locus-tag	class	description
CLH39_00045	COG3391	amine dehydrogenase activity
CLH39_00065	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CLH39_00070	COG0028	Belongs to the TPP enzyme family
CLH39_00090	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CLH39_00100	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CLH39_00105	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
CLH39_00115	COG4149	molybdate abc transporter
CLH39_00150	COG0431	NADPH-dependent FMN reductase
CLH39_00155	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CLH39_00170	COG1464	Belongs to the NlpA lipoprotein family
CLH39_00195	COG2011	ABC-type metal ion transport system permease component
CLH39_00200	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CLH39_00205	COG1464	Belongs to the NlpA lipoprotein family
CLH39_00210	COG1464	Belongs to the NlpA lipoprotein family
CLH39_00225	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CLH39_00230	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CLH39_00240	COG0601	transmembrane transport
CLH39_00245	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CLH39_00250	COG0444	Belongs to the ABC transporter superfamily
CLH39_00255	COG4608	Belongs to the ABC transporter superfamily
CLH39_00260	COG1595	DNA-templated transcription, initiation
CLH39_00290	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CLH39_00305	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CLH39_00315	COG1028	Short-chain dehydrogenase reductase Sdr
CLH39_00375	COG4638	Rieske (2fe-2S)
CLH39_00385	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
CLH39_00390	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CLH39_00395	COG0179	Fumarylacetoacetate (FAA) hydrolase
CLH39_00415	COG1846	Transcriptional regulator
CLH39_00470	COG0523	cobalamin synthesis protein
CLH39_00475	COG0697	spore germination
CLH39_00485	COG3181	Tripartite tricarboxylate transporter family receptor
CLH39_00500	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CLH39_00505	COG0508	dehydrogenase complex catalyzes the overall conversion of
CLH39_00505	COG0596	Alpha beta hydrolase
CLH39_00515	COG0318	PFAM AMP-dependent synthetase and ligase
CLH39_00530	COG0559	Belongs to the binding-protein-dependent transport system permease family
CLH39_00540	COG0436	Aminotransferase
CLH39_00550	COG2271	Major facilitator Superfamily
CLH39_00555	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
CLH39_00560	COG1802	Transcriptional regulator
CLH39_00565	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
CLH39_00575	COG0583	DNA-binding transcription factor activity
CLH39_00580	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
CLH39_00600	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CLH39_00605	COG2186	Transcriptional regulator
CLH39_00620	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CLH39_00640	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CLH39_00645	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
CLH39_00670	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CLH39_00685	COG1187	pseudouridine synthase activity
CLH39_00695	COG0592	DNA-directed DNA polymerase activity
CLH39_00700	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CLH39_00705	COG0230	Belongs to the bacterial ribosomal protein bL34 family
CLH39_00710	COG0594	ribonuclease P activity
CLH39_00715	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
CLH39_00720	COG0706	membrane insertase activity
CLH39_00725	COG0753	catalase activity
CLH39_00750	COG1335	isochorismatase
CLH39_00755	COG2309	aminopeptidase activity
CLH39_00760	COG0596	Alpha beta hydrolase
CLH39_00780	COG0559	Belongs to the binding-protein-dependent transport system permease family
CLH39_00820	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CLH39_00875	COG3645	SOS response
CLH39_00915	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CLH39_00925	COG0688	phosphatidylethanolamine metabolic process
CLH39_00935	COG3706	GGDEF domain
CLH39_00940	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
CLH39_00945	COG0436	Aminotransferase
CLH39_00950	COG0445	tRNA wobble uridine modification
CLH39_00955	COG0357	Ribosomal RNA small subunit methyltransferase G
CLH39_00960	COG1192	Involved in chromosome partitioning
CLH39_00965	COG1475	DNA binding
CLH39_00990	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CLH39_01015	COG0081	regulation of translation
CLH39_01020	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
CLH39_01025	COG0222	ribosome binding
CLH39_01030	COG0085	RNA polymerase activity
CLH39_01035	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CLH39_01040	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
CLH39_01070	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CLH39_01075	COG0049	tRNA binding
CLH39_01080	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CLH39_01085	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CLH39_01090	COG0051	transcription antitermination factor activity, RNA binding
CLH39_01095	COG4176	ABC-type proline glycine betaine transport system permease component
CLH39_01100	COG4175	Glycine betaine
CLH39_01105	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CLH39_01110	COG0088	Forms part of the polypeptide exit tunnel
CLH39_01115	COG0089	rRNA binding
CLH39_01120	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CLH39_01125	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CLH39_01130	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
CLH39_01135	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CLH39_01140	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CLH39_01145	COG0255	Belongs to the universal ribosomal protein uL29 family
CLH39_01150	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CLH39_01165	COG1960	acyl-CoA dehydrogenase activity
CLH39_01170	COG1116	anion transmembrane transporter activity
CLH39_01185	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CLH39_01185	COG1648	precorrin-2 dehydrogenase activity
CLH39_01190	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CLH39_01195	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
CLH39_01200	COG0318	PFAM AMP-dependent synthetase and ligase
CLH39_01215	COG2067	long-chain fatty acid transport protein
CLH39_01225	COG0183	Belongs to the thiolase family
CLH39_01230	COG1960	acyl-CoA dehydrogenase activity
CLH39_01245	COG1538	Outer membrane efflux protein
CLH39_01285	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
CLH39_01290	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
CLH39_01295	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
CLH39_01300	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CLH39_01305	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
CLH39_01310	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
CLH39_01315	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
CLH39_01320	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CLH39_01325	COG1841	ribosomal large subunit assembly
CLH39_01330	COG0200	Binds to the 23S rRNA
CLH39_01335	COG0201	protein transport
CLH39_01345	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CLH39_01350	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CLH39_01355	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
CLH39_01360	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CLH39_01365	COG0202	RNA polymerase activity
CLH39_01370	COG0203	ribosomal protein L17
CLH39_01375	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CLH39_01395	COG4232	protein-disulfide reductase activity
CLH39_01400	COG0113	porphobilinogen synthase activity
CLH39_01405	COG0218	Necessary for normal cell division and for the maintenance of normal septation
CLH39_01415	COG1333	cytochrome c biogenesis protein
CLH39_01420	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CLH39_01425	COG5001	Diguanylate cyclase
CLH39_01425	COG5002	protein histidine kinase activity
CLH39_01445	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CLH39_01450	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CLH39_01455	COG0232	Belongs to the dGTPase family. Type 2 subfamily
CLH39_01465	COG2814	Major facilitator Superfamily
CLH39_01480	COG3712	iron ion homeostasis
CLH39_01485	COG1595	DNA-templated transcription, initiation
CLH39_01490	COG1802	Transcriptional regulator
CLH39_01495	COG0179	Fumarylacetoacetate (FAA) hydrolase
CLH39_01500	COG3181	Tripartite tricarboxylate transporter family receptor
CLH39_01505	COG0251	oxidation-reduction process
CLH39_01510	COG2814	Major facilitator Superfamily
CLH39_01525	COG2814	Major facilitator Superfamily
CLH39_01530	COG1309	transcriptional regulator
CLH39_01535	COG1802	Transcriptional regulator
CLH39_01545	COG3069	C4-dicarboxylate transmembrane transporter activity
CLH39_01595	COG2423	ornithine cyclodeaminase activity
CLH39_01615	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
CLH39_01620	COG2365	Tyrosine phosphatase family
CLH39_01650	COG0625	glutathione transferase activity
CLH39_01680	COG0789	Transcriptional regulator
CLH39_01690	COG0583	DNA-binding transcription factor activity
CLH39_01715	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
CLH39_01720	COG2986	histidine ammonia-lyase
CLH39_01740	COG1228	amidohydrolase
CLH39_01750	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CLH39_01775	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CLH39_01780	COG3568	Endonuclease Exonuclease Phosphatase
CLH39_01800	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CLH39_01820	COG0109	protoheme IX farnesyltransferase activity
CLH39_01855	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CLH39_01875	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CLH39_01885	COG1522	sequence-specific DNA binding
CLH39_01900	COG0438	transferase activity, transferring glycosyl groups
CLH39_01935	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
CLH39_01960	COG1595	DNA-templated transcription, initiation
CLH39_02000	COG0583	DNA-binding transcription factor activity
CLH39_02005	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CLH39_02010	COG3284	Transcriptional regulator
CLH39_02020	COG2823	Periplasmic or secreted lipoprotein
CLH39_02040	COG1335	isochorismatase
CLH39_02045	COG1335	isochorismatase
CLH39_02060	COG1028	Short-chain dehydrogenase reductase Sdr
CLH39_02065	COG0477	Major facilitator Superfamily
CLH39_02070	COG0583	DNA-binding transcription factor activity
CLH39_02075	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
CLH39_02090	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CLH39_02100	COG2226	methyltransferase
CLH39_02105	COG3706	GGDEF domain
CLH39_02110	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
CLH39_02120	COG0656	L-ascorbic acid biosynthetic process
CLH39_02125	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
CLH39_02145	COG3483	tryptophan 2,3-dioxygenase activity
CLH39_02150	COG1522	sequence-specific DNA binding
CLH39_02155	COG1802	Transcriptional regulator
CLH39_02160	COG0129	dihydroxy-acid dehydratase activity
CLH39_02165	COG2084	Dehydrogenase
CLH39_02175	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CLH39_02180	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
CLH39_02200	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CLH39_02215	COG4150	thiosulfate binding
CLH39_02220	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
CLH39_02225	COG4208	sulfate ABC transporter
CLH39_02230	COG2969	positive regulation of protein catabolic process
CLH39_02235	COG0625	glutathione transferase activity
CLH39_02240	COG2857	Cytochrome c1
CLH39_02245	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
CLH39_02250	COG0723	plastoquinol--plastocyanin reductase activity
CLH39_02255	COG1970	mechanosensitive ion channel activity
CLH39_02265	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CLH39_02275	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CLH39_02280	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CLH39_02285	COG0537	adenosine 5'-monophosphoramidase activity
CLH39_02290	COG0140	phosphoribosyl-ATP diphosphatase activity
CLH39_02300	COG0107	imidazoleglycerol-phosphate synthase activity
CLH39_02305	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
CLH39_02315	COG0131	Imidazoleglycerol-phosphate dehydratase
CLH39_02320	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
CLH39_02330	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CLH39_02340	COG0842	Transport permease protein
CLH39_02345	COG1131	(ABC) transporter
CLH39_02360	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
CLH39_02365	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CLH39_02370	COG1127	ABC transporter
CLH39_02385	COG1250	3-hydroxyacyl-CoA dehydrogenase
CLH39_02385	COG1024	Enoyl-CoA hydratase
CLH39_02390	COG0183	Belongs to the thiolase family
CLH39_02485	COG2885	chlorophyll binding
