locus-tag	class	description
S7S_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
S7S_00020	COG0187	DNA topoisomerase II activity
S7S_00045	COG0751	glycine-tRNA ligase activity
S7S_00050	COG0752	glycyl-tRNA synthetase alpha subunit
S7S_00055	COG0519	Catalyzes the synthesis of GMP from XMP
S7S_00085	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
S7S_00090	COG1295	ribonuclease BN
S7S_00105	COG1960	acyl-CoA dehydrogenase activity
S7S_00115	COG2186	Transcriptional regulator
S7S_00120	COG3239	Fatty acid desaturase
S7S_00130	COG0569	domain protein
S7S_00135	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
S7S_00140	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
S7S_00145	COG0242	peptide deformylase activity
S7S_00155	COG0758	DNA mediated transformation
S7S_00160	COG0009	L-threonylcarbamoyladenylate synthase
S7S_00165	COG0408	coproporphyrinogen oxidase activity
S7S_00170	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
S7S_00180	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
S7S_00185	COG0339	signal peptide processing
S7S_00195	COG3609	addiction module antidote protein, CC2985 family
S7S_00220	COG3239	Fatty acid desaturase
S7S_00245	COG0326	Molecular chaperone. Has ATPase activity
S7S_00255	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
S7S_00260	COG0583	DNA-binding transcription factor activity
S7S_00275	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
S7S_00280	COG1758	RNA polymerase activity
S7S_00285	COG0194	GDP metabolic process
S7S_00295	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
S7S_00335	COG0789	Transcriptional regulator
S7S_00340	COG0745	RESPONSE REGULATOR receiver
S7S_00345	COG2205	protein histidine kinase activity
S7S_00350	COG2433	Pfam Transposase IS66
S7S_00370	COG1561	YicC-like family, N-terminal region
S7S_00375	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
S7S_00380	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
S7S_00390	COG1309	transcriptional regulator
S7S_00395	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
S7S_00405	COG0756	dUTP diphosphatase activity
S7S_00410	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
S7S_00415	COG2003	Belongs to the UPF0758 family
S7S_00420	COG0227	Belongs to the bacterial ribosomal protein bL28 family
S7S_00435	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
S7S_00440	COG4149	molybdate abc transporter
S7S_00445	COG0725	ABC transporter, periplasmic molybdate-binding protein
S7S_00465	COG4964	Belongs to the GSP D family
S7S_00515	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
S7S_00540	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
S7S_00545	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
S7S_00560	COG1309	transcriptional regulator
S7S_00575	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
S7S_00580	COG0583	DNA-binding transcription factor activity
S7S_00590	COG0436	Aminotransferase
S7S_00620	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
S7S_00650	COG0742	ribosomal rna small subunit methyltransferase
S7S_00655	COG0612	Peptidase, M16
S7S_00660	COG0612	Peptidase, M16
S7S_00665	COG0552	protein localization to endoplasmic reticulum
S7S_00670	COG2884	Cell division ATP-binding protein ftsE
S7S_00675	COG2177	Part of the ABC transporter FtsEX involved in
S7S_00685	COG2363	Small membrane protein
S7S_00695	COG2022	thiamine diphosphate biosynthetic process
S7S_00705	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
S7S_00715	COG2974	May be involved in recombination
S7S_00730	COG0220	tRNA (guanine-N7-)-methyltransferase activity
S7S_00740	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
S7S_00745	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
S7S_00750	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
S7S_00760	COG1309	transcriptional regulator
S7S_00765	COG0500	methyltransferase
S7S_00850	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
S7S_00855	COG0126	phosphoglycerate kinase activity
S7S_00905	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
S7S_00910	COG0277	FAD linked oxidase domain protein
S7S_00915	COG0179	Fumarylacetoacetate (FAA) hydrolase
S7S_00925	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
S7S_00930	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
S7S_00940	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
S7S_00955	COG3079	Belongs to the UPF0149 family
S7S_00960	COG0006	proline dipeptidase activity
S7S_00965	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
S7S_00970	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
S7S_00980	COG2171	N-acyltransferase activity
S7S_01020	COG0404	The glycine cleavage system catalyzes the degradation of glycine
S7S_01025	COG0509	glycine decarboxylation via glycine cleavage system
S7S_01030	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
S7S_01035	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
S7S_01050	COG1959	2 iron, 2 sulfur cluster binding
S7S_01085	COG1024	Enoyl-CoA hydratase
S7S_01095	COG0560	Phosphoserine phosphatase
S7S_01100	COG0494	nUDIX hydrolase
S7S_01120	COG0730	response to heat
S7S_01125	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
S7S_01130	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
S7S_01155	COG4256	Hemin uptake protein
S7S_01195	COG0288	reversible hydration of carbon dioxide
S7S_01210	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
S7S_01220	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
S7S_01230	COG0628	permease
S7S_01235	COG0003	Pfam Anion-transporting ATPase
S7S_01245	COG1966	Carbon starvation protein
S7S_01265	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
S7S_01280	COG0165	Argininosuccinate lyase
S7S_01285	COG3275	phosphorelay sensor kinase activity
S7S_01315	COG0004	ammonium transporteR
S7S_01325	COG4191	Histidine kinase
S7S_01330	COG2204	response regulator
S7S_01340	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
S7S_01345	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
S7S_01350	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
S7S_01355	COG1011	Hydrolase
S7S_01360	COG0494	nUDIX hydrolase
S7S_01365	COG1218	3'(2'),5'-bisphosphate nucleotidase
S7S_01380	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
S7S_01395	COG2814	Major facilitator Superfamily
S7S_01410	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
S7S_01415	COG1194	a g-specific adenine glycosylase
S7S_01435	COG0131	Imidazoleglycerol-phosphate dehydratase
S7S_01440	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
S7S_01445	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
S7S_01455	COG0107	imidazoleglycerol-phosphate synthase activity
S7S_01460	COG0385	Bile acid
S7S_01465	COG2861	carbohydrate metabolic process
S7S_01470	COG0793	Belongs to the peptidase S41A family
S7S_01475	COG4942	peptidase
S7S_01480	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
S7S_01490	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
S7S_01495	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
S7S_01505	COG0189	ligase activity
S7S_01505	COG4067	protein conserved in archaea
S7S_01515	COG0189	ligase activity
S7S_01520	COG3083	sulfuric ester hydrolase activity
S7S_01545	COG0482	sulfurtransferase activity
S7S_01550	COG0425	Belongs to the sulfur carrier protein TusA family
S7S_01550	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
S7S_01555	COG0174	glutamine synthetase
S7S_01565	COG3852	Histidine kinase
S7S_01585	COG1490	D-aminoacyl-tRNA deacylase activity
S7S_01610	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
