locus-tag	class	description
UZ73_00020	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
UZ73_00025	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
UZ73_00110	COG2003	Belongs to the UPF0758 family
UZ73_00220	COG1028	Short-chain dehydrogenase reductase Sdr
UZ73_00250	COG3038	cytochrome b561
UZ73_00265	COG1393	Belongs to the ArsC family
UZ73_00270	COG0625	glutathione transferase activity
UZ73_00290	COG0084	hydrolase, TatD family'
UZ73_00295	COG0470	DNA polymerase III
UZ73_00305	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
UZ73_00325	COG1960	acyl-CoA dehydrogenase activity
UZ73_00330	COG2914	Belongs to the UPF0125 (RnfH) family
UZ73_00335	COG2867	negative regulation of translational initiation
UZ73_00340	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
UZ73_00345	COG1252	NADH dehydrogenase
UZ73_00360	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
UZ73_00370	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
UZ73_00375	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
UZ73_00380	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
UZ73_00390	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
UZ73_00395	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
UZ73_00405	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
UZ73_00415	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
UZ73_00420	COG0575	Belongs to the CDS family
UZ73_00425	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
UZ73_00430	COG0233	cytoplasmic translational termination
UZ73_00435	COG0528	UMP kinase activity
UZ73_00440	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
UZ73_00445	COG0052	Belongs to the universal ribosomal protein uS2 family
UZ73_00450	COG0024	Methionine aminopeptidase
UZ73_00455	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
UZ73_00480	COG1286	toxin biosynthetic process
UZ73_00490	COG0285	dihydrofolate synthase activity
UZ73_00495	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
UZ73_00500	COG0508	dehydrogenase complex catalyzes the overall conversion of
UZ73_00505	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
UZ73_00520	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
UZ73_00530	COG1999	signal sequence binding
UZ73_00535	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
UZ73_00540	COG0640	Transcriptional regulator
UZ73_00555	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
UZ73_00560	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
UZ73_00565	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
UZ73_00570	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
UZ73_00575	COG1028	Short-chain dehydrogenase reductase Sdr
UZ73_00580	COG1028	Short-chain dehydrogenase reductase Sdr
UZ73_00600	COG0183	Belongs to the thiolase family
UZ73_00620	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
UZ73_00630	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
UZ73_00635	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
UZ73_00640	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
UZ73_00660	COG0183	Belongs to the thiolase family
UZ73_00665	COG0183	Belongs to the thiolase family
UZ73_00675	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
UZ73_00680	COG0583	DNA-binding transcription factor activity
UZ73_00685	COG1982	Orn Lys Arg decarboxylase major
UZ73_00710	COG0194	GDP metabolic process
UZ73_00715	COG1758	RNA polymerase activity
UZ73_00720	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
UZ73_00730	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
UZ73_00735	COG0739	heme binding
UZ73_00740	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
UZ73_00745	COG0584	glycerophosphoryl diester phosphodiesterase
UZ73_00750	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
UZ73_00755	COG1187	pseudouridine synthase activity
UZ73_00760	COG3161	chorismate lyase activity
UZ73_00765	COG2814	Major facilitator Superfamily
UZ73_00770	COG0656	L-ascorbic acid biosynthetic process
UZ73_00780	COG0668	transmembrane transport
UZ73_00785	COG0165	Argininosuccinate lyase
UZ73_00800	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
UZ73_00810	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
UZ73_00820	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
UZ73_00825	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
UZ73_00830	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
UZ73_00835	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
UZ73_00840	COG2252	PERMEase
UZ73_00845	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
UZ73_00865	COG0488	(ABC) transporter
UZ73_00870	COG1619	proteins homologs of microcin C7 resistance protein MccF
UZ73_00875	COG0590	tRNA wobble adenosine to inosine editing
UZ73_00880	COG1131	(ABC) transporter
UZ73_00885	COG0842	Transport permease protein
UZ73_00900	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
UZ73_00905	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
UZ73_00910	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
UZ73_00920	COG2022	thiamine diphosphate biosynthetic process
UZ73_00940	COG1414	Transcriptional regulator
UZ73_00950	COG0730	response to heat
UZ73_00960	COG1666	GTP binding
UZ73_00965	COG0318	PFAM AMP-dependent synthetase and ligase
UZ73_00970	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
UZ73_00975	COG0519	Catalyzes the synthesis of GMP from XMP
UZ73_00975	COG0518	GMP synthase (glutamine-hydrolyzing) activity
UZ73_00980	COG2207	Transcriptional regulator
UZ73_00990	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
UZ73_00995	COG0135	phosphoribosylanthranilate isomerase activity
UZ73_01000	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
UZ73_01010	COG0101	tRNA pseudouridine synthase activity
UZ73_01020	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
UZ73_01025	COG0473	3-isopropylmalate dehydrogenase activity
UZ73_01030	COG0066	3-isopropylmalate dehydratase activity
UZ73_01035	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
UZ73_01045	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
UZ73_01055	COG4566	intracellular signal transduction
UZ73_01070	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
UZ73_01075	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
UZ73_01085	COG1295	ribonuclease BN
UZ73_01095	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
UZ73_01110	COG1538	Outer membrane efflux protein
UZ73_01115	COG0577	efflux transmembrane transporter activity
UZ73_01115	COG1136	(ABC) transporter
UZ73_01120	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
UZ73_01165	COG4964	Belongs to the GSP D family
UZ73_01200	COG3712	iron ion homeostasis
UZ73_01205	COG1595	DNA-templated transcription, initiation
UZ73_01215	COG4774	siderophore transport
UZ73_01220	COG3712	iron ion homeostasis
UZ73_01235	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
UZ73_01245	COG2959	enzyme of heme biosynthesis
UZ73_01255	COG0181	hydroxymethylbilane synthase activity
UZ73_01260	COG0861	Integral membrane protein TerC family
UZ73_01265	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
UZ73_01270	COG0045	succinate-CoA ligase (ADP-forming) activity
UZ73_01280	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
UZ73_01285	COG0583	DNA-binding transcription factor activity
UZ73_01290	COG2137	regulation of response to DNA damage stimulus
UZ73_01295	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
UZ73_01310	COG0477	Major facilitator Superfamily
UZ73_01325	COG0318	PFAM AMP-dependent synthetase and ligase
UZ73_01330	COG1024	Enoyl-CoA hydratase
UZ73_01335	COG3162	membrane
UZ73_01350	COG0540	Belongs to the ATCase OTCase family
UZ73_01365	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
UZ73_01370	COG2373	Large extracellular alpha-helical protein
UZ73_01380	COG2070	2-Nitropropane dioxygenase
UZ73_01390	COG2111	Na H antiporter
UZ73_01390	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
UZ73_01395	COG1006	Multisubunit Na H antiporter MnhC subunit
UZ73_01400	COG0651	ATP synthesis coupled electron transport
UZ73_01410	COG2212	antiporter activity
UZ73_01425	COG0477	Major facilitator Superfamily
UZ73_01450	COG3158	transport of potassium into the cell
UZ73_01455	COG0642	Histidine kinase
UZ73_01460	COG0745	RESPONSE REGULATOR receiver
UZ73_01480	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
UZ73_01485	COG4208	sulfate ABC transporter
UZ73_01490	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
UZ73_01495	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
UZ73_01510	COG1278	Cold shock
UZ73_01520	COG0776	regulation of translation
UZ73_01525	COG1648	precorrin-2 dehydrogenase activity
UZ73_01525	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
UZ73_01530	COG2010	Cytochrome c
UZ73_01565	COG1648	precorrin-2 dehydrogenase activity
UZ73_01565	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
UZ73_01575	COG2010	Cytochrome c
UZ73_01580	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
UZ73_01585	COG0626	cystathionine gamma-synthase activity
UZ73_01590	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
UZ73_01595	COG0557	exoribonuclease II activity
UZ73_01620	COG0765	amino acid transport
UZ73_01625	COG1126	abc transporter atp-binding protein
UZ73_01640	COG1850	ribulose-bisphosphate carboxylase activity
UZ73_01660	COG2375	cellular response to nickel ion
UZ73_01695	COG0583	DNA-binding transcription factor activity
UZ73_01700	COG3842	ATPase activity
UZ73_01705	COG1175	transmembrane transport
UZ73_01710	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
UZ73_01715	COG1840	ABC-type Fe3 transport system, periplasmic component
UZ73_01750	COG0412	Dienelactone hydrolase
UZ73_01755	COG3530	Putative quorum-sensing-regulated virulence factor
UZ73_01760	COG0625	glutathione transferase activity
UZ73_01770	COG1741	Belongs to the pirin family
UZ73_01780	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
UZ73_01785	COG2814	Major facilitator Superfamily
UZ73_01790	COG2807	transmembrane transport
UZ73_01795	COG2207	Transcriptional regulator
UZ73_01800	COG3135	benzoate transporter
UZ73_01810	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
UZ73_01825	COG1529	Aldehyde oxidase and xanthine dehydrogenase
UZ73_01835	COG0402	S-adenosylhomocysteine deaminase activity
UZ73_01845	COG0745	RESPONSE REGULATOR receiver
UZ73_01850	COG2205	protein histidine kinase activity
UZ73_01855	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
UZ73_01865	COG0828	Belongs to the bacterial ribosomal protein bS21 family
UZ73_01870	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
UZ73_01875	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
UZ73_01880	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
UZ73_01885	COG0330	HflC and HflK could
UZ73_01890	COG0330	HflC and HflK could
UZ73_01895	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
UZ73_01900	COG1923	regulation of RNA biosynthetic process
UZ73_01910	COG1160	GTP binding
UZ73_01915	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
UZ73_01920	COG2976	Protein conserved in bacteria
UZ73_01925	COG0124	histidyl-tRNA synthetase
UZ73_01930	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
UZ73_01940	COG0820	rRNA (adenine-C2-)-methyltransferase activity
UZ73_01945	COG0105	UTP biosynthetic process
UZ73_01955	COG0583	DNA-binding transcription factor activity
UZ73_01965	COG0336	Belongs to the RNA methyltransferase TrmD family
UZ73_01970	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
UZ73_01975	COG0228	four-way junction DNA binding
UZ73_01980	COG0425	Belongs to the sulfur carrier protein TusA family
UZ73_01985	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
UZ73_02000	COG2351	hydroxyisourate hydrolase activity
UZ73_02030	COG1653	transport
UZ73_02035	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
UZ73_02050	COG0187	DNA topoisomerase II activity
UZ73_02060	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
UZ73_02065	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
UZ73_02095	COG0601	transmembrane transport
UZ73_02125	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
UZ73_02130	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
UZ73_02135	COG0542	response to heat
UZ73_02140	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
UZ73_02155	COG0348	domain, Protein
UZ73_02175	COG3278	Belongs to the heme-copper respiratory oxidase family
UZ73_02185	COG2217	Heavy metal translocating P-type atpase
UZ73_02190	COG2224	Isocitrate lyase
UZ73_02195	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
UZ73_02195	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
UZ73_02210	COG0322	excinuclease ABC activity
UZ73_02215	COG1472	Belongs to the glycosyl hydrolase 3 family
UZ73_02220	COG0736	holo-[acyl-carrier-protein] synthase activity
UZ73_02230	COG2050	protein possibly involved in aromatic compounds catabolism
UZ73_02235	COG1024	Enoyl-CoA hydratase
UZ73_02240	COG1012	belongs to the aldehyde dehydrogenase family