CLH39_02505	COG0697	spore germination
CLH39_02510	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CLH39_02515	COG0697	spore germination
CLH39_02520	COG2233	PERMEase
CLH39_02525	COG0604	alcohol dehydrogenase
CLH39_02525	COG1028	Short-chain dehydrogenase reductase Sdr
CLH39_02525	COG3321	synthase
CLH39_02530	COG0156	8-amino-7-oxononanoate synthase activity
CLH39_02565	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
CLH39_02570	COG0438	transferase activity, transferring glycosyl groups
CLH39_02600	COG1215	transferase activity, transferring glycosyl groups
CLH39_02625	COG0166	Belongs to the GPI family
CLH39_02640	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
CLH39_02655	COG4263	nitrous-oxide reductase activity
CLH39_02665	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
CLH39_02670	COG0709	Synthesizes selenophosphate from selenide and ATP
CLH39_02695	COG3276	selenocysteine insertion sequence binding
CLH39_02700	COG1921	L-seryl-tRNASec selenium transferase activity
CLH39_02710	COG2864	formate dehydrogenase
CLH39_02715	COG0437	4 iron, 4 sulfur cluster binding
CLH39_02720	COG3383	formate dehydrogenase (NAD+) activity
CLH39_02720	COG0243	molybdopterin cofactor binding
CLH39_02725	COG0243	molybdopterin cofactor binding
CLH39_02725	COG3383	formate dehydrogenase (NAD+) activity
CLH39_02750	COG1116	anion transmembrane transporter activity
CLH39_02770	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CLH39_02775	COG0477	Major facilitator Superfamily
CLH39_02790	COG5002	protein histidine kinase activity
CLH39_02810	COG3180	Ammonia monooxygenase
CLH39_02835	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CLH39_02845	COG1595	DNA-templated transcription, initiation
CLH39_02860	COG2264	protein methyltransferase activity
CLH39_02865	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CLH39_02875	COG0811	peptide transport
CLH39_02905	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CLH39_02950	COG3550	peptidyl-serine autophosphorylation
CLH39_02970	COG2890	protein-(glutamine-N5) methyltransferase activity
CLH39_02975	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
CLH39_02980	COG0163	prenyltransferase activity
CLH39_02985	COG0037	tRNA processing
CLH39_03000	COG1024	Enoyl-CoA hydratase
CLH39_03010	COG0356	it plays a direct role in the translocation of protons across the membrane
CLH39_03025	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CLH39_03030	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CLH39_03035	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CLH39_03045	COG0355	proton-transporting ATP synthase activity, rotational mechanism
CLH39_03060	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
CLH39_03075	COG3473	Maleate cis-trans isomerase
CLH39_03080	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CLH39_03095	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CLH39_03115	COG2204	response regulator
CLH39_03125	COG2205	protein histidine kinase activity
CLH39_03130	COG0745	RESPONSE REGULATOR receiver
CLH39_03135	COG4771	TonB-dependent receptor
CLH39_03140	COG2226	methyltransferase
CLH39_03145	COG1040	competence protein
CLH39_03150	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
CLH39_03155	COG3181	Tripartite tricarboxylate transporter family receptor
CLH39_03160	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CLH39_03165	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
CLH39_03175	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CLH39_03180	COG0588	phosphoglycerate mutase activity
CLH39_03190	COG0793	Belongs to the peptidase S41A family
CLH39_03195	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CLH39_03215	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CLH39_03230	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
CLH39_03235	COG0792	nuclease activity
CLH39_03240	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
CLH39_03245	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
CLH39_03250	COG1660	Displays ATPase and GTPase activities
CLH39_03255	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
CLH39_03260	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CLH39_03270	COG1137	ATPase activity
CLH39_03285	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
CLH39_03300	COG1271	oxidase subunit
CLH39_03305	COG1294	oxidase, subunit
CLH39_03315	COG4988	ABC transporter
CLH39_03320	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
CLH39_03360	COG1238	metal cluster binding
CLH39_03365	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CLH39_03370	COG1984	allophanate hydrolase subunit 2
CLH39_03375	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
CLH39_03390	COG0745	RESPONSE REGULATOR receiver
CLH39_03395	COG2226	methyltransferase
CLH39_03410	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
CLH39_03420	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
CLH39_03425	COG1538	Outer membrane efflux protein
CLH39_03430	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
CLH39_03435	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CLH39_03440	COG0351	phosphomethylpyrimidine kinase
CLH39_03445	COG2022	thiamine diphosphate biosynthetic process
CLH39_03460	COG0598	Magnesium transport protein CorA
CLH39_03480	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
CLH39_03495	COG1595	DNA-templated transcription, initiation
CLH39_03510	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CLH39_03515	COG4206	TonB-dependent receptor
CLH39_03530	COG0477	Major facilitator Superfamily
CLH39_03540	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
CLH39_03545	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
CLH39_03560	COG0237	dephospho-CoA kinase activity
CLH39_03565	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
CLH39_03590	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
CLH39_03595	COG0494	nUDIX hydrolase
CLH39_03605	COG0142	geranyltranstransferase activity
CLH39_03610	COG0786	glutamate:sodium symporter activity
CLH39_03625	COG3604	Transcriptional regulator
CLH39_03650	COG3384	dioxygenase
CLH39_03655	COG2259	Doxx family
CLH39_03660	COG0583	DNA-binding transcription factor activity
CLH39_03665	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CLH39_03670	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CLH39_03675	COG0154	amidase activity
CLH39_03680	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CLH39_03685	COG1077	Cell shape determining protein MreB Mrl
CLH39_03690	COG1792	Involved in formation and maintenance of cell shape
CLH39_03700	COG0768	penicillin binding
CLH39_03705	COG0772	Belongs to the SEDS family
CLH39_03715	COG2177	Part of the ABC transporter FtsEX involved in
CLH39_03720	COG2884	Cell division ATP-binding protein ftsE
CLH39_03730	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CLH39_03735	COG4597	amino acid ABC transporter
CLH39_03740	COG0765	amino acid transport
CLH39_03745	COG1126	abc transporter atp-binding protein
CLH39_03765	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
CLH39_03790	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
CLH39_03795	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CLH39_03800	COG0211	Belongs to the bacterial ribosomal protein bL27 family
CLH39_03805	COG0261	This protein binds to 23S rRNA in the presence of protein L20
CLH39_03810	COG3237	CsbD-like
CLH39_03820	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
CLH39_03835	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CLH39_03840	COG0352	thiamine-phosphate diphosphorylase activity
CLH39_03855	COG1678	Uncharacterized ACR, COG1678
CLH39_03870	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
CLH39_03880	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CLH39_03885	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CLH39_03900	COG3150	esterase
CLH39_03905	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CLH39_03915	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
CLH39_03920	COG0511	ligase activity, forming carbon-carbon bonds
CLH39_03925	COG0439	Biotin carboxylase
CLH39_03940	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CLH39_03945	COG3133	Outer membrane lipoprotein
CLH39_03950	COG2169	Transcriptional regulator
CLH39_03950	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CLH39_03955	COG0762	integral membrane protein
CLH39_03985	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CLH39_03990	COG4566	intracellular signal transduction
CLH39_03995	COG2205	protein histidine kinase activity
CLH39_03995	COG0745	RESPONSE REGULATOR receiver
CLH39_03995	COG4191	Histidine kinase
CLH39_04025	COG3028	Belongs to the UPF0307 family
CLH39_04030	COG0312	modulator of DNA gyrase
CLH39_04035	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
CLH39_04040	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CLH39_04045	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
CLH39_04050	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
CLH39_04060	COG0316	Belongs to the HesB IscA family
CLH39_04065	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
CLH39_04070	COG0739	heme binding
CLH39_04075	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CLH39_04080	COG1881	PFAM PEBP family protein
CLH39_04085	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CLH39_04090	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CLH39_04095	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CLH39_04095	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CLH39_04135	COG0642	Histidine kinase
CLH39_04140	COG0745	RESPONSE REGULATOR receiver
CLH39_04145	COG0431	NADPH-dependent FMN reductase
CLH39_04150	COG1393	Belongs to the ArsC family
CLH39_04165	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CLH39_04175	COG1280	lysine exporter protein (LysE YggA)
CLH39_04200	COG2015	COG2015, Alkyl sulfatase and related hydrolases
CLH39_04220	COG1024	Enoyl-CoA hydratase
CLH39_04230	COG0604	alcohol dehydrogenase
CLH39_04265	COG1877	trehalose-phosphatase activity
CLH39_04270	COG1028	Short-chain dehydrogenase reductase Sdr
CLH39_04285	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
CLH39_04310	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CLH39_04335	COG1054	Belongs to the UPF0176 family
CLH39_04345	COG1301	dicarboxylic acid transport
CLH39_04350	COG4191	Histidine kinase
CLH39_04355	COG2204	response regulator
CLH39_04380	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
CLH39_04400	COG1388	LysM domain
CLH39_04400	COG0741	lytic transglycosylase activity
CLH39_04405	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CLH39_04410	COG2226	methyltransferase
CLH39_04415	COG0328	RNA-DNA hybrid ribonuclease activity
CLH39_04420	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CLH39_04425	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CLH39_04440	COG3181	Tripartite tricarboxylate transporter family receptor
CLH39_04445	COG0402	S-adenosylhomocysteine deaminase activity
CLH39_04450	COG0583	DNA-binding transcription factor activity
CLH39_04455	COG2031	fatty acid transporter
CLH39_04460	COG4206	TonB-dependent receptor
CLH39_04470	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CLH39_04475	COG1120	ATPase activity
CLH39_04490	COG0596	Alpha beta hydrolase
CLH39_04495	COG2309	aminopeptidase activity
CLH39_04500	COG1335	isochorismatase
CLH39_04525	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
CLH39_04550	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
CLH39_04555	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CLH39_04565	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CLH39_04570	COG3608	succinylglutamate desuccinylase aspartoacylase
CLH39_04570	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
CLH39_04575	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CLH39_04575	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
CLH39_04585	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CLH39_04595	COG2188	Transcriptional regulator
CLH39_04600	COG1234	tRNA 3'-trailer cleavage
CLH39_04610	COG3181	Tripartite tricarboxylate transporter family receptor
CLH39_04625	COG3706	GGDEF domain
CLH39_04650	COG0411	ABC transporter
CLH39_04655	COG0410	ABC transporter
CLH39_04665	COG2010	Cytochrome c
CLH39_04665	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CLH39_04670	COG2080	2 iron, 2 sulfur cluster binding
CLH39_04675	COG2010	Cytochrome c
CLH39_04675	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CLH39_04680	COG0596	Alpha beta hydrolase
CLH39_04685	COG2309	aminopeptidase activity
CLH39_04690	COG1335	isochorismatase
CLH39_04715	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
CLH39_04745	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
CLH39_04750	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
CLH39_04755	COG0742	ribosomal rna small subunit methyltransferase
CLH39_04780	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