S7S_01615	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
S7S_01620	COG0140	phosphoribosyl-ATP diphosphatase activity
S7S_01625	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
S7S_01635	COG2226	methyltransferase
S7S_01645	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
S7S_01650	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
S7S_01660	COG0018	arginyl-trna synthetase
S7S_01665	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
S7S_01670	COG0254	rRNA binding
S7S_01675	COG0281	malic enzyme
S7S_01710	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
S7S_01715	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
S7S_01725	COG0070	glutamate synthase
S7S_01725	COG0069	glutamate synthase activity
S7S_01725	COG0067	glutamate synthase
S7S_01730	COG0493	'glutamate synthase
S7S_01735	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
S7S_01760	COG2154	pterin-4-alpha-carbinolamine dehydratase
S7S_01775	COG2045	Belongs to the ComB family
S7S_01785	COG1040	competence protein
S7S_01790	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
S7S_01795	COG0156	8-amino-7-oxononanoate synthase activity
S7S_01800	COG0596	Alpha beta hydrolase
S7S_01805	COG2226	methyltransferase
S7S_01810	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
S7S_01840	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
S7S_01860	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
S7S_01875	COG0471	metal ion transport
S7S_01875	COG3273	potassium ion transport
S7S_01900	COG2132	Multicopper oxidase
S7S_01915	COG4771	TonB-dependent receptor
S7S_01930	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
S7S_01935	COG2862	Uncharacterized protein family, UPF0114
S7S_01940	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
S7S_01940	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
S7S_01950	COG1309	transcriptional regulator
S7S_01965	COG0625	glutathione transferase activity
S7S_01975	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
S7S_01980	COG0672	)-iron permease
S7S_01990	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
S7S_01995	COG0789	Transcriptional regulator
S7S_02000	COG1230	cation diffusion facilitator family transporter
S7S_02005	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
S7S_02030	COG0248	Ppx GppA phosphatase
S7S_02045	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
S7S_02055	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
S7S_02065	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
S7S_02070	COG0488	(ABC) transporter
S7S_02100	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
S7S_02110	COG2918	glutathione biosynthetic process
S7S_02115	COG2183	response to ionizing radiation
S7S_02130	COG0745	RESPONSE REGULATOR receiver
S7S_02145	COG2197	response regulator
S7S_02160	COG2205	protein histidine kinase activity
S7S_02170	COG1252	NADH dehydrogenase
S7S_02175	COG0181	hydroxymethylbilane synthase activity
S7S_02195	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
S7S_02220	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
S7S_02220	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
S7S_02225	COG0306	phosphate transporter
S7S_02230	COG1392	Phosphate transport regulator
S7S_02235	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
S7S_02240	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
S7S_02250	COG0859	PFAM glycosyl transferase family 9
S7S_02255	COG0859	PFAM glycosyl transferase family 9
S7S_02260	COG0438	transferase activity, transferring glycosyl groups
S7S_02275	COG3562	capsule polysaccharide
S7S_02290	COG0297	glycogen (starch) synthase activity
S7S_02295	COG1560	Kdo2-lipid A biosynthetic process
S7S_02310	COG1560	Kdo2-lipid A biosynthetic process
S7S_02315	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
S7S_02315	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
S7S_02320	COG0667	Aldo Keto reductase
S7S_02330	COG1519	Transferase
S7S_02335	COG1538	Outer membrane efflux protein
S7S_02340	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
S7S_02345	COG0494	nUDIX hydrolase
S7S_02355	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
S7S_02360	COG3150	esterase
S7S_02385	COG1187	pseudouridine synthase activity
S7S_02410	COG2003	Belongs to the UPF0758 family
S7S_02415	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
S7S_02445	COG2010	Cytochrome c
S7S_02460	COG3278	Belongs to the heme-copper respiratory oxidase family
S7S_02480	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
S7S_02485	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
S7S_02495	COG2161	toxin-antitoxin pair type II binding
S7S_02500	COG4115	mRNA cleavage
S7S_02570	COG1674	ftsk spoiiie
S7S_02570	COG0433	COG0433 Predicted ATPase
S7S_02595	COG4245	von Willebrand factor, type A
S7S_02615	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
S7S_02620	COG0352	thiamine-phosphate diphosphorylase activity
S7S_02625	COG0352	thiamine-phosphate diphosphorylase activity
S7S_02625	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
S7S_02625	COG0351	phosphomethylpyrimidine kinase
S7S_02635	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
S7S_02650	COG0316	Belongs to the HesB IscA family
S7S_02660	COG3530	Putative quorum-sensing-regulated virulence factor
S7S_02665	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
S7S_02670	COG0739	heme binding
S7S_02675	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
S7S_02680	COG2801	Transposase and inactivated derivatives
S7S_02685	COG2963	transposase activity
S7S_02705	COG0439	Biotin carboxylase
S7S_02720	COG0559	Belongs to the binding-protein-dependent transport system permease family
S7S_02735	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
S7S_02740	COG0410	ABC transporter
S7S_02760	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
S7S_02770	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
S7S_02785	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
S7S_02790	COG0081	regulation of translation
S7S_02800	COG0222	ribosome binding
S7S_02805	COG0085	RNA polymerase activity
S7S_02810	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
S7S_02815	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
S7S_02820	COG0049	tRNA binding
S7S_02825	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
S7S_02830	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
S7S_02835	COG0051	transcription antitermination factor activity, RNA binding
S7S_02840	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
S7S_02845	COG0088	Forms part of the polypeptide exit tunnel
S7S_02850	COG0089	rRNA binding
S7S_02855	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
S7S_02860	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
S7S_02865	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
S7S_02870	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
S7S_02875	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
S7S_02880	COG0255	Belongs to the universal ribosomal protein uL29 family
S7S_02885	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
S7S_02890	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
S7S_02895	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
S7S_02900	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
S7S_02905	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
S7S_02910	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
S7S_02915	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
S7S_02920	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