UZ73_02245	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
UZ73_02250	COG2151	metal-sulfur cluster biosynthetic enzyme
UZ73_02255	COG3396	Phenylacetate-CoA oxygenase
UZ73_02260	COG3460	Phenylacetate-CoA oxygenase
UZ73_02265	COG3396	Phenylacetate-CoA oxygenase
UZ73_02270	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
UZ73_02275	COG0501	Belongs to the peptidase M48B family
UZ73_02280	COG1162	GTPase activity
UZ73_02290	COG0335	large ribosomal subunit rRNA binding
UZ73_02310	COG0450	alkyl hydroperoxide reductase
UZ73_02315	COG1960	acyl-CoA dehydrogenase activity
UZ73_02330	COG0123	including yeast histone deacetylase and acetoin utilization protein
UZ73_02335	COG2951	lytic endotransglycosylase activity
UZ73_02345	COG1596	polysaccharide export
UZ73_02345	COG1555	photosystem II stabilization
UZ73_02350	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
UZ73_02355	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
UZ73_02360	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
UZ73_02380	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
UZ73_02385	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
UZ73_02390	COG0287	Prephenate dehydrogenase
UZ73_02400	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
UZ73_02415	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
UZ73_02435	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
UZ73_02455	COG0753	catalase activity
UZ73_02465	COG4335	DNA alkylation repair
UZ73_02475	COG0436	Aminotransferase
UZ73_02485	COG0251	oxidation-reduction process
UZ73_02490	COG1309	transcriptional regulator
UZ73_02505	COG0488	(ABC) transporter
UZ73_02550	COG3634	alkyl hydroperoxide reductase activity
UZ73_02555	COG0625	glutathione transferase activity
UZ73_02560	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
UZ73_02565	COG1280	lysine exporter protein (LysE YggA)
UZ73_02585	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
UZ73_02595	COG5002	protein histidine kinase activity
UZ73_02605	COG2046	Belongs to the sulfate adenylyltransferase family
UZ73_02610	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
UZ73_02625	COG0840	transmembrane signaling receptor activity
UZ73_02630	COG2119	membrane
UZ73_02645	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
UZ73_02650	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
UZ73_02665	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
UZ73_02670	COG2321	neutral zinc metallopeptidase
UZ73_02685	COG2175	clavaminate synthase activity
UZ73_02690	COG1846	Transcriptional regulator
UZ73_02700	COG0347	Belongs to the P(II) protein family
UZ73_02705	COG0004	ammonium transporteR
UZ73_02710	COG3909	cytochrome
UZ73_02720	COG0625	glutathione transferase activity
UZ73_02730	COG0657	acetylesterase activity
UZ73_02735	COG0730	response to heat
UZ73_02740	COG0482	sulfurtransferase activity
UZ73_02745	COG0277	FAD linked oxidase domain protein
UZ73_02750	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
UZ73_02755	COG2879	small protein
UZ73_02760	COG1966	Carbon starvation protein
UZ73_02765	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
UZ73_02770	COG0765	amino acid transport
UZ73_02775	COG0765	amino acid transport
UZ73_02780	COG1126	abc transporter atp-binding protein
UZ73_02785	COG0028	Belongs to the TPP enzyme family
UZ73_02790	COG1012	belongs to the aldehyde dehydrogenase family
UZ73_02795	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
UZ73_02800	COG1028	Short-chain dehydrogenase reductase Sdr
UZ73_02805	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
UZ73_02805	COG2226	methyltransferase
UZ73_02805	COG0596	Alpha beta hydrolase
UZ73_02810	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
UZ73_02815	COG1116	anion transmembrane transporter activity
UZ73_02830	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
UZ73_02845	COG5285	phytanoyl-CoA dioxygenase
UZ73_02850	COG0662	Cupin 2, conserved barrel domain protein
UZ73_02855	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
UZ73_02860	COG0456	acetyltransferase
UZ73_02865	COG1846	Transcriptional regulator
UZ73_02875	COG0312	modulator of DNA gyrase
UZ73_02890	COG0308	aminopeptidase N
UZ73_02895	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
UZ73_02910	COG0473	3-isopropylmalate dehydrogenase activity
UZ73_02920	COG0433	COG0433 Predicted ATPase
UZ73_02925	COG0217	transcriptional regulatory protein
UZ73_02930	COG0151	Belongs to the GarS family
UZ73_02935	COG0408	coproporphyrinogen oxidase activity
UZ73_02940	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
UZ73_02945	COG0799	negative regulation of ribosome biogenesis
UZ73_02950	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
UZ73_02955	COG0424	maF-like protein
UZ73_02975	COG0023	Translation Initiation Factor
UZ73_02985	COG2084	Dehydrogenase
UZ73_02990	COG0625	glutathione transferase activity
UZ73_02995	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
UZ73_03000	COG1047	Peptidyl-prolyl cis-trans
UZ73_03005	COG2003	Belongs to the UPF0758 family
UZ73_03010	COG1737	Transcriptional regulator
UZ73_03015	COG0477	Major facilitator Superfamily
UZ73_03025	COG2271	Major facilitator Superfamily
UZ73_03030	COG0254	rRNA binding
UZ73_03040	COG0534	Mate efflux family protein
UZ73_03045	COG4175	Glycine betaine
UZ73_03050	COG4176	ABC-type proline glycine betaine transport system permease component
UZ73_03060	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
UZ73_03065	COG2814	Major facilitator Superfamily
UZ73_03070	COG0227	Belongs to the bacterial ribosomal protein bL28 family
UZ73_03075	COG0267	Belongs to the bacterial ribosomal protein bL33 family
UZ73_03080	COG0495	leucyl-tRNA aminoacylation
UZ73_03090	COG1466	dna polymerase III delta subunit
UZ73_03095	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
UZ73_03115	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
UZ73_03125	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
UZ73_03130	COG0148	phosphopyruvate hydratase activity
UZ73_03140	COG2814	Major facilitator Superfamily
UZ73_03165	COG0504	CTP synthase activity
UZ73_03200	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
UZ73_03210	COG0791	NLP P60 protein
UZ73_03220	COG0583	DNA-binding transcription factor activity
UZ73_03230	COG0583	DNA-binding transcription factor activity
UZ73_03240	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
UZ73_03255	COG1045	serine acetyltransferase
UZ73_03270	COG1381	Involved in DNA repair and RecF pathway recombination
UZ73_03275	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
UZ73_03280	COG0571	ribonuclease III activity
UZ73_03290	COG0481	GTPase activity
UZ73_03295	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
UZ73_03315	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
UZ73_03325	COG1028	Short-chain dehydrogenase reductase Sdr
UZ73_03330	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
UZ73_03335	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
UZ73_03340	COG0416	fatty acid biosynthetic process
UZ73_03345	COG0333	Belongs to the bacterial ribosomal protein bL32 family
UZ73_03350	COG1399	metal-binding, possibly nucleic acid-binding protein
UZ73_03355	COG0424	maF-like protein
UZ73_03365	COG3023	N-Acetylmuramoyl-L-alanine amidase
UZ73_03370	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
UZ73_03375	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
UZ73_03380	COG0546	phosphoglycolate phosphatase activity
UZ73_03385	COG0564	pseudouridine synthase activity
UZ73_03390	COG1530	ribonuclease E activity
UZ73_03395	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
UZ73_03400	COG0159	tryptophan synthase activity
UZ73_03405	COG0133	tryptophan synthase activity
UZ73_03410	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
UZ73_03420	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
UZ73_03425	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
UZ73_03435	COG2878	Part of a membrane complex involved in electron transport
UZ73_03440	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
UZ73_03445	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
UZ73_03450	COG3047	cAMP biosynthetic process
UZ73_03460	COG0411	ABC transporter
UZ73_03475	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
UZ73_03480	COG2917	probably involved in intracellular septation
UZ73_03490	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
UZ73_03495	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
UZ73_03505	COG1196	nuclear chromosome segregation
UZ73_03510	COG0477	Major facilitator Superfamily
UZ73_03515	COG1573	uracil-dna glycosylase
UZ73_03520	COG1214	PFAM Peptidase M22, glycoprotease
UZ73_03525	COG0745	RESPONSE REGULATOR receiver
UZ73_03530	COG2205	protein histidine kinase activity
UZ73_03540	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
UZ73_03545	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
UZ73_03550	COG0560	Phosphoserine phosphatase
UZ73_03565	COG1007	ATP synthesis coupled electron transport
UZ73_03580	COG0713	ATP synthesis coupled electron transport
UZ73_03590	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
UZ73_03595	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
UZ73_03600	COG1034	ATP synthesis coupled electron transport
UZ73_03615	COG0649	NAD binding
UZ73_03620	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
UZ73_03625	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
UZ73_03630	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
UZ73_03635	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
UZ73_03650	COG0149	triose-phosphate isomerase activity
UZ73_03655	COG0604	alcohol dehydrogenase
UZ73_03675	COG1185	polyribonucleotide nucleotidyltransferase activity
UZ73_03680	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
UZ73_03685	COG1183	phosphatidylcholine synthase activity
UZ73_03690	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
UZ73_03695	COG0440	acetolactate synthase activity
UZ73_03700	COG0028	Belongs to the TPP enzyme family
UZ73_03705	COG1289	transmembrane transporter activity
UZ73_03710	COG3022	response to hydroperoxide
UZ73_03715	COG1028	Short-chain dehydrogenase reductase Sdr
UZ73_03740	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
UZ73_03745	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
UZ73_03750	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
UZ73_03755	COG1674	ftsk spoiiie
UZ73_03760	COG0492	ferredoxin-NADP+ reductase activity
UZ73_03780	COG0477	Major facilitator Superfamily
UZ73_03800	COG2272	Belongs to the type-B carboxylesterase lipase family
UZ73_03805	COG1960	acyl-CoA dehydrogenase activity
UZ73_03830	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
UZ73_03850	COG2204	response regulator
UZ73_03890	COG4964	Belongs to the GSP D family
UZ73_03950	COG0612	Peptidase, M16
UZ73_03955	COG0484	heat shock protein binding
UZ73_03960	COG0443	Heat shock 70 kDa protein
UZ73_03965	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
UZ73_03970	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
UZ73_03975	COG1420	regulation of RNA biosynthetic process
UZ73_03980	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
UZ73_03985	COG0497	DNA recombination
UZ73_03990	COG0735	belongs to the Fur family
UZ73_03995	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
UZ73_04000	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
UZ73_04015	COG2267	carboxylic ester hydrolase activity
UZ73_04025	COG0477	Major facilitator Superfamily
UZ73_04030	COG1301	dicarboxylic acid transport
UZ73_04040	COG0812	UDP-N-acetylmuramate dehydrogenase activity
UZ73_04075	COG1538	Outer membrane efflux protein
UZ73_04095	COG2271	Major facilitator Superfamily
UZ73_04110	COG2814	Major facilitator Superfamily
UZ73_04120	COG0243	molybdopterin cofactor binding
UZ73_04120	COG3383	formate dehydrogenase (NAD+) activity
UZ73_04125	COG0437	4 iron, 4 sulfur cluster binding
UZ73_04130	COG2864	formate dehydrogenase
UZ73_04135	COG3058	Necessary for formate dehydrogenase activity
UZ73_04140	COG2819	hydrolase of the alpha beta superfamily
UZ73_04160	COG1454	alcohol dehydrogenase
UZ73_04170	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
UZ73_04180	COG0559	Belongs to the binding-protein-dependent transport system permease family
UZ73_04195	COG1414	Transcriptional regulator
UZ73_04200	COG0513	Belongs to the DEAD box helicase family
UZ73_04205	COG0583	DNA-binding transcription factor activity
UZ73_04210	COG4638	Rieske (2fe-2S)
UZ73_04215	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
UZ73_04230	COG0446	pyridine nucleotide-disulphide oxidoreductase
UZ73_04250	COG4569	acetaldehyde dehydrogenase (acetylating) activity
UZ73_04255	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
UZ73_04260	COG2814	Major facilitator Superfamily
UZ73_04280	COG3121	Chaperone
UZ73_04290	COG0784	Response regulator, receiver
UZ73_04290	COG2205	protein histidine kinase activity
UZ73_04295	COG0784	Response regulator, receiver