CLH39_04785	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CLH39_04790	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
CLH39_04795	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
CLH39_04805	COG1414	Transcriptional regulator
CLH39_04820	COG0284	orotidine-5'-phosphate decarboxylase activity
CLH39_04825	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
CLH39_04835	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CLH39_04850	COG0154	amidase activity
CLH39_04855	COG3706	GGDEF domain
CLH39_04865	COG1741	Belongs to the pirin family
CLH39_04870	COG0583	DNA-binding transcription factor activity
CLH39_04885	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CLH39_04890	COG2895	sulfate adenylyltransferase (ATP) activity
CLH39_04900	COG0697	spore germination
CLH39_04915	COG3634	alkyl hydroperoxide reductase activity
CLH39_04920	COG0583	DNA-binding transcription factor activity
CLH39_04925	COG0427	acetyl-CoA hydrolase
CLH39_04945	COG3845	ABC transporter
CLH39_04950	COG4603	Belongs to the binding-protein-dependent transport system permease family
CLH39_04955	COG1079	Belongs to the binding-protein-dependent transport system permease family
CLH39_04980	COG0596	Alpha beta hydrolase
CLH39_04995	COG0823	Involved in the tonB-independent uptake of proteins
CLH39_05010	COG0811	peptide transport
CLH39_05015	COG0824	Thioesterase
CLH39_05020	COG0442	prolyl-tRNA aminoacylation
CLH39_05025	COG0494	nUDIX hydrolase
CLH39_05040	COG2084	Dehydrogenase
CLH39_05045	COG1840	ABC-type Fe3 transport system, periplasmic component
CLH39_05050	COG3842	ATPase activity
CLH39_05055	COG1177	transmembrane transport
CLH39_05095	COG4654	Cytochrome c, class I
CLH39_05100	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CLH39_05165	COG0415	Belongs to the DNA photolyase family
CLH39_05175	COG0418	dihydroorotase activity
CLH39_05185	COG2255	four-way junction helicase activity
CLH39_05195	COG0632	four-way junction helicase activity
CLH39_05200	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
CLH39_05210	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
CLH39_05220	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CLH39_05245	COG0429	hydrolase of the alpha beta-hydrolase fold
CLH39_05265	COG0513	Belongs to the DEAD box helicase family
CLH39_05285	COG1414	Transcriptional regulator
CLH39_05305	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
CLH39_05310	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
CLH39_05325	COG1846	Transcriptional regulator
CLH39_05330	COG1027	Aspartate ammonia-lyase
CLH39_05345	COG0517	IMP dehydrogenase activity
CLH39_05345	COG0516	GMP reductase activity
CLH39_05410	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
CLH39_05455	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
CLH39_05475	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CLH39_05480	COG3278	Belongs to the heme-copper respiratory oxidase family
CLH39_05495	COG0697	spore germination
CLH39_05525	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CLH39_05540	COG0789	Transcriptional regulator
CLH39_05550	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
CLH39_05555	COG0505	Belongs to the CarA family
CLH39_05570	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CLH39_05585	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CLH39_05595	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
CLH39_05600	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
CLH39_05610	COG3243	poly(R)-hydroxyalkanoic acid synthase
CLH39_05615	COG1538	Outer membrane efflux protein
CLH39_05620	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CLH39_05625	COG0842	Transport permease protein
CLH39_05625	COG1129	ABC transporter
CLH39_05640	COG1028	Short-chain dehydrogenase reductase Sdr
CLH39_05675	COG2814	Major facilitator Superfamily
CLH39_05680	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CLH39_05685	COG0154	amidase activity
CLH39_05705	COG2197	response regulator
CLH39_05710	COG2205	protein histidine kinase activity
CLH39_05710	COG0784	Response regulator, receiver
CLH39_05715	COG0784	Response regulator, receiver
CLH39_05715	COG2205	protein histidine kinase activity
CLH39_05725	COG3121	Chaperone
CLH39_05745	COG2814	Major facilitator Superfamily
CLH39_05755	COG4569	acetaldehyde dehydrogenase (acetylating) activity
CLH39_05760	COG3971	2-oxopent-4-enoate hydratase activity
CLH39_05775	COG0446	pyridine nucleotide-disulphide oxidoreductase
CLH39_05790	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
CLH39_05795	COG4638	Rieske (2fe-2S)
CLH39_05800	COG0583	DNA-binding transcription factor activity
CLH39_05810	COG0513	Belongs to the DEAD box helicase family
CLH39_05815	COG1414	Transcriptional regulator
CLH39_05850	COG1454	alcohol dehydrogenase
CLH39_05865	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
CLH39_05870	COG2819	hydrolase of the alpha beta superfamily
CLH39_05875	COG3058	Necessary for formate dehydrogenase activity
CLH39_05880	COG2864	formate dehydrogenase
CLH39_05885	COG0437	4 iron, 4 sulfur cluster binding
CLH39_05890	COG3383	formate dehydrogenase (NAD+) activity
CLH39_05890	COG0243	molybdopterin cofactor binding
CLH39_05900	COG2814	Major facilitator Superfamily
CLH39_05920	COG2814	Major facilitator Superfamily
CLH39_05945	COG1538	Outer membrane efflux protein
CLH39_05970	COG0812	UDP-N-acetylmuramate dehydrogenase activity
CLH39_05980	COG1301	dicarboxylic acid transport
CLH39_05985	COG0477	Major facilitator Superfamily
CLH39_05995	COG2267	carboxylic ester hydrolase activity
CLH39_06010	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
CLH39_06015	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CLH39_06020	COG0735	belongs to the Fur family
CLH39_06025	COG0497	DNA recombination
CLH39_06035	COG1420	regulation of RNA biosynthetic process
CLH39_06040	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
CLH39_06045	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CLH39_06050	COG0443	Heat shock 70 kDa protein
CLH39_06055	COG0484	heat shock protein binding
CLH39_06060	COG0612	Peptidase, M16
CLH39_06120	COG4964	Belongs to the GSP D family
CLH39_06160	COG2204	response regulator
CLH39_06180	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CLH39_06205	COG1960	acyl-CoA dehydrogenase activity
CLH39_06210	COG2272	Belongs to the type-B carboxylesterase lipase family
CLH39_06230	COG0477	Major facilitator Superfamily
CLH39_06250	COG0492	ferredoxin-NADP+ reductase activity
CLH39_06255	COG1674	ftsk spoiiie
CLH39_06260	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
CLH39_06265	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CLH39_06270	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CLH39_06290	COG1028	Short-chain dehydrogenase reductase Sdr
CLH39_06295	COG3022	response to hydroperoxide
CLH39_06300	COG1289	transmembrane transporter activity
CLH39_06305	COG0028	Belongs to the TPP enzyme family
CLH39_06310	COG0440	acetolactate synthase activity
CLH39_06315	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
CLH39_06320	COG1183	phosphatidylcholine synthase activity
CLH39_06325	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
CLH39_06330	COG1185	polyribonucleotide nucleotidyltransferase activity
CLH39_06350	COG0604	alcohol dehydrogenase
CLH39_06355	COG0149	triose-phosphate isomerase activity
CLH39_06370	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
CLH39_06375	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CLH39_06380	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CLH39_06385	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CLH39_06390	COG0649	NAD binding
CLH39_06405	COG1034	ATP synthesis coupled electron transport
CLH39_06410	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
CLH39_06415	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CLH39_06425	COG0713	ATP synthesis coupled electron transport
CLH39_06440	COG1007	ATP synthesis coupled electron transport
CLH39_06450	COG2070	2-Nitropropane dioxygenase
CLH39_06455	COG0560	Phosphoserine phosphatase
CLH39_06460	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CLH39_06465	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
CLH39_06470	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
CLH39_06485	COG1214	PFAM Peptidase M22, glycoprotease
CLH39_06490	COG1573	uracil-dna glycosylase
CLH39_06500	COG1196	nuclear chromosome segregation
CLH39_06510	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CLH39_06515	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CLH39_06525	COG2917	probably involved in intracellular septation
CLH39_06530	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CLH39_06555	COG3047	cAMP biosynthetic process
CLH39_06560	COG1129	ABC transporter
CLH39_06565	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CLH39_06570	COG2878	Part of a membrane complex involved in electron transport
CLH39_06580	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
CLH39_06585	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
CLH39_06595	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CLH39_06600	COG0133	tryptophan synthase activity
CLH39_06605	COG0159	tryptophan synthase activity
CLH39_06610	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
CLH39_06615	COG1530	ribonuclease E activity
CLH39_06620	COG0564	pseudouridine synthase activity
CLH39_06625	COG0546	phosphoglycolate phosphatase activity
CLH39_06630	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
CLH39_06635	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
CLH39_06640	COG3023	N-Acetylmuramoyl-L-alanine amidase
CLH39_06650	COG0424	maF-like protein
CLH39_06655	COG1399	metal-binding, possibly nucleic acid-binding protein
CLH39_06660	COG0333	Belongs to the bacterial ribosomal protein bL32 family
CLH39_06670	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CLH39_06675	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
CLH39_06680	COG1028	Short-chain dehydrogenase reductase Sdr
CLH39_06685	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CLH39_06690	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CLH39_06715	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CLH39_06730	COG0571	ribonuclease III activity
CLH39_06735	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CLH39_06740	COG1381	Involved in DNA repair and RecF pathway recombination
CLH39_06755	COG1045	serine acetyltransferase
CLH39_06770	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CLH39_06780	COG0583	DNA-binding transcription factor activity
CLH39_06790	COG0583	DNA-binding transcription factor activity
CLH39_06800	COG0791	NLP P60 protein
CLH39_06810	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CLH39_06845	COG0504	CTP synthase activity
CLH39_06855	COG2877	3-deoxy-8-phosphooctulonate synthase activity
CLH39_06870	COG2814	Major facilitator Superfamily
CLH39_06880	COG0148	phosphopyruvate hydratase activity
CLH39_06885	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
CLH39_06895	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
CLH39_06910	COG1981	membrane
CLH39_06915	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
CLH39_06920	COG1466	dna polymerase III delta subunit
CLH39_06930	COG0495	leucyl-tRNA aminoacylation
CLH39_06935	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CLH39_06940	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CLH39_06945	COG2814	Major facilitator Superfamily
CLH39_06950	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CLH39_06960	COG4176	ABC-type proline glycine betaine transport system permease component
CLH39_06965	COG4175	Glycine betaine
CLH39_06970	COG0534	Mate efflux family protein
CLH39_06985	COG2271	Major facilitator Superfamily
CLH39_06995	COG0477	Major facilitator Superfamily
CLH39_07000	COG1737	Transcriptional regulator
CLH39_07005	COG2003	Belongs to the UPF0758 family
CLH39_07010	COG1047	Peptidyl-prolyl cis-trans
CLH39_07015	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
CLH39_07020	COG0625	glutathione transferase activity
CLH39_07025	COG2084	Dehydrogenase
CLH39_07035	COG0023	Translation Initiation Factor
CLH39_07055	COG0424	maF-like protein
CLH39_07060	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
CLH39_07065	COG0799	negative regulation of ribosome biogenesis
CLH39_07070	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CLH39_07080	COG0151	Belongs to the GarS family
CLH39_07085	COG0217	transcriptional regulatory protein
CLH39_07090	COG0433	COG0433 Predicted ATPase
CLH39_07100	COG0473	3-isopropylmalate dehydrogenase activity
CLH39_07115	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
CLH39_07120	COG0308	aminopeptidase N
CLH39_07135	COG0312	modulator of DNA gyrase
CLH39_07145	COG1846	Transcriptional regulator
CLH39_07150	COG0456	acetyltransferase
CLH39_07160	COG0662	Cupin 2, conserved barrel domain protein
