP_0272 ENOG4105DDQ anthranilate synthase ALFP_0274 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) ALFP_0276 ENOG4105DJV ribulose-phosphate 3-epimerase ALFP_0277 ENOG4105NWN ApaG protein ALFP_0278 ENOG4105CA3 membrane-bound lytic murein transglycosylase ALFP_0279 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family ALFP_0280 ENOG4105T95 Thiol disulfide interChange protein ALFP_0282 ENOG4105C8Q Methyl-accepting chemotaxis ALFP_0284 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase ALFP_0285 ENOG4105WQI isochorismatase ALFP_0286 ENOG4105E4F Isochorismate synthase ALFP_0289 ENOG4105C0W non-ribosomal peptide synthetase ALFP_0290 ENOG4105WQI isochorismatase ALFP_0291 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase ALFP_0293 ENOG4108IV0 ABC, transporter ALFP_0294 ENOG4105C0Z ABC transporter ALFP_0297 ENOG4105CAD extracellular ligand-binding receptor ALFP_0300 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component ALFP_0307 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) ALFP_0308 ENOG4105EHG Permease protein ALFP_0309 ENOG4105NIV Esterase ALFP_0310 ENOG4105C1J atp-dependent rna helicase ALFP_0311 ENOG4105C2C drug resistance transporter, Bcr CflA ALFP_0313 ENOG4108PTX LysR family Transcriptional regulator ALFP_0315 ENOG4105EE5 Membrane protein terC ALFP_0317 ENOG4105EUB pirin domain protein ALFP_0326 ENOG4108MTT Glutamate-rich protein grpB ALFP_0327 ENOG4105K5X acetyltransferase ALFP_0331 ENOG4107XC4 flavin reductase domain protein, FMN-binding ALFP_0335 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component ALFP_0338 ENOG4105RQF LysR family Transcriptional regulator ALFP_0339 ENOG4105EAB amino acid AbC transporter ALFP_0341 ENOG4105DRP amino acid AbC transporter ALFP_0342 ENOG4105EAD ABC transporter ALFP_0343 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) ALFP_0345 ENOG4105EQR Transposase IS116 IS110 IS902 ALFP_0346 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) ALFP_0356 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) ALFP_0357 ENOG4105C25 Primosomal protein n' ALFP_0358 ENOG4105C4R Atp-dependent dna helicase ALFP_0360 ENOG4105EQR Transposase IS116 IS110 IS902 ALFP_0364 ENOG4108D7R p-hydroxycinnamoyl CoA hydratase lyase ALFP_0366 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F ALFP_0367 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase ALFP_0369 ENOG4105MPD Cytochrome ALFP_0372 ENOG4105UGU tonB-dependent Receptor ALFP_0373 ENOG4105D9M gamma-glutamylcysteine synthetase ALFP_0376 ENOG4105DWV Homoserine O-trans-acetylase ALFP_0378 ENOG4105EYM Major Facilitator superfamily ALFP_0379 ENOG4105EN6 Membrane ALFP_0380 ENOG41067MG lrgb family ALFP_0382 ENOG4105KME endoribonuclease L-psp ALFP_0383 ENOG4105KME endoribonuclease L-psp ALFP_0394 ENOG4105EXG Transcriptional regulator ALFP_0396 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) ALFP_0399 ENOG4108WBT adenosyltransferase ALFP_0402 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) ALFP_0403 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) ALFP_0404 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters ALFP_0405 ENOG4105CKI cobalamin synthesis protein ALFP_0406 ENOG4105MYN Zinc uptake regulation protein ALFP_0407 ENOG4105DIK (ABC) transporter ALFP_0408 ENOG4105CC5 ABC transporter ALFP_0409 ENOG4105DSE periplasmic solute binding protein ALFP_0410 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) ALFP_0412 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) ALFP_0413 ENOG4105D1S lipid A biosynthesis ALFP_0415 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP ALFP_0416 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) ALFP_0417 ENOG41082T9 Membrane ALFP_0418 ENOG4105SYT Methylenetetrahydrofolate reductase ALFP_0420 ENOG4107SC1 transglycosylase ALFP_0424 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) ALFP_0425 ENOG4108VCT Sulfite exporter TauE/SafE ALFP_0426 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) ALFP_0427 ENOG4105C01 Dihydroxy-acid dehydratase ALFP_0428 ENOG4107RA1 nh(3)-dependent nad( ) synthetase ALFP_0434 ENOG4105IPI Membrane ALFP_0451 ENOG4105C0D helicase ALFP_0455 ENOG4107QMH DNA methylase ALFP_0456 ENOG4105DFS Conserved Protein ALFP_0457 ENOG4105D8D Type III ALFP_0459 ENOG4108Z9W Outer membrane porin ALFP_0462 ENOG4108KEZ Dehydrogenase ALFP_0464 ENOG4108IG5 Transcriptional regulator ALFP_0467 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase ALFP_0470 ENOG4105D2S major facilitator superfamily ALFP_0472 ENOG4105CV8 reductase ALFP_0473 ENOG4105F27 Major Facilitator ALFP_0474 ENOG4105HEI LysR family (Transcriptional regulator ALFP_0476 ENOG4108N8X transition metal ion binding ALFP_0481 ENOG4105GVJ transcriptional regulator ALFP_0486 ENOG4108IPW abc transporter atp-binding protein ALFP_0492 ENOG4105CXG d-lactate dehydrogenase ALFP_0494 ENOG41073TP transcriptional regulator ALFP_0495 ENOG4105DAA L-lactate ALFP_0498 ENOG4105CZE histidine utilization repressor ALFP_0499 ENOG4105F7P transcriptional regulator AsnC family ALFP_0500 ENOG4105CKY Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively (By similarity) ALFP_0501 ENOG4105C85 amino acid ALFP_0508 ENOG4105E98 transcriptional regulator DeoR family ALFP_0509 ENOG4108IJ9 (ABC) transporter ALFP_0510 ENOG4105BZ7 extracellular solute-binding protein family 1 ALFP_0512 ENOG4105DRS transport system, permease ALFP_0517 ENOG4108ZCF integral membrane protein ALFP_0518 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) ALFP_0520 ENOG4108UPT UPF0178 protein ALFP_0522 ENOG4105EST Metal Dependent Phosphohydrolase ALFP_0524 ENOG4105CXK mandelate racemase muconate lactonizing ALFP_0525 ENOG4105VEJ Heat shock protein ALFP_0526 ENOG4105C57 major facilitator superfamily ALFP_0527 ENOG41064MX Tetr family transcriptional regulator ALFP_0529 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) ALFP_0531 ENOG4107RSM transcriptional regulator ALFP_0536 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) ALFP_0537 ENOG4108ESX Receptor ALFP_0538 ENOG4107E2E PKHD-type hydroxylase ALFP_0543 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY ALFP_0544 ENOG4109066 lysm domain bon superfamily protein ALFP_0545 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) ALFP_0547 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) ALFP_0551 ENOG4105WQI isochorismatase ALFP_0557 ENOG4105CBN LysR family transcriptional regulator ALFP_0558 ENOG4105EWV Sodium calcium exchanger membrane region ALFP_0559 ENOG4105BZU Histidine kinase ALFP_0561 ENOG4105CSH Transporter ALFP_0562 ENOG4108S8N class II Aldolase ALFP_0564 ENOG4108NS2 receptor ALFP_0565 ENOG4107Y2X deaminase ALFP_0566 ENOG4105S0E allantoin catabolism protein ALFP_0567 ENOG4108M0I Transcriptional regulator ALFP_0569 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) ALFP_0571 ENOG4105D1F ATP-binding protein ALFP_0574 ENOG4105DHP deoxycytidine triphosphate deaminase ALFP_0575 ENOG4105CXN decarboxylase ALFP_0576 ENOG4105CBX hi0933 family ALFP_0577 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) ALFP_0579 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) ALFP_0580 ENOG4108UKZ OsmC family ALFP_0581 ENOG4105EUH cytochrome C oxidase, cbb3-type, subunit i ALFP_0586 ENOG4108S0N Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol (By similarity) ALFP_0587 ENOG4105CA9 Pyruvate kinase ALFP_0588 ENOG4108ZJF Glcg protein ALFP_0590 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase ALFP_0591 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) ALFP_0592 ENOG41060W2 glyoxylate carboligase ALFP_0593 ENOG4105EJC lysr family transcriptional regulator ALFP_0595 ENOG4105C2W permease ALFP_0596 ENOG41084KP 4-oxalocrotonate tautomerase ALFP_0597 ENOG4105MP9 class II Aldolase ALFP_0599 ENOG4105FFA Catalyzes the oxidation of uric acid to 5- hydroxyisourate, which is further processed to form (S)-allantoin (By similarity) ALFP_0601 ENOG4107UKG Glycosyl transferase, family 4 ALFP_0602 ENOG4107QQG Dehydrogenase ALFP_0605 ENOG4105CG5 Glycosyl transferase (Group 1 ALFP_0606 ENOG4107XU6 Glycosyl transferase (Group 1 ALFP_0607 ENOG4105CGN Glycosyl transferase (Group 1 ALFP_0609 ENOG4105CQB FAD linked oxidase domain protein ALFP_0611 ENOG4105ERH Fumarylacetoacetate hydrolase ALFP_0612 ENOG4105F1J Homogentisate 1,2-dioxygenase ALFP_0614 ENOG4105E2Q 3-(3-hydroxy-phenyl)propionate hydroxylase ALFP_0616 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) ALFP_0618 ENOG41081V9 Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein (By similarity) ALFP_0620 ENOG4105C5T Phosphoribosyl pyrophosphate synthase ALFP_0621 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) ALFP_0622 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) ALFP_0624 ENOG4105C3G gtp-binding protein ALFP_0629 ENOG4108594 Permease of the drug metabolite transporter ALFP_0630 ENOG4106JUT Streptomycin 3''-adenylyltransferase ALFP_0631 ENOG4105C5H ABC transporter ALFP_0634 ENOG4107B2H carbonic anhydrase ALFP_0635 ENOG4105DND Transcriptional regulator ALFP_0637 ENOG4107EV4 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity) ALFP_0638 ENOG4105CA5 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity) ALFP_0639 ENOG41060IM Heme exporter protein ALFP_0641 ENOG4108ZKK Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH (By similarity) ALFP_0642 ENOG4105DA4 cytochrome c-type biogenesis protein ALFP_0643 ENOG4107QX9 Thiol disulfide interChange protein ALFP_0644 ENOG4105KWW Biogenesis protein ALFP_0645 ENOG4108M1T Cytochrome c-type biogenesis protein ALFP_0646 ENOG4107QIV Cytochrome c biogenesis protein ALFP_0648 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) ALFP_0652 ENOG4105C32 Amino acid ABC transporter (Permease) ALFP_0653 ENOG4105CF8 branched-chain amino acid ABC transporter, permease ALFP_0654 ENOG4105C0Z ABC transporter ALFP_0655 ENOG4108IV0 ABC, transporter ALFP_0656 ENOG4105CA0 peroxidase ALFP_0657 ENOG4108JQ1 Dehydrogenase ALFP_0658 ENOG4105KPV Transcriptional regulator ALFP_0659 ENOG4105VIG Sec-independent protein translocase protein TatC ALFP_0668 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) ALFP_0669 ENOG4108IEG Formate dehydrogenase Alpha subunit ALFP_0670 ENOG4107QIZ NADH dehydrogenase ALFP_0672 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family ALFP_0673 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) ALFP_0674 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) ALFP_0675 ENOG4105CVM Molybdenum cofactor synthesis domain protein ALFP_0676 ENOG4108RIR Molybdenum cofactor biosynthesis protein ALFP_0677 ENOG4108ZAF Molybdopterin ALFP_0679 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) ALFP_0680 ENOG4108ZXC Two component transcriptional regulator, luxr family ALFP_0681 ENOG4105BZU Histidine kinase ALFP_0682 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit ALFP_0683 ENOG4108RA0 tripartite ATP-independent periplasmic transporter, DctQ component ALFP_0684 ENOG4105CG6 trap dicarboxylate transporter dctm subunit ALFP_0688 ENOG4108TZV Membrane ALFP_0689 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) ALFP_0699 ENOG4105BZU Histidine kinase ALFP_0700 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) ALFP_0701 ENOG4108JU5 Magnesium and cobalt efflux protein ALFP_0702 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) ALFP_0703 ENOG4105C9A Phoh family ALFP_0704 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) ALFP_0706 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) ALFP_0707 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) ALFP_0708 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) ALFP_0709 ENOG4105VIE preprotein translocase, subunit YajC ALFP_0710 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) ALFP_0711 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) ALFP_0712 ENOG4106HRJ d-alanyl-d-alanine carboxypeptidase ALFP_0713 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) ALFP_0715 ENOG4105NE1 Conserved Protein ALFP_0718 ENOG4105W8I Transcriptional regulator ALFP_0721 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase ALFP_0724 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) ALFP_0726 ENOG4105CSH Transporter ALFP_0729 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) ALFP_0731 ENOG4105CHM Aminotransferase ALFP_0734 ENOG4105C6K Malic enzyme ALFP_0736 ENOG41067XF inhibitor ALFP_0737 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) ALFP_0738 ENOG4105CV1 Transketolase (EC 2.2.1.1) ALFP_0739 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase ALFP_0740 ENOG4105BZA Phosphoglycerate kinase ALFP_0745 ENOG4108RIR Molybdenum cofactor biosynthesis protein ALFP_0747 ENOG4105C8V SAICAR synthetase ALFP_0748 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) ALFP_0749 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit ALFP_0750 