locus-tag	class	description
MF263_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
MF263_00010	COG0592	DNA-directed DNA polymerase activity
MF263_00020	COG1187	pseudouridine synthase activity
MF263_00035	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
MF263_00060	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
MF263_00065	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
MF263_00080	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
MF263_00100	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
MF263_00120	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
MF263_00125	COG0583	DNA-binding transcription factor activity
MF263_00135	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
MF263_00140	COG1802	Transcriptional regulator
MF263_00145	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
MF263_00150	COG2271	Major facilitator Superfamily
MF263_00170	COG0559	Belongs to the binding-protein-dependent transport system permease family
MF263_00185	COG0318	PFAM AMP-dependent synthetase and ligase
MF263_00195	COG0596	Alpha beta hydrolase
MF263_00195	COG0508	dehydrogenase complex catalyzes the overall conversion of
MF263_00200	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MF263_00215	COG3181	Tripartite tricarboxylate transporter family receptor
MF263_00225	COG0697	spore germination
MF263_00230	COG0583	DNA-binding transcription factor activity
MF263_00240	COG3842	ATPase activity
MF263_00250	COG0436	Aminotransferase
MF263_00260	COG0523	cobalamin synthesis protein
MF263_00315	COG1846	Transcriptional regulator
MF263_00335	COG0179	Fumarylacetoacetate (FAA) hydrolase
MF263_00340	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
MF263_00345	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
MF263_00355	COG4638	Rieske (2fe-2S)
MF263_00410	COG1028	Short-chain dehydrogenase reductase Sdr
MF263_00420	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
MF263_00435	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
MF263_00460	COG1595	DNA-templated transcription, initiation
MF263_00465	COG4608	Belongs to the ABC transporter superfamily
MF263_00470	COG0444	Belongs to the ABC transporter superfamily
MF263_00475	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MF263_00480	COG0601	transmembrane transport
MF263_00490	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
MF263_00495	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
MF263_00515	COG1464	Belongs to the NlpA lipoprotein family
MF263_00520	COG1464	Belongs to the NlpA lipoprotein family
MF263_00525	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
MF263_00530	COG2011	ABC-type metal ion transport system permease component
MF263_00555	COG1464	Belongs to the NlpA lipoprotein family
MF263_00570	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MF263_00575	COG0431	NADPH-dependent FMN reductase
MF263_00610	COG4149	molybdate abc transporter
MF263_00625	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
MF263_00630	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
MF263_00640	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
MF263_00660	COG0028	Belongs to the TPP enzyme family
MF263_00665	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
MF263_00685	COG3391	amine dehydrogenase activity
MF263_00715	COG2922	Belongs to the Smg family
MF263_00735	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
MF263_00740	COG0183	Belongs to the thiolase family
MF263_00745	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
MF263_00750	COG1960	acyl-CoA dehydrogenase activity
MF263_00770	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
MF263_00780	COG0018	arginyl-trna synthetase
MF263_00805	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
MF263_00820	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
MF263_00825	COG4774	siderophore transport
MF263_00830	COG0066	3-isopropylmalate dehydratase activity
MF263_00835	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
MF263_00840	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
MF263_00845	COG1804	L-carnitine dehydratase bile acid-inducible protein F
MF263_00850	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
MF263_00850	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
MF263_00860	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
MF263_00865	COG1335	isochorismatase
MF263_00870	COG0583	DNA-binding transcription factor activity
MF263_00890	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
MF263_00895	COG1280	lysine exporter protein (LysE YggA)
MF263_00900	COG0513	Belongs to the DEAD box helicase family
MF263_00910	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
MF263_00925	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
MF263_00940	COG0154	amidase activity
MF263_00955	COG0583	DNA-binding transcription factor activity
MF263_00975	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
MF263_00975	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
MF263_00985	COG0270	DNA (cytosine-5-)-methyltransferase activity
MF263_00995	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
MF263_01000	COG1127	ABC transporter
MF263_01020	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
MF263_01025	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
MF263_01035	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
MF263_01065	COG0583	DNA-binding transcription factor activity
MF263_01085	COG3093	addiction module antidote protein HigA
MF263_01100	COG1254	Belongs to the acylphosphatase family
MF263_01110	COG2358	TRAP transporter, solute receptor (TAXI family
MF263_01120	COG0564	pseudouridine synthase activity
MF263_01125	COG0252	asparaginase activity
MF263_01150	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
MF263_01155	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
MF263_01160	COG3181	Tripartite tricarboxylate transporter family receptor
MF263_01180	COG0559	Belongs to the binding-protein-dependent transport system permease family
MF263_01205	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MF263_01220	COG0758	DNA mediated transformation
MF263_01225	COG0242	peptide deformylase activity
MF263_01230	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
MF263_01235	COG0697	spore germination
MF263_01250	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
MF263_01265	COG4336	lyase activity
MF263_01270	COG0583	DNA-binding transcription factor activity
MF263_01275	COG0859	PFAM glycosyl transferase family 9
MF263_01285	COG1278	Cold shock
MF263_01290	COG1210	Utp--glucose-1-phosphate uridylyltransferase
MF263_01295	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
MF263_01300	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
MF263_01300	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
MF263_01310	COG1686	Belongs to the peptidase S11 family
MF263_01320	COG2921	Belongs to the UPF0250 family
MF263_01325	COG0321	lipoyl(octanoyl) transferase activity
MF263_01330	COG1024	Enoyl-CoA hydratase
MF263_01335	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
MF263_01345	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
MF263_01390	COG0826	peptidase U32
MF263_01400	COG3154	lipid carrier protein
MF263_01425	COG0134	indole-3-glycerol-phosphate synthase activity
MF263_01430	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
MF263_01435	COG0512	Glutamine amidotransferase of anthranilate synthase
MF263_01445	COG0546	phosphoglycolate phosphatase activity
MF263_01455	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
MF263_01460	COG2967	ApaG domain
MF263_01465	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
MF263_01470	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
MF263_01475	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
MF263_01485	COG0840	transmembrane signaling receptor activity
MF263_01495	COG1028	Short-chain dehydrogenase reductase Sdr
MF263_01500	COG3433	isochorismatase activity
MF263_01500	COG1535	isochorismatase
MF263_01505	COG1169	isochorismate synthase
MF263_01520	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
MF263_01525	COG1535	isochorismatase
MF263_01525	COG3433	isochorismatase activity
MF263_01530	COG1021	2,3-dihydroxybenzoate-AMP ligase
MF263_01560	COG0683	leucine binding
MF263_01575	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
MF263_01590	COG1250	3-hydroxyacyl-CoA dehydrogenase
MF263_01610	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
MF263_01615	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MF263_01620	COG2819	hydrolase of the alpha beta superfamily
MF263_01625	COG0513	Belongs to the DEAD box helicase family
MF263_01630	COG2814	Major facilitator Superfamily
MF263_01640	COG0583	DNA-binding transcription factor activity
MF263_01650	COG1253	flavin adenine dinucleotide binding
MF263_01675	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
MF263_01685	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
MF263_01700	COG2311	Membrane
MF263_01710	COG1132	(ABC) transporter
MF263_01720	COG0456	acetyltransferase
MF263_01740	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
MF263_01755	COG0402	S-adenosylhomocysteine deaminase activity
MF263_01760	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
MF263_01765	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
MF263_01775	COG0583	DNA-binding transcription factor activity
MF263_01780	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MF263_01785	COG1126	abc transporter atp-binding protein
MF263_01790	COG0765	amino acid transport
MF263_01795	COG0765	amino acid transport
MF263_01800	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
MF263_01810	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
MF263_01825	COG3391	amine dehydrogenase activity
MF263_01835	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
MF263_01860	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
MF263_01865	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
MF263_01870	COG0210	DNA helicase
MF263_01885	COG0067	glutamate synthase
MF263_01885	COG0070	glutamate synthase
MF263_01885	COG0069	glutamate synthase activity
MF263_01890	COG1024	Enoyl-CoA hydratase
MF263_01900	COG1804	L-carnitine dehydratase bile acid-inducible protein F
MF263_01905	COG1250	3-hydroxyacyl-CoA dehydrogenase
MF263_01935	COG2918	glutathione biosynthetic process
MF263_01950	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
MF263_01960	COG2223	nitrite transmembrane transporter activity
MF263_01965	COG2860	membrane
MF263_01970	COG1346	cytolysis
MF263_01985	COG0251	oxidation-reduction process
MF263_02010	COG1280	lysine exporter protein (LysE YggA)
MF263_02020	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
MF263_02035	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
MF263_02050	COG2096	Adenosyltransferase
MF263_02065	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
MF263_02070	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
MF263_02080	COG0523	cobalamin synthesis protein
MF263_02085	COG0735	belongs to the Fur family
MF263_02100	COG1108	ABC-type Mn2 Zn2 transport systems permease components
MF263_02105	COG0803	Belongs to the bacterial solute-binding protein 9 family
MF263_02110	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
MF263_02120	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
MF263_02125	COG1560	Kdo2-lipid A biosynthetic process
MF263_02135	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
MF263_02140	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
MF263_02145	COG1950	PFAM Membrane protein of
MF263_02180	COG0275	rRNA processing
MF263_02185	COG0730	response to heat
MF263_02190	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
MF263_02195	COG0129	dihydroxy-acid dehydratase activity
MF263_02205	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
MF263_02215	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
MF263_02215	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
MF263_02220	COG0154	amidase activity
MF263_02230	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
MF263_02235	COG0628	permease
MF263_02265	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
MF263_02270	COG0656	L-ascorbic acid biosynthetic process
MF263_02275	COG2814	Major facilitator Superfamily
MF263_02280	COG0583	DNA-binding transcription factor activity
MF263_02290	COG3685	Protein conserved in bacteria
MF263_02315	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
MF263_02320	COG2814	Major facilitator Superfamily
MF263_02325	COG0655	NAD(P)H dehydrogenase (quinone) activity
MF263_02330	COG0583	DNA-binding transcription factor activity
MF263_02345	COG4774	siderophore transport
MF263_02350	COG4607	ABC-type enterochelin transport system periplasmic component
MF263_02355	COG4604	ABC transporter, ATP-binding protein
MF263_02360	COG4605	iron ion homeostasis
MF263_02365	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MF263_02375	COG2375	cellular response to nickel ion
MF263_02375	COG1132	(ABC) transporter