CLH39_07165	COG5285	phytanoyl-CoA dioxygenase
CLH39_07180	COG1126	abc transporter atp-binding protein
CLH39_07185	COG0765	amino acid transport
CLH39_07190	COG0765	amino acid transport
CLH39_07195	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CLH39_07200	COG1966	Carbon starvation protein
CLH39_07205	COG2879	small protein
CLH39_07210	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
CLH39_07215	COG0277	FAD linked oxidase domain protein
CLH39_07220	COG0482	sulfurtransferase activity
CLH39_07225	COG0730	response to heat
CLH39_07230	COG0657	acetylesterase activity
CLH39_07240	COG0625	glutathione transferase activity
CLH39_07250	COG3909	cytochrome
CLH39_07255	COG0004	ammonium transporteR
CLH39_07260	COG0347	Belongs to the P(II) protein family
CLH39_07265	COG1846	Transcriptional regulator
CLH39_07270	COG2175	clavaminate synthase activity
CLH39_07275	COG2271	Major facilitator Superfamily
CLH39_07290	COG2321	neutral zinc metallopeptidase
CLH39_07295	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
CLH39_07310	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CLH39_07315	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
CLH39_07330	COG2119	membrane
CLH39_07335	COG0840	transmembrane signaling receptor activity
CLH39_07350	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
CLH39_07355	COG2046	Belongs to the sulfate adenylyltransferase family
CLH39_07365	COG0784	Response regulator, receiver
CLH39_07365	COG2198	Histidine kinase
CLH39_07365	COG2205	protein histidine kinase activity
CLH39_07375	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CLH39_07395	COG1280	lysine exporter protein (LysE YggA)
CLH39_07400	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
CLH39_07410	COG0625	glutathione transferase activity
CLH39_07460	COG0488	(ABC) transporter
CLH39_07470	COG1309	transcriptional regulator
CLH39_07475	COG0251	oxidation-reduction process
CLH39_07485	COG0436	Aminotransferase
CLH39_07495	COG4335	DNA alkylation repair
CLH39_07500	COG1408	metallophosphoesterase
CLH39_07505	COG0753	catalase activity
CLH39_07520	COG4771	TonB-dependent receptor
CLH39_07530	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
CLH39_07540	COG0583	DNA-binding transcription factor activity
CLH39_07550	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CLH39_07565	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
CLH39_07575	COG0287	Prephenate dehydrogenase
CLH39_07580	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CLH39_07585	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
CLH39_07605	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
CLH39_07610	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
CLH39_07615	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CLH39_07630	COG2951	lytic endotransglycosylase activity
CLH39_07650	COG1960	acyl-CoA dehydrogenase activity
CLH39_07655	COG0450	alkyl hydroperoxide reductase
CLH39_07675	COG0335	large ribosomal subunit rRNA binding
CLH39_07685	COG1162	GTPase activity
CLH39_07690	COG0501	Belongs to the peptidase M48B family
CLH39_07695	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
CLH39_07700	COG3396	Phenylacetate-CoA oxygenase
CLH39_07705	COG3460	Phenylacetate-CoA oxygenase
CLH39_07710	COG3396	Phenylacetate-CoA oxygenase
CLH39_07715	COG2151	metal-sulfur cluster biosynthetic enzyme
CLH39_07720	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CLH39_07725	COG1012	belongs to the aldehyde dehydrogenase family
CLH39_07730	COG1024	Enoyl-CoA hydratase
CLH39_07735	COG2050	protein possibly involved in aromatic compounds catabolism
CLH39_07745	COG0736	holo-[acyl-carrier-protein] synthase activity
CLH39_07750	COG1472	Belongs to the glycosyl hydrolase 3 family
CLH39_07770	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
CLH39_07770	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
CLH39_07775	COG2224	Isocitrate lyase
CLH39_07780	COG2217	Heavy metal translocating P-type atpase
CLH39_07790	COG3278	Belongs to the heme-copper respiratory oxidase family
CLH39_07810	COG0348	domain, Protein
CLH39_07825	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CLH39_07830	COG0542	response to heat
CLH39_07835	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
CLH39_07840	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
CLH39_07870	COG0601	transmembrane transport
CLH39_07875	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CLH39_07885	COG4638	Rieske (2fe-2S)
CLH39_07900	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CLH39_07905	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
CLH39_07930	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CLH39_07965	COG2351	hydroxyisourate hydrolase activity
CLH39_07980	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CLH39_07985	COG0425	Belongs to the sulfur carrier protein TusA family
CLH39_07990	COG0228	four-way junction DNA binding
CLH39_08000	COG0336	Belongs to the RNA methyltransferase TrmD family
CLH39_08005	COG0697	spore germination
CLH39_08010	COG0583	DNA-binding transcription factor activity
CLH39_08015	COG0525	valine-tRNA ligase activity
CLH39_08020	COG0105	UTP biosynthetic process
CLH39_08025	COG0820	rRNA (adenine-C2-)-methyltransferase activity
CLH39_08040	COG0124	histidyl-tRNA synthetase
CLH39_08045	COG2976	Protein conserved in bacteria
CLH39_08050	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CLH39_08055	COG1160	GTP binding
CLH39_08065	COG1923	regulation of RNA biosynthetic process
CLH39_08070	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CLH39_08075	COG0330	HflC and HflK could
CLH39_08080	COG0330	HflC and HflK could
CLH39_08090	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CLH39_08095	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
CLH39_08100	COG0828	Belongs to the bacterial ribosomal protein bS21 family
CLH39_08115	COG2205	protein histidine kinase activity
CLH39_08120	COG0745	RESPONSE REGULATOR receiver
CLH39_08130	COG0402	S-adenosylhomocysteine deaminase activity
CLH39_08140	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CLH39_08165	COG3135	benzoate transporter
CLH39_08170	COG2207	Transcriptional regulator
CLH39_08175	COG2807	transmembrane transport
CLH39_08180	COG2814	Major facilitator Superfamily
CLH39_08185	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CLH39_08195	COG1741	Belongs to the pirin family
CLH39_08205	COG0625	glutathione transferase activity
CLH39_08210	COG3530	Putative quorum-sensing-regulated virulence factor
CLH39_08215	COG0412	Dienelactone hydrolase
CLH39_08235	COG1840	ABC-type Fe3 transport system, periplasmic component
CLH39_08240	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CLH39_08250	COG3842	ATPase activity
CLH39_08255	COG0583	DNA-binding transcription factor activity
CLH39_08290	COG2375	cellular response to nickel ion
CLH39_08310	COG1850	ribulose-bisphosphate carboxylase activity
CLH39_08325	COG1126	abc transporter atp-binding protein
CLH39_08330	COG0765	amino acid transport
CLH39_08335	COG0765	amino acid transport
CLH39_08370	COG0557	exoribonuclease II activity
CLH39_08375	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CLH39_08380	COG0626	cystathionine gamma-synthase activity
CLH39_08385	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CLH39_08390	COG2010	Cytochrome c
CLH39_08400	COG1648	precorrin-2 dehydrogenase activity
CLH39_08400	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CLH39_08410	COG0535	radical SAM domain protein
CLH39_08425	COG1522	sequence-specific DNA binding
CLH39_08440	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CLH39_08440	COG1648	precorrin-2 dehydrogenase activity
CLH39_08580	COG1802	Transcriptional regulator
CLH39_08580	COG4626	Terminase
CLH39_08635	COG0740	serine-type endopeptidase activity
CLH39_08740	COG2135	peptidase activity
CLH39_08760	COG1278	Cold shock
CLH39_08775	COG4106	trans-aconitate 2-methyltransferase activity
CLH39_08780	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
CLH39_08785	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
CLH39_08790	COG4208	sulfate ABC transporter
CLH39_08795	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
CLH39_08820	COG0642	Histidine kinase
CLH39_08825	COG3158	transport of potassium into the cell
CLH39_08840	COG2212	antiporter activity
CLH39_08850	COG0651	ATP synthesis coupled electron transport
CLH39_08855	COG1006	Multisubunit Na H antiporter MnhC subunit
CLH39_08860	COG2111	Na H antiporter
CLH39_08860	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CLH39_08865	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CLH39_08870	COG2070	2-Nitropropane dioxygenase
CLH39_08885	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CLH39_08900	COG0540	Belongs to the ATCase OTCase family
CLH39_08915	COG3162	membrane
CLH39_08920	COG1024	Enoyl-CoA hydratase
CLH39_08925	COG0318	PFAM AMP-dependent synthetase and ligase
CLH39_08940	COG0477	Major facilitator Superfamily
CLH39_08955	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CLH39_08960	COG2137	regulation of response to DNA damage stimulus
CLH39_08965	COG0583	DNA-binding transcription factor activity
CLH39_08970	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
CLH39_08980	COG0045	succinate-CoA ligase (ADP-forming) activity
CLH39_08985	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
CLH39_08990	COG0861	Integral membrane protein TerC family
CLH39_08995	COG0181	hydroxymethylbilane synthase activity
CLH39_09005	COG2959	enzyme of heme biosynthesis
CLH39_09030	COG3712	iron ion homeostasis
CLH39_09035	COG4774	siderophore transport
CLH39_09045	COG1595	DNA-templated transcription, initiation
CLH39_09085	COG4964	Belongs to the GSP D family
CLH39_09130	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CLH39_09135	COG0577	efflux transmembrane transporter activity
CLH39_09135	COG1136	(ABC) transporter
CLH39_09140	COG1538	Outer membrane efflux protein
CLH39_09150	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
CLH39_09155	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CLH39_09165	COG1295	ribonuclease BN
CLH39_09175	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
CLH39_09180	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
CLH39_09195	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
CLH39_09200	COG0625	glutathione transferase activity
CLH39_09205	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CLH39_09225	COG0473	3-isopropylmalate dehydrogenase activity
CLH39_09230	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CLH39_09240	COG0101	tRNA pseudouridine synthase activity
CLH39_09250	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CLH39_09255	COG0135	phosphoribosylanthranilate isomerase activity
CLH39_09260	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CLH39_09275	COG2207	Transcriptional regulator
CLH39_09280	COG0519	Catalyzes the synthesis of GMP from XMP
CLH39_09280	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CLH39_09285	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CLH39_09290	COG0318	PFAM AMP-dependent synthetase and ligase
CLH39_09295	COG1666	GTP binding
CLH39_09305	COG0842	Transport permease protein
CLH39_09310	COG1131	(ABC) transporter
CLH39_09315	COG0590	tRNA wobble adenosine to inosine editing
CLH39_09320	COG1619	proteins homologs of microcin C7 resistance protein MccF
CLH39_09325	COG0488	(ABC) transporter
CLH39_09345	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CLH39_09350	COG2252	PERMEase
CLH39_09355	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CLH39_09360	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
CLH39_09365	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
CLH39_09370	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
CLH39_09380	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CLH39_09390	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CLH39_09405	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
CLH39_09410	COG0789	Transcriptional regulator
CLH39_09415	COG0165	Argininosuccinate lyase
CLH39_09420	COG0668	transmembrane transport
CLH39_09430	COG0656	L-ascorbic acid biosynthetic process
CLH39_09435	COG2814	Major facilitator Superfamily
CLH39_09440	COG3161	chorismate lyase activity
CLH39_09445	COG1187	pseudouridine synthase activity
CLH39_09450	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
CLH39_09455	COG0584	glycerophosphoryl diester phosphodiesterase
CLH39_09460	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CLH39_09465	COG0739	heme binding
CLH39_09470	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
CLH39_09490	COG0179	Fumarylacetoacetate (FAA) hydrolase
CLH39_09495	COG0583	DNA-binding transcription factor activity
CLH39_09500	COG0583	DNA-binding transcription factor activity
CLH39_09505	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CLH39_09510	COG1758	RNA polymerase activity