S7S_02925	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
S7S_02930	COG1841	ribosomal large subunit assembly
S7S_02935	COG0200	Binds to the 23S rRNA
S7S_02945	COG0257	Belongs to the bacterial ribosomal protein bL36 family
S7S_02955	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
S7S_02960	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
S7S_02965	COG0202	RNA polymerase activity
S7S_02970	COG0203	ribosomal protein L17
S7S_02985	COG2197	response regulator
S7S_02990	COG2814	Major facilitator Superfamily
S7S_03050	COG4221	oxidoreductase activity
S7S_03065	COG4221	oxidoreductase activity
S7S_03080	COG0778	Nitroreductase
S7S_03095	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
S7S_03115	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
S7S_03165	COG0142	geranyltranstransferase activity
S7S_03170	COG0261	This protein binds to 23S rRNA in the presence of protein L20
S7S_03175	COG0211	Belongs to the bacterial ribosomal protein bL27 family
S7S_03180	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
S7S_03185	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
S7S_03190	COG0268	Binds directly to 16S ribosomal RNA
S7S_03195	COG0728	peptidoglycan biosynthetic process
S7S_03200	COG0196	riboflavin kinase activity
S7S_03205	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
S7S_03210	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
S7S_03215	COG1047	Peptidyl-prolyl cis-trans
S7S_03220	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
S7S_03285	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
S7S_03285	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
S7S_03315	COG0028	Belongs to the TPP enzyme family
S7S_03360	COG1917	Cupin 2, conserved barrel domain protein
S7S_03360	COG2207	Transcriptional regulator
S7S_03385	COG2801	Transposase and inactivated derivatives
S7S_03450	COG5507	3-demethylubiquinone-9 3-methyltransferase
S7S_03460	COG0583	DNA-binding transcription factor activity
S7S_03465	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
S7S_03470	COG1183	phosphatidylcholine synthase activity
S7S_03480	COG2433	Pfam Transposase IS66
S7S_03530	COG1309	transcriptional regulator
S7S_03535	COG0525	valine-tRNA ligase activity
S7S_03550	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
S7S_03555	COG0795	lipopolysaccharide-transporting ATPase activity
S7S_03560	COG0795	lipopolysaccharide-transporting ATPase activity
S7S_03570	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
S7S_03575	COG0343	queuine tRNA-ribosyltransferase activity
S7S_03580	COG1862	Preprotein translocase
S7S_03590	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
S7S_03595	COG0436	Aminotransferase
S7S_03605	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
S7S_03615	COG0473	3-isopropylmalate dehydrogenase activity
S7S_03650	COG1104	cysteine desulfurase activity
S7S_03665	COG3842	ATPase activity
S7S_03670	COG1176	ABC-type spermidine putrescine transport system, permease component I
S7S_03675	COG1177	transmembrane transport
S7S_03680	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
S7S_03705	COG2166	iron-sulfur cluster assembly
S7S_03715	COG0316	Belongs to the HesB IscA family
S7S_03725	COG0719	Fe-S assembly protein
S7S_03730	COG0396	ATPase activity
S7S_03735	COG0719	Fe-S assembly protein
S7S_03740	COG0105	UTP biosynthetic process
S7S_03745	COG0820	rRNA (adenine-C2-)-methyltransferase activity
S7S_03760	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
S7S_03765	COG0124	histidyl-tRNA synthetase
S7S_03770	COG2976	Protein conserved in bacteria
S7S_03780	COG1160	GTP binding
S7S_03795	COG0784	Response regulator, receiver
S7S_03795	COG2205	protein histidine kinase activity
S7S_03800	COG1570	exodeoxyribonuclease VII activity
S7S_03810	COG0518	GMP synthase (glutamine-hydrolyzing) activity
S7S_03810	COG0519	Catalyzes the synthesis of GMP from XMP
S7S_03820	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
S7S_03835	COG0625	glutathione transferase activity
S7S_03875	COG1307	EDD domain protein, DegV family
S7S_03885	COG0583	DNA-binding transcription factor activity
S7S_03890	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
S7S_03895	COG1597	lipid kinase activity
S7S_03930	COG2807	transmembrane transport
S7S_03945	COG0745	RESPONSE REGULATOR receiver
S7S_03950	COG2205	protein histidine kinase activity
S7S_03970	COG1881	PFAM PEBP family protein
S7S_04010	COG3784	Protein of unknown function (DUF1318)
S7S_04015	COG0861	Integral membrane protein TerC family
S7S_04030	COG0667	Aldo Keto reductase
S7S_04035	COG0583	DNA-binding transcription factor activity
S7S_04045	COG4325	translation initiation factor activity
S7S_04060	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
S7S_04065	COG4977	sequence-specific DNA binding
S7S_04085	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
S7S_04090	COG0590	tRNA wobble adenosine to inosine editing
S7S_04095	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
S7S_04100	COG0047	phosphoribosylformylglycinamidine synthase activity
S7S_04100	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
S7S_04125	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
S7S_04140	COG0735	belongs to the Fur family
S7S_04145	COG0523	cobalamin synthesis protein
S7S_04170	COG1752	Esterase of the alpha-beta hydrolase superfamily
S7S_04180	COG4536	flavin adenine dinucleotide binding
S7S_04190	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
S7S_04195	COG0228	four-way junction DNA binding
S7S_04200	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
S7S_04205	COG0336	Belongs to the RNA methyltransferase TrmD family
S7S_04210	COG0335	large ribosomal subunit rRNA binding
S7S_04215	COG2261	transglycosylase associated protein
S7S_04230	COG0436	Aminotransferase
S7S_04240	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
S7S_04285	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
S7S_04295	COG1804	L-carnitine dehydratase bile acid-inducible protein F
S7S_04310	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
S7S_04340	COG0583	DNA-binding transcription factor activity
S7S_04345	COG1741	Belongs to the pirin family
S7S_04350	COG2259	Doxx family
S7S_04365	COG3608	succinylglutamate desuccinylase aspartoacylase
S7S_04380	COG4953	penicillin-binding protein 1C
S7S_04385	COG1132	(ABC) transporter
S7S_04405	COG1131	(ABC) transporter
S7S_04410	COG0842	Transport permease protein
S7S_04415	COG1196	nuclear chromosome segregation
S7S_04415	COG3264	Mechanosensitive ion channel
S7S_04430	COG5285	phytanoyl-CoA dioxygenase
S7S_04455	COG1024	Enoyl-CoA hydratase
S7S_04460	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
S7S_04465	COG0154	amidase activity
S7S_04470	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
S7S_04475	COG1077	Cell shape determining protein MreB Mrl
S7S_04480	COG1792	Involved in formation and maintenance of cell shape
S7S_04485	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
S7S_04490	COG0424	maF-like protein
S7S_04500	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
S7S_04505	COG0312	modulator of DNA gyrase
S7S_04510	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
S7S_04515	COG3028	Belongs to the UPF0307 family
S7S_04520	COG0312	modulator of DNA gyrase
S7S_04530	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
S7S_04535	COG1660	Displays ATPase and GTPase activities
S7S_04555	COG1137	ATPase activity
S7S_04590	COG5007	Belongs to the BolA IbaG family
S7S_04595	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