MF263_02380	COG0277	FAD linked oxidase domain protein
MF263_02385	COG1304	FMN binding
MF263_02390	COG2186	Transcriptional regulator
MF263_02410	COG1609	Transcriptional regulator
MF263_02415	COG1522	sequence-specific DNA binding
MF263_02420	COG3844	kynureninase activity
MF263_02425	COG1113	amino acid transport
MF263_02445	COG1349	DNA-binding transcription factor activity
MF263_02465	COG0395	ABC-type sugar transport system, permease component
MF263_02490	COG0861	Integral membrane protein TerC family
MF263_02495	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
MF263_02505	COG1671	Belongs to the UPF0178 family
MF263_02515	COG1418	mRNA catabolic process
MF263_02525	COG4948	Mandelate Racemase Muconate Lactonizing
MF263_02535	COG0477	Major facilitator Superfamily
MF263_02550	COG0154	amidase activity
MF263_02560	COG0583	DNA-binding transcription factor activity
MF263_02585	COG0326	Molecular chaperone. Has ATPase activity
MF263_02590	COG4774	siderophore transport
MF263_02595	COG3128	pkhd-type hydroxylase
MF263_02605	COG3023	N-Acetylmuramoyl-L-alanine amidase
MF263_02620	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
MF263_02625	COG1652	LysM domain
MF263_02640	COG0220	tRNA (guanine-N7-)-methyltransferase activity
MF263_02660	COG1535	isochorismatase
MF263_02660	COG3433	isochorismatase activity
MF263_02685	COG0583	DNA-binding transcription factor activity
MF263_02695	COG0387	Pfam Sodium calcium exchanger
MF263_02710	COG0477	Major facilitator Superfamily
MF263_02715	COG0235	Class ii aldolase
MF263_02730	COG3391	amine dehydrogenase activity
MF263_02735	COG0590	tRNA wobble adenosine to inosine editing
MF263_02740	COG3257	ureidoglycine aminohydrolase activity
MF263_02745	COG0583	DNA-binding transcription factor activity
MF263_02750	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
MF263_02755	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MF263_02755	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MF263_02765	COG0489	protein tyrosine kinase activity
MF263_02790	COG2081	HI0933 family
MF263_02795	COG0509	glycine decarboxylation via glycine cleavage system
MF263_02805	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
MF263_02810	COG1765	OsmC-like protein
MF263_02815	COG3278	Belongs to the heme-copper respiratory oxidase family
MF263_02840	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
MF263_02845	COG0469	pyruvate kinase activity
MF263_02850	COG3193	protein, possibly involved in utilization of glycolate and propanediol
MF263_02860	COG2084	Dehydrogenase
MF263_02865	COG3622	Belongs to the hyi family
MF263_02870	COG3960	tartronate-semialdehyde synthase activity
MF263_02875	COG0583	DNA-binding transcription factor activity
MF263_02885	COG2233	PERMEase
MF263_02890	COG1942	4-Oxalocrotonate Tautomerase
MF263_02895	COG0235	Class ii aldolase
MF263_02900	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
MF263_02905	COG3648	Uricase
MF263_02905	COG3195	allantoin biosynthetic process
MF263_02915	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
MF263_02920	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
MF263_02935	COG0438	transferase activity, transferring glycosyl groups
MF263_02940	COG0438	transferase activity, transferring glycosyl groups
MF263_02945	COG0438	transferase activity, transferring glycosyl groups
MF263_02955	COG0277	FAD linked oxidase domain protein
MF263_02965	COG0179	Fumarylacetoacetate (FAA) hydrolase
MF263_02970	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
MF263_02980	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
MF263_02990	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
MF263_03000	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
MF263_03015	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
MF263_03020	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
MF263_03025	COG0193	aminoacyl-tRNA hydrolase activity
MF263_03035	COG0012	GTP binding
MF263_03045	COG1024	Enoyl-CoA hydratase
MF263_03050	COG0367	asparagine synthase
MF263_03065	COG0488	(ABC) transporter
MF263_03080	COG0288	reversible hydration of carbon dioxide
MF263_03085	COG0583	DNA-binding transcription factor activity
MF263_03095	COG4133	protoheme IX ABC transporter activity
MF263_03105	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
MF263_03115	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
MF263_03125	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MF263_03130	COG3088	subunit of a heme lyase
MF263_03135	COG4235	cytochrome complex assembly
MF263_03140	COG0785	Cytochrome C biogenesis protein
MF263_03150	COG2169	Transcriptional regulator
MF263_03150	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
MF263_03170	COG0559	Belongs to the binding-protein-dependent transport system permease family
MF263_03180	COG0411	ABC transporter
MF263_03190	COG1858	cytochrome C peroxidase
MF263_03195	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
MF263_03200	COG1959	2 iron, 2 sulfur cluster binding
MF263_03205	COG2346	COG2346, Truncated hemoglobins
MF263_03210	COG0463	Glycosyl transferase, family 2
MF263_03250	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
MF263_03255	COG3383	formate dehydrogenase (NAD+) activity
MF263_03270	COG1910	domain protein
MF263_03275	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
MF263_03285	COG0303	'Molybdopterin
MF263_03290	COG0521	Mo-molybdopterin cofactor biosynthetic process
MF263_03295	COG0314	molybdopterin synthase activity
MF263_03305	COG0315	cyclic pyranopterin monophosphate synthase activity
MF263_03345	COG0678	peroxiredoxin activity
MF263_03360	COG0697	spore germination
MF263_03365	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
MF263_03400	COG2814	Major facilitator Superfamily
MF263_03440	COG0815	Transfers the fatty acyl group on membrane lipoproteins
MF263_03445	COG4535	Mg2 and Co2 transporter CorC
MF263_03450	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
MF263_03455	COG1702	phosphate starvation-inducible protein PhoH
MF263_03460	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
MF263_03470	COG0024	Methionine aminopeptidase
MF263_03475	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
MF263_03480	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
MF263_03485	COG1862	Preprotein translocase
MF263_03490	COG0343	queuine tRNA-ribosyltransferase activity
MF263_03495	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
MF263_03500	COG2027	D-alanyl-D-alanine carboxypeptidase
MF263_03505	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
MF263_03515	COG4575	ribosome binding
MF263_03530	COG0583	DNA-binding transcription factor activity
MF263_03545	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
MF263_03560	COG0154	amidase activity
MF263_03570	COG0477	Major facilitator Superfamily
MF263_03580	COG0346	lactoylglutathione lyase activity
MF263_03585	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
MF263_03595	COG0436	Aminotransferase
MF263_03605	COG0281	malic enzyme
MF263_03605	COG0280	phosphate acetyltransferase
MF263_03615	COG2732	(Barnase) inhibitor
MF263_03620	COG1385	rRNA (uridine-N3-)-methyltransferase activity
MF263_03625	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
MF263_03630	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
MF263_03635	COG0126	phosphoglycerate kinase activity
MF263_03660	COG0521	Mo-molybdopterin cofactor biosynthetic process
MF263_03670	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
MF263_03675	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
MF263_03680	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
MF263_03685	COG0009	L-threonylcarbamoyladenylate synthase
MF263_03690	COG0596	Alpha beta hydrolase
MF263_03695	COG2030	dehydratase
MF263_03695	COG1012	belongs to the aldehyde dehydrogenase family
MF263_03700	COG1960	acyl-CoA dehydrogenase activity
MF263_03710	COG0405	Gamma-glutamyltransferase
MF263_03720	COG0579	oxidoreductase
MF263_03725	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
MF263_03730	COG0259	pyridoxamine-phosphate oxidase activity
MF263_03740	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
MF263_03755	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
MF263_03760	COG1215	transferase activity, transferring glycosyl groups
MF263_03770	COG0488	(ABC) transporter
MF263_03790	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
MF263_03795	COG2894	cell division
MF263_03805	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
MF263_03810	COG1271	oxidase subunit
MF263_03815	COG1294	oxidase, subunit
MF263_03820	COG0038	chloride channel
MF263_03830	COG0514	ATP-dependent DNA helicase (RecQ)
MF263_03835	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
MF263_03840	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
MF263_03845	COG0633	Ferredoxin
MF263_03850	COG0488	(ABC) transporter
MF263_03860	COG2001	Belongs to the MraZ family
MF263_03865	COG0275	rRNA processing
MF263_03870	COG3116	cell division
MF263_03880	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
MF263_03885	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
MF263_03890	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
MF263_03900	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
MF263_03905	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
MF263_03910	COG1181	Belongs to the D-alanine--D-alanine ligase family
MF263_03915	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
MF263_03930	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
MF263_03940	COG0739	heme binding
MF263_03940	COG0741	lytic transglycosylase activity
MF263_03940	COG1196	nuclear chromosome segregation
MF263_03945	COG0653	protein targeting
MF263_03955	COG2239	Acts as a magnesium transporter
MF263_03965	COG1473	amidohydrolase
MF263_03970	COG0318	PFAM AMP-dependent synthetase and ligase
MF263_03980	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
MF263_03980	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
MF263_03995	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
MF263_04000	COG2011	ABC-type metal ion transport system permease component
MF263_04010	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MF263_04015	COG0765	amino acid transport
MF263_04020	COG1126	abc transporter atp-binding protein
MF263_04040	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
MF263_04045	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
MF263_04050	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
MF263_04055	COG0700	Nucleoside recognition
MF263_04070	COG0204	Acyl-transferase
MF263_04075	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
MF263_04080	COG0751	glycine-tRNA ligase activity
MF263_04085	COG0752	glycyl-tRNA synthetase alpha subunit
MF263_04105	COG1309	transcriptional regulator
MF263_04115	COG2814	Major facilitator Superfamily
MF263_04130	COG1573	uracil-dna glycosylase
MF263_04135	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
MF263_04140	COG0617	tRNA 3'-terminal CCA addition
MF263_04150	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
MF263_04155	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
MF263_04160	COG1953	Uracil, thiamine, allantoin
MF263_04165	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
MF263_04170	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
MF263_04175	COG0586	Pfam SNARE associated Golgi protein
MF263_04180	COG0860	N-Acetylmuramoyl-L-alanine amidase
MF263_04185	COG0802	atpase or kinase
MF263_04195	COG3181	Tripartite tricarboxylate transporter family receptor
MF263_04200	COG0280	phosphate acetyltransferase
MF263_04200	COG0281	malic enzyme
MF263_04205	COG0583	DNA-binding transcription factor activity
MF263_04210	COG1012	belongs to the aldehyde dehydrogenase family
MF263_04215	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
MF263_04235	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
MF263_04270	COG1733	regulation of RNA biosynthetic process
MF263_04275	COG2910	NAD(P)H-binding
MF263_04285	COG2223	nitrite transmembrane transporter activity
MF263_04290	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
MF263_04295	COG4974	Belongs to the 'phage' integrase family
MF263_04300	COG0725	ABC transporter, periplasmic molybdate-binding protein
MF263_04305	COG4149	molybdate abc transporter
MF263_04310	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
MF263_04325	COG1074	ATP-dependent DNA helicase activity
MF263_04360	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
MF263_04380	COG3391	amine dehydrogenase activity
MF263_04385	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
MF263_04390	COG0505	Belongs to the CarA family
MF263_04395	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
MF263_04415	COG2233	PERMEase
MF263_04420	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
MF263_04425	COG1534	Rna-binding protein
MF263_04430	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
MF263_04435	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MF263_04445	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