UZ73_04295	COG2205	protein histidine kinase activity
UZ73_04300	COG2197	response regulator
UZ73_04305	COG2199	diguanylate cyclase activity
UZ73_04305	COG2203	Gaf domain
UZ73_04305	COG2200	EAL domain
UZ73_04315	COG0154	amidase activity
UZ73_04320	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
UZ73_04325	COG2814	Major facilitator Superfamily
UZ73_04360	COG1028	Short-chain dehydrogenase reductase Sdr
UZ73_04370	COG0842	Transport permease protein
UZ73_04375	COG0842	Transport permease protein
UZ73_04375	COG1129	ABC transporter
UZ73_04380	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
UZ73_04390	COG3243	poly(R)-hydroxyalkanoic acid synthase
UZ73_04400	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
UZ73_04405	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
UZ73_04415	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
UZ73_04430	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
UZ73_04445	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
UZ73_04450	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
UZ73_04460	COG0789	Transcriptional regulator
UZ73_04470	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
UZ73_04515	COG3278	Belongs to the heme-copper respiratory oxidase family
UZ73_04520	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
UZ73_04590	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
UZ73_04655	COG0516	GMP reductase activity
UZ73_04655	COG0517	IMP dehydrogenase activity
UZ73_04670	COG1027	Aspartate ammonia-lyase
UZ73_04675	COG1846	Transcriptional regulator
UZ73_04690	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
UZ73_04695	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
UZ73_04710	COG1414	Transcriptional regulator
UZ73_04730	COG0513	Belongs to the DEAD box helicase family
UZ73_04750	COG0429	hydrolase of the alpha beta-hydrolase fold
UZ73_04755	COG4783	chaperone-mediated protein folding
UZ73_04775	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
UZ73_04785	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
UZ73_04795	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
UZ73_04800	COG0632	four-way junction helicase activity
UZ73_04810	COG2255	four-way junction helicase activity
UZ73_04820	COG0418	dihydroorotase activity
UZ73_04830	COG0415	Belongs to the DNA photolyase family
UZ73_04870	COG1530	ribonuclease E activity
UZ73_04885	COG1132	(ABC) transporter
UZ73_04910	COG0438	transferase activity, transferring glycosyl groups
UZ73_04925	COG0726	polysaccharide deacetylase
UZ73_04930	COG0438	transferase activity, transferring glycosyl groups
UZ73_04940	COG1643	Atp-dependent helicase
UZ73_04945	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
UZ73_04945	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
UZ73_04950	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
UZ73_04955	COG0659	secondary active sulfate transmembrane transporter activity
UZ73_04960	COG3706	GGDEF domain
UZ73_04960	COG2203	Gaf domain
UZ73_04960	COG5001	Diguanylate cyclase
UZ73_04960	COG4251	negative regulation of phosphorylation
UZ73_04965	COG0704	Plays a role in the regulation of phosphate uptake
UZ73_04970	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
UZ73_04975	COG1393	Belongs to the ArsC family
UZ73_04980	COG1177	transmembrane transport
UZ73_04985	COG1176	ABC-type spermidine putrescine transport system, permease component I
UZ73_04990	COG3842	ATPase activity
UZ73_05015	COG1028	Short-chain dehydrogenase reductase Sdr
UZ73_05020	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
UZ73_05025	COG1562	ergosterol biosynthetic process
UZ73_05030	COG1562	ergosterol biosynthetic process
UZ73_05040	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
UZ73_05055	COG0436	Aminotransferase
UZ73_05065	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
UZ73_05070	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
UZ73_05075	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
UZ73_05085	COG0305	Participates in initiation and elongation during chromosome replication
UZ73_05090	COG0359	binds to the 23S rRNA
UZ73_05095	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
UZ73_05100	COG2965	DNA replication, synthesis of RNA primer
UZ73_05105	COG0360	Binds together with S18 to 16S ribosomal RNA
UZ73_05110	COG1469	GTP cyclohydrolase I activity
UZ73_05115	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
UZ73_05120	COG0142	geranyltranstransferase activity
UZ73_05125	COG1722	exodeoxyribonuclease VII activity
UZ73_05140	COG0501	Belongs to the peptidase M48B family
UZ73_05145	COG0456	acetyltransferase
UZ73_05155	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
UZ73_05165	COG1283	sodium-dependent phosphate transmembrane transporter activity
UZ73_05185	COG4215	(ABC) transporter
UZ73_05190	COG4160	amino acid transport
UZ73_05200	COG0446	pyridine nucleotide-disulphide oxidoreductase
UZ73_05210	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
UZ73_05215	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
UZ73_05220	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
UZ73_05225	COG2251	uridine kinase activity
UZ73_05225	COG0195	Participates in both transcription termination and antitermination
UZ73_05230	COG0779	Required for maturation of 30S ribosomal subunits
UZ73_05235	COG1187	pseudouridine synthase activity
UZ73_05265	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
UZ73_05270	COG1028	Short-chain dehydrogenase reductase Sdr
UZ73_05275	COG3243	poly(R)-hydroxyalkanoic acid synthase
UZ73_05285	COG0564	pseudouridine synthase activity
UZ73_05300	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
UZ73_05300	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
UZ73_05315	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
UZ73_05315	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
UZ73_05330	COG1733	regulation of RNA biosynthetic process
UZ73_05340	COG1199	ATP-dependent helicase activity
UZ73_05345	COG2183	response to ionizing radiation
UZ73_05365	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
UZ73_05370	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
UZ73_05375	COG0508	dehydrogenase complex catalyzes the overall conversion of
UZ73_05380	COG0567	Dehydrogenase, E1 component
UZ73_05390	COG0280	phosphate acetyltransferase
UZ73_05390	COG0281	malic enzyme
UZ73_05395	COG1620	l-lactate permease
UZ73_05400	COG2186	Transcriptional regulator
UZ73_05405	COG0372	Belongs to the citrate synthase family
UZ73_05410	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
UZ73_05415	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
UZ73_05420	COG1053	succinate dehydrogenase
UZ73_05430	COG2009	succinate dehydrogenase
UZ73_05435	COG2188	Transcriptional regulator
UZ73_05440	COG0039	L-malate dehydrogenase activity
UZ73_05450	COG0477	Major facilitator Superfamily
UZ73_05455	COG3829	transcription factor binding
UZ73_05485	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
UZ73_05510	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
UZ73_05515	COG1028	Short-chain dehydrogenase reductase Sdr
UZ73_05530	COG0183	Belongs to the thiolase family
UZ73_05540	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
UZ73_05560	COG1454	alcohol dehydrogenase
UZ73_05565	COG1012	belongs to the aldehyde dehydrogenase family
UZ73_05570	COG3284	Transcriptional regulator
UZ73_05580	COG4172	Belongs to the ABC transporter superfamily
UZ73_05585	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
UZ73_05595	COG0747	negative chemotaxis
UZ73_05605	COG1960	acyl-CoA dehydrogenase activity
UZ73_05610	COG0598	Magnesium transport protein CorA
UZ73_05615	COG2363	Small membrane protein
UZ73_05640	COG0655	NAD(P)H dehydrogenase (quinone) activity
UZ73_05645	COG0435	Glutathione S-transferase
UZ73_05650	COG1304	FMN binding
UZ73_05665	COG4773	Receptor
UZ73_05670	COG0745	RESPONSE REGULATOR receiver
UZ73_05675	COG2205	protein histidine kinase activity
UZ73_05690	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
UZ73_05695	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
UZ73_05700	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
UZ73_05705	COG3842	ATPase activity
UZ73_05710	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
UZ73_05730	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
UZ73_05735	COG4977	sequence-specific DNA binding
UZ73_05745	COG0330	HflC and HflK could
UZ73_05765	COG0037	tRNA processing
UZ73_05770	COG0825	malonyl-CoA metabolic process
UZ73_05780	COG0215	cysteine-tRNA ligase activity
UZ73_05795	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
UZ73_05800	COG1968	undecaprenyl-diphosphatase activity
UZ73_05805	COG1253	flavin adenine dinucleotide binding
UZ73_05825	COG2031	fatty acid transporter
UZ73_05830	COG0154	amidase activity
UZ73_05875	COG0668	transmembrane transport
UZ73_05885	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
UZ73_05895	COG3181	Tripartite tricarboxylate transporter family receptor
UZ73_05905	COG1132	(ABC) transporter
UZ73_05910	COG0363	glucosamine-6-phosphate deaminase activity
UZ73_05915	COG1538	Outer membrane efflux protein
UZ73_05920	COG1136	(ABC) transporter
UZ73_05920	COG0577	efflux transmembrane transporter activity
UZ73_05925	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
UZ73_05935	COG3391	amine dehydrogenase activity
UZ73_05945	COG2850	peptidyl-arginine hydroxylation
UZ73_05950	COG3135	benzoate transporter
UZ73_05955	COG2124	cytochrome p450
UZ73_05960	COG0156	8-amino-7-oxononanoate synthase activity
UZ73_05970	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
UZ73_05985	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
UZ73_05990	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
UZ73_05995	COG1994	Peptidase M50
UZ73_06000	COG0009	L-threonylcarbamoyladenylate synthase
UZ73_06015	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
UZ73_06020	COG3327	negative regulation of DNA-templated transcription, initiation
UZ73_06025	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
UZ73_06055	COG1368	sulfuric ester hydrolase activity
UZ73_06070	COG2323	membrane
UZ73_06075	COG2010	Cytochrome c
UZ73_06080	COG1231	oxidoreductase activity
UZ73_06095	COG0583	DNA-binding transcription factor activity
UZ73_06110	COG2205	protein histidine kinase activity
UZ73_06115	COG0745	RESPONSE REGULATOR receiver
UZ73_06130	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
UZ73_06135	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
UZ73_06155	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
UZ73_06160	COG0248	Ppx GppA phosphatase
UZ73_06170	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
UZ73_06180	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
UZ73_06185	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
UZ73_06190	COG1534	Rna-binding protein
UZ73_06195	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
UZ73_06200	COG2233	PERMEase
UZ73_06225	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
UZ73_06230	COG0505	Belongs to the CarA family
UZ73_06235	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
UZ73_06240	COG3391	amine dehydrogenase activity
UZ73_06260	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
UZ73_06275	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
UZ73_06290	COG1074	ATP-dependent DNA helicase activity
UZ73_06305	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
UZ73_06310	COG4149	molybdate abc transporter
UZ73_06315	COG0725	ABC transporter, periplasmic molybdate-binding protein
UZ73_06320	COG4974	Belongs to the 'phage' integrase family
UZ73_06325	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
UZ73_06330	COG2223	nitrite transmembrane transporter activity
UZ73_06340	COG2910	NAD(P)H-binding
UZ73_06345	COG1733	regulation of RNA biosynthetic process
UZ73_06390	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
UZ73_06395	COG1012	belongs to the aldehyde dehydrogenase family
UZ73_06400	COG0583	DNA-binding transcription factor activity
UZ73_06405	COG0280	phosphate acetyltransferase
UZ73_06405	COG0281	malic enzyme
UZ73_06410	COG3181	Tripartite tricarboxylate transporter family receptor
UZ73_06420	COG0802	atpase or kinase
UZ73_06425	COG0860	N-Acetylmuramoyl-L-alanine amidase
UZ73_06430	COG0586	Pfam SNARE associated Golgi protein
UZ73_06435	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
UZ73_06440	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
UZ73_06445	COG1953	Uracil, thiamine, allantoin
UZ73_06450	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
UZ73_06455	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
UZ73_06465	COG0617	tRNA 3'-terminal CCA addition
UZ73_06470	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
UZ73_06475	COG1573	uracil-dna glycosylase
UZ73_06490	COG2814	Major facilitator Superfamily
UZ73_06500	COG1309	transcriptional regulator
UZ73_06510	COG1024	Enoyl-CoA hydratase
UZ73_06515	COG0752	glycyl-tRNA synthetase alpha subunit