CLH39_09515	COG0194	GDP metabolic process
CLH39_09545	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
CLH39_09555	COG0183	Belongs to the thiolase family
CLH39_09560	COG0183	Belongs to the thiolase family
CLH39_09580	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
CLH39_09585	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CLH39_09590	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CLH39_09600	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
CLH39_09620	COG0183	Belongs to the thiolase family
CLH39_09640	COG1028	Short-chain dehydrogenase reductase Sdr
CLH39_09645	COG1028	Short-chain dehydrogenase reductase Sdr
CLH39_09650	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
CLH39_09655	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CLH39_09660	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
CLH39_09665	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CLH39_09680	COG0640	Transcriptional regulator
CLH39_09685	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CLH39_09695	COG1999	signal sequence binding
CLH39_09705	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CLH39_09710	COG4566	intracellular signal transduction
CLH39_09720	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
CLH39_09725	COG0508	dehydrogenase complex catalyzes the overall conversion of
CLH39_09730	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CLH39_09735	COG0285	dihydrofolate synthase activity
CLH39_09745	COG1286	toxin biosynthetic process
CLH39_09770	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
CLH39_09775	COG0024	Methionine aminopeptidase
CLH39_09780	COG0052	Belongs to the universal ribosomal protein uS2 family
CLH39_09785	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CLH39_09790	COG0528	UMP kinase activity
CLH39_09795	COG0233	cytoplasmic translational termination
CLH39_09800	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CLH39_09805	COG0575	Belongs to the CDS family
CLH39_09810	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
CLH39_09820	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CLH39_09830	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CLH39_09835	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CLH39_09845	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CLH39_09850	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CLH39_09855	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CLH39_09880	COG1252	NADH dehydrogenase
CLH39_09885	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
CLH39_09890	COG2867	negative regulation of translational initiation
CLH39_09895	COG2914	Belongs to the UPF0125 (RnfH) family
CLH39_09900	COG1960	acyl-CoA dehydrogenase activity
CLH39_09915	COG0354	folic acid binding
CLH39_09920	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CLH39_09930	COG0470	DNA polymerase III
CLH39_09935	COG0084	hydrolase, TatD family'
CLH39_09955	COG0625	glutathione transferase activity
CLH39_09960	COG1393	Belongs to the ArsC family
CLH39_09965	COG2353	YceI-like domain
CLH39_09975	COG3038	cytochrome b561
CLH39_10015	COG1028	Short-chain dehydrogenase reductase Sdr
CLH39_10020	COG2894	cell division
CLH39_10065	COG0583	DNA-binding transcription factor activity
CLH39_10070	COG1063	alcohol dehydrogenase
CLH39_10120	COG4771	TonB-dependent receptor
CLH39_10135	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
CLH39_10140	COG1335	isochorismatase
CLH39_10155	COG2814	Major facilitator Superfamily
CLH39_10205	COG2003	Belongs to the UPF0758 family
CLH39_10225	COG4774	siderophore transport
CLH39_10260	COG1858	cytochrome C peroxidase
CLH39_10270	COG4771	TonB-dependent receptor
CLH39_10290	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CLH39_10315	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
CLH39_10470	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
CLH39_10475	COG2132	Multicopper oxidase
CLH39_10485	COG4974	Belongs to the 'phage' integrase family
CLH39_10490	COG0583	DNA-binding transcription factor activity
CLH39_10520	COG0583	DNA-binding transcription factor activity
CLH39_10530	COG2807	transmembrane transport
CLH39_10535	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CLH39_10540	COG1012	belongs to the aldehyde dehydrogenase family
CLH39_10550	COG0235	Class ii aldolase
CLH39_10555	COG2207	Transcriptional regulator
CLH39_10560	COG4654	Cytochrome c, class I
CLH39_10565	COG0589	response to stress
CLH39_10570	COG2226	methyltransferase
CLH39_10575	COG2133	pyrroloquinoline quinone binding
CLH39_10580	COG0114	fumarate hydratase activity
CLH39_10590	COG1028	Short-chain dehydrogenase reductase Sdr
CLH39_10595	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CLH39_10605	COG0625	glutathione transferase activity
CLH39_10625	COG0559	Belongs to the binding-protein-dependent transport system permease family
CLH39_10640	COG1653	transport
CLH39_10645	COG1175	transmembrane transport
CLH39_10650	COG0395	ABC-type sugar transport system, permease component
CLH39_10655	COG3842	ATPase activity
CLH39_10665	COG0783	Belongs to the Dps family
CLH39_10675	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CLH39_10690	COG1840	ABC-type Fe3 transport system, periplasmic component
CLH39_10695	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
CLH39_10700	COG3842	ATPase activity
CLH39_10725	COG2153	protein acetylation
CLH39_10730	COG0174	glutamine synthetase
CLH39_10735	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CLH39_10740	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CLH39_10745	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
CLH39_10760	COG1561	YicC-like family, N-terminal region
CLH39_10795	COG2814	Major facilitator Superfamily
CLH39_10805	COG1473	amidohydrolase
CLH39_10810	COG0071	Belongs to the small heat shock protein (HSP20) family
CLH39_10815	COG2233	PERMEase
CLH39_10865	COG1053	succinate dehydrogenase
CLH39_10870	COG0583	DNA-binding transcription factor activity
CLH39_10880	COG4191	Histidine kinase
CLH39_10885	COG1301	dicarboxylic acid transport
CLH39_10900	COG0307	riboflavin synthase, alpha
CLH39_10905	COG4221	oxidoreductase activity
CLH39_10910	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CLH39_10915	COG1028	Short-chain dehydrogenase reductase Sdr
CLH39_10925	COG1360	Flagellar Motor Protein
CLH39_10940	COG1686	Belongs to the peptidase S11 family
CLH39_10945	COG0583	DNA-binding transcription factor activity
CLH39_10985	COG0587	DNA-directed DNA polymerase activity
CLH39_10990	COG1610	YqeY-like protein
CLH39_11000	COG1902	pentaerythritol trinitrate reductase activity
CLH39_11005	COG0569	domain protein
CLH39_11010	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CLH39_11025	COG1262	PFAM Formylglycine-generating sulfatase enzyme
CLH39_11035	COG3949	Membrane
CLH39_11050	COG3258	Cytochrome c
CLH39_11060	COG3048	D-serine ammonia-lyase activity
CLH39_11065	COG2207	Transcriptional regulator
CLH39_11070	COG0604	alcohol dehydrogenase
CLH39_11185	COG2948	multi-organism process
CLH39_11225	COG0433	COG0433 Predicted ATPase
CLH39_11290	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CLH39_11300	COG4172	Belongs to the ABC transporter superfamily
CLH39_11305	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CLH39_11310	COG0601	transmembrane transport
CLH39_11315	COG0747	negative chemotaxis
CLH39_11340	COG1181	Belongs to the D-alanine--D-alanine ligase family
CLH39_11345	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CLH39_11350	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CLH39_11375	COG2274	protein secretion by the type I secretion system
CLH39_11385	COG1538	Outer membrane efflux protein
CLH39_11405	COG2151	metal-sulfur cluster biosynthetic enzyme
CLH39_11410	COG0822	iron-sulfur transferase activity
CLH39_11420	COG0719	Fe-S assembly protein
CLH39_11425	COG0396	ATPase activity
CLH39_11430	COG0719	Fe-S assembly protein
CLH39_11435	COG1959	2 iron, 2 sulfur cluster binding
CLH39_11440	COG5265	(ABC) transporter
CLH39_11455	COG2833	Protein of unknown function (DUF455)
CLH39_11470	COG0072	phenylalanine-tRNA ligase activity
CLH39_11470	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CLH39_11475	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
CLH39_11480	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
CLH39_11485	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CLH39_11515	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CLH39_11520	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CLH39_11535	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
CLH39_11540	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CLH39_11555	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CLH39_11565	COG3042	response to heat
CLH39_11575	COG2226	methyltransferase
CLH39_11580	COG1585	Membrane protein implicated in regulation of membrane protease activity
CLH39_11585	COG0330	HflC and HflK could
CLH39_11610	COG0402	S-adenosylhomocysteine deaminase activity
CLH39_11620	COG1609	Transcriptional regulator
CLH39_11630	COG1280	lysine exporter protein (LysE YggA)
CLH39_11635	COG2814	Major facilitator Superfamily
CLH39_11665	COG2871	sodium ion transport
CLH39_11715	COG1126	abc transporter atp-binding protein
CLH39_11720	COG0765	amino acid transport
CLH39_11725	COG0765	amino acid transport
CLH39_11730	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CLH39_11755	COG3422	double-strand break repair
CLH39_11760	COG1272	protein, Hemolysin III
CLH39_11785	COG3772	lysozyme
CLH39_11855	COG2856	Zn peptidase
CLH39_11905	COG5410	chromosome segregation
CLH39_11910	COG3728	DNA packaging
CLH39_11910	COG5484	DNA packaging
CLH39_12070	COG0582	viral genome integration into host DNA
CLH39_12090	COG0667	Aldo Keto reductase
CLH39_12095	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
CLH39_12125	COG3842	ATPase activity
CLH39_12150	COG0697	spore germination
CLH39_12160	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CLH39_12170	COG2271	Major facilitator Superfamily
CLH39_12175	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CLH39_12180	COG1846	Transcriptional regulator
CLH39_12205	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CLH39_12220	COG4555	ABC transporter
CLH39_12230	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
CLH39_12235	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CLH39_12240	COG3135	benzoate transporter
CLH39_12250	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CLH39_12255	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
CLH39_12265	COG3485	protocatechuate 3,4-dioxygenase
CLH39_12290	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CLH39_12315	COG0640	Transcriptional regulator
CLH39_12345	COG1960	acyl-CoA dehydrogenase activity
CLH39_12355	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CLH39_12405	COG0740	serine-type endopeptidase activity
CLH39_12410	COG0625	glutathione transferase activity
CLH39_12415	COG2816	NAD+ diphosphatase activity
CLH39_12435	COG0583	DNA-binding transcription factor activity
CLH39_12440	COG0625	glutathione transferase activity
CLH39_12455	COG1309	transcriptional regulator
CLH39_12490	COG2070	2-Nitropropane dioxygenase
CLH39_12505	COG1942	4-Oxalocrotonate Tautomerase
CLH39_12515	COG1566	PFAM secretion protein HlyD family protein
CLH39_12525	COG1289	transmembrane transporter activity
CLH39_12530	COG0583	DNA-binding transcription factor activity
CLH39_12550	COG2207	Transcriptional regulator
CLH39_12555	COG0745	RESPONSE REGULATOR receiver
CLH39_12575	COG1078	dGTPase activity
CLH39_12595	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
CLH39_12600	COG0735	belongs to the Fur family
CLH39_12605	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CLH39_12615	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
CLH39_12620	COG1469	GTP cyclohydrolase I activity
CLH39_12625	COG0523	cobalamin synthesis protein
CLH39_12630	COG2378	regulation of single-species biofilm formation
CLH39_12640	COG1960	acyl-CoA dehydrogenase activity
CLH39_12650	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
CLH39_12665	COG0583	DNA-binding transcription factor activity
CLH39_12670	COG3328	transposase activity
CLH39_12695	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CLH39_12695	COG0519	Catalyzes the synthesis of GMP from XMP
CLH39_12720	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CLH39_12720	COG0047	phosphoribosylformylglycinamidine synthase activity
CLH39_12730	COG0613	PHP domain protein
CLH39_12745	COG0084	hydrolase, TatD family'
CLH39_12750	COG1136	(ABC) transporter
CLH39_12765	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CLH39_12785	COG3210	domain, Protein
CLH39_12790	COG2831	hemolysin activation secretion protein
CLH39_12800	COG0385	Bile acid
CLH39_12805	COG0697	spore germination
CLH39_12810	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CLH39_12815	COG0840	transmembrane signaling receptor activity