S7S_04600	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
S7S_04605	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
S7S_04610	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
S7S_04615	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
S7S_04625	COG1597	lipid kinase activity
S7S_04635	COG2945	thiolester hydrolase activity
S7S_04640	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
S7S_04645	COG1960	acyl-CoA dehydrogenase activity
S7S_04685	COG1233	COG1233 Phytoene dehydrogenase and related
S7S_04695	COG0667	Aldo Keto reductase
S7S_04705	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
S7S_04710	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
S7S_04715	COG0723	plastoquinol--plastocyanin reductase activity
S7S_04720	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
S7S_04725	COG2857	Cytochrome c1
S7S_04730	COG0625	glutathione transferase activity
S7S_04735	COG2969	positive regulation of protein catabolic process
S7S_04745	COG2823	Periplasmic or secreted lipoprotein
S7S_04755	COG0792	nuclease activity
S7S_04765	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
S7S_04770	COG2001	Belongs to the MraZ family
S7S_04775	COG0275	rRNA processing
S7S_04790	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
S7S_04795	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
S7S_04800	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
S7S_04805	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
S7S_04810	COG0772	Belongs to the SEDS family
S7S_04815	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
S7S_04820	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
S7S_04825	COG1181	Belongs to the D-alanine--D-alanine ligase family
S7S_04830	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
S7S_04840	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
S7S_04855	COG0739	heme binding
S7S_04860	COG0653	protein targeting
S7S_04870	COG0352	thiamine-phosphate diphosphorylase activity
S7S_04875	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
S7S_04880	COG0237	dephospho-CoA kinase activity
S7S_04885	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
S7S_04910	COG2755	lipolytic protein G-D-S-L family
S7S_04910	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
S7S_04960	COG1115	amino acid carrier protein
S7S_04970	COG3023	N-Acetylmuramoyl-L-alanine amidase
S7S_04985	COG0508	dehydrogenase complex catalyzes the overall conversion of
S7S_04995	COG0745	RESPONSE REGULATOR receiver
S7S_05000	COG2205	protein histidine kinase activity
S7S_05010	COG2096	Adenosyltransferase
S7S_05015	COG4206	TonB-dependent receptor
S7S_05020	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
S7S_05030	COG2223	nitrite transmembrane transporter activity
S7S_05035	COG3695	enzyme binding
S7S_05040	COG1028	Short-chain dehydrogenase reductase Sdr
S7S_05045	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
S7S_05050	COG0459	protein refolding
S7S_05060	COG3119	arylsulfatase activity
S7S_05080	COG4585	Histidine kinase
S7S_05085	COG2197	response regulator
S7S_05125	COG3437	response regulator, receiver
S7S_05125	COG2205	protein histidine kinase activity
S7S_05125	COG4999	Histidine kinase
S7S_05125	COG3850	Histidine kinase
S7S_05160	COG2205	protein histidine kinase activity
S7S_05165	COG2205	protein histidine kinase activity
S7S_05170	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
S7S_05175	COG2824	Alkylphosphonate utilization operon protein PhnA
S7S_05230	COG0534	Mate efflux family protein
S7S_05240	COG4221	oxidoreductase activity
S7S_05245	COG2072	flavoprotein involved in K transport
S7S_05290	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
S7S_05315	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
S7S_05335	COG0318	PFAM AMP-dependent synthetase and ligase
S7S_05355	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
S7S_05365	COG1309	transcriptional regulator
S7S_05425	COG0642	Histidine kinase
S7S_05430	COG0745	RESPONSE REGULATOR receiver
S7S_05440	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
S7S_05470	COG0183	Belongs to the thiolase family
S7S_05475	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
S7S_05490	COG0582	viral genome integration into host DNA
S7S_05530	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
S7S_05540	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
S7S_05555	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
S7S_05585	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
S7S_05625	COG3657	addiction module killer protein
S7S_05630	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
S7S_05670	COG0217	transcriptional regulatory protein
S7S_05680	COG1960	acyl-CoA dehydrogenase activity
S7S_05720	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
S7S_05730	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
S7S_05745	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
S7S_05765	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
S7S_05790	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
S7S_05820	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
S7S_05820	COG4651	solute:proton antiporter activity
S7S_05830	COG2076	Multidrug Resistance protein
S7S_05835	COG1012	belongs to the aldehyde dehydrogenase family
S7S_05850	COG2076	Multidrug Resistance protein
S7S_05860	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
S7S_05865	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
S7S_05865	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
S7S_05870	COG0745	RESPONSE REGULATOR receiver
S7S_05875	COG2205	protein histidine kinase activity
S7S_05880	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
S7S_05885	COG3706	GGDEF domain
S7S_05905	COG3842	ATPase activity
S7S_05910	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
S7S_05915	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
S7S_05930	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
S7S_05955	COG1960	acyl-CoA dehydrogenase activity
S7S_06000	COG1320	monovalent cation:proton antiporter activity
S7S_06005	COG2212	antiporter activity
S7S_06025	COG2111	Na H antiporter
S7S_06035	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
S7S_06040	COG0714	Associated with various cellular activities
S7S_06075	COG1393	Belongs to the ArsC family
S7S_06080	COG1295	ribonuclease BN
S7S_06080	COG1959	2 iron, 2 sulfur cluster binding
S7S_06085	COG1254	Belongs to the acylphosphatase family
S7S_06115	COG2801	Transposase and inactivated derivatives
S7S_06135	COG0514	ATP-dependent DNA helicase (RecQ)
S7S_06150	COG2072	flavoprotein involved in K transport
S7S_06155	COG0300	oxidoreductase activity
S7S_06175	COG2259	Doxx family
S7S_06180	COG2860	membrane
S7S_06185	COG2226	methyltransferase
S7S_06215	COG1960	acyl-CoA dehydrogenase activity
S7S_06220	COG1192	Involved in chromosome partitioning
S7S_06230	COG0442	prolyl-tRNA aminoacylation
S7S_06245	COG0729	surface antigen
S7S_06260	COG2226	methyltransferase
S7S_06275	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
S7S_06290	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
S7S_06295	COG0217	transcriptional regulatory protein
S7S_06300	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
S7S_06305	COG0632	four-way junction helicase activity
S7S_06310	COG2255	four-way junction helicase activity
S7S_06315	COG0824	Thioesterase
S7S_06335	COG0823	Involved in the tonB-independent uptake of proteins
S7S_06340	COG2885	chlorophyll binding
S7S_06345	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
