locus-tag	class	description
MID00_00010	COG1522	sequence-specific DNA binding
MID00_00025	COG2199	diguanylate cyclase activity
MID00_00075	COG3772	lysozyme
MID00_00085	COG0582	viral genome integration into host DNA
MID00_00200	COG2161	toxin-antitoxin pair type II binding
MID00_00205	COG4115	mRNA cleavage
MID00_00220	COG0501	Belongs to the peptidase M48B family
MID00_00230	COG0456	acetyltransferase
MID00_00245	COG1490	D-aminoacyl-tRNA deacylase activity
MID00_00250	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
MID00_00260	COG2239	Acts as a magnesium transporter
MID00_00265	COG2205	protein histidine kinase activity
MID00_00265	COG2198	Histidine kinase
MID00_00265	COG0784	Response regulator, receiver
MID00_00270	COG3437	response regulator, receiver
MID00_00275	COG1396	sequence-specific DNA binding
MID00_00290	COG0477	Major facilitator Superfamily
MID00_00295	COG3264	Mechanosensitive ion channel
MID00_00295	COG1196	nuclear chromosome segregation
MID00_00300	COG3264	Mechanosensitive ion channel
MID00_00300	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
MID00_00310	COG1028	Short-chain dehydrogenase reductase Sdr
MID00_00350	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
MID00_00355	COG1546	Belongs to the CinA family
MID00_00355	COG1058	Belongs to the CinA family
MID00_00360	COG1846	Transcriptional regulator
MID00_00370	COG0069	glutamate synthase activity
MID00_00385	COG1999	signal sequence binding
MID00_00405	COG2252	PERMEase
MID00_00410	COG1289	transmembrane transporter activity
MID00_00425	COG0025	NhaP-type Na H and K H
MID00_00450	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
MID00_00455	COG3258	Cytochrome c
MID00_00470	COG3278	Belongs to the heme-copper respiratory oxidase family
MID00_00480	COG0642	Histidine kinase
MID00_00485	COG1278	Cold shock
MID00_00515	COG0446	pyridine nucleotide-disulphide oxidoreductase
MID00_00555	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
MID00_00560	COG3755	Protein conserved in bacteria
MID00_00565	COG0583	DNA-binding transcription factor activity
MID00_00580	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
MID00_00585	COG1113	amino acid transport
MID00_00605	COG1858	cytochrome C peroxidase
MID00_00610	COG4771	TonB-dependent receptor
MID00_00625	COG2824	Alkylphosphonate utilization operon protein PhnA
MID00_00635	COG0583	DNA-binding transcription factor activity
MID00_00640	COG1028	Short-chain dehydrogenase reductase Sdr
MID00_00645	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
MID00_00650	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
MID00_00655	COG4521	taurine ABC transporter
MID00_00695	COG0582	viral genome integration into host DNA
MID00_00705	COG2610	gluconate transmembrane transporter activity
MID00_00710	COG1529	Aldehyde oxidase and xanthine dehydrogenase
MID00_00710	COG2010	Cytochrome c
MID00_00715	COG2080	2 iron, 2 sulfur cluster binding
MID00_00725	COG3181	Tripartite tricarboxylate transporter family receptor
MID00_00740	COG0840	transmembrane signaling receptor activity
MID00_00745	COG0840	transmembrane signaling receptor activity
MID00_00750	COG2733	membrane
MID00_00780	COG1191	sigma factor activity
MID00_00810	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
MID00_00815	COG1677	Flagellar hook-basal body complex protein FliE
MID00_00820	COG1766	The M ring may be actively involved in energy transduction
MID00_00835	COG1157	protein secretion by the type III secretion system
MID00_00850	COG1580	Controls the rotational direction of flagella during chemotaxis
MID00_00860	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
MID00_00875	COG1987	bacterial-type flagellum assembly
MID00_00885	COG2176	DNA-directed DNA polymerase activity
MID00_00910	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
MID00_00950	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
MID00_00955	COG1558	bacterial-type flagellum-dependent cell motility
MID00_00960	COG1815	bacterial-type flagellum-dependent cell motility
MID00_00985	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
MID00_00995	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
MID00_01000	COG0745	RESPONSE REGULATOR receiver
MID00_01010	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
MID00_01015	COG0840	transmembrane signaling receptor activity
MID00_01020	COG0835	chemotaxis
MID00_01030	COG1360	Flagellar Motor Protein
MID00_01050	COG0791	NLP P60 protein
MID00_01055	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
MID00_01060	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
MID00_01065	COG2314	TM2 domain
MID00_01075	COG1262	PFAM Formylglycine-generating sulfatase enzyme
MID00_01080	COG0659	secondary active sulfate transmembrane transporter activity
MID00_01105	COG0640	Transcriptional regulator
MID00_01115	COG3094	Invasion gene expression up-regulator, SirB
MID00_01135	COG0697	spore germination
MID00_01145	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
MID00_01160	COG1283	sodium-dependent phosphate transmembrane transporter activity
MID00_01165	COG0628	permease
MID00_01190	COG2207	Transcriptional regulator
MID00_01230	COG0477	Major facilitator Superfamily
MID00_01235	COG0583	DNA-binding transcription factor activity
MID00_01250	COG2159	amidohydrolase
MID00_01280	COG0247	lactate metabolic process
MID00_01285	COG0277	FAD linked oxidase domain protein
MID00_01290	COG0277	FAD linked oxidase domain protein
MID00_01295	COG2186	Transcriptional regulator
MID00_01345	COG1132	(ABC) transporter
MID00_01370	COG0438	transferase activity, transferring glycosyl groups
MID00_01385	COG0726	polysaccharide deacetylase
MID00_01390	COG0438	transferase activity, transferring glycosyl groups
MID00_01400	COG1643	Atp-dependent helicase
MID00_01405	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
MID00_01405	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
MID00_01410	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
MID00_01415	COG5001	Diguanylate cyclase
MID00_01415	COG4251	negative regulation of phosphorylation
MID00_01415	COG2203	Gaf domain
MID00_01415	COG3706	GGDEF domain
MID00_01420	COG0704	Plays a role in the regulation of phosphate uptake
MID00_01425	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
MID00_01430	COG1393	Belongs to the ArsC family
MID00_01435	COG1177	transmembrane transport
MID00_01440	COG1176	ABC-type spermidine putrescine transport system, permease component I
MID00_01445	COG3842	ATPase activity
MID00_01470	COG1028	Short-chain dehydrogenase reductase Sdr
MID00_01475	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
MID00_01480	COG1562	ergosterol biosynthetic process
MID00_01485	COG1562	ergosterol biosynthetic process
MID00_01490	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
MID00_01495	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MID00_01510	COG0436	Aminotransferase
MID00_01520	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
MID00_01525	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
MID00_01530	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
MID00_01540	COG0305	Participates in initiation and elongation during chromosome replication
MID00_01550	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
MID00_01555	COG2965	DNA replication, synthesis of RNA primer
MID00_01560	COG0360	Binds together with S18 to 16S ribosomal RNA
MID00_01565	COG1469	GTP cyclohydrolase I activity
MID00_01570	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
MID00_01575	COG0142	geranyltranstransferase activity
MID00_01580	COG1722	exodeoxyribonuclease VII activity
MID00_01600	COG0501	Belongs to the peptidase M48B family
MID00_01625	COG1283	sodium-dependent phosphate transmembrane transporter activity
MID00_01645	COG4215	(ABC) transporter
MID00_01650	COG4160	amino acid transport
MID00_01660	COG0446	pyridine nucleotide-disulphide oxidoreductase
MID00_01665	COG1217	gtp-binding protein TYPA
MID00_01670	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
MID00_01675	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
MID00_01685	COG2251	uridine kinase activity
MID00_01685	COG0195	Participates in both transcription termination and antitermination
MID00_01690	COG0779	Required for maturation of 30S ribosomal subunits
MID00_01695	COG1187	pseudouridine synthase activity
MID00_01700	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
MID00_01740	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
MID00_01745	COG1028	Short-chain dehydrogenase reductase Sdr
MID00_01750	COG3243	poly(R)-hydroxyalkanoic acid synthase
MID00_01760	COG0564	pseudouridine synthase activity
MID00_01775	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
MID00_01775	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
MID00_01785	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
MID00_01805	COG1199	ATP-dependent helicase activity
MID00_01810	COG2183	response to ionizing radiation
MID00_01830	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
MID00_01835	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MID00_01840	COG0508	dehydrogenase complex catalyzes the overall conversion of
MID00_01845	COG0567	Dehydrogenase, E1 component
MID00_01850	COG0281	malic enzyme
MID00_01850	COG0280	phosphate acetyltransferase
MID00_01860	COG0038	chloride channel
MID00_01865	COG1620	l-lactate permease
MID00_01870	COG2186	Transcriptional regulator
MID00_01875	COG0372	Belongs to the citrate synthase family
MID00_01880	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
MID00_01885	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
MID00_01890	COG1053	succinate dehydrogenase
MID00_01900	COG2009	succinate dehydrogenase
MID00_01905	COG2188	Transcriptional regulator
MID00_01910	COG0039	L-malate dehydrogenase activity
MID00_01920	COG0477	Major facilitator Superfamily
MID00_01925	COG3829	transcription factor binding
MID00_01955	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
MID00_01980	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
MID00_01985	COG1028	Short-chain dehydrogenase reductase Sdr
MID00_02015	COG1454	alcohol dehydrogenase
MID00_02020	COG1012	belongs to the aldehyde dehydrogenase family
MID00_02025	COG3284	Transcriptional regulator
MID00_02040	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MID00_02050	COG0747	negative chemotaxis
MID00_02065	COG1960	acyl-CoA dehydrogenase activity
MID00_02070	COG0598	Magnesium transport protein CorA
MID00_02075	COG2363	Small membrane protein
MID00_02080	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
MID00_02100	COG0655	NAD(P)H dehydrogenase (quinone) activity
MID00_02105	COG0435	Glutathione S-transferase
MID00_02110	COG1304	FMN binding
MID00_02140	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
MID00_02150	COG3842	ATPase activity
MID00_02155	COG4208	sulfate ABC transporter
MID00_02175	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
MID00_02190	COG0330	HflC and HflK could
MID00_02215	COG0037	tRNA processing
MID00_02220	COG0825	malonyl-CoA metabolic process
MID00_02230	COG0215	cysteine-tRNA ligase activity
MID00_02250	COG1968	undecaprenyl-diphosphatase activity
MID00_02255	COG1253	flavin adenine dinucleotide binding
MID00_02260	COG0483	inositol monophosphate 1-phosphatase activity
MID00_02275	COG2031	fatty acid transporter
MID00_02280	COG0154	amidase activity
MID00_02325	COG0668	transmembrane transport
MID00_02335	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MID00_02345	COG3181	Tripartite tricarboxylate transporter family receptor
MID00_02360	COG1132	(ABC) transporter
MID00_02365	COG0363	glucosamine-6-phosphate deaminase activity
MID00_02370	COG1538	Outer membrane efflux protein
MID00_02375	COG0577	efflux transmembrane transporter activity
MID00_02375	COG1136	(ABC) transporter
MID00_02380	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MID00_02390	COG3391	amine dehydrogenase activity
MID00_02410	COG0640	Transcriptional regulator
MID00_02415	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
MID00_02440	COG3846	protein secretion by the type IV secretion system
MID00_02450	COG3451	type IV secretory pathway VirB4
MID00_02460	COG3838	Conjugal transfer protein Trbc
MID00_02465	COG4962	Type ii secretion system protein e
MID00_02485	COG0583	DNA-binding transcription factor activity
MID00_02490	COG0815	Transfers the fatty acyl group on membrane lipoproteins
MID00_02505	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MID00_02510	COG0730	response to heat
MID00_02525	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MID00_02530	COG4232	protein-disulfide reductase activity
MID00_02535	COG0642	Histidine kinase
MID00_02560	COG3258	Cytochrome c
MID00_02565	COG2217	Heavy metal translocating P-type atpase
MID00_02570	COG3118	belongs to the thioredoxin family
MID00_02575	COG0492	ferredoxin-NADP+ reductase activity
MID00_02580	COG4133	protoheme IX ABC transporter activity
MID00_02585	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
MID00_02600	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
MID00_02610	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MID00_02615	COG3088	subunit of a heme lyase