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) ALFP_0751 ENOG4108YIQ Alpha beta hydrolase ALFP_0752 ENOG4105DXM phenylacetic acid degradation protein ALFP_0753 ENOG4105C1G acyl-Coa dehydrogenase ALFP_0754 ENOG4108MGI Transcriptional regulator ALFP_0755 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) ALFP_0757 ENOG4105D5U fad dependent oxidoreductase ALFP_0759 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) ALFP_0761 ENOG4105CUZ uba thif-type nad fad binding protein ALFP_0763 ENOG4105CRQ synthase (Component I) ALFP_0764 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) ALFP_0766 ENOG4108SHN Glycosyl transferase, family 2 ALFP_0768 ENOG4105C5H ABC transporter ALFP_0772 ENOG4105VJP Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity) ALFP_0773 ENOG4107QMS site-determining protein ALFP_0775 ENOG4105CX6 glutaminyL-tRNA synthetase ALFP_0776 ENOG4105C4M (Ubiquinol oxidase) subunit I ALFP_0777 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii ALFP_0780 ENOG4105C9U ATP-dependent DNA helicase RecQ ALFP_0781 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) ALFP_0782 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) ALFP_0783 ENOG4105XPH Ferredoxin ALFP_0784 ENOG4105C5H ABC transporter ALFP_0785 ENOG4108V6E Cell division protein mraZ ALFP_0786 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) ALFP_0787 ENOG4105N8N Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) ALFP_0788 ENOG4105CJN penicillin-binding protein ALFP_0789 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) ALFP_0790 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) ALFP_0791 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) ALFP_0793 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) ALFP_0794 ENOG4105DFU Cell wall formation (By similarity) ALFP_0795 ENOG4105CPF Cell wall formation (By similarity) ALFP_0796 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) ALFP_0797 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) ALFP_0798 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) ALFP_0799 ENOG4105C7C involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) ALFP_0801 ENOG4105E4C Lytic transglycosylase catalytic ALFP_0802 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving ALFP_0804 ENOG4105CJW magnesium transporter ALFP_0805 ENOG4105NAU thioesterase Superfamily protein ALFP_0806 ENOG4105CH2 amidohydrolase ALFP_0807 ENOG4105CEY Amp-dependent synthetase and ligase ALFP_0808 ENOG4105ECY inositol monophosphatase ALFP_0809 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) ALFP_0811 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) ALFP_0812 ENOG4108UMI ABC transporter, permease ALFP_0813 ENOG4105D01 (LipO)protein ALFP_0814 ENOG4107R0W ABC transporter ALFP_0815 ENOG4105E5Q amino acid AbC transporter ALFP_0816 ENOG4105CDA abc transporter atp-binding protein ALFP_0818 ENOG4108S0S Nucleotidyl transferase ALFP_0819 ENOG4105EHM Aminoglycoside phosphotransferase ALFP_0821 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) ALFP_0822 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) ALFP_0826 ENOG4105E9Q Acyl-transferase ALFP_0827 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase ALFP_0828 ENOG4105C38 Glycyl-tRNA synthetase beta subunit ALFP_0829 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit ALFP_0831 ENOG4106YT9 Enoyl-CoA hydratase ALFP_0832 ENOG4107GFK fumarate ALFP_0833 ENOG4108IG5 Transcriptional regulator ALFP_0835 ENOG4105F27 Major Facilitator ALFP_0838 ENOG4108UN4 phage SPO1 DNA polymerase-related protein ALFP_0839 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase ALFP_0840 ENOG4105DJ0 Poly(A) Polymerase ALFP_0842 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) ALFP_0843 ENOG4105CXB phosphoribosylaminoimidazole synthetase ALFP_0844 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease ALFP_0845 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) ALFP_0846 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) ALFP_0847 ENOG4105DQR SNARE associated Golgi ALFP_0848 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase ALFP_0849 ENOG4105K8N protein family UPF0079, ATPase ALFP_0852 ENOG4105C6K Malic enzyme ALFP_0853 ENOG4105DDW LysR family Transcriptional regulator ALFP_0854 ENOG4105C26 Dehydrogenase ALFP_0855 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) ALFP_0857 ENOG4105CG6 trap dicarboxylate transporter dctm subunit ALFP_0864 ENOG4105KVH Transcriptional regulator ALFP_0865 ENOG4108RYK Nad-dependent epimerase dehydratase ALFP_0869 ENOG4108Z66 YbaK ebsC protein ALFP_0870 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) ALFP_0871 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein ALFP_0872 ENOG4105E0C molybdate abc transporter ALFP_0873 ENOG4108IJ6 ABC transporter ALFP_0874 ENOG4105F4R Transcriptional regulator mode ALFP_0876 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation ALFP_0877 ENOG4107QMP dna polymerase iii subunits gamma and tau ALFP_0879 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) ALFP_0880 ENOG4107BVJ 4,5-dihydroxyphthalate decarboxylase ALFP_0882 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component ALFP_0886 ENOG4108NS2 receptor ALFP_0887 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) ALFP_0888 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain ALFP_0889 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain ALFP_0893 ENOG4105C2W permease ALFP_0894 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) ALFP_0895 ENOG4105HBR Rna-binding protein ALFP_0896 ENOG4105F7M Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity) ALFP_0897 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) ALFP_0899 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) ALFP_0901 ENOG4105C9X ppx gppa phosphatase ALFP_0902 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) ALFP_0903 ENOG4107QMV Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) ALFP_0904 ENOG4105C8U phosphate abc transporter ALFP_0905 ENOG4105E2Z phosphate ABC transporter (Permease ALFP_0906 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) ALFP_0910 ENOG4105XJC Two component transcriptional regulator (Winged helix family ALFP_0911 ENOG4105E0F Histidine kinase ALFP_0914 ENOG4105GZI Transcriptional regulator ALFP_0917 ENOG4107TJ9 Cytochrome ALFP_0918 ENOG4107VMU Membrane ALFP_0920 ENOG4105E0M Sulfatase ALFP_0925 ENOG4107QN1 sodium solute ALFP_0926 ENOG4105V9J phenylacetic acid degradation operon negative regulatory protein ALFP_0927 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) ALFP_0929 ENOG4107RTD sua5 ycio yrdc ywlc family protein ALFP_0930 ENOG4108Z4T Peptidase M50 ALFP_0931 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) ALFP_0932 ENOG4105GJM (LipO)protein ALFP_0935 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) ALFP_0937 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) ALFP_0938 ENOG4106A3M Cytochrome p-450 ALFP_0940 ENOG4105DKK Benzoate ALFP_0942 ENOG4105EZE Cupin 4 family protein ALFP_0943 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) ALFP_0945 ENOG4108NS2 receptor ALFP_0947 ENOG4105DJY efflux transporter, rnd family, mfp subunit ALFP_0948 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) ALFP_0949 ENOG4105ENJ RND efflux system, outer membrane lipoprotein ALFP_0950 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) ALFP_0951 ENOG4105BZ1 (ABC) transporter ALFP_0952 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) ALFP_0955 ENOG4105DEN Luciferase family ALFP_0957 ENOG4105D64 Mechanosensitive ion channel ALFP_0958 ENOG4108K70 Transcriptional regulator ALFP_0966 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) ALFP_0969 ENOG4105ECY inositol monophosphatase ALFP_0970 ENOG4105EE5 Membrane protein terC ALFP_0971 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) ALFP_0974 ENOG4105F10 Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity) ALFP_0977 ENOG4105C8N cysteinyl-tRNA synthetase ALFP_0979 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) ALFP_0980 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) ALFP_0981 ENOG4105CFH Aspartokinase ALFP_0984 ENOG4105EPW hflc protein ALFP_0986 ENOG4107S4Z Activates expression of the rhaBAD and rhaT operons (By similarity) ALFP_0991 ENOG4105ECW sulfate abc transporter ALFP_0992 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) ALFP_0993 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) ALFP_0994 ENOG4105W8H transhydrogenase (subunit alpha ALFP_0995 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) ALFP_0999 ENOG4105DMF Dehydrogenase ALFP_1000 ENOG4105CHF Glutathione S-transferase ALFP_1001 ENOG4105CS1 NAD(P)H quinone oxidoreductase ALFP_1005 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) ALFP_1007 ENOG4105D7N magnesium and cobalt transport protein CorA ALFP_1008 ENOG4105CSU acyl-Coa dehydrogenase ALFP_1012 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component ALFP_1013 ENOG4108JQ6 ABC transporter ALFP_1015 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family ALFP_1017 ENOG4105C26 Dehydrogenase ALFP_1018 ENOG4105C0A alcohol dehydrogenase ALFP_1019 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) ALFP_1022 ENOG4105CG6 trap dicarboxylate transporter dctm subunit ALFP_1022 ENOG4105CG6 trap dicarboxylate transporter dctm subunit ALFP_1024 ENOG4105CH5 extracellular solute-binding protein, family 7 ALFP_1026 ENOG4107QIJ Aconitate hydratase 2 ALFP_1029 ENOG4105BZN citrate synthase ALFP_1030 ENOG4105CR4 methylisocitrate lyase ALFP_1031 ENOG4108JU7 Transcriptional regulator ALFP_1034 ENOG4105D9Z Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) ALFP_1035 ENOG4105FDP GntR family transcriptional regulator ALFP_1036 ENOG4108UTY succinate dehydrogenase, cytochrome b556 subunit ALFP_1039 ENOG4105E33 succinate dehydrogenase ALFP_1040 ENOG41060IS Flavinator of succinate dehydrogenase ALFP_1041 ENOG4105BZN citrate synthase ALFP_1042 ENOG41073TP transcriptional regulator ALFP_1043 ENOG4105DAA L-lactate ALFP_1044 ENOG4105C6K Malic enzyme ALFP_1046 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 ALFP_1047 ENOG4105C7S Dehydrogenase ALFP_1048 ENOG4107QN2 dihydrolipoyl dehydrogenase ALFP_1049 ENOG4105D6Z AFG1 family ATPase ALFP_1050 ENOG4105C31 Tryptophanyl-tRNA synthetase ALFP_1053 ENOG4105BZM domain protein ALFP_1054 ENOG4105DVT helicase ALFP_1056 ENOG4105KVH Transcriptional regulator ALFP_1058 ENOG4105NDK ethanolamine utilization protein ALFP_1059 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) ALFP_1062 ENOG4105CG6 trap dicarboxylate transporter dctm subunit ALFP_1064 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane ALFP_1065 ENOG4105C34 Pseudouridine synthase ALFP_1066 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase ALFP_1067 ENOG4105D1N poly(r)-hydroxyalkanoic acid synthase, class ALFP_1068 ENOG4105CHR reductase ALFP_1069 ENOG4108NVM synthesis repressor PhaR ALFP_1072 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) ALFP_1073 ENOG4105FE9 pseudouridine synthase ALFP_1074 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) ALFP_1075 ENOG4105CHV Transcription elongation factor NusA ALFP_1076 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) ALFP_1077 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) ALFP_1078 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) ALFP_1080 ENOG4107SA8 fad-dependent pyridine nucleotide-disulfide oxidoreductase ALFP_1082 ENOG4106YG3 ABC transporter ALFP_1083 ENOG4105DSP amino acid AbC transporter ALFP_1084 ENOG4105E89 ABC transporter ALFP_1085 ENOG4108URH decarboxylase ALFP_1086 ENOG4105C2M dna polymerase I ALFP_1087 ENOG4105EAM Na Pi-cotransporter ALFP_1089 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) ALFP_1091 ENOG4105KEG ribosomal-protein-alanine acetyltransferase ALFP_1092 ENOG4105D0M Protease HtpX homolog ALFP_1095 ENOG4105KHC sulfurtransferase ALFP_1096 ENOG41082UU Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) ALFP_1097 ENOG4105CTB Polyprenyl synthetase ALFP_1098 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) ALFP_1099 ENOG4105DZA Converts GTP to 7,8-dihydroneopterin triphosphate (By similarity) ALFP_1100 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) ALFP_1102 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) ALFP_1103 ENOG4105K9Q Binds to the 23S rRNA (By similarity) ALFP_1104 ENOG4105CDU Replicative dna helicase ALFP_1105 ENOG4105DHU Bile acid ALFP_1106 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) ALFP_1107 ENOG4108IAB Phoh family ALFP_1108 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen ALFP_1110 ENOG4105CHM Aminotransferase ALFP_1111 ENOG4105D6E homoserine dehydrogenase ALFP_1113 ENOG4108MK9 spermidine N(1)-acetyltransferase ALFP_1114 ENOG4105CVN desaturase ALFP_1116 ENOG4105FBD synthase ALFP_1117 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) ALFP_1118 