S7S_06350	COG0602	queuosine metabolic process
S7S_06355	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
S7S_06365	COG0789	Transcriptional regulator
S7S_06370	COG0415	Belongs to the DNA photolyase family
S7S_06390	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
S7S_06395	COG0513	Belongs to the DEAD box helicase family
S7S_06400	COG4783	chaperone-mediated protein folding
S7S_06405	COG0425	Belongs to the sulfur carrier protein TusA family
S7S_06415	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
S7S_06420	COG2716	regulation of RNA biosynthetic process
S7S_06425	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
S7S_06435	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
S7S_06440	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
S7S_06450	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
S7S_06465	COG0789	Transcriptional regulator
S7S_06485	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
S7S_06495	COG3115	cell septum assembly
S7S_06500	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
S7S_06525	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
S7S_06530	COG0583	DNA-binding transcription factor activity
S7S_06540	COG4585	Histidine kinase
S7S_06575	COG0318	PFAM AMP-dependent synthetase and ligase
S7S_06580	COG2301	Belongs to the HpcH HpaI aldolase family
S7S_06590	COG2079	MmgE PrpD family protein
S7S_06600	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
S7S_06605	COG1804	L-carnitine dehydratase bile acid-inducible protein F
S7S_06630	COG2030	dehydratase
S7S_06650	COG0318	PFAM AMP-dependent synthetase and ligase
S7S_06665	COG1024	Enoyl-CoA hydratase
S7S_06670	COG1028	Short-chain dehydrogenase reductase Sdr
S7S_06680	COG0183	Belongs to the thiolase family
S7S_06685	COG1960	acyl-CoA dehydrogenase activity
S7S_06700	COG0318	PFAM AMP-dependent synthetase and ligase
S7S_06720	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
S7S_06730	COG2072	flavoprotein involved in K transport
S7S_06745	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
S7S_06745	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
S7S_06770	COG1028	Short-chain dehydrogenase reductase Sdr
S7S_06805	COG0587	DNA-directed DNA polymerase activity
S7S_06870	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
S7S_06885	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
S7S_06895	COG2271	Major facilitator Superfamily
S7S_06910	COG4133	protoheme IX ABC transporter activity
S7S_06930	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
S7S_06935	COG2906	2 iron, 2 sulfur cluster binding
S7S_06945	COG1802	Transcriptional regulator
S7S_06970	COG1063	alcohol dehydrogenase
S7S_06975	COG0633	Ferredoxin
S7S_06975	COG0543	2 iron, 2 sulfur cluster binding
S7S_07000	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
S7S_07025	COG2356	endonuclease I
S7S_07045	COG2433	Pfam Transposase IS66
S7S_07065	COG3630	sodium ion export across plasma membrane
S7S_07070	COG5016	pyruvate
S7S_07070	COG0511	ligase activity, forming carbon-carbon bonds
S7S_07085	COG0583	DNA-binding transcription factor activity
S7S_07100	COG1131	(ABC) transporter
S7S_07105	COG0842	Transport permease protein
S7S_07110	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
S7S_07110	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
S7S_07120	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
S7S_07130	COG0778	Nitroreductase
S7S_07185	COG1028	Short-chain dehydrogenase reductase Sdr
S7S_07190	COG1028	Short-chain dehydrogenase reductase Sdr
S7S_07205	COG0784	Response regulator, receiver
S7S_07205	COG2205	protein histidine kinase activity
S7S_07235	COG1012	belongs to the aldehyde dehydrogenase family
S7S_07240	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
S7S_07250	COG0450	alkyl hydroperoxide reductase
S7S_07255	COG4772	TonB-dependent receptor
S7S_07260	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
S7S_07265	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
S7S_07270	COG1309	transcriptional regulator
S7S_07290	COG0824	Thioesterase
S7S_07295	COG1454	alcohol dehydrogenase
S7S_07315	COG4585	Histidine kinase
S7S_07325	COG1960	acyl-CoA dehydrogenase activity
S7S_07330	COG3118	belongs to the thioredoxin family
S7S_07350	COG2832	Protein of unknown function (DUF454)
S7S_07360	COG0427	acetyl-CoA hydrolase
S7S_07365	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
S7S_07420	COG3300	MHYT domain
S7S_07420	COG5001	Diguanylate cyclase
S7S_07425	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
S7S_07430	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
S7S_07435	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
S7S_07440	COG1960	acyl-CoA dehydrogenase activity
S7S_07450	COG3101	peptidyl-lysine hydroxylation
S7S_07500	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
S7S_07515	COG0501	Belongs to the peptidase M48B family
S7S_07530	COG0436	Aminotransferase
S7S_07535	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
S7S_07540	COG2818	Glycosylase
S7S_07555	COG2366	antibiotic biosynthetic process
S7S_07595	COG3047	cAMP biosynthetic process
S7S_07595	COG2885	chlorophyll binding
S7S_07605	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
S7S_07610	COG4988	ABC transporter
S7S_07620	COG1294	oxidase, subunit
S7S_07625	COG4890	Cyd operon protein YbgT
S7S_07635	COG0189	ligase activity
S7S_07635	COG4067	protein conserved in archaea
S7S_07650	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
S7S_07655	COG4181	ATPase activity
S7S_07675	COG1196	nuclear chromosome segregation
S7S_07680	COG0204	Acyl-transferase
S7S_07685	COG1804	L-carnitine dehydratase bile acid-inducible protein F
S7S_07700	COG2350	Protein conserved in bacteria
S7S_07705	COG2917	probably involved in intracellular septation
S7S_07710	COG0613	PHP domain protein
S7S_07715	COG0009	L-threonylcarbamoyladenylate synthase
S7S_07720	COG0180	Tryptophanyl-tRNA synthetase
S7S_07730	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
S7S_07745	COG2885	chlorophyll binding
S7S_07745	COG3047	cAMP biosynthetic process
S7S_07825	COG0750	zinc metalloprotease
S7S_07830	COG1643	Atp-dependent helicase
S7S_07870	COG3220	belongs to the UPF0276 family
S7S_07880	COG2853	Lipoprotein
S7S_07895	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
S7S_07900	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
S7S_07910	COG0745	RESPONSE REGULATOR receiver
S7S_07930	COG1022	Amp-dependent synthetase and ligase
S7S_07945	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
S7S_07960	COG0647	UMP catabolic process
S7S_07965	COG2084	Dehydrogenase
S7S_07980	COG2009	succinate dehydrogenase
S7S_07985	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
S7S_07990	COG1053	succinate dehydrogenase
S7S_08015	COG0045	succinate-CoA ligase (ADP-forming) activity
S7S_08040	COG1090	epimerase
S7S_08045	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
S7S_08080	COG0708	Exodeoxyribonuclease III
S7S_08120	COG0745	RESPONSE REGULATOR receiver
S7S_08130	COG0300	oxidoreductase activity
S7S_08135	COG1301	dicarboxylic acid transport
S7S_08150	COG0004	ammonium transporteR
S7S_08160	COG2890	protein-(glutamine-N5) methyltransferase activity
S7S_08165	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
S7S_08180	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
S7S_08185	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
S7S_08200	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
S7S_08205	COG0066	3-isopropylmalate dehydratase activity
S7S_08210	COG0473	3-isopropylmalate dehydrogenase activity