MID00_02620	COG4235	cytochrome complex assembly
MID00_02635	COG4959	Type IV secretory pathway protease TraF
MID00_02650	COG1192	Involved in chromosome partitioning
MID00_02685	COG5489	Protein of unknown function (DUF736)
MID00_02695	COG2003	Belongs to the UPF0758 family
MID00_02730	COG0582	viral genome integration into host DNA
MID00_02740	COG2850	peptidyl-arginine hydroxylation
MID00_02745	COG3135	benzoate transporter
MID00_02750	COG2124	cytochrome p450
MID00_02755	COG0156	8-amino-7-oxononanoate synthase activity
MID00_02765	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
MID00_02780	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
MID00_02785	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
MID00_02790	COG1994	Peptidase M50
MID00_02795	COG0009	L-threonylcarbamoyladenylate synthase
MID00_02810	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
MID00_02815	COG3327	negative regulation of DNA-templated transcription, initiation
MID00_02820	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
MID00_02850	COG1368	sulfuric ester hydrolase activity
MID00_02860	COG2323	membrane
MID00_02865	COG2010	Cytochrome c
MID00_02870	COG1231	oxidoreductase activity
MID00_02920	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
MID00_02925	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
MID00_02945	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
MID00_02950	COG0248	Ppx GppA phosphatase
MID00_02960	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
MID00_02970	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MID00_02975	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
MID00_02980	COG1534	Rna-binding protein
MID00_02985	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
MID00_02990	COG2233	PERMEase
MID00_03010	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
MID00_03015	COG0505	Belongs to the CarA family
MID00_03020	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
MID00_03025	COG2226	methyltransferase
MID00_03030	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
MID00_03065	COG1074	ATP-dependent DNA helicase activity
MID00_03080	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
MID00_03085	COG4149	molybdate abc transporter
MID00_03090	COG0725	ABC transporter, periplasmic molybdate-binding protein
MID00_03095	COG4974	Belongs to the 'phage' integrase family
MID00_03100	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
MID00_03105	COG2223	nitrite transmembrane transporter activity
MID00_03115	COG2910	NAD(P)H-binding
MID00_03120	COG1733	regulation of RNA biosynthetic process
MID00_03145	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
MID00_03165	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
MID00_03170	COG1012	belongs to the aldehyde dehydrogenase family
MID00_03175	COG0583	DNA-binding transcription factor activity
MID00_03180	COG0280	phosphate acetyltransferase
MID00_03180	COG0281	malic enzyme
MID00_03185	COG3181	Tripartite tricarboxylate transporter family receptor
MID00_03195	COG0802	atpase or kinase
MID00_03200	COG0860	N-Acetylmuramoyl-L-alanine amidase
MID00_03205	COG0586	Pfam SNARE associated Golgi protein
MID00_03210	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
MID00_03215	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
MID00_03220	COG1953	Uracil, thiamine, allantoin
MID00_03225	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
MID00_03230	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
MID00_03240	COG0617	tRNA 3'-terminal CCA addition
MID00_03245	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
MID00_03250	COG1573	uracil-dna glycosylase
MID00_03265	COG2814	Major facilitator Superfamily
MID00_03275	COG1309	transcriptional regulator
MID00_03295	COG0752	glycyl-tRNA synthetase alpha subunit
MID00_03300	COG0751	glycine-tRNA ligase activity
MID00_03305	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
MID00_03310	COG0204	Acyl-transferase
MID00_03325	COG0700	Nucleoside recognition
MID00_03330	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
MID00_03335	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
MID00_03360	COG1126	abc transporter atp-binding protein
MID00_03365	COG0765	amino acid transport
MID00_03370	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MID00_03380	COG2011	ABC-type metal ion transport system permease component
MID00_03385	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
MID00_03400	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
MID00_03400	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
MID00_03410	COG0318	PFAM AMP-dependent synthetase and ligase
MID00_03415	COG1473	amidohydrolase
MID00_03425	COG2239	Acts as a magnesium transporter
MID00_03435	COG0653	protein targeting
MID00_03440	COG0739	heme binding
MID00_03440	COG0741	lytic transglycosylase activity
MID00_03440	COG1196	nuclear chromosome segregation
MID00_03450	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
MID00_03465	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
MID00_03470	COG1181	Belongs to the D-alanine--D-alanine ligase family
MID00_03475	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
MID00_03480	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
MID00_03490	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
MID00_03495	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
MID00_03500	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
MID00_03510	COG3116	cell division
MID00_03515	COG0275	rRNA processing
MID00_03520	COG2001	Belongs to the MraZ family
MID00_03530	COG0488	(ABC) transporter
MID00_03535	COG0633	Ferredoxin
MID00_03540	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
MID00_03545	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
MID00_03550	COG0514	ATP-dependent DNA helicase (RecQ)
MID00_03560	COG0038	chloride channel
MID00_03565	COG1294	oxidase, subunit
MID00_03570	COG1271	oxidase subunit
MID00_03575	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
MID00_03585	COG2894	cell division
MID00_03590	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
MID00_03610	COG0488	(ABC) transporter
MID00_03620	COG1215	transferase activity, transferring glycosyl groups
MID00_03625	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
MID00_03630	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
MID00_03640	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
MID00_03650	COG0259	pyridoxamine-phosphate oxidase activity
MID00_03655	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
MID00_03660	COG0579	oxidoreductase
MID00_03670	COG0405	Gamma-glutamyltransferase
MID00_03680	COG1960	acyl-CoA dehydrogenase activity
MID00_03685	COG1012	belongs to the aldehyde dehydrogenase family
MID00_03685	COG2030	dehydratase
MID00_03690	COG0596	Alpha beta hydrolase
MID00_03695	COG0009	L-threonylcarbamoyladenylate synthase
MID00_03700	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
MID00_03705	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
MID00_03710	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
MID00_03720	COG0521	Mo-molybdopterin cofactor biosynthetic process
MID00_03740	COG0126	phosphoglycerate kinase activity
MID00_03745	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
MID00_03750	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
MID00_03755	COG1385	rRNA (uridine-N3-)-methyltransferase activity
MID00_03760	COG2732	(Barnase) inhibitor
MID00_03770	COG0280	phosphate acetyltransferase
MID00_03770	COG0281	malic enzyme
MID00_03780	COG0436	Aminotransferase
MID00_03790	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
MID00_03805	COG0477	Major facilitator Superfamily
MID00_03815	COG0154	amidase activity
MID00_03830	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
MID00_03845	COG0583	DNA-binding transcription factor activity
MID00_03860	COG4575	ribosome binding
MID00_03870	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
MID00_03875	COG2027	D-alanyl-D-alanine carboxypeptidase
MID00_03880	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
MID00_03885	COG0343	queuine tRNA-ribosyltransferase activity
MID00_03890	COG1862	Preprotein translocase
MID00_03895	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
MID00_03900	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
MID00_03905	COG0024	Methionine aminopeptidase
MID00_03915	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
MID00_03920	COG1702	phosphate starvation-inducible protein PhoH
MID00_03925	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
MID00_03930	COG4535	Mg2 and Co2 transporter CorC
MID00_03935	COG0815	Transfers the fatty acyl group on membrane lipoproteins
MID00_03975	COG2814	Major facilitator Superfamily
MID00_04005	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
MID00_04010	COG0697	spore germination
MID00_04025	COG0678	peroxiredoxin activity
MID00_04055	COG0315	cyclic pyranopterin monophosphate synthase activity
MID00_04065	COG0314	molybdopterin synthase activity
MID00_04070	COG0521	Mo-molybdopterin cofactor biosynthetic process
MID00_04075	COG0303	'Molybdopterin
MID00_04085	COG0746	molybdenum cofactor guanylyltransferase activity
MID00_04090	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
MID00_04095	COG1910	domain protein
MID00_04110	COG3383	formate dehydrogenase (NAD+) activity
MID00_04115	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
MID00_04155	COG0463	Glycosyl transferase, family 2
MID00_04160	COG2346	COG2346, Truncated hemoglobins
MID00_04165	COG1959	2 iron, 2 sulfur cluster binding
MID00_04170	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
MID00_04175	COG1858	cytochrome C peroxidase
MID00_04185	COG0411	ABC transporter
MID00_04195	COG0559	Belongs to the binding-protein-dependent transport system permease family
MID00_04215	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
MID00_04215	COG2169	Transcriptional regulator
MID00_04225	COG0785	Cytochrome C biogenesis protein
MID00_04230	COG4235	cytochrome complex assembly
MID00_04235	COG3088	subunit of a heme lyase
MID00_04240	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MID00_04250	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
MID00_04260	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
MID00_04280	COG0583	DNA-binding transcription factor activity
MID00_04285	COG0288	reversible hydration of carbon dioxide
MID00_04300	COG0488	(ABC) transporter
MID00_04330	COG0012	GTP binding
MID00_04340	COG0193	aminoacyl-tRNA hydrolase activity
MID00_04345	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
MID00_04350	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
MID00_04365	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
MID00_04375	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
MID00_04385	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
MID00_04395	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
MID00_04400	COG0179	Fumarylacetoacetate (FAA) hydrolase
MID00_04410	COG0277	FAD linked oxidase domain protein
MID00_04420	COG0438	transferase activity, transferring glycosyl groups
MID00_04425	COG0438	transferase activity, transferring glycosyl groups
MID00_04430	COG0438	transferase activity, transferring glycosyl groups
MID00_04445	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
MID00_04450	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
MID00_04460	COG3195	allantoin biosynthetic process
MID00_04460	COG3648	Uricase
MID00_04465	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
MID00_04470	COG0235	Class ii aldolase
MID00_04475	COG1942	4-Oxalocrotonate Tautomerase
MID00_04480	COG2233	PERMEase
MID00_04490	COG0583	DNA-binding transcription factor activity
MID00_04495	COG3960	tartronate-semialdehyde synthase activity
MID00_04500	COG3622	Belongs to the hyi family
MID00_04505	COG2084	Dehydrogenase
MID00_04515	COG3193	protein, possibly involved in utilization of glycolate and propanediol
MID00_04520	COG0469	pyruvate kinase activity
MID00_04525	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
MID00_04550	COG3278	Belongs to the heme-copper respiratory oxidase family
MID00_04555	COG1765	OsmC-like protein
MID00_04560	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
MID00_04570	COG0509	glycine decarboxylation via glycine cleavage system
MID00_04575	COG2081	HI0933 family
MID00_04600	COG0489	protein tyrosine kinase activity
MID00_04610	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MID00_04610	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MID00_04615	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
MID00_04620	COG0583	DNA-binding transcription factor activity
MID00_04625	COG3257	ureidoglycine aminohydrolase activity
MID00_04630	COG0590	tRNA wobble adenosine to inosine editing
MID00_04635	COG3391	amine dehydrogenase activity
MID00_04650	COG0235	Class ii aldolase
MID00_04655	COG0477	Major facilitator Superfamily
MID00_04670	COG0387	Pfam Sodium calcium exchanger
MID00_04680	COG0583	DNA-binding transcription factor activity
MID00_04705	COG3433	isochorismatase activity