UZ73_06520	COG0751	glycine-tRNA ligase activity
UZ73_06525	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
UZ73_06530	COG0204	Acyl-transferase
UZ73_06545	COG0700	Nucleoside recognition
UZ73_06550	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
UZ73_06555	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
UZ73_06580	COG1126	abc transporter atp-binding protein
UZ73_06585	COG0765	amino acid transport
UZ73_06590	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
UZ73_06600	COG2011	ABC-type metal ion transport system permease component
UZ73_06605	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
UZ73_06620	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
UZ73_06620	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
UZ73_06630	COG0318	PFAM AMP-dependent synthetase and ligase
UZ73_06635	COG1473	amidohydrolase
UZ73_06640	COG1607	acyl-coa hydrolase
UZ73_06645	COG2239	Acts as a magnesium transporter
UZ73_06655	COG0653	protein targeting
UZ73_06660	COG1196	nuclear chromosome segregation
UZ73_06660	COG0741	lytic transglycosylase activity
UZ73_06660	COG0739	heme binding
UZ73_06670	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
UZ73_06685	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
UZ73_06690	COG1181	Belongs to the D-alanine--D-alanine ligase family
UZ73_06695	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
UZ73_06700	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
UZ73_06710	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
UZ73_06715	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
UZ73_06720	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
UZ73_06730	COG3116	cell division
UZ73_06735	COG0275	rRNA processing
UZ73_06740	COG2001	Belongs to the MraZ family
UZ73_06750	COG0633	Ferredoxin
UZ73_06755	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
UZ73_06760	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
UZ73_06765	COG0514	ATP-dependent DNA helicase (RecQ)
UZ73_06775	COG0038	chloride channel
UZ73_06780	COG1294	oxidase, subunit
UZ73_06785	COG1271	oxidase subunit
UZ73_06790	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
UZ73_06800	COG2894	cell division
UZ73_06805	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
UZ73_06825	COG0488	(ABC) transporter
UZ73_06835	COG1215	transferase activity, transferring glycosyl groups
UZ73_06840	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
UZ73_06855	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
UZ73_06865	COG0259	pyridoxamine-phosphate oxidase activity
UZ73_06870	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
UZ73_06875	COG0579	oxidoreductase
UZ73_06885	COG0405	Gamma-glutamyltransferase
UZ73_06895	COG1960	acyl-CoA dehydrogenase activity
UZ73_06900	COG1012	belongs to the aldehyde dehydrogenase family
UZ73_06900	COG2030	dehydratase
UZ73_06905	COG0596	Alpha beta hydrolase
UZ73_06910	COG0009	L-threonylcarbamoyladenylate synthase
UZ73_06915	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
UZ73_06920	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
UZ73_06925	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
UZ73_06935	COG0521	Mo-molybdopterin cofactor biosynthetic process
UZ73_06955	COG0126	phosphoglycerate kinase activity
UZ73_06960	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
UZ73_06965	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
UZ73_06970	COG1385	rRNA (uridine-N3-)-methyltransferase activity
UZ73_06975	COG2732	(Barnase) inhibitor
UZ73_06985	COG0280	phosphate acetyltransferase
UZ73_06985	COG0281	malic enzyme
UZ73_06995	COG0436	Aminotransferase
UZ73_07005	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
UZ73_07020	COG0477	Major facilitator Superfamily
UZ73_07030	COG0154	amidase activity
UZ73_07045	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
UZ73_07060	COG0583	DNA-binding transcription factor activity
UZ73_07075	COG4575	ribosome binding
UZ73_07085	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
UZ73_07090	COG2027	D-alanyl-D-alanine carboxypeptidase
UZ73_07095	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
UZ73_07100	COG0343	queuine tRNA-ribosyltransferase activity
UZ73_07105	COG1862	Preprotein translocase
UZ73_07110	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
UZ73_07115	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
UZ73_07120	COG0024	Methionine aminopeptidase
UZ73_07130	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
UZ73_07135	COG1702	phosphate starvation-inducible protein PhoH
UZ73_07140	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
UZ73_07145	COG4535	Mg2 and Co2 transporter CorC
UZ73_07150	COG0815	Transfers the fatty acyl group on membrane lipoproteins
UZ73_07190	COG2814	Major facilitator Superfamily
UZ73_07225	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
UZ73_07230	COG0697	spore germination
UZ73_07245	COG0678	peroxiredoxin activity
UZ73_07275	COG0315	cyclic pyranopterin monophosphate synthase activity
UZ73_07285	COG0314	molybdopterin synthase activity
UZ73_07290	COG0521	Mo-molybdopterin cofactor biosynthetic process
UZ73_07295	COG0303	'Molybdopterin
UZ73_07305	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
UZ73_07310	COG1910	domain protein
UZ73_07325	COG3383	formate dehydrogenase (NAD+) activity
UZ73_07330	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
UZ73_07370	COG0463	Glycosyl transferase, family 2
UZ73_07375	COG2346	COG2346, Truncated hemoglobins
UZ73_07380	COG1959	2 iron, 2 sulfur cluster binding
UZ73_07385	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
UZ73_07390	COG1858	cytochrome C peroxidase
UZ73_07395	COG0410	ABC transporter
UZ73_07400	COG0411	ABC transporter
UZ73_07410	COG0559	Belongs to the binding-protein-dependent transport system permease family
UZ73_07430	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
UZ73_07430	COG2169	Transcriptional regulator
UZ73_07440	COG0785	Cytochrome C biogenesis protein
UZ73_07445	COG4235	cytochrome complex assembly
UZ73_07450	COG3088	subunit of a heme lyase
UZ73_07455	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
UZ73_07465	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
UZ73_07485	COG4133	protoheme IX ABC transporter activity
UZ73_07495	COG0583	DNA-binding transcription factor activity
UZ73_07500	COG0288	reversible hydration of carbon dioxide
UZ73_07515	COG0488	(ABC) transporter
UZ73_07530	COG0367	asparagine synthase
UZ73_07535	COG1024	Enoyl-CoA hydratase
UZ73_07625	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
UZ73_07655	COG0582	viral genome integration into host DNA
UZ73_07660	COG0012	GTP binding
UZ73_07670	COG0193	aminoacyl-tRNA hydrolase activity
UZ73_07675	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
UZ73_07680	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
UZ73_07695	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
UZ73_07705	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
UZ73_07715	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
UZ73_07725	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
UZ73_07730	COG0179	Fumarylacetoacetate (FAA) hydrolase
UZ73_07740	COG0277	FAD linked oxidase domain protein
UZ73_07750	COG0438	transferase activity, transferring glycosyl groups
UZ73_07760	COG0438	transferase activity, transferring glycosyl groups
UZ73_07775	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
UZ73_07780	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
UZ73_07790	COG3648	Uricase
UZ73_07790	COG3195	allantoin biosynthetic process
UZ73_07800	COG0235	Class ii aldolase
UZ73_07805	COG1942	4-Oxalocrotonate Tautomerase
UZ73_07810	COG2233	PERMEase
UZ73_07820	COG0583	DNA-binding transcription factor activity
UZ73_07825	COG3960	tartronate-semialdehyde synthase activity
UZ73_07830	COG3622	Belongs to the hyi family
UZ73_07835	COG2084	Dehydrogenase
UZ73_07845	COG3193	protein, possibly involved in utilization of glycolate and propanediol
UZ73_07850	COG0469	pyruvate kinase activity
UZ73_07855	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
UZ73_07880	COG3278	Belongs to the heme-copper respiratory oxidase family
UZ73_07885	COG1765	OsmC-like protein
UZ73_07890	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
UZ73_07900	COG0509	glycine decarboxylation via glycine cleavage system
UZ73_07905	COG2081	HI0933 family
UZ73_07910	COG1982	Orn Lys Arg decarboxylase major
UZ73_07915	COG0717	Belongs to the dCTP deaminase family
UZ73_07930	COG0489	protein tyrosine kinase activity
UZ73_07940	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
UZ73_07940	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
UZ73_07945	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
UZ73_07950	COG0583	DNA-binding transcription factor activity
UZ73_07955	COG3257	ureidoglycine aminohydrolase activity
UZ73_07960	COG0590	tRNA wobble adenosine to inosine editing
UZ73_07965	COG3391	amine dehydrogenase activity
UZ73_07975	COG0235	Class ii aldolase
UZ73_07980	COG0477	Major facilitator Superfamily
UZ73_07990	COG3706	GGDEF domain
UZ73_07990	COG0745	RESPONSE REGULATOR receiver
UZ73_07995	COG0387	Pfam Sodium calcium exchanger
UZ73_08000	COG0583	DNA-binding transcription factor activity
UZ73_08025	COG3433	isochorismatase activity
UZ73_08025	COG1535	isochorismatase
UZ73_08045	COG0220	tRNA (guanine-N7-)-methyltransferase activity
UZ73_08060	COG1652	LysM domain
UZ73_08065	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
UZ73_08090	COG3128	pkhd-type hydroxylase
UZ73_08095	COG4774	siderophore transport
UZ73_08100	COG0326	Molecular chaperone. Has ATPase activity
UZ73_08125	COG0583	DNA-binding transcription factor activity
UZ73_08135	COG0154	amidase activity
UZ73_08150	COG0477	Major facilitator Superfamily
UZ73_08160	COG4948	Mandelate Racemase Muconate Lactonizing
UZ73_08170	COG1418	mRNA catabolic process
UZ73_08180	COG2161	toxin-antitoxin pair type II binding
UZ73_08190	COG1671	Belongs to the UPF0178 family
UZ73_08200	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
UZ73_08205	COG0861	Integral membrane protein TerC family
UZ73_08230	COG0395	ABC-type sugar transport system, permease component
UZ73_08245	COG3842	ATPase activity
UZ73_08250	COG1349	DNA-binding transcription factor activity
UZ73_08255	COG3181	Tripartite tricarboxylate transporter family receptor
UZ73_08290	COG1113	amino acid transport
UZ73_08295	COG3844	kynureninase activity
UZ73_08300	COG1522	sequence-specific DNA binding
UZ73_08305	COG1609	Transcriptional regulator
UZ73_08325	COG2186	Transcriptional regulator
UZ73_08330	COG1304	FMN binding
UZ73_08335	COG0277	FAD linked oxidase domain protein
UZ73_08350	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
UZ73_08355	COG4605	iron ion homeostasis
UZ73_08360	COG4604	ABC transporter, ATP-binding protein
UZ73_08365	COG4607	ABC-type enterochelin transport system periplasmic component
UZ73_08370	COG4774	siderophore transport
UZ73_08380	COG0789	Transcriptional regulator
UZ73_08390	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
UZ73_08405	COG1846	Transcriptional regulator
UZ73_08425	COG3685	Protein conserved in bacteria
UZ73_08435	COG0583	DNA-binding transcription factor activity
UZ73_08440	COG2814	Major facilitator Superfamily
UZ73_08445	COG0656	L-ascorbic acid biosynthetic process
UZ73_08450	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
UZ73_08485	COG0628	permease
UZ73_08490	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
UZ73_08505	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
UZ73_08515	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
UZ73_08525	COG0129	dihydroxy-acid dehydratase activity
UZ73_08530	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
UZ73_08535	COG0730	response to heat
UZ73_08540	COG0275	rRNA processing
UZ73_08575	COG1950	PFAM Membrane protein of
UZ73_08580	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
UZ73_08585	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
UZ73_08595	COG1560	Kdo2-lipid A biosynthetic process
UZ73_08600	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
UZ73_08610	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
UZ73_08615	COG0803	Belongs to the bacterial solute-binding protein 9 family
UZ73_08620	COG1108	ABC-type Mn2 Zn2 transport systems permease components
UZ73_08630	COG0735	belongs to the Fur family
UZ73_08635	COG0523	cobalamin synthesis protein
UZ73_08640	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
UZ73_08645	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
UZ73_08650	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
UZ73_08665	COG2096	Adenosyltransferase
UZ73_08680	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
UZ73_08695	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
UZ73_08705	COG1280	lysine exporter protein (LysE YggA)
UZ73_08720	COG5295	Hep Hag repeat protein
UZ73_08735	COG0251	oxidation-reduction process
UZ73_08750	COG1346	cytolysis
UZ73_08755	COG2860	membrane