MF263_04455	COG0248	Ppx GppA phosphatase
MF263_04460	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
MF263_04480	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
MF263_04485	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
MF263_04535	COG1231	oxidoreductase activity
MF263_04540	COG2010	Cytochrome c
MF263_04545	COG2323	membrane
MF263_04560	COG1368	sulfuric ester hydrolase activity
MF263_04590	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
MF263_04595	COG3327	negative regulation of DNA-templated transcription, initiation
MF263_04600	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
MF263_04625	COG0009	L-threonylcarbamoyladenylate synthase
MF263_04630	COG1994	Peptidase M50
MF263_04635	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
MF263_04640	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
MF263_04655	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
MF263_04665	COG0156	8-amino-7-oxononanoate synthase activity
MF263_04670	COG2124	cytochrome p450
MF263_04675	COG3135	benzoate transporter
MF263_04685	COG2850	peptidyl-arginine hydroxylation
MF263_04695	COG3391	amine dehydrogenase activity
MF263_04705	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MF263_04710	COG0577	efflux transmembrane transporter activity
MF263_04710	COG1136	(ABC) transporter
MF263_04715	COG1538	Outer membrane efflux protein
MF263_04720	COG0363	glucosamine-6-phosphate deaminase activity
MF263_04725	COG1132	(ABC) transporter
MF263_04735	COG3181	Tripartite tricarboxylate transporter family receptor
MF263_04745	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MF263_04755	COG0668	transmembrane transport
MF263_04800	COG0154	amidase activity
MF263_04805	COG2031	fatty acid transporter
MF263_04820	COG0483	inositol monophosphate 1-phosphatase activity
MF263_04825	COG1253	flavin adenine dinucleotide binding
MF263_04830	COG1968	undecaprenyl-diphosphatase activity
MF263_04850	COG0215	cysteine-tRNA ligase activity
MF263_04860	COG0825	malonyl-CoA metabolic process
MF263_04865	COG0037	tRNA processing
MF263_04890	COG0330	HflC and HflK could
MF263_04905	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
MF263_04925	COG1178	ABC-type Fe3 transport system permease component
MF263_04930	COG3842	ATPase activity
MF263_04940	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
MF263_04970	COG4773	Receptor
MF263_04985	COG1304	FMN binding
MF263_04990	COG0435	Glutathione S-transferase
MF263_04995	COG0655	NAD(P)H dehydrogenase (quinone) activity
MF263_05010	COG2094	Belongs to the DNA glycosylase MPG family
MF263_05015	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
MF263_05020	COG2363	Small membrane protein
MF263_05025	COG0598	Magnesium transport protein CorA
MF263_05030	COG1960	acyl-CoA dehydrogenase activity
MF263_05040	COG0747	negative chemotaxis
MF263_05050	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MF263_05055	COG4172	Belongs to the ABC transporter superfamily
MF263_05065	COG3284	Transcriptional regulator
MF263_05070	COG1012	belongs to the aldehyde dehydrogenase family
MF263_05075	COG1454	alcohol dehydrogenase
MF263_05095	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
MF263_05105	COG0183	Belongs to the thiolase family
MF263_05110	COG0318	PFAM AMP-dependent synthetase and ligase
MF263_05120	COG1028	Short-chain dehydrogenase reductase Sdr
MF263_05125	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
MF263_05150	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
MF263_05180	COG3829	transcription factor binding
MF263_05200	COG0039	L-malate dehydrogenase activity
MF263_05205	COG2188	Transcriptional regulator
MF263_05210	COG2009	succinate dehydrogenase
MF263_05220	COG1053	succinate dehydrogenase
MF263_05225	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
MF263_05230	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
MF263_05235	COG0372	Belongs to the citrate synthase family
MF263_05240	COG2186	Transcriptional regulator
MF263_05245	COG1620	l-lactate permease
MF263_05250	COG0038	chloride channel
MF263_05260	COG0280	phosphate acetyltransferase
MF263_05260	COG0281	malic enzyme
MF263_05265	COG0567	Dehydrogenase, E1 component
MF263_05270	COG0508	dehydrogenase complex catalyzes the overall conversion of
MF263_05275	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MF263_05280	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
MF263_05300	COG2183	response to ionizing radiation
MF263_05305	COG1199	ATP-dependent helicase activity
MF263_05315	COG1733	regulation of RNA biosynthetic process
MF263_05330	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
MF263_05330	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
MF263_05335	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
MF263_05345	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
MF263_05345	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
MF263_05360	COG0564	pseudouridine synthase activity
MF263_05370	COG3243	poly(R)-hydroxyalkanoic acid synthase
MF263_05375	COG1028	Short-chain dehydrogenase reductase Sdr
MF263_05380	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
MF263_05420	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
MF263_05425	COG1187	pseudouridine synthase activity
MF263_05430	COG0779	Required for maturation of 30S ribosomal subunits
MF263_05435	COG0195	Participates in both transcription termination and antitermination
MF263_05435	COG2251	uridine kinase activity
MF263_05445	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
MF263_05450	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
MF263_05455	COG1217	gtp-binding protein TYPA
MF263_05460	COG0446	pyridine nucleotide-disulphide oxidoreductase
MF263_05470	COG4160	amino acid transport
MF263_05475	COG4215	(ABC) transporter
MF263_05495	COG1283	sodium-dependent phosphate transmembrane transporter activity
MF263_05505	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
MF263_05525	COG0501	Belongs to the peptidase M48B family
MF263_05535	COG3344	reverse transcriptase
MF263_05550	COG1722	exodeoxyribonuclease VII activity
MF263_05555	COG0142	geranyltranstransferase activity
MF263_05560	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
MF263_05565	COG1469	GTP cyclohydrolase I activity
MF263_05570	COG0360	Binds together with S18 to 16S ribosomal RNA
MF263_05575	COG2965	DNA replication, synthesis of RNA primer
MF263_05580	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
MF263_05590	COG0305	Participates in initiation and elongation during chromosome replication
MF263_05600	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
MF263_05605	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
MF263_05610	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
MF263_05620	COG0436	Aminotransferase
MF263_05635	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MF263_05640	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
MF263_05645	COG1562	ergosterol biosynthetic process
MF263_05650	COG1562	ergosterol biosynthetic process
MF263_05655	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
MF263_05660	COG1028	Short-chain dehydrogenase reductase Sdr
MF263_05685	COG3842	ATPase activity
MF263_05690	COG1176	ABC-type spermidine putrescine transport system, permease component I
MF263_05695	COG1177	transmembrane transport
MF263_05700	COG1393	Belongs to the ArsC family
MF263_05705	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
MF263_05710	COG0704	Plays a role in the regulation of phosphate uptake
MF263_05715	COG5001	Diguanylate cyclase
MF263_05715	COG4251	negative regulation of phosphorylation
MF263_05715	COG3706	GGDEF domain
MF263_05715	COG2203	Gaf domain
MF263_05720	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
MF263_05725	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
MF263_05725	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
MF263_05730	COG1643	Atp-dependent helicase
MF263_05740	COG0438	transferase activity, transferring glycosyl groups
MF263_05745	COG0726	polysaccharide deacetylase
MF263_05760	COG0438	transferase activity, transferring glycosyl groups
MF263_05785	COG1132	(ABC) transporter
MF263_05835	COG2186	Transcriptional regulator
MF263_05840	COG0277	FAD linked oxidase domain protein
MF263_05845	COG0277	FAD linked oxidase domain protein
MF263_05850	COG0247	lactate metabolic process
MF263_05875	COG1012	belongs to the aldehyde dehydrogenase family
MF263_05925	COG0628	permease
MF263_05930	COG1283	sodium-dependent phosphate transmembrane transporter activity
MF263_05945	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
MF263_05955	COG0697	spore germination
MF263_05975	COG3094	Invasion gene expression up-regulator, SirB
MF263_05985	COG0640	Transcriptional regulator
MF263_06010	COG0659	secondary active sulfate transmembrane transporter activity
MF263_06015	COG1262	PFAM Formylglycine-generating sulfatase enzyme
MF263_06025	COG2314	TM2 domain
MF263_06030	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
MF263_06035	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
MF263_06040	COG0791	NLP P60 protein
MF263_06060	COG1360	Flagellar Motor Protein
MF263_06070	COG0835	chemotaxis
MF263_06075	COG0840	transmembrane signaling receptor activity
MF263_06080	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
MF263_06090	COG0745	RESPONSE REGULATOR receiver
MF263_06095	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
MF263_06105	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
MF263_06130	COG1815	bacterial-type flagellum-dependent cell motility
MF263_06135	COG1558	bacterial-type flagellum-dependent cell motility
MF263_06140	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
MF263_06180	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
MF263_06205	COG2176	DNA-directed DNA polymerase activity
MF263_06215	COG1987	bacterial-type flagellum assembly
MF263_06230	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
MF263_06240	COG1580	Controls the rotational direction of flagella during chemotaxis
MF263_06255	COG1157	protein secretion by the type III secretion system
MF263_06270	COG1766	The M ring may be actively involved in energy transduction
MF263_06275	COG1677	Flagellar hook-basal body complex protein FliE
MF263_06280	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
MF263_06305	COG1334	flagellar protein FlaG
MF263_06310	COG1191	sigma factor activity
MF263_06370	COG1262	PFAM Formylglycine-generating sulfatase enzyme
MF263_06390	COG2733	membrane
MF263_06395	COG0840	transmembrane signaling receptor activity
MF263_06400	COG0840	transmembrane signaling receptor activity
MF263_06415	COG3181	Tripartite tricarboxylate transporter family receptor
MF263_06425	COG2080	2 iron, 2 sulfur cluster binding
MF263_06430	COG1529	Aldehyde oxidase and xanthine dehydrogenase
MF263_06430	COG2010	Cytochrome c
MF263_06435	COG2610	gluconate transmembrane transporter activity
MF263_06445	COG0582	viral genome integration into host DNA
MF263_06490	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
MF263_06495	COG3657	addiction module killer protein
MF263_06500	COG4521	taurine ABC transporter
MF263_06510	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
MF263_06515	COG1028	Short-chain dehydrogenase reductase Sdr
MF263_06530	COG2824	Alkylphosphonate utilization operon protein PhnA
MF263_06545	COG4771	TonB-dependent receptor
MF263_06550	COG1858	cytochrome C peroxidase
MF263_06560	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
MF263_06570	COG1113	amino acid transport
MF263_06575	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
MF263_06590	COG0583	DNA-binding transcription factor activity
MF263_06595	COG3755	Protein conserved in bacteria
MF263_06600	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
MF263_06640	COG0446	pyridine nucleotide-disulphide oxidoreductase
MF263_06665	COG1278	Cold shock
MF263_06670	COG0642	Histidine kinase
MF263_06680	COG3278	Belongs to the heme-copper respiratory oxidase family
MF263_06695	COG3258	Cytochrome c
MF263_06700	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
MF263_06705	COG4774	siderophore transport
MF263_06740	COG0025	NhaP-type Na H and K H
MF263_06755	COG1289	transmembrane transporter activity
MF263_06760	COG2252	PERMEase
MF263_06780	COG1999	signal sequence binding
MF263_06795	COG0069	glutamate synthase activity
MF263_06805	COG1846	Transcriptional regulator
MF263_06810	COG1058	Belongs to the CinA family
MF263_06810	COG1546	Belongs to the CinA family
MF263_06815	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
MF263_06855	COG1028	Short-chain dehydrogenase reductase Sdr
MF263_06865	COG3264	Mechanosensitive ion channel
MF263_06865	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
MF263_06870	COG1196	nuclear chromosome segregation
MF263_06870	COG3264	Mechanosensitive ion channel
MF263_06875	COG0477	Major facilitator Superfamily
MF263_06890	COG1396	sequence-specific DNA binding