MID00_04705	COG1535	isochorismatase
MID00_04720	COG0583	DNA-binding transcription factor activity
MID00_04725	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
MID00_04755	COG0640	Transcriptional regulator
MID00_04760	COG0450	alkyl hydroperoxide reductase
MID00_04765	COG0723	plastoquinol--plastocyanin reductase activity
MID00_04790	COG0500	methyltransferase
MID00_04800	COG0640	Transcriptional regulator
MID00_04810	COG4988	ABC transporter
MID00_04815	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
MID00_04825	COG1294	oxidase, subunit
MID00_04835	COG2814	Major facilitator Superfamily
MID00_04850	COG0640	Transcriptional regulator
MID00_04875	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MID00_04890	COG0583	DNA-binding transcription factor activity
MID00_04895	COG1028	Short-chain dehydrogenase reductase Sdr
MID00_04910	COG1309	transcriptional regulator
MID00_04920	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MID00_04925	COG1131	(ABC) transporter
MID00_04930	COG0842	Transport permease protein
MID00_04935	COG0842	Transport permease protein
MID00_04950	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
MID00_04955	COG1611	Belongs to the LOG family
MID00_04975	COG0583	DNA-binding transcription factor activity
MID00_05035	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
MID00_05200	COG2003	Belongs to the UPF0758 family
MID00_05275	COG0582	viral genome integration into host DNA
MID00_05285	COG0220	tRNA (guanine-N7-)-methyltransferase activity
MID00_05300	COG1652	LysM domain
MID00_05305	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
MID00_05320	COG3023	N-Acetylmuramoyl-L-alanine amidase
MID00_05330	COG3128	pkhd-type hydroxylase
MID00_05335	COG4774	siderophore transport
MID00_05340	COG0326	Molecular chaperone. Has ATPase activity
MID00_05365	COG0583	DNA-binding transcription factor activity
MID00_05375	COG0154	amidase activity
MID00_05390	COG0477	Major facilitator Superfamily
MID00_05400	COG4948	Mandelate Racemase Muconate Lactonizing
MID00_05410	COG1418	mRNA catabolic process
MID00_05420	COG1671	Belongs to the UPF0178 family
MID00_05430	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
MID00_05435	COG0861	Integral membrane protein TerC family
MID00_05460	COG0395	ABC-type sugar transport system, permease component
MID00_05480	COG1349	DNA-binding transcription factor activity
MID00_05485	COG3181	Tripartite tricarboxylate transporter family receptor
MID00_05515	COG1113	amino acid transport
MID00_05520	COG3844	kynureninase activity
MID00_05525	COG1522	sequence-specific DNA binding
MID00_05530	COG1609	Transcriptional regulator
MID00_05550	COG2186	Transcriptional regulator
MID00_05555	COG1304	FMN binding
MID00_05560	COG0277	FAD linked oxidase domain protein
MID00_05565	COG1132	(ABC) transporter
MID00_05565	COG2375	cellular response to nickel ion
MID00_05570	COG1132	(ABC) transporter
MID00_05575	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MID00_05580	COG4605	iron ion homeostasis
MID00_05585	COG4604	ABC transporter, ATP-binding protein
MID00_05590	COG4607	ABC-type enterochelin transport system periplasmic component
MID00_05595	COG4774	siderophore transport
MID00_05615	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MID00_05630	COG1846	Transcriptional regulator
MID00_05650	COG3685	Protein conserved in bacteria
MID00_05660	COG0583	DNA-binding transcription factor activity
MID00_05665	COG2814	Major facilitator Superfamily
MID00_05670	COG0656	L-ascorbic acid biosynthetic process
MID00_05675	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
MID00_05700	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
MID00_05740	COG2003	Belongs to the UPF0758 family
MID00_05745	COG5377	YqaJ viral recombinase family
MID00_05770	COG0582	viral genome integration into host DNA
MID00_05780	COG0628	permease
MID00_05790	COG3181	Tripartite tricarboxylate transporter family receptor
MID00_05810	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
MID00_05825	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
MID00_05825	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
MID00_05835	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
MID00_05845	COG0129	dihydroxy-acid dehydratase activity
MID00_05850	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
MID00_05855	COG0730	response to heat
MID00_05860	COG0275	rRNA processing
MID00_05895	COG1950	PFAM Membrane protein of
MID00_05900	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
MID00_05905	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
MID00_05915	COG1560	Kdo2-lipid A biosynthetic process
MID00_05920	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
MID00_05930	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
MID00_05935	COG0803	Belongs to the bacterial solute-binding protein 9 family
MID00_05940	COG1108	ABC-type Mn2 Zn2 transport systems permease components
MID00_05950	COG0735	belongs to the Fur family
MID00_05955	COG0523	cobalamin synthesis protein
MID00_05965	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
MID00_05970	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
MID00_05985	COG2096	Adenosyltransferase
MID00_06000	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
MID00_06015	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
MID00_06025	COG1280	lysine exporter protein (LysE YggA)
MID00_06065	COG0251	oxidation-reduction process
MID00_06080	COG1346	cytolysis
MID00_06085	COG2860	membrane
MID00_06090	COG2223	nitrite transmembrane transporter activity
MID00_06100	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
MID00_06115	COG2918	glutathione biosynthetic process
MID00_06145	COG2271	Major facilitator Superfamily
MID00_06175	COG1012	belongs to the aldehyde dehydrogenase family
MID00_06180	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
MID00_06190	COG1028	Short-chain dehydrogenase reductase Sdr
MID00_06195	COG1414	Transcriptional regulator
MID00_06210	COG1028	Short-chain dehydrogenase reductase Sdr
MID00_06215	COG1250	3-hydroxyacyl-CoA dehydrogenase
MID00_06220	COG1804	L-carnitine dehydratase bile acid-inducible protein F
MID00_06230	COG1024	Enoyl-CoA hydratase
MID00_06235	COG0070	glutamate synthase
MID00_06235	COG0069	glutamate synthase activity
MID00_06235	COG0067	glutamate synthase
MID00_06250	COG0210	DNA helicase
MID00_06255	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
MID00_06260	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
MID00_06285	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
MID00_06295	COG3391	amine dehydrogenase activity
MID00_06310	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
MID00_06320	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
MID00_06325	COG0765	amino acid transport
MID00_06330	COG0765	amino acid transport
MID00_06335	COG1126	abc transporter atp-binding protein
MID00_06340	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MID00_06345	COG0583	DNA-binding transcription factor activity
MID00_06355	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
MID00_06360	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
MID00_06365	COG0402	S-adenosylhomocysteine deaminase activity
MID00_06380	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
MID00_06400	COG0456	acetyltransferase
MID00_06415	COG2311	Membrane
MID00_06430	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
MID00_06465	COG1253	flavin adenine dinucleotide binding
MID00_06475	COG0583	DNA-binding transcription factor activity
MID00_06485	COG2814	Major facilitator Superfamily
MID00_06490	COG0513	Belongs to the DEAD box helicase family
MID00_06500	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MID00_06505	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
MID00_06525	COG1250	3-hydroxyacyl-CoA dehydrogenase
MID00_06540	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
MID00_06555	COG0683	leucine binding
MID00_06585	COG1021	2,3-dihydroxybenzoate-AMP ligase
MID00_06590	COG3433	isochorismatase activity
MID00_06590	COG1535	isochorismatase
MID00_06595	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
MID00_06610	COG1169	isochorismate synthase
MID00_06615	COG1535	isochorismatase
MID00_06615	COG3433	isochorismatase activity
MID00_06620	COG1028	Short-chain dehydrogenase reductase Sdr
MID00_06630	COG0840	transmembrane signaling receptor activity
MID00_06640	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
MID00_06645	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
MID00_06650	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
MID00_06655	COG2967	ApaG domain
MID00_06660	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
MID00_06670	COG0546	phosphoglycolate phosphatase activity
MID00_06680	COG0512	Glutamine amidotransferase of anthranilate synthase
MID00_06685	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
MID00_06690	COG0134	indole-3-glycerol-phosphate synthase activity
MID00_06715	COG3154	lipid carrier protein
MID00_06725	COG0826	peptidase U32
MID00_06770	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
MID00_06780	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
MID00_06785	COG1024	Enoyl-CoA hydratase
MID00_06790	COG0321	lipoyl(octanoyl) transferase activity
MID00_06795	COG2921	Belongs to the UPF0250 family
MID00_06805	COG1686	Belongs to the peptidase S11 family
MID00_06815	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
MID00_06815	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
MID00_06820	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
MID00_06825	COG1210	Utp--glucose-1-phosphate uridylyltransferase
MID00_06830	COG1278	Cold shock
MID00_06840	COG0859	PFAM glycosyl transferase family 9
MID00_06845	COG0583	DNA-binding transcription factor activity
MID00_06850	COG4336	lyase activity
MID00_06880	COG0697	spore germination
MID00_06885	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
MID00_06890	COG0242	peptide deformylase activity
MID00_06895	COG0758	DNA mediated transformation
MID00_06910	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MID00_06935	COG0559	Belongs to the binding-protein-dependent transport system permease family
MID00_06955	COG3181	Tripartite tricarboxylate transporter family receptor
MID00_06960	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
MID00_06965	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
MID00_06990	COG0252	asparaginase activity
MID00_06995	COG0564	pseudouridine synthase activity
MID00_07005	COG2358	TRAP transporter, solute receptor (TAXI family
MID00_07015	COG1254	Belongs to the acylphosphatase family
MID00_07030	COG3093	addiction module antidote protein HigA
MID00_07050	COG0583	DNA-binding transcription factor activity
MID00_07075	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
MID00_07085	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
MID00_07090	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
MID00_07110	COG1127	ABC transporter
MID00_07115	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
MID00_07145	COG0583	DNA-binding transcription factor activity
MID00_07160	COG0154	amidase activity
MID00_07175	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
MID00_07190	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
MID00_07200	COG0513	Belongs to the DEAD box helicase family
MID00_07205	COG1280	lysine exporter protein (LysE YggA)
MID00_07210	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
MID00_07230	COG0583	DNA-binding transcription factor activity
MID00_07235	COG1335	isochorismatase
MID00_07240	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
MID00_07250	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
MID00_07250	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
MID00_07255	COG1804	L-carnitine dehydratase bile acid-inducible protein F
MID00_07260	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
MID00_07265	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
MID00_07270	COG0066	3-isopropylmalate dehydratase activity
MID00_07275	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
MID00_07290	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
MID00_07315	COG0018	arginyl-trna synthetase
MID00_07325	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
MID00_07355	COG1960	acyl-CoA dehydrogenase activity
MID00_07360	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
MID00_07365	COG0183	Belongs to the thiolase family
MID00_07370	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
MID00_07385	COG2922	Belongs to the Smg family
MID00_07415	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
MID00_07420	COG0028	Belongs to the TPP enzyme family
MID00_07440	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
MID00_07450	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
MID00_07455	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
MID00_07465	COG4149	molybdate abc transporter
MID00_07490	COG0431	NADPH-dependent FMN reductase
MID00_07495	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MID00_07515	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
MID00_07525	COG1464	Belongs to the NlpA lipoprotein family