ENOG4105CHR reductase ALFP_1119 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) ALFP_1123 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) ALFP_1124 ENOG4105F38 ABC transporter, permease ALFP_1125 ENOG4105D38 putrescine abc transporter ALFP_1127 ENOG4105E66 phosphoriboisomerase A ALFP_1128 ENOG4108UTW Plays a role in the regulation of phosphate uptake ALFP_1130 ENOG4105CHH sulfate transporter ALFP_1131 ENOG4105KMG Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes (By similarity) ALFP_1133 ENOG4108EKC n-acetylglutamate synthase ALFP_1134 ENOG4105CQ7 ATP-dependent helicase ALFP_1135 ENOG4105C0B DNA polymerase III (alpha subunit) ALFP_1136 ENOG4105CPK Glycosyl transferase (Group 1 ALFP_1137 ENOG4107BJW polysaccharide deacetylase ALFP_1138 ENOG4106WTF Glycosyl transferase, family 2 ALFP_1140 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) ALFP_1143 ENOG4105KRS Proteinase inhibitor ALFP_1146 ENOG4105BZ1 (ABC) transporter ALFP_1149 ENOG4105C03 ribonuclease ALFP_1151 ENOG4108KWP DNA-binding transcriptional regulator GlcC ALFP_1152 ENOG4105CQB FAD linked oxidase domain protein ALFP_1153 ENOG4105EU8 FAD linked oxidase domain protein ALFP_1154 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) ALFP_1158 ENOG4108REF Sporulation integral membrane protein ytvi ALFP_1161 ENOG4108Z9W Outer membrane porin ALFP_1162 ENOG4106UX7 integral membrane protein ALFP_1164 ENOG4105DUM transcriptional regulator, lysR family ALFP_1166 ENOG4108YY7 Invasion gene expression up-regulator SirB ALFP_1168 ENOG41080HT Transcriptional regulator, arsr family ALFP_1174 ENOG4105CHH sulfate transporter ALFP_1175 ENOG4105E6M Sulphatase-modifying factor protein ALFP_1176 ENOG4107QRH Arylsulfatase (Ec 3.1.6.1) ALFP_1177 ENOG4105YB8 TM2 domain containing protein ALFP_1178 ENOG4107QVN Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) ALFP_1179 ENOG4105C6V Glycerol-3-phosphate dehydrogenase ALFP_1180 ENOG4105K4H Nlp p60 protein ALFP_1181 ENOG4105GEH Functions in complex with FlhC as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region. Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes. Also regulates genes whose products function in a variety of physiological pathways (By similarity) ALFP_1182 ENOG4106CIA Functions in complex with FlhD as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region ALFP_1183 ENOG4107RD7 Flagellar Motor Protein, MotA ALFP_1184 ENOG4105ER2 Ompa motb domain protein ALFP_1185 ENOG4105CBS Chea signal transduction histidine kinase ALFP_1186 ENOG4108V3W Chemotaxis protein, CheW ALFP_1187 ENOG4105C8Q Methyl-accepting chemotaxis ALFP_1188 ENOG4105BZU Histidine kinase ALFP_1190 ENOG4108VYJ response regulator receiver protein ALFP_1191 ENOG4108KCC Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P) (By similarity) ALFP_1192 ENOG4105D00 flagellar biosynthetic protein flhB ALFP_1193 ENOG4105D7B Flagellar biosynthesis protein flha ALFP_1194 ENOG4105FZW flagellar biosynthesis regulator FlhF ALFP_1195 ENOG4105CAF HipA N-terminal domain protein ALFP_1199 ENOG4105M9M anti-sigma28 factor FlgM ALFP_1201 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) ALFP_1202 ENOG4108ZC9 flagellar basal-body rod protein flgc ALFP_1203 ENOG4105W00 Flagellar hook capping protein ALFP_1204 ENOG4105BZE flagellar hook protein, FlgE ALFP_1205 ENOG4108KPB Flagellar basal-body rod protein FlgF ALFP_1206 ENOG4105CGA flagellar basal-body rod protein FlgG ALFP_1208 ENOG4105D92 Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) ALFP_1209 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj ALFP_1210 ENOG4105E1Q flagellar hook-associated protein ALFP_1211 ENOG4105DTJ flagellar hook-associated protein ALFP_1212 ENOG4105C8Q Methyl-accepting chemotaxis ALFP_1214 ENOG4105C8Q Methyl-accepting chemotaxis ALFP_1216 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) ALFP_1217 ENOG4105D19 Role in flagellar biosynthesis (By similarity) ALFP_1218 ENOG4105VS8 Flagellar biosynthetic protein fliq ALFP_1219 ENOG4105CN7 Flagellar biosynthetic protein FliP ALFP_1221 ENOG4105DD5 Flagellar motor switch protein ALFP_1222 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) ALFP_1223 ENOG4107ZI8 flagellar basal body-associated protein flil ALFP_1226 ENOG4108JIR Flagellum-specific ATP synthase ALFP_1228 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) ALFP_1229 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) ALFP_1230 ENOG4105VQ0 flagellar hook-basal body complex protein fliE ALFP_1231 ENOG4105D00 flagellar biosynthetic protein flhB ALFP_1234 ENOG4105MQ3 flagellar protein FliS ALFP_1235 ENOG4105DTS flagellar hook-associated ALFP_1236 ENOG41063QE flagellar protein FlaG ALFP_1237 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) ALFP_1240 ENOG4105I03 Flagellin ALFP_1247 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) ALFP_1249 ENOG4105E6M Sulphatase-modifying factor protein ALFP_1253 ENOG4106BRA Membrane ALFP_1254 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor ALFP_1255 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor ALFP_1257 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase ALFP_1260 ENOG4105CY2 Citrate transporter ALFP_1262 ENOG4108KU3 Integrase ALFP_1265 ENOG4107QRH Arylsulfatase (Ec 3.1.6.1) ALFP_1266 ENOG4105JQN Transcriptional regulator ALFP_1269 ENOG4105ENJ RND efflux system, outer membrane lipoprotein ALFP_1270 ENOG4106FTQ Taurine ABC transporter, periplasmic ALFP_1271 ENOG4108IY8 ABC, transporter ALFP_1272 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component ALFP_1273 ENOG4105CHR reductase ALFP_1274 ENOG4105ETT transcriptional Regulator, LysR family ALFP_1279 ENOG4105CG6 trap dicarboxylate transporter dctm subunit ALFP_1280 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA ALFP_1282 ENOG4105CG6 trap dicarboxylate transporter dctm subunit ALFP_1284 ENOG4105C85 amino acid ALFP_1288 ENOG4105CC0 LysR family Transcriptional regulator ALFP_1289 ENOG4105VTN Protein of unknown function (DUF1311) ALFP_1290 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) ALFP_1297 ENOG4107S7U Sulfide dehydrogenase ALFP_1302 ENOG4105VEQ Cold shock protein ALFP_1303 ENOG4105DHQ Histidine kinase ALFP_1304 ENOG4105XJC Two component transcriptional regulator (Winged helix family ALFP_1305 ENOG4105EUH cytochrome C oxidase, cbb3-type, subunit i ALFP_1307 ENOG41090Y2 cytochrome C ALFP_1308 ENOG4105NQN cytochrome C ALFP_1310 ENOG4105EQR Transposase IS116 IS110 IS902 ALFP_1313 ENOG4108R1E Serine threonine protein phosphatase 1 ALFP_1314 ENOG4105E0K tonB-dependent siderophore receptor ALFP_1321 ENOG4105EEQ Na H antiporter ALFP_1323 ENOG4105J12 Multidrug resistance protein mdtN ALFP_1324 ENOG4105EM2 membrane ALFP_1326 ENOG4105C7N Xanthine uracil vitamin C permease ALFP_1327 ENOG41083B3 HAD-superfamily subfamily IB hydrolase ALFP_1332 ENOG4105CBC glutamate synthase ALFP_1334 ENOG4108SY4 MarR family Transcriptional regulator ALFP_1336 ENOG4108I0Z Aconitate hydratase ALFP_1344 ENOG4105CYX Short-chain dehydrogenase reductase Sdr ALFP_1346 ENOG4105EGS Mechanosensitive ion channel ALFP_1347 ENOG4105EGS Mechanosensitive ion channel ALFP_1348 ENOG4105CSH Transporter ALFP_1351 ENOG4108IMY Transcriptional regulator ALFP_1352 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase ALFP_1353 ENOG4105BZU Histidine kinase ALFP_1354 ENOG4105CJW magnesium transporter ALFP_1357 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) ALFP_1358 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) ALFP_1361 ENOG4108W0I acetyltransferase ALFP_1362 ENOG4105K5B UPF0225 protein ALFP_1364 ENOG4108K0D peptidase, M48 ALFP_1365 ENOG4105F27 Major Facilitator ALFP_1375 ENOG4105BZU Histidine kinase ALFP_1378 ENOG4108XM1 transcriptional regulator AsnC family ALFP_1379 ENOG4105C28 cystathionine ALFP_1381 ENOG4105M6F mutator MutT protein ALFP_1382 ENOG4105WD1 Membrane ALFP_1384 ENOG4105CDH Citrulline--aspartate ligase ALFP_1385 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) ALFP_1386 ENOG4108IJ6 ABC transporter ALFP_1390 ENOG4105ETE Transcriptional regulator (LacI family ALFP_1393 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) ALFP_1395 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) ALFP_1396 ENOG4105C08 Histidine kinase ALFP_1397 ENOG4105EEX Two component transcriptional regulator (Winged helix family ALFP_1398 ENOG4105DBV ornithine carbamoyltransferase ALFP_1400 ENOG4105C5I Dehydrogenase ALFP_1401 ENOG41082GY Binds directly to 16S ribosomal RNA (By similarity) ALFP_1402 ENOG4105CJR Integral membrane protein (MviN ALFP_1404 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) ALFP_1405 ENOG4105CET Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) ALFP_1406 ENOG4105W49 UPF0434 protein ALFP_1407 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) ALFP_1408 ENOG4105M8F Biopolymer transport protein exbD tolR ALFP_1409 ENOG41090AP transport protein ALFP_1410 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) ALFP_1411 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) ALFP_1412 ENOG4108UWD Iron-storage protein ALFP_1413 ENOG4105CHU acetyl-coa acetyltransferase ALFP_1415 ENOG4105VEQ Cold shock protein ALFP_1416 ENOG4105KAE Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) ALFP_1417 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit ALFP_1418 ENOG4105F1S paraquat-inducible protein a ALFP_1420 ENOG4105DY2 Paraquat-inducible protein b ALFP_1424 ENOG4105C32 Amino acid ABC transporter (Permease) ALFP_1425 ENOG4105CF8 branched-chain amino acid ABC transporter, permease ALFP_1426 ENOG4105C0Z ABC transporter ALFP_1427 ENOG4108IV0 ABC, transporter ALFP_1432 ENOG4105EBA Specifically methylates the adenine in position 1618 of 23S rRNA (By similarity) ALFP_1433 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) ALFP_1434 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase ALFP_1435 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) ALFP_1436 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) ALFP_1437 ENOG4105DTN riboflavin biosynthesis protein ribF ALFP_1438 ENOG4108V3E phosphoribosylglycinamide formyltransferase ALFP_1441 ENOG4105C4R Atp-dependent dna helicase ALFP_1450 ENOG4105F9N Major Facilitator Superfamily ALFP_1452 ENOG4105C5H ABC transporter ALFP_1453 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) ALFP_1454 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) ALFP_1455 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) ALFP_1457 ENOG4105R1U AraC Family Transcriptional Regulator ALFP_1468 ENOG4108Z4X TRANSCRIPTIONal ALFP_1470 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F ALFP_1471 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation ALFP_1472 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) ALFP_1473 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) ALFP_1474 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) ALFP_1477 ENOG4108428 Inherit from COG: -acetyltransferase ALFP_1478 ENOG4105CGF Aromatic amino acid aminotransferase ALFP_1479 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) ALFP_1483 ENOG4105C3J Cysteine desulfurase ALFP_1484 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins ALFP_1485 ENOG4108Z4V iron-sulfur cluster assembly ALFP_1489 ENOG4105CRK lysyL-tRNA synthetase ALFP_1490 ENOG4105PDP Short chain dehydrogenase ALFP_1491 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) ALFP_1492 ENOG4105C8Q Methyl-accepting chemotaxis ALFP_1493 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) ALFP_1494 ENOG4108IPJ Membrane ALFP_1495 ENOG4105C09 Bile acid ALFP_1497 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) ALFP_1500 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) ALFP_1501 ENOG4105EYA deoxyribonuclease ALFP_1502 ENOG4108EC8 DNA internalization-related competence protein ComEC ALFP_1503 ENOG4108EV1 Haloalkane dehalogenase ALFP_1504 ENOG4105DB7 PHP domain protein ALFP_1506 ENOG4108ETH Formylglycinamide ribotide synthetase ALFP_1507 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) ALFP_1512 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) ALFP_1513 ENOG4105J1P transposase, IS3 IS911 family protein ALFP_1521 ENOG4105ER2 Ompa motb domain protein ALFP_1527 ENOG4105KPY Small multidrug resistance protein ALFP_1528 ENOG4108R85 Short chain dehydrogenase ALFP_1529 ENOG4105DZ2 Transcriptional regulator ALFP_1534 ENOG4105CSU acyl-Coa dehydrogenase ALFP_1537 ENOG4105D29 Helix-turn-helix type 11 domain protein ALFP_1538 ENOG4105CKI cobalamin synthesis protein ALFP_1539 ENOG4105DZA Converts GTP to 7,8-dihydroneopterin triphosphate (By similarity) ALFP_1542 ENOG4105CD3 dihydroorotase ALFP_1543 ENOG41090R7 Ferric uptake ALFP_1544 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase ALFP_1548 ENOG4105ETX regulatoR ALFP_1549 ENOG4105DWF phosphomethylpyrimidine kinase ALFP_1552 ENOG4107Z11 Efflux pump whose