MF263_06895	COG3437	response regulator, receiver
MF263_06900	COG0784	Response regulator, receiver
MF263_06900	COG2198	Histidine kinase
MF263_06900	COG2205	protein histidine kinase activity
MF263_06905	COG2239	Acts as a magnesium transporter
MF263_06915	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
MF263_06920	COG1490	D-aminoacyl-tRNA deacylase activity
MF263_06935	COG0456	acetyltransferase
MF263_06945	COG0501	Belongs to the peptidase M48B family
MF263_07260	COG3179	chitinase
MF263_07285	COG2135	peptidase activity
MF263_07430	COG3772	lysozyme
MF263_07485	COG2199	diguanylate cyclase activity
MF263_07500	COG1522	sequence-specific DNA binding
MF263_07505	COG0626	cystathionine gamma-synthase activity
MF263_07515	COG0494	nUDIX hydrolase
MF263_07520	COG2832	Protein of unknown function (DUF454)
MF263_07530	COG0137	argininosuccinate synthase activity
MF263_07535	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
MF263_07540	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
MF263_07560	COG1609	Transcriptional regulator
MF263_07565	COG0518	GMP synthase (glutamine-hydrolyzing) activity
MF263_07565	COG0519	Catalyzes the synthesis of GMP from XMP
MF263_07575	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
MF263_07585	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
MF263_07590	COG2205	protein histidine kinase activity
MF263_07595	COG0745	RESPONSE REGULATOR receiver
MF263_07600	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
MF263_07610	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
MF263_07615	COG0268	Binds directly to 16S ribosomal RNA
MF263_07620	COG0728	peptidoglycan biosynthetic process
MF263_07630	COG0563	adenylate kinase activity
MF263_07635	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
MF263_07640	COG2835	tetraacyldisaccharide 4'-kinase activity
MF263_07645	COG1663	tetraacyldisaccharide 4'-kinase activity
MF263_07650	COG0848	biopolymer transport protein
MF263_07655	COG0811	peptide transport
MF263_07660	COG1570	exodeoxyribonuclease VII activity
MF263_07665	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
MF263_07680	COG0183	Belongs to the thiolase family
MF263_07690	COG1278	Cold shock
MF263_07695	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
MF263_07700	COG0542	response to heat
MF263_07705	COG2995	paraquat-inducible protein a
MF263_07710	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
MF263_07710	COG3008	intermembrane lipid transfer
MF263_07730	COG0559	Belongs to the binding-protein-dependent transport system permease family
MF263_07765	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
MF263_07770	COG0756	dUTP diphosphatase activity
MF263_07780	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
MF263_07785	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
MF263_07790	COG0196	riboflavin kinase activity
MF263_07795	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
MF263_07800	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
MF263_07800	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
MF263_07810	COG0210	DNA helicase
MF263_07865	COG0488	(ABC) transporter
MF263_07870	COG2890	protein-(glutamine-N5) methyltransferase activity
MF263_07875	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
MF263_07880	COG2171	N-acyltransferase activity
MF263_07890	COG2207	Transcriptional regulator
MF263_07900	COG3273	potassium ion transport
MF263_07900	COG0471	metal ion transport
MF263_07940	COG0789	Transcriptional regulator
MF263_07955	COG1804	L-carnitine dehydratase bile acid-inducible protein F
MF263_07960	COG0544	peptidyl-prolyl cis-trans isomerase activity
MF263_07965	COG0740	serine-type endopeptidase activity
MF263_07975	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
MF263_07995	COG0556	nucleotide-excision repair
MF263_08000	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
MF263_08010	COG1104	cysteine desulfurase activity
MF263_08020	COG0316	Belongs to the HesB IscA family
MF263_08030	COG3181	Tripartite tricarboxylate transporter family receptor
MF263_08035	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
MF263_08040	COG4221	oxidoreductase activity
MF263_08050	COG0840	transmembrane signaling receptor activity
MF263_08055	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
MF263_08060	COG0697	spore germination
MF263_08065	COG0385	Bile acid
MF263_08075	COG2831	hemolysin activation secretion protein
MF263_08080	COG3210	domain, Protein
MF263_08105	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
MF263_08120	COG1136	(ABC) transporter
MF263_08125	COG0084	hydrolase, TatD family'
MF263_08140	COG0613	PHP domain protein
MF263_08150	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
MF263_08150	COG0047	phosphoribosylformylglycinamidine synthase activity
MF263_08180	COG0519	Catalyzes the synthesis of GMP from XMP
MF263_08180	COG0518	GMP synthase (glutamine-hydrolyzing) activity
MF263_08215	COG0583	DNA-binding transcription factor activity
MF263_08230	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
MF263_08240	COG1960	acyl-CoA dehydrogenase activity
MF263_08250	COG2378	regulation of single-species biofilm formation
MF263_08255	COG0523	cobalamin synthesis protein
MF263_08260	COG1469	GTP cyclohydrolase I activity
MF263_08265	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
MF263_08275	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
MF263_08280	COG0735	belongs to the Fur family
MF263_08285	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
MF263_08315	COG0745	RESPONSE REGULATOR receiver
MF263_08320	COG2207	Transcriptional regulator
MF263_08340	COG0583	DNA-binding transcription factor activity
MF263_08345	COG1289	transmembrane transporter activity
MF263_08355	COG1566	PFAM secretion protein HlyD family protein
MF263_08365	COG1942	4-Oxalocrotonate Tautomerase
MF263_08380	COG3162	membrane
MF263_08385	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
MF263_08395	COG2070	2-Nitropropane dioxygenase
MF263_08445	COG0625	glutathione transferase activity
MF263_08450	COG0583	DNA-binding transcription factor activity
MF263_08470	COG2816	NAD+ diphosphatase activity
MF263_08475	COG0625	glutathione transferase activity
MF263_08480	COG0740	serine-type endopeptidase activity
MF263_08530	COG1804	L-carnitine dehydratase bile acid-inducible protein F
MF263_08540	COG1960	acyl-CoA dehydrogenase activity
MF263_08570	COG0640	Transcriptional regulator
MF263_08595	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
MF263_08620	COG3485	protocatechuate 3,4-dioxygenase
MF263_08630	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
MF263_08635	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
MF263_08645	COG3135	benzoate transporter
MF263_08650	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
MF263_08655	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
MF263_08665	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
MF263_08675	COG2197	response regulator
MF263_08680	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
MF263_08705	COG1846	Transcriptional regulator
MF263_08710	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
MF263_08715	COG2271	Major facilitator Superfamily
MF263_08725	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
MF263_08735	COG0697	spore germination
MF263_08760	COG3842	ATPase activity
MF263_08790	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
MF263_08795	COG0667	Aldo Keto reductase
MF263_08815	COG0582	viral genome integration into host DNA
MF263_08830	COG0270	DNA (cytosine-5-)-methyltransferase activity
MF263_08900	COG3620	sequence-specific DNA binding
MF263_09150	COG1272	protein, Hemolysin III
MF263_09155	COG3422	double-strand break repair
MF263_09180	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MF263_09185	COG0765	amino acid transport
MF263_09190	COG0765	amino acid transport
MF263_09195	COG1126	abc transporter atp-binding protein
MF263_09235	COG2871	sodium ion transport
MF263_09265	COG2814	Major facilitator Superfamily
MF263_09270	COG1280	lysine exporter protein (LysE YggA)
MF263_09275	COG1609	Transcriptional regulator
MF263_09285	COG0402	S-adenosylhomocysteine deaminase activity
MF263_09310	COG0330	HflC and HflK could
MF263_09315	COG1585	Membrane protein implicated in regulation of membrane protease activity
MF263_09320	COG2226	methyltransferase
MF263_09330	COG3042	response to heat
MF263_09355	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
MF263_09360	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
MF263_09375	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
MF263_09380	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
MF263_09410	COG0291	Belongs to the bacterial ribosomal protein bL35 family
MF263_09415	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
MF263_09420	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
MF263_09425	COG0072	phenylalanine-tRNA ligase activity
MF263_09425	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MF263_09440	COG2833	Protein of unknown function (DUF455)
MF263_09455	COG5265	(ABC) transporter
MF263_09460	COG1959	2 iron, 2 sulfur cluster binding
MF263_09465	COG0719	Fe-S assembly protein
MF263_09470	COG0396	ATPase activity
MF263_09475	COG0719	Fe-S assembly protein
MF263_09485	COG0822	iron-sulfur transferase activity
MF263_09490	COG2151	metal-sulfur cluster biosynthetic enzyme
MF263_09510	COG1538	Outer membrane efflux protein
MF263_09525	COG2274	protein secretion by the type I secretion system
MF263_09535	COG1181	Belongs to the D-alanine--D-alanine ligase family
MF263_09535	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
MF263_09565	COG0747	negative chemotaxis
MF263_09570	COG0601	transmembrane transport
MF263_09575	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MF263_09580	COG4172	Belongs to the ABC transporter superfamily
MF263_09590	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
MF263_09645	COG0604	alcohol dehydrogenase
MF263_09650	COG2207	Transcriptional regulator
MF263_09655	COG3048	D-serine ammonia-lyase activity
MF263_09660	COG3258	Cytochrome c
MF263_09675	COG3949	Membrane
MF263_09685	COG1262	PFAM Formylglycine-generating sulfatase enzyme
MF263_09700	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
MF263_09705	COG0569	domain protein
MF263_09710	COG1902	pentaerythritol trinitrate reductase activity
MF263_09720	COG1610	YqeY-like protein
MF263_09725	COG0587	DNA-directed DNA polymerase activity
MF263_09765	COG0583	DNA-binding transcription factor activity
MF263_09770	COG1686	Belongs to the peptidase S11 family
MF263_09785	COG1360	Flagellar Motor Protein
MF263_09795	COG1028	Short-chain dehydrogenase reductase Sdr
MF263_09800	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MF263_09805	COG4221	oxidoreductase activity
MF263_09810	COG0307	riboflavin synthase, alpha
MF263_09825	COG1301	dicarboxylic acid transport
MF263_09830	COG4191	Histidine kinase
MF263_09840	COG0583	DNA-binding transcription factor activity
MF263_09845	COG1053	succinate dehydrogenase
MF263_09895	COG2233	PERMEase
MF263_09900	COG0071	Belongs to the small heat shock protein (HSP20) family
MF263_09905	COG1473	amidohydrolase
MF263_09915	COG2814	Major facilitator Superfamily
MF263_09945	COG2816	NAD+ diphosphatase activity
MF263_09950	COG1561	YicC-like family, N-terminal region
MF263_09965	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
MF263_09970	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
MF263_09975	COG0635	Involved in the biosynthesis of porphyrin-containing compound
MF263_09980	COG0174	glutamine synthetase
MF263_09985	COG2153	protein acetylation
MF263_10005	COG3842	ATPase activity
MF263_10010	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
MF263_10015	COG1840	ABC-type Fe3 transport system, periplasmic component
MF263_10030	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
MF263_10040	COG0783	Belongs to the Dps family
MF263_10050	COG3842	ATPase activity
MF263_10055	COG0395	ABC-type sugar transport system, permease component
MF263_10060	COG1175	transmembrane transport
MF263_10065	COG1653	transport
MF263_10080	COG0559	Belongs to the binding-protein-dependent transport system permease family
MF263_10100	COG0625	glutathione transferase activity
MF263_10110	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
MF263_10115	COG1028	Short-chain dehydrogenase reductase Sdr
MF263_10125	COG0114	fumarate hydratase activity
MF263_10130	COG2133	pyrroloquinoline quinone binding
MF263_10135	COG2226	methyltransferase
MF263_10140	COG0589	response to stress
MF263_10145	COG4654	Cytochrome c, class I
MF263_10150	COG2207	Transcriptional regulator
MF263_10155	COG0235	Class ii aldolase
MF263_10165	COG1012	belongs to the aldehyde dehydrogenase family
MF263_10170	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
MF263_10175	COG2807	transmembrane transport
MF263_10185	COG0583	DNA-binding transcription factor activity
MF263_10220	COG0583	DNA-binding transcription factor activity