S7S_08230	COG0101	tRNA pseudouridine synthase activity
S7S_08235	COG0135	phosphoribosylanthranilate isomerase activity
S7S_08240	COG0133	tryptophan synthase activity
S7S_08245	COG0159	tryptophan synthase activity
S7S_08250	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
S7S_08255	COG0285	dihydrofolate synthase activity
S7S_08265	COG1286	toxin biosynthetic process
S7S_08280	COG0714	Associated with various cellular activities
S7S_08295	COG3123	guanosine phosphorylase activity
S7S_08300	COG1643	Atp-dependent helicase
S7S_08380	COG1530	ribonuclease E activity
S7S_08395	COG0616	signal peptide processing
S7S_08395	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
S7S_08400	COG3023	N-Acetylmuramoyl-L-alanine amidase
S7S_08405	COG0424	maF-like protein
S7S_08410	COG1399	metal-binding, possibly nucleic acid-binding protein
S7S_08415	COG0333	Belongs to the bacterial ribosomal protein bL32 family
S7S_08420	COG0416	fatty acid biosynthetic process
S7S_08435	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
S7S_08440	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
S7S_08445	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
S7S_08450	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
S7S_08455	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
S7S_08470	COG0084	hydrolase, TatD family'
S7S_08475	COG1322	Protein conserved in bacteria
S7S_08490	COG1104	cysteine desulfurase activity
S7S_08515	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
S7S_08520	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
S7S_08530	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
S7S_08530	COG3153	acetyltransferase
S7S_08535	COG3549	Plasmid maintenance system killer
S7S_08565	COG4195	phage-related replication protein
S7S_08570	COG2433	Pfam Transposase IS66
S7S_08595	COG0330	HflC and HflK could
S7S_08615	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
S7S_08625	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
S7S_08635	COG1024	Enoyl-CoA hydratase
S7S_08640	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
S7S_08645	COG1960	acyl-CoA dehydrogenase activity
S7S_08665	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
S7S_08685	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
S7S_08690	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
S7S_08695	COG0039	L-malate dehydrogenase activity
S7S_08705	COG2207	Transcriptional regulator
S7S_08715	COG2272	Belongs to the type-B carboxylesterase lipase family
S7S_08720	COG0271	Belongs to the BolA IbaG family
S7S_08730	COG3707	response regulator
S7S_08735	COG0515	serine threonine protein kinase
S7S_08735	COG2815	serine threonine protein kinase
S7S_08740	COG2116	formate transmembrane transporter activity
S7S_08745	COG0515	serine threonine protein kinase
S7S_08745	COG2815	serine threonine protein kinase
S7S_08750	COG2223	nitrite transmembrane transporter activity
S7S_08755	COG2146	nitrite reductase [NAD(P)H] activity
S7S_08755	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
S7S_08760	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
S7S_08760	COG2146	nitrite reductase [NAD(P)H] activity
S7S_08765	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
S7S_08770	COG0243	molybdopterin cofactor binding
S7S_08775	COG1648	precorrin-2 dehydrogenase activity
S7S_08775	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
S7S_08825	COG3706	GGDEF domain
S7S_08825	COG0745	RESPONSE REGULATOR receiver
S7S_08830	COG1960	acyl-CoA dehydrogenase activity
S7S_08835	COG1960	acyl-CoA dehydrogenase activity
S7S_08840	COG4221	oxidoreductase activity
S7S_08845	COG0037	tRNA processing
S7S_08850	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
S7S_08870	COG0220	tRNA (guanine-N7-)-methyltransferase activity
S7S_08885	COG2850	peptidyl-arginine hydroxylation
S7S_08895	COG2915	High frequency lysogenization protein hflD homolog
S7S_08900	COG0482	sulfurtransferase activity
S7S_08910	COG0315	cyclic pyranopterin monophosphate synthase activity
S7S_08915	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
S7S_08920	COG0314	molybdopterin synthase activity
S7S_08935	COG1278	Cold shock
S7S_08945	COG0542	response to heat
S7S_08950	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
S7S_08955	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
S7S_08960	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
S7S_08965	COG0492	ferredoxin-NADP+ reductase activity
S7S_08975	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
S7S_08980	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
S7S_08985	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
S7S_08990	COG1648	precorrin-2 dehydrogenase activity
S7S_08990	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
S7S_09005	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
S7S_09020	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
S7S_09025	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
S7S_09035	COG0322	excinuclease ABC activity
S7S_09040	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
S7S_09045	COG0784	Response regulator, receiver
S7S_09045	COG5002	protein histidine kinase activity
S7S_09050	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
S7S_09055	COG3437	response regulator, receiver
S7S_09065	COG3437	response regulator, receiver
S7S_09080	COG2165	general secretion pathway protein
S7S_09130	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
S7S_09130	COG0574	Belongs to the PEP-utilizing enzyme family
S7S_09140	COG0646	methionine synthase
S7S_09140	COG1410	methionine synthase
S7S_09145	COG0668	transmembrane transport
S7S_09155	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
S7S_09160	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
S7S_09165	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
S7S_09190	COG0700	Nucleoside recognition
S7S_09200	COG0598	Magnesium transport protein CorA
S7S_09205	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
S7S_09215	COG3022	response to hydroperoxide
S7S_09230	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
S7S_09245	COG2267	carboxylic ester hydrolase activity
S7S_09250	COG1064	alcohol dehydrogenase
S7S_09390	COG2814	Major facilitator Superfamily
S7S_09410	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
S7S_09420	COG1309	transcriptional regulator
S7S_09425	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
S7S_09430	COG1070	Carbohydrate kinase
S7S_09435	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
S7S_09440	COG0277	FAD linked oxidase domain protein
S7S_09440	COG0277	FAD linked oxidase domain protein
S7S_09455	COG2885	chlorophyll binding
S7S_09485	COG1192	Involved in chromosome partitioning
S7S_09500	COG0069	glutamate synthase activity
S7S_09505	COG1196	nuclear chromosome segregation
S7S_09505	COG0741	lytic transglycosylase activity
S7S_09505	COG0739	heme binding
S7S_09520	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
S7S_09525	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
S7S_09550	COG2079	MmgE PrpD family protein
S7S_09555	COG2828	Protein conserved in bacteria
S7S_09565	COG0372	Belongs to the citrate synthase family
S7S_09570	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
S7S_09575	COG1802	Transcriptional regulator
S7S_09655	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
S7S_09660	COG0235	Class ii aldolase
S7S_09665	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
S7S_09675	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
S7S_09680	COG2813	Specifically methylates the guanine in position