substrates are p-hydroxybenzoic acid (pHBA), 6-hydroxy-2-naphthoic and 2-hydroxycinnamate. Could function as a metabolic relief valve, allowing to eliminate certain compounds when they accumulate to high levels in the cell (By similarity) ALFP_1554 ENOG4105Y49 secretion protein, HlyD family ALFP_1556 ENOG41090U3 tautomerase ALFP_1557 ENOG4108EGH Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) ALFP_1558 ENOG4105C26 Dehydrogenase ALFP_1559 ENOG41062QD Membrane ALFP_1560 ENOG4107QN1 sodium solute ALFP_1562 ENOG4105EA8 2-Nitropropane dioxygenase ALFP_1568 ENOG4108JGH Tetr family transcriptional regulator ALFP_1572 ENOG4105EJC lysr family transcriptional regulator ALFP_1577 ENOG4108S10 Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) ALFP_1587 ENOG410846T CoA-transferase family III ALFP_1589 ENOG4105C1G acyl-Coa dehydrogenase ALFP_1594 ENOG41080HT Transcriptional regulator, arsr family ALFP_1599 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) ALFP_1604 ENOG410626B catechol 1,2-dioxygenase ALFP_1606 ENOG4107QNJ CoA-transferase subunit B ALFP_1607 ENOG4105F2Z 3-oxoadipate enol-lactonase ALFP_1609 ENOG4105DKK Benzoate ALFP_1610 ENOG4108MR5 ALFP_1611 ENOG4108MZY ALFP_1613 ENOG4108IUW ABC transporter ALFP_1615 ENOG4105WH1 Two component transcriptional regulator luxr family ALFP_1616 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) ALFP_1622 ENOG4108VHT MarR family transcriptional regulator ALFP_1623 ENOG4105MSY salicylate hydroxylase ALFP_1624 ENOG4105CSP Major Facilitator Superfamily ALFP_1626 ENOG4105DFA alanine racemase domain protein ALFP_1627 ENOG4105CSW GntR family transcriptional regulator ALFP_1628 ENOG4108KTG Membrane protein, drug metabolite transporter ALFP_1630 ENOG4105F2V VRR-NUC domain-containing protein ALFP_1634 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) ALFP_1635 ENOG4105CPC Aldo Keto reductase ALFP_1640 ENOG4105ID8 Transcriptional regulator, ARAC family ALFP_1642 ENOG4105IGJ Zn-dependent Hydrolase of the beta-lactamase fold protein ALFP_1643 ENOG4108W2Y isochorismatase ALFP_1645 ENOG4108RAV Conserved protein ALFP_1649 ENOG4108UT2 hemolysin iii ALFP_1650 ENOG4105KWI UPF0339 protein ALFP_1654 ENOG4105EAB amino acid AbC transporter ALFP_1655 ENOG4105E5Q amino acid AbC transporter ALFP_1656 ENOG4105DRP amino acid AbC transporter ALFP_1657 ENOG4105CDA abc transporter atp-binding protein ALFP_1664 ENOG4105EUV Phenol 2-monooxygenase ALFP_1668 ENOG4108JA0 Oxidoreductase, FAD NAD(P)-binding domain protein ALFP_1674 ENOG4105D2S major facilitator superfamily ALFP_1678 ENOG4105ETE Transcriptional regulator (LacI family ALFP_1680 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) ALFP_1685 ENOG4107QX8 SPFH domain, Band 7 family protein ALFP_1686 ENOG4105G5H Membrane ALFP_1687 ENOG4108D32 Methyltransferase ALFP_1689 ENOG4105UCG Domain of unknown function (DUF333) ALFP_1691 ENOG4108MGF sugar kinase ALFP_1696 ENOG4105C22 threonyL-tRNA synthetase ALFP_1697 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) ALFP_1698 ENOG4105D7Z glutathione synthase ALFP_1700 ENOG41080Z8 PHOSPHOCARRIER protein ALFP_1701 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) ALFP_1706 ENOG4105C0P Mg chelatase subunit ChlI ALFP_1707 ENOG4105VJV 50s ribosomal protein L35 ALFP_1708 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) ALFP_1709 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) ALFP_1710 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) ALFP_1711 ENOG4108ZUF This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) ALFP_1713 ENOG4105ED9 Protein of unknown function (DUF455) ALFP_1715 ENOG4108JJ7 ABC transporter ALFP_1716 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family ALFP_1718 ENOG4105C3K feS assembly ATPase SufC ALFP_1719 ENOG4105JRK feS assembly protein SufD ALFP_1720 ENOG4105C9B Cysteine desulfurase ALFP_1721 ENOG4108UNV SUF system FeS assembly protein, NifU family ALFP_1722 ENOG4105VG1 fes assembly suf system protein ALFP_1726 ENOG4105DFG type I secretion outer membrane protein ALFP_1729 ENOG4107QZV Type I secretion membrane fusion protein ALFP_1733 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) ALFP_1734 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) ALFP_1735 ENOG4105CPF Cell wall formation (By similarity) ALFP_1736 ENOG4105HX0 Transcriptional regulator ALFP_1737 ENOG4107RCH Diaminopropionate ammonia-lyase ALFP_1738 ENOG4105CE7 Amidase, hydantoinase carbamoylase family ALFP_1742 ENOG4108JQ6 ABC transporter ALFP_1744 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) ALFP_1751 ENOG4108DEF Globin ALFP_1752 ENOG4105KPV Transcriptional regulator ALFP_1769 ENOG4105CAR Terminase, large subunit ALFP_1776 ENOG41061CV Terminase small subunit ALFP_1779 ENOG41090AG Bacteriophage protein ALFP_1807 ENOG4108RAV Conserved protein ALFP_1815 ENOG4105BZC d-serine deaminase ALFP_1816 ENOG4105NQN cytochrome C ALFP_1818 ENOG4105FC8 fad dependent oxidoreductase ALFP_1819 ENOG4108K88 Membrane ALFP_1821 ENOG4105E6M Sulphatase-modifying factor protein ALFP_1824 ENOG4105CZN Potassium uptake protein ALFP_1826 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase ALFP_1828 ENOG4105KTH gatB Yqey ALFP_1829 ENOG4105C0B DNA polymerase III (alpha subunit) ALFP_1837 ENOG4105DUM transcriptional regulator, lysR family ALFP_1838 ENOG41061WM D-Alanyl-D-Alanine ALFP_1840 ENOG4107R0U MotA TolQ exbB proton channel ALFP_1841 ENOG4105ER2 Ompa motb domain protein ALFP_1843 ENOG4105FGE Short-chain dehydrogenase reductase Sdr ALFP_1844 ENOG4105CPU Monooxygenase ALFP_1845 ENOG4105EMU Dehydrogenase ALFP_1846 ENOG4108R6K riboflavin synthase, subunit alpha ALFP_1848 ENOG4105DB1 molybdopterin oxidoreductase ALFP_1849 ENOG4106WHD Tetrathionate reductase ALFP_1850 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein ALFP_1851 ENOG4107RNH Outer membrane receptor FepA ALFP_1854 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) ALFP_1855 ENOG4105C2W permease ALFP_1856 ENOG4107Y70 Heat shock protein ALFP_1857 ENOG4105CH2 amidohydrolase ALFP_1859 ENOG4105C0R drug resistance transporter emrb qaca subfamily ALFP_1865 ENOG4105E09 nadh pyrophosphatase ALFP_1866 ENOG4105DSJ YicC domain protein ALFP_1867 ENOG4107RFY SbcCD D subunit ALFP_1869 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) ALFP_1870 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) ALFP_1871 ENOG4105CSA Coproporphyrinogen iii oxidase ALFP_1872 ENOG4105C5F glutamine synthetase ALFP_1873 ENOG4107YB6 acetyltransferase, (GNAT) family ALFP_1877 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) ALFP_1878 ENOG4107Z6A sulfate abc transporter permease ALFP_1879 ENOG4107QKW extracellular solute-binding protein family 1 ALFP_1880 ENOG4105DP0 ferredoxin-NADP reductase ALFP_1881 ENOG4105KME endoribonuclease L-psp ALFP_1882 ENOG4105CB5 ATP-dependent DNA helicase recG ALFP_1885 ENOG4105CP9 extracellular ligand-binding receptor ALFP_1886 ENOG4108IJ9 (ABC) transporter ALFP_1889 ENOG4105BZ7 extracellular solute-binding protein family 1 ALFP_1890 ENOG4105II7 pyrroline-5-carboxylate reductase ALFP_1891 ENOG4105CP9 extracellular ligand-binding receptor ALFP_1892 ENOG4105C32 Amino acid ABC transporter (Permease) ALFP_1893 ENOG4105CF8 branched-chain amino acid ABC transporter, permease ALFP_1894 ENOG4105C0Z ABC transporter ALFP_1895 ENOG4108IV0 ABC, transporter ALFP_1896 ENOG4108K3A Glutathione S-transferase ALFP_1898 ENOG4105C5I Dehydrogenase ALFP_1899 ENOG4105CHR reductase ALFP_1901 ENOG4105C9Q fumarate hydratase class II ALFP_1902 ENOG4105D8V Glucose sorbosone dehydrogenase ALFP_1903 ENOG4108I0C methyltransferase ALFP_1904 ENOG4107YZX Universal stress protein ALFP_1906 ENOG4105R1U AraC Family Transcriptional Regulator ALFP_1907 ENOG4105C9J Catalyzes the reversible cleavage of L-rhamnulose-1- phosphate to dihydroxyacetone phosphate (DHAP) and L-lactaldehyde (By similarity) ALFP_1909 ENOG4105C26 Dehydrogenase ALFP_1910 ENOG4107SCK Monooxygenase ALFP_1911 ENOG4105DJ2 Major Facilitator Superfamily ALFP_1913 ENOG4105EJC lysr family transcriptional regulator ALFP_1916 ENOG4108V0E nucleoside 2-deoxyribosyltransferase YtoQ ALFP_1920 ENOG4105CR8 Transcriptional regulator ALFP_1921 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) ALFP_1925 ENOG4105E3B Multicopper oxidase ALFP_1926 ENOG4108EF9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR ALFP_1928 ENOG4105CSR polyphosphate kinase 2 ALFP_1929 ENOG4105CYX Short-chain dehydrogenase reductase Sdr ALFP_1934 ENOG4105CPW cytochrome b561 ALFP_1936 ENOG4108YYC ycei family ALFP_1937 ENOG4105K89 arsenate reductase ALFP_1938 ENOG4105CYM Glutathione S-transferase ALFP_1940 ENOG4108YYH Nadph-dependent fmn reductase ALFP_1942 ENOG4105F8V Hydrolase, tatD family ALFP_1943 ENOG4107QRG dna polymerase iii ALFP_1945 ENOG4105HHA aminodeoxychorismate lyase ALFP_1946 ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) ALFP_1947 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase ALFP_1949 ENOG4105C1G acyl-Coa dehydrogenase ALFP_1950 ENOG4105VDB UPF0125 protein ALFP_1951 ENOG4108Z1B Cyclase dehydrase ALFP_1952 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) ALFP_1953 ENOG4105CEP NADH dehydrogenase ALFP_1954 ENOG410630P Transcriptional regulator ALFP_1955 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) ALFP_1956 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) ALFP_1959 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) ALFP_1960 ENOG4105D0V Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) ALFP_1962 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) ALFP_1963 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) ALFP_1965 ENOG4105E1Z Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane ALFP_1966 ENOG4105DZP Membrane-associated zinc metalloprotease ALFP_1967 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) ALFP_1968 ENOG4105KNE Phosphatidate cytidylyltransferase ALFP_1969 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) ALFP_1970 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) ALFP_1971 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) ALFP_1972 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) ALFP_1973 ENOG4105CE9 30S ribosomal protein S2 ALFP_1974 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) ALFP_1975 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) ALFP_1978 ENOG4107S1E Beta-lactamase ALFP_1979 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase ALFP_1980 ENOG4105E96 Colicin v production protein ALFP_1982 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase ALFP_1983 ENOG4107QN2 dihydrolipoyl dehydrogenase ALFP_1984 ENOG4107QSN dihydrolipoamide acetyltransferase ALFP_1985 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) ALFP_1986 ENOG4105BZU Histidine kinase ALFP_1988 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) ALFP_1989 ENOG4105DGW oligopeptidase A ALFP_1991 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) ALFP_1992 ENOG4105YVS arsR family transcriptional regulator ALFP_1994 ENOG4108Z6Z Transcriptional regulator ALFP_1996 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) ALFP_1998 ENOG4105BZS acriflavin resistance protein ALFP_1999 ENOG4105C1P efflux transporter, rnd family, mfp subunit ALFP_2000 ENOG4105D5T phosphonate abc transporter ALFP_2004 ENOG4105CHU acetyl-coa acetyltransferase ALFP_2005 ENOG4105CHU acetyl-coa acetyltransferase ALFP_2006 ENOG4105CHU acetyl-coa acetyltransferase ALFP_2008 ENOG4105CR4 methylisocitrate lyase ALFP_2010 ENOG4105EMY transcriptional regulator ALFP_2011 ENOG4105CXN decarboxylase ALFP_2015 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) ALFP_2016 ENOG4105VFG Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) ALFP_2017 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) ALFP_2019 ENOG4108UMN azlc family ALFP_2020 ENOG4105DR5 peptidase ALFP_2021 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) ALFP_2022 ENOG4107T6V glycerophosphoryl diester phosphodiesterase ALFP_2023 ENOG4105D6S protein involved in catabolism of external DNA ALFP_2024 ENOG4105FE9 pseudouridine synthase ALFP_2025 ENOG4105RUM Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4- hydroxybenzoate (4HB) for the ubiquinone pathway (By similarity) ALFP_2026 ENOG4105DXI Major Facilitator superfamily ALFP_2027 ENOG4105CV8 reductase ALFP_2028 ENOG4108YZA Nitrogen regulatory protein pii ALFP_2029 ENOG4105CUY Mechanosensitive ion channel ALFP_2030 ENOG4105CH7 arginosuccinase ALFP_2031 ENOG4105E2R ROK family ALFP_2033 ENOG4105CJP fad dependent oxidoreductase ALFP_2035 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) ALFP_2036 ENOG4108K5P (LipO)protein ALFP_2037 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) ALFP_2038 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) ALFP_2039 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) ALFP_2040 