CLH39_12825	COG4221	oxidoreductase activity
CLH39_12830	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CLH39_12835	COG3181	Tripartite tricarboxylate transporter family receptor
CLH39_12845	COG0316	Belongs to the HesB IscA family
CLH39_12855	COG1104	cysteine desulfurase activity
CLH39_12865	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CLH39_12870	COG0556	nucleotide-excision repair
CLH39_12890	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
CLH39_12900	COG0740	serine-type endopeptidase activity
CLH39_12905	COG0544	peptidyl-prolyl cis-trans isomerase activity
CLH39_12910	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CLH39_12925	COG0789	Transcriptional regulator
CLH39_12965	COG0471	metal ion transport
CLH39_12965	COG3273	potassium ion transport
CLH39_12975	COG2207	Transcriptional regulator
CLH39_12990	COG2171	N-acyltransferase activity
CLH39_12995	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CLH39_13000	COG2890	protein-(glutamine-N5) methyltransferase activity
CLH39_13005	COG0488	(ABC) transporter
CLH39_13060	COG0210	DNA helicase
CLH39_13070	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CLH39_13070	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CLH39_13075	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
CLH39_13080	COG0196	riboflavin kinase activity
CLH39_13085	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
CLH39_13090	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CLH39_13100	COG0756	dUTP diphosphatase activity
CLH39_13105	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
CLH39_13115	COG0300	oxidoreductase activity
CLH39_13150	COG0559	Belongs to the binding-protein-dependent transport system permease family
CLH39_13170	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
CLH39_13170	COG3008	intermembrane lipid transfer
CLH39_13175	COG2995	paraquat-inducible protein a
CLH39_13180	COG0542	response to heat
CLH39_13185	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
CLH39_13190	COG1278	Cold shock
CLH39_13200	COG0183	Belongs to the thiolase family
CLH39_13215	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CLH39_13220	COG1570	exodeoxyribonuclease VII activity
CLH39_13225	COG0811	peptide transport
CLH39_13230	COG0848	biopolymer transport protein
CLH39_13235	COG1663	tetraacyldisaccharide 4'-kinase activity
CLH39_13240	COG2835	tetraacyldisaccharide 4'-kinase activity
CLH39_13245	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
CLH39_13250	COG0563	adenylate kinase activity
CLH39_13260	COG0728	peptidoglycan biosynthetic process
CLH39_13265	COG0268	Binds directly to 16S ribosomal RNA
CLH39_13270	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CLH39_13280	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CLH39_13285	COG0745	RESPONSE REGULATOR receiver
CLH39_13290	COG2205	protein histidine kinase activity
CLH39_13305	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
CLH39_13315	COG0519	Catalyzes the synthesis of GMP from XMP
CLH39_13320	COG1609	Transcriptional regulator
CLH39_13340	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
CLH39_13345	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
CLH39_13350	COG0137	argininosuccinate synthase activity
CLH39_13360	COG2832	Protein of unknown function (DUF454)
CLH39_13365	COG0494	nUDIX hydrolase
CLH39_13375	COG0626	cystathionine gamma-synthase activity
CLH39_13380	COG1522	sequence-specific DNA binding
CLH39_13395	COG2199	diguanylate cyclase activity
CLH39_13445	COG3772	lysozyme
CLH39_13545	COG2161	toxin-antitoxin pair type II binding
CLH39_13550	COG4115	mRNA cleavage
CLH39_13575	COG0501	Belongs to the peptidase M48B family
CLH39_13585	COG0456	acetyltransferase
CLH39_13600	COG1490	D-aminoacyl-tRNA deacylase activity
CLH39_13615	COG2239	Acts as a magnesium transporter
CLH39_13620	COG2205	protein histidine kinase activity
CLH39_13620	COG2198	Histidine kinase
CLH39_13620	COG0784	Response regulator, receiver
CLH39_13625	COG3437	response regulator, receiver
CLH39_13630	COG1396	sequence-specific DNA binding
CLH39_13645	COG0477	Major facilitator Superfamily
CLH39_13650	COG1196	nuclear chromosome segregation
CLH39_13650	COG3264	Mechanosensitive ion channel
CLH39_13660	COG3264	Mechanosensitive ion channel
CLH39_13660	COG1511	domain protein
CLH39_13670	COG1028	Short-chain dehydrogenase reductase Sdr
CLH39_13710	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
CLH39_13715	COG1058	Belongs to the CinA family
CLH39_13715	COG1546	Belongs to the CinA family
CLH39_13720	COG1846	Transcriptional regulator
CLH39_13730	COG0069	glutamate synthase activity
CLH39_13740	COG1999	signal sequence binding
CLH39_13760	COG2252	PERMEase
CLH39_13765	COG1289	transmembrane transporter activity
CLH39_13780	COG0025	NhaP-type Na H and K H
CLH39_13815	COG4774	siderophore transport
CLH39_13820	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
CLH39_13830	COG3258	Cytochrome c
CLH39_13845	COG3278	Belongs to the heme-copper respiratory oxidase family
CLH39_13855	COG0642	Histidine kinase
CLH39_13860	COG1278	Cold shock
CLH39_13885	COG0446	pyridine nucleotide-disulphide oxidoreductase
CLH39_13925	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CLH39_13930	COG3755	Protein conserved in bacteria
CLH39_13955	COG1113	amino acid transport
CLH39_13965	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CLH39_13975	COG1858	cytochrome C peroxidase
CLH39_13980	COG4771	TonB-dependent receptor
CLH39_13995	COG2824	Alkylphosphonate utilization operon protein PhnA
CLH39_14005	COG0583	DNA-binding transcription factor activity
CLH39_14010	COG1028	Short-chain dehydrogenase reductase Sdr
CLH39_14015	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CLH39_14020	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
CLH39_14025	COG4521	taurine ABC transporter
CLH39_14030	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CLH39_14060	COG0582	viral genome integration into host DNA
CLH39_14070	COG2610	gluconate transmembrane transporter activity
CLH39_14080	COG2080	2 iron, 2 sulfur cluster binding
CLH39_14090	COG3181	Tripartite tricarboxylate transporter family receptor
CLH39_14105	COG0840	transmembrane signaling receptor activity
CLH39_14115	COG0840	transmembrane signaling receptor activity
CLH39_14120	COG2733	membrane
CLH39_14140	COG1262	PFAM Formylglycine-generating sulfatase enzyme
CLH39_14150	COG1136	(ABC) transporter
CLH39_14190	COG1191	sigma factor activity
CLH39_14195	COG1334	flagellar protein FlaG
CLH39_14200	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
CLH39_14220	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CLH39_14225	COG1677	Flagellar hook-basal body complex protein FliE
CLH39_14230	COG1766	The M ring may be actively involved in energy transduction
CLH39_14245	COG1157	protein secretion by the type III secretion system
CLH39_14260	COG1580	Controls the rotational direction of flagella during chemotaxis
CLH39_14270	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CLH39_14285	COG1987	bacterial-type flagellum assembly
CLH39_14295	COG2176	DNA-directed DNA polymerase activity
CLH39_14320	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CLH39_14360	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
CLH39_14365	COG1558	bacterial-type flagellum-dependent cell motility
CLH39_14395	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CLH39_14405	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
CLH39_14410	COG0745	RESPONSE REGULATOR receiver
CLH39_14420	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
CLH39_14425	COG0840	transmembrane signaling receptor activity
CLH39_14430	COG0835	chemotaxis
CLH39_14440	COG1360	Flagellar Motor Protein
CLH39_14460	COG0791	NLP P60 protein
CLH39_14465	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
CLH39_14470	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CLH39_14475	COG2314	TM2 domain
CLH39_14485	COG1262	PFAM Formylglycine-generating sulfatase enzyme
CLH39_14490	COG0659	secondary active sulfate transmembrane transporter activity
CLH39_14515	COG0640	Transcriptional regulator
CLH39_14525	COG3094	Invasion gene expression up-regulator, SirB
CLH39_14555	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
CLH39_14570	COG1283	sodium-dependent phosphate transmembrane transporter activity
CLH39_14575	COG0628	permease
CLH39_14610	COG0277	FAD linked oxidase domain protein
CLH39_14615	COG0277	FAD linked oxidase domain protein
CLH39_14620	COG2186	Transcriptional regulator
CLH39_14680	COG1132	(ABC) transporter
CLH39_14700	COG0438	transferase activity, transferring glycosyl groups
CLH39_14715	COG0726	polysaccharide deacetylase
CLH39_14720	COG0438	transferase activity, transferring glycosyl groups
CLH39_14730	COG1643	Atp-dependent helicase
CLH39_14735	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
CLH39_14735	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CLH39_14740	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
CLH39_14745	COG5001	Diguanylate cyclase
CLH39_14745	COG3706	GGDEF domain
CLH39_14745	COG4251	negative regulation of phosphorylation
CLH39_14745	COG2203	Gaf domain
CLH39_14750	COG0704	Plays a role in the regulation of phosphate uptake
CLH39_14755	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
CLH39_14760	COG1393	Belongs to the ArsC family
CLH39_14765	COG1177	transmembrane transport
CLH39_14770	COG1176	ABC-type spermidine putrescine transport system, permease component I
CLH39_14775	COG3842	ATPase activity
CLH39_14800	COG1028	Short-chain dehydrogenase reductase Sdr
CLH39_14805	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CLH39_14810	COG1562	ergosterol biosynthetic process
CLH39_14815	COG1562	ergosterol biosynthetic process
CLH39_14820	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
CLH39_14825	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CLH39_14840	COG0436	Aminotransferase
CLH39_14850	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CLH39_14855	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
CLH39_14860	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
CLH39_14870	COG0305	Participates in initiation and elongation during chromosome replication
CLH39_14880	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CLH39_14885	COG2965	DNA replication, synthesis of RNA primer
CLH39_14890	COG0360	Binds together with S18 to 16S ribosomal RNA
CLH39_14895	COG1469	GTP cyclohydrolase I activity
CLH39_14900	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CLH39_14905	COG0142	geranyltranstransferase activity
CLH39_14910	COG1722	exodeoxyribonuclease VII activity
CLH39_14925	COG0501	Belongs to the peptidase M48B family
CLH39_14945	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
CLH39_14975	COG4215	(ABC) transporter
CLH39_14980	COG4160	amino acid transport
CLH39_14990	COG0446	pyridine nucleotide-disulphide oxidoreductase
CLH39_14995	COG1217	gtp-binding protein TYPA
CLH39_15000	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CLH39_15005	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
CLH39_15015	COG2251	uridine kinase activity
CLH39_15015	COG0195	Participates in both transcription termination and antitermination
CLH39_15020	COG0779	Required for maturation of 30S ribosomal subunits
CLH39_15030	COG1187	pseudouridine synthase activity
CLH39_15035	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
CLH39_15080	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
CLH39_15085	COG1028	Short-chain dehydrogenase reductase Sdr
CLH39_15090	COG3243	poly(R)-hydroxyalkanoic acid synthase
CLH39_15100	COG0564	pseudouridine synthase activity
CLH39_15125	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CLH39_15130	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CLH39_15130	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
CLH39_15145	COG1733	regulation of RNA biosynthetic process
CLH39_15155	COG1199	ATP-dependent helicase activity
CLH39_15160	COG2183	response to ionizing radiation
CLH39_15180	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
CLH39_15185	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CLH39_15190	COG0508	dehydrogenase complex catalyzes the overall conversion of
CLH39_15195	COG0567	Dehydrogenase, E1 component
CLH39_15200	COG0280	phosphate acetyltransferase
CLH39_15200	COG0281	malic enzyme
CLH39_15210	COG0038	chloride channel
CLH39_15215	COG1620	l-lactate permease
CLH39_15220	COG2186	Transcriptional regulator
CLH39_15225	COG0372	Belongs to the citrate synthase family
CLH39_15230	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
CLH39_15235	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CLH39_15240	COG1053	succinate dehydrogenase
CLH39_15250	COG2009	succinate dehydrogenase
CLH39_15255	COG2188	Transcriptional regulator
CLH39_15260	COG0039	L-malate dehydrogenase activity