S7S_09705	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
S7S_09715	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
S7S_09720	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
S7S_09725	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
S7S_09740	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
S7S_09745	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
S7S_09755	COG0316	Belongs to the HesB IscA family
S7S_09755	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
S7S_09760	COG0534	Mate efflux family protein
S7S_09770	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
S7S_09780	COG0598	Magnesium transport protein CorA
S7S_09785	COG0604	alcohol dehydrogenase
S7S_09790	COG0616	signal peptide processing
S7S_09810	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
S7S_09815	COG0328	RNA-DNA hybrid ribonuclease activity
S7S_09830	COG0741	lytic transglycosylase activity
S7S_09830	COG1388	LysM domain
S7S_09835	COG4166	transmembrane transport
S7S_09840	COG4166	transmembrane transport
S7S_09845	COG4174	ABC transporter (Permease)
S7S_09850	COG4239	(ABC) transporter, permease
S7S_09855	COG4172	Belongs to the ABC transporter superfamily
S7S_09865	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
S7S_09875	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
S7S_09880	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
S7S_09885	COG0740	serine-type endopeptidase activity
S7S_09890	COG0544	peptidyl-prolyl cis-trans isomerase activity
S7S_09895	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
S7S_09900	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
S7S_09905	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
S7S_09915	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
S7S_09940	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
S7S_09945	COG3012	SEC-C Motif Domain Protein
S7S_09960	COG0812	UDP-N-acetylmuramate dehydrogenase activity
S7S_09965	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
S7S_09970	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
S7S_09975	COG1663	tetraacyldisaccharide 4'-kinase activity
S7S_09980	COG1132	(ABC) transporter
S7S_09985	COG0848	biopolymer transport protein
S7S_09990	COG0811	peptide transport
S7S_09995	COG2333	competence protein COMEC
S7S_09995	COG0658	competence protein
S7S_10010	COG1136	(ABC) transporter
S7S_10015	COG4591	ABC-type transport system involved in lipoprotein release permease component
S7S_10025	COG2957	Belongs to the agmatine deiminase family
S7S_10030	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
S7S_10045	COG0583	DNA-binding transcription factor activity
S7S_10050	COG0584	glycerophosphoryl diester phosphodiesterase
S7S_10065	COG1477	protein flavinylation
S7S_10075	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
S7S_10095	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
S7S_10105	COG1573	uracil-dna glycosylase
S7S_10110	COG1946	Acyl-CoA thioesterase
S7S_10115	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
S7S_10125	COG2081	HI0933 family
S7S_10145	COG0668	transmembrane transport
S7S_10150	COG1472	Belongs to the glycosyl hydrolase 3 family
S7S_10155	COG1376	ErfK ybiS ycfS ynhG family protein
S7S_10160	COG1309	transcriptional regulator
S7S_10180	COG0589	response to stress
S7S_10190	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
S7S_10200	COG0084	hydrolase, TatD family'
S7S_10210	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
S7S_10210	COG0116	Belongs to the methyltransferase superfamily
S7S_10215	COG3130	regulation of translation
S7S_10230	COG4447	cellulose binding
S7S_10245	COG0308	aminopeptidase N
S7S_10255	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
S7S_10260	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
S7S_10275	COG1309	transcriptional regulator
S7S_10290	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
S7S_10295	COG1960	acyl-CoA dehydrogenase activity
S7S_10300	COG1024	Enoyl-CoA hydratase
S7S_10310	COG0318	PFAM AMP-dependent synthetase and ligase
S7S_10345	COG0604	alcohol dehydrogenase
S7S_10350	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
S7S_10355	COG4106	trans-aconitate 2-methyltransferase activity
S7S_10365	COG0776	regulation of translation
S7S_10375	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
S7S_10380	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
S7S_10385	COG0291	Belongs to the bacterial ribosomal protein bL35 family
S7S_10390	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
S7S_10415	COG2895	sulfate adenylyltransferase (ATP) activity
S7S_10420	COG0175	sulfate reduction
S7S_10430	COG0166	Belongs to the GPI family
S7S_10440	COG1210	Utp--glucose-1-phosphate uridylyltransferase
S7S_10445	COG4771	TonB-dependent receptor
S7S_10475	COG0529	Catalyzes the synthesis of activated sulfate
S7S_10480	COG3273	potassium ion transport
S7S_10480	COG0471	metal ion transport
S7S_10510	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
S7S_10535	COG1086	Polysaccharide biosynthesis protein
S7S_10550	COG0110	maltose O-acetyltransferase activity
S7S_10570	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
S7S_10575	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
S7S_10585	COG1078	dGTPase activity
S7S_10605	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
S7S_10640	COG0250	Participates in transcription elongation, termination and antitermination
S7S_10645	COG0489	protein tyrosine kinase activity
S7S_10645	COG3206	protein involved in exopolysaccharide biosynthesis
S7S_10690	COG0284	orotidine-5'-phosphate decarboxylase activity
S7S_10695	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
S7S_10705	COG0776	regulation of translation
S7S_10715	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
S7S_10720	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
S7S_10735	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
S7S_10745	COG0402	S-adenosylhomocysteine deaminase activity
S7S_10750	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
S7S_10760	COG1028	Short-chain dehydrogenase reductase Sdr
S7S_10775	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
S7S_10800	COG4106	trans-aconitate 2-methyltransferase activity
S7S_10815	COG2983	Belongs to the UPF0260 family
S7S_10820	COG3100	YcgL domain-containing protein
S7S_10835	COG0588	phosphoglycerate mutase activity
S7S_10880	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
S7S_10885	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
S7S_10910	COG2814	Major facilitator Superfamily
S7S_10920	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
S7S_10930	COG0788	formyltetrahydrofolate deformylase activity
S7S_10940	COG1028	Short-chain dehydrogenase reductase Sdr
S7S_10945	COG0302	gtp cyclohydrolase
S7S_10960	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
S7S_10970	COG0659	secondary active sulfate transmembrane transporter activity
S7S_10990	COG1741	Belongs to the pirin family
S7S_10995	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
S7S_10995	COG0475	glutathione-regulated potassium exporter activity
S7S_11005	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
S7S_11070	COG1024	Enoyl-CoA hydratase
S7S_11070	COG1250	3-hydroxyacyl-CoA dehydrogenase
S7S_11075	COG0183	Belongs to the thiolase family
S7S_11085	COG2814	Major facilitator Superfamily
S7S_11100	COG1305	Transglutaminase-like
S7S_11110	COG2308	Evidence 4 Homologs of previously reported genes of
S7S_11155	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