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) ALFP_2041 ENOG4105C7N Xanthine uracil vitamin C permease ALFP_2042 ENOG41080RH Thioredoxin ALFP_2046 ENOG4105C5H ABC transporter ALFP_2047 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A ALFP_2048 ENOG4108Z6B deaminase ALFP_2049 ENOG4105DA5 (ABC) transporter ALFP_2050 ENOG4105E3A (ABC) transporter ALFP_2052 ENOG4108VPT UPF0234 protein ALFP_2053 ENOG4105CEY Amp-dependent synthetase and ligase ALFP_2054 ENOG4107Z6W Protein CrcB homolog ALFP_2055 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) ALFP_2057 ENOG4105DHU Bile acid ALFP_2058 ENOG4107ZT5 Thiol disulfide interchange protein ALFP_2059 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase ALFP_2060 ENOG4105CG6 trap dicarboxylate transporter dctm subunit ALFP_2062 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) ALFP_2064 ENOG4107QJH Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) ALFP_2065 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) ALFP_2066 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) ALFP_2067 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) ALFP_2069 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) ALFP_2071 ENOG4108ZXC Two component transcriptional regulator, luxr family ALFP_2074 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase ALFP_2075 ENOG4105CNG UPF0061 protein ALFP_2077 ENOG4107S2Z UPF0761 membrane protein ALFP_2079 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) ALFP_2093 ENOG4105F0N pyrophosphate phospho-hydrolase ALFP_2095 ENOG4105ECF c-methyltransferase ALFP_2097 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) ALFP_2099 ENOG4108ZCF integral membrane protein ALFP_2100 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha ALFP_2101 ENOG4105CMV Succinyl-CoA synthetase subunit beta ALFP_2103 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) ALFP_2104 ENOG4105DZ2 Transcriptional regulator ALFP_2105 ENOG4108004 Modulates RecA activity (By similarity) ALFP_2106 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) ALFP_2110 ENOG4105CSH Transporter ALFP_2113 ENOG4105CEY Amp-dependent synthetase and ligase ALFP_2114 ENOG4105E9F Enoyl-CoA hydratase ALFP_2115 ENOG41062QD Membrane ALFP_2116 ENOG4107QN1 sodium solute ALFP_2117 ENOG4105C26 Dehydrogenase ALFP_2118 ENOG4105CXT aspartate transcarbamylase ALFP_2121 ENOG4105BZ4 penicillin-binding protein ALFP_2122 ENOG4107S52 alpha-2-macroglobulin domain protein ALFP_2124 ENOG4105EA8 2-Nitropropane dioxygenase ALFP_2125 ENOG4105D4P Coproporphyrinogen iii oxidase ALFP_2126 ENOG4105D65 subunit l ALFP_2127 ENOG4108ZE9 Monovalent cation H antiporter subunit C ALFP_2128 ENOG4107R4Z monovalent cation h antiporter subunit d ALFP_2130 ENOG4105W4C monovalent cation H antiporter subunit F ALFP_2133 ENOG4105CSH Transporter ALFP_2138 ENOG4105DFH Transport of potassium into the cell (By similarity) ALFP_2139 ENOG4105DHQ Histidine kinase ALFP_2140 ENOG4105XJC Two component transcriptional regulator (Winged helix family ALFP_2144 ENOG4108IJ6 ABC transporter ALFP_2145 ENOG4105ECW sulfate abc transporter ALFP_2146 ENOG4108I5D sulfate abc transporter ALFP_2147 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein ALFP_2150 ENOG4105VEQ Cold shock protein ALFP_2151 ENOG4105K70 DNA-binding protein ALFP_2153 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) ALFP_2154 ENOG4105Y7H Cytochrome ALFP_2155 ENOG4106P6N cytochrome d1 heme region ALFP_2156 ENOG4108UMR transcriptional regulator AsnC family ALFP_2157 ENOG4108ZGY Transcriptional regulator (AsnC family) ALFP_2158 ENOG4108UMR transcriptional regulator AsnC family ALFP_2161 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) ALFP_2164 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family ALFP_2165 ENOG4105C28 cystathionine ALFP_2166 ENOG4105C2N RNA methyltransferase TrmH family group 3 ALFP_2167 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) ALFP_2169 ENOG4105ETE Transcriptional regulator (LacI family ALFP_2170 ENOG4105E5Q amino acid AbC transporter ALFP_2171 ENOG4105E5Q amino acid AbC transporter ALFP_2172 ENOG4105CDA abc transporter atp-binding protein ALFP_2173 ENOG4105EAB amino acid AbC transporter ALFP_2175 ENOG4105DT1 RuBisCO catalyzes two reactions the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate ALFP_2178 ENOG4105Q26 Siderophore-interacting protein ALFP_2181 ENOG4107SCK Monooxygenase ALFP_2182 ENOG4105EHH Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue (By similarity) ALFP_2184 ENOG4105DUM transcriptional regulator, lysR family ALFP_2185 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) ALFP_2187 ENOG4108KAZ Involved in phosphonate degradation (By similarity) ALFP_2188 ENOG4105C4Y ABC transporter ALFP_2190 ENOG4108Z7F N-acetyltransferase ALFP_2192 ENOG4105CDZ Carboxymethylenebutenolidase (EC 3.1.1.45) ALFP_2193 ENOG4105VRT cytoplasmic protein ALFP_2194 ENOG4105CYM Glutathione S-transferase ALFP_2195 ENOG4105EUB pirin domain protein ALFP_2197 ENOG4107QPI nitrilase cyanide hydratase and apolipoprotein n-acyltransferase ALFP_2198 ENOG4105F27 Major Facilitator ALFP_2199 ENOG4105DJ2 Major Facilitator Superfamily ALFP_2200 ENOG4105R1U AraC Family Transcriptional Regulator ALFP_2201 ENOG4105DKK Benzoate ALFP_2203 ENOG4105E7W lamb ycsf family protein ALFP_2206 ENOG4105C7W Xanthine dehydrogenase ALFP_2208 ENOG4107QUY Guanine deaminase ALFP_2210 ENOG4105XJC Two component transcriptional regulator (Winged helix family ALFP_2212 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) ALFP_2213 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) ALFP_2214 ENOG4105VCC 30S ribosomal protein S21 ALFP_2215 ENOG4105DYA Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity) ALFP_2216 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis ALFP_2217 ENOG4105C49 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity) ALFP_2218 ENOG4105EPW hflc protein ALFP_2219 ENOG4107QJR hflk protein ALFP_2220 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) ALFP_2221 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) ALFP_2222 ENOG4105CIH Imidazole acetol-phosphate transaminase ALFP_2223 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) ALFP_2224 ENOG4105CNE Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) ALFP_2225 ENOG4105N21 Membrane ALFP_2226 ENOG4105CUT histidyl-tRNA synthetase ALFP_2227 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) ALFP_2229 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs ALFP_2230 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) ALFP_2232 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) ALFP_2233 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) ALFP_2234 ENOG4105K5M 30s ribosomal protein S16 ALFP_2235 ENOG41082K8 Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity) ALFP_2236 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) ALFP_2246 ENOG4105BZ7 extracellular solute-binding protein family 1 ALFP_2247 ENOG4105MWK D-amino acid dehydrogenase, small subunit ALFP_2249 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) ALFP_2250 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) ALFP_2251 ENOG4105K63 Thioredoxin ALFP_2252 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) ALFP_2253 ENOG4105D82 Glutamate dehydrogenase ALFP_2258 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component ALFP_2259 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component ALFP_2265 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) ALFP_2266 ENOG4105WPN DNA integration recombination invertion protein ALFP_2267 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit ALFP_2268 ENOG4105DS0 Transcriptional regulator, Crp Fnr family ALFP_2271 ENOG4105C58 cytochrome c oxidase accessory protein ccog ALFP_2275 ENOG4105EUH cytochrome C oxidase, cbb3-type, subunit i ALFP_2277 ENOG4105C59 p-type ATPase ALFP_2280 ENOG4105CSD Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) ALFP_2283 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) ALFP_2284 ENOG4107QPA Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides (By similarity) ALFP_2285 ENOG4105KJV Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) ALFP_2287 ENOG4108ZJI phenylacetic acid degradation protein ALFP_2288 ENOG4108UKI Enoyl-CoA hydratase ALFP_2289 ENOG4105C26 Dehydrogenase ALFP_2290 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) ALFP_2291 ENOG4108ZA2 phenylacetate-CoA oxygenase PaaJ subunit ALFP_2292 ENOG4105D9S phenylacetate-CoA oxygenase PaaI subunit ALFP_2293 ENOG4105N76 Phenylacetate-CoA oxygenase, subunit ALFP_2294 ENOG4105CRS phenylacetate-CoA oxygenase PaaG subunit ALFP_2296 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) ALFP_2297 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 ALFP_2298 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) ALFP_2300 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) ALFP_2304 ENOG4105D3R alkyl hydroperoxide reductase ALFP_2305 ENOG4105CSU acyl-Coa dehydrogenase ALFP_2306 ENOG4105C10 Electron transfer flavoprotein ALFP_2307 ENOG4105BZJ Electron transfer flavoprotein ALFP_2308 ENOG4105DGU Histone deacetylase ALFP_2310 ENOG4105CVE Lytic murein transglycosylase ALFP_2311 ENOG4105C6T cysteine synthase ALFP_2312 ENOG4105KQC Competence protein ALFP_2313 ENOG4105CUI Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity) ALFP_2314 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) ALFP_2315 ENOG4105CFV Tetratricopeptide repeat protein ALFP_2318 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) ALFP_2319 ENOG4105CAT Cytidine monophosphate kinase ALFP_2320 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase ALFP_2321 ENOG4105EVN Prephenate dehydrogenase ALFP_2322 ENOG4105CQC Prephenate dehydratase ALFP_2323 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) ALFP_2324 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) ALFP_2325 ENOG4105UYK outer membrane protein a ALFP_2326 ENOG4108HWB Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) ALFP_2327 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) ALFP_2328 ENOG4105DUM transcriptional regulator, lysR family ALFP_2330 ENOG4108Z4U Ferredoxin ALFP_2332 ENOG4105D05 Receptor ALFP_2337 ENOG4105F1N DNA alkylation repair ALFP_2340 ENOG4105CHM Aminotransferase ALFP_2342 ENOG4108UQ8 endoribonuclease L-psp ALFP_2343 ENOG4108IG5 Transcriptional regulator ALFP_2354 ENOG4105CYM Glutathione S-transferase ALFP_2361 ENOG4107SCJ type I restriction enzyme EcoKI subunit R ALFP_2369 ENOG4107QV7 Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) (By similarity) ALFP_2370 ENOG410829K Lysine exporter protein (Lyse ygga) ALFP_2375 ENOG4107QN1 sodium solute ALFP_2377 ENOG4105BZU Histidine kinase ALFP_2380 ENOG4107RIQ Sulfate adenylate transferase ALFP_2381 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) ALFP_2382 ENOG4105DHQ Histidine kinase ALFP_2384 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor ALFP_2387 ENOG4105EXG Transcriptional regulator ALFP_2388 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) ALFP_2389 ENOG4107T1C Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity) ALFP_2392 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) ALFP_2393 ENOG4105CGZ zinc metallopeptidase ALFP_2395 ENOG4105E2B Taurine dioxygenase ALFP_2396 ENOG4105K56 Transcriptional regulator ALFP_2399 ENOG4108YZA Nitrogen regulatory protein pii ALFP_2400 ENOG4105BZU Histidine kinase ALFP_2401 ENOG4105T86 cytochrome C ALFP_2402 ENOG4107QTF adenylosuccinate lyase ALFP_2403 ENOG4107MKT Stringent starvation protein a ALFP_2406 ENOG4105HF0 Membrane ALFP_2407 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) ALFP_2408 ENOG4105CQB FAD linked oxidase domain protein ALFP_2409 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) ALFP_2410 ENOG4105VCD cytoplasmic protein ALFP_2411 ENOG4105D22 carbon starvation protein ALFP_2416 ENOG4105C7K acetolactate synthase ALFP_2417 ENOG4105C26 Dehydrogenase ALFP_2418 ENOG4108Q27 Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate (By similarity) ALFP_2419 ENOG4105CHR reductase ALFP_2420 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) ALFP_2421 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component ALFP_2422 ENOG4105D7T ABC transporter ALFP_2425 ENOG4108Z9W Outer membrane porin ALFP_2428 ENOG4105EV8 ectoine hydroxylase ALFP_2429 ENOG4108Z6K Catalyzes the circularization of gamma-N-acetyl- alpha,gamma-diaminobutyric acid (ADABA) to ectoine (1,4,5,6- tetrahydro-2-methyl-4-pyrimidine carboxylic acid), which is an excellent osmoprotectant (By similarity) ALFP_2430 ENOG4108JPW Aminotransferase ALFP_2431 ENOG4108Z24 l-2,4-diaminobutyric acid acetyltransferase ALFP_2432 ENOG41090MY MarR family Transcriptional regulator ALFP_2434 ENOG4105D1U peptidase U62 modulator of DNA gyrase ALFP_2435 ENOG4105VFQ Histone family protein nucleoid-structuring protein H-NS