MF263_10225	COG4974	Belongs to the 'phage' integrase family
MF263_10235	COG2132	Multicopper oxidase
MF263_10240	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
MF263_10255	COG1028	Short-chain dehydrogenase reductase Sdr
MF263_10300	COG3038	cytochrome b561
MF263_10310	COG2353	YceI-like domain
MF263_10315	COG1393	Belongs to the ArsC family
MF263_10320	COG0625	glutathione transferase activity
MF263_10345	COG0084	hydrolase, TatD family'
MF263_10350	COG0470	DNA polymerase III
MF263_10360	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
MF263_10365	COG0354	folic acid binding
MF263_10380	COG1960	acyl-CoA dehydrogenase activity
MF263_10385	COG2914	Belongs to the UPF0125 (RnfH) family
MF263_10390	COG2867	negative regulation of translational initiation
MF263_10395	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
MF263_10400	COG1252	NADH dehydrogenase
MF263_10425	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
MF263_10430	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
MF263_10435	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
MF263_10445	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
MF263_10450	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
MF263_10460	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
MF263_10470	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
MF263_10475	COG0575	Belongs to the CDS family
MF263_10480	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
MF263_10485	COG0233	cytoplasmic translational termination
MF263_10490	COG0528	UMP kinase activity
MF263_10495	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
MF263_10500	COG0052	Belongs to the universal ribosomal protein uS2 family
MF263_10505	COG0024	Methionine aminopeptidase
MF263_10510	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
MF263_10535	COG1286	toxin biosynthetic process
MF263_10545	COG0285	dihydrofolate synthase activity
MF263_10550	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MF263_10555	COG0508	dehydrogenase complex catalyzes the overall conversion of
MF263_10560	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
MF263_10575	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
MF263_10585	COG1999	signal sequence binding
MF263_10595	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
MF263_10600	COG0640	Transcriptional regulator
MF263_10615	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
MF263_10620	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
MF263_10625	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
MF263_10630	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
MF263_10635	COG1028	Short-chain dehydrogenase reductase Sdr
MF263_10640	COG1028	Short-chain dehydrogenase reductase Sdr
MF263_10660	COG0183	Belongs to the thiolase family
MF263_10680	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
MF263_10690	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
MF263_10695	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MF263_10700	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
MF263_10720	COG0183	Belongs to the thiolase family
MF263_10725	COG0183	Belongs to the thiolase family
MF263_10735	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
MF263_10770	COG0194	GDP metabolic process
MF263_10775	COG1758	RNA polymerase activity
MF263_10780	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
MF263_10785	COG0583	DNA-binding transcription factor activity
MF263_10790	COG0583	DNA-binding transcription factor activity
MF263_10795	COG0179	Fumarylacetoacetate (FAA) hydrolase
MF263_10815	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
MF263_10820	COG0739	heme binding
MF263_10825	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
MF263_10830	COG0584	glycerophosphoryl diester phosphodiesterase
MF263_10835	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
MF263_10840	COG1187	pseudouridine synthase activity
MF263_10845	COG3161	chorismate lyase activity
MF263_10850	COG2814	Major facilitator Superfamily
MF263_10855	COG0656	L-ascorbic acid biosynthetic process
MF263_10865	COG0668	transmembrane transport
MF263_10870	COG0165	Argininosuccinate lyase
MF263_10875	COG0789	Transcriptional regulator
MF263_10880	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
MF263_10895	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
MF263_10905	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
MF263_10915	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
MF263_10920	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
MF263_10925	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
MF263_10930	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
MF263_10935	COG2252	PERMEase
MF263_10940	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MF263_10960	COG0488	(ABC) transporter
MF263_10965	COG1619	proteins homologs of microcin C7 resistance protein MccF
MF263_10975	COG1131	(ABC) transporter
MF263_10980	COG0842	Transport permease protein
MF263_10990	COG1666	GTP binding
MF263_10995	COG0318	PFAM AMP-dependent synthetase and ligase
MF263_11000	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
MF263_11005	COG0519	Catalyzes the synthesis of GMP from XMP
MF263_11005	COG0518	GMP synthase (glutamine-hydrolyzing) activity
MF263_11010	COG2207	Transcriptional regulator
MF263_11025	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MF263_11030	COG0135	phosphoribosylanthranilate isomerase activity
MF263_11035	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
MF263_11045	COG0101	tRNA pseudouridine synthase activity
MF263_11055	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
MF263_11060	COG0473	3-isopropylmalate dehydrogenase activity
MF263_11080	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
MF263_11085	COG0625	glutathione transferase activity
MF263_11090	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
MF263_11105	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
MF263_11110	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
MF263_11120	COG1295	ribonuclease BN
MF263_11130	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
MF263_11135	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
MF263_11160	COG4964	Belongs to the GSP D family
MF263_11200	COG1595	DNA-templated transcription, initiation
MF263_11210	COG4774	siderophore transport
MF263_11215	COG3712	iron ion homeostasis
MF263_11240	COG2959	enzyme of heme biosynthesis
MF263_11250	COG0181	hydroxymethylbilane synthase activity
MF263_11255	COG0861	Integral membrane protein TerC family
MF263_11260	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
MF263_11265	COG0045	succinate-CoA ligase (ADP-forming) activity
MF263_11275	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
MF263_11280	COG0583	DNA-binding transcription factor activity
MF263_11285	COG2137	regulation of response to DNA damage stimulus
MF263_11290	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
MF263_11305	COG0477	Major facilitator Superfamily
MF263_11320	COG0318	PFAM AMP-dependent synthetase and ligase
MF263_11325	COG1024	Enoyl-CoA hydratase
MF263_11330	COG3162	membrane
MF263_11345	COG0540	Belongs to the ATCase OTCase family
MF263_11360	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
MF263_11375	COG2070	2-Nitropropane dioxygenase
MF263_11385	COG2111	Na H antiporter
MF263_11385	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
MF263_11390	COG1006	Multisubunit Na H antiporter MnhC subunit
MF263_11395	COG0651	ATP synthesis coupled electron transport
MF263_11405	COG2212	antiporter activity
MF263_11420	COG3158	transport of potassium into the cell
MF263_11425	COG0642	Histidine kinase
MF263_11450	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
MF263_11455	COG4208	sulfate ABC transporter
MF263_11460	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
MF263_11465	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
MF263_11470	COG4106	trans-aconitate 2-methyltransferase activity
MF263_11485	COG1278	Cold shock
MF263_11500	COG2135	peptidase activity
MF263_11530	COG0582	viral genome integration into host DNA
MF263_11550	COG3299	homolog of phage Mu protein gp47
MF263_11590	COG4386	tail sheath protein
MF263_11630	COG0616	signal peptide processing
MF263_11645	COG4626	Terminase
MF263_11645	COG1802	Transcriptional regulator
MF263_11670	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
MF263_11830	COG1522	sequence-specific DNA binding
MF263_11845	COG0535	radical SAM domain protein
MF263_11850	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
MF263_11850	COG1648	precorrin-2 dehydrogenase activity
MF263_11860	COG2010	Cytochrome c
MF263_11865	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MF263_11870	COG0626	cystathionine gamma-synthase activity
MF263_11875	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
MF263_11880	COG0557	exoribonuclease II activity
MF263_11915	COG0765	amino acid transport
MF263_11920	COG0765	amino acid transport
MF263_11925	COG1126	abc transporter atp-binding protein
MF263_11940	COG1850	ribulose-bisphosphate carboxylase activity
MF263_11960	COG2375	cellular response to nickel ion
MF263_11995	COG0583	DNA-binding transcription factor activity
MF263_12000	COG3842	ATPase activity
MF263_12010	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
MF263_12015	COG1840	ABC-type Fe3 transport system, periplasmic component
MF263_12035	COG0412	Dienelactone hydrolase
MF263_12040	COG3530	Putative quorum-sensing-regulated virulence factor
MF263_12045	COG0625	glutathione transferase activity
MF263_12055	COG1741	Belongs to the pirin family
MF263_12065	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
MF263_12070	COG2814	Major facilitator Superfamily
MF263_12075	COG2807	transmembrane transport
MF263_12080	COG2207	Transcriptional regulator
MF263_12085	COG3135	benzoate transporter
MF263_12110	COG1529	Aldehyde oxidase and xanthine dehydrogenase
MF263_12120	COG0402	S-adenosylhomocysteine deaminase activity
MF263_12135	COG2205	protein histidine kinase activity
MF263_12150	COG0828	Belongs to the bacterial ribosomal protein bS21 family
MF263_12155	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
MF263_12160	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
MF263_12170	COG0330	HflC and HflK could
MF263_12175	COG0330	HflC and HflK could
MF263_12180	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
MF263_12185	COG1923	regulation of RNA biosynthetic process
MF263_12195	COG1160	GTP binding
MF263_12200	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
MF263_12205	COG2976	Protein conserved in bacteria
MF263_12210	COG0124	histidyl-tRNA synthetase
MF263_12225	COG0820	rRNA (adenine-C2-)-methyltransferase activity
MF263_12230	COG0105	UTP biosynthetic process
MF263_12240	COG0583	DNA-binding transcription factor activity
MF263_12245	COG0697	spore germination
MF263_12250	COG0336	Belongs to the RNA methyltransferase TrmD family
MF263_12260	COG0228	four-way junction DNA binding
MF263_12265	COG0425	Belongs to the sulfur carrier protein TusA family
MF263_12270	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
MF263_12285	COG2351	hydroxyisourate hydrolase activity
MF263_12320	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
MF263_12345	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
MF263_12350	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
MF263_12375	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MF263_12380	COG0601	transmembrane transport
MF263_12410	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
MF263_12415	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
MF263_12420	COG0542	response to heat
MF263_12425	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
MF263_12440	COG0348	domain, Protein
MF263_12460	COG3278	Belongs to the heme-copper respiratory oxidase family
MF263_12470	COG2217	Heavy metal translocating P-type atpase
MF263_12475	COG2224	Isocitrate lyase
MF263_12480	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
MF263_12480	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
MF263_12500	COG1472	Belongs to the glycosyl hydrolase 3 family
MF263_12505	COG0736	holo-[acyl-carrier-protein] synthase activity
MF263_12515	COG2050	protein possibly involved in aromatic compounds catabolism
MF263_12520	COG1024	Enoyl-CoA hydratase
MF263_12525	COG1012	belongs to the aldehyde dehydrogenase family
MF263_12530	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
MF263_12535	COG2151	metal-sulfur cluster biosynthetic enzyme
MF263_12540	COG3396	Phenylacetate-CoA oxygenase
MF263_12545	COG3460	Phenylacetate-CoA oxygenase
MF263_12550	COG3396	Phenylacetate-CoA oxygenase
MF263_12555	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
MF263_12560	COG0501	Belongs to the peptidase M48B family
MF263_12565	COG1162	GTPase activity
MF263_12575	COG0335	large ribosomal subunit rRNA binding
MF263_12595	COG0450	alkyl hydroperoxide reductase
MF263_12600	COG1960	acyl-CoA dehydrogenase activity
MF263_12615	COG0123	including yeast histone deacetylase and acetoin utilization protein