MID00_07550	COG2011	ABC-type metal ion transport system permease component
MID00_07555	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
MID00_07560	COG1464	Belongs to the NlpA lipoprotein family
MID00_07565	COG1464	Belongs to the NlpA lipoprotein family
MID00_07570	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
MID00_07575	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
MID00_07585	COG0601	transmembrane transport
MID00_07590	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MID00_07595	COG0444	Belongs to the ABC transporter superfamily
MID00_07600	COG4608	Belongs to the ABC transporter superfamily
MID00_07605	COG1595	DNA-templated transcription, initiation
MID00_07635	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
MID00_07650	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
MID00_07660	COG1028	Short-chain dehydrogenase reductase Sdr
MID00_07730	COG4638	Rieske (2fe-2S)
MID00_07740	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
MID00_07745	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
MID00_07750	COG0179	Fumarylacetoacetate (FAA) hydrolase
MID00_07770	COG1846	Transcriptional regulator
MID00_07825	COG0523	cobalamin synthesis protein
MID00_07835	COG0436	Aminotransferase
MID00_07845	COG3842	ATPase activity
MID00_07855	COG0583	DNA-binding transcription factor activity
MID00_07860	COG0697	spore germination
MID00_07870	COG3181	Tripartite tricarboxylate transporter family receptor
MID00_07885	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MID00_07890	COG0508	dehydrogenase complex catalyzes the overall conversion of
MID00_07890	COG0596	Alpha beta hydrolase
MID00_07900	COG0318	PFAM AMP-dependent synthetase and ligase
MID00_07915	COG0559	Belongs to the binding-protein-dependent transport system permease family
MID00_07935	COG2271	Major facilitator Superfamily
MID00_07940	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
MID00_07945	COG1802	Transcriptional regulator
MID00_07960	COG1187	pseudouridine synthase activity
MID00_07970	COG0592	DNA-directed DNA polymerase activity
MID00_07975	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
MID00_07980	COG0230	Belongs to the bacterial ribosomal protein bL34 family
MID00_07985	COG0594	ribonuclease P activity
MID00_07990	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
MID00_07995	COG0706	membrane insertase activity
MID00_08000	COG0753	catalase activity
MID00_08035	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
MID00_08040	COG3645	SOS response
MID00_08080	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
MID00_08090	COG0688	phosphatidylethanolamine metabolic process
MID00_08095	COG3706	GGDEF domain
MID00_08100	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
MID00_08110	COG0436	Aminotransferase
MID00_08115	COG0445	tRNA wobble uridine modification
MID00_08120	COG0357	Ribosomal RNA small subunit methyltransferase G
MID00_08125	COG1192	Involved in chromosome partitioning
MID00_08130	COG1475	DNA binding
MID00_08155	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
MID00_08180	COG0081	regulation of translation
MID00_08185	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
MID00_08190	COG0222	ribosome binding
MID00_08195	COG0085	RNA polymerase activity
MID00_08200	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
MID00_08205	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
MID00_08235	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
MID00_08240	COG0049	tRNA binding
MID00_08245	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
MID00_08250	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
MID00_08255	COG0051	transcription antitermination factor activity, RNA binding
MID00_08260	COG4176	ABC-type proline glycine betaine transport system permease component
MID00_08265	COG4175	Glycine betaine
MID00_08270	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
MID00_08275	COG0088	Forms part of the polypeptide exit tunnel
MID00_08280	COG0089	rRNA binding
MID00_08285	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
MID00_08290	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
MID00_08295	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
MID00_08300	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
MID00_08305	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
MID00_08310	COG0255	Belongs to the universal ribosomal protein uL29 family
MID00_08315	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
MID00_08330	COG1960	acyl-CoA dehydrogenase activity
MID00_08335	COG1116	anion transmembrane transporter activity
MID00_08350	COG1648	precorrin-2 dehydrogenase activity
MID00_08350	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
MID00_08355	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
MID00_08360	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
MID00_08365	COG0318	PFAM AMP-dependent synthetase and ligase
MID00_08380	COG2067	long-chain fatty acid transport protein
MID00_08390	COG0183	Belongs to the thiolase family
MID00_08410	COG1538	Outer membrane efflux protein
MID00_08455	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
MID00_08460	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
MID00_08465	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
MID00_08470	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
MID00_08475	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
MID00_08480	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
MID00_08485	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
MID00_08490	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
MID00_08495	COG1841	ribosomal large subunit assembly
MID00_08500	COG0200	Binds to the 23S rRNA
MID00_08505	COG0201	protein transport
MID00_08515	COG0257	Belongs to the bacterial ribosomal protein bL36 family
MID00_08520	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
MID00_08525	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
MID00_08530	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
MID00_08535	COG0202	RNA polymerase activity
MID00_08540	COG0203	ribosomal protein L17
MID00_08545	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MID00_08565	COG4232	protein-disulfide reductase activity
MID00_08570	COG0113	porphobilinogen synthase activity
MID00_08575	COG0218	Necessary for normal cell division and for the maintenance of normal septation
MID00_08585	COG1333	cytochrome c biogenesis protein
MID00_08590	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
MID00_08595	COG5001	Diguanylate cyclase
MID00_08595	COG5002	protein histidine kinase activity
MID00_08615	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
MID00_08620	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
MID00_08625	COG0232	Belongs to the dGTPase family. Type 2 subfamily
MID00_08635	COG2814	Major facilitator Superfamily
MID00_08645	COG2186	Transcriptional regulator
MID00_08650	COG0179	Fumarylacetoacetate (FAA) hydrolase
MID00_08655	COG3181	Tripartite tricarboxylate transporter family receptor
MID00_08660	COG0251	oxidation-reduction process
MID00_08665	COG2814	Major facilitator Superfamily
MID00_08680	COG2814	Major facilitator Superfamily
MID00_08690	COG1802	Transcriptional regulator
MID00_08700	COG3069	C4-dicarboxylate transmembrane transporter activity
MID00_08750	COG2423	ornithine cyclodeaminase activity
MID00_08770	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
MID00_08775	COG2365	Tyrosine phosphatase family
MID00_08795	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
MID00_08795	COG1017	nitric oxide dioxygenase activity
MID00_08805	COG0789	Transcriptional regulator
MID00_08815	COG0583	DNA-binding transcription factor activity
MID00_08820	COG0477	Major facilitator Superfamily
MID00_08840	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
MID00_08845	COG2986	histidine ammonia-lyase
MID00_08865	COG1228	amidohydrolase
MID00_08875	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MID00_08900	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
MID00_08905	COG3568	Endonuclease Exonuclease Phosphatase
MID00_08920	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
MID00_08925	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
MID00_08945	COG0109	protoheme IX farnesyltransferase activity
MID00_08985	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
MID00_09005	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
MID00_09010	COG0438	transferase activity, transferring glycosyl groups
MID00_09015	COG1522	sequence-specific DNA binding
MID00_09025	COG1595	DNA-templated transcription, initiation
MID00_09060	COG0583	DNA-binding transcription factor activity
MID00_09065	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
MID00_09095	COG3284	Transcriptional regulator
MID00_09105	COG2823	Periplasmic or secreted lipoprotein
MID00_09125	COG1335	isochorismatase
MID00_09135	COG1028	Short-chain dehydrogenase reductase Sdr
MID00_09140	COG0477	Major facilitator Superfamily
MID00_09145	COG0583	DNA-binding transcription factor activity
MID00_09150	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
MID00_09175	COG2226	methyltransferase
MID00_09180	COG3706	GGDEF domain
MID00_09185	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
MID00_09195	COG0656	L-ascorbic acid biosynthetic process
MID00_09200	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
MID00_09220	COG3483	tryptophan 2,3-dioxygenase activity
MID00_09230	COG1522	sequence-specific DNA binding
MID00_09235	COG1802	Transcriptional regulator
MID00_09240	COG0129	dihydroxy-acid dehydratase activity
MID00_09245	COG2084	Dehydrogenase
MID00_09255	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
MID00_09260	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
MID00_09280	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
MID00_09300	COG4150	thiosulfate binding
MID00_09305	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
MID00_09310	COG4208	sulfate ABC transporter
MID00_09315	COG2969	positive regulation of protein catabolic process
MID00_09320	COG0625	glutathione transferase activity
MID00_09325	COG2857	Cytochrome c1
MID00_09330	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
MID00_09335	COG0723	plastoquinol--plastocyanin reductase activity
MID00_09340	COG1970	mechanosensitive ion channel activity
MID00_09350	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MID00_09360	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
MID00_09365	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
MID00_09370	COG0537	adenosine 5'-monophosphoramidase activity
MID00_09375	COG0140	phosphoribosyl-ATP diphosphatase activity
MID00_09385	COG0107	imidazoleglycerol-phosphate synthase activity
MID00_09390	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
MID00_09400	COG0131	Imidazoleglycerol-phosphate dehydratase
MID00_09405	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
MID00_09415	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
MID00_09425	COG0842	Transport permease protein
MID00_09430	COG1131	(ABC) transporter
MID00_09445	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
MID00_09450	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
MID00_09455	COG1127	ABC transporter
MID00_09470	COG1024	Enoyl-CoA hydratase
MID00_09470	COG1250	3-hydroxyacyl-CoA dehydrogenase
MID00_09475	COG0183	Belongs to the thiolase family
MID00_09570	COG2885	chlorophyll binding
MID00_09590	COG0697	spore germination
MID00_09595	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MID00_09600	COG0697	spore germination
MID00_09605	COG2233	PERMEase
MID00_09610	COG0604	alcohol dehydrogenase
MID00_09610	COG3321	synthase
MID00_09615	COG3321	synthase
MID00_09615	COG1028	Short-chain dehydrogenase reductase Sdr
MID00_09615	COG0604	alcohol dehydrogenase
MID00_09620	COG0156	8-amino-7-oxononanoate synthase activity
MID00_09655	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
MID00_09680	COG0297	glycogen (starch) synthase activity
MID00_09690	COG1215	transferase activity, transferring glycosyl groups
MID00_09715	COG0166	Belongs to the GPI family
MID00_09730	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
MID00_09745	COG4263	nitrous-oxide reductase activity
MID00_09750	COG0348	domain, Protein
MID00_09750	COG3901	Regulator of nitric oxide reductase transcription
MID00_09755	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
MID00_09760	COG0709	Synthesizes selenophosphate from selenide and ATP
MID00_09770	COG4771	TonB-dependent receptor
MID00_09780	COG3181	Tripartite tricarboxylate transporter family receptor
MID00_09795	COG1476	TRANSCRIPTIONal
MID00_09805	COG3276	selenocysteine insertion sequence binding
MID00_09810	COG1921	L-seryl-tRNASec selenium transferase activity
MID00_09820	COG2864	formate dehydrogenase
MID00_09825	COG0437	4 iron, 4 sulfur cluster binding
MID00_09840	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
MID00_09845	COG0477	Major facilitator Superfamily
MID00_09860	COG5002	protein histidine kinase activity
MID00_09880	COG3180	Ammonia monooxygenase
MID00_09895	COG2264	protein methyltransferase activity