ALFP_2437 ENOG4105CD8 aminopeptidase N ALFP_2438 ENOG4105CZI D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 ALFP_2439 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein ALFP_2441 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) ALFP_2443 ENOG4105D7A ATP-binding protein ALFP_2444 ENOG4105CDY transcriptional regulatory protein ALFP_2445 ENOG4105C12 Phosphoribosylglycinamide synthetase ALFP_2446 ENOG4105DBS Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity) ALFP_2447 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) ALFP_2448 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) ALFP_2449 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) ALFP_2450 ENOG4108Z03 MAF-like protein ALFP_2451 ENOG4108KHN disulfide isomerase, thiol-disulfide oxidase ALFP_2454 ENOG4108ZJT translation initiation factor, Sui1 ALFP_2456 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase ALFP_2457 ENOG4108RXX maleylacetoacetate isomerase ALFP_2458 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) ALFP_2459 ENOG4108YZY peptidylprolyl cis-trans isomerase ALFP_2460 ENOG4105W5Q DNA repair protein (RadC ALFP_2461 ENOG4106KNT transcriptional regulator ALFP_2462 ENOG4105C54 Major Facilitator superfamily ALFP_2464 ENOG4105CSP Major Facilitator Superfamily ALFP_2465 ENOG4105NRA 50s ribosomal protein l31 type b ALFP_2467 ENOG4107QI1 Mate efflux family protein ALFP_2468 ENOG4108IJ7 Glycine betaine ALFP_2469 ENOG4108HQS Glycine betaine ALFP_2471 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase ALFP_2473 ENOG4105C2C drug resistance transporter, Bcr CflA ALFP_2474 ENOG4105KDC 50s ribosomal protein l28 ALFP_2475 ENOG4105W0E 50S ribosomal protein L33 ALFP_2476 ENOG4105C8T Leucyl-tRNA synthetase ALFP_2478 ENOG4105DJF DNA polymerase III, delta' subunit ALFP_2479 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) ALFP_2481 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) ALFP_2484 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) ALFP_2486 ENOG4105XX3 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) ALFP_2487 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) ALFP_2493 ENOG4109025 Glyoxalase Bleomycin resistance protein (Dioxygenase ALFP_2494 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) ALFP_2499 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase ALFP_2500 ENOG4108594 Permease of the drug metabolite transporter ALFP_2501 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) ALFP_2504 ENOG4105K4H Nlp p60 protein ALFP_2506 ENOG4107R11 Transcriptional regulator ALFP_2507 ENOG4105C26 Dehydrogenase ALFP_2508 ENOG4105SKE transcriptional Regulator LysR family ALFP_2510 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) ALFP_2512 ENOG4108XRP Membrane ALFP_2513 ENOG4105D7W serine acetyltransferase ALFP_2516 ENOG41071DT Involved in DNA repair and RecF pathway recombination (By similarity) ALFP_2517 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) ALFP_2518 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) ALFP_2519 ENOG4105C3F Signal peptidase i ALFP_2520 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) ALFP_2521 ENOG4105C0H protease ALFP_2524 ENOG4105EMN RNA polymerase sigma factor ALFP_2526 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) ALFP_2528 ENOG4105CHR reductase ALFP_2529 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase ALFP_2530 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) ALFP_2531 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) ALFP_2532 ENOG4105VGS 50s ribosomal protein l32 ALFP_2533 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein ALFP_2534 ENOG4108UHJ MAF-like protein ALFP_2535 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) ALFP_2536 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase ALFP_2537 ENOG4105DQ2 Is probably involved in the electron transfer between its heme and the molybdenum cofactor of the reductase catalytic subunit YedY (By similarity) ALFP_2538 ENOG4105CCD The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity) ALFP_2539 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) ALFP_2540 ENOG4105EI2 Pseudouridine synthase ALFP_2541 ENOG4105C03 ribonuclease ALFP_2542 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) ALFP_2543 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) ALFP_2544 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) ALFP_2545 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) ALFP_2547 ENOG4107RH7 Nicotinate phosphoribosyltransferase ALFP_2548 ENOG4108Z4U Ferredoxin ALFP_2550 ENOG4108R3D Electron transport complex ALFP_2551 ENOG4105CSM endonuclease III ALFP_2552 ENOG4108JJ8 (ABC) transporter ALFP_2553 ENOG4105EIF outer membrane protein W ALFP_2554 ENOG4108IV0 ABC, transporter ALFP_2555 ENOG4105C0Z ABC transporter ALFP_2559 ENOG4105E0X reductase ALFP_2560 ENOG4107835 probably involved in intracellular septation (By similarity) ALFP_2562 ENOG4107TF3 peptidylprolyl cis-trans isomerase ALFP_2563 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) ALFP_2565 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) ALFP_2566 ENOG4108J8Q Catalyzes the facilitated diffusion of 2-acyl-glycero-3- phosphoethanolamine (2-acyl-GPE) into the cell (By similarity) ALFP_2567 ENOG4108UN4 phage SPO1 DNA polymerase-related protein ALFP_2568 ENOG41072GX Peptidase M22 Glycoprotease ALFP_2569 ENOG4105DPZ Two component transcriptional regulator (Winged helix family ALFP_2570 ENOG4105E0F Histidine kinase ALFP_2572 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) ALFP_2573 ENOG4108JA2 transcriptioN-repair coupling factor ALFP_2574 ENOG4105EAC phosphoserine phosphatase ALFP_2577 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) ALFP_2578 ENOG4105C8S subunit m ALFP_2580 ENOG4105M5H NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) ALFP_2581 ENOG4105DF2 NADH dehydrogenase subunit j ALFP_2582 ENOG4105P3U NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) ALFP_2583 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) ALFP_2584 ENOG4108IEH NADH dehydrogenase subunit g ALFP_2587 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) ALFP_2588 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain ALFP_2589 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) ALFP_2590 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain ALFP_2592 ENOG4108Z9W Outer membrane porin ALFP_2593 ENOG4107EJC Preprotein translocase subunit SecG ALFP_2594 ENOG4105CP7 Triose-phosphate isomerase ALFP_2595 ENOG4105CB2 alcohol dehydrogenase ALFP_2597 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) ALFP_2598 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) ALFP_2599 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase ALFP_2600 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase ALFP_2601 ENOG4108ZP8 Acetolactate synthase small subunit ALFP_2602 ENOG4105C7K acetolactate synthase ALFP_2604 ENOG4105D1Q UPF0246 protein ALFP_2609 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) ALFP_2610 ENOG4105D1H recombination factor protein RarA ALFP_2611 ENOG4107Y7W Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity) ALFP_2612 ENOG4105CNU cell division protein FtsK ALFP_2613 ENOG4105C3M thioredoxin reductase ALFP_2615 ENOG4105WAP TPR repeat-containing protein ALFP_2621 ENOG4105EBR Carboxylesterase ALFP_2622 ENOG4108KC1 acyl-Coa dehydrogenase ALFP_2626 ENOG4106RE7 Cytochrome ALFP_2627 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) ALFP_2631 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family ALFP_2653 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) ALFP_2654 ENOG4105CFG Acts as a chaperone (By similarity) ALFP_2655 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ ALFP_2656 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) ALFP_2657 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) ALFP_2658 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) ALFP_2659 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) ALFP_2660 ENOG41090R7 Ferric uptake ALFP_2661 ENOG4105YRI Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) ALFP_2662 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) ALFP_2667 ENOG41079KZ Major Facilitator Superfamily ALFP_2670 ENOG4105D4A Cell wall formation (By similarity) ALFP_2674 ENOG4105ENJ RND efflux system, outer membrane lipoprotein ALFP_2679 ENOG4105CNM Receptor ALFP_2680 ENOG4105C2C drug resistance transporter, Bcr CflA ALFP_2683 ENOG4105NIV Esterase ALFP_2687 ENOG4105C0A alcohol dehydrogenase ALFP_2688 ENOG4108IV0 ABC, transporter ALFP_2689 ENOG4108IUZ ABC transporter ALFP_2691 ENOG4105C32 Amino acid ABC transporter (Permease) ALFP_2693 ENOG4105C26 Dehydrogenase ALFP_2694 ENOG4108FUF Transcriptional regulator, IclR family ALFP_2695 ENOG4105C1J atp-dependent rna helicase ALFP_2696 ENOG4108W5M transcriptional regulator ALFP_2697 ENOG4105FUY alpha subunit ALFP_2698 ENOG4108SBK dioxygenase, subunit beta ALFP_2701 ENOG4108DNI pyridine nucleotide-disulfide oxidoreductase ALFP_2703 ENOG4107UB2 Alpha beta hydrolase fold ALFP_2704 ENOG4105IKQ hydratase ALFP_2705 ENOG4105DIV Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD( ) and coenzyme A. Is the final enzyme in the meta- cleavage pathway for the degradation of aromatic compounds (By similarity) ALFP_2706 ENOG4105DF3 Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta-cleavage pathway for the degradation of aromatic compounds (By similarity) ALFP_2707 ENOG4108SC4 )-transporter ALFP_2710 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) ALFP_2711 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family ALFP_2712 ENOG4105DXI Major Facilitator superfamily ALFP_2713 ENOG4107EXU Short-chain dehydrogenase reductase Sdr ALFP_2716 ENOG4105CHU acetyl-coa acetyltransferase ALFP_2717 ENOG4105CHR reductase ALFP_2719 ENOG4105CMI transporter ALFP_2720 ENOG4105CJ1 ABC, transporter ALFP_2721 ENOG4105D0S secretion protein (HlyD ALFP_2723 ENOG4105D1N poly(r)-hydroxyalkanoic acid synthase, class ALFP_2725 ENOG4105EX9 Membrane ALFP_2726 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) ALFP_2727 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) ALFP_2732 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) ALFP_2735 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) ALFP_2738 ENOG4108Z4X TRANSCRIPTIONal ALFP_2741 ENOG4105BZS acriflavin resistance protein ALFP_2745 ENOG4107TSX ABC branched chain amino acid family transporter periplasmic ligand binding protein ALFP_2746 ENOG4105IW1 AmiS UreI transporter ALFP_2752 ENOG4105EUH cytochrome C oxidase, cbb3-type, subunit i ALFP_2753 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family ALFP_2755 ENOG4105EVZ LysR family transcriptional regulator ALFP_2756 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) ALFP_2757 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) ALFP_2758 ENOG4105EQR Transposase IS116 IS110 IS902 ALFP_2761 ENOG4105HSS phospholipase C ALFP_2767 ENOG4108C33 Resolvase ALFP_2768 ENOG4105D7Q type ii secretion system ALFP_2769 ENOG4107QHF type ii secretion system protein e ALFP_2770 ENOG4105GVR general secretion pathway protein D ALFP_2778 ENOG4108VAU general secretion pathway protein G ALFP_2780 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) ALFP_2783 ENOG4108IJ0 Aspartate ammonia-lyase ALFP_2785 ENOG41082F9 transcriptional regulator ALFP_2788 ENOG4108R4Z Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity) ALFP_2789 ENOG4105DWA May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate ALFP_2793 ENOG41069M3 Transcriptional regulator ALFP_2797 ENOG4105C1J atp-dependent rna helicase ALFP_2801 ENOG4105DNZ Alpha Beta Hydrolase ALFP_2802 ENOG4105ERG peptidase m48, ste24p ALFP_2807 ENOG4105D0A hydroxylase ALFP_2808 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) ALFP_2809 ENOG4105VY0 Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters (By similarity) ALFP_2811 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) ALFP_2812 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) ALFP_2814 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) ALFP_2816 ENOG4105EKE dihydroorotase ALFP_2822 ENOG4105KHC sulfurtransferase ALFP_2823 ENOG41066VF YeeE YedE family protein ALFP_2826 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) ALFP_2827 ENOG4105W2Z cytochrome C, class I ALFP_2833 ENOG4105D38 putrescine abc transporter ALFP_2834 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) ALFP_2835 ENOG4107QKW extracellular solute-binding protein family 1 ALFP_2836 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase ALFP_2839 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) ALFP_2840 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) ALFP_2841 ENOG4107YD3 Thioesterase ALFP_2842 ENOG4105E02 MotA TolQ exbB proton channel ALFP_2843 ENOG4105M8F Biopolymer transport protein