MF263_12620	COG2951	lytic endotransglycosylase activity
MF263_12635	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
MF263_12640	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
MF263_12645	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
MF263_12665	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
MF263_12670	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
MF263_12675	COG0287	Prephenate dehydrogenase
MF263_12690	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
MF263_12705	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
MF263_12715	COG0583	DNA-binding transcription factor activity
MF263_12725	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
MF263_12745	COG0753	catalase activity
MF263_12750	COG1408	metallophosphoesterase
MF263_12755	COG4335	DNA alkylation repair
MF263_12765	COG0436	Aminotransferase
MF263_12775	COG0251	oxidation-reduction process
MF263_12780	COG1309	transcriptional regulator
MF263_12790	COG0488	(ABC) transporter
MF263_12840	COG0625	glutathione transferase activity
MF263_12850	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
MF263_12855	COG1280	lysine exporter protein (LysE YggA)
MF263_12875	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
MF263_12885	COG0784	Response regulator, receiver
MF263_12885	COG2198	Histidine kinase
MF263_12885	COG2205	protein histidine kinase activity
MF263_12890	COG2046	Belongs to the sulfate adenylyltransferase family
MF263_12895	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
MF263_12910	COG0840	transmembrane signaling receptor activity
MF263_12915	COG2119	membrane
MF263_12930	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
MF263_12935	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
MF263_12950	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
MF263_12955	COG2321	neutral zinc metallopeptidase
MF263_12970	COG2271	Major facilitator Superfamily
MF263_12975	COG2175	clavaminate synthase activity
MF263_12980	COG1846	Transcriptional regulator
MF263_12990	COG0347	Belongs to the P(II) protein family
MF263_12995	COG0004	ammonium transporteR
MF263_13000	COG3909	cytochrome
MF263_13010	COG0625	glutathione transferase activity
MF263_13020	COG0657	acetylesterase activity
MF263_13025	COG0730	response to heat
MF263_13030	COG0482	sulfurtransferase activity
MF263_13035	COG0277	FAD linked oxidase domain protein
MF263_13040	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
MF263_13045	COG2879	small protein
MF263_13050	COG1966	Carbon starvation protein
MF263_13055	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MF263_13060	COG0765	amino acid transport
MF263_13065	COG0765	amino acid transport
MF263_13070	COG1126	abc transporter atp-binding protein
MF263_13085	COG5285	phytanoyl-CoA dioxygenase
MF263_13090	COG0662	Cupin 2, conserved barrel domain protein
MF263_13100	COG0456	acetyltransferase
MF263_13105	COG1846	Transcriptional regulator
MF263_13115	COG0312	modulator of DNA gyrase
MF263_13130	COG0308	aminopeptidase N
MF263_13135	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
MF263_13150	COG0473	3-isopropylmalate dehydrogenase activity
MF263_13155	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
MF263_13160	COG0433	COG0433 Predicted ATPase
MF263_13165	COG0217	transcriptional regulatory protein
MF263_13170	COG0151	Belongs to the GarS family
MF263_13180	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
MF263_13185	COG0799	negative regulation of ribosome biogenesis
MF263_13190	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
MF263_13195	COG0424	maF-like protein
MF263_13215	COG0023	Translation Initiation Factor
MF263_13225	COG2084	Dehydrogenase
MF263_13230	COG0625	glutathione transferase activity
MF263_13235	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
MF263_13240	COG1047	Peptidyl-prolyl cis-trans
MF263_13245	COG2003	Belongs to the UPF0758 family
MF263_13250	COG1737	Transcriptional regulator
MF263_13255	COG0477	Major facilitator Superfamily
MF263_13265	COG2271	Major facilitator Superfamily
MF263_13280	COG0534	Mate efflux family protein
MF263_13285	COG4175	Glycine betaine
MF263_13290	COG4176	ABC-type proline glycine betaine transport system permease component
MF263_13300	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
MF263_13305	COG2814	Major facilitator Superfamily
MF263_13310	COG0227	Belongs to the bacterial ribosomal protein bL28 family
MF263_13315	COG0267	Belongs to the bacterial ribosomal protein bL33 family
MF263_13320	COG0495	leucyl-tRNA aminoacylation
MF263_13330	COG1466	dna polymerase III delta subunit
MF263_13335	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
MF263_13340	COG1981	membrane
MF263_13355	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
MF263_13365	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
MF263_13370	COG0148	phosphopyruvate hydratase activity
MF263_13380	COG2814	Major facilitator Superfamily
MF263_13395	COG2877	3-deoxy-8-phosphooctulonate synthase activity
MF263_13405	COG0504	CTP synthase activity
MF263_13440	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
MF263_13450	COG0791	NLP P60 protein
MF263_13460	COG0583	DNA-binding transcription factor activity
MF263_13470	COG0583	DNA-binding transcription factor activity
MF263_13480	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
MF263_13495	COG1045	serine acetyltransferase
MF263_13510	COG1381	Involved in DNA repair and RecF pathway recombination
MF263_13515	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
MF263_13520	COG0571	ribonuclease III activity
MF263_13535	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MF263_13560	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
MF263_13565	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
MF263_13570	COG1028	Short-chain dehydrogenase reductase Sdr
MF263_13575	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
MF263_13580	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
MF263_13590	COG0333	Belongs to the bacterial ribosomal protein bL32 family
MF263_13595	COG1399	metal-binding, possibly nucleic acid-binding protein
MF263_13605	COG0424	maF-like protein
MF263_13615	COG3023	N-Acetylmuramoyl-L-alanine amidase
MF263_13620	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
MF263_13625	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
MF263_13630	COG0546	phosphoglycolate phosphatase activity
MF263_13635	COG0564	pseudouridine synthase activity
MF263_13640	COG1530	ribonuclease E activity
MF263_13645	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
MF263_13650	COG0159	tryptophan synthase activity
MF263_13655	COG0133	tryptophan synthase activity
MF263_13660	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
MF263_13670	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
MF263_13675	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
MF263_13685	COG2878	Part of a membrane complex involved in electron transport
MF263_13690	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
MF263_13695	COG1129	ABC transporter
MF263_13700	COG3047	cAMP biosynthetic process
MF263_13725	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
MF263_13730	COG2917	probably involved in intracellular septation
MF263_13740	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
MF263_13745	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
MF263_13755	COG1196	nuclear chromosome segregation
MF263_13765	COG1573	uracil-dna glycosylase
MF263_13770	COG1214	PFAM Peptidase M22, glycoprotease
MF263_13785	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
MF263_13790	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
MF263_13795	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
MF263_13800	COG0560	Phosphoserine phosphatase
MF263_13815	COG1007	ATP synthesis coupled electron transport
MF263_13830	COG0713	ATP synthesis coupled electron transport
MF263_13840	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MF263_13845	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
MF263_13850	COG1034	ATP synthesis coupled electron transport
MF263_13865	COG0649	NAD binding
MF263_13870	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MF263_13875	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MF263_13880	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MF263_13885	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
MF263_13900	COG0149	triose-phosphate isomerase activity
MF263_13905	COG0604	alcohol dehydrogenase
MF263_13925	COG1185	polyribonucleotide nucleotidyltransferase activity
MF263_13930	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
MF263_13935	COG1183	phosphatidylcholine synthase activity
MF263_13940	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
MF263_13945	COG0440	acetolactate synthase activity
MF263_13950	COG0028	Belongs to the TPP enzyme family
MF263_13955	COG1289	transmembrane transporter activity
MF263_13960	COG3022	response to hydroperoxide
MF263_13965	COG1028	Short-chain dehydrogenase reductase Sdr
MF263_13985	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
MF263_13990	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
MF263_13995	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
MF263_14000	COG1674	ftsk spoiiie
MF263_14005	COG0492	ferredoxin-NADP+ reductase activity
MF263_14025	COG0477	Major facilitator Superfamily
MF263_14045	COG2272	Belongs to the type-B carboxylesterase lipase family
MF263_14050	COG1960	acyl-CoA dehydrogenase activity
MF263_14075	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MF263_14095	COG2204	response regulator
MF263_14135	COG4964	Belongs to the GSP D family
MF263_14200	COG0612	Peptidase, M16
MF263_14205	COG0484	heat shock protein binding
MF263_14210	COG0443	Heat shock 70 kDa protein
MF263_14215	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
MF263_14220	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
MF263_14225	COG1420	regulation of RNA biosynthetic process
MF263_14235	COG0497	DNA recombination
MF263_14240	COG0735	belongs to the Fur family
MF263_14245	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
MF263_14250	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
MF263_14265	COG2267	carboxylic ester hydrolase activity
MF263_14275	COG0477	Major facilitator Superfamily
MF263_14280	COG1301	dicarboxylic acid transport
MF263_14290	COG0812	UDP-N-acetylmuramate dehydrogenase activity
MF263_14315	COG1538	Outer membrane efflux protein
MF263_14340	COG2814	Major facilitator Superfamily
MF263_14360	COG2814	Major facilitator Superfamily
MF263_14370	COG3383	formate dehydrogenase (NAD+) activity
MF263_14370	COG0243	molybdopterin cofactor binding
MF263_14375	COG0437	4 iron, 4 sulfur cluster binding
MF263_14380	COG2864	formate dehydrogenase
MF263_14385	COG3058	Necessary for formate dehydrogenase activity
MF263_14390	COG2819	hydrolase of the alpha beta superfamily
MF263_14395	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
MF263_14410	COG1454	alcohol dehydrogenase
MF263_14420	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
MF263_14445	COG1414	Transcriptional regulator
MF263_14450	COG0513	Belongs to the DEAD box helicase family
MF263_14460	COG0583	DNA-binding transcription factor activity
MF263_14465	COG4638	Rieske (2fe-2S)
MF263_14470	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
MF263_14485	COG0446	pyridine nucleotide-disulphide oxidoreductase
MF263_14500	COG3971	2-oxopent-4-enoate hydratase activity
MF263_14505	COG4569	acetaldehyde dehydrogenase (acetylating) activity
MF263_14515	COG2814	Major facilitator Superfamily
MF263_14535	COG3121	Chaperone
MF263_14545	COG0784	Response regulator, receiver
MF263_14545	COG2205	protein histidine kinase activity
MF263_14550	COG0784	Response regulator, receiver
MF263_14550	COG2205	protein histidine kinase activity
MF263_14555	COG2197	response regulator
MF263_14575	COG0154	amidase activity
MF263_14580	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MF263_14585	COG2814	Major facilitator Superfamily
MF263_14620	COG1028	Short-chain dehydrogenase reductase Sdr
MF263_14630	COG0842	Transport permease protein
MF263_14635	COG0842	Transport permease protein
MF263_14635	COG1129	ABC transporter
MF263_14640	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MF263_14645	COG1538	Outer membrane efflux protein
MF263_14650	COG3243	poly(R)-hydroxyalkanoic acid synthase
MF263_14660	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
MF263_14665	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
MF263_14675	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
MF263_14690	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
MF263_14705	COG0505	Belongs to the CarA family
MF263_14710	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
MF263_14720	COG0789	Transcriptional regulator
MF263_14735	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
MF263_14765	COG0697	spore germination
MF263_14780	COG3278	Belongs to the heme-copper respiratory oxidase family
MF263_14785	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MF263_14805	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
MF263_14855	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
MF263_14920	COG0517	IMP dehydrogenase activity
MF263_14920	COG0516	GMP reductase activity
MF263_14935	COG1027	Aspartate ammonia-lyase
MF263_14940	COG1846	Transcriptional regulator
MF263_14955	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
MF263_14960	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
MF263_14975	COG1414	Transcriptional regulator
MF263_14995	COG0513	Belongs to the DEAD box helicase family
MF263_15015	COG0429	hydrolase of the alpha beta-hydrolase fold
MF263_15040	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
MF263_15050	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
MF263_15060	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
MF263_15065	COG0632	four-way junction helicase activity
MF263_15075	COG2255	four-way junction helicase activity
MF263_15085	COG0418	dihydroorotase activity
MF263_15095	COG0415	Belongs to the DNA photolyase family
MF263_15160	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
MF263_15165	COG4654	Cytochrome c, class I
MF263_15205	COG1177	transmembrane transport
MF263_15210	COG3842	ATPase activity
MF263_15215	COG1840	ABC-type Fe3 transport system, periplasmic component
MF263_15220	COG2084	Dehydrogenase
MF263_15235	COG0494	nUDIX hydrolase
MF263_15240	COG0442	prolyl-tRNA aminoacylation
MF263_15245	COG0824	Thioesterase
MF263_15250	COG0811	peptide transport
MF263_15265	COG0823	Involved in the tonB-independent uptake of proteins
MF263_15280	COG0596	Alpha beta hydrolase
MF263_15305	COG1079	Belongs to the binding-protein-dependent transport system permease family
MF263_15310	COG4603	Belongs to the binding-protein-dependent transport system permease family
MF263_15315	COG3845	ABC transporter
MF263_15335	COG0427	acetyl-CoA hydrolase
MF263_15340	COG0583	DNA-binding transcription factor activity
MF263_15345	COG3634	alkyl hydroperoxide reductase activity
MF263_15360	COG0697	spore germination
MF263_15365	COG0175	sulfate reduction
MF263_15380	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
MF263_15395	COG0583	DNA-binding transcription factor activity
MF263_15400	COG1741	Belongs to the pirin family
MF263_15410	COG3706	GGDEF domain
MF263_15430	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
MF263_15440	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
MF263_15445	COG0284	orotidine-5'-phosphate decarboxylase activity
MF263_15460	COG1414	Transcriptional regulator
MF263_15470	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
MF263_15480	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
MF263_15485	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
MF263_15510	COG0742	ribosomal rna small subunit methyltransferase
MF263_15515	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
MF263_15520	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
MF263_15550	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
MF263_15565	COG1335	isochorismatase
MF263_15570	COG2309	aminopeptidase activity
MF263_15575	COG0596	Alpha beta hydrolase
MF263_15580	COG1529	Aldehyde oxidase and xanthine dehydrogenase
MF263_15580	COG2010	Cytochrome c
MF263_15585	COG2080	2 iron, 2 sulfur cluster binding
MF263_15590	COG1529	Aldehyde oxidase and xanthine dehydrogenase
MF263_15590	COG2010	Cytochrome c
MF263_15600	COG0410	ABC transporter
MF263_15605	COG0411	ABC transporter
MF263_15630	COG3706	GGDEF domain
MF263_15650	COG3181	Tripartite tricarboxylate transporter family receptor
MF263_15660	COG1234	tRNA 3'-trailer cleavage
MF263_15665	COG2188	Transcriptional regulator
MF263_15675	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
MF263_15685	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
MF263_15685	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
MF263_15690	COG3608	succinylglutamate desuccinylase aspartoacylase
MF263_15690	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
MF263_15695	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
MF263_15705	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
MF263_15710	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
MF263_15735	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
MF263_15760	COG1335	isochorismatase
MF263_15765	COG2309	aminopeptidase activity
MF263_15770	COG0596	Alpha beta hydrolase
MF263_15785	COG1120	ATPase activity
MF263_15790	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MF263_15800	COG4206	TonB-dependent receptor
MF263_15805	COG2031	fatty acid transporter
MF263_15810	COG0583	DNA-binding transcription factor activity
MF263_15815	COG0402	S-adenosylhomocysteine deaminase activity
MF263_15820	COG3181	Tripartite tricarboxylate transporter family receptor
MF263_15835	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
MF263_15840	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MF263_15845	COG0328	RNA-DNA hybrid ribonuclease activity
MF263_15850	COG2226	methyltransferase
MF263_15855	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MF263_15860	COG0741	lytic transglycosylase activity
MF263_15860	COG1388	LysM domain
MF263_15880	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
MF263_15905	COG2204	response regulator
MF263_15910	COG4191	Histidine kinase
MF263_15915	COG1301	dicarboxylic acid transport
MF263_15925	COG1054	Belongs to the UPF0176 family
MF263_15950	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
MF263_15970	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
MF263_15985	COG1028	Short-chain dehydrogenase reductase Sdr
MF263_15990	COG1877	trehalose-phosphatase activity
MF263_16025	COG0604	alcohol dehydrogenase
MF263_16035	COG1024	Enoyl-CoA hydratase
MF263_16055	COG2015	COG2015, Alkyl sulfatase and related hydrolases
MF263_16070	COG0604	alcohol dehydrogenase
MF263_16075	COG0583	DNA-binding transcription factor activity
MF263_16095	COG0583	DNA-binding transcription factor activity
MF263_16100	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
MF263_16105	COG1454	alcohol dehydrogenase
MF263_16115	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
MF263_16125	COG0583	DNA-binding transcription factor activity
MF263_16140	COG1280	lysine exporter protein (LysE YggA)
MF263_16150	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MF263_16165	COG1393	Belongs to the ArsC family
MF263_16170	COG0431	NADPH-dependent FMN reductase
MF263_16180	COG0642	Histidine kinase
MF263_16190	COG1917	Cupin 2, conserved barrel domain protein
MF263_16190	COG2207	Transcriptional regulator
MF263_16215	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
MF263_16215	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
MF263_16220	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
MF263_16225	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
MF263_16230	COG1881	PFAM PEBP family protein
MF263_16235	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
MF263_16240	COG0739	heme binding
MF263_16245	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
MF263_16250	COG0316	Belongs to the HesB IscA family
MF263_16260	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
MF263_16265	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
MF263_16270	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
MF263_16275	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
MF263_16280	COG0312	modulator of DNA gyrase
MF263_16285	COG3028	Belongs to the UPF0307 family
MF263_16315	COG2205	protein histidine kinase activity
MF263_16315	COG0745	RESPONSE REGULATOR receiver
MF263_16315	COG4191	Histidine kinase
MF263_16320	COG4566	intracellular signal transduction
MF263_16325	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
MF263_16355	COG0762	integral membrane protein
MF263_16360	COG2169	Transcriptional regulator
MF263_16360	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
MF263_16365	COG3133	Outer membrane lipoprotein
MF263_16370	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MF263_16385	COG0439	Biotin carboxylase
MF263_16390	COG0511	ligase activity, forming carbon-carbon bonds
MF263_16395	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
MF263_16405	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
MF263_16410	COG3150	esterase
MF263_16425	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
MF263_16430	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
MF263_16440	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
MF263_16455	COG1678	Uncharacterized ACR, COG1678
MF263_16470	COG0352	thiamine-phosphate diphosphorylase activity
MF263_16475	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
MF263_16490	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
MF263_16500	COG3237	CsbD-like
MF263_16505	COG0261	This protein binds to 23S rRNA in the presence of protein L20
MF263_16510	COG0211	Belongs to the bacterial ribosomal protein bL27 family
MF263_16515	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
MF263_16520	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
MF263_16545	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
MF263_16560	COG1126	abc transporter atp-binding protein
MF263_16565	COG0765	amino acid transport
MF263_16570	COG4597	amino acid ABC transporter
MF263_16575	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MF263_16580	COG2884	Cell division ATP-binding protein ftsE
MF263_16585	COG2177	Part of the ABC transporter FtsEX involved in
MF263_16595	COG0772	Belongs to the SEDS family
MF263_16600	COG0768	penicillin binding
MF263_16610	COG1792	Involved in formation and maintenance of cell shape
MF263_16615	COG1077	Cell shape determining protein MreB Mrl
MF263_16620	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
MF263_16625	COG0154	amidase activity
MF263_16630	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
MF263_16635	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
MF263_16640	COG0583	DNA-binding transcription factor activity
MF263_16645	COG2259	Doxx family
MF263_16650	COG3384	dioxygenase
MF263_16675	COG3604	Transcriptional regulator
MF263_16690	COG0786	glutamate:sodium symporter activity
MF263_16695	COG0142	geranyltranstransferase activity
MF263_16705	COG0494	nUDIX hydrolase
MF263_16710	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
MF263_16735	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
MF263_16740	COG0237	dephospho-CoA kinase activity
MF263_16755	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
MF263_16760	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
MF263_16770	COG0477	Major facilitator Superfamily
MF263_16785	COG4206	TonB-dependent receptor
MF263_16790	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
MF263_16825	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
MF263_16845	COG0598	Magnesium transport protein CorA
MF263_16860	COG2022	thiamine diphosphate biosynthetic process
MF263_16865	COG0351	phosphomethylpyrimidine kinase
MF263_16870	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
MF263_16875	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
MF263_16880	COG1538	Outer membrane efflux protein
MF263_16885	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
MF263_16895	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
MF263_16910	COG2226	methyltransferase
MF263_16915	COG0745	RESPONSE REGULATOR receiver
MF263_16930	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
MF263_16935	COG1984	allophanate hydrolase subunit 2
MF263_16940	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
MF263_16945	COG1238	metal cluster binding
MF263_16975	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
MF263_16980	COG4988	ABC transporter
MF263_16990	COG1294	oxidase, subunit
MF263_16995	COG1271	oxidase subunit
MF263_17010	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
MF263_17025	COG1137	ATPase activity
MF263_17035	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
MF263_17040	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
MF263_17045	COG1660	Displays ATPase and GTPase activities
MF263_17050	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
MF263_17055	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
MF263_17060	COG0792	nuclease activity
MF263_17065	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
MF263_17080	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
MF263_17100	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
MF263_17105	COG0793	Belongs to the peptidase S41A family
MF263_17115	COG0588	phosphoglycerate mutase activity
MF263_17120	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
MF263_17130	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
MF263_17135	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
MF263_17140	COG3181	Tripartite tricarboxylate transporter family receptor
MF263_17145	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
MF263_17150	COG1040	competence protein
MF263_17155	COG2226	methyltransferase
MF263_17160	COG4771	TonB-dependent receptor
MF263_17165	COG0745	RESPONSE REGULATOR receiver
MF263_17180	COG2204	response regulator
MF263_17200	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
MF263_17210	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
MF263_17215	COG3473	Maleate cis-trans isomerase
MF263_17230	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
MF263_17265	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
MF263_17305	COG0355	proton-transporting ATP synthase activity, rotational mechanism
MF263_17315	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
MF263_17320	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
MF263_17325	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
MF263_17340	COG0356	it plays a direct role in the translocation of protons across the membrane
MF263_17350	COG1024	Enoyl-CoA hydratase
MF263_17365	COG0037	tRNA processing
MF263_17370	COG0163	prenyltransferase activity
MF263_17375	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
MF263_17380	COG2890	protein-(glutamine-N5) methyltransferase activity
MF263_17400	COG0582	viral genome integration into host DNA
MF263_17415	COG2948	multi-organism process
MF263_17430	COG3846	protein secretion by the type IV secretion system
MF263_17440	COG3451	type IV secretory pathway VirB4
MF263_17455	COG4962	Type ii secretion system protein e
MF263_17470	COG0583	DNA-binding transcription factor activity
MF263_17545	COG5489	Protein of unknown function (DUF736)
MF263_17570	COG2003	Belongs to the UPF0758 family
MF263_17595	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
MF263_17630	COG0811	peptide transport
MF263_17660	COG3550	peptidyl-serine autophosphorylation
MF263_17700	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
MF263_17730	COG0811	peptide transport
MF263_17745	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
MF263_17750	COG2264	protein methyltransferase activity
MF263_17765	COG1595	DNA-templated transcription, initiation
MF263_17775	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
MF263_17800	COG3180	Ammonia monooxygenase
MF263_17820	COG5002	protein histidine kinase activity
MF263_17835	COG0477	Major facilitator Superfamily
MF263_17840	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
MF263_17890	COG0437	4 iron, 4 sulfur cluster binding
MF263_17895	COG2864	formate dehydrogenase
MF263_17905	COG1921	L-seryl-tRNASec selenium transferase activity
MF263_17910	COG3276	selenocysteine insertion sequence binding
MF263_17925	COG4771	TonB-dependent receptor
MF263_17940	COG0709	Synthesizes selenophosphate from selenide and ATP
MF263_17945	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
MF263_17950	COG0348	domain, Protein
MF263_17950	COG3901	Regulator of nitric oxide reductase transcription
MF263_17955	COG4263	nitrous-oxide reductase activity
MF263_17970	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
MF263_17985	COG0166	Belongs to the GPI family
MF263_18030	COG2233	PERMEase
MF263_18035	COG0697	spore germination
MF263_18040	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MF263_18045	COG0697	spore germination
MF263_18065	COG2885	chlorophyll binding
MF263_18160	COG0183	Belongs to the thiolase family
MF263_18165	COG1250	3-hydroxyacyl-CoA dehydrogenase
MF263_18165	COG1024	Enoyl-CoA hydratase
MF263_18180	COG1127	ABC transporter
MF263_18185	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
MF263_18190	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
MF263_18205	COG1131	(ABC) transporter
MF263_18210	COG0842	Transport permease protein
MF263_18220	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
MF263_18230	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
MF263_18235	COG0131	Imidazoleglycerol-phosphate dehydratase
MF263_18245	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
MF263_18250	COG0107	imidazoleglycerol-phosphate synthase activity
MF263_18260	COG0140	phosphoribosyl-ATP diphosphatase activity
MF263_18265	COG0537	adenosine 5'-monophosphoramidase activity
MF263_18270	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
MF263_18275	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
MF263_18285	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MF263_18295	COG1970	mechanosensitive ion channel activity
MF263_18300	COG0723	plastoquinol--plastocyanin reductase activity
MF263_18305	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
MF263_18310	COG2857	Cytochrome c1
MF263_18315	COG0625	glutathione transferase activity
MF263_18320	COG2969	positive regulation of protein catabolic process
MF263_18325	COG4208	sulfate ABC transporter
MF263_18330	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
MF263_18335	COG4150	thiosulfate binding
MF263_18350	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
MF263_18370	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
MF263_18375	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
MF263_18390	COG0129	dihydroxy-acid dehydratase activity
MF263_18395	COG1802	Transcriptional regulator
MF263_18400	COG1522	sequence-specific DNA binding
MF263_18410	COG3483	tryptophan 2,3-dioxygenase activity
MF263_18430	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
MF263_18435	COG0656	L-ascorbic acid biosynthetic process
MF263_18445	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
MF263_18450	COG3706	GGDEF domain
MF263_18455	COG2226	methyltransferase
MF263_18480	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
MF263_18485	COG0583	DNA-binding transcription factor activity
MF263_18490	COG0477	Major facilitator Superfamily
MF263_18495	COG1028	Short-chain dehydrogenase reductase Sdr
MF263_18505	COG1335	isochorismatase
MF263_18510	COG1335	isochorismatase
MF263_18530	COG2823	Periplasmic or secreted lipoprotein
MF263_18540	COG3284	Transcriptional regulator
MF263_18545	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
MF263_18550	COG0583	DNA-binding transcription factor activity
MF263_18585	COG1595	DNA-templated transcription, initiation
MF263_18595	COG1522	sequence-specific DNA binding
MF263_18605	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
MF263_18625	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
MF263_18665	COG0109	protoheme IX farnesyltransferase activity
MF263_18685	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
MF263_18705	COG3568	Endonuclease Exonuclease Phosphatase
MF263_18710	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
MF263_18735	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MF263_18745	COG1228	amidohydrolase
MF263_18765	COG2986	histidine ammonia-lyase
MF263_18770	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
MF263_18790	COG0477	Major facilitator Superfamily
MF263_18795	COG0583	DNA-binding transcription factor activity
MF263_18805	COG0789	Transcriptional regulator
MF263_18835	COG0625	glutathione transferase activity
MF263_18845	COG1017	nitric oxide dioxygenase activity
MF263_18845	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
MF263_18865	COG2365	Tyrosine phosphatase family
MF263_18870	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
MF263_18890	COG2423	ornithine cyclodeaminase activity
MF263_18940	COG3069	C4-dicarboxylate transmembrane transporter activity
MF263_18950	COG1802	Transcriptional regulator
MF263_18955	COG1309	transcriptional regulator
MF263_18960	COG2814	Major facilitator Superfamily
MF263_18980	COG2814	Major facilitator Superfamily
MF263_18985	COG0251	oxidation-reduction process
MF263_18990	COG3181	Tripartite tricarboxylate transporter family receptor
MF263_18995	COG0179	Fumarylacetoacetate (FAA) hydrolase
MF263_19000	COG2186	Transcriptional regulator
MF263_19005	COG1595	DNA-templated transcription, initiation
MF263_19010	COG3712	iron ion homeostasis
MF263_19025	COG2814	Major facilitator Superfamily
MF263_19035	COG0232	Belongs to the dGTPase family. Type 2 subfamily
MF263_19040	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
MF263_19045	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
MF263_19065	COG5001	Diguanylate cyclase
MF263_19065	COG5002	protein histidine kinase activity
MF263_19070	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
MF263_19075	COG1333	cytochrome c biogenesis protein
MF263_19085	COG0218	Necessary for normal cell division and for the maintenance of normal septation
MF263_19090	COG0113	porphobilinogen synthase activity
MF263_19095	COG4232	protein-disulfide reductase activity
MF263_19115	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MF263_19120	COG0203	ribosomal protein L17
MF263_19125	COG0202	RNA polymerase activity
MF263_19130	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
MF263_19135	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
MF263_19140	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
MF263_19145	COG0257	Belongs to the bacterial ribosomal protein bL36 family
MF263_19155	COG0201	protein transport
MF263_19160	COG0200	Binds to the 23S rRNA
MF263_19165	COG1841	ribosomal large subunit assembly
MF263_19170	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
MF263_19175	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
MF263_19180	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
MF263_19185	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
MF263_19190	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
MF263_19195	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
MF263_19200	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
MF263_19205	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
MF263_19255	COG1538	Outer membrane efflux protein
MF263_19270	COG1960	acyl-CoA dehydrogenase activity
MF263_19275	COG0183	Belongs to the thiolase family
MF263_19285	COG2067	long-chain fatty acid transport protein
MF263_19300	COG0318	PFAM AMP-dependent synthetase and ligase
MF263_19305	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
MF263_19310	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
MF263_19315	COG1648	precorrin-2 dehydrogenase activity
MF263_19315	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
MF263_19330	COG1116	anion transmembrane transporter activity
MF263_19335	COG1960	acyl-CoA dehydrogenase activity
MF263_19350	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
MF263_19355	COG0255	Belongs to the universal ribosomal protein uL29 family
MF263_19360	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
MF263_19365	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
MF263_19370	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
MF263_19375	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
MF263_19380	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
MF263_19385	COG0089	rRNA binding
MF263_19390	COG0088	Forms part of the polypeptide exit tunnel
MF263_19395	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
MF263_19400	COG4175	Glycine betaine
MF263_19405	COG4176	ABC-type proline glycine betaine transport system permease component
MF263_19410	COG0051	transcription antitermination factor activity, RNA binding
MF263_19415	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
MF263_19420	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
MF263_19425	COG0049	tRNA binding
MF263_19430	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
MF263_19460	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
MF263_19465	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
MF263_19470	COG0085	RNA polymerase activity
MF263_19475	COG0222	ribosome binding
MF263_19480	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
MF263_19485	COG0081	regulation of translation
MF263_19510	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
MF263_19530	COG1475	DNA binding
MF263_19535	COG1192	Involved in chromosome partitioning
MF263_19540	COG0357	Ribosomal RNA small subunit methyltransferase G
MF263_19545	COG0445	tRNA wobble uridine modification
MF263_19550	COG0436	Aminotransferase
MF263_19560	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
MF263_19565	COG3706	GGDEF domain
MF263_19570	COG0688	phosphatidylethanolamine metabolic process
MF263_19580	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
MF263_19625	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
MF263_19660	COG0559	Belongs to the binding-protein-dependent transport system permease family
MF263_19680	COG0596	Alpha beta hydrolase
MF263_19685	COG2309	aminopeptidase activity
MF263_19690	COG1335	isochorismatase
MF263_19715	COG0753	catalase activity
MF263_19725	COG0745	RESPONSE REGULATOR receiver
MF263_19730	COG2205	protein histidine kinase activity
MF263_19745	COG1136	(ABC) transporter
MF263_19755	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
MF263_19785	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
MF263_19790	COG0706	membrane insertase activity
MF263_19795	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
MF263_19800	COG0594	ribonuclease P activity
MF263_19805	COG0230	Belongs to the bacterial ribosomal protein bL34 family