UZ73_08760	COG2223	nitrite transmembrane transporter activity
UZ73_08770	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
UZ73_08780	COG2918	glutathione biosynthetic process
UZ73_08810	COG1250	3-hydroxyacyl-CoA dehydrogenase
UZ73_08815	COG1804	L-carnitine dehydratase bile acid-inducible protein F
UZ73_08825	COG1024	Enoyl-CoA hydratase
UZ73_08830	COG0067	glutamate synthase
UZ73_08830	COG0069	glutamate synthase activity
UZ73_08830	COG0070	glutamate synthase
UZ73_08845	COG0210	DNA helicase
UZ73_08850	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
UZ73_08855	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
UZ73_08880	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
UZ73_08890	COG3391	amine dehydrogenase activity
UZ73_08905	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
UZ73_08920	COG0765	amino acid transport
UZ73_08925	COG0765	amino acid transport
UZ73_08935	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
UZ73_08940	COG0583	DNA-binding transcription factor activity
UZ73_08950	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
UZ73_08955	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
UZ73_08975	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
UZ73_09010	COG2311	Membrane
UZ73_09020	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
UZ73_09055	COG1253	flavin adenine dinucleotide binding
UZ73_09065	COG0583	DNA-binding transcription factor activity
UZ73_09075	COG2814	Major facilitator Superfamily
UZ73_09080	COG0513	Belongs to the DEAD box helicase family
UZ73_09085	COG2819	hydrolase of the alpha beta superfamily
UZ73_09090	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
UZ73_09095	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
UZ73_09130	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
UZ73_09145	COG0683	leucine binding
UZ73_09160	COG0411	ABC transporter
UZ73_09165	COG0410	ABC transporter
UZ73_09175	COG1021	2,3-dihydroxybenzoate-AMP ligase
UZ73_09180	COG3433	isochorismatase activity
UZ73_09180	COG1535	isochorismatase
UZ73_09185	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
UZ73_09185	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
UZ73_09200	COG1169	isochorismate synthase
UZ73_09205	COG1535	isochorismatase
UZ73_09205	COG3433	isochorismatase activity
UZ73_09210	COG1028	Short-chain dehydrogenase reductase Sdr
UZ73_09220	COG0840	transmembrane signaling receptor activity
UZ73_09230	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
UZ73_09235	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
UZ73_09240	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
UZ73_09245	COG2967	ApaG domain
UZ73_09260	COG0546	phosphoglycolate phosphatase activity
UZ73_09270	COG0512	Glutamine amidotransferase of anthranilate synthase
UZ73_09275	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
UZ73_09280	COG0134	indole-3-glycerol-phosphate synthase activity
UZ73_09365	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
UZ73_09375	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
UZ73_09380	COG1024	Enoyl-CoA hydratase
UZ73_09400	COG0321	lipoyl(octanoyl) transferase activity
UZ73_09405	COG2921	Belongs to the UPF0250 family
UZ73_09415	COG1686	Belongs to the peptidase S11 family
UZ73_09425	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
UZ73_09425	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
UZ73_09430	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
UZ73_09435	COG1210	Utp--glucose-1-phosphate uridylyltransferase
UZ73_09440	COG1278	Cold shock
UZ73_09450	COG0859	PFAM glycosyl transferase family 9
UZ73_09455	COG0583	DNA-binding transcription factor activity
UZ73_09460	COG4336	lyase activity
UZ73_09475	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
UZ73_09490	COG0697	spore germination
UZ73_09495	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
UZ73_09500	COG0242	peptide deformylase activity
UZ73_09505	COG0758	DNA mediated transformation
UZ73_09525	COG3712	iron ion homeostasis
UZ73_09535	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
UZ73_09560	COG0559	Belongs to the binding-protein-dependent transport system permease family
UZ73_09565	COG0411	ABC transporter
UZ73_09580	COG3181	Tripartite tricarboxylate transporter family receptor
UZ73_09585	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
UZ73_09590	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
UZ73_09615	COG0252	asparaginase activity
UZ73_09620	COG0564	pseudouridine synthase activity
UZ73_09640	COG1254	Belongs to the acylphosphatase family
UZ73_09655	COG3093	addiction module antidote protein HigA
UZ73_09675	COG0583	DNA-binding transcription factor activity
UZ73_09705	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
UZ73_09715	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
UZ73_09720	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
UZ73_09735	COG3218	ABC-type transport auxiliary lipoprotein component
UZ73_09735	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
UZ73_09740	COG1127	ABC transporter
UZ73_09745	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
UZ73_09775	COG0583	DNA-binding transcription factor activity
UZ73_09790	COG0154	amidase activity
UZ73_09805	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
UZ73_09820	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
UZ73_09830	COG0513	Belongs to the DEAD box helicase family
UZ73_09835	COG1280	lysine exporter protein (LysE YggA)
UZ73_09840	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
UZ73_09860	COG0583	DNA-binding transcription factor activity
UZ73_09865	COG1335	isochorismatase
UZ73_09870	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
UZ73_09880	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
UZ73_09885	COG1804	L-carnitine dehydratase bile acid-inducible protein F
UZ73_09890	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
UZ73_09895	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
UZ73_09900	COG0066	3-isopropylmalate dehydratase activity
UZ73_09905	COG4774	siderophore transport
UZ73_09910	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
UZ73_09920	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
UZ73_09940	COG0018	arginyl-trna synthetase
UZ73_09950	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
UZ73_09970	COG1960	acyl-CoA dehydrogenase activity
UZ73_09975	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
UZ73_09980	COG0183	Belongs to the thiolase family
UZ73_09985	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
UZ73_10000	COG2922	Belongs to the Smg family
UZ73_10030	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
UZ73_10035	COG0028	Belongs to the TPP enzyme family
UZ73_10055	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
UZ73_10065	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
UZ73_10070	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
UZ73_10080	COG4149	molybdate abc transporter
UZ73_10115	COG0431	NADPH-dependent FMN reductase
UZ73_10120	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
UZ73_10140	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
UZ73_10150	COG1464	Belongs to the NlpA lipoprotein family
UZ73_10175	COG2011	ABC-type metal ion transport system permease component
UZ73_10180	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
UZ73_10185	COG1464	Belongs to the NlpA lipoprotein family
UZ73_10190	COG1464	Belongs to the NlpA lipoprotein family
UZ73_10195	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
UZ73_10200	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
UZ73_10205	COG4774	siderophore transport
UZ73_10210	COG3712	iron ion homeostasis
UZ73_10215	COG1595	DNA-templated transcription, initiation
UZ73_10220	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
UZ73_10235	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
UZ73_10240	COG0444	Belongs to the ABC transporter superfamily
UZ73_10245	COG4608	Belongs to the ABC transporter superfamily
UZ73_10250	COG1595	DNA-templated transcription, initiation
UZ73_10285	COG2207	Transcriptional regulator
UZ73_10295	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
UZ73_10305	COG1028	Short-chain dehydrogenase reductase Sdr
UZ73_10335	COG1028	Short-chain dehydrogenase reductase Sdr
UZ73_10360	COG4638	Rieske (2fe-2S)
UZ73_10370	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
UZ73_10375	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
UZ73_10380	COG0179	Fumarylacetoacetate (FAA) hydrolase
UZ73_10400	COG1846	Transcriptional regulator
UZ73_10455	COG0523	cobalamin synthesis protein
UZ73_10475	COG3842	ATPase activity
UZ73_10485	COG0583	DNA-binding transcription factor activity
UZ73_10490	COG0697	spore germination
UZ73_10500	COG3181	Tripartite tricarboxylate transporter family receptor
UZ73_10515	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
UZ73_10520	COG0508	dehydrogenase complex catalyzes the overall conversion of
UZ73_10520	COG0596	Alpha beta hydrolase
UZ73_10530	COG0318	PFAM AMP-dependent synthetase and ligase
UZ73_10545	COG0559	Belongs to the binding-protein-dependent transport system permease family
UZ73_10555	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
UZ73_10565	COG0583	DNA-binding transcription factor activity
UZ73_10570	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
UZ73_10590	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
UZ73_10600	COG1804	L-carnitine dehydratase bile acid-inducible protein F
UZ73_10610	COG1804	L-carnitine dehydratase bile acid-inducible protein F
UZ73_10620	COG1960	acyl-CoA dehydrogenase activity
UZ73_10630	COG2070	2-Nitropropane dioxygenase
UZ73_10650	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
UZ73_10670	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
UZ73_10675	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
UZ73_10700	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
UZ73_10715	COG1187	pseudouridine synthase activity
UZ73_10725	COG0592	DNA-directed DNA polymerase activity
UZ73_10735	COG0230	Belongs to the bacterial ribosomal protein bL34 family
UZ73_10740	COG0594	ribonuclease P activity
UZ73_10745	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
UZ73_10750	COG0706	membrane insertase activity
UZ73_10755	COG0753	catalase activity
UZ73_10780	COG1335	isochorismatase
UZ73_10785	COG2309	aminopeptidase activity
UZ73_10790	COG0596	Alpha beta hydrolase
UZ73_10810	COG0559	Belongs to the binding-protein-dependent transport system permease family
UZ73_10850	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
UZ73_10895	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
UZ73_10905	COG0688	phosphatidylethanolamine metabolic process
UZ73_10910	COG3706	GGDEF domain
UZ73_10920	COG0436	Aminotransferase
UZ73_10925	COG0445	tRNA wobble uridine modification
UZ73_10935	COG1192	Involved in chromosome partitioning
UZ73_10940	COG1475	DNA binding
UZ73_10965	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
UZ73_10970	COG0051	transcription antitermination factor activity, RNA binding
UZ73_10980	COG4176	ABC-type proline glycine betaine transport system permease component
UZ73_10985	COG4175	Glycine betaine
UZ73_10990	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
UZ73_10995	COG0088	Forms part of the polypeptide exit tunnel
UZ73_11000	COG0089	rRNA binding
UZ73_11005	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
UZ73_11010	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
UZ73_11015	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
UZ73_11020	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
UZ73_11025	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
UZ73_11030	COG0255	Belongs to the universal ribosomal protein uL29 family
UZ73_11035	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
UZ73_11055	COG1116	anion transmembrane transporter activity
UZ73_11070	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
UZ73_11070	COG1648	precorrin-2 dehydrogenase activity
UZ73_11075	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
UZ73_11080	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
UZ73_11085	COG0318	PFAM AMP-dependent synthetase and ligase
UZ73_11110	COG0183	Belongs to the thiolase family
UZ73_11115	COG1960	acyl-CoA dehydrogenase activity
UZ73_11130	COG1538	Outer membrane efflux protein
UZ73_11170	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
UZ73_11175	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
UZ73_11180	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
UZ73_11185	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
UZ73_11190	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
UZ73_11195	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
UZ73_11200	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
UZ73_11205	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
UZ73_11210	COG1841	ribosomal large subunit assembly
UZ73_11215	COG0200	Binds to the 23S rRNA
UZ73_11220	COG0201	protein transport