CLH39_15280	COG3829	transcription factor binding
CLH39_15310	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
CLH39_15335	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CLH39_15340	COG1028	Short-chain dehydrogenase reductase Sdr
CLH39_15355	COG0183	Belongs to the thiolase family
CLH39_15365	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CLH39_15385	COG1454	alcohol dehydrogenase
CLH39_15390	COG1012	belongs to the aldehyde dehydrogenase family
CLH39_15395	COG3284	Transcriptional regulator
CLH39_15405	COG4172	Belongs to the ABC transporter superfamily
CLH39_15410	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CLH39_15430	COG1960	acyl-CoA dehydrogenase activity
CLH39_15435	COG0598	Magnesium transport protein CorA
CLH39_15440	COG2363	Small membrane protein
CLH39_15445	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
CLH39_15450	COG2094	Belongs to the DNA glycosylase MPG family
CLH39_15465	COG0655	NAD(P)H dehydrogenase (quinone) activity
CLH39_15470	COG0435	Glutathione S-transferase
CLH39_15475	COG1304	FMN binding
CLH39_15490	COG4773	Receptor
CLH39_15520	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
CLH39_15530	COG3842	ATPase activity
CLH39_15535	COG4208	sulfate ABC transporter
CLH39_15555	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CLH39_15570	COG0330	HflC and HflK could
CLH39_15590	COG0037	tRNA processing
CLH39_15595	COG0825	malonyl-CoA metabolic process
CLH39_15605	COG0215	cysteine-tRNA ligase activity
CLH39_15630	COG1968	undecaprenyl-diphosphatase activity
CLH39_15635	COG1253	flavin adenine dinucleotide binding
CLH39_15640	COG0483	inositol monophosphate 1-phosphatase activity
CLH39_15655	COG2031	fatty acid transporter
CLH39_15660	COG0154	amidase activity
CLH39_15695	COG3321	synthase
CLH39_15695	COG1028	Short-chain dehydrogenase reductase Sdr
CLH39_15695	COG0604	alcohol dehydrogenase
CLH39_15705	COG0668	transmembrane transport
CLH39_15715	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CLH39_15725	COG3181	Tripartite tricarboxylate transporter family receptor
CLH39_15735	COG1132	(ABC) transporter
CLH39_15740	COG0363	glucosamine-6-phosphate deaminase activity
CLH39_15745	COG1538	Outer membrane efflux protein
CLH39_15750	COG0577	efflux transmembrane transporter activity
CLH39_15750	COG1136	(ABC) transporter
CLH39_15755	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CLH39_15765	COG3391	amine dehydrogenase activity
CLH39_15775	COG2850	peptidyl-arginine hydroxylation
CLH39_15785	COG3135	benzoate transporter
CLH39_15790	COG2124	cytochrome p450
CLH39_15795	COG0156	8-amino-7-oxononanoate synthase activity
CLH39_15805	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
CLH39_15820	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
CLH39_15825	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CLH39_15830	COG1994	Peptidase M50
CLH39_15835	COG0009	L-threonylcarbamoyladenylate synthase
CLH39_15850	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CLH39_15855	COG3327	negative regulation of DNA-templated transcription, initiation
CLH39_15860	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CLH39_15890	COG1368	sulfuric ester hydrolase activity
CLH39_15905	COG2323	membrane
CLH39_15910	COG2010	Cytochrome c
CLH39_15965	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CLH39_15970	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CLH39_15990	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
CLH39_15995	COG0248	Ppx GppA phosphatase
CLH39_16005	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CLH39_16010	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CLH39_16015	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CLH39_16020	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
CLH39_16025	COG1534	Rna-binding protein
CLH39_16030	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CLH39_16040	COG2233	PERMEase
CLH39_16060	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CLH39_16065	COG0505	Belongs to the CarA family
CLH39_16070	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CLH39_16075	COG3391	amine dehydrogenase activity
CLH39_16095	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CLH39_16130	COG1074	ATP-dependent DNA helicase activity
CLH39_16145	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
CLH39_16150	COG4149	molybdate abc transporter
CLH39_16155	COG0725	ABC transporter, periplasmic molybdate-binding protein
CLH39_16160	COG4974	Belongs to the 'phage' integrase family
CLH39_16165	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CLH39_16170	COG2223	nitrite transmembrane transporter activity
CLH39_16180	COG2910	NAD(P)H-binding
CLH39_16185	COG1733	regulation of RNA biosynthetic process
CLH39_16215	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CLH39_16235	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CLH39_16240	COG1012	belongs to the aldehyde dehydrogenase family
CLH39_16245	COG0583	DNA-binding transcription factor activity
CLH39_16250	COG0280	phosphate acetyltransferase
CLH39_16250	COG0281	malic enzyme
CLH39_16255	COG0463	Glycosyl transferase, family 2
CLH39_16290	COG3181	Tripartite tricarboxylate transporter family receptor
CLH39_16300	COG0802	atpase or kinase
CLH39_16305	COG0860	N-Acetylmuramoyl-L-alanine amidase
CLH39_16310	COG0586	Pfam SNARE associated Golgi protein
CLH39_16315	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
CLH39_16320	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CLH39_16325	COG1953	Uracil, thiamine, allantoin
CLH39_16335	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
CLH39_16340	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CLH39_16350	COG0617	tRNA 3'-terminal CCA addition
CLH39_16355	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
CLH39_16360	COG1573	uracil-dna glycosylase
CLH39_16375	COG2814	Major facilitator Superfamily
CLH39_16385	COG1309	transcriptional regulator
CLH39_16400	COG0752	glycyl-tRNA synthetase alpha subunit
CLH39_16405	COG0751	glycine-tRNA ligase activity
CLH39_16410	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
CLH39_16415	COG0204	Acyl-transferase
CLH39_16430	COG0700	Nucleoside recognition
CLH39_16435	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CLH39_16440	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CLH39_16445	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
CLH39_16465	COG1126	abc transporter atp-binding protein
CLH39_16470	COG0765	amino acid transport
CLH39_16475	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CLH39_16485	COG2011	ABC-type metal ion transport system permease component
CLH39_16490	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CLH39_16505	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CLH39_16505	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
CLH39_16515	COG0318	PFAM AMP-dependent synthetase and ligase
CLH39_16520	COG1473	amidohydrolase
CLH39_16530	COG2239	Acts as a magnesium transporter
CLH39_16540	COG0653	protein targeting
CLH39_16545	COG1196	nuclear chromosome segregation
CLH39_16545	COG0739	heme binding
CLH39_16545	COG0741	lytic transglycosylase activity
CLH39_16555	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
CLH39_16570	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
CLH39_16575	COG1181	Belongs to the D-alanine--D-alanine ligase family
CLH39_16580	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CLH39_16585	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CLH39_16595	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CLH39_16600	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CLH39_16605	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CLH39_16615	COG3116	cell division
CLH39_16620	COG0275	rRNA processing
CLH39_16625	COG2001	Belongs to the MraZ family
CLH39_16635	COG0488	(ABC) transporter
CLH39_16640	COG0633	Ferredoxin
CLH39_16645	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CLH39_16650	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CLH39_16655	COG0514	ATP-dependent DNA helicase (RecQ)
CLH39_16665	COG0038	chloride channel
CLH39_16670	COG1294	oxidase, subunit
CLH39_16675	COG1271	oxidase subunit
CLH39_16680	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CLH39_16690	COG2894	cell division
CLH39_16695	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
CLH39_16715	COG0488	(ABC) transporter
CLH39_16725	COG1215	transferase activity, transferring glycosyl groups
CLH39_16730	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CLH39_16745	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
CLH39_16755	COG0259	pyridoxamine-phosphate oxidase activity
CLH39_16760	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CLH39_16765	COG0579	oxidoreductase
CLH39_16775	COG0405	Gamma-glutamyltransferase
CLH39_16785	COG1960	acyl-CoA dehydrogenase activity
CLH39_16790	COG1012	belongs to the aldehyde dehydrogenase family
CLH39_16790	COG2030	dehydratase
CLH39_16795	COG0596	Alpha beta hydrolase
CLH39_16800	COG0009	L-threonylcarbamoyladenylate synthase
CLH39_16805	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
CLH39_16810	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
CLH39_16815	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
CLH39_16825	COG0521	Mo-molybdopterin cofactor biosynthetic process
CLH39_16850	COG0126	phosphoglycerate kinase activity
CLH39_16855	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CLH39_16860	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
CLH39_16865	COG1385	rRNA (uridine-N3-)-methyltransferase activity
CLH39_16870	COG2732	(Barnase) inhibitor
CLH39_16880	COG0280	phosphate acetyltransferase
CLH39_16880	COG0281	malic enzyme
CLH39_16890	COG0436	Aminotransferase
CLH39_16900	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
CLH39_16915	COG0477	Major facilitator Superfamily
CLH39_16925	COG0154	amidase activity
CLH39_16940	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CLH39_16955	COG0583	DNA-binding transcription factor activity
CLH39_16970	COG4575	ribosome binding
CLH39_16980	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
CLH39_16985	COG2027	D-alanyl-D-alanine carboxypeptidase
CLH39_16990	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
CLH39_16995	COG0343	queuine tRNA-ribosyltransferase activity
CLH39_17000	COG1862	Preprotein translocase
CLH39_17005	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CLH39_17010	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CLH39_17015	COG0024	Methionine aminopeptidase
CLH39_17025	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CLH39_17030	COG1702	phosphate starvation-inducible protein PhoH
CLH39_17035	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
CLH39_17040	COG4535	Mg2 and Co2 transporter CorC
CLH39_17045	COG0815	Transfers the fatty acyl group on membrane lipoproteins
CLH39_17085	COG2814	Major facilitator Superfamily
CLH39_17120	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CLH39_17125	COG0697	spore germination
CLH39_17140	COG0678	peroxiredoxin activity
CLH39_17170	COG0315	cyclic pyranopterin monophosphate synthase activity
CLH39_17180	COG0314	molybdopterin synthase activity
CLH39_17185	COG0521	Mo-molybdopterin cofactor biosynthetic process
CLH39_17190	COG0303	'Molybdopterin
CLH39_17200	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CLH39_17205	COG1910	domain protein
CLH39_17220	COG3383	formate dehydrogenase (NAD+) activity
CLH39_17225	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
CLH39_17265	COG0463	Glycosyl transferase, family 2
CLH39_17270	COG2346	COG2346, Truncated hemoglobins
CLH39_17275	COG1959	2 iron, 2 sulfur cluster binding
CLH39_17280	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CLH39_17285	COG1858	cytochrome C peroxidase
CLH39_17295	COG0411	ABC transporter
CLH39_17305	COG0559	Belongs to the binding-protein-dependent transport system permease family
CLH39_17325	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CLH39_17325	COG2169	Transcriptional regulator
CLH39_17335	COG0785	Cytochrome C biogenesis protein
CLH39_17340	COG4235	cytochrome complex assembly
CLH39_17345	COG3088	subunit of a heme lyase
CLH39_17350	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CLH39_17360	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
CLH39_17370	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CLH39_17390	COG0583	DNA-binding transcription factor activity
CLH39_17395	COG0288	reversible hydration of carbon dioxide
CLH39_17410	COG0488	(ABC) transporter
CLH39_17430	COG0012	GTP binding
CLH39_17440	COG0193	aminoacyl-tRNA hydrolase activity
CLH39_17445	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
CLH39_17450	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CLH39_17465	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
CLH39_17475	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CLH39_17485	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CLH39_17495	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