exbD tolR ALFP_2845 ENOG4107R6Y Involved in the TonB-independent uptake of proteins (By similarity) ALFP_2846 ENOG4105KCK Peptidoglycan-associated lipoprotein ALFP_2848 ENOG4108J2P Alpha beta hydrolase fold ALFP_2851 ENOG4107QI1 Mate efflux family protein ALFP_2854 ENOG4105UIB (ABC) transporter ALFP_2855 ENOG4105C2J ABC transporter ALFP_2858 ENOG4108NIW Leucine export protein LeuE ALFP_2859 ENOG4105CYC Transferase ALFP_2860 ENOG4105CMU LysR family (Transcriptional regulator ALFP_2861 ENOG4108JU3 Alkyl hydroperoxide reductase ALFP_2864 ENOG4105T38 integral membrane protein ALFP_2866 ENOG4105C11 sulfate adenylyltransferase), subunit 2 ALFP_2869 ENOG4105C26 Dehydrogenase ALFP_2870 ENOG4105CJP fad dependent oxidoreductase ALFP_2871 ENOG4105E32 cytoplasmic protein ALFP_2872 ENOG4105ETT transcriptional Regulator, LysR family ALFP_2876 ENOG4105CC0 LysR family Transcriptional regulator ALFP_2877 ENOG4105C2I pirin domain protein ALFP_2879 ENOG4105BZU Histidine kinase ALFP_2883 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) ALFP_2884 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) ALFP_2885 ENOG41080IJ Diacylglycerol kinase ALFP_2886 ENOG4105SKN orotidine 5''-phosphate decarboxylase ALFP_2890 ENOG4107HP6 Transcriptional regulator ALFP_2892 ENOG4108ZAI phosphatidylglycerophosphatase a ALFP_2893 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) ALFP_2894 ENOG4107YIM Involved in the transcription termination process (By similarity) ALFP_2895 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) ALFP_2900 ENOG4106H78 methyltransferase ALFP_2901 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) ALFP_2902 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding ALFP_2908 ENOG4108T7K Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Increasing levels of c-di-GMP lead to decreased motility (By similarity) ALFP_2911 ENOG4108UAU isochorismatase ALFP_2914 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding ALFP_2915 ENOG4108XHQ (2Fe-2S)-binding domain protein ALFP_2916 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding ALFP_2918 ENOG4108IV0 ABC, transporter ALFP_2919 ENOG4105C0Z ABC transporter ALFP_2924 ENOG4105BZU Histidine kinase ALFP_2931 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) ALFP_2932 ENOG4105FDP GntR family transcriptional regulator ALFP_2934 ENOG4107RZC phospholipase d ALFP_2936 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) ALFP_2937 ENOG4107P0T Selenium-dependent molybdenum hydroxylase system protein, YqeB family ALFP_2938 ENOG4105CG6 trap dicarboxylate transporter dctm subunit ALFP_2940 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component ALFP_2946 ENOG4105CH5 extracellular solute-binding protein, family 7 ALFP_2952 ENOG4108UAU isochorismatase ALFP_2957 ENOG4105E0A ABC, transporter ALFP_2958 ENOG4105EHG Permease protein ALFP_2960 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) ALFP_2961 ENOG4105CRW Short chain fatty acid transporter ALFP_2963 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) ALFP_2965 ENOG4108JDX DNA polymerase iii, epsilon subunit ALFP_2966 ENOG4105BZS acriflavin resistance protein ALFP_2967 ENOG410624X efflux transporter, rnd family, mfp subunit ALFP_2968 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) ALFP_2969 ENOG4105D1A Methyltransferase ALFP_2970 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) ALFP_2971 ENOG4105E9H Lytic Murein transglycosylase ALFP_2972 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH ALFP_2974 ENOG4107BVJ 4,5-dihydroxyphthalate decarboxylase ALFP_2975 ENOG4108HR6 Dehydrogenase ALFP_2982 ENOG4105CK2 sodium dicarboxylate symporter ALFP_2985 ENOG4105C72 UPF0176 protein ALFP_2990 ENOG4108UIN ybak prolyl-trna synthetase associated region ALFP_2991 ENOG4108JUA Transcriptional regulator ALFP_2993 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) ALFP_2994 ENOG4105C1K alpha-alpha-trehalose-phosphate synthase ALFP_2997 ENOG4105CYX Short-chain dehydrogenase reductase Sdr ALFP_3001 ENOG4108T2C cysteine dioxygenase type I ALFP_3003 ENOG4105CD5 CoA-binding domain protein ALFP_3005 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family ALFP_3007 ENOG4105E9F Enoyl-CoA hydratase ALFP_3010 ENOG4105CIS alcohol dehydrogenase ALFP_3011 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase ALFP_3012 ENOG4105JQN Transcriptional regulator ALFP_3013 ENOG4108KAZ Involved in phosphonate degradation (By similarity) ALFP_3014 ENOG4105C0A alcohol dehydrogenase ALFP_3023 ENOG4105EAB amino acid AbC transporter ALFP_3026 ENOG4105K89 arsenate reductase ALFP_3027 ENOG4105CAU Arsenical resistance protein, ArsH ALFP_3028 ENOG4105XJC Two component transcriptional regulator (Winged helix family ALFP_3029 ENOG4105DHQ Histidine kinase ALFP_3045 ENOG4105CMA conjugation trbi family protein ALFP_3063 ENOG4108KU3 Integrase ALFP_3064 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) ALFP_3065 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) ALFP_3066 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) ALFP_3067 ENOG4108V1U phospholipid-binding protein ALFP_3068 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) ALFP_3069 ENOG4105DR5 peptidase ALFP_3070 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) ALFP_3071 ENOG4108YX9 iron--sulfur cluster insertion protein erpA ALFP_3073 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase ALFP_3074 ENOG4108UJD 30S ribosomal protein S9 ALFP_3075 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) ALFP_3076 ENOG4105CH5 extracellular solute-binding protein, family 7 ALFP_3077 ENOG4105CMS peptidase U62, modulator of DNA gyrase ALFP_3078 ENOG4105N42 UPF0307 protein ALFP_3081 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic ALFP_3083 ENOG4108ZXC Two component transcriptional regulator, luxr family ALFP_3084 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) ALFP_3086 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) ALFP_3087 ENOG4105C2W permease ALFP_3088 ENOG4108XEP Alpha Beta Hydrolase Fold protein ALFP_3090 ENOG4105CHR reductase ALFP_3092 ENOG4108M0I Transcriptional regulator ALFP_3093 ENOG4108VWS Yaeq family ALFP_3095 ENOG4105J0Q Transcriptional regulator ALFP_3098 ENOG4108VIA integral membrane protein ALFP_3099 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) ALFP_3100 ENOG4108XTF Outer Membrane Lipoprotein ALFP_3103 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) ALFP_3104 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase ALFP_3105 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein ALFP_3106 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) ALFP_3108 ENOG4105DFU Cell wall formation (By similarity) ALFP_3109 ENOG4105IPS esterase ALFP_3112 ENOG4105E2X shikimate dehydrogenase ALFP_3113 ENOG4108VKV Monofunctional biosynthetic peptidoglycan transglycosylase ALFP_3115 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) ALFP_3116 ENOG4108Z20 Acyl-transferase ALFP_3117 ENOG4107Y66 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) ALFP_3118 ENOG4108UJU UPF0301 protein ALFP_3120 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) ALFP_3122 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase ALFP_3123 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase ALFP_3124 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase ALFP_3128 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) ALFP_3130 ENOG4105VDW Csbd family ALFP_3132 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) ALFP_3133 ENOG4105K46 50S ribosomal protein l27 ALFP_3134 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control ALFP_3135 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) ALFP_3140 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) ALFP_3141 ENOG4105CDV Ompa motb domain protein ALFP_3143 ENOG4105CDA abc transporter atp-binding protein ALFP_3144 ENOG4105DRP amino acid AbC transporter ALFP_3145 ENOG4105EZ7 amino acid ABC transporter ALFP_3147 ENOG4105CAK Cell division ATP-binding protein ftsE ALFP_3148 ENOG4105CRP Part of the ABC transporter FtsEX involved in ALFP_3149 ENOG4105CEN a g-specific adenine glycosylase ALFP_3150 ENOG4105CNI cell division protein FtsW ALFP_3151 ENOG4105CJN penicillin-binding protein ALFP_3153 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) ALFP_3154 ENOG4105DFF Rod shape-determining protein mreb ALFP_3155 ENOG41080G2 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) ALFP_3156 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) ALFP_3157 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) ALFP_3159 ENOG4105EJC lysr family transcriptional regulator ALFP_3160 ENOG4105MGM doxx family ALFP_3161 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b ALFP_3165 ENOG4105DSQ Nitric oxide reductase ALFP_3169 ENOG4105D6U Sodium Glutamate Symporter ALFP_3170 ENOG4105EAH synthase ALFP_3172 ENOG4105M6F mutator MutT protein ALFP_3173 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) ALFP_3174 ENOG4105ENJ RND efflux system, outer membrane lipoprotein ALFP_3178 ENOG4105DHA Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity (By similarity) ALFP_3179 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) ALFP_3182 ENOG4107R03 Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) ALFP_3183 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) ALFP_3185 ENOG4105C0R drug resistance transporter emrb qaca subfamily ALFP_3187 ENOG4105C3R Methionine synthase ALFP_3188 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) ALFP_3189 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) ALFP_3190 ENOG4105CNM Receptor ALFP_3192 ENOG4108SF5 RNA Polymerase ALFP_3194 ENOG4108Z9W Outer membrane porin ALFP_3196 ENOG4107QUT magnesium and cobalt transport protein CorA ALFP_3198 ENOG4107QUT magnesium and cobalt transport protein CorA ALFP_3202 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) ALFP_3203 ENOG4105DWF phosphomethylpyrimidine kinase ALFP_3204 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) ALFP_3205 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) ALFP_3206 ENOG4105DFG type I secretion outer membrane protein ALFP_3207 ENOG4107Z67 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) ALFP_3209 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) ALFP_3212 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) ALFP_3213 ENOG4105CK6 Two component transcriptional regulator (Winged helix family ALFP_3214 ENOG4105BZU Histidine kinase ALFP_3216 ENOG4105P4J Allophanate hydrolase, subunit 1 ALFP_3218 ENOG4105C7B Threonine dehydratase ALFP_3219 ENOG4105W39 Membrane ALFP_3223 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) ALFP_3225 ENOG4108JJ8 (ABC) transporter ALFP_3226 ENOG4108JJ9 ABC, transporter ALFP_3228 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii ALFP_3229 ENOG4105C4M (Ubiquinol oxidase) subunit I ALFP_3231 ENOG4105C2X Arabinose 5-phosphate isomerase ALFP_3232 ENOG4108Z4R 3-deoxy-d-manno-octulosonate 8-phosphate phosphatase ALFP_3235 ENOG4108IUZ ABC transporter ALFP_3236 ENOG41080QH sigma 54 modulation protein ribosomal protein S30EA ALFP_3237 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN ALFP_3238 ENOG4105D1C Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) ALFP_3239 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) ALFP_3241 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) ALFP_3242 ENOG41082RQ UPF0102 protein ALFP_3243 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) ALFP_3246 ENOG4105CAS nag kinase ALFP_3250 ENOG4105D06 uba thif-type nad fad binding protein ALFP_3251 ENOG4105CN1 protease ALFP_3253 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) ALFP_3254 ENOG4107YZP Rhodanese domain protein ALFP_3256 ENOG4105IX2 One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity) ALFP_3257 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase ALFP_3259 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) ALFP_3260 ENOG4105MJ2 Competence protein ALFP_3261 ENOG4106T9E Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) ALFP_3262 ENOG4105D05 Receptor ALFP_3263 ENOG4105XJC Two component transcriptional regulator (Winged helix family ALFP_3265 ENOG410908U Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) ALFP_3266 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family ALFP_3269 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B ALFP_3271 ENOG4108Z0R Transferase ALFP_3276 ENOG4108IY8 ABC, transporter ALFP_3282 ENOG4105CJT Mannose-1-phosphate guanylyltransferase ALFP_3287 ENOG4108MX3 Polysaccharide Biosynthesis Protein ALFP_3288 ENOG4105C1B dTDP-glucose 4-6-dehydratase ALFP_3289 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) ALFP_3290 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase ALFP_3292 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) ALFP_3293 