UZ73_11230	COG0257	Belongs to the bacterial ribosomal protein bL36 family
UZ73_11235	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
UZ73_11240	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
UZ73_11245	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
UZ73_11250	COG0202	RNA polymerase activity
UZ73_11255	COG0203	ribosomal protein L17
UZ73_11260	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
UZ73_11280	COG4232	protein-disulfide reductase activity
UZ73_11285	COG0113	porphobilinogen synthase activity
UZ73_11290	COG0218	Necessary for normal cell division and for the maintenance of normal septation
UZ73_11300	COG1333	cytochrome c biogenesis protein
UZ73_11305	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
UZ73_11310	COG5001	Diguanylate cyclase
UZ73_11310	COG5002	protein histidine kinase activity
UZ73_11325	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
UZ73_11330	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
UZ73_11335	COG0232	Belongs to the dGTPase family. Type 2 subfamily
UZ73_11345	COG2814	Major facilitator Superfamily
UZ73_11350	COG0629	single-stranded DNA binding
UZ73_11360	COG3712	iron ion homeostasis
UZ73_11365	COG1595	DNA-templated transcription, initiation
UZ73_11370	COG1802	Transcriptional regulator
UZ73_11375	COG0179	Fumarylacetoacetate (FAA) hydrolase
UZ73_11380	COG3181	Tripartite tricarboxylate transporter family receptor
UZ73_11385	COG0251	oxidation-reduction process
UZ73_11390	COG2814	Major facilitator Superfamily
UZ73_11405	COG2814	Major facilitator Superfamily
UZ73_11415	COG1802	Transcriptional regulator
UZ73_11425	COG3069	C4-dicarboxylate transmembrane transporter activity
UZ73_11475	COG2423	ornithine cyclodeaminase activity
UZ73_11495	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
UZ73_11500	COG2365	Tyrosine phosphatase family
UZ73_11520	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
UZ73_11520	COG1017	nitric oxide dioxygenase activity
UZ73_11530	COG0625	glutathione transferase activity
UZ73_11560	COG0789	Transcriptional regulator
UZ73_11570	COG2814	Major facilitator Superfamily
UZ73_11600	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
UZ73_11605	COG2986	histidine ammonia-lyase
UZ73_11625	COG1228	amidohydrolase
UZ73_11635	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
UZ73_11655	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
UZ73_11660	COG3568	Endonuclease Exonuclease Phosphatase
UZ73_11680	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
UZ73_11700	COG0109	protoheme IX farnesyltransferase activity
UZ73_11735	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
UZ73_11755	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
UZ73_11765	COG1522	sequence-specific DNA binding
UZ73_11770	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
UZ73_11775	COG1595	DNA-templated transcription, initiation
UZ73_11805	COG4774	siderophore transport
UZ73_11820	COG3284	Transcriptional regulator
UZ73_11830	COG2823	Periplasmic or secreted lipoprotein
UZ73_11850	COG1335	isochorismatase
UZ73_11855	COG1335	isochorismatase
UZ73_11865	COG1028	Short-chain dehydrogenase reductase Sdr
UZ73_11870	COG0477	Major facilitator Superfamily
UZ73_11875	COG0583	DNA-binding transcription factor activity
UZ73_11880	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
UZ73_11895	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
UZ73_11905	COG2226	methyltransferase
UZ73_11910	COG3706	GGDEF domain
UZ73_11915	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
UZ73_11925	COG0656	L-ascorbic acid biosynthetic process
UZ73_11930	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
UZ73_11950	COG3483	tryptophan 2,3-dioxygenase activity
UZ73_11955	COG1522	sequence-specific DNA binding
UZ73_11960	COG1802	Transcriptional regulator
UZ73_11965	COG0129	dihydroxy-acid dehydratase activity
UZ73_11980	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
UZ73_11985	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
UZ73_12005	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
UZ73_12025	COG4150	thiosulfate binding
UZ73_12030	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
UZ73_12035	COG4208	sulfate ABC transporter
UZ73_12040	COG2969	positive regulation of protein catabolic process
UZ73_12045	COG0625	glutathione transferase activity
UZ73_12050	COG2857	Cytochrome c1
UZ73_12055	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
UZ73_12060	COG0723	plastoquinol--plastocyanin reductase activity
UZ73_12065	COG1970	mechanosensitive ion channel activity
UZ73_12075	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
UZ73_12090	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
UZ73_12095	COG0537	adenosine 5'-monophosphoramidase activity
UZ73_12100	COG0140	phosphoribosyl-ATP diphosphatase activity
UZ73_12105	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
UZ73_12110	COG0107	imidazoleglycerol-phosphate synthase activity
UZ73_12115	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
UZ73_12125	COG0131	Imidazoleglycerol-phosphate dehydratase
UZ73_12130	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
UZ73_12135	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
UZ73_12140	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
UZ73_12150	COG0842	Transport permease protein
UZ73_12155	COG1131	(ABC) transporter
UZ73_12170	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
UZ73_12175	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
UZ73_12180	COG1127	ABC transporter
UZ73_12195	COG1250	3-hydroxyacyl-CoA dehydrogenase
UZ73_12195	COG1024	Enoyl-CoA hydratase
UZ73_12200	COG0183	Belongs to the thiolase family
UZ73_12210	COG3501	Rhs element vgr protein
UZ73_12295	COG2885	chlorophyll binding
UZ73_12315	COG0697	spore germination
UZ73_12320	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
UZ73_12325	COG0697	spore germination
UZ73_12330	COG2233	PERMEase
UZ73_12340	COG0156	8-amino-7-oxononanoate synthase activity
UZ73_12375	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
UZ73_12400	COG1215	transferase activity, transferring glycosyl groups
UZ73_12415	COG0166	Belongs to the GPI family
UZ73_12430	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
UZ73_12445	COG4263	nitrous-oxide reductase activity
UZ73_12450	COG0348	domain, Protein
UZ73_12450	COG3901	Regulator of nitric oxide reductase transcription
UZ73_12455	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
UZ73_12460	COG0583	DNA-binding transcription factor activity
UZ73_12475	COG0709	Synthesizes selenophosphate from selenide and ATP
UZ73_12490	COG4771	TonB-dependent receptor
UZ73_12500	COG3181	Tripartite tricarboxylate transporter family receptor
UZ73_12510	COG0235	Class ii aldolase
UZ73_12515	COG1476	TRANSCRIPTIONal
UZ73_12525	COG3276	selenocysteine insertion sequence binding
UZ73_12530	COG1921	L-seryl-tRNASec selenium transferase activity
UZ73_12540	COG2864	formate dehydrogenase
UZ73_12545	COG0437	4 iron, 4 sulfur cluster binding
UZ73_12550	COG3383	formate dehydrogenase (NAD+) activity
UZ73_12550	COG0243	molybdopterin cofactor binding
UZ73_12555	COG3383	formate dehydrogenase (NAD+) activity
UZ73_12555	COG0243	molybdopterin cofactor binding
UZ73_12580	COG1116	anion transmembrane transporter activity
UZ73_12600	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
UZ73_12605	COG0477	Major facilitator Superfamily
UZ73_12620	COG5002	protein histidine kinase activity
UZ73_12640	COG3180	Ammonia monooxygenase
UZ73_12665	COG4773	Receptor
UZ73_12670	COG2264	protein methyltransferase activity
UZ73_12675	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
UZ73_12690	COG0811	peptide transport
UZ73_12720	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
UZ73_12775	COG0582	viral genome integration into host DNA
UZ73_12785	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
UZ73_12795	COG2890	protein-(glutamine-N5) methyltransferase activity
UZ73_12800	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
UZ73_12805	COG0163	prenyltransferase activity
UZ73_12810	COG0037	tRNA processing
UZ73_12825	COG1024	Enoyl-CoA hydratase
UZ73_12835	COG0356	it plays a direct role in the translocation of protons across the membrane
UZ73_12845	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
UZ73_12850	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
UZ73_12855	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
UZ73_12860	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
UZ73_12865	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
UZ73_12870	COG0355	proton-transporting ATP synthase activity, rotational mechanism
UZ73_12905	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
UZ73_12915	COG0438	transferase activity, transferring glycosyl groups
UZ73_12920	COG0463	Glycosyl transferase, family 2
UZ73_12935	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
UZ73_12950	COG3473	Maleate cis-trans isomerase
UZ73_12955	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
UZ73_12985	COG2204	response regulator
UZ73_13000	COG0745	RESPONSE REGULATOR receiver
UZ73_13005	COG4771	TonB-dependent receptor
UZ73_13010	COG2226	methyltransferase
UZ73_13015	COG1040	competence protein
UZ73_13020	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
UZ73_13025	COG3181	Tripartite tricarboxylate transporter family receptor
UZ73_13030	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
UZ73_13035	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
UZ73_13045	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
UZ73_13050	COG0588	phosphoglycerate mutase activity
UZ73_13060	COG0793	Belongs to the peptidase S41A family
UZ73_13065	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
UZ73_13085	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
UZ73_13100	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
UZ73_13105	COG0792	nuclease activity
UZ73_13110	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
UZ73_13120	COG1660	Displays ATPase and GTPase activities
UZ73_13125	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
UZ73_13130	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
UZ73_13140	COG1137	ATPase activity
UZ73_13155	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
UZ73_13170	COG1271	oxidase subunit
UZ73_13175	COG1294	oxidase, subunit
UZ73_13185	COG4988	ABC transporter
UZ73_13190	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
UZ73_13195	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
UZ73_13215	COG1238	metal cluster binding
UZ73_13220	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
UZ73_13225	COG1984	allophanate hydrolase subunit 2
UZ73_13230	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
UZ73_13245	COG0745	RESPONSE REGULATOR receiver
UZ73_13250	COG2226	methyltransferase
UZ73_13265	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
UZ73_13275	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
UZ73_13280	COG1538	Outer membrane efflux protein
UZ73_13285	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
UZ73_13290	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
UZ73_13295	COG0351	phosphomethylpyrimidine kinase
UZ73_13300	COG2022	thiamine diphosphate biosynthetic process
UZ73_13320	COG0598	Magnesium transport protein CorA
UZ73_13340	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
UZ73_13350	COG1595	DNA-templated transcription, initiation
UZ73_13365	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
UZ73_13370	COG4206	TonB-dependent receptor
UZ73_13385	COG0477	Major facilitator Superfamily
UZ73_13395	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
UZ73_13400	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
UZ73_13415	COG0237	dephospho-CoA kinase activity
UZ73_13420	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
UZ73_13445	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
UZ73_13450	COG0494	nUDIX hydrolase
UZ73_13460	COG0142	geranyltranstransferase activity
UZ73_13465	COG0786	glutamate:sodium symporter activity
UZ73_13480	COG3604	Transcriptional regulator
UZ73_13495	COG3245	cytochrome
UZ73_13505	COG3384	dioxygenase
UZ73_13510	COG2259	Doxx family
UZ73_13515	COG0583	DNA-binding transcription factor activity
UZ73_13525	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
UZ73_13530	COG0154	amidase activity
UZ73_13535	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
UZ73_13540	COG1077	Cell shape determining protein MreB Mrl
UZ73_13545	COG1792	Involved in formation and maintenance of cell shape
UZ73_13555	COG0768	penicillin binding
UZ73_13560	COG0772	Belongs to the SEDS family
UZ73_13565	COG1194	a g-specific adenine glycosylase
UZ73_13570	COG2177	Part of the ABC transporter FtsEX involved in
UZ73_13575	COG2884	Cell division ATP-binding protein ftsE
UZ73_13580	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
UZ73_13585	COG4597	amino acid ABC transporter
UZ73_13590	COG0765	amino acid transport
UZ73_13595	COG1126	abc transporter atp-binding protein