MID00_09900	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
MID00_09915	COG0811	peptide transport
MID00_09945	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
MID00_09995	COG2890	protein-(glutamine-N5) methyltransferase activity
MID00_10000	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
MID00_10005	COG0163	prenyltransferase activity
MID00_10010	COG0037	tRNA processing
MID00_10025	COG1024	Enoyl-CoA hydratase
MID00_10035	COG0356	it plays a direct role in the translocation of protons across the membrane
MID00_10050	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
MID00_10055	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
MID00_10060	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
MID00_10070	COG0355	proton-transporting ATP synthase activity, rotational mechanism
MID00_10085	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
MID00_10090	COG1088	dTDP-glucose 4,6-dehydratase activity
MID00_10140	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
MID00_10155	COG3473	Maleate cis-trans isomerase
MID00_10160	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
MID00_10170	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
MID00_10190	COG2204	response regulator
MID00_10205	COG0745	RESPONSE REGULATOR receiver
MID00_10210	COG4771	TonB-dependent receptor
MID00_10215	COG2226	methyltransferase
MID00_10220	COG1040	competence protein
MID00_10225	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
MID00_10230	COG3181	Tripartite tricarboxylate transporter family receptor
MID00_10235	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
MID00_10240	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
MID00_10250	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
MID00_10255	COG0588	phosphoglycerate mutase activity
MID00_10265	COG0793	Belongs to the peptidase S41A family
MID00_10270	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
MID00_10290	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
MID00_10305	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
MID00_10310	COG0792	nuclease activity
MID00_10315	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
MID00_10320	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
MID00_10325	COG1660	Displays ATPase and GTPase activities
MID00_10330	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
MID00_10335	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
MID00_10345	COG1137	ATPase activity
MID00_10360	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
MID00_10375	COG1271	oxidase subunit
MID00_10380	COG1294	oxidase, subunit
MID00_10390	COG4988	ABC transporter
MID00_10395	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
MID00_10425	COG1238	metal cluster binding
MID00_10430	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
MID00_10435	COG1984	allophanate hydrolase subunit 2
MID00_10440	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
MID00_10450	COG5002	protein histidine kinase activity
MID00_10455	COG0745	RESPONSE REGULATOR receiver
MID00_10460	COG2226	methyltransferase
MID00_10475	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
MID00_10485	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
MID00_10490	COG1538	Outer membrane efflux protein
MID00_10495	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
MID00_10500	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
MID00_10505	COG0351	phosphomethylpyrimidine kinase
MID00_10510	COG2022	thiamine diphosphate biosynthetic process
MID00_10525	COG0598	Magnesium transport protein CorA
MID00_10545	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
MID00_10555	COG1595	DNA-templated transcription, initiation
MID00_10570	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
MID00_10575	COG4206	TonB-dependent receptor
MID00_10610	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
MID00_10625	COG0259	pyridoxamine-phosphate oxidase activity
MID00_10630	COG0477	Major facilitator Superfamily
MID00_10640	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
MID00_10645	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
MID00_10660	COG0237	dephospho-CoA kinase activity
MID00_10665	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
MID00_10690	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
MID00_10695	COG0494	nUDIX hydrolase
MID00_10705	COG0142	geranyltranstransferase activity
MID00_10710	COG0786	glutamate:sodium symporter activity
MID00_10715	COG1090	epimerase
MID00_10725	COG3046	protein related to deoxyribodipyrimidine photolyase
MID00_10750	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
MID00_10765	COG1309	transcriptional regulator
MID00_10785	COG3604	Transcriptional regulator
MID00_10795	COG1024	Enoyl-CoA hydratase
MID00_10810	COG1960	acyl-CoA dehydrogenase activity
MID00_10815	COG1846	Transcriptional regulator
MID00_10835	COG3384	dioxygenase
MID00_10840	COG2259	Doxx family
MID00_10845	COG0583	DNA-binding transcription factor activity
MID00_10850	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
MID00_10855	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
MID00_10860	COG0154	amidase activity
MID00_10865	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
MID00_10870	COG1077	Cell shape determining protein MreB Mrl
MID00_10875	COG1792	Involved in formation and maintenance of cell shape
MID00_10885	COG0768	penicillin binding
MID00_10890	COG0772	Belongs to the SEDS family
MID00_10900	COG2177	Part of the ABC transporter FtsEX involved in
MID00_10905	COG2884	Cell division ATP-binding protein ftsE
MID00_10910	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MID00_10915	COG4597	amino acid ABC transporter
MID00_10920	COG0765	amino acid transport
MID00_10925	COG1126	abc transporter atp-binding protein
MID00_10940	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
MID00_10965	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
MID00_10970	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
MID00_10975	COG0211	Belongs to the bacterial ribosomal protein bL27 family
MID00_10980	COG0261	This protein binds to 23S rRNA in the presence of protein L20
MID00_10985	COG3237	CsbD-like
MID00_10995	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
MID00_11010	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
MID00_11015	COG0352	thiamine-phosphate diphosphorylase activity
MID00_11030	COG1678	Uncharacterized ACR, COG1678
MID00_11045	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
MID00_11055	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
MID00_11060	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
MID00_11075	COG3150	esterase
MID00_11080	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
MID00_11085	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MID00_11090	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
MID00_11095	COG0511	ligase activity, forming carbon-carbon bonds
MID00_11100	COG0439	Biotin carboxylase
MID00_11115	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MID00_11120	COG3133	Outer membrane lipoprotein
MID00_11125	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
MID00_11125	COG2169	Transcriptional regulator
MID00_11130	COG0762	integral membrane protein
MID00_11160	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
MID00_11165	COG4566	intracellular signal transduction
MID00_11170	COG0745	RESPONSE REGULATOR receiver
MID00_11170	COG4191	Histidine kinase
MID00_11170	COG2205	protein histidine kinase activity
MID00_11200	COG3028	Belongs to the UPF0307 family
MID00_11205	COG0312	modulator of DNA gyrase
MID00_11210	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
MID00_11215	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
MID00_11220	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
MID00_11225	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
MID00_11235	COG0316	Belongs to the HesB IscA family
MID00_11240	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
MID00_11245	COG0739	heme binding
MID00_11250	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
MID00_11255	COG1881	PFAM PEBP family protein
MID00_11260	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
MID00_11265	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
MID00_11270	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
MID00_11270	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
MID00_11310	COG0642	Histidine kinase
MID00_11315	COG0745	RESPONSE REGULATOR receiver
MID00_11320	COG0431	NADPH-dependent FMN reductase
MID00_11325	COG1393	Belongs to the ArsC family
MID00_11360	COG0583	DNA-binding transcription factor activity
MID00_11370	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
MID00_11380	COG1454	alcohol dehydrogenase
MID00_11385	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
MID00_11390	COG0583	DNA-binding transcription factor activity
MID00_11450	COG0583	DNA-binding transcription factor activity
MID00_11455	COG1902	pentaerythritol trinitrate reductase activity
MID00_11460	COG0604	alcohol dehydrogenase
MID00_11480	COG1024	Enoyl-CoA hydratase
MID00_11490	COG0604	alcohol dehydrogenase
MID00_11525	COG1877	trehalose-phosphatase activity
MID00_11530	COG1028	Short-chain dehydrogenase reductase Sdr
MID00_11545	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
MID00_11565	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
MID00_11590	COG1054	Belongs to the UPF0176 family
MID00_11600	COG1301	dicarboxylic acid transport
MID00_11605	COG4191	Histidine kinase
MID00_11610	COG2204	response regulator
MID00_11620	COG1388	LysM domain
MID00_11620	COG0741	lytic transglycosylase activity
MID00_11625	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MID00_11630	COG2226	methyltransferase
MID00_11635	COG0328	RNA-DNA hybrid ribonuclease activity
MID00_11640	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MID00_11645	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
MID00_11660	COG2031	fatty acid transporter
MID00_11665	COG4206	TonB-dependent receptor
MID00_11675	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MID00_11680	COG1120	ATPase activity
MID00_11695	COG0596	Alpha beta hydrolase
MID00_11700	COG2309	aminopeptidase activity
MID00_11705	COG1335	isochorismatase
MID00_11730	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
MID00_11755	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
MID00_11760	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
MID00_11770	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
MID00_11775	COG3608	succinylglutamate desuccinylase aspartoacylase
MID00_11775	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
MID00_11780	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
MID00_11780	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
MID00_11790	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
MID00_11800	COG2188	Transcriptional regulator
MID00_11805	COG1234	tRNA 3'-trailer cleavage
MID00_11820	COG3181	Tripartite tricarboxylate transporter family receptor
MID00_11835	COG3706	GGDEF domain
MID00_11860	COG0411	ABC transporter
MID00_11865	COG0410	ABC transporter
MID00_11875	COG2010	Cytochrome c
MID00_11875	COG1529	Aldehyde oxidase and xanthine dehydrogenase
MID00_11880	COG2080	2 iron, 2 sulfur cluster binding
MID00_11885	COG2010	Cytochrome c
MID00_11885	COG1529	Aldehyde oxidase and xanthine dehydrogenase
MID00_11890	COG0596	Alpha beta hydrolase
MID00_11895	COG2309	aminopeptidase activity
MID00_11900	COG1335	isochorismatase
MID00_11925	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
MID00_11955	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
MID00_11960	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
MID00_11965	COG0742	ribosomal rna small subunit methyltransferase
MID00_11990	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
MID00_11995	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
MID00_12000	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
MID00_12005	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
MID00_12015	COG1414	Transcriptional regulator
MID00_12030	COG0284	orotidine-5'-phosphate decarboxylase activity
MID00_12035	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
MID00_12045	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
MID00_12060	COG0154	amidase activity
MID00_12065	COG3706	GGDEF domain
MID00_12075	COG1741	Belongs to the pirin family
MID00_12080	COG0583	DNA-binding transcription factor activity
MID00_12095	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
MID00_12105	COG5383	Protein conserved in bacteria
MID00_12110	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
MID00_12115	COG1012	belongs to the aldehyde dehydrogenase family
MID00_12135	COG0175	sulfate reduction
MID00_12140	COG0697	spore germination
MID00_12155	COG3634	alkyl hydroperoxide reductase activity
MID00_12160	COG0583	DNA-binding transcription factor activity
MID00_12165	COG0427	acetyl-CoA hydrolase
MID00_12185	COG3845	ABC transporter
MID00_12190	COG4603	Belongs to the binding-protein-dependent transport system permease family