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) ALFP_3294 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) ALFP_3295 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) ALFP_3296 ENOG4107S15 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) ALFP_3297 ENOG4107Z6K F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) ALFP_3298 ENOG4105KY6 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) ALFP_3299 ENOG4107RAZ it plays a direct role in the translocation of protons across the membrane (By similarity) ALFP_3301 ENOG4105E39 Enoyl-CoA hydratase ALFP_3304 ENOG4105CB3 Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity) ALFP_3305 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase ALFP_3307 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) ALFP_3309 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) ALFP_3314 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) ALFP_3315 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) ALFP_3316 ENOG4105CNM Receptor ALFP_3323 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) ALFP_3325 ENOG4108KK1 membrane protein AbrB duplication ALFP_3329 ENOG4105GR3 Histidine kinase ALFP_3332 ENOG4105CSH Transporter ALFP_3333 ENOG4105ES4 Nitrilase ALFP_3337 ENOG4105E2Y ABC, transporter ALFP_3342 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) ALFP_3343 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) ALFP_3344 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein ALFP_3345 ENOG4108MG3 formate dehydrogenase ALFP_3347 ENOG4105C1Y Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis (By similarity) ALFP_3348 ENOG4105EM7 Selenocysteine-specific translation elongation factor ALFP_3350 ENOG4108S8N class II Aldolase ALFP_3353 ENOG4107RNH Outer membrane receptor FepA ALFP_3355 ENOG4105CNM Receptor ALFP_3356 ENOG4105D4F Synthesizes selenophosphate from selenide and ATP (By similarity) ALFP_3359 ENOG4108KAM Transcriptional regulator ALFP_3360 ENOG4105CR7 Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA (By similarity) ALFP_3362 ENOG4105EQJ Nitrous-oxide reductase is part of a bacterial respiratory system which is activated under anaerobic conditions in the presence of nitrate or nitrous oxide (By similarity) ALFP_3364 ENOG4105CIG ABC transporter ALFP_3365 ENOG4108T0W nitrous oxide maturation protein NosY ALFP_3368 ENOG4107QP8 phosphohexose isomerase ALFP_3381 ENOG4108IJ1 Dehydrogenase ALFP_3383 ENOG4105ECX polysaccharide export ALFP_3385 ENOG41090SZ ABC-2 type transporter ALFP_3387 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) ALFP_3390 ENOG4105C2W permease ALFP_3391 ENOG4105T38 integral membrane protein ALFP_3392 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family ALFP_3393 ENOG4107Y9U Membrane ALFP_3397 ENOG4108ZG0 Ompa motb domain protein ALFP_3414 ENOG4105CS6 Rhs element vgr protein ALFP_3416 ENOG4105CHU acetyl-coa acetyltransferase ALFP_3420 ENOG4105DHJ ABC, transporter ALFP_3421 ENOG4105CY3 ABC transporter, permease ALFP_3422 ENOG4107PE3 Mammalian cell entry related domain protein ALFP_3425 ENOG4105DA5 (ABC) transporter ALFP_3426 ENOG4105E3A (ABC) transporter ALFP_3428 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) ALFP_3429 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) ALFP_3430 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) ALFP_3431 ENOG4105ECC imidazole-glycerol-phosphate dehydratase ALFP_3433 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase ALFP_3434 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) ALFP_3435 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase ALFP_3436 ENOG4105KPZ phosphoribosyl-atp pyrophosphatase ALFP_3437 ENOG4107YU2 histidine triad (hIT) protein ALFP_3438 ENOG4105WKS Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) ALFP_3441 ENOG4105C0H protease ALFP_3442 ENOG4107QNR UPF0135 protein ALFP_3443 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) ALFP_3444 ENOG4108R5F Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) ALFP_3445 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) ALFP_3446 ENOG4105EIX cytochrome c1 ALFP_3447 ENOG4107MKT Stringent starvation protein a ALFP_3448 ENOG4105KB2 stringent starvation protein b ALFP_3449 ENOG4105ECW sulfate abc transporter ALFP_3450 ENOG4108I5D sulfate abc transporter ALFP_3451 ENOG4108J2H Sulfate ABC transporter periplasmic sulfate-binding protein ALFP_3455 ENOG4107SJI Dehydrogenase ALFP_3458 ENOG4105CMJ mandelate racemase muconate lactonizing ALFP_3460 ENOG4105FUY alpha subunit ALFP_3463 ENOG4105C5I Dehydrogenase ALFP_3465 ENOG4105CG6 trap dicarboxylate transporter dctm subunit ALFP_3467 ENOG4105CH5 extracellular solute-binding protein, family 7 ALFP_3468 ENOG4105EXW epimerase dehydratase ALFP_3471 ENOG4105C01 Dihydroxy-acid dehydratase ALFP_3472 ENOG4108WYP Transcriptional regulator ALFP_3473 ENOG4108XM1 transcriptional regulator AsnC family ALFP_3475 ENOG4105HJ8 Catalyzes the oxidative cleavage of the L-tryptophan (L- Trp) pyrrole ring (By similarity) ALFP_3479 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) ALFP_3480 ENOG4105CV8 reductase ALFP_3482 ENOG4107QM5 aconitate hydratase ALFP_3483 ENOG4105BZU Histidine kinase ALFP_3484 ENOG4105DHI Methyltransferase ALFP_3490 ENOG4105F04 LysR family Transcriptional regulator ALFP_3491 ENOG4105CSH Transporter ALFP_3492 ENOG4105CHR reductase ALFP_3494 ENOG4105EUB pirin domain protein ALFP_3495 ENOG4105CHJ isochorismatase hydrolase ALFP_3496 ENOG4105EUB pirin domain protein ALFP_3497 ENOG4105JQN Transcriptional regulator ALFP_3498 ENOG4105VDW Csbd family ALFP_3499 ENOG4105K3G Periplasmic Protein ALFP_3501 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family ALFP_3505 ENOG4105CNM Receptor ALFP_3509 ENOG4108SF5 RNA Polymerase ALFP_3510 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) ALFP_3511 ENOG4108YXU transcriptional regulator AsnC family ALFP_3514 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) ALFP_3517 ENOG4105CV4 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity) ALFP_3518 ENOG4105BZ9 Cytochrome C oxidase, subunit I ALFP_3521 ENOG4107QS1 Cytochrome C Oxidase, Subunit III ALFP_3526 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) ALFP_3529 ENOG4107RNH Outer membrane receptor FepA ALFP_3530 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) ALFP_3532 ENOG4107QPD alcohol dehydrogenase ALFP_3533 ENOG4105DZQ phospholipase D Transphosphatidylase ALFP_3534 ENOG4105X23 Endonuclease Exonuclease phosphatase ALFP_3535 ENOG4105C9M aspartyl-trna synthetase ALFP_3539 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family ALFP_3541 ENOG4105CI2 imidazolone-5-propionate hydrolase ALFP_3543 ENOG4105C84 Histidine ammonia-lyase ALFP_3544 ENOG4105CGP Urocanate hydratase ALFP_3548 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase ALFP_3550 ENOG4105F27 Major Facilitator ALFP_3552 ENOG4108Z6Z Transcriptional regulator ALFP_3558 ENOG4105CYM Glutathione S-transferase ALFP_3563 ENOG4105CGF Aromatic amino acid aminotransferase ALFP_3565 ENOG4105M2Z protein tyrosine serine phosphatase ALFP_3566 ENOG4105CY0 Metallo-Beta-Lactamase ALFP_3570 ENOG4105CIF Ornithine Cyclodeaminase ALFP_3582 ENOG4105DRR Transcriptional regulator, GntR family ALFP_3583 ENOG4105EJ2 Transcriptional regulator ALFP_3584 ENOG4105C2C drug resistance transporter, Bcr CflA ALFP_3587 ENOG4105CZM Major Facilitator ALFP_3588 ENOG4105KME endoribonuclease L-psp ALFP_3590 ENOG4105ERH Fumarylacetoacetate hydrolase ALFP_3591 ENOG4105C6F GntR Family Transcriptional Regulator ALFP_3592 ENOG4108UUM single-stranded DNA-binding protein ALFP_3593 ENOG4107RDB Major Facilitator ALFP_3595 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein ALFP_3596 ENOG4105D49 3-dehydroquinate synthase ALFP_3597 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) ALFP_3598 ENOG4108JQC penicillin-binding protein 1A ALFP_3600 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) ALFP_3601 ENOG4105BZU Histidine kinase ALFP_3603 ENOG4105CRE cytochrome C ALFP_3604 ENOG4105EBH Required during biogenesis of c-type cytochromes (cytochrome c6 and cytochrome f) at the step of heme attachment (By similarity) ALFP_3606 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) ALFP_3607 ENOG4105D52 delta-aminolevulinic acid dehydratase ALFP_3608 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) ALFP_3612 ENOG4105EQP Catalyzes the pyrimidine ring opening between N-3 and C- 4 by an unusual flavin hydroperoxide-catalyzed mechanism to yield ureidoacrylate peracid. It cleaves pyrmidine rings directly by adding oxygen atoms, making a toxic ureidoacrylate peracid product which can be spontaneously reduced to ureidoacrylate (By similarity) ALFP_3613 ENOG4108ZT0 50S ribosomal protein l17 ALFP_3614 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) ALFP_3615 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) ALFP_3616 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) ALFP_3617 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits ALFP_3619 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) ALFP_3620 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) ALFP_3621 ENOG4105VPB 50S ribosomal protein L30 ALFP_3622 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) ALFP_3623 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) ALFP_3624 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) ALFP_3625 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) ALFP_3626 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) ALFP_3627 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits ALFP_3628 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) ALFP_3629 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) ALFP_3634 ENOG4107QZV Type I secretion membrane fusion protein ALFP_3637 ENOG4105DFG type I secretion outer membrane protein ALFP_3640 ENOG4107QPN acyl-Coa dehydrogenase ALFP_3641 ENOG4105CHU acetyl-coa acetyltransferase ALFP_3642 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase ALFP_3643 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation ALFP_3646 ENOG4105CEY Amp-dependent synthetase and ligase ALFP_3647 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) ALFP_3648 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) ALFP_3649 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) ALFP_3652 ENOG4105D7T ABC transporter ALFP_3656 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal ALFP_3657 ENOG41084PQ 50s ribosomal protein l29 ALFP_3658 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) ALFP_3659 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) ALFP_3660 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) ALFP_3661 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) ALFP_3662 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity ALFP_3663 ENOG41080KG One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) ALFP_3664 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) ALFP_3665 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) ALFP_3667 ENOG4108IJ7 Glycine betaine ALFP_3668 ENOG4108HQS Glycine betaine ALFP_3669 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) ALFP_3670 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) ALFP_3671 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) ALFP_3672 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) ALFP_3673 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) ALFP_3680 ENOG4107QR0 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) ALFP_3681 ENOG4107QIH DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) ALFP_3682 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) ALFP_3683 ENOG4108VZM 50s ribosomal protein L10 ALFP_3684 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) ALFP_3685 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) ALFP_3688 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) ALFP_3690 ENOG4105FA0 parb-like partition protein ALFP_3691 ENOG4107QJE Chromosome Partitioning Protein ALFP_3693 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) ALFP_3694 ENOG4105CHM Aminotransferase ALFP_3697 ENOG4105BZU Histidine kinase ALFP_3698 ENOG4105DJ4 phosphatidylserine decarboxylase ALFP_3702 ENOG4105JAB phenazine biosynthesis protein, phzf family ALFP_3708 ENOG4105F5P DNA-damage-inducible protein d ALFP_3709 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) ALFP_3716 ENOG4105CP9 extracellular ligand-binding receptor ALFP_3717 ENOG4105C32 Amino acid ABC transporter (Permease) ALFP_3719 ENOG4105C0Z ABC transporter ALFP_3720 ENOG4108IV0 ABC, transporter ALFP_3723 ENOG4108UAU isochorismatase ALFP_3728 ENOG4105CH6 catalase ALFP_3729 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins ALFP_3730 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) ALFP_3731 ENOG4105X5M RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) ALFP_3732 ENOG4105VG0 50S ribosomal protein l34