UZ73_13610	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
UZ73_13635	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
UZ73_13640	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
UZ73_13645	COG0211	Belongs to the bacterial ribosomal protein bL27 family
UZ73_13650	COG0261	This protein binds to 23S rRNA in the presence of protein L20
UZ73_13655	COG3237	CsbD-like
UZ73_13660	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
UZ73_13675	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
UZ73_13680	COG0352	thiamine-phosphate diphosphorylase activity
UZ73_13695	COG1678	Uncharacterized ACR, COG1678
UZ73_13700	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
UZ73_13710	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
UZ73_13720	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
UZ73_13725	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
UZ73_13740	COG3150	esterase
UZ73_13745	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
UZ73_13750	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
UZ73_13755	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
UZ73_13760	COG0511	ligase activity, forming carbon-carbon bonds
UZ73_13765	COG0439	Biotin carboxylase
UZ73_13770	COG2264	protein methyltransferase activity
UZ73_13785	COG3133	Outer membrane lipoprotein
UZ73_13795	COG0762	integral membrane protein
UZ73_13820	COG4681	YaeQ
UZ73_13825	COG0583	DNA-binding transcription factor activity
UZ73_13835	COG1028	Short-chain dehydrogenase reductase Sdr
UZ73_13845	COG0596	Alpha beta hydrolase
UZ73_13845	COG2945	thiolester hydrolase activity
UZ73_13850	COG2233	PERMEase
UZ73_13855	COG0402	S-adenosylhomocysteine deaminase activity
UZ73_13865	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
UZ73_13870	COG4566	intracellular signal transduction
UZ73_13900	COG3028	Belongs to the UPF0307 family
UZ73_13905	COG0312	modulator of DNA gyrase
UZ73_13910	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
UZ73_13915	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
UZ73_13920	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
UZ73_13925	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
UZ73_13935	COG0316	Belongs to the HesB IscA family
UZ73_13940	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
UZ73_13945	COG0739	heme binding
UZ73_13950	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
UZ73_13955	COG1881	PFAM PEBP family protein
UZ73_13960	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
UZ73_13965	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
UZ73_13970	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
UZ73_13970	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
UZ73_13990	COG0642	Histidine kinase
UZ73_13995	COG0745	RESPONSE REGULATOR receiver
UZ73_14000	COG0431	NADPH-dependent FMN reductase
UZ73_14005	COG1393	Belongs to the ArsC family
UZ73_14045	COG0583	DNA-binding transcription factor activity
UZ73_14050	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
UZ73_14065	COG1454	alcohol dehydrogenase
UZ73_14070	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
UZ73_14075	COG0583	DNA-binding transcription factor activity
UZ73_14095	COG1902	pentaerythritol trinitrate reductase activity
UZ73_14120	COG4804	nuclease activity
UZ73_14125	COG2003	Belongs to the UPF0758 family
UZ73_14135	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
UZ73_14185	COG1192	Involved in chromosome partitioning
UZ73_14200	COG4959	Type IV secretory pathway protease TraF
UZ73_14215	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
UZ73_14220	COG0583	DNA-binding transcription factor activity
UZ73_14240	COG4962	Type ii secretion system protein e
UZ73_14245	COG3838	Conjugal transfer protein Trbc
UZ73_14255	COG3451	type IV secretory pathway VirB4
UZ73_14270	COG3846	protein secretion by the type IV secretion system
UZ73_14295	COG1024	Enoyl-CoA hydratase
UZ73_14305	COG0604	alcohol dehydrogenase
UZ73_14340	COG1877	trehalose-phosphatase activity
UZ73_14345	COG1028	Short-chain dehydrogenase reductase Sdr
UZ73_14360	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
UZ73_14375	COG2204	response regulator
UZ73_14380	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
UZ73_14415	COG1301	dicarboxylic acid transport
UZ73_14420	COG4191	Histidine kinase
UZ73_14425	COG2204	response regulator
UZ73_14450	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
UZ73_14470	COG1388	LysM domain
UZ73_14470	COG0741	lytic transglycosylase activity
UZ73_14475	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
UZ73_14480	COG2226	methyltransferase
UZ73_14485	COG0328	RNA-DNA hybrid ribonuclease activity
UZ73_14490	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
UZ73_14495	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
UZ73_14500	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
UZ73_14510	COG3181	Tripartite tricarboxylate transporter family receptor
UZ73_14515	COG0402	S-adenosylhomocysteine deaminase activity
UZ73_14520	COG0583	DNA-binding transcription factor activity
UZ73_14525	COG2031	fatty acid transporter
UZ73_14530	COG4206	TonB-dependent receptor
UZ73_14545	COG1120	ATPase activity
UZ73_14560	COG0596	Alpha beta hydrolase
UZ73_14565	COG2309	aminopeptidase activity
UZ73_14570	COG1335	isochorismatase
UZ73_14595	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
UZ73_14625	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
UZ73_14635	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
UZ73_14640	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
UZ73_14640	COG3608	succinylglutamate desuccinylase aspartoacylase
UZ73_14645	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
UZ73_14645	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
UZ73_14655	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
UZ73_14665	COG2188	Transcriptional regulator
UZ73_14670	COG1234	tRNA 3'-trailer cleavage
UZ73_14690	COG3181	Tripartite tricarboxylate transporter family receptor
UZ73_14705	COG3706	GGDEF domain
UZ73_14730	COG0411	ABC transporter
UZ73_14735	COG0410	ABC transporter
UZ73_14745	COG1529	Aldehyde oxidase and xanthine dehydrogenase
UZ73_14745	COG2010	Cytochrome c
UZ73_14750	COG2080	2 iron, 2 sulfur cluster binding
UZ73_14755	COG1529	Aldehyde oxidase and xanthine dehydrogenase
UZ73_14755	COG2010	Cytochrome c
UZ73_14760	COG0596	Alpha beta hydrolase
UZ73_14765	COG2309	aminopeptidase activity
UZ73_14770	COG1335	isochorismatase
UZ73_14785	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
UZ73_14815	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
UZ73_14820	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
UZ73_14825	COG0742	ribosomal rna small subunit methyltransferase
UZ73_14850	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
UZ73_14855	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
UZ73_14865	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
UZ73_14875	COG1414	Transcriptional regulator
UZ73_14890	COG0284	orotidine-5'-phosphate decarboxylase activity
UZ73_14895	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
UZ73_14900	COG0459	protein refolding
UZ73_14905	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
UZ73_14915	COG1595	DNA-templated transcription, initiation
UZ73_14920	COG3712	iron ion homeostasis
UZ73_14930	COG0154	amidase activity
UZ73_14935	COG3706	GGDEF domain
UZ73_14940	COG1741	Belongs to the pirin family
UZ73_14945	COG0583	DNA-binding transcription factor activity
UZ73_14960	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
UZ73_14975	COG0175	sulfate reduction
UZ73_14980	COG0697	spore germination
UZ73_14995	COG3634	alkyl hydroperoxide reductase activity
UZ73_15000	COG0583	DNA-binding transcription factor activity
UZ73_15005	COG0427	acetyl-CoA hydrolase
UZ73_15025	COG1129	ABC transporter
UZ73_15045	COG0534	Mate efflux family protein
UZ73_15060	COG0596	Alpha beta hydrolase
UZ73_15075	COG0823	Involved in the tonB-independent uptake of proteins
UZ73_15090	COG0811	peptide transport
UZ73_15095	COG0824	Thioesterase
UZ73_15100	COG0442	prolyl-tRNA aminoacylation
UZ73_15105	COG0494	nUDIX hydrolase
UZ73_15120	COG2084	Dehydrogenase
UZ73_15125	COG1840	ABC-type Fe3 transport system, periplasmic component
UZ73_15130	COG3842	ATPase activity
UZ73_15135	COG1177	transmembrane transport
UZ73_15170	COG4654	Cytochrome c, class I
UZ73_15175	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
UZ73_15230	COG2186	Transcriptional regulator
UZ73_15235	COG0277	FAD linked oxidase domain protein
UZ73_15240	COG0277	FAD linked oxidase domain protein
UZ73_15245	COG0247	lactate metabolic process
UZ73_15280	COG1283	sodium-dependent phosphate transmembrane transporter activity
UZ73_15295	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
UZ73_15305	COG0697	spore germination
UZ73_15325	COG3094	Invasion gene expression up-regulator, SirB
UZ73_15335	COG0640	Transcriptional regulator
UZ73_15360	COG0659	secondary active sulfate transmembrane transporter activity
UZ73_15365	COG1262	PFAM Formylglycine-generating sulfatase enzyme
UZ73_15375	COG2314	TM2 domain
UZ73_15380	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
UZ73_15385	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
UZ73_15390	COG0791	NLP P60 protein
UZ73_15410	COG1360	Flagellar Motor Protein
UZ73_15420	COG0835	chemotaxis
UZ73_15425	COG0840	transmembrane signaling receptor activity
UZ73_15430	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
UZ73_15440	COG0745	RESPONSE REGULATOR receiver
UZ73_15445	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
UZ73_15455	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
UZ73_15480	COG1815	bacterial-type flagellum-dependent cell motility
UZ73_15485	COG1558	bacterial-type flagellum-dependent cell motility
UZ73_15490	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
UZ73_15495	COG1749	Flagellar hook protein flgE
UZ73_15505	COG4786	Flagellar basal body rod
UZ73_15515	COG1706	bacterial-type flagellum-dependent cell motility
UZ73_15525	COG1256	bacterial-type flagellum assembly
UZ73_15530	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
UZ73_15555	COG2176	DNA-directed DNA polymerase activity
UZ73_15565	COG1987	bacterial-type flagellum assembly
UZ73_15580	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
UZ73_15605	COG1157	protein secretion by the type III secretion system
UZ73_15615	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
UZ73_15620	COG1766	The M ring may be actively involved in energy transduction
UZ73_15625	COG1677	Flagellar hook-basal body complex protein FliE
UZ73_15630	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
UZ73_15655	COG1334	flagellar protein FlaG
UZ73_15660	COG1191	sigma factor activity
UZ73_15715	COG1262	PFAM Formylglycine-generating sulfatase enzyme
UZ73_15735	COG2733	membrane
UZ73_15740	COG0840	transmembrane signaling receptor activity
UZ73_15745	COG0840	transmembrane signaling receptor activity
UZ73_15770	COG2610	gluconate transmembrane transporter activity
UZ73_15785	COG4521	taurine ABC transporter
UZ73_15790	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
UZ73_15795	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
UZ73_15800	COG1028	Short-chain dehydrogenase reductase Sdr
UZ73_15805	COG0583	DNA-binding transcription factor activity
UZ73_15835	COG2824	Alkylphosphonate utilization operon protein PhnA
UZ73_15850	COG4771	TonB-dependent receptor
UZ73_15855	COG1858	cytochrome C peroxidase
UZ73_15865	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
UZ73_15895	COG1113	amino acid transport
UZ73_15915	COG0583	DNA-binding transcription factor activity
UZ73_15920	COG3755	Protein conserved in bacteria
UZ73_15925	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
UZ73_15965	COG0446	pyridine nucleotide-disulphide oxidoreductase
UZ73_15990	COG1278	Cold shock
UZ73_15995	COG0642	Histidine kinase
UZ73_16000	COG0745	RESPONSE REGULATOR receiver
UZ73_16005	COG3278	Belongs to the heme-copper respiratory oxidase family
UZ73_16015	COG2863	cytochrome
UZ73_16020	COG3258	Cytochrome c
UZ73_16050	COG0025	NhaP-type Na H and K H
UZ73_16065	COG1289	transmembrane transporter activity
UZ73_16070	COG2252	PERMEase
UZ73_16075	COG0560	Phosphoserine phosphatase
UZ73_16090	COG1999	signal sequence binding
UZ73_16100	COG0069	glutamate synthase activity
UZ73_16110	COG1846	Transcriptional regulator
UZ73_16120	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
UZ73_16160	COG1028	Short-chain dehydrogenase reductase Sdr
UZ73_16170	COG3264	Mechanosensitive ion channel
UZ73_16170	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
UZ73_16175	COG3264	Mechanosensitive ion channel
UZ73_16175	COG1196	nuclear chromosome segregation
UZ73_16180	COG0477	Major facilitator Superfamily
UZ73_16195	COG1396	sequence-specific DNA binding
UZ73_16200	COG3437	response regulator, receiver
UZ73_16205	COG2205	protein histidine kinase activity
UZ73_16205	COG2198	Histidine kinase
UZ73_16205	COG0784	Response regulator, receiver