MID00_12195	COG1079	Belongs to the binding-protein-dependent transport system permease family
MID00_12220	COG0596	Alpha beta hydrolase
MID00_12235	COG0823	Involved in the tonB-independent uptake of proteins
MID00_12250	COG0811	peptide transport
MID00_12255	COG0824	Thioesterase
MID00_12260	COG0442	prolyl-tRNA aminoacylation
MID00_12265	COG0494	nUDIX hydrolase
MID00_12280	COG2084	Dehydrogenase
MID00_12285	COG1840	ABC-type Fe3 transport system, periplasmic component
MID00_12290	COG3842	ATPase activity
MID00_12295	COG1177	transmembrane transport
MID00_12335	COG4654	Cytochrome c, class I
MID00_12340	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
MID00_12405	COG0415	Belongs to the DNA photolyase family
MID00_12415	COG0418	dihydroorotase activity
MID00_12425	COG2255	four-way junction helicase activity
MID00_12435	COG0632	four-way junction helicase activity
MID00_12440	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
MID00_12450	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
MID00_12460	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
MID00_12485	COG0429	hydrolase of the alpha beta-hydrolase fold
MID00_12505	COG0513	Belongs to the DEAD box helicase family
MID00_12525	COG1414	Transcriptional regulator
MID00_12545	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
MID00_12550	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
MID00_12565	COG1846	Transcriptional regulator
MID00_12570	COG1027	Aspartate ammonia-lyase
MID00_12585	COG0516	GMP reductase activity
MID00_12585	COG0517	IMP dehydrogenase activity
MID00_12650	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
MID00_12700	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
MID00_12720	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MID00_12725	COG3278	Belongs to the heme-copper respiratory oxidase family
MID00_12770	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
MID00_12780	COG0789	Transcriptional regulator
MID00_12790	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
MID00_12795	COG0505	Belongs to the CarA family
MID00_12810	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
MID00_12825	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
MID00_12840	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
MID00_12845	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
MID00_12855	COG3243	poly(R)-hydroxyalkanoic acid synthase
MID00_12860	COG1538	Outer membrane efflux protein
MID00_12865	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MID00_12870	COG0842	Transport permease protein
MID00_12870	COG1129	ABC transporter
MID00_12875	COG0842	Transport permease protein
MID00_12885	COG1028	Short-chain dehydrogenase reductase Sdr
MID00_12920	COG2814	Major facilitator Superfamily
MID00_12925	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MID00_12930	COG0154	amidase activity
MID00_12950	COG2197	response regulator
MID00_12955	COG2205	protein histidine kinase activity
MID00_12955	COG0784	Response regulator, receiver
MID00_12960	COG2205	protein histidine kinase activity
MID00_12960	COG0784	Response regulator, receiver
MID00_12970	COG3121	Chaperone
MID00_12990	COG2814	Major facilitator Superfamily
MID00_13000	COG4569	acetaldehyde dehydrogenase (acetylating) activity
MID00_13005	COG3971	2-oxopent-4-enoate hydratase activity
MID00_13020	COG0446	pyridine nucleotide-disulphide oxidoreductase
MID00_13035	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
MID00_13040	COG4638	Rieske (2fe-2S)
MID00_13045	COG0583	DNA-binding transcription factor activity
MID00_13055	COG0513	Belongs to the DEAD box helicase family
MID00_13060	COG1414	Transcriptional regulator
MID00_13095	COG1454	alcohol dehydrogenase
MID00_13110	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
MID00_13115	COG2819	hydrolase of the alpha beta superfamily
MID00_13125	COG2814	Major facilitator Superfamily
MID00_13185	COG1538	Outer membrane efflux protein
MID00_13245	COG0629	single-stranded DNA binding
MID00_13250	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
MID00_13255	COG0270	DNA (cytosine-5-)-methyltransferase activity
MID00_13290	COG0772	Belongs to the SEDS family
MID00_13460	COG2003	Belongs to the UPF0758 family
MID00_13510	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
MID00_13510	COG2111	Na H antiporter
MID00_13515	COG2111	Na H antiporter
MID00_13520	COG1006	Multisubunit Na H antiporter MnhC subunit
MID00_13525	COG0651	ATP synthesis coupled electron transport
MID00_13530	COG1863	multisubunit Na H antiporter MnhE subunit
MID00_13540	COG1320	monovalent cation:proton antiporter activity
MID00_13545	COG3852	Histidine kinase
MID00_13550	COG2204	response regulator
MID00_13555	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
MID00_13560	COG0583	DNA-binding transcription factor activity
MID00_13575	COG0582	viral genome integration into host DNA
MID00_13595	COG0812	UDP-N-acetylmuramate dehydrogenase activity
MID00_13605	COG0477	Major facilitator Superfamily
MID00_13615	COG2267	carboxylic ester hydrolase activity
MID00_13630	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
MID00_13635	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
MID00_13640	COG0735	belongs to the Fur family
MID00_13645	COG0497	DNA recombination
MID00_13655	COG1420	regulation of RNA biosynthetic process
MID00_13660	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
MID00_13665	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
MID00_13670	COG0443	Heat shock 70 kDa protein
MID00_13675	COG0484	heat shock protein binding
MID00_13680	COG0612	Peptidase, M16
MID00_13740	COG4964	Belongs to the GSP D family
MID00_13780	COG2204	response regulator
MID00_13800	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MID00_13825	COG1960	acyl-CoA dehydrogenase activity
MID00_13830	COG2272	Belongs to the type-B carboxylesterase lipase family
MID00_13850	COG0477	Major facilitator Superfamily
MID00_13870	COG0492	ferredoxin-NADP+ reductase activity
MID00_13875	COG1674	ftsk spoiiie
MID00_13880	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
MID00_13885	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
MID00_13890	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
MID00_13910	COG1028	Short-chain dehydrogenase reductase Sdr
MID00_13915	COG3022	response to hydroperoxide
MID00_13920	COG1289	transmembrane transporter activity
MID00_13925	COG0028	Belongs to the TPP enzyme family
MID00_13930	COG0440	acetolactate synthase activity
MID00_13935	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
MID00_13940	COG1183	phosphatidylcholine synthase activity
MID00_13945	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
MID00_13950	COG1185	polyribonucleotide nucleotidyltransferase activity
MID00_13965	COG0604	alcohol dehydrogenase
MID00_13970	COG0149	triose-phosphate isomerase activity
MID00_13985	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
MID00_13990	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MID00_13995	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MID00_14000	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MID00_14005	COG0649	NAD binding
MID00_14020	COG1034	ATP synthesis coupled electron transport
MID00_14025	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
MID00_14030	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MID00_14040	COG0713	ATP synthesis coupled electron transport
MID00_14055	COG1007	ATP synthesis coupled electron transport
MID00_14070	COG0560	Phosphoserine phosphatase
MID00_14075	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
MID00_14080	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
MID00_14085	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
MID00_14100	COG1214	PFAM Peptidase M22, glycoprotease
MID00_14105	COG1573	uracil-dna glycosylase
MID00_14115	COG1196	nuclear chromosome segregation
MID00_14125	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
MID00_14130	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
MID00_14140	COG2917	probably involved in intracellular septation
MID00_14145	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
MID00_14170	COG3047	cAMP biosynthetic process
MID00_14175	COG1129	ABC transporter
MID00_14180	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
MID00_14185	COG2878	Part of a membrane complex involved in electron transport
MID00_14195	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
MID00_14200	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
MID00_14210	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
MID00_14215	COG0133	tryptophan synthase activity
MID00_14220	COG0159	tryptophan synthase activity
MID00_14225	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
MID00_14230	COG1530	ribonuclease E activity
MID00_14235	COG0564	pseudouridine synthase activity
MID00_14240	COG0546	phosphoglycolate phosphatase activity
MID00_14245	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
MID00_14250	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
MID00_14255	COG3023	N-Acetylmuramoyl-L-alanine amidase
MID00_14265	COG0424	maF-like protein
MID00_14270	COG1399	metal-binding, possibly nucleic acid-binding protein
MID00_14275	COG0333	Belongs to the bacterial ribosomal protein bL32 family
MID00_14285	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
MID00_14290	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
MID00_14295	COG1028	Short-chain dehydrogenase reductase Sdr
MID00_14300	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
MID00_14305	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
MID00_14330	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MID00_14345	COG0571	ribonuclease III activity
MID00_14350	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
MID00_14355	COG1381	Involved in DNA repair and RecF pathway recombination
MID00_14370	COG1045	serine acetyltransferase
MID00_14385	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
MID00_14395	COG0583	DNA-binding transcription factor activity
MID00_14405	COG0583	DNA-binding transcription factor activity
MID00_14415	COG0791	NLP P60 protein
MID00_14425	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
MID00_14460	COG0504	CTP synthase activity
MID00_14470	COG2877	3-deoxy-8-phosphooctulonate synthase activity
MID00_14485	COG2814	Major facilitator Superfamily
MID00_14495	COG0148	phosphopyruvate hydratase activity
MID00_14500	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
MID00_14510	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
MID00_14525	COG1981	membrane
MID00_14530	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
MID00_14535	COG1466	dna polymerase III delta subunit
MID00_14545	COG0495	leucyl-tRNA aminoacylation
MID00_14550	COG0267	Belongs to the bacterial ribosomal protein bL33 family
MID00_14555	COG0227	Belongs to the bacterial ribosomal protein bL28 family
MID00_14560	COG2814	Major facilitator Superfamily
MID00_14565	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
MID00_14575	COG4176	ABC-type proline glycine betaine transport system permease component
MID00_14580	COG4175	Glycine betaine
MID00_14585	COG0534	Mate efflux family protein
MID00_14615	COG0477	Major facilitator Superfamily
MID00_14620	COG1737	Transcriptional regulator
MID00_14625	COG2003	Belongs to the UPF0758 family
MID00_14630	COG1047	Peptidyl-prolyl cis-trans
MID00_14635	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
MID00_14640	COG0625	glutathione transferase activity
MID00_14645	COG2084	Dehydrogenase
MID00_14655	COG0023	Translation Initiation Factor
MID00_14675	COG0424	maF-like protein
MID00_14680	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
MID00_14685	COG0799	negative regulation of ribosome biogenesis
MID00_14690	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
MID00_14700	COG0151	Belongs to the GarS family
MID00_14705	COG0217	transcriptional regulatory protein
MID00_14710	COG0433	COG0433 Predicted ATPase
MID00_14715	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
MID00_14720	COG0473	3-isopropylmalate dehydrogenase activity
MID00_14735	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
MID00_14740	COG0308	aminopeptidase N
MID00_14755	COG0312	modulator of DNA gyrase
MID00_14765	COG1846	Transcriptional regulator
MID00_14770	COG0456	acetyltransferase
MID00_14780	COG0662	Cupin 2, conserved barrel domain protein
MID00_14785	COG5285	phytanoyl-CoA dioxygenase
MID00_14795	COG1126	abc transporter atp-binding protein
MID00_14800	COG0765	amino acid transport
MID00_14805	COG0765	amino acid transport
MID00_14810	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MID00_14815	COG1966	Carbon starvation protein
MID00_14820	COG2879	small protein
MID00_14825	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
MID00_14830	COG0277	FAD linked oxidase domain protein
MID00_14835	COG0482	sulfurtransferase activity
MID00_14840	COG0730	response to heat
MID00_14845	COG0657	acetylesterase activity
MID00_14855	COG0625	glutathione transferase activity
MID00_14865	COG3909	cytochrome
MID00_14870	COG0004	ammonium transporteR
MID00_14875	COG0347	Belongs to the P(II) protein family