CLH39_17500	COG0179	Fumarylacetoacetate (FAA) hydrolase
CLH39_17510	COG0277	FAD linked oxidase domain protein
CLH39_17520	COG0438	transferase activity, transferring glycosyl groups
CLH39_17525	COG0438	transferase activity, transferring glycosyl groups
CLH39_17530	COG0438	transferase activity, transferring glycosyl groups
CLH39_17545	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
CLH39_17550	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CLH39_17560	COG3648	Uricase
CLH39_17560	COG3195	allantoin biosynthetic process
CLH39_17565	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
CLH39_17570	COG0235	Class ii aldolase
CLH39_17575	COG1942	4-Oxalocrotonate Tautomerase
CLH39_17580	COG2233	PERMEase
CLH39_17590	COG0583	DNA-binding transcription factor activity
CLH39_17595	COG3960	tartronate-semialdehyde synthase activity
CLH39_17600	COG3622	Belongs to the hyi family
CLH39_17605	COG2084	Dehydrogenase
CLH39_17615	COG3193	protein, possibly involved in utilization of glycolate and propanediol
CLH39_17620	COG0469	pyruvate kinase activity
CLH39_17625	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
CLH39_17650	COG3278	Belongs to the heme-copper respiratory oxidase family
CLH39_17655	COG1765	OsmC-like protein
CLH39_17660	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
CLH39_17670	COG0509	glycine decarboxylation via glycine cleavage system
CLH39_17675	COG2081	HI0933 family
CLH39_17700	COG0489	protein tyrosine kinase activity
CLH39_17710	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CLH39_17710	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CLH39_17715	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
CLH39_17720	COG0583	DNA-binding transcription factor activity
CLH39_17725	COG3257	ureidoglycine aminohydrolase activity
CLH39_17730	COG0590	tRNA wobble adenosine to inosine editing
CLH39_17735	COG3391	amine dehydrogenase activity
CLH39_17745	COG0235	Class ii aldolase
CLH39_17750	COG0477	Major facilitator Superfamily
CLH39_17765	COG0387	Pfam Sodium calcium exchanger
CLH39_17775	COG0583	DNA-binding transcription factor activity
CLH39_17800	COG1535	isochorismatase
CLH39_17800	COG3433	isochorismatase activity
CLH39_17825	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CLH39_17840	COG1652	LysM domain
CLH39_17845	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CLH39_17860	COG3023	N-Acetylmuramoyl-L-alanine amidase
CLH39_17865	COG0326	Molecular chaperone. Has ATPase activity
CLH39_17890	COG0583	DNA-binding transcription factor activity
CLH39_17900	COG0154	amidase activity
CLH39_17915	COG0477	Major facilitator Superfamily
CLH39_17925	COG4948	Mandelate Racemase Muconate Lactonizing
CLH39_17935	COG1418	mRNA catabolic process
CLH39_17945	COG1671	Belongs to the UPF0178 family
CLH39_17955	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CLH39_17960	COG0861	Integral membrane protein TerC family
CLH39_17985	COG0395	ABC-type sugar transport system, permease component
CLH39_18000	COG3842	ATPase activity
CLH39_18005	COG1349	DNA-binding transcription factor activity
CLH39_18030	COG1113	amino acid transport
CLH39_18035	COG3844	kynureninase activity
CLH39_18040	COG1522	sequence-specific DNA binding
CLH39_18045	COG1609	Transcriptional regulator
CLH39_18065	COG2186	Transcriptional regulator
CLH39_18070	COG1304	FMN binding
CLH39_18075	COG0277	FAD linked oxidase domain protein
CLH39_18080	COG1132	(ABC) transporter
CLH39_18080	COG2375	cellular response to nickel ion
CLH39_18085	COG1132	(ABC) transporter
CLH39_18090	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CLH39_18095	COG4605	iron ion homeostasis
CLH39_18100	COG4604	ABC transporter, ATP-binding protein
CLH39_18105	COG4607	ABC-type enterochelin transport system periplasmic component
CLH39_18110	COG4774	siderophore transport
CLH39_18125	COG0583	DNA-binding transcription factor activity
CLH39_18130	COG0655	NAD(P)H dehydrogenase (quinone) activity
CLH39_18135	COG2814	Major facilitator Superfamily
CLH39_18140	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CLH39_18165	COG3685	Protein conserved in bacteria
CLH39_18175	COG0583	DNA-binding transcription factor activity
CLH39_18180	COG2814	Major facilitator Superfamily
CLH39_18185	COG0656	L-ascorbic acid biosynthetic process
CLH39_18195	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
CLH39_18200	COG1196	nuclear chromosome segregation
CLH39_18290	COG0628	permease
CLH39_18295	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CLH39_18310	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
CLH39_18310	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CLH39_18320	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CLH39_18330	COG0129	dihydroxy-acid dehydratase activity
CLH39_18335	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
CLH39_18340	COG0730	response to heat
CLH39_18380	COG1950	PFAM Membrane protein of
CLH39_18385	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
CLH39_18390	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CLH39_18400	COG1560	Kdo2-lipid A biosynthetic process
CLH39_18405	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
CLH39_18415	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
CLH39_18420	COG0803	Belongs to the bacterial solute-binding protein 9 family
CLH39_18425	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CLH39_18435	COG0735	belongs to the Fur family
CLH39_18440	COG0523	cobalamin synthesis protein
CLH39_18450	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
CLH39_18455	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
CLH39_18470	COG2096	Adenosyltransferase
CLH39_18485	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CLH39_18500	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CLH39_18510	COG1280	lysine exporter protein (LysE YggA)
CLH39_18535	COG0251	oxidation-reduction process
CLH39_18550	COG1346	cytolysis
CLH39_18555	COG2860	membrane
CLH39_18560	COG2223	nitrite transmembrane transporter activity
CLH39_18570	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CLH39_18575	COG2197	response regulator
CLH39_18585	COG2918	glutathione biosynthetic process
CLH39_18615	COG1250	3-hydroxyacyl-CoA dehydrogenase
CLH39_18620	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CLH39_18630	COG1024	Enoyl-CoA hydratase
CLH39_18635	COG0067	glutamate synthase
CLH39_18635	COG0069	glutamate synthase activity
CLH39_18635	COG0070	glutamate synthase
CLH39_18655	COG0210	DNA helicase
CLH39_18660	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CLH39_18665	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
CLH39_18690	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CLH39_18700	COG3391	amine dehydrogenase activity
CLH39_18715	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CLH39_18725	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CLH39_18730	COG0765	amino acid transport
CLH39_18735	COG0765	amino acid transport
CLH39_18740	COG1126	abc transporter atp-binding protein
CLH39_18745	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CLH39_18750	COG0583	DNA-binding transcription factor activity
CLH39_18760	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
CLH39_18765	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CLH39_18770	COG0402	S-adenosylhomocysteine deaminase activity
CLH39_18785	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CLH39_18805	COG0456	acetyltransferase
CLH39_18815	COG1132	(ABC) transporter
CLH39_18825	COG2311	Membrane
CLH39_18840	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CLH39_18850	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CLH39_18875	COG1253	flavin adenine dinucleotide binding
CLH39_18885	COG0583	DNA-binding transcription factor activity
CLH39_18895	COG2814	Major facilitator Superfamily
CLH39_18900	COG0513	Belongs to the DEAD box helicase family
CLH39_18905	COG2819	hydrolase of the alpha beta superfamily
CLH39_18910	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CLH39_18915	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
CLH39_18935	COG1250	3-hydroxyacyl-CoA dehydrogenase
CLH39_18950	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CLH39_18965	COG0683	leucine binding
CLH39_18995	COG1021	2,3-dihydroxybenzoate-AMP ligase
CLH39_19000	COG3433	isochorismatase activity
CLH39_19000	COG1535	isochorismatase
CLH39_19005	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CLH39_19020	COG1169	isochorismate synthase
CLH39_19025	COG1535	isochorismatase
CLH39_19025	COG3433	isochorismatase activity
CLH39_19030	COG1028	Short-chain dehydrogenase reductase Sdr
CLH39_19040	COG0840	transmembrane signaling receptor activity
CLH39_19050	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CLH39_19055	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CLH39_19060	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
CLH39_19065	COG2967	ApaG domain
CLH39_19070	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CLH39_19080	COG0546	phosphoglycolate phosphatase activity
CLH39_19090	COG0512	Glutamine amidotransferase of anthranilate synthase
CLH39_19095	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CLH39_19100	COG0134	indole-3-glycerol-phosphate synthase activity
CLH39_19125	COG3154	lipid carrier protein
CLH39_19135	COG0826	peptidase U32
CLH39_19185	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
CLH39_19195	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
CLH39_19200	COG1024	Enoyl-CoA hydratase
CLH39_19205	COG0321	lipoyl(octanoyl) transferase activity
CLH39_19210	COG2921	Belongs to the UPF0250 family
CLH39_19220	COG1686	Belongs to the peptidase S11 family
CLH39_19230	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
CLH39_19230	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
CLH39_19235	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
CLH39_19240	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CLH39_19245	COG1278	Cold shock
CLH39_19255	COG0859	PFAM glycosyl transferase family 9
CLH39_19260	COG0583	DNA-binding transcription factor activity
CLH39_19265	COG4336	lyase activity
CLH39_19280	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CLH39_19295	COG0697	spore germination
CLH39_19300	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CLH39_19305	COG0242	peptide deformylase activity
CLH39_19310	COG0758	DNA mediated transformation
CLH39_19325	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CLH39_19350	COG0559	Belongs to the binding-protein-dependent transport system permease family
CLH39_19370	COG3181	Tripartite tricarboxylate transporter family receptor
CLH39_19375	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CLH39_19380	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CLH39_19405	COG0252	asparaginase activity
CLH39_19410	COG0564	pseudouridine synthase activity
CLH39_19420	COG2358	TRAP transporter, solute receptor (TAXI family
CLH39_19430	COG1254	Belongs to the acylphosphatase family
CLH39_19445	COG3093	addiction module antidote protein HigA
CLH39_19465	COG0583	DNA-binding transcription factor activity
CLH39_19505	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CLH39_19515	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CLH39_19520	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CLH39_19540	COG1127	ABC transporter
CLH39_19545	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CLH39_19575	COG0583	DNA-binding transcription factor activity
CLH39_19590	COG0154	amidase activity
CLH39_19605	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CLH39_19620	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
CLH39_19630	COG0513	Belongs to the DEAD box helicase family
CLH39_19635	COG1280	lysine exporter protein (LysE YggA)
CLH39_19640	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
CLH39_19660	COG0583	DNA-binding transcription factor activity
CLH39_19665	COG1335	isochorismatase
CLH39_19670	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
CLH39_19680	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
CLH39_19680	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CLH39_19685	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CLH39_19690	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CLH39_19695	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CLH39_19700	COG0066	3-isopropylmalate dehydratase activity
CLH39_19705	COG4774	siderophore transport
CLH39_19710	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
CLH39_19720	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CLH39_19760	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CLH39_19780	COG1960	acyl-CoA dehydrogenase activity
CLH39_19785	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
CLH39_19790	COG0183	Belongs to the thiolase family
CLH39_19795	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta