locus-tag	class	description
S7S_00005	ENOG4105CI4	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity)
S7S_00010	ENOG4105CZ8	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity)
S7S_00020	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
S7S_00030	ENOG4105VFQ	Histone family protein nucleoid-structuring protein H-NS
S7S_00040	ENOG4108ZI0	d,d-heptose 1,7-bisphosphate phosphatase
S7S_00045	ENOG4105C38	Glycyl-tRNA synthetase beta subunit
S7S_00050	ENOG4108HMW	glycyl-tRNA synthetase, alpha subunit
S7S_00055	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
S7S_00085	ENOG4105CBH	Hydroxymethylglutaryl-CoA lyase
S7S_00090	ENOG4107S2Z	UPF0761 membrane protein
S7S_00105	ENOG4105C1G	acyl-Coa dehydrogenase
S7S_00115	ENOG4105EMF	GntR family transcriptional regulator
S7S_00120	ENOG4105EEF	Alkane 1-monooxygenase
S7S_00125	ENOG4105D37	Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity)
S7S_00130	ENOG4105C1A	potassium transporter peripheral membrane
S7S_00135	ENOG4105CYJ	ribosomal RNA small subunit methyltransferase B
S7S_00140	ENOG4105CAE	Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity)
S7S_00145	ENOG4108Z02	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity)
S7S_00155	ENOG4105C79	DNA protecting protein DprA
S7S_00160	ENOG4105EK0	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
S7S_00165	ENOG4105DBS	Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity)
S7S_00170	ENOG4105E2X	shikimate dehydrogenase
S7S_00180	ENOG4108Z0R	Transferase
S7S_00185	ENOG4105DGW	oligopeptidase A
S7S_00195	ENOG4105YAJ	CopG Arc MetJ
S7S_00220	ENOG4105EEF	Alkane 1-monooxygenase
S7S_00245	ENOG4105CJX	Molecular chaperone. Has ATPase activity (By similarity)
S7S_00255	ENOG4105CB5	ATP-dependent DNA helicase recG
S7S_00260	ENOG4105C5Q	Transcriptional regulator
S7S_00270	ENOG4105KME	endoribonuclease L-psp
S7S_00275	ENOG4105CWR	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity)
S7S_00280	ENOG4105VFG	Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity)
S7S_00285	ENOG4108UHA	Essential for recycling GMP and indirectly, cGMP (By similarity)
S7S_00295	ENOG4107QXG	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
S7S_00335	ENOG4105W1Y	Transcriptional regulator
S7S_00345	ENOG4105IFJ	Histidine kinase
S7S_00370	ENOG4105DSJ	YicC domain protein
S7S_00375	ENOG4105ED0	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity)
S7S_00380	ENOG4107QP2	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity)
S7S_00390	ENOG4105EC0	Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity)
S7S_00395	ENOG4105CAS	nag kinase
S7S_00405	ENOG4108Z1K	This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity)
S7S_00415	ENOG4105W5Q	DNA repair protein (RadC
S7S_00420	ENOG4105KDC	50s ribosomal protein l28
S7S_00435	ENOG4105CGB	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity)
S7S_00440	ENOG4105E0C	molybdate abc transporter
S7S_00445	ENOG4108S6J	ABC transporter, periplasmic molybdate-binding protein
S7S_00515	ENOG4105ERD	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity)
S7S_00540	ENOG4108ZEF	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity)
S7S_00555	ENOG4107RGH	Aldehyde dehydrogenase
S7S_00565	ENOG4105CHU	acetyl-coa acetyltransferase
S7S_00575	ENOG4105D6N	CoA-transferase, subunit a
S7S_00580	ENOG4108M0I	Transcriptional regulator
S7S_00590	ENOG4105CHM	Aminotransferase
S7S_00620	ENOG4108M9J	MaoC like domain protein
S7S_00630	ENOG4105CG6	trap dicarboxylate transporter dctm subunit
S7S_00650	ENOG4106H78	methyltransferase
S7S_00665	ENOG4105CCP	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)
S7S_00670	ENOG4105CAK	Cell division ATP-binding protein ftsE
S7S_00675	ENOG4105CRP	Part of the ABC transporter FtsEX involved in
S7S_00680	ENOG4105DEK	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
S7S_00690	ENOG4105CA8	Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity)
S7S_00695	ENOG4105CA8	Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity)
S7S_00705	ENOG4105C77	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity)
S7S_00710	ENOG4108HWY	Beta-lactamase
S7S_00715	ENOG4105DH7	May be involved in recombination (By similarity)
S7S_00730	ENOG4105CZ1	Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity)
S7S_00740	ENOG4105SYT	Methylenetetrahydrofolate reductase
S7S_00745	ENOG4105C3E	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity)
S7S_00750	ENOG4105CPH	Catalyzes the formation of S-adenosylmethionine from methionine and ATP
S7S_00760	ENOG4108R86	Transcriptional regulator
S7S_00765	ENOG4105FQ6	thiopurine methyltransferase
S7S_00845	ENOG4105CV1	Transketolase (EC 2.2.1.1)
S7S_00850	ENOG4105C17	glyceraldehyde-3-phosphate dehydrogenase
S7S_00855	ENOG4105BZA	Phosphoglycerate kinase
S7S_00860	ENOG4105D2N	Aldolase
S7S_00905	ENOG4108JQ1	Dehydrogenase
S7S_00910	ENOG4105CQB	FAD linked oxidase domain protein
S7S_00915	ENOG4105FBJ	fumarylacetoacetate (faa) hydrolase
S7S_00925	ENOG4105E66	phosphoriboisomerase A
S7S_00930	ENOG4105C7B	Threonine dehydratase
S7S_00940	ENOG4105MK2	5-formyltetrahydrofolate cyclo-ligase
S7S_00945	ENOG4105W8B	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity)
S7S_00955	ENOG4105E07	UPF0149 protein
S7S_00960	ENOG4107RAQ	aminopeptidase
S7S_00965	ENOG4105D0A	hydroxylase
S7S_00970	ENOG4105EAK	ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family
S7S_00980	ENOG4105EJ3	Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2- amino-6-oxopimelate using succinyl-CoA (By similarity)
S7S_00990	ENOG4107QKW	extracellular solute-binding protein family 1
S7S_01020	ENOG4105D43	The glycine cleavage system catalyzes the degradation of glycine (By similarity)
S7S_01025	ENOG4105KE9	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity)
S7S_01030	ENOG4107QK8	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
S7S_01035	ENOG4105CBI	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
S7S_01050	ENOG4105KPV	Transcriptional regulator
S7S_01060	ENOG4105DSQ	Nitric oxide reductase
S7S_01085	ENOG4105E39	Enoyl-CoA hydratase
S7S_01095	ENOG4108RXW	HAD-superfamily subfamily IB hydrolase
S7S_01100	ENOG4105EJF	Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity)
S7S_01105	ENOG4108HRM	phosphoenolpyruvate--protein phosphotransferase
S7S_01120	ENOG4105HF0	Membrane
S7S_01125	ENOG4105C3B	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity)
S7S_01130	ENOG4105C0V	Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity)
S7S_01155	ENOG4106EDX	Hemin uptake protein
S7S_01165	ENOG4105DR9	pseudouridine synthase
S7S_01195	ENOG41077A9	carbonic anhydrase
S7S_01210	ENOG4108IYS	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
S7S_01220	ENOG4105E4Z	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity)
S7S_01230	ENOG4105F4G	Membrane
S7S_01235	ENOG4105D0U	Arsenite-activated ATPase (ArsA)
S7S_01245	ENOG4105D22	carbon starvation protein
S7S_01255	ENOG4105CU5	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity)
S7S_01265	ENOG4105NXH	GreA GreB family elongation factor
S7S_01270	ENOG41064MX	Tetr family transcriptional regulator
S7S_01280	ENOG4105CH7	arginosuccinase
S7S_01285	ENOG4108HRK	Histidine kinase
S7S_01290	ENOG4108NEV	two component transcriptional regulator, LytTR family
S7S_01330	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
S7S_01340	ENOG4105DJ1	Phosphoenolpyruvate Carboxylase
S7S_01345	ENOG4105F4C	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity)
S7S_01350	ENOG4105VEJ	Heat shock protein
S7S_01355	ENOG4107Y3D	HAD-superfamily hydrolase subfamily IA variant 3
S7S_01360	ENOG4107RK2	ADP-ribose diphosphatase NudE
S7S_01365	ENOG4108RNI	3'(2')5'-bisphosphate nucleotidase
S7S_01380	ENOG4105C1I	TRANSCRIPTIONAl REGULATOR GntR family
S7S_01395	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
S7S_01410	ENOG4105KMG	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes (By similarity)
S7S_01415	ENOG4105CEN	a g-specific adenine glycosylase
S7S_01435	ENOG4105ECC	imidazole-glycerol-phosphate dehydratase
S7S_01440	ENOG4108UJE	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity)
S7S_01445	ENOG4105CJV	Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase
S7S_01455	ENOG4105C0S	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity)
S7S_01460	ENOG4105C09	Bile acid
S7S_01465	ENOG4105PXI	polysaccharide deacetylase
S7S_01470	ENOG4105CN1	protease
S7S_01475	ENOG41063SB	peptidase
S7S_01480	ENOG4107YZP	Rhodanese domain protein
S7S_01485	ENOG4105VW4	glutaredoxin 3
S7S_01490	ENOG4105IX2	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity)
S7S_01495	ENOG4108UIQ	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity)
S7S_01505	ENOG4105D9I	Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity)
S7S_01515	ENOG4105D9I	Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity)
S7S_01520	ENOG4105E68	Sulfatase
S7S_01545	ENOG4105CCJ	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity)
S7S_01550	ENOG4105VFE	sira family
S7S_01555	ENOG4105C5F	glutamine synthetase
S7S_01565	ENOG4105CUX	Signal transduction histidine kinase
S7S_01570	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
S7S_01585	ENOG4108YYA	Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity)
S7S_01610	ENOG4105X8U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity)
S7S_01615	ENOG4105WKS	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity)
S7S_01620	ENOG4105KPZ	phosphoribosyl-atp pyrophosphatase
S7S_01625	ENOG4105CNK	Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity)
S7S_01635	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
S7S_01645	ENOG4105C4N	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity)
S7S_01650	ENOG4108R5P	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity)
S7S_01660	ENOG4105C75	arginyL-tRNA synthetase
S7S_01665	ENOG4105C25	Primosomal protein n'
S7S_01670	ENOG4105VFB	Binds the 23S rRNA (By similarity)
S7S_01675	ENOG4105C6K	Malic enzyme
S7S_01680	ENOG4108JQC	penicillin-binding protein 1A
S7S_01705	ENOG4105E4G	Type IV pilus
S7S_01710	ENOG4105KHV	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity)
S7S_01715	ENOG4105D49	3-dehydroquinate synthase
S7S_01725	ENOG4105CBC	glutamate synthase
S7S_01730	ENOG4105BZ8	glutamate synthase
S7S_01735	ENOG4105CFZ	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity)
S7S_01760	ENOG41090A4	Pterin carbinolamine dehydratase
S7S_01770	ENOG4105C1G	acyl-Coa dehydrogenase
S7S_01775	ENOG4108N5B	2-phosphosulfolactate phosphatase
S7S_01785	ENOG4105MJ2	Competence protein
S7S_01790	ENOG4105CZF	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity)
S7S_01795	ENOG4107EEK	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity)
S7S_01800	ENOG4105D3C	The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity)
S7S_01805	ENOG410626R	Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity)
S7S_01810	ENOG4105E78	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity)
S7S_01840	ENOG4105K85	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity)
S7S_01860	ENOG4108UKH	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity)
S7S_01880	ENOG4108Z6Z	Transcriptional regulator
S7S_01900	ENOG4105E3B	Multicopper oxidase
S7S_01915	ENOG4105D05	Receptor
S7S_01930	ENOG4105CYQ	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity)
S7S_01935	ENOG4108TEB	UPF0114 protein
S7S_01940	ENOG4105C3D	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
S7S_01955	ENOG4108821	RND type efflux pump
S7S_01970	ENOG4105EXG	Transcriptional regulator
S7S_01980	ENOG4107SJW	iron permease, FTR1
S7S_01985	ENOG4108YZY	peptidylprolyl cis-trans isomerase
S7S_01990	ENOG4105CM1	Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
S7S_02000	ENOG4105PGM	cation diffusion facilitator family transporter
S7S_02005	ENOG4105D3H	Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity)
S7S_02020	ENOG4105C4P	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity)
S7S_02025	ENOG4105K63	Thioredoxin
S7S_02030	ENOG4105C9X	ppx gppa phosphatase
S7S_02040	ENOG4105D52	delta-aminolevulinic acid dehydratase
S7S_02045	ENOG4107QN2	dihydrolipoyl dehydrogenase
S7S_02055	ENOG4108RRZ	Transcription elongation factor GreB
S7S_02065	ENOG4108556	Isoprenoid biosynthesis protein with amidotransferase-like domain
S7S_02070	ENOG4105C5H	ABC transporter
S7S_02085	ENOG4108V1T	peptidylprolyl cis-trans isomerase
S7S_02095	ENOG4105PBF	Anti-RNA polymerase sigma 70 factor
S7S_02100	ENOG41080I0	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity)
S7S_02110	ENOG4105D9M	gamma-glutamylcysteine synthetase
S7S_02115	ENOG4105BZM	domain protein
S7S_02120	ENOG4105M3Z	response regulator
S7S_02130	ENOG4105DPZ	Two component transcriptional regulator (Winged helix family
S7S_02145	ENOG4105WH1	Two component transcriptional regulator luxr family
S7S_02160	ENOG4105E0F	Histidine kinase
S7S_02170	ENOG4105CEP	NADH dehydrogenase
S7S_02175	ENOG4105D6W	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity)
S7S_02195	ENOG4105CFX	Catalyzes the ferrous insertion into protoporphyrin IX (By similarity)
S7S_02220	ENOG4107QZM	n-acetylglutamate synthase
S7S_02225	ENOG4105CJ3	phosphate transporter
S7S_02230	ENOG4107IX6	phosphate transport regulator
S7S_02235	ENOG4107QHF	type ii secretion system protein e
S7S_02240	ENOG4105CE6	Adenylation and deadenylation of glutamate--ammonia ligase (By similarity)
S7S_02245	ENOG4105CM2	brancheD-chain amino acid aminotransferase
S7S_02250	ENOG4105XA0	heptosyltransferase ii
S7S_02255	ENOG4105D16	lipopolysaccharide heptosyltransferase i
S7S_02260	ENOG4107RJ7	Glycosyl transferase (Group 1
S7S_02265	ENOG4107543	(lipo)polysaccharide
S7S_02290	ENOG4107R5M	Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity)
S7S_02295	ENOG4105D1S	lipid A biosynthesis
S7S_02310	ENOG4105D1S	lipid A biosynthesis
S7S_02315	ENOG4105DW0	Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity)
S7S_02320	ENOG4105CPC	Aldo Keto reductase
S7S_02325	ENOG41087SS	fad dependent oxidoreductase
S7S_02330	ENOG4105D8A	3-Deoxy-D-manno-octulosonic-acid transferase
S7S_02335	ENOG4105DFG	type I secretion outer membrane protein
S7S_02340	ENOG4105CBF	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity)
S7S_02345	ENOG41087AY	ADP-Ribose pyrophosphatase
S7S_02355	ENOG41070EG	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity)
S7S_02360	ENOG4105IPS	esterase
S7S_02365	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
S7S_02370	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
S7S_02375	ENOG4105ISI	outer membrane protein, OMPP1 FadL TodX family
S7S_02385	ENOG4105I08	Pseudouridine synthase
S7S_02410	ENOG4105W5Q	DNA repair protein (RadC
S7S_02415	ENOG4105E27	serine threonine protein kinase
S7S_02445	ENOG4105D6P	C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex (By similarity)
S7S_02460	ENOG4105EUH	cytochrome C oxidase, cbb3-type, subunit i
S7S_02485	ENOG4105BZ4	penicillin-binding protein
S7S_02495	ENOG4105VTW	prevent-host-death family
S7S_02500	ENOG4105KRQ	Addiction module toxin, Txe YoeB family
S7S_02595	ENOG4108M24	von Willebrand factor, type A
S7S_02605	ENOG4105M0J	Toxic component of a toxin-antitoxin (TA) module. A
S7S_02615	ENOG4105CDM	Glutamate-1-semialdehyde aminotransferase
S7S_02620	ENOG4108UV6	Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity)
S7S_02625	ENOG4105DWF	phosphomethylpyrimidine kinase
S7S_02630	ENOG4108YXA	Membrane
S7S_02635	ENOG4105C0N	N-acetylglutamate semialdehyde dehydrogenase
S7S_02650	ENOG4108YX9	iron--sulfur cluster insertion protein erpA
S7S_02660	ENOG4105VRT	cytoplasmic protein
S7S_02665	ENOG4105ED7	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity)
S7S_02670	ENOG4105DR5	peptidase
S7S_02675	ENOG4105DA0	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity)
S7S_02680	ENOG4105CMM	transposase
S7S_02705	ENOG4105CER	acetyl-CoA carboxylase biotin carboxylase
S7S_02720	ENOG4105C32	Amino acid ABC transporter (Permease)
S7S_02735	ENOG4105D5T	phosphonate abc transporter
S7S_02740	ENOG4108IV0	ABC, transporter
S7S_02755	ENOG4105HJX	Biotin- acetyl-CoA-carboxylase ligase
S7S_02760	ENOG4108194	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity)
S7S_02770	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
S7S_02775	ENOG4105PM1	preprotein translocase subunit SecE
S7S_02780	ENOG4105E5V	Participates in transcription elongation, termination and antitermination (By similarity)
S7S_02785	ENOG4108UIK	This protein binds directly to 23S ribosomal RNA (By similarity)
S7S_02790	ENOG4105C64	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity)
S7S_02800	ENOG4105KBC	Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity)
S7S_02805	ENOG4108IIJ	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
S7S_02810	ENOG4105D27	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
S7S_02815	ENOG4108UKE	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity)
S7S_02820	ENOG4108UHY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity)
S7S_02825	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
S7S_02830	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
S7S_02835	ENOG4108Z10	Involved in the binding of tRNA to the ribosomes (By similarity)
S7S_02840	ENOG4105EEE	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity)
S7S_02845	ENOG4106U5A	One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity)
S7S_02850	ENOG41080KG	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity)
S7S_02855	ENOG4105CFD	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
S7S_02860	ENOG4105K7S	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity)
S7S_02865	ENOG4105KAP	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity)
S7S_02870	ENOG4105CKE	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity)
S7S_02875	ENOG4108R70	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity)
S7S_02880	ENOG41083MP	50s ribosomal protein l29
S7S_02885	ENOG4105K87	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal
S7S_02890	ENOG4108UNN	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity)
S7S_02895	ENOG4105KAR	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity)
S7S_02900	ENOG4105CW6	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
S7S_02905	ENOG4105VBI	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity)
S7S_02910	ENOG4108UJY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity)
S7S_02915	ENOG4108R5J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity)
S7S_02920	ENOG4105K4C	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity)
S7S_02925	ENOG4108RA9	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity)
S7S_02930	ENOG4105VPB	50S ribosomal protein L30
S7S_02935	ENOG4108UZ0	Binds to the 23S rRNA (By similarity)
S7S_02940	ENOG4105CGG	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity)
S7S_02945	ENOG41067V7	50S ribosomal protein L36
S7S_02955	ENOG4108UHH	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity)
S7S_02960	ENOG4105G6W	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity)
S7S_02965	ENOG4105CTF	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
S7S_02970	ENOG4108ZT0	50S ribosomal protein l17
S7S_02980	ENOG4105C5U	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity)
S7S_02985	ENOG41086KC	Transcriptional regulator
S7S_02990	ENOG4107RDB	Major Facilitator
S7S_02995	ENOG4108UUM	single-stranded DNA-binding protein
S7S_03010	ENOG4105GVR	general secretion pathway protein D
S7S_03025	ENOG4105F8J	Adenylate Guanylate cyclase
S7S_03045	ENOG4105CUJ	penicillin amidase
S7S_03050	ENOG4105PDP	Short chain dehydrogenase
S7S_03065	ENOG4105PDP	Short chain dehydrogenase
S7S_03080	ENOG4108TKH	Nitroreductase
S7S_03095	ENOG4105C6P	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity)
S7S_03105	ENOG4105BZU	Histidine kinase
S7S_03135	ENOG4107EXU	Short-chain dehydrogenase reductase Sdr
S7S_03140	ENOG4108ZX5	transcriptional regulator
S7S_03165	ENOG4105EAH	synthase
S7S_03170	ENOG4105KK9	This protein binds to 23S rRNA in the presence of protein L20 (By similarity)
S7S_03175	ENOG4105K46	50S ribosomal protein l27
S7S_03180	ENOG4105C9R	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
S7S_03185	ENOG4105CGT	Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity)
S7S_03190	ENOG4105KQV	Binds directly to 16S ribosomal RNA (By similarity)
S7S_03195	ENOG4105CJR	Integral membrane protein (MviN
S7S_03200	ENOG4105DTN	riboflavin biosynthesis protein ribF
S7S_03205	ENOG4105C07	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity)
S7S_03210	ENOG4105M02	This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity)
S7S_03215	ENOG41090X3	Peptidyl-prolyl cis-trans isomerase
S7S_03220	ENOG4105C48	Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity)
S7S_03265	ENOG4105MWK	D-amino acid dehydrogenase, small subunit
S7S_03270	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
S7S_03275	ENOG4107TUY	Histidine kinase
S7S_03285	ENOG4105C4K	Nad synthetase
S7S_03290	ENOG4106SNF	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
S7S_03295	ENOG4105C34	Pseudouridine synthase
S7S_03300	ENOG4105DBW	Multi-copper polyphenol oxidoreductase laccase
S7S_03305	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
S7S_03315	ENOG4105C7K	acetolactate synthase
S7S_03320	ENOG4108ZP8	Acetolactate synthase small subunit
S7S_03360	ENOG4108MCI	Transcriptional regulator, ARAC family
S7S_03450	ENOG4105KCV	RNA signal recognition particle 4.5S RNA
S7S_03460	ENOG4105EMY	transcriptional regulator
S7S_03465	ENOG4105C6M	Alpha-keto-beta-hydroxylacyl reductoisomerase
S7S_03470	ENOG4106PT6	cdpdiacylglycerol-serine O-phosphatidyltransferase
S7S_03500	ENOG4105BZS	acriflavin resistance protein
S7S_03505	ENOG4105C8Q	Methyl-accepting chemotaxis
S7S_03530	ENOG4105R8C	Transcriptional regulator
S7S_03535	ENOG4105CA4	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity)
S7S_03545	ENOG4105MYG	DNA polymerase iii, chi subunit
S7S_03550	ENOG4105BZ6	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity)
S7S_03555	ENOG4108M8S	permease YjgP YjgQ family protein
S7S_03560	ENOG4108K5H	permease YjgP YjgQ family protein
S7S_03570	ENOG4105E2N	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity)
S7S_03575	ENOG4105C6U	Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity)
S7S_03580	ENOG4105VIE	preprotein translocase, subunit YajC
S7S_03585	ENOG4107QN8	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
S7S_03590	ENOG4107RAB	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
S7S_03595	ENOG4105CHM	Aminotransferase
S7S_03600	ENOG4105C3P	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity)
S7S_03610	ENOG4108JPW	Aminotransferase
S7S_03615	ENOG4105C0C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity)
S7S_03620	ENOG4105C26	Dehydrogenase
S7S_03630	ENOG4105ECY	inositol monophosphatase
S7S_03645	ENOG4108ZF1	Transcriptional regulator, BadM Rrf2 family
S7S_03650	ENOG4105C3J	Cysteine desulfurase
S7S_03665	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
S7S_03670	ENOG4105F38	ABC transporter, permease
S7S_03675	ENOG4105D38	putrescine abc transporter
S7S_03680	ENOG4107RUE	extracellular solute-binding protein family 1
S7S_03705	ENOG4105P9C	Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity)
S7S_03715	ENOG4108Z4V	iron-sulfur cluster assembly
S7S_03740	ENOG4108UGX	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity)
S7S_03745	ENOG4105C55	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs
S7S_03760	ENOG4105C4E	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity)
S7S_03765	ENOG4105CUT	histidyl-tRNA synthetase
S7S_03770	ENOG4105N21	Membrane
S7S_03775	ENOG4105CNE	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity)
S7S_03780	ENOG4105DKZ	GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity)
S7S_03785	ENOG4107RNH	Outer membrane receptor FepA
S7S_03795	ENOG4105BZU	Histidine kinase
S7S_03800	ENOG4105DVS	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity)
S7S_03805	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
S7S_03810	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
S7S_03820	ENOG4107QJF	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity)
S7S_03835	ENOG4105CYM	Glutathione S-transferase
S7S_03865	ENOG4105CSW	GntR family transcriptional regulator
S7S_03870	ENOG4105BZ8	glutamate synthase
S7S_03875	ENOG4108RMV	DegV Family
S7S_03885	ENOG4105ETT	transcriptional Regulator, LysR family
S7S_03890	ENOG4107U5X	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity)
S7S_03895	ENOG4105CBD	Diacylglycerol kinase
S7S_03905	ENOG4105ECQ	AraC Family Transcriptional Regulator
S7S_03920	ENOG4108MUX	N-hydroxyarylamine O-acetyltransferase
S7S_03930	ENOG4105DJ2	Major Facilitator Superfamily
S7S_03945	ENOG4107EXC	regulatoR
S7S_03950	ENOG4105JJR	Histidine kinase
S7S_03970	ENOG4108V1U	phospholipid-binding protein
S7S_04005	ENOG410689M	(LipO)protein
S7S_04010	ENOG4105WXT	Conserved Protein
S7S_04015	ENOG4105EE5	Membrane protein terC
S7S_04030	ENOG4108FN7	Aldo keto reductase
S7S_04035	ENOG4105CBN	LysR family transcriptional regulator
S7S_04045	ENOG4105EXU	Membrane
S7S_04060	ENOG4105C1P	efflux transporter, rnd family, mfp subunit
S7S_04085	ENOG4108HH9	Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR
S7S_04090	ENOG4108Z6B	deaminase
S7S_04095	ENOG4105CHQ	Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity)
S7S_04100	ENOG4108ETH	Formylglycinamide ribotide synthetase
S7S_04125	ENOG4105EGD	dinuclear metal center protein, YbgI family
S7S_04140	ENOG4105MYN	Zinc uptake regulation protein
S7S_04145	ENOG4105CKI	cobalamin synthesis protein
S7S_04150	ENOG4105E09	nadh pyrophosphatase
S7S_04160	ENOG4108Z0R	Transferase
S7S_04170	ENOG4105D78	K07001 NTE family protein
S7S_04180	ENOG4108JU6	CBS domain protein
S7S_04190	ENOG4105CB9	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
S7S_04195	ENOG4105K5M	30s ribosomal protein S16
S7S_04200	ENOG4108ZR6	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity)
S7S_04205	ENOG4105D6X	Specifically methylates guanosine-37 in various tRNAs (By similarity)
S7S_04210	ENOG4108YY1	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity)
S7S_04215	ENOG4105Y3U	Transglycosylase-associated protein
S7S_04220	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
S7S_04225	ENOG4105T95	Thiol disulfide interChange protein
S7S_04230	ENOG4105CHM	Aminotransferase
S7S_04235	ENOG4105D6E	homoserine dehydrogenase
S7S_04265	ENOG4108ZX5	transcriptional regulator
S7S_04275	ENOG4107S1E	Beta-lactamase
S7S_04285	ENOG4108Z66	YbaK ebsC protein
S7S_04295	ENOG4105C04	l-carnitine dehydratase bile acid-inducible protein F
S7S_04305	ENOG4105F59	Methylates ribosomal protein L11 (By similarity)
S7S_04310	ENOG4105C0H	protease
S7S_04340	ENOG4105CWB	LysR family transcriptional Regulator
S7S_04345	ENOG4105C2I	pirin domain protein
S7S_04350	ENOG4108VBZ	doxx family
S7S_04365	ENOG4105E5N	succinylglutamate desuccinylase aspartoacylase
S7S_04370	ENOG4105C5H	ABC transporter
S7S_04380	ENOG4108JQB	penicillin-binding protein 1C
S7S_04385	ENOG4105BZ1	(ABC) transporter
S7S_04405	ENOG4105DA5	(ABC) transporter
S7S_04410	ENOG4105E3A	(ABC) transporter
S7S_04415	ENOG4105EGS	Mechanosensitive ion channel
S7S_04430	ENOG4105EV8	ectoine hydroxylase
S7S_04445	ENOG4105JAB	phenazine biosynthesis protein, phzf family
S7S_04455	ENOG4106YT9	Enoyl-CoA hydratase
S7S_04460	ENOG4105CHT	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
S7S_04465	ENOG4105C3P	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity)
S7S_04470	ENOG41080G2	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
S7S_04475	ENOG4105DFF	Rod shape-determining protein mreb
S7S_04480	ENOG4105N3I	Involved in formation and maintenance of cell shape (By similarity)
S7S_04485	ENOG4105VQ7	Rod shape-determining protein MreD
S7S_04490	ENOG4108Z03	MAF-like protein
S7S_04505	ENOG4105D1U	peptidase U62 modulator of DNA gyrase
S7S_04510	ENOG4105EYW	Ion transport protein
S7S_04520	ENOG4105CMS	peptidase U62, modulator of DNA gyrase
S7S_04530	ENOG41080Z8	PHOSPHOCARRIER protein
S7S_04535	ENOG4105C21	Displays ATPase and GTPase activities (By similarity)
S7S_04540	ENOG4107RM2	PTS IIA-like nitrogen-regulatory protein PtsN
S7S_04545	ENOG41080QH	sigma 54 modulation protein ribosomal protein S30EA
S7S_04550	ENOG4105DTW	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
S7S_04555	ENOG4108IUZ	ABC transporter
S7S_04575	ENOG4105C2X	Arabinose 5-phosphate isomerase
S7S_04590	ENOG4105VFK	BolA family
S7S_04595	ENOG4105CDF	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity)
S7S_04600	ENOG4105E21	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity)
S7S_04605	ENOG4105CEK	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity)
S7S_04610	ENOG4105CIH	Imidazole acetol-phosphate transaminase
S7S_04615	ENOG4105C0H	protease
S7S_04620	ENOG4107QNR	UPF0135 protein
S7S_04625	ENOG4105CBD	Diacylglycerol kinase
S7S_04635	ENOG4105DHZ	alpha beta
S7S_04640	ENOG4105D6Z	AFG1 family ATPase
S7S_04645	ENOG4105C1G	acyl-Coa dehydrogenase
S7S_04685	ENOG4105EWK	phytoene
S7S_04695	ENOG4105CPC	Aldo Keto reductase
S7S_04705	ENOG4108UM5	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity)
S7S_04710	ENOG4108UJD	30S ribosomal protein S9
S7S_04715	ENOG4108R5F	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity)
S7S_04720	ENOG4105DJ5	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity)
S7S_04725	ENOG4105EIX	cytochrome c1
S7S_04730	ENOG4107MKT	Stringent starvation protein a
S7S_04735	ENOG4105KB2	stringent starvation protein b
S7S_04745	ENOG4105W4M	Transport-associated protein
S7S_04755	ENOG41082RQ	UPF0102 protein
S7S_04765	ENOG4105CU0	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity)
S7S_04770	ENOG4108V6E	Cell division protein mraZ
S7S_04775	ENOG4105CGJ	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity)
S7S_04785	ENOG4105CJN	penicillin-binding protein
S7S_04790	ENOG4107EEN	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity)
S7S_04795	ENOG4108EQQ	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity)
S7S_04800	ENOG4105CPY	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity)
S7S_04805	ENOG4105DMZ	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity)
S7S_04810	ENOG4105CNI	cell division protein FtsW
S7S_04815	ENOG4105DVQ	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity)
S7S_04820	ENOG4105DFU	Cell wall formation (By similarity)
S7S_04825	ENOG4105CPF	Cell wall formation (By similarity)
S7S_04830	ENOG4105K7E	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity)
S7S_04835	ENOG4105CIT	This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity)
S7S_04840	ENOG4105CDK	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity)
S7S_04855	ENOG4105DR5	peptidase
S7S_04860	ENOG4105CI6	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving
S7S_04865	ENOG4105C5V	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity)
S7S_04870	ENOG4108UV6	Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity)
S7S_04875	ENOG41067SF	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase (By similarity)
S7S_04880	ENOG4108ZQD	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity)
S7S_04895	ENOG4107QHF	type ii secretion system protein e
S7S_04910	ENOG4105EXC	Acyl-transferase
S7S_04955	ENOG4105D18	nicotinate-nucleotide pyrophosphorylase
S7S_04960	ENOG4105BZG	amino acid carrier protein
S7S_04970	ENOG4108VBV	N-Acetylmuramoyl-L-alanine amidase
S7S_04980	ENOG4105DAQ	Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity)
S7S_04985	ENOG4107QSN	dihydrolipoamide acetyltransferase
S7S_04995	ENOG4105E3W	Two component transcriptional regulator (Winged helix family
S7S_05000	ENOG4105EB3	Histidine kinase
S7S_05010	ENOG4108WBT	adenosyltransferase
S7S_05015	ENOG4105CHI	Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity)
S7S_05020	ENOG4108JZF	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity)
S7S_05030	ENOG4105EYM	Major Facilitator superfamily
S7S_05035	ENOG41080UX	Methyltransferase
S7S_05040	ENOG4105CHR	reductase
S7S_05045	ENOG4105K5Y	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity)
S7S_05050	ENOG4105CJ9	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
S7S_05060	ENOG4105CBG	Sulfatase
S7S_05070	ENOG4107QRH	Arylsulfatase (Ec 3.1.6.1)
S7S_05080	ENOG4105BZU	Histidine kinase
S7S_05085	ENOG4105WH1	Two component transcriptional regulator luxr family
S7S_05115	ENOG4105KEG	ribosomal-protein-alanine acetyltransferase
S7S_05120	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
S7S_05125	ENOG4105BZU	Histidine kinase
S7S_05160	ENOG4105BZU	Histidine kinase
S7S_05170	ENOG4105C8A	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity)
S7S_05175	ENOG4108Z8G	Alkylphosphonate utilization operon protein PhnA
S7S_05230	ENOG4107R73	Mate efflux family protein
S7S_05235	ENOG4108ZX5	transcriptional regulator
S7S_05240	ENOG4105EMU	Dehydrogenase
S7S_05245	ENOG4105F95	Monooxygenase
S7S_05255	ENOG4105DHU	Bile acid
S7S_05265	ENOG4107XDR	Lactoylglutathione lyase
S7S_05335	ENOG4105CEY	Amp-dependent synthetase and ligase
S7S_05355	ENOG4105E2Q	3-(3-hydroxy-phenyl)propionate hydroxylase
S7S_05360	ENOG410630P	Transcriptional regulator
S7S_05395	ENOG4105CNM	Receptor
S7S_05400	ENOG4105F1Y	L-lysine 6-monooxygenase (NADPH)
S7S_05415	ENOG4105IBP	Cyclic peptide transporter
S7S_05425	ENOG4105DHQ	Histidine kinase
S7S_05430	ENOG4105XJC	Two component transcriptional regulator (Winged helix family
S7S_05435	ENOG4105CSG	Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity)
S7S_05440	ENOG4107QXG	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
S7S_05445	ENOG4108KHN	disulfide isomerase, thiol-disulfide oxidase
S7S_05450	ENOG4105CQX	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity)
S7S_05460	ENOG4107U2T	alpha beta
S7S_05465	ENOG4107RX2	synthase
S7S_05470	ENOG4105CHU	acetyl-coa acetyltransferase
S7S_05475	ENOG4105CK4	Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity)
S7S_05530	ENOG4105CVR	type I restriction-modification system
S7S_05540	ENOG4105CVR	type I restriction-modification system
S7S_05555	ENOG4105DZR	Type I site-specific deoxyribonuclease
S7S_05585	ENOG4105C0D	helicase
S7S_05615	ENOG4105W5Q	DNA repair protein (RadC
S7S_05625	ENOG4105VUH	addiction module killer protein
S7S_05630	ENOG4105YES	addiction module antidote protein
S7S_05670	ENOG4105CDY	transcriptional regulatory protein
S7S_05680	ENOG4107QPN	acyl-Coa dehydrogenase
S7S_05720	ENOG4105CQ3	Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity)
S7S_05730	ENOG4105QPS	Monooxygenase
S7S_05745	ENOG4105CCA	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity)
S7S_05765	ENOG4105FUQ	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity)
S7S_05790	ENOG4108K1J	Transporter DctQ
S7S_05795	ENOG4105CG6	trap dicarboxylate transporter dctm subunit
S7S_05815	ENOG4107QM5	aconitate hydratase
S7S_05820	ENOG4105CKD	glutathione-regulated potassium-efflux system protein
S7S_05830	ENOG4105KPY	Small multidrug resistance protein
S7S_05840	ENOG4105C7K	acetolactate synthase
S7S_05850	ENOG41090TI	Catalyzes the excretion of spermidine (By similarity)
S7S_05860	ENOG4105E05	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
S7S_05865	ENOG4105BZH	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
S7S_05870	ENOG4107EXC	regulatoR
S7S_05875	ENOG4105JJR	Histidine kinase
S7S_05880	ENOG4108JQ0	Key enzyme in the regulation of glycerol uptake and metabolism (By similarity)
S7S_05885	ENOG4105BZU	Histidine kinase
S7S_05890	ENOG4105BZU	Histidine kinase
S7S_05905	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
S7S_05910	ENOG4105DBV	ornithine carbamoyltransferase
S7S_05915	ENOG4105C8Y	Acetylornithine aminotransferase
S7S_05930	ENOG4105M2J	Glutaredoxin
S7S_05955	ENOG4105CSU	acyl-Coa dehydrogenase
S7S_06000	ENOG4105KJM	monovalent cation h antiporter subunit g
S7S_06005	ENOG41080TA	Multiple resistance and ph regulation protein f
S7S_06010	ENOG4105SC1	monovalent cation H antiporter subunit E
S7S_06015	ENOG4108JPZ	Monovalent cation H antiporter subunit D
S7S_06020	ENOG4105MKQ	Monovalent cation H antiporter subunit C
S7S_06025	ENOG4105HC0	Na H antiporter
S7S_06030	ENOG4105D65	subunit l
S7S_06040	ENOG4105C7R	Atpase associated with various cellular activities aaa_3
S7S_06070	ENOG4105CS1	NAD(P)H quinone oxidoreductase
S7S_06075	ENOG4105K89	arsenate reductase
S7S_06080	ENOG4107S2Z	UPF0761 membrane protein
S7S_06085	ENOG4105VSY	K01512 acylphosphatase EC 3.6.1.7
S7S_06135	ENOG4105C9U	ATP-dependent DNA helicase RecQ
S7S_06150	ENOG4105F95	Monooxygenase
S7S_06165	ENOG4105EMN	RNA polymerase sigma factor
S7S_06180	ENOG4105EN6	Membrane
S7S_06210	ENOG41067SE	Tetr family transcriptional regulator
S7S_06215	ENOG4105CSU	acyl-Coa dehydrogenase
S7S_06220	ENOG4107SKI	cobyrinic Acid a,c-diamide synthase
S7S_06230	ENOG4105C90	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity)
S7S_06245	ENOG4105CFU	surface antigen
S7S_06250	ENOG4108UYB	regulatoR
S7S_06260	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
S7S_06290	ENOG4105C9M	aspartyl-trna synthetase
S7S_06295	ENOG4105CDY	transcriptional regulatory protein
S7S_06300	ENOG4105NHU	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity)
S7S_06305	ENOG4105KA4	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity)
S7S_06310	ENOG4105CKJ	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity)
S7S_06315	ENOG4107YD3	Thioesterase
S7S_06320	ENOG4105E02	MotA TolQ exbB proton channel
S7S_06325	ENOG4105M8F	Biopolymer transport protein exbD tolR
S7S_06335	ENOG4107R6Y	Involved in the TonB-independent uptake of proteins (By similarity)
S7S_06340	ENOG4105KCK	Peptidoglycan-associated lipoprotein
S7S_06345	ENOG4105UFD	tol-pal system protein YbgF
S7S_06350	ENOG4107VRB	Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity)
S7S_06355	ENOG4105FD2	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity)
S7S_06365	ENOG4108XDN	Transcriptional regulator
S7S_06370	ENOG4105CVP	deoxyribo-dipyrimidine photolyase
S7S_06390	ENOG4105D0I	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity)
S7S_06395	ENOG4105C1J	atp-dependent rna helicase
S7S_06400	ENOG4105ERG	peptidase m48, ste24p
S7S_06405	ENOG41082K8	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity)
S7S_06415	ENOG4108YXY	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
S7S_06420	ENOG4105RH4	Glycine cleavage system transcriptional repressor
S7S_06425	ENOG4105CDP	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity)
S7S_06435	ENOG4105Q2H	domain protein
S7S_06440	ENOG4105C8V	SAICAR synthetase
S7S_06450	ENOG4108JQ1	Dehydrogenase
S7S_06465	ENOG4105VUF	Transcriptional regulator
S7S_06485	ENOG4105EXN	Sulfate transport protein CysZ
S7S_06495	ENOG4107NPY	receptor for the septal ring structure, may anchor it to the inner-membrane (By similarity)
S7S_06500	ENOG4105C77	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity)
S7S_06525	ENOG4105DSS	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity)
S7S_06530	ENOG4105DZ2	Transcriptional regulator
S7S_06540	ENOG4105BZU	Histidine kinase
S7S_06575	ENOG4105CEY	Amp-dependent synthetase and ligase
S7S_06580	ENOG4105CI0	Citrate lyase
S7S_06600	ENOG4108M9J	MaoC like domain protein
S7S_06605	ENOG4105C04	l-carnitine dehydratase bile acid-inducible protein F
S7S_06620	ENOG4108ZX5	transcriptional regulator
S7S_06630	ENOG410900P	UPF0336 protein
S7S_06640	ENOG4105CHR	reductase
S7S_06650	ENOG4105CEY	Amp-dependent synthetase and ligase
S7S_06665	ENOG4108UKI	Enoyl-CoA hydratase
S7S_06670	ENOG4105KF3	Short-chain dehydrogenase reductase Sdr
S7S_06680	ENOG4105CHU	acetyl-coa acetyltransferase
S7S_06685	ENOG4105C1G	acyl-Coa dehydrogenase
S7S_06700	ENOG4105CEY	Amp-dependent synthetase and ligase
S7S_06720	ENOG4105EEF	Alkane 1-monooxygenase
S7S_06730	ENOG4105F95	Monooxygenase
S7S_06735	ENOG4105YP7	UPF0270 protein
S7S_06745	ENOG4105CWG	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity)
S7S_06770	ENOG4105CHR	reductase
S7S_06805	ENOG4105C0B	DNA polymerase III (alpha subunit)
S7S_06870	ENOG4108UWZ	4-Carboxymuconolactone decarboxylase
S7S_06880	ENOG41080ZE	Adenylate cyclase
S7S_06885	ENOG41063V1	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity)
S7S_06895	ENOG4105DCM	major facilitator superfamily
S7S_06910	ENOG4107EV4	once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity)
S7S_06915	ENOG4105CA5	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity)
S7S_06920	ENOG41060IM	Heme exporter protein
S7S_06925	ENOG41067VX	Heme exporter protein
S7S_06930	ENOG4108ZKK	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH (By similarity)
S7S_06935	ENOG4105W53	bacterioferritin-associated ferredoxin
S7S_06940	ENOG4108UQY	Iron-storage protein
S7S_06945	ENOG4108PVQ	transcriptional regulator
S7S_06955	ENOG4105CG6	trap dicarboxylate transporter dctm subunit
S7S_06970	ENOG4105CPQ	Dehydrogenase
S7S_06975	ENOG4107TVJ	,Oxidoreductase FAD NAD(P)-binding
S7S_06995	ENOG4105DIV	Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD( ) and coenzyme A. Is the final enzyme in the meta- cleavage pathway for the degradation of aromatic compounds (By similarity)
S7S_07000	ENOG4105DF3	Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta-cleavage pathway for the degradation of aromatic compounds (By similarity)
S7S_07025	ENOG4105RWS	endonuclease I
S7S_07050	ENOG41065DM	this blockage is overcome by subsequent expression of antitoxin YafN. Overexpression causes cleavage of a number of mRNAs in a ribosome-dependent fashion. YafO binding to the 50S ribosomal subunit in the translation complex induces mRNA cleavage 3' to the region protected by the ribosome
S7S_07065	ENOG4106AFN	Lyase and sodium transporter (By similarity)
S7S_07070	ENOG4107QSA	Oxaloacetate decarboxylase
S7S_07075	ENOG4105D9Q	decarboxylase (Beta subunit)
S7S_07080	ENOG4105DP0	ferredoxin-NADP reductase
S7S_07085	ENOG4105DUM	transcriptional regulator, lysR family
S7S_07090	ENOG4105C09	Bile acid
S7S_07100	ENOG4105DA5	(ABC) transporter
S7S_07105	ENOG4105E3A	(ABC) transporter
S7S_07110	ENOG4107R1K	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity)
S7S_07120	ENOG4105CFC	Transporter
S7S_07125	ENOG4105F8J	Adenylate Guanylate cyclase
S7S_07130	ENOG41069NU	Nitroreductase
S7S_07175	ENOG4105C1G	acyl-Coa dehydrogenase
S7S_07185	ENOG4105CHR	reductase
S7S_07190	ENOG41061TZ	Short-chain dehydrogenase reductase Sdr
S7S_07205	ENOG4105BZU	Histidine kinase
S7S_07215	ENOG4105DZG	Dehydrogenase
S7S_07235	ENOG4105C26	Dehydrogenase
S7S_07240	ENOG4105CNG	UPF0061 protein
S7S_07250	ENOG4105D3R	alkyl hydroperoxide reductase
S7S_07255	ENOG4105CHB	tonB-dependent Receptor
S7S_07260	ENOG4105BZS	acriflavin resistance protein
S7S_07265	ENOG4105C1P	efflux transporter, rnd family, mfp subunit
S7S_07270	ENOG4108IG5	Transcriptional regulator
S7S_07280	ENOG4105EE6	Alcohol dehydrogenase zinc-binding domain protein
S7S_07295	ENOG4105C0A	alcohol dehydrogenase
S7S_07315	ENOG4105ENE	Histidine kinase
S7S_07325	ENOG4107QPN	acyl-Coa dehydrogenase
S7S_07330	ENOG4105K63	Thioredoxin
S7S_07350	ENOG4105WD1	Membrane
S7S_07360	ENOG4105CYC	Transferase
S7S_07365	ENOG4105CNG	UPF0061 protein
S7S_07420	ENOG4105BZU	Histidine kinase
S7S_07425	ENOG4107QMP	dna polymerase iii subunits gamma and tau
S7S_07430	ENOG4105KDX	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity)
S7S_07435	ENOG4105F3K	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity)
S7S_07440	ENOG4105C1G	acyl-Coa dehydrogenase
S7S_07450	ENOG4108BPE	-transporting atpase
S7S_07500	ENOG4105CJ0	Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate (By similarity)
S7S_07515	ENOG4105D0M	Protease HtpX homolog
S7S_07530	ENOG4105CHM	Aminotransferase
S7S_07535	ENOG4105E0X	reductase
S7S_07540	ENOG4108R3E	Dna-3-methyladenine glycosylase i
S7S_07555	ENOG4107SQI	penicillin amidase
S7S_07575	ENOG4108821	RND type efflux pump
S7S_07580	ENOG4105K63	Thioredoxin
S7S_07605	ENOG4108JJ8	(ABC) transporter
S7S_07610	ENOG4108JJ9	ABC, transporter
S7S_07615	ENOG4105C4M	(Ubiquinol oxidase) subunit I
S7S_07620	ENOG4105CFY	cytochrome d ubiquinol oxidase, subunit ii
S7S_07635	ENOG4105D9I	Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity)
S7S_07650	ENOG4105CV6	ABC transporter, permease
S7S_07655	ENOG4108I0Y	(ABC) transporter
S7S_07660	ENOG4108UJV	acyl-CoA thioesterase i
S7S_07675	ENOG4105C99	atpase involved in dna repair
S7S_07680	ENOG4106HNH	Acyl-transferase
S7S_07685	ENOG4105C04	l-carnitine dehydratase bile acid-inducible protein F
S7S_07700	ENOG4105K9H	YciI-like protein
S7S_07705	ENOG4107835	probably involved in intracellular septation (By similarity)
S7S_07710	ENOG4105DB7	PHP domain protein
S7S_07715	ENOG4107RTD	sua5 ycio yrdc ywlc family protein
S7S_07720	ENOG4105C31	Tryptophanyl-tRNA synthetase
S7S_07730	ENOG4105K8I	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity)
S7S_07735	ENOG4105FE9	pseudouridine synthase
S7S_07825	ENOG4105DZP	Membrane-associated zinc metalloprotease
S7S_07830	ENOG4105CQ7	ATP-dependent helicase
S7S_07870	ENOG4105E18	UPF0276 protein
S7S_07880	ENOG410903C	(LipO)protein
S7S_07895	ENOG4105CW3	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity)
S7S_07900	ENOG4105CEH	Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity)
S7S_07905	ENOG4105DHQ	Histidine kinase
S7S_07910	ENOG4105XJC	Two component transcriptional regulator (Winged helix family
S7S_07930	ENOG4108IQE	Amp-dependent synthetase and ligase
S7S_07945	ENOG4105C20	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity)
S7S_07950	ENOG4105ECQ	AraC Family Transcriptional Regulator
S7S_07960	ENOG4105DSU	hydrolase
S7S_07965	ENOG4105CF3	3-Hydroxyisobutyrate dehydrogenase
S7S_07975	ENOG4105BZN	citrate synthase
S7S_07980	ENOG4108UTY	succinate dehydrogenase, cytochrome b556 subunit
S7S_07985	ENOG4105N1I	succinate dehydrogenase, hydrophobic membrane anchor protein
S7S_07990	ENOG4105C00	Succinate dehydrogenase (Flavoprotein subunit)
S7S_07995	ENOG4105E33	succinate dehydrogenase
S7S_08000	ENOG4105C7P	2-oxoglutarate dehydrogenase, E1
S7S_08005	ENOG4105C7S	Dehydrogenase
S7S_08015	ENOG4105CMV	Succinyl-CoA synthetase subunit beta
S7S_08020	ENOG4105CH8	Succinyl-CoA ligase ADP-forming subunit alpha
S7S_08040	ENOG4105ECP	epimerase
S7S_08045	ENOG4105CSF	NADPH-dependent glycerol-3-phosphate dehydrogenase
S7S_08055	ENOG4105KA0	thioesterase Superfamily protein
S7S_08060	ENOG4105CPI	Metal Dependent Phosphohydrolase
S7S_08070	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
S7S_08080	ENOG4105CGK	Exodeoxyribonuclease III
S7S_08120	ENOG41065U4	response regulator
S7S_08135	ENOG4105CK2	sodium dicarboxylate symporter
S7S_08160	ENOG4105C76	Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity)
S7S_08165	ENOG4105D10	5-enolpyruvylshikimate-3-phosphate phospholyase
S7S_08180	ENOG4105CQX	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity)
S7S_08185	ENOG4105CQX	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity)
S7S_08190	ENOG4105C4W	S-formylglutathione hydrolase
S7S_08195	ENOG4108MP6	LysR family Transcriptional regulator
S7S_08200	ENOG4105CQI	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
S7S_08205	ENOG4105MQS	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
S7S_08210	ENOG4105C0C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity)
S7S_08215	ENOG4105CM3	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity)
S7S_08230	ENOG4105DI7	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity)
S7S_08235	ENOG4108ZGB	N-(5'-phosphoribosyl)anthranilate isomerase
S7S_08240	ENOG4105CG0	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity)
S7S_08245	ENOG4105F6H	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity)
S7S_08250	ENOG4107QTG	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity)
S7S_08255	ENOG4105DPM	folylpolyglutamate synthase Dihydrofolate synthase
S7S_08265	ENOG4105E96	Colicin v production protein
S7S_08270	ENOG4105CBA	glutamine phosphoribosylpyrophosphate amidotransferase
S7S_08275	ENOG4105C28	cystathionine
S7S_08280	ENOG4105C7R	Atpase associated with various cellular activities aaa_3
S7S_08290	ENOG4105F8C	transglutaminase domain-containing protein
S7S_08295	ENOG4105NBK	UPF0345 protein
S7S_08300	ENOG4105CQ7	ATP-dependent helicase
S7S_08305	ENOG4108ZX5	transcriptional regulator
S7S_08360	ENOG4105CCT	upf0313 protein
S7S_08375	ENOG4108ZX5	transcriptional regulator
S7S_08380	ENOG4105C03	ribonuclease
S7S_08385	ENOG4105EI2	Pseudouridine synthase
S7S_08395	ENOG4108E8C	) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity)
S7S_08400	ENOG4108VBV	N-Acetylmuramoyl-L-alanine amidase
S7S_08405	ENOG4108UHJ	MAF-like protein
S7S_08410	ENOG4105FCQ	metal-binding, possibly nucleic acid-binding protein
S7S_08415	ENOG4105VGS	50s ribosomal protein l32
S7S_08420	ENOG4105C6B	Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity)
S7S_08425	ENOG4105CJF	Malonyl coA-acyl carrier protein transacylase
S7S_08430	ENOG4105CHR	reductase
S7S_08435	ENOG4105VNB	Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity)
S7S_08440	ENOG4105C0Q	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity)
S7S_08445	ENOG4105YAZ	4-amino-4-deoxychorismate lyase
S7S_08450	ENOG4105HHA	aminodeoxychorismate lyase
S7S_08455	ENOG4108ZMD	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity)
S7S_08460	ENOG4107QRG	dna polymerase iii
S7S_08470	ENOG4105F8V	Hydrolase, tatD family
S7S_08475	ENOG4105CGY	Dna recombination protein
S7S_08490	ENOG4105C3J	Cysteine desulfurase
S7S_08515	ENOG4105E99	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity)
S7S_08520	ENOG4105NDF	NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity)
S7S_08530	ENOG4105DGM	nitrilase cyanide hydratase and apolipoprotein n-acyltransferase
S7S_08535	ENOG41080ET	plasmid maintenance system killer protein
S7S_08540	ENOG4105VDM	plasmid maintenance system antidote protein, xre family
S7S_08545	ENOG4105DWH	electron transfer flavoprotein-ubiquinone oxidoreductase
S7S_08550	ENOG4105BZJ	Electron transfer flavoprotein
S7S_08555	ENOG4105C10	Electron transfer flavoprotein
S7S_08565	ENOG4105K7W	phage-related replication protein
S7S_08595	ENOG4107QX8	SPFH domain, Band 7 family protein
S7S_08625	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
S7S_08635	ENOG4108UKI	Enoyl-CoA hydratase
S7S_08640	ENOG4107QX3	carboxylase
S7S_08645	ENOG4105C1G	acyl-Coa dehydrogenase
S7S_08655	ENOG4105BZU	Histidine kinase
S7S_08665	ENOG4108YYX	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity)
S7S_08685	ENOG4105EP1	Efflux transporter rnd family, mfp subunit
S7S_08690	ENOG4108IJF	Heavy metal efflux pump, CzcA
S7S_08695	ENOG4105C80	Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity)
S7S_08705	ENOG4108W3Q	Transcriptional regulator
S7S_08715	ENOG4105EBR	Carboxylesterase
S7S_08720	ENOG4105M85	Bola protein
S7S_08725	ENOG4105C72	UPF0176 protein
S7S_08735	ENOG4105D9P	serine threonine protein kinase
S7S_08740	ENOG4105TMB	Formate nitrite transporter
S7S_08745	ENOG4105D9P	serine threonine protein kinase
S7S_08750	ENOG4107R3J	Transporter
S7S_08755	ENOG4107QZF	nitrite reductase NADPH large subunit
S7S_08760	ENOG4107QZF	nitrite reductase NADPH large subunit
S7S_08765	ENOG4108IFG	nitrite reductase, (NAD(P)H)
S7S_08775	ENOG4105CB8	Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity)
S7S_08805	ENOG4105CDV	Ompa motb domain protein
S7S_08825	ENOG4105BZU	Histidine kinase
S7S_08830	ENOG4105C1G	acyl-Coa dehydrogenase
S7S_08835	ENOG4105C1G	acyl-Coa dehydrogenase
S7S_08840	ENOG4105EMU	Dehydrogenase
S7S_08845	ENOG4105CB3	Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity)
S7S_08850	ENOG4107QP3	malate synthase g
S7S_08870	ENOG4105CZ1	Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity)
S7S_08885	ENOG4105EZE	Cupin 4 family protein
S7S_08890	ENOG4107QTF	adenylosuccinate lyase
S7S_08895	ENOG41075W9	High frequency lysogenization protein HflD homolog
S7S_08900	ENOG4105CCJ	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity)
S7S_08910	ENOG4108YXW	Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
S7S_08915	ENOG4105M00	molybdopterin converting factor, subunit 1
S7S_08920	ENOG4108ZAF	Molybdopterin
S7S_08925	ENOG4108R99	pseudouridine synthase
S7S_08935	ENOG4105VEQ	Cold shock protein
S7S_08945	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
S7S_08950	ENOG4105K9U	however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity)
S7S_08955	ENOG4105DWA	May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate
S7S_08960	ENOG4108R4Z	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity)
S7S_08965	ENOG4105C3M	thioredoxin reductase
S7S_08970	ENOG4105CNU	cell division protein FtsK
S7S_08975	ENOG4107Y7W	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity)
S7S_08980	ENOG4105D1H	recombination factor protein RarA
S7S_08985	ENOG4105CGR	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity)
S7S_08990	ENOG4105CB8	Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity)
S7S_09005	ENOG4108ZAT	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE (By similarity)
S7S_09010	ENOG4108MN8	Membrane
S7S_09020	ENOG41084A1	Protein CrcB homolog
S7S_09025	ENOG4105WMR	Protein CrcB homolog
S7S_09030	ENOG4105WH1	Two component transcriptional regulator luxr family
S7S_09035	ENOG4105CII	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity)
S7S_09040	ENOG4105BZQ	cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase
S7S_09045	ENOG4105BZU	Histidine kinase
S7S_09050	ENOG4105BZU	Histidine kinase
S7S_09055	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
S7S_09060	ENOG4107Z5C	methylesterase
S7S_09065	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
S7S_09070	ENOG4107QHF	type ii secretion system protein e
S7S_09075	ENOG4105D7Q	type ii secretion system
S7S_09080	ENOG4108VAU	general secretion pathway protein G
S7S_09090	ENOG4105X5Z	General secretion pathway protein I
S7S_09095	ENOG4108WWZ	General secretion pathway protein J
S7S_09100	ENOG4108RTD	type II secretion system protein K
S7S_09110	ENOG41064QQ	General secretion pathway
S7S_09130	ENOG4108HRN	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity)
S7S_09145	ENOG4105D64	Mechanosensitive ion channel
S7S_09155	ENOG4105C15	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity)
S7S_09160	ENOG4105W8H	transhydrogenase (subunit alpha
S7S_09165	ENOG4108IIE	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity)
S7S_09185	ENOG4105CN1	protease
S7S_09200	ENOG4107QUT	magnesium and cobalt transport protein CorA
S7S_09205	ENOG4108RW0	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity)
S7S_09215	ENOG4105D1Q	UPF0246 protein
S7S_09235	ENOG4105D4P	Coproporphyrinogen iii oxidase
S7S_09245	ENOG4108MUZ	hydrolase
S7S_09250	ENOG4105DQ4	alcohol dehydrogenase
S7S_09390	ENOG4105C2C	drug resistance transporter, Bcr CflA
S7S_09420	ENOG4105EJ2	Transcriptional regulator
S7S_09425	ENOG4105D6S	protein involved in catabolism of external DNA
S7S_09430	ENOG4108CWB	sugar kinase ygcE
S7S_09435	ENOG4105C6V	Glycerol-3-phosphate dehydrogenase
S7S_09440	ENOG4105CQB	FAD linked oxidase domain protein
S7S_09440	ENOG4105CQB	FAD linked oxidase domain protein
S7S_09455	ENOG4108ZG0	Ompa motb domain protein
S7S_09485	ENOG4107QJE	Chromosome Partitioning Protein
S7S_09495	ENOG4105DC8	reductase
S7S_09500	ENOG4105CBC	glutamate synthase
S7S_09505	ENOG4105E4C	Lytic transglycosylase catalytic
S7S_09520	ENOG4105CF9	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity)
S7S_09525	ENOG4105CF9	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity)
S7S_09550	ENOG4105DXD	2-methylcitrate dehydratase
S7S_09555	ENOG4105C7F	AcnD-accessory protein PrpF
S7S_09560	ENOG4108I0Z	Aconitate hydratase
S7S_09565	ENOG4105BZN	citrate synthase
S7S_09570	ENOG4105CR4	methylisocitrate lyase
S7S_09575	ENOG4105DRR	Transcriptional regulator, GntR family
S7S_09615	ENOG4105ECA	phosphoserine phosphatase homoserine phosphotransferase bifunctional protein
S7S_09625	ENOG4107R11	Transcriptional regulator
S7S_09655	ENOG4105C35	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity)
S7S_09660	ENOG4107QY0	Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity)
S7S_09665	ENOG4108CAF	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity)
S7S_09670	ENOG4106YVY	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) (By similarity)
S7S_09675	ENOG4106YVY	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) (By similarity)
S7S_09680	ENOG4105D8J	Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity)
S7S_09705	ENOG4105CBM	Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity)
S7S_09720	ENOG4107RFD	Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity)
S7S_09725	ENOG4105C6P	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity)
S7S_09730	ENOG4105D3G	Pseudouridine synthase
S7S_09740	ENOG4107QXP	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity)
S7S_09745	ENOG4105CNK	Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity)
S7S_09755	ENOG4107RUK	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins (By similarity)
S7S_09760	ENOG4107QI1	Mate efflux family protein
S7S_09770	ENOG4105ET1	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity)
S7S_09780	ENOG4107RX3	Mg2 transporter protein cora family protein
S7S_09790	ENOG4105ERU	peptidase
S7S_09810	ENOG4107RZZ	dna polymerase iii epsilon subunit
S7S_09815	ENOG4108UMW	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
S7S_09825	ENOG4108RW0	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity)
S7S_09830	ENOG4105E9H	Lytic Murein transglycosylase
S7S_09845	ENOG4108I5X	binding-protein-dependent transport systems inner membrane Component
S7S_09850	ENOG4108IYQ	Binding-protein-dependent transport systems inner membrane component
S7S_09855	ENOG4108JQ5	ABC transporter
S7S_09860	ENOG4105CSJ	Enoyl- acyl-carrier-protein reductase NADH
S7S_09865	ENOG4105EIN	peptidylprolyl cis-trans isomerase
S7S_09870	ENOG4105K70	DNA-binding protein
S7S_09875	ENOG4105C6P	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity)
S7S_09880	ENOG4105CHN	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity)
S7S_09885	ENOG4105CCQ	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity)
S7S_09890	ENOG4105DEA	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation
S7S_09895	ENOG4105CN0	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity)
S7S_09900	ENOG4105CX6	glutaminyL-tRNA synthetase
S7S_09905	ENOG4108R5K	PPIases accelerate the folding of proteins (By similarity)
S7S_09915	ENOG4105F10	Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity)
S7S_09925	ENOG4105FR9	TRNA-(Ms 2 io 6 A)-hydroxylase
S7S_09935	ENOG4107QIJ	Aconitate hydratase 2
S7S_09945	ENOG4105K5B	UPF0225 protein
S7S_09960	ENOG4105D4A	Cell wall formation (By similarity)
S7S_09965	ENOG4105KJF	protein tyrosine phosphatase
S7S_09970	ENOG4105CET	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity)
S7S_09975	ENOG4105CHD	Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity)
S7S_09980	ENOG4105BZ1	(ABC) transporter
S7S_09985	ENOG4109015	Biopolymer transport protein exbD tolR
S7S_09995	ENOG4108EQH	DNA internalization-related competence protein ComEC Rec2
S7S_10010	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
S7S_10015	ENOG4105D60	lipoprotein releasing system transmembrane protein
S7S_10025	ENOG4105DWY	Agmatine deiminase
S7S_10045	ENOG4105EJC	lysr family transcriptional regulator
S7S_10050	ENOG4108QXE	glycerophosphoryl diester phosphodiesterase
S7S_10065	ENOG4105CJ2	(LipO)protein
S7S_10075	ENOG4108IUB	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity)
S7S_10085	ENOG4106I92	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity)
S7S_10095	ENOG4105DWQ	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity)
S7S_10105	ENOG4108RG0	uracil-dna glycosylase
S7S_10110	ENOG4105C29	acyl-CoA thioesterase
S7S_10115	ENOG4108JA2	transcriptioN-repair coupling factor
S7S_10125	ENOG4105CBX	hi0933 family
S7S_10135	ENOG4107RHB	Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates (By similarity)
S7S_10140	ENOG4108UGV	hypoxanthine phosphoribosyltransferase
S7S_10145	ENOG4105D64	Mechanosensitive ion channel
S7S_10150	ENOG4107QPA	Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides (By similarity)
S7S_10155	ENOG4107N1Q	ErfK YbiS YcfS YnhG family protein
S7S_10160	ENOG4105U5Y	Transcriptional regulator
S7S_10175	ENOG4105C73	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity)
S7S_10180	ENOG41081QV	Universal stress protein
S7S_10190	ENOG4105DS7	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity)
S7S_10200	ENOG4105F8V	Hydrolase, tatD family
S7S_10210	ENOG4105C4H	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity)
S7S_10215	ENOG4105WFT	During stationary phase, converts 70S ribosomes to an inactive dimeric form (100S ribosomes) (By similarity)
S7S_10230	ENOG4107SP2	The ortholog in A.thaliana is involved in photosystem II (PSII) assembly, but knockout of the corresponding gene in Synechoccus PCC 7002 has no effect on PSII activity
S7S_10235	ENOG4105D25	secreted protein
S7S_10245	ENOG4105CD8	aminopeptidase N
S7S_10255	ENOG4105F91	Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity)
S7S_10260	ENOG4105EYW	Ion transport protein
S7S_10275	ENOG4108RZE	Tetr family transcriptional regulator
S7S_10290	ENOG4107QX3	carboxylase
S7S_10295	ENOG4105C1G	acyl-Coa dehydrogenase
S7S_10300	ENOG4105E39	Enoyl-CoA hydratase
S7S_10310	ENOG4105J5T	Amp-dependent synthetase and ligase
S7S_10345	ENOG4105CIS	alcohol dehydrogenase
S7S_10350	ENOG4105PFA	Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity)
S7S_10355	ENOG4105DA6	Catalyzes the conversion of 5-methoxyuridine (mo5U) to uridine-5-oxyacetic acid (cmo5U) at position 34 in tRNA. May also participate in the methylation of uridine-5-oxyacetic acid (cmo5U) to uridine-5-oxyacetic acid methyl ester (mcmo5U) (By similarity)
S7S_10360	ENOG4105WJX	transcriptional regulator MERR family
S7S_10365	ENOG4108ZUF	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity)
S7S_10370	ENOG4105C6A	phenylalanyl-tRNA synthetase (beta subunit)
S7S_10375	ENOG4105CSS	phenylalanyl-tRNA synthetase (alpha subunit)
S7S_10380	ENOG4108YZX	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity)
S7S_10385	ENOG41082NX	50s ribosomal protein l35
S7S_10390	ENOG4108UUX	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity)
S7S_10400	ENOG4105CCW	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity)
S7S_10405	ENOG4105CHM	Aminotransferase
S7S_10415	ENOG4105C3T	may be the GTPase, regulating ATP sulfurylase activity (By similarity)
S7S_10420	ENOG4105C11	sulfate adenylyltransferase), subunit 2
S7S_10430	ENOG4107QP8	phosphohexose isomerase
S7S_10435	ENOG4105C6Y	Udp-glucose 6-dehydrogenase
S7S_10440	ENOG4105C3Y	UTP-glucose-1-phosphate uridylyltransferase
S7S_10445	ENOG4107ENK	receptor
S7S_10475	ENOG4107UCJ	Catalyzes the synthesis of activated sulfate (By similarity)
S7S_10510	ENOG4105D3Q	Sugar transferase
S7S_10525	ENOG4105EAG	UDP-N-acetylglucosamine 2-epimerase
S7S_10535	ENOG4105C5E	polysaccharide biosynthesis protein
S7S_10550	ENOG4105EVB	acetyltransferase
S7S_10570	ENOG4107QQG	Dehydrogenase
S7S_10585	ENOG4105DCI	Phosphohydrolase
S7S_10605	ENOG4105CY0	Metallo-Beta-Lactamase
S7S_10640	ENOG4105E5V	Participates in transcription elongation, termination and antitermination (By similarity)
S7S_10645	ENOG4105D75	Capsular exopolysaccharide family
S7S_10655	ENOG4105DAY	polysaccharide export protein
S7S_10660	ENOG4108MRJ	
S7S_10690	ENOG4106EG9	Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity)
S7S_10695	ENOG4105CFV	Tetratricopeptide repeat protein
S7S_10705	ENOG41080YA	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity)
S7S_10710	ENOG4105CAV	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity)
S7S_10715	ENOG4105CAT	Cytidine monophosphate kinase
S7S_10720	ENOG4105CMY	5-enolpyruvylshikimate-3-phosphate synthase
S7S_10725	ENOG4105CIH	Imidazole acetol-phosphate transaminase
S7S_10730	ENOG4105CQC	Prephenate dehydratase
S7S_10735	ENOG4107QM1	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity)
S7S_10740	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
S7S_10745	ENOG4105D6T	Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity)
S7S_10750	ENOG4107RFD	Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity)
S7S_10755	ENOG4108VXP	Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity)
S7S_10760	ENOG4105UBK	short-chain dehydrogenase reductase
S7S_10765	ENOG4108821	RND type efflux pump
S7S_10770	ENOG4108821	RND type efflux pump
S7S_10775	ENOG4105CNK	Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity)
S7S_10785	ENOG4108821	RND type efflux pump
S7S_10800	ENOG4107R6G	Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity)
S7S_10815	ENOG4108ZZ3	UPF0260 protein
S7S_10820	ENOG4105VNG	YcgL domain-containing protein
S7S_10835	ENOG4105DKJ	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
S7S_10880	ENOG4107IFA	Lipase (EC 3.1.1.3)
S7S_10885	ENOG4107IFA	Lipase (EC 3.1.1.3)
S7S_10890	ENOG4108821	RND type efflux pump
S7S_10895	ENOG4108821	RND type efflux pump
S7S_10910	ENOG4105EYM	Major Facilitator superfamily
S7S_10920	ENOG4105EZ6	Catalyzes the 2'-O-methylation at nucleotide C2498 in 23S rRNA (By similarity)
S7S_10930	ENOG4105CIY	formyltetrahydrofolate deformylase
S7S_10935	ENOG4108R6W	Transcriptional regulator, ARAC family
S7S_10940	ENOG4105KF3	Short-chain dehydrogenase reductase Sdr
S7S_10945	ENOG4105EUJ	GTP cyclohydrolase i
S7S_10960	ENOG41080XQ	Signal transduction protein with cbs domains
S7S_10970	ENOG4105CHH	sulfate transporter
S7S_10990	ENOG4105EUB	pirin domain protein
S7S_10995	ENOG4105CKD	glutathione-regulated potassium-efflux system protein
S7S_11005	ENOG4107SVH	Potassium channel protein
S7S_11070	ENOG4105DYT	3-hydroxyacyl-CoA dehydrogenase
S7S_11075	ENOG4105CHU	acetyl-coa acetyltransferase
S7S_11085	ENOG4105S8Q	sugar efflux transporter
S7S_11090	ENOG4105D9I	Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity)
S7S_11155	ENOG4105DBD	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity)
S7S_11165	ENOG4105VM8	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity)
S7S_11170	ENOG4105CFH	Aspartokinase
S7S_11175	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
S7S_11180	ENOG4105Y3E	Modulates RecA activity (By similarity)
S7S_11185	ENOG4105C68	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity)
S7S_11190	ENOG4107TH8	cina domain protein
S7S_11200	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
S7S_11205	ENOG4107RZC	phospholipase d
S7S_11210	ENOG4107RZC	phospholipase d
S7S_11215	ENOG41067SE	Tetr family transcriptional regulator
S7S_11225	ENOG4105E0T	Short-chain dehydrogenase reductase Sdr
S7S_11235	ENOG4107RN6	Monooxygenase
S7S_11240	ENOG4105CJJ	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity)
S7S_11255	ENOG4107Z7P	Ferredoxin
S7S_11265	ENOG4108EQM	faD-dependent pyridine nucleotide-disulfide oxidoreductase
S7S_11280	ENOG4105BZU	Histidine kinase
S7S_11285	ENOG4108ZX5	transcriptional regulator
S7S_11325	ENOG4108KC2	acyl-Coa dehydrogenase
S7S_11330	ENOG4105CC9	acyl-Coa dehydrogenase
S7S_11335	ENOG4105CEY	Amp-dependent synthetase and ligase
S7S_11360	ENOG41064MX	Tetr family transcriptional regulator
S7S_11365	ENOG4105ENT	Efflux transporter rnd family, mfp subunit
S7S_11380	ENOG4105W5Q	DNA repair protein (RadC
S7S_11465	ENOG4105JXR	Protein of unknown function (DUF3296)
S7S_11485	ENOG4105D86	that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity)
S7S_11490	ENOG4108Z4U	Ferredoxin
S7S_11525	ENOG4105CQX	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity)
S7S_11530	ENOG4108Z5K	methylglyoxal synthase
S7S_11540	ENOG4108DG9	Smr protein MutS2
S7S_11545	ENOG4105DX1	Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation (By similarity)
S7S_11560	ENOG4105CI4	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity)
S7S_11570	ENOG4105CXB	phosphoribosylaminoimidazole synthetase
S7S_11575	ENOG4108V3E	phosphoribosylglycinamide formyltransferase
S7S_11590	ENOG4105DHP	deoxycytidine triphosphate deaminase
S7S_11605	ENOG4108ZX5	transcriptional regulator
S7S_11625	ENOG4105BZU	Histidine kinase
S7S_11640	ENOG4105GNX	MltA-interacting MipA family protein
S7S_11655	ENOG4108YZY	peptidylprolyl cis-trans isomerase
S7S_11660	ENOG4105EXW	epimerase dehydratase
S7S_11665	ENOG4105D8J	Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity)
S7S_11670	ENOG4107SC1	transglycosylase
S7S_11675	ENOG4105IH7	synthase
S7S_11680	ENOG4108W1A	pseudouridine synthase
S7S_11690	ENOG4108VWS	Yaeq family
S7S_11705	ENOG4105C3P	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity)
S7S_11720	ENOG4105CYM	Glutathione S-transferase
S7S_11735	ENOG4105DGI	Alkaline phosphatase
S7S_11740	ENOG4105BZU	Histidine kinase
S7S_11745	ENOG4105CKH	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity)
S7S_11755	ENOG4105D3R	alkyl hydroperoxide reductase
S7S_11760	ENOG4108JU3	Alkyl hydroperoxide reductase
S7S_11765	ENOG4108Z0Z	intracellular protease Pfpi family
S7S_11770	ENOG4105CJB	Exodeoxyribonuclease I
S7S_11790	ENOG4105EKE	dihydroorotase
S7S_11795	ENOG4108JJ7	ABC transporter
S7S_11800	ENOG4105DEN	Luciferase family
S7S_11810	ENOG4105E46	N-alpha,N-alpha,N-alpha-trimethyl-L-histidine metabolic process
S7S_11815	ENOG41067HS	methyltransferase
S7S_11840	ENOG4105EGI	Transcriptional regulator
S7S_11850	ENOG4108J2R	molybdopterin oxidoreductase
S7S_11860	ENOG4105DGN	Electron transport complex
S7S_11865	ENOG4108R3D	Electron transport complex
S7S_11875	ENOG4105D6A	Electron transport complex
S7S_11880	ENOG4108UQQ	Electron transport complex
S7S_11885	ENOG4105DZB	Electron transport complex
S7S_11905	ENOG4105CSM	endonuclease III
S7S_11920	ENOG4105D9I	Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity)
S7S_11925	ENOG4105D9I	Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity)
S7S_11935	ENOG4105CDH	Citrulline--aspartate ligase
S7S_11940	ENOG4105DH5	Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity)
S7S_11950	ENOG41076HS	cation diffusion facilitator family transporter
S7S_11955	ENOG4108K5P	(LipO)protein
S7S_11965	ENOG4105E26	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity)
S7S_11970	ENOG4106NZV	Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs (By similarity)
S7S_11975	ENOG4108UH8	Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity)
S7S_11980	ENOG4105CE5	Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity)
S7S_11985	ENOG4105XX3	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity)
S7S_11990	ENOG4105C70	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity)
S7S_11995	ENOG4105CXR	Phospho-2-dehydro-3-deoxyoctonate aldolase
S7S_12000	ENOG4105C8D	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity)
S7S_12005	ENOG4105D3U	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity)
S7S_12010	ENOG4107QM9	Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity)
S7S_12015	ENOG4105D05	Receptor
S7S_12025	ENOG4105C0B	DNA polymerase III (alpha subunit)
S7S_12030	ENOG4108UH2	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
S7S_12035	ENOG4105D0V	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
S7S_12040	ENOG4105DAF	Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
S7S_12045	ENOG4108YXN	Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity)
S7S_12050	ENOG4105D7M	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
S7S_12060	ENOG4105E1Z	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
S7S_12065	ENOG4105DZP	Membrane-associated zinc metalloprotease
S7S_12070	ENOG4105CEA	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity)
S7S_12075	ENOG4105KNE	Phosphatidate cytidylyltransferase
S7S_12080	ENOG4105CR3	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity)
S7S_12085	ENOG4108VCV	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity)
S7S_12090	ENOG4105C41	Catalyzes the reversible phosphorylation of UMP to UDP (By similarity)
S7S_12095	ENOG4105CU7	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity)
S7S_12105	ENOG4105CA1	Removes the N-terminal methionine from nascent proteins (By similarity)
S7S_12110	ENOG4105E1P	Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity)
S7S_12115	ENOG4105CHM	Aminotransferase
S7S_12120	ENOG4105KUZ	arsenate reductase
S7S_12125	ENOG4105EJ3	Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2- amino-6-oxopimelate using succinyl-CoA (By similarity)
S7S_12130	ENOG4105C9Y	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity)
S7S_12145	ENOG4105C3P	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity)
S7S_12160	ENOG4105IUQ	nucleoprotein polynucleotide-associated enzyme
S7S_12165	ENOG4105EZR	dyp-type peroxidase family protein
S7S_12200	ENOG4105DWV	Homoserine O-trans-acetylase
S7S_12215	ENOG4108IG5	Transcriptional regulator
S7S_12225	ENOG4105E55	glycerol-3-phosphate acyltransferase
S7S_12235	ENOG4105FFN	Specifically methylates the guanosine in position 1516 of 16S rRNA (By similarity)
S7S_12240	ENOG4105DWR	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity)
S7S_12250	ENOG41072GX	Peptidase M22 Glycoprotease
S7S_12255	ENOG4105DVT	helicase
S7S_12260	ENOG4105C6R	Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity)
S7S_12270	ENOG4105VJP	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity)
S7S_12275	ENOG4107QMS	site-determining protein
S7S_12280	ENOG4105K7U	Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity)
S7S_12285	ENOG4105CC8	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity)
S7S_12295	ENOG4105KWW	Biogenesis protein
S7S_12300	ENOG4107QX9	Thiol disulfide interChange protein
S7S_12305	ENOG4105DA4	cytochrome c-type biogenesis protein
S7S_12310	ENOG4108RKI	Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length (By similarity)
S7S_12345	ENOG4105DXN	mazG family
S7S_12350	ENOG4105CWR	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity)
S7S_12355	ENOG4105BZT	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity)
S7S_12360	ENOG4105C6T	cysteine synthase
S7S_12365	ENOG4105BZU	Histidine kinase
S7S_12370	ENOG4105KJV	Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity)
S7S_12375	ENOG4105CSZ	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity)
S7S_12390	ENOG41071DT	Involved in DNA repair and RecF pathway recombination (By similarity)
S7S_12395	ENOG4105CWT	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity)
S7S_12400	ENOG4108ZBM	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity)
S7S_12410	ENOG4105C3F	Signal peptidase i
S7S_12415	ENOG4105C4S	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity)
S7S_12420	ENOG4105C0H	protease
S7S_12430	ENOG4105VQK	sigma E regulatory protein, MucB RseB
S7S_12440	ENOG4105EMN	RNA polymerase sigma factor
S7S_12445	ENOG4108IYU	L-aspartate oxidase
S7S_12465	ENOG4106HNH	Acyl-transferase
S7S_12490	ENOG4108IPT	Naphthoate synthase
S7S_12495	ENOG4105CF3	3-Hydroxyisobutyrate dehydrogenase
S7S_12500	ENOG4105C1G	acyl-Coa dehydrogenase
S7S_12505	ENOG4105C26	Dehydrogenase
S7S_12515	ENOG4105D5S	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity)
S7S_12525	ENOG4105CRK	lysyL-tRNA synthetase
S7S_12540	ENOG4105C2R	Single-stranded-DNA-specific exonuclease (RecJ)
S7S_12545	ENOG4105DYT	3-hydroxyacyl-CoA dehydrogenase
S7S_12550	ENOG4105CHU	acetyl-coa acetyltransferase
S7S_12575	ENOG4105C1J	atp-dependent rna helicase
S7S_12590	ENOG4105C57	major facilitator superfamily
S7S_12605	ENOG4107KET	secretion protein, HlyD family
S7S_12645	ENOG410804D	Sensor Signal Transduction Histidine Kinase
S7S_12660	ENOG4105F9N	Major Facilitator Superfamily
S7S_12685	ENOG4105KWI	UPF0339 protein
S7S_12695	ENOG4105C8Q	Methyl-accepting chemotaxis
S7S_12705	ENOG4108V1T	peptidylprolyl cis-trans isomerase
S7S_12710	ENOG4105T95	Thiol disulfide interChange protein
S7S_12720	ENOG4105CMM	transposase
S7S_12760	ENOG4105C0H	protease
S7S_12770	ENOG4108TEM	pseudouridine methyltransferase
S7S_12815	ENOG4108V1T	peptidylprolyl cis-trans isomerase
S7S_12820	ENOG4105T95	Thiol disulfide interChange protein
S7S_12855	ENOG4105JQN	Transcriptional regulator
S7S_12860	ENOG4105EXG	Transcriptional regulator
S7S_12865	ENOG4105DHI	Methyltransferase
S7S_12895	ENOG4105K8R	UPF0145 protein
S7S_12900	ENOG4105K8R	UPF0145 protein
S7S_12910	ENOG4105D3R	alkyl hydroperoxide reductase
S7S_12945	ENOG41088YA	Catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form coenzyme F420-0-glutamyl-glutamate (F420-2) or polyglutamated F420 derivatives (By similarity)
S7S_12990	ENOG4108UPT	UPF0178 protein
S7S_13000	ENOG4105DHQ	Histidine kinase
S7S_13005	ENOG4105CV9	cyclopropane-fatty-acyl-phospholipid synthase
S7S_13035	ENOG4105CDV	Ompa motb domain protein
S7S_13040	ENOG4105CDV	Ompa motb domain protein
S7S_13050	ENOG4105C1G	acyl-Coa dehydrogenase
S7S_13055	ENOG4105C1G	acyl-Coa dehydrogenase
S7S_13080	ENOG4105CCY	NADH flavin oxidoreductase, NADH oxidase
S7S_13090	ENOG4105CHU	acetyl-coa acetyltransferase
S7S_13095	ENOG4105CHR	reductase
S7S_13100	ENOG4108ZX5	transcriptional regulator
S7S_13115	ENOG4105EJ2	Transcriptional regulator
S7S_13130	ENOG4108UK5	Transposase
S7S_13135	ENOG4105D06	uba thif-type nad fad binding protein
S7S_13140	ENOG4105EQY	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity)
S7S_13145	ENOG4105C8K	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity)
S7S_13150	ENOG4105C7E	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity)
S7S_13165	ENOG4105CTR	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity)
S7S_13170	ENOG4105C5T	Phosphoribosyl pyrophosphate synthase
S7S_13175	ENOG4105KW6	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity)
S7S_13180	ENOG4108ZPD	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity)
S7S_13190	ENOG4105C3G	gtp-binding protein
S7S_13195	ENOG4105DFP	Integrase
S7S_13205	ENOG4108I5C	dEAD DEAH box helicase
S7S_13210	ENOG4105BZK	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity)
S7S_13270	ENOG4105DIV	Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD( ) and coenzyme A. Is the final enzyme in the meta- cleavage pathway for the degradation of aromatic compounds (By similarity)
S7S_13275	ENOG4105DF3	Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta-cleavage pathway for the degradation of aromatic compounds (By similarity)
S7S_13290	ENOG4108Q89	anthranilate 1,2-dioxygenase large subunit
S7S_13320	ENOG4107SEV	1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase
S7S_13330	ENOG4105VQD	rieske 2fe-2S domain-containing protein
S7S_13340	ENOG4105P8F	nudix hydrolase
S7S_13345	ENOG4107HP6	Transcriptional regulator
S7S_13355	ENOG4105C26	Dehydrogenase
S7S_13380	ENOG4105BZ9	Cytochrome C oxidase, subunit I
S7S_13385	ENOG4105FT1	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I (By similarity)
S7S_13390	ENOG4107QS1	Cytochrome C Oxidase, Subunit III
S7S_13410	ENOG4107TQK	Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group (By similarity)
S7S_13415	ENOG4105F1R	Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity)
S7S_13420	ENOG4108V0P	LemA family
S7S_13425	ENOG4105D0M	Protease HtpX homolog
S7S_13435	ENOG4105P52	geranylgeranyl reductase
S7S_13440	ENOG4105CV9	cyclopropane-fatty-acyl-phospholipid synthase
S7S_13455	ENOG4107RJ1	sodium solute
S7S_13470	ENOG4105BZU	Histidine kinase
S7S_13500	ENOG4105M78	Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity)
S7S_13505	ENOG4108IAB	Phoh family
S7S_13545	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
S7S_13550	ENOG4108J2H	Sulfate ABC transporter periplasmic sulfate-binding protein
S7S_13555	ENOG4108I5D	sulfate abc transporter
S7S_13560	ENOG4105ECW	sulfate abc transporter
S7S_13565	ENOG4108IJ6	ABC transporter
S7S_13570	ENOG4105C9A	Phoh family
S7S_13575	ENOG4105KGE	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity)
S7S_13580	ENOG4108JU5	Magnesium and cobalt efflux protein
S7S_13595	ENOG4105CE8	Transfers the fatty acyl group on membrane lipoproteins (By similarity)
S7S_13610	ENOG4105C8T	Leucyl-tRNA synthetase
S7S_13620	ENOG4105DJF	DNA polymerase III, delta' subunit
S7S_13635	ENOG4105C2S	Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity)
S7S_13640	ENOG4108Z1W	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity)
S7S_13650	ENOG4108UXA	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity)
S7S_13655	ENOG4105CJN	penicillin-binding protein
S7S_13660	ENOG4105CNI	cell division protein FtsW
S7S_13665	ENOG4105CVE	Lytic murein transglycosylase
S7S_13670	ENOG4105K6T	rare lipoprotein A
S7S_13675	ENOG4105DZ1	carboxypeptidase
S7S_13680	ENOG4105F0I	Aminotransferase
S7S_13690	ENOG4108BDP	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity)
S7S_13695	ENOG4105C0G	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity)
S7S_13720	ENOG4108YZN	class I peptide chain release factor
S7S_13730	ENOG4105C8E	extradiol ring-cleavage dioxygenase class IIi protein subunit b
S7S_13760	ENOG410822N	TonB family
S7S_13770	ENOG4108IJ6	ABC transporter
S7S_13775	ENOG4105ECW	sulfate abc transporter
S7S_13780	ENOG4108I5D	sulfate abc transporter
S7S_13785	ENOG4105DE7	Sulfate ABC transporter periplasmic sulfate-binding protein
S7S_13810	ENOG4108UMA	3-octaprenyl-4-hydroxybenzoate carboxy-lyase
S7S_13820	ENOG4105DFU	Cell wall formation (By similarity)
S7S_13840	ENOG4108IV0	ABC, transporter
S7S_13845	ENOG4105C0Z	ABC transporter
S7S_13850	ENOG4105CNN	ABC, transporter
S7S_13855	ENOG4105CF8	branched-chain amino acid ABC transporter, permease
S7S_13860	ENOG41083Z3	extracellular ligand-binding receptor
S7S_13865	ENOG4105BZU	Histidine kinase
S7S_13870	ENOG4105BZU	Histidine kinase
S7S_13875	ENOG4105CTQ	phosphohexokinase
S7S_13885	ENOG4105C1J	atp-dependent rna helicase
S7S_13895	ENOG4105F0N	pyrophosphate phospho-hydrolase
S7S_13905	ENOG4105YES	addiction module antidote protein
S7S_13910	ENOG4105VUH	addiction module killer protein
S7S_13920	ENOG4105CSG	Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity)
S7S_13925	ENOG4108Z38	Catalyzes a trans-dehydration via an enolate intermediate (By similarity)
S7S_13930	ENOG4105KM4	Acetyl-CoA carboxylase, biotin carboxyl carrier protein
S7S_13935	ENOG4105CER	acetyl-CoA carboxylase biotin carboxylase
S7S_13940	ENOG4105F59	Methylates ribosomal protein L11 (By similarity)
S7S_13950	ENOG4105CEH	Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity)
S7S_13960	ENOG4105DC1	bifunctional purine biosynthesis protein purh
S7S_13965	ENOG4105C12	Phosphoribosylglycinamide synthetase
S7S_13975	ENOG4105BZU	Histidine kinase
S7S_13980	ENOG4108ZX5	transcriptional regulator
S7S_13985	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
S7S_13990	ENOG4108S0N	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol (By similarity)
S7S_14005	ENOG4105FDS	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity)
S7S_14015	ENOG4108UKZ	OsmC family
S7S_14020	ENOG4107RYR	Transcriptional regulator, Crp Fnr family
S7S_14035	ENOG4108Z4X	TRANSCRIPTIONal
S7S_14040	ENOG41062YB	Trap dicarboxylate transporter, dctp subunit
S7S_14045	ENOG4105F35	Catalyzes the NAD( )-dependent oxidation of L-carnitine to 3-dehydrocarnitine (By similarity)
S7S_14050	ENOG4105CG6	trap dicarboxylate transporter dctm subunit
S7S_14065	ENOG410811B	TRANSCRIPTIONal
S7S_14075	ENOG4108YYC	ycei family
S7S_14080	ENOG4105E0F	Histidine kinase
S7S_14120	ENOG4105GRZ	Ycii-related protein
S7S_14125	ENOG4105CHP	RNA polymerase
S7S_14150	ENOG4105DK0	Indole-3-glycerol phosphate synthase
S7S_14155	ENOG4108I0Q	anthranilate phosphoribosyltransferase
S7S_14160	ENOG4105DDQ	anthranilate synthase
S7S_14170	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
S7S_14180	ENOG4105GR3	Histidine kinase
S7S_14185	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
S7S_14225	ENOG4105JDN	Copper resistance protein
S7S_14235	ENOG4106NZI	LysR family Transcriptional regulator
S7S_14245	ENOG4105W1Y	Transcriptional regulator
S7S_14255	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
S7S_14265	ENOG4107QJE	Chromosome Partitioning Protein
S7S_14305	ENOG4105C73	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity)
S7S_14410	ENOG4107QKA	exodeoxyribonuclease V beta
S7S_14465	ENOG4105W5Q	DNA repair protein (RadC
S7S_14500	ENOG4108R8Z	these effects are overcome by concomitant expression of antitoxin SohA (PrlF). Massive overexpression is toxic. Unlike most other characterized TA systems degrades rRNA, and co-folding of the proteins is necessary in vitro for inhibition of the RNase activity. It is not known if it has any sequence-specificity. Acts as a transcription factor. The YhaV PrlF complex binds the prlF-yhaV operon, probably negatively regulating its expression
S7S_14525	ENOG4105DFP	Integrase
S7S_14530	ENOG4105CRQ	synthase (Component I)
S7S_14535	ENOG4105EIF	outer membrane protein W
S7S_14560	ENOG4105DN4	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
S7S_14570	ENOG4105D7B	Flagellar biosynthesis protein flha
S7S_14580	ENOG4105D00	flagellar biosynthetic protein flhB
S7S_14585	ENOG4108KCC	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P) (By similarity)
S7S_14590	ENOG4108VYJ	response regulator receiver protein
S7S_14595	ENOG4105C8Q	Methyl-accepting chemotaxis
S7S_14600	ENOG4105CMP	catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity)
S7S_14605	ENOG4105BZU	Histidine kinase
S7S_14610	ENOG4107RHT	methyl-accepting chemotaxis sensory transducer with Pas Pac sensor
S7S_14615	ENOG4108V3W	Chemotaxis protein, CheW
S7S_14620	ENOG4105CBS	Chea signal transduction histidine kinase
S7S_14625	ENOG4105ER2	Ompa motb domain protein
S7S_14630	ENOG4107RD7	Flagellar Motor Protein, MotA
S7S_14635	ENOG4106CIA	Functions in complex with FlhD as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region
S7S_14640	ENOG4105GEH	Functions in complex with FlhC as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region. Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes. Also regulates genes whose products function in a variety of physiological pathways (By similarity)
S7S_14645	ENOG4105VM1	flagellar
S7S_14660	ENOG4105MQ3	flagellar protein FliS
S7S_14665	ENOG4105DTS	flagellar hook-associated
S7S_14670	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
S7S_14685	ENOG41063QE	flagellar protein FlaG
S7S_14690	ENOG4105VQ0	flagellar hook-basal body complex protein fliE
S7S_14695	ENOG4105C1F	The M ring may be actively involved in energy transduction (By similarity)
S7S_14700	ENOG4105CS3	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity)
S7S_14705	ENOG41090PJ	Flagellar assembly protein
S7S_14710	ENOG4108JIR	Flagellum-specific ATP synthase
S7S_14730	ENOG4105D24	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity)
S7S_14735	ENOG4105DD5	Flagellar motor switch protein
S7S_14745	ENOG4105CN7	Flagellar biosynthetic protein FliP
S7S_14750	ENOG4105VS8	Flagellar biosynthetic protein fliq
S7S_14755	ENOG4105D19	Role in flagellar biosynthesis (By similarity)
S7S_14770	ENOG4105DTJ	flagellar hook-associated protein
S7S_14775	ENOG4105E1Q	flagellar hook-associated protein
S7S_14780	ENOG4108ZW7	flagellar rod assembly protein muramidase flgj
S7S_14785	ENOG4105D92	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity)
S7S_14795	ENOG4105CGA	flagellar basal-body rod protein FlgG
S7S_14800	ENOG4108KPB	Flagellar basal-body rod protein FlgF
S7S_14805	ENOG4105BZE	flagellar hook protein, FlgE
S7S_14810	ENOG4105W00	Flagellar hook capping protein
S7S_14815	ENOG4108ZC9	flagellar basal-body rod protein flgc
S7S_14820	ENOG4105K88	Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity)
S7S_14840	ENOG4108Z7T	Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity)
S7S_14850	ENOG4107YPT	transcriptional regulator
S7S_14865	ENOG4105BZ9	Cytochrome C oxidase, subunit I
S7S_14870	ENOG4105CV4	Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity)
S7S_14895	ENOG4105DJV	ribulose-phosphate 3-epimerase
S7S_14900	ENOG4108S0S	Nucleotidyl transferase
S7S_14905	ENOG4105EHM	Aminoglycoside phosphotransferase
S7S_14910	ENOG4105E7H	involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity)
S7S_14915	ENOG4105DBD	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity)
S7S_14920	ENOG4105CEZ	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity)
S7S_14925	ENOG4105D1X	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity)
S7S_14930	ENOG4105NWN	ApaG protein
S7S_14935	ENOG4105DDT	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity)
S7S_14940	ENOG4105CYN	Serine protein kinase
S7S_14945	ENOG4106AKX	UPF0229 protein
S7S_14950	ENOG4105ED1	spovr family
S7S_14955	ENOG4105EA8	2-Nitropropane dioxygenase
S7S_14970	ENOG4105D4J	Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate
S7S_14975	ENOG4107EXU	Short-chain dehydrogenase reductase Sdr
S7S_14990	ENOG4107RN6	Monooxygenase
S7S_15000	ENOG4105K8U	2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
S7S_15005	ENOG4107ZVW	dihydroneopterin aldolase
S7S_15010	ENOG4105K7Z	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity)
S7S_15015	ENOG4105CPM	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
S7S_15020	ENOG4105VCC	30S ribosomal protein S21
S7S_15030	ENOG4105C9G	DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity)
S7S_15045	ENOG4105BZU	Histidine kinase
S7S_15080	ENOG4107S76	domain protein
S7S_15085	ENOG4105F2V	VRR-NUC domain-containing protein
S7S_15095	ENOG4105E99	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity)
S7S_15100	ENOG4105PDP	Short chain dehydrogenase
S7S_15110	ENOG4108YY7	Invasion gene expression up-regulator SirB
S7S_15125	ENOG4105HEI	LysR family (Transcriptional regulator
S7S_15130	ENOG4105F27	Major Facilitator
S7S_15135	ENOG4105CV8	reductase
S7S_15155	ENOG4105EUS	Binding-protein-dependent transport systems, inner membrane component
S7S_15175	ENOG4105RWS	endonuclease I
S7S_15180	ENOG4105CSU	acyl-Coa dehydrogenase
S7S_15185	ENOG4105CSU	acyl-Coa dehydrogenase
S7S_15190	ENOG4105W49	UPF0434 protein
S7S_15195	ENOG4105HDD	phospholipase
S7S_15220	ENOG4105KJP	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
S7S_15280	ENOG4107RN6	Monooxygenase
S7S_15315	ENOG4108MGY	Histidine kinase
S7S_15320	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
S7S_15325	ENOG4107KBT	8-Amino-7-oxononanoate synthase
S7S_15340	ENOG4105DR5	peptidase
S7S_15345	ENOG4105DHT	Metal Dependent Phosphohydrolase
S7S_15350	ENOG4105C22	threonyL-tRNA synthetase
S7S_15355	ENOG4105K8F	Phosphoribosyl-amp cyclohydrolase
S7S_15360	ENOG4105C8N	cysteinyl-tRNA synthetase
S7S_15365	ENOG4105EM2	membrane
S7S_15370	ENOG4105VAS	Could be involved in insertion of integral membrane proteins into the membrane (By similarity)
S7S_15380	ENOG4105UGU	tonB-dependent Receptor
S7S_15400	ENOG4105DZA	Converts GTP to 7,8-dihydroneopterin triphosphate (By similarity)
S7S_15415	ENOG4108JPW	Aminotransferase
S7S_15420	ENOG4108Z6K	Catalyzes the circularization of gamma-N-acetyl- alpha,gamma-diaminobutyric acid (ADABA) to ectoine (1,4,5,6- tetrahydro-2-methyl-4-pyrimidine carboxylic acid), which is an excellent osmoprotectant (By similarity)
S7S_15440	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
S7S_15450	ENOG4105CSH	Transporter
S7S_15460	ENOG4105BZU	Histidine kinase
S7S_15470	ENOG4108RBP	3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity)
S7S_15480	ENOG4107QN1	sodium solute
S7S_15505	ENOG4105CTB	Polyprenyl synthetase
S7S_15510	ENOG4105C2V	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity)
S7S_15535	ENOG4105BZU	Histidine kinase
S7S_15540	ENOG4108ZAI	phosphatidylglycerophosphatase a
S7S_15545	ENOG4105CG2	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity)
S7S_15550	ENOG4107YIM	Involved in the transcription termination process (By similarity)
S7S_15555	ENOG4108UTT	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity)
S7S_15560	ENOG4105C3A	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs) (By similarity)
S7S_15565	ENOG4105DJ9	glucan biosynthesis protein
S7S_15570	ENOG4108YXG	UPF0502 protein
S7S_15575	ENOG4105C66	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity)
S7S_15585	ENOG4105D1W	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity)
S7S_15590	ENOG4108Z11	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity)
S7S_15595	ENOG4105C65	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity)
S7S_15605	ENOG4105C5H	ABC transporter
S7S_15625	ENOG4105DNJ	May play a role in the repair of endogenous alkylation damage (By similarity)
S7S_15630	ENOG4105CJ4	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity)
S7S_15635	ENOG4105CDU	Replicative dna helicase
S7S_15640	ENOG4105CV9	cyclopropane-fatty-acyl-phospholipid synthase
S7S_15660	ENOG4105ETT	transcriptional Regulator, LysR family
S7S_15665	ENOG4105K9Q	Binds to the 23S rRNA (By similarity)
S7S_15670	ENOG4105VH8	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity)
S7S_15680	ENOG4108ZDX	Binds together with S18 to 16S ribosomal RNA (By similarity)
S7S_15695	ENOG4105C2N	RNA methyltransferase TrmH family group 3
S7S_15700	ENOG4105C40	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity)
S7S_15720	ENOG4105C91	Plays an important role in the de novo pathway of purine nucleotide biosynthesis
S7S_15725	ENOG4105C49	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity)
S7S_15735	ENOG4105EPW	hflc protein
S7S_15740	ENOG4107QJR	hflk protein
S7S_15745	ENOG4105C1N	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity)
S7S_15750	ENOG4105KW8	RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity)
S7S_15765	ENOG4105DC6	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity)
S7S_15770	ENOG4105C5C	n-acetylmuramoyl-l-alanine amidase
S7S_15775	ENOG4105K8N	protein family UPF0079, ATPase
S7S_15780	ENOG4105DR1	Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity)
S7S_15785	ENOG4105EH2	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity)
S7S_15810	ENOG4108RBP	3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity)
S7S_15820	ENOG4105E06	May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity)
S7S_15825	ENOG4105KHC	sulfurtransferase
S7S_15830	ENOG4105DJ4	phosphatidylserine decarboxylase
S7S_15845	ENOG4105EAC	phosphoserine phosphatase
S7S_15850	ENOG4105BZU	Histidine kinase
S7S_15860	ENOG4105CK3	Lysine 2,3-aminomutase YodO family protein
S7S_15865	ENOG4105DRH	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity)
S7S_15870	ENOG4105CAP	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P (By similarity)
S7S_15875	ENOG4105CP9	extracellular ligand-binding receptor
S7S_15890	ENOG4105PW4	Sugar fermentation stimulation protein homolog
S7S_15905	ENOG4108V7X	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
S7S_15910	ENOG4106F3G	Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity)
S7S_15920	ENOG4105BZU	Histidine kinase
S7S_15925	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
S7S_15930	ENOG4105DJ0	Poly(A) Polymerase
S7S_15935	ENOG4105K8U	2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
S7S_15945	ENOG4105CCG	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity)
S7S_15950	ENOG4108IAA	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity)
S7S_15955	ENOG4108Z2X	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity)
S7S_15960	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
S7S_15970	ENOG41090WB	Transposase is3 is911
S7S_15980	ENOG4105VJY	transcriptional regulator
S7S_15985	ENOG4105F27	Major Facilitator
S7S_16025	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
S7S_16035	ENOG4105CA1	Removes the N-terminal methionine from nascent proteins (By similarity)
S7S_16040	ENOG4108KF1	Membrane
S7S_16080	ENOG4108Q2J	Inner membrane protein YebE
S7S_16085	ENOG4105C1G	acyl-Coa dehydrogenase
S7S_16125	ENOG4105KA7	cytochrome C
S7S_16170	ENOG4105C5H	ABC transporter
S7S_16175	ENOG4105DZG	Dehydrogenase
S7S_16190	ENOG4105C8Q	Methyl-accepting chemotaxis
S7S_16200	ENOG4105CHM	Aminotransferase
S7S_16205	ENOG4105CZ7	nitrilase cyanide hydratase and apolipoprotein n-acyltransferase
S7S_16210	ENOG4108RBJ	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity)
S7S_16215	ENOG4107XGF	functions in a salvage pathway. Uses pyridoxamine (By similarity)
S7S_16220	ENOG4105VEQ	Cold shock protein
S7S_16225	ENOG4108KPJ	rna polymerase sigma factor
S7S_16270	ENOG4108UM6	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity)
S7S_16275	ENOG4105CY8	phosphoribosylaminoimidazole carboxylase atpase subunit
S7S_16290	ENOG4105C1G	acyl-Coa dehydrogenase
S7S_16295	ENOG4105KF3	Short-chain dehydrogenase reductase Sdr
S7S_16310	ENOG4108I7Y	domain protein
S7S_16320	ENOG4105DDY	UPF0142 protein ycaO
S7S_16340	ENOG4105DEF	Extracellular solute-binding protein, family 5
S7S_16350	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
S7S_16365	ENOG41074FZ	May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity)
S7S_16370	ENOG4107RAW	3-carboxy-cis-cis-muconate cycloisomerase
S7S_16405	ENOG4105C4R	Atp-dependent dna helicase
S7S_16415	ENOG4105EKQ	RNA-directed DNA polymerase
S7S_16425	ENOG4106H6R	UPF0380 protein
S7S_16470	ENOG4105C62	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity)
S7S_16475	ENOG4105K77	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity)
S7S_16480	ENOG4105D0T	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity)
S7S_16485	ENOG4105KG7	Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity)
S7S_16490	ENOG4107QHU	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity)
S7S_16495	ENOG4105CHV	Transcription elongation factor NusA
S7S_16500	ENOG4105K7D	Required for maturation of 30S ribosomal subunits (By similarity)
S7S_16505	ENOG4107EJC	Preprotein translocase subunit SecG
S7S_16510	ENOG4105CP7	Triose-phosphate isomerase
S7S_16515	ENOG4107QJF	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity)
S7S_16520	ENOG4105EEI	dihydropteroate synthase
S7S_16525	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
S7S_16530	ENOG4105F7M	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity)
S7S_16535	ENOG4105HBR	Rna-binding protein
S7S_16540	ENOG4108UKH	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity)
S7S_16545	ENOG4105CU6	carbamoyl-phosphate synthetase ammonia chain
S7S_16550	ENOG4105C1M	carbamoyl-phosphate synthetase glutamine chain
S7S_16555	ENOG4105DUK	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity)
S7S_16560	ENOG4105KJM	monovalent cation h antiporter subunit g
S7S_16565	ENOG4105W4C	monovalent cation H antiporter subunit F
S7S_16575	ENOG4107R4Z	monovalent cation h antiporter subunit d
S7S_16580	ENOG4108ZE9	Monovalent cation H antiporter subunit C
S7S_16585	ENOG4105D65	subunit l
S7S_16590	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
S7S_16595	ENOG4105CFG	Acts as a chaperone (By similarity)
S7S_16600	ENOG4105K90	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
S7S_16605	ENOG4105CI8	Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity)
S7S_16610	ENOG4105C4F	May be involved in recombinational repair of damaged DNA (By similarity)
S7S_16615	ENOG41090R7	Ferric uptake
S7S_16620	ENOG4105YRI	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity)
S7S_16625	ENOG4105VDB	UPF0125 protein
S7S_16630	ENOG4105C8J	)-transporter
S7S_16635	ENOG4108UH4	Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity)
S7S_16665	ENOG4105CMM	transposase
S7S_16685	ENOG4108Z3N	Transcriptional regulator
S7S_16695	ENOG4105DU1	integral membrane protein, terc
S7S_16715	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
S7S_16725	ENOG4105E8V	Alpha Beta Hydrolase Fold protein
S7S_16730	ENOG4108VKV	Monofunctional biosynthetic peptidoglycan transglycosylase
S7S_16735	ENOG4107EII	Lipoprotein involved with copper homeostasis and adhesion
S7S_16740	ENOG4108UJE	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity)
S7S_16750	ENOG4105CAA	catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity)
S7S_16760	ENOG41068B1	Cob-I-yrinic acid a,c-diamide adenosyltransferase
S7S_16765	ENOG4108IPX	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity)
S7S_16770	ENOG4105EHG	Permease protein
S7S_16775	ENOG4105JKQ	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity)
S7S_16780	ENOG4105CHI	Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity)
S7S_16790	ENOG4105EFT	decarboxylase
S7S_16795	ENOG4105DH2	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity)
S7S_16800	ENOG4105CUP	Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity)
S7S_16810	ENOG4105GN9	Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity)
S7S_16820	ENOG4108YZT	Adenosylcobinamide kinase
S7S_16845	ENOG4107RET	Isocitrate lyase
S7S_16850	ENOG4105CVM	Molybdenum cofactor synthesis domain protein
S7S_16855	ENOG4108RIR	Molybdenum cofactor biosynthesis protein
S7S_16865	ENOG4108RIR	Molybdenum cofactor biosynthesis protein
S7S_16870	ENOG4107R3N	Filamentation induced by cAMP protein fic
S7S_16875	ENOG4105C5X	domain protein
S7S_16900	ENOG4108YXI	Secondary thiamine-phosphate synthase enzyme
S7S_16905	ENOG4105C5I	Dehydrogenase
S7S_16915	ENOG4108ZYK	Acyl carrier protein phosphodiesterase
S7S_16920	ENOG4105DP5	Catalyzes the biosynthesis of agmatine from arginine (By similarity)
S7S_16925	ENOG4105CCX	Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity)
S7S_16935	ENOG4105MDH	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity)
S7S_16940	ENOG4105CT3	Monooxygenase
S7S_16950	ENOG4108W0I	acetyltransferase
S7S_16970	ENOG4108PTX	LysR family Transcriptional regulator
S7S_16975	ENOG4105C1G	acyl-Coa dehydrogenase
S7S_16990	ENOG4106HB6	Alpha beta hydrolase
S7S_17005	ENOG4105K85	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity)
S7S_17030	ENOG41084HI	prevent-host-death family
S7S_17065	ENOG4108YZA	Nitrogen regulatory protein pii
S7S_17070	ENOG4105W0Z	cytoplasmic protein
S7S_17080	ENOG4105C0P	Mg chelatase subunit ChlI
S7S_17095	ENOG4105I7Z	Short-chain dehydrogenase reductase Sdr
S7S_17100	ENOG4105C4R	Atp-dependent dna helicase
S7S_17115	ENOG4105MPD	Cytochrome
S7S_17140	ENOG4105CCG	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity)
S7S_17145	ENOG4105CA9	Pyruvate kinase
S7S_17160	ENOG4105PE1	Receptor
S7S_17175	ENOG4105D8V	Glucose sorbosone dehydrogenase
S7S_17200	ENOG4105CHQ	Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity)
S7S_17210	ENOG4107QWP	ABC-2 type transporter
S7S_17215	ENOG4105CJ1	ABC, transporter
S7S_17225	ENOG4105U5Y	Transcriptional regulator
S7S_17230	ENOG4105EWI	Short-chain dehydrogenase reductase Sdr
S7S_17260	ENOG41082AG	Plasmid maintenance system antidote protein
S7S_17280	ENOG4105CHR	reductase
S7S_17285	ENOG4105DMT	epimerase dehydratase
S7S_17290	ENOG4105C09	Bile acid
S7S_17295	ENOG4105H3G	oxidoreductase
S7S_17310	ENOG41063TF	transcriptional regulator (AraC
S7S_17320	ENOG4105D29	Helix-turn-helix type 11 domain protein
S7S_17330	ENOG4108UKI	Enoyl-CoA hydratase
S7S_17335	ENOG4108IJ8	ABC transporter
S7S_17340	ENOG4105EHV	domain protein
S7S_17350	ENOG4105CH6	catalase
S7S_17355	ENOG4105M2E	Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity)
S7S_17360	ENOG4108V1J	Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity)
S7S_17385	ENOG4108UT2	hemolysin iii
S7S_17390	ENOG4105CS1	NAD(P)H quinone oxidoreductase
S7S_17410	ENOG4107RN6	Monooxygenase
S7S_17415	ENOG4108KEZ	Dehydrogenase
S7S_17430	ENOG4105E0X	reductase
S7S_17440	ENOG41080HT	Transcriptional regulator, arsr family
S7S_17465	ENOG4107YPT	transcriptional regulator
S7S_17510	ENOG41061ZR	Transcriptional regulator
S7S_17525	ENOG41067MG	lrgb family
S7S_17535	ENOG4105DND	Transcriptional regulator
S7S_17550	ENOG4107E2E	PKHD-type hydroxylase
S7S_17585	ENOG4107QYX	exodeoxyribonuclease v alpha
S7S_17590	ENOG4107QKA	exodeoxyribonuclease V beta
S7S_17595	ENOG4105DSY	exodeoxyribonuclease V, gamma
S7S_17610	ENOG4106RE7	Cytochrome
S7S_17615	ENOG4105MPD	Cytochrome
S7S_17620	ENOG4105WHM	Necessary for normal cell division and for the maintenance of normal septation (By similarity)
S7S_17625	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
S7S_17630	ENOG4105C2M	dna polymerase I
S7S_17640	ENOG4105YA8	Transcriptional regulator
S7S_17665	ENOG4105FDK	ABC transporter
S7S_17670	ENOG4105FAV	ABC, transporter
S7S_17715	ENOG4107QZF	nitrite reductase NADPH large subunit
S7S_17720	ENOG4105VCQ	rubredoxin
S7S_17725	ENOG4105VEI	Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4- hydroxybenzoate (4HB) for the ubiquinone pathway (By similarity)
S7S_17730	ENOG4105C4G	Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity)
S7S_17735	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
S7S_17740	ENOG4105BZU	Histidine kinase
S7S_17755	ENOG41069P5	Protein slyX homolog
S7S_17765	ENOG4105CAU	Arsenical resistance protein, ArsH
S7S_17770	ENOG4105D6J	arsenicaL-resistance protein
S7S_17775	ENOG4108UXE	Protein tyrosine phosphatase
S7S_17780	ENOG41082YX	Transcriptional regulator, arsr family
S7S_17785	ENOG4108UTW	Plays a role in the regulation of phosphate uptake
S7S_17790	ENOG4105BZY	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity)
S7S_17800	ENOG4105C8U	phosphate abc transporter
S7S_17810	ENOG4105NAU	thioesterase Superfamily protein
S7S_17820	ENOG4105DWV	Homoserine O-trans-acetylase
S7S_17825	ENOG4105DWV	Homoserine O-trans-acetylase
S7S_17830	ENOG4108V82	Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity)
S7S_17840	ENOG4105CSA	Coproporphyrinogen iii oxidase
S7S_17850	ENOG4105ENT	Efflux transporter rnd family, mfp subunit
S7S_17855	ENOG4105BZS	acriflavin resistance protein
S7S_17865	ENOG4107TVK	Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity)
S7S_17895	ENOG4105DS1	cytochrome b561
S7S_17915	ENOG4105CMP	catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity)
S7S_17920	ENOG4105CBS	Chea signal transduction histidine kinase
S7S_17925	ENOG4105BZU	Histidine kinase
S7S_17930	ENOG4105C8Q	Methyl-accepting chemotaxis
S7S_17935	ENOG4108ZGA	chew protein
S7S_17940	ENOG4105M3Z	response regulator
S7S_17945	ENOG4108UNF	response regulator
S7S_17950	ENOG4105D7Z	glutathione synthase
S7S_17960	ENOG4108UJU	UPF0301 protein
S7S_17965	ENOG4107Y66	Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity)
S7S_17975	ENOG4105CXT	aspartate transcarbamylase
S7S_17980	ENOG4105CD3	dihydroorotase
S7S_17985	ENOG4105CHH	sulfate transporter
S7S_18030	ENOG4105CHF	Glutathione S-transferase
S7S_18035	ENOG4105EUB	pirin domain protein
S7S_18040	ENOG4107QWG	2-Nitropropane dioxygenase
S7S_18045	ENOG4105CZX	twitching motility protein
S7S_18050	ENOG4105CZX	twitching motility protein
S7S_18055	ENOG4105DFA	alanine racemase domain protein
S7S_18060	ENOG4105II7	pyrroline-5-carboxylate reductase
S7S_18065	ENOG4108VIA	integral membrane protein
S7S_18070	ENOG4105VZ9	UPF0235 protein
S7S_18075	ENOG4105C4R	Atp-dependent dna helicase
S7S_18080	ENOG4105BZU	Histidine kinase
S7S_18085	ENOG41084S7	Plasmid maintenance system antidote protein
S7S_18095	ENOG4108V3G	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity)
S7S_18100	ENOG4105ETT	transcriptional Regulator, LysR family
S7S_18105	ENOG4105CJW	magnesium transporter
S7S_18110	ENOG4105ENJ	RND efflux system, outer membrane lipoprotein
S7S_18115	ENOG4105BZS	acriflavin resistance protein
S7S_18120	ENOG4105BZS	acriflavin resistance protein
S7S_18170	ENOG4105SG9	biopolymer transport protein, ExbD
S7S_18175	ENOG4105E02	MotA TolQ exbB proton channel
S7S_18190	ENOG4108SF5	RNA Polymerase
S7S_18225	ENOG4105C46	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity)
S7S_18230	ENOG4105CAJ	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity)
S7S_18235	ENOG4105KNM	Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity)
S7S_18240	ENOG4105C4J	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity)
S7S_18245	ENOG4105J80	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity)
S7S_18250	ENOG4105CDG	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity)
S7S_18255	ENOG4107S15	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
S7S_18260	ENOG4107Z6K	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
S7S_18265	ENOG4105KY6	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
S7S_18270	ENOG4105EE4	it plays a direct role in the translocation of protons across the membrane (By similarity)
S7S_18280	ENOG4105CSH	Transporter
S7S_18285	ENOG4105E2S	oxidase) subunit II
S7S_18290	ENOG4105BZ9	Cytochrome C oxidase, subunit I
S7S_18295	ENOG4105CCU	oxidase (Subunit III)
S7S_18300	ENOG41090KH	cytochrome o ubiquinol oxidase (subunit iv)
S7S_18310	ENOG4105EB3	Histidine kinase
S7S_18315	ENOG4108UYB	regulatoR
S7S_18345	ENOG4105FA0	parb-like partition protein
S7S_18350	ENOG4107QJE	Chromosome Partitioning Protein
S7S_18355	ENOG4105D28	Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity)
S7S_18360	ENOG4107RE5	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity)
S7S_18365	ENOG4105C3N	Participates in control of cell volume in low-osmolarity conditions (By similarity)
S7S_18370	ENOG4105CSU	acyl-Coa dehydrogenase
S7S_18380	ENOG4105C0D	helicase
S7S_18385	ENOG4105BZU	Histidine kinase
S7S_18390	ENOG4108IXY	short-chain dehydrogenase reductase
S7S_18395	ENOG4105D8T	Acyltransferase
S7S_18400	ENOG4107QX8	SPFH domain, Band 7 family protein
S7S_18410	ENOG4105VEQ	Cold shock protein
S7S_18415	ENOG41082IR	Excinuclease ABC C subunit domain protein
S7S_18430	ENOG4105BZK	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity)
S7S_18455	ENOG4105D82	Glutamate dehydrogenase
S7S_18475	ENOG4105CEY	Amp-dependent synthetase and ligase
S7S_18480	ENOG4105C9Q	fumarate hydratase class II
S7S_18490	ENOG4105BZU	Histidine kinase
S7S_18495	ENOG4108MGY	Histidine kinase
S7S_18525	ENOG4105C3X	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity)
S7S_18555	ENOG4105C1H	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity)
S7S_18560	ENOG4105DHW	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
S7S_18565	ENOG4105NVJ	RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity)
S7S_18570	ENOG4105VG0	50S ribosomal protein l34