MID00_14880	COG1846	Transcriptional regulator
MID00_14885	COG2175	clavaminate synthase activity
MID00_14890	COG2271	Major facilitator Superfamily
MID00_14900	COG2321	neutral zinc metallopeptidase
MID00_14905	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
MID00_14920	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
MID00_14925	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
MID00_14940	COG2119	membrane
MID00_14945	COG0840	transmembrane signaling receptor activity
MID00_14960	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
MID00_14965	COG2046	Belongs to the sulfate adenylyltransferase family
MID00_14970	COG2198	Histidine kinase
MID00_14970	COG2205	protein histidine kinase activity
MID00_14970	COG0784	Response regulator, receiver
MID00_14980	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
MID00_15000	COG1280	lysine exporter protein (LysE YggA)
MID00_15005	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
MID00_15015	COG0625	glutathione transferase activity
MID00_15050	COG0488	(ABC) transporter
MID00_15060	COG1309	transcriptional regulator
MID00_15065	COG0251	oxidation-reduction process
MID00_15075	COG0436	Aminotransferase
MID00_15085	COG4335	DNA alkylation repair
MID00_15090	COG1408	metallophosphoesterase
MID00_15095	COG0753	catalase activity
MID00_15115	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
MID00_15125	COG0583	DNA-binding transcription factor activity
MID00_15135	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
MID00_15150	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
MID00_15160	COG0287	Prephenate dehydrogenase
MID00_15165	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
MID00_15170	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
MID00_15190	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
MID00_15195	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
MID00_15200	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
MID00_15215	COG2951	lytic endotransglycosylase activity
MID00_15220	COG0123	including yeast histone deacetylase and acetoin utilization protein
MID00_15235	COG1960	acyl-CoA dehydrogenase activity
MID00_15240	COG0450	alkyl hydroperoxide reductase
MID00_15260	COG0335	large ribosomal subunit rRNA binding
MID00_15270	COG1162	GTPase activity
MID00_15275	COG0501	Belongs to the peptidase M48B family
MID00_15280	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
MID00_15285	COG3396	Phenylacetate-CoA oxygenase
MID00_15290	COG3460	Phenylacetate-CoA oxygenase
MID00_15295	COG3396	Phenylacetate-CoA oxygenase
MID00_15300	COG2151	metal-sulfur cluster biosynthetic enzyme
MID00_15305	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
MID00_15310	COG1012	belongs to the aldehyde dehydrogenase family
MID00_15315	COG1024	Enoyl-CoA hydratase
MID00_15320	COG2050	protein possibly involved in aromatic compounds catabolism
MID00_15330	COG0736	holo-[acyl-carrier-protein] synthase activity
MID00_15335	COG1472	Belongs to the glycosyl hydrolase 3 family
MID00_15355	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
MID00_15355	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
MID00_15360	COG2224	Isocitrate lyase
MID00_15365	COG2217	Heavy metal translocating P-type atpase
MID00_15375	COG3278	Belongs to the heme-copper respiratory oxidase family
MID00_15395	COG0348	domain, Protein
MID00_15410	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
MID00_15415	COG0542	response to heat
MID00_15420	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
MID00_15425	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
MID00_15440	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
MID00_15445	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
MID00_15470	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
MID00_15510	COG2351	hydroxyisourate hydrolase activity
MID00_15525	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
MID00_15530	COG0425	Belongs to the sulfur carrier protein TusA family
MID00_15535	COG0228	four-way junction DNA binding
MID00_15545	COG0336	Belongs to the RNA methyltransferase TrmD family
MID00_15555	COG0583	DNA-binding transcription factor activity
MID00_15565	COG0105	UTP biosynthetic process
MID00_15570	COG0820	rRNA (adenine-C2-)-methyltransferase activity
MID00_15585	COG0124	histidyl-tRNA synthetase
MID00_15590	COG2976	Protein conserved in bacteria
MID00_15595	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
MID00_15600	COG1160	GTP binding
MID00_15610	COG1923	regulation of RNA biosynthetic process
MID00_15615	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
MID00_15620	COG0330	HflC and HflK could
MID00_15625	COG0330	HflC and HflK could
MID00_15635	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
MID00_15640	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
MID00_15645	COG0828	Belongs to the bacterial ribosomal protein bS21 family
MID00_15660	COG2205	protein histidine kinase activity
MID00_15665	COG0745	RESPONSE REGULATOR receiver
MID00_15675	COG0402	S-adenosylhomocysteine deaminase activity
MID00_15685	COG1529	Aldehyde oxidase and xanthine dehydrogenase
MID00_15710	COG3135	benzoate transporter
MID00_15715	COG2207	Transcriptional regulator
MID00_15720	COG2807	transmembrane transport
MID00_15725	COG2814	Major facilitator Superfamily
MID00_15730	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
MID00_15740	COG1741	Belongs to the pirin family
MID00_15750	COG0625	glutathione transferase activity
MID00_15755	COG3530	Putative quorum-sensing-regulated virulence factor
MID00_15760	COG0412	Dienelactone hydrolase
MID00_15780	COG1840	ABC-type Fe3 transport system, periplasmic component
MID00_15785	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
MID00_15795	COG3842	ATPase activity
MID00_15800	COG0583	DNA-binding transcription factor activity
MID00_15830	COG2375	cellular response to nickel ion
MID00_15870	COG0557	exoribonuclease II activity
MID00_15875	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
MID00_15880	COG0626	cystathionine gamma-synthase activity
MID00_15885	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MID00_15890	COG2010	Cytochrome c
MID00_15900	COG1648	precorrin-2 dehydrogenase activity
MID00_15900	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
MID00_15905	COG0535	radical SAM domain protein
MID00_15920	COG1522	sequence-specific DNA binding
MID00_15925	COG3391	amine dehydrogenase activity
MID00_15935	COG1648	precorrin-2 dehydrogenase activity
MID00_15935	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
MID00_15950	COG1278	Cold shock
MID00_15970	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
MID00_15975	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
MID00_15980	COG4208	sulfate ABC transporter
MID00_15985	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
MID00_16010	COG0642	Histidine kinase
MID00_16015	COG3158	transport of potassium into the cell
MID00_16030	COG2212	antiporter activity
MID00_16040	COG0651	ATP synthesis coupled electron transport
MID00_16045	COG1006	Multisubunit Na H antiporter MnhC subunit
MID00_16050	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
MID00_16050	COG2111	Na H antiporter
MID00_16060	COG2070	2-Nitropropane dioxygenase
MID00_16075	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
MID00_16090	COG0540	Belongs to the ATCase OTCase family
MID00_16105	COG3162	membrane
MID00_16110	COG1024	Enoyl-CoA hydratase
MID00_16115	COG0318	PFAM AMP-dependent synthetase and ligase
MID00_16130	COG0477	Major facilitator Superfamily
MID00_16145	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
MID00_16150	COG2137	regulation of response to DNA damage stimulus
MID00_16155	COG0583	DNA-binding transcription factor activity
MID00_16160	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
MID00_16170	COG0045	succinate-CoA ligase (ADP-forming) activity
MID00_16175	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
MID00_16180	COG0861	Integral membrane protein TerC family
MID00_16185	COG0181	hydroxymethylbilane synthase activity
MID00_16195	COG2959	enzyme of heme biosynthesis
MID00_16275	COG0625	glutathione transferase activity
MID00_16295	COG2003	Belongs to the UPF0758 family
MID00_16350	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
MID00_16380	COG1475	DNA binding
MID00_16405	COG5489	Protein of unknown function (DUF736)
MID00_16460	COG3609	addiction module antidote protein, CC2985 family
MID00_16485	COG0583	DNA-binding transcription factor activity
MID00_16500	COG4962	Type ii secretion system protein e
MID00_16515	COG3451	type IV secretory pathway VirB4
MID00_16545	COG2948	multi-organism process
MID00_16630	COG4964	Belongs to the GSP D family
MID00_16660	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
MID00_16665	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
MID00_16675	COG1295	ribonuclease BN
MID00_16685	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
MID00_16690	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
MID00_16705	COG4566	intracellular signal transduction
MID00_16715	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
MID00_16735	COG0473	3-isopropylmalate dehydrogenase activity
MID00_16740	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
MID00_16750	COG0101	tRNA pseudouridine synthase activity
MID00_16760	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
MID00_16765	COG0135	phosphoribosylanthranilate isomerase activity
MID00_16770	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MID00_16785	COG2207	Transcriptional regulator
MID00_16790	COG0519	Catalyzes the synthesis of GMP from XMP
MID00_16790	COG0518	GMP synthase (glutamine-hydrolyzing) activity
MID00_16795	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
MID00_16800	COG0318	PFAM AMP-dependent synthetase and ligase
MID00_16805	COG1666	GTP binding
MID00_16815	COG0842	Transport permease protein
MID00_16820	COG1131	(ABC) transporter
MID00_16825	COG0590	tRNA wobble adenosine to inosine editing
MID00_16830	COG1619	proteins homologs of microcin C7 resistance protein MccF
MID00_16835	COG0488	(ABC) transporter
MID00_16855	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MID00_16860	COG2252	PERMEase
MID00_16865	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
MID00_16870	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
MID00_16875	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
MID00_16880	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
MID00_16890	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
MID00_16900	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
MID00_16925	COG4974	Belongs to the 'phage' integrase family
MID00_16935	COG0165	Argininosuccinate lyase
MID00_16940	COG0668	transmembrane transport
MID00_16950	COG0656	L-ascorbic acid biosynthetic process
MID00_16955	COG2814	Major facilitator Superfamily
MID00_16960	COG3161	chorismate lyase activity
MID00_16965	COG1187	pseudouridine synthase activity
MID00_16970	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
MID00_16975	COG0584	glycerophosphoryl diester phosphodiesterase
MID00_16980	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
MID00_16985	COG0739	heme binding
MID00_16990	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
MID00_17000	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
MID00_17005	COG1758	RNA polymerase activity
MID00_17010	COG0194	GDP metabolic process
MID00_17045	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
MID00_17055	COG0183	Belongs to the thiolase family
MID00_17060	COG0183	Belongs to the thiolase family
MID00_17080	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
MID00_17085	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MID00_17090	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
MID00_17100	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
MID00_17120	COG0640	Transcriptional regulator
MID00_17125	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
MID00_17140	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
MID00_17145	COG4566	intracellular signal transduction
MID00_17155	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
MID00_17160	COG0508	dehydrogenase complex catalyzes the overall conversion of
MID00_17165	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MID00_17170	COG0285	dihydrofolate synthase activity
MID00_17180	COG1286	toxin biosynthetic process
MID00_17205	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
MID00_17210	COG0024	Methionine aminopeptidase
MID00_17215	COG0052	Belongs to the universal ribosomal protein uS2 family
MID00_17220	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
MID00_17225	COG0528	UMP kinase activity
MID00_17230	COG0233	cytoplasmic translational termination
MID00_17235	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
MID00_17240	COG0575	Belongs to the CDS family
MID00_17245	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
MID00_17255	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
MID00_17265	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
MID00_17270	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