UZ73_16210	COG2239	Acts as a magnesium transporter
UZ73_16220	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
UZ73_16225	COG1490	D-aminoacyl-tRNA deacylase activity
UZ73_16240	COG0456	acetyltransferase
UZ73_16250	COG0501	Belongs to the peptidase M48B family
UZ73_16255	COG2814	Major facilitator Superfamily
UZ73_16265	COG4115	mRNA cleavage
UZ73_16270	COG2161	toxin-antitoxin pair type II binding
UZ73_16390	COG3772	lysozyme
UZ73_16440	COG3706	GGDEF domain
UZ73_16455	COG1522	sequence-specific DNA binding
UZ73_16460	COG0626	cystathionine gamma-synthase activity
UZ73_16470	COG0494	nUDIX hydrolase
UZ73_16475	COG2832	Protein of unknown function (DUF454)
UZ73_16485	COG0137	argininosuccinate synthase activity
UZ73_16490	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
UZ73_16495	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
UZ73_16515	COG1609	Transcriptional regulator
UZ73_16520	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
UZ73_16530	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
UZ73_16535	COG2205	protein histidine kinase activity
UZ73_16540	COG0745	RESPONSE REGULATOR receiver
UZ73_16545	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
UZ73_16555	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
UZ73_16560	COG0268	Binds directly to 16S ribosomal RNA
UZ73_16565	COG0728	peptidoglycan biosynthetic process
UZ73_16575	COG0563	adenylate kinase activity
UZ73_16580	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
UZ73_16585	COG2835	tetraacyldisaccharide 4'-kinase activity
UZ73_16590	COG1663	tetraacyldisaccharide 4'-kinase activity
UZ73_16600	COG0811	peptide transport
UZ73_16605	COG1570	exodeoxyribonuclease VII activity
UZ73_16610	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
UZ73_16620	COG0183	Belongs to the thiolase family
UZ73_16630	COG1278	Cold shock
UZ73_16635	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
UZ73_16640	COG0542	response to heat
UZ73_16645	COG2995	paraquat-inducible protein a
UZ73_16650	COG3008	intermembrane lipid transfer
UZ73_16650	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
UZ73_16670	COG0559	Belongs to the binding-protein-dependent transport system permease family
UZ73_16680	COG0411	ABC transporter
UZ73_16700	COG0300	oxidoreductase activity
UZ73_16710	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
UZ73_16715	COG0756	dUTP diphosphatase activity
UZ73_16725	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
UZ73_16730	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
UZ73_16735	COG0196	riboflavin kinase activity
UZ73_16740	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
UZ73_16745	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
UZ73_16745	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
UZ73_16755	COG0210	DNA helicase
UZ73_16810	COG0488	(ABC) transporter
UZ73_16815	COG2890	protein-(glutamine-N5) methyltransferase activity
UZ73_16820	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
UZ73_16825	COG2171	N-acyltransferase activity
UZ73_16835	COG2207	Transcriptional regulator
UZ73_16845	COG0471	metal ion transport
UZ73_16845	COG3273	potassium ion transport
UZ73_16895	COG0789	Transcriptional regulator
UZ73_16915	COG1804	L-carnitine dehydratase bile acid-inducible protein F
UZ73_16920	COG0544	peptidyl-prolyl cis-trans isomerase activity
UZ73_16925	COG0740	serine-type endopeptidase activity
UZ73_16930	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
UZ73_16935	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
UZ73_16955	COG0556	nucleotide-excision repair
UZ73_16960	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
UZ73_16965	COG1959	2 iron, 2 sulfur cluster binding
UZ73_16970	COG1104	cysteine desulfurase activity
UZ73_16975	COG0822	iron-sulfur transferase activity
UZ73_16980	COG0316	Belongs to the HesB IscA family
UZ73_16995	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
UZ73_17000	COG4221	oxidoreductase activity
UZ73_17005	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
UZ73_17015	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
UZ73_17020	COG0697	spore germination
UZ73_17025	COG0385	Bile acid
UZ73_17035	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
UZ73_17050	COG1136	(ABC) transporter
UZ73_17055	COG0084	hydrolase, TatD family'
UZ73_17065	COG0596	Alpha beta hydrolase
UZ73_17070	COG0613	PHP domain protein
UZ73_17080	COG0047	phosphoribosylformylglycinamidine synthase activity
UZ73_17080	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
UZ73_17105	COG0519	Catalyzes the synthesis of GMP from XMP
UZ73_17105	COG0518	GMP synthase (glutamine-hydrolyzing) activity
UZ73_17110	COG1595	DNA-templated transcription, initiation
UZ73_17130	COG3971	2-oxopent-4-enoate hydratase activity
UZ73_17135	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
UZ73_17150	COG0583	DNA-binding transcription factor activity
UZ73_17165	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
UZ73_17175	COG1960	acyl-CoA dehydrogenase activity
UZ73_17180	COG0523	cobalamin synthesis protein
UZ73_17185	COG1469	GTP cyclohydrolase I activity
UZ73_17200	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
UZ73_17205	COG0735	belongs to the Fur family
UZ73_17210	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
UZ73_17240	COG0745	RESPONSE REGULATOR receiver
UZ73_17245	COG2207	Transcriptional regulator
UZ73_17260	COG0494	nUDIX hydrolase
UZ73_17265	COG0583	DNA-binding transcription factor activity
UZ73_17270	COG1289	transmembrane transporter activity
UZ73_17290	COG1942	4-Oxalocrotonate Tautomerase
UZ73_17305	COG3162	membrane
UZ73_17310	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
UZ73_17320	COG2070	2-Nitropropane dioxygenase
UZ73_17355	COG1309	transcriptional regulator
UZ73_17380	COG2816	NAD+ diphosphatase activity
UZ73_17385	COG0625	glutathione transferase activity
UZ73_17390	COG0740	serine-type endopeptidase activity
UZ73_17445	COG1804	L-carnitine dehydratase bile acid-inducible protein F
UZ73_17455	COG1960	acyl-CoA dehydrogenase activity
UZ73_17485	COG0640	Transcriptional regulator
UZ73_17510	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
UZ73_17535	COG3485	protocatechuate 3,4-dioxygenase
UZ73_17545	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
UZ73_17550	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
UZ73_17560	COG3135	benzoate transporter
UZ73_17565	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
UZ73_17570	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
UZ73_17580	COG4555	ABC transporter
UZ73_17590	COG2197	response regulator
UZ73_17620	COG1846	Transcriptional regulator
UZ73_17625	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
UZ73_17630	COG2271	Major facilitator Superfamily
UZ73_17640	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
UZ73_17650	COG0697	spore germination
UZ73_17675	COG3842	ATPase activity
UZ73_17690	COG2205	protein histidine kinase activity
UZ73_17705	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
UZ73_17710	COG0667	Aldo Keto reductase
UZ73_17735	COG2135	peptidase activity
UZ73_17770	COG1272	protein, Hemolysin III
UZ73_17795	COG0765	amino acid transport
UZ73_17800	COG0765	amino acid transport
UZ73_17805	COG1126	abc transporter atp-binding protein
UZ73_17855	COG2871	sodium ion transport
UZ73_17885	COG2814	Major facilitator Superfamily
UZ73_17890	COG1280	lysine exporter protein (LysE YggA)
UZ73_17910	COG0402	S-adenosylhomocysteine deaminase activity
UZ73_17935	COG0330	HflC and HflK could
UZ73_17940	COG1585	Membrane protein implicated in regulation of membrane protease activity
UZ73_17945	COG2226	methyltransferase
UZ73_17955	COG3042	response to heat
UZ73_17965	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
UZ73_17980	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
UZ73_17985	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
UZ73_17990	COG0189	ligase activity
UZ73_18000	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
UZ73_18005	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
UZ73_18045	COG0291	Belongs to the bacterial ribosomal protein bL35 family
UZ73_18050	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
UZ73_18055	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
UZ73_18060	COG0072	phenylalanine-tRNA ligase activity
UZ73_18060	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
UZ73_18065	COG0776	regulation of translation
UZ73_18075	COG2833	Protein of unknown function (DUF455)
UZ73_18090	COG5265	(ABC) transporter
UZ73_18095	COG1959	2 iron, 2 sulfur cluster binding
UZ73_18100	COG0719	Fe-S assembly protein
UZ73_18105	COG0396	ATPase activity
UZ73_18110	COG0719	Fe-S assembly protein
UZ73_18120	COG0822	iron-sulfur transferase activity
UZ73_18125	COG2151	metal-sulfur cluster biosynthetic enzyme
UZ73_18145	COG1538	Outer membrane efflux protein
UZ73_18180	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
UZ73_18185	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
UZ73_18190	COG1181	Belongs to the D-alanine--D-alanine ligase family
UZ73_18210	COG0747	negative chemotaxis
UZ73_18215	COG0601	transmembrane transport
UZ73_18220	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
UZ73_18225	COG4172	Belongs to the ABC transporter superfamily
UZ73_18235	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
UZ73_18280	COG0604	alcohol dehydrogenase
UZ73_18285	COG2207	Transcriptional regulator
UZ73_18290	COG3048	D-serine ammonia-lyase activity
UZ73_18295	COG3258	Cytochrome c
UZ73_18310	COG3949	Membrane
UZ73_18325	COG1262	PFAM Formylglycine-generating sulfatase enzyme
UZ73_18340	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
UZ73_18345	COG0569	domain protein
UZ73_18350	COG1902	pentaerythritol trinitrate reductase activity
UZ73_18360	COG1610	YqeY-like protein
UZ73_18365	COG0587	DNA-directed DNA polymerase activity
UZ73_18400	COG3181	Tripartite tricarboxylate transporter family receptor
UZ73_18405	COG0583	DNA-binding transcription factor activity
UZ73_18410	COG1686	Belongs to the peptidase S11 family
UZ73_18425	COG1360	Flagellar Motor Protein
UZ73_18435	COG1028	Short-chain dehydrogenase reductase Sdr
UZ73_18445	COG4221	oxidoreductase activity
UZ73_18450	COG0307	riboflavin synthase, alpha
UZ73_18495	COG2233	PERMEase
UZ73_18500	COG0071	Belongs to the small heat shock protein (HSP20) family
UZ73_18545	COG2816	NAD+ diphosphatase activity
UZ73_18550	COG1561	YicC-like family, N-terminal region
UZ73_18565	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
UZ73_18570	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
UZ73_18575	COG0635	Involved in the biosynthesis of porphyrin-containing compound
UZ73_18585	COG2153	protein acetylation
UZ73_18605	COG3842	ATPase activity
UZ73_18610	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
UZ73_18615	COG1840	ABC-type Fe3 transport system, periplasmic component
UZ73_18630	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
UZ73_18640	COG0783	Belongs to the Dps family
UZ73_18650	COG3842	ATPase activity
UZ73_18655	COG0395	ABC-type sugar transport system, permease component
UZ73_18660	COG1175	transmembrane transport
UZ73_18665	COG1653	transport
UZ73_18680	COG0559	Belongs to the binding-protein-dependent transport system permease family
UZ73_18690	COG0411	ABC transporter
UZ73_18700	COG0625	glutathione transferase activity
UZ73_18710	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
UZ73_18715	COG1028	Short-chain dehydrogenase reductase Sdr
UZ73_18725	COG0114	fumarate hydratase activity
UZ73_18730	COG2133	pyrroloquinoline quinone binding
UZ73_18735	COG2226	methyltransferase
UZ73_18740	COG0589	response to stress
UZ73_18745	COG4654	Cytochrome c, class I
UZ73_18765	COG1012	belongs to the aldehyde dehydrogenase family
UZ73_18770	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
UZ73_18775	COG2807	transmembrane transport
UZ73_18785	COG0583	DNA-binding transcription factor activity
UZ73_18815	COG0583	DNA-binding transcription factor activity
UZ73_18820	COG4974	Belongs to the 'phage' integrase family
UZ73_18830	COG2132	Multicopper oxidase
UZ73_18995	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
UZ73_19040	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
UZ73_19055	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
UZ73_19060	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
UZ73_19065	COG0049	tRNA binding
UZ73_19070	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
UZ73_19100	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
UZ73_19105	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
UZ73_19110	COG0085	RNA polymerase activity
UZ73_19115	COG0222	ribosome binding
UZ73_19120	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
UZ73_19130	COG0081	regulation of translation
UZ73_19135	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
UZ73_19180	COG3316	Transposase and inactivated derivatives
UZ73_19200	COG3173	Aminoglycoside phosphotransferase