MID00_17280	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
MID00_17285	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
MID00_17290	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
MID00_17315	COG1252	NADH dehydrogenase
MID00_17320	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
MID00_17325	COG2867	negative regulation of translational initiation
MID00_17330	COG2914	Belongs to the UPF0125 (RnfH) family
MID00_17335	COG1960	acyl-CoA dehydrogenase activity
MID00_17350	COG0354	folic acid binding
MID00_17355	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
MID00_17365	COG0470	DNA polymerase III
MID00_17370	COG0084	hydrolase, TatD family'
MID00_17400	COG0625	glutathione transferase activity
MID00_17405	COG1393	Belongs to the ArsC family
MID00_17410	COG2353	YceI-like domain
MID00_17420	COG3038	cytochrome b561
MID00_17450	COG1028	Short-chain dehydrogenase reductase Sdr
MID00_17455	COG2894	cell division
MID00_17500	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
MID00_17515	COG3039	Transposase
MID00_17525	COG3122	Protein conserved in bacteria
MID00_17590	COG2003	Belongs to the UPF0758 family
MID00_17620	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
MID00_17625	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
MID00_17725	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
MID00_17740	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
MID00_17755	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
MID00_17765	COG3586	endonuclease activity
MID00_17910	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
MID00_17915	COG2132	Multicopper oxidase
MID00_17925	COG4974	Belongs to the 'phage' integrase family
MID00_17930	COG0583	DNA-binding transcription factor activity
MID00_17965	COG0583	DNA-binding transcription factor activity
MID00_17975	COG2807	transmembrane transport
MID00_17985	COG0589	response to stress
MID00_17990	COG2133	pyrroloquinoline quinone binding
MID00_17995	COG0114	fumarate hydratase activity
MID00_18005	COG1028	Short-chain dehydrogenase reductase Sdr
MID00_18010	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
MID00_18020	COG0625	glutathione transferase activity
MID00_18040	COG0559	Belongs to the binding-protein-dependent transport system permease family
MID00_18055	COG1653	transport
MID00_18060	COG1175	transmembrane transport
MID00_18065	COG0395	ABC-type sugar transport system, permease component
MID00_18070	COG3842	ATPase activity
MID00_18080	COG0783	Belongs to the Dps family
MID00_18090	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
MID00_18105	COG1840	ABC-type Fe3 transport system, periplasmic component
MID00_18110	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
MID00_18115	COG3842	ATPase activity
MID00_18135	COG2153	protein acetylation
MID00_18140	COG0174	glutamine synthetase
MID00_18145	COG0635	Involved in the biosynthesis of porphyrin-containing compound
MID00_18150	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
MID00_18155	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
MID00_18170	COG1561	YicC-like family, N-terminal region
MID00_18175	COG2816	NAD+ diphosphatase activity
MID00_18205	COG2814	Major facilitator Superfamily
MID00_18215	COG1473	amidohydrolase
MID00_18220	COG0071	Belongs to the small heat shock protein (HSP20) family
MID00_18225	COG2233	PERMEase
MID00_18265	COG1660	Displays ATPase and GTPase activities
MID00_18270	COG0307	riboflavin synthase, alpha
MID00_18280	COG4221	oxidoreductase activity
MID00_18285	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MID00_18290	COG1028	Short-chain dehydrogenase reductase Sdr
MID00_18300	COG1360	Flagellar Motor Protein
MID00_18315	COG1686	Belongs to the peptidase S11 family
MID00_18320	COG0583	DNA-binding transcription factor activity
MID00_18360	COG0587	DNA-directed DNA polymerase activity
MID00_18365	COG1610	YqeY-like protein
MID00_18375	COG1902	pentaerythritol trinitrate reductase activity
MID00_18380	COG0569	domain protein
MID00_18385	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
MID00_18400	COG1262	PFAM Formylglycine-generating sulfatase enzyme
MID00_18410	COG3949	Membrane
MID00_18420	COG3048	D-serine ammonia-lyase activity
MID00_18425	COG2207	Transcriptional regulator
MID00_18475	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
MID00_18485	COG4172	Belongs to the ABC transporter superfamily
MID00_18490	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MID00_18495	COG0601	transmembrane transport
MID00_18500	COG0747	negative chemotaxis
MID00_18530	COG0457	Tetratricopeptide repeat
MID00_18535	COG1649	PFAM Uncharacterised BCR, COG1649
MID00_18535	COG0726	polysaccharide deacetylase
MID00_18540	COG1215	transferase activity, transferring glycosyl groups
MID00_18575	COG2151	metal-sulfur cluster biosynthetic enzyme
MID00_18580	COG0822	iron-sulfur transferase activity
MID00_18590	COG0719	Fe-S assembly protein
MID00_18595	COG0396	ATPase activity
MID00_18600	COG0719	Fe-S assembly protein
MID00_18605	COG1959	2 iron, 2 sulfur cluster binding
MID00_18610	COG5265	(ABC) transporter
MID00_18625	COG2833	Protein of unknown function (DUF455)
MID00_18640	COG0072	phenylalanine-tRNA ligase activity
MID00_18640	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MID00_18645	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
MID00_18650	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
MID00_18655	COG0291	Belongs to the bacterial ribosomal protein bL35 family
MID00_18695	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
MID00_18700	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
MID00_18715	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
MID00_18720	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
MID00_18740	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MID00_18750	COG3042	response to heat
MID00_18765	COG1585	Membrane protein implicated in regulation of membrane protease activity
MID00_18770	COG0330	HflC and HflK could
MID00_18795	COG0402	S-adenosylhomocysteine deaminase activity
MID00_18805	COG1609	Transcriptional regulator
MID00_18815	COG1280	lysine exporter protein (LysE YggA)
MID00_18820	COG2814	Major facilitator Superfamily
MID00_18850	COG2871	sodium ion transport
MID00_18900	COG1126	abc transporter atp-binding protein
MID00_18905	COG0765	amino acid transport
MID00_18910	COG0765	amino acid transport
MID00_18915	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MID00_18940	COG3422	double-strand break repair
MID00_18945	COG1272	protein, Hemolysin III
MID00_18965	COG0667	Aldo Keto reductase
MID00_18970	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
MID00_18975	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
MID00_19000	COG0697	spore germination
MID00_19010	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
MID00_19020	COG2271	Major facilitator Superfamily
MID00_19025	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
MID00_19030	COG1846	Transcriptional regulator
MID00_19055	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
MID00_19060	COG2197	response regulator
MID00_19070	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
MID00_19080	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
MID00_19085	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
MID00_19090	COG3135	benzoate transporter
MID00_19100	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
MID00_19105	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
MID00_19115	COG3485	protocatechuate 3,4-dioxygenase
MID00_19140	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
MID00_19165	COG0640	Transcriptional regulator
MID00_19190	COG1960	acyl-CoA dehydrogenase activity
MID00_19200	COG1804	L-carnitine dehydratase bile acid-inducible protein F
MID00_19250	COG0740	serine-type endopeptidase activity
MID00_19255	COG0625	glutathione transferase activity
MID00_19295	COG2070	2-Nitropropane dioxygenase
MID00_19310	COG1942	4-Oxalocrotonate Tautomerase
MID00_19320	COG0351	phosphomethylpyrimidine kinase
MID00_19325	COG0745	RESPONSE REGULATOR receiver
MID00_19345	COG1078	dGTPase activity
MID00_19365	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
MID00_19370	COG0735	belongs to the Fur family
MID00_19375	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
MID00_19385	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
MID00_19390	COG1469	GTP cyclohydrolase I activity
MID00_19395	COG0523	cobalamin synthesis protein
MID00_19400	COG2378	regulation of single-species biofilm formation
MID00_19410	COG1960	acyl-CoA dehydrogenase activity
MID00_19420	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
MID00_19435	COG0583	DNA-binding transcription factor activity
MID00_19445	COG0519	Catalyzes the synthesis of GMP from XMP
MID00_19445	COG0518	GMP synthase (glutamine-hydrolyzing) activity
MID00_19470	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
MID00_19470	COG0047	phosphoribosylformylglycinamidine synthase activity
MID00_19480	COG0613	PHP domain protein
MID00_19495	COG0084	hydrolase, TatD family'
MID00_19500	COG1136	(ABC) transporter
MID00_19515	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
MID00_19525	COG0385	Bile acid
MID00_19530	COG0697	spore germination
MID00_19535	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
MID00_19540	COG0840	transmembrane signaling receptor activity
MID00_19550	COG4221	oxidoreductase activity
MID00_19555	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
MID00_19560	COG3181	Tripartite tricarboxylate transporter family receptor
MID00_19570	COG0316	Belongs to the HesB IscA family
MID00_19580	COG1104	cysteine desulfurase activity
MID00_19590	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
MID00_19595	COG0556	nucleotide-excision repair
MID00_19615	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
MID00_19625	COG0740	serine-type endopeptidase activity
MID00_19630	COG0544	peptidyl-prolyl cis-trans isomerase activity
MID00_19635	COG1804	L-carnitine dehydratase bile acid-inducible protein F
MID00_19670	COG3179	chitinase
MID00_19905	COG1278	Cold shock
MID00_19960	COG4725	Belongs to the MT-A70-like family
MID00_20030	COG0471	metal ion transport
MID00_20030	COG3273	potassium ion transport
MID00_20040	COG2207	Transcriptional regulator
MID00_20050	COG2171	N-acyltransferase activity
MID00_20055	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
MID00_20060	COG2890	protein-(glutamine-N5) methyltransferase activity
MID00_20065	COG0488	(ABC) transporter
MID00_20120	COG0210	DNA helicase
MID00_20130	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
MID00_20130	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
MID00_20135	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
MID00_20140	COG0196	riboflavin kinase activity
MID00_20145	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
MID00_20150	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
MID00_20160	COG0756	dUTP diphosphatase activity
MID00_20165	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
MID00_20200	COG0559	Belongs to the binding-protein-dependent transport system permease family
MID00_20220	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
MID00_20220	COG3008	intermembrane lipid transfer
MID00_20225	COG2995	paraquat-inducible protein a
MID00_20230	COG0542	response to heat
MID00_20235	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
MID00_20240	COG1278	Cold shock
MID00_20250	COG0183	Belongs to the thiolase family
MID00_20265	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
MID00_20270	COG1570	exodeoxyribonuclease VII activity
MID00_20275	COG0811	peptide transport
MID00_20280	COG0848	biopolymer transport protein
MID00_20285	COG1663	tetraacyldisaccharide 4'-kinase activity
MID00_20290	COG2835	tetraacyldisaccharide 4'-kinase activity
MID00_20295	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
MID00_20300	COG0563	adenylate kinase activity
MID00_20310	COG0728	peptidoglycan biosynthetic process
MID00_20315	COG0268	Binds directly to 16S ribosomal RNA
MID00_20320	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
MID00_20330	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
MID00_20335	COG0745	RESPONSE REGULATOR receiver
MID00_20340	COG2205	protein histidine kinase activity
MID00_20345	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
MID00_20355	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
MID00_20365	COG0519	Catalyzes the synthesis of GMP from XMP
MID00_20365	COG0518	GMP synthase (glutamine-hydrolyzing) activity
MID00_20370	COG1609	Transcriptional regulator
MID00_20390	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
MID00_20395	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
MID00_20400	COG0137	argininosuccinate synthase activity
MID00_20410	COG2832	Protein of unknown function (DUF454)
MID00_20415	COG0494	nUDIX hydrolase
MID00_20425	COG0626	cystathionine gamma-synthase activity
MID00_20430	COG1522	sequence-specific DNA binding
MID00_20445	COG2199	diguanylate cyclase activity
MID00_20495	COG3772	lysozyme
MID00_20505	COG0582	viral genome integration into host DNA