S7S_11165	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
S7S_11170	COG0527	aspartate kinase activity
S7S_11175	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
S7S_11180	COG2137	regulation of response to DNA damage stimulus
S7S_11185	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
S7S_11190	COG1546	Belongs to the CinA family
S7S_11200	COG0519	Catalyzes the synthesis of GMP from XMP
S7S_11200	COG0518	GMP synthase (glutamine-hydrolyzing) activity
S7S_11205	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
S7S_11210	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
S7S_11215	COG1309	transcriptional regulator
S7S_11225	COG0300	oxidoreductase activity
S7S_11240	COG1017	nitric oxide dioxygenase activity
S7S_11240	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
S7S_11255	COG0633	Ferredoxin
S7S_11265	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
S7S_11280	COG3706	GGDEF domain
S7S_11325	COG1960	acyl-CoA dehydrogenase activity
S7S_11330	COG1960	acyl-CoA dehydrogenase activity
S7S_11335	COG0318	PFAM AMP-dependent synthetase and ligase
S7S_11365	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
S7S_11380	COG2003	Belongs to the UPF0758 family
S7S_11485	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
S7S_11490	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
S7S_11525	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
S7S_11540	COG2840	Smr protein MutS2
S7S_11545	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
S7S_11560	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
S7S_11570	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
S7S_11575	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
S7S_11590	COG0717	Belongs to the dCTP deaminase family
S7S_11595	COG0489	protein tyrosine kinase activity
S7S_11640	COG3713	MltA-interacting MipA family protein
S7S_11660	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
S7S_11665	COG2813	Specifically methylates the guanine in position
S7S_11670	COG0741	lytic transglycosylase activity
S7S_11680	COG0564	pseudouridine synthase activity
S7S_11690	COG4681	YaeQ
S7S_11705	COG0154	amidase activity
S7S_11720	COG0625	glutathione transferase activity
S7S_11735	COG3540	Alkaline phosphatase
S7S_11740	COG5002	protein histidine kinase activity
S7S_11740	COG2205	protein histidine kinase activity
S7S_11740	COG0784	Response regulator, receiver
S7S_11745	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
S7S_11745	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
S7S_11755	COG0450	alkyl hydroperoxide reductase
S7S_11765	COG0693	protein deglycase activity
S7S_11770	COG2925	Exonuclease
S7S_11790	COG0418	dihydroorotase activity
S7S_11795	COG5265	(ABC) transporter
S7S_11800	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
S7S_11810	COG1262	PFAM Formylglycine-generating sulfatase enzyme
S7S_11815	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
S7S_11860	COG4657	Part of a membrane complex involved in electron transport
S7S_11865	COG2878	Part of a membrane complex involved in electron transport
S7S_11870	COG4656	Part of a membrane complex involved in electron transport
S7S_11875	COG4658	electron transport chain
S7S_11880	COG4659	FMN binding
S7S_11885	COG4660	Part of a membrane complex involved in electron transport
S7S_11905	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
S7S_11920	COG0189	ligase activity
S7S_11925	COG0189	ligase activity
S7S_11925	COG4067	protein conserved in archaea
S7S_11935	COG0137	argininosuccinate synthase activity
S7S_11940	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
S7S_11965	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
S7S_11970	COG0585	pseudouridine synthase activity
S7S_11975	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
S7S_11985	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
S7S_11990	COG0148	phosphopyruvate hydratase activity
S7S_11995	COG2877	3-deoxy-8-phosphooctulonate synthase activity
S7S_12000	COG0504	CTP synthase activity
S7S_12005	COG0037	tRNA processing
S7S_12010	COG0825	malonyl-CoA metabolic process
S7S_12015	COG4771	TonB-dependent receptor
S7S_12030	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
S7S_12035	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
S7S_12040	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
S7S_12045	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
S7S_12050	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
S7S_12060	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
S7S_12070	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
S7S_12075	COG0575	Belongs to the CDS family
S7S_12085	COG0233	cytoplasmic translational termination
S7S_12090	COG0528	UMP kinase activity
S7S_12095	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
S7S_12105	COG0024	Methionine aminopeptidase
S7S_12120	COG1393	Belongs to the ArsC family
S7S_12125	COG2171	N-acyltransferase activity
S7S_12130	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
S7S_12140	COG1012	belongs to the aldehyde dehydrogenase family
S7S_12145	COG0154	amidase activity
S7S_12160	COG3122	Protein conserved in bacteria
S7S_12165	COG2837	iron assimilation
S7S_12200	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
S7S_12215	COG1309	transcriptional regulator
S7S_12225	COG2937	Belongs to the GPAT DAPAT family
S7S_12235	COG0742	ribosomal rna small subunit methyltransferase
S7S_12240	COG1968	undecaprenyl-diphosphatase activity
S7S_12250	COG1214	PFAM Peptidase M22, glycoprotease
S7S_12255	COG1199	ATP-dependent helicase activity
S7S_12260	COG0746	molybdenum cofactor guanylyltransferase activity
S7S_12270	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
S7S_12275	COG2894	cell division
S7S_12280	COG0850	regulation of cytokinetic process
S7S_12285	COG0563	adenylate kinase activity
S7S_12295	COG4235	cytochrome complex assembly
S7S_12295	COG3088	subunit of a heme lyase
S7S_12300	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
S7S_12305	COG1138	Cytochrome C-type biogenesis protein
S7S_12310	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
S7S_12330	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
S7S_12330	COG2885	chlorophyll binding
S7S_12345	COG3956	TIGRFAM MazG family protein
S7S_12350	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
S7S_12355	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
S7S_12365	COG5002	protein histidine kinase activity
S7S_12365	COG2205	protein histidine kinase activity
S7S_12365	COG0784	Response regulator, receiver
S7S_12370	COG0736	holo-[acyl-carrier-protein] synthase activity
S7S_12375	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
S7S_12390	COG1381	Involved in DNA repair and RecF pathway recombination
S7S_12395	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
S7S_12400	COG0571	ribonuclease III activity
S7S_12415	COG0481	GTPase activity
S7S_12420	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
S7S_12465	COG0204	Acyl-transferase
S7S_12475	COG2133	pyrroloquinoline quinone binding
S7S_12490	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
S7S_12500	COG1960	acyl-CoA dehydrogenase activity
S7S_12515	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
S7S_12525	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
S7S_12540	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
S7S_12545	COG1024	Enoyl-CoA hydratase
S7S_12545	COG1250	3-hydroxyacyl-CoA dehydrogenase
S7S_12550	COG0183	Belongs to the thiolase family
S7S_12555	COG3550	peptidyl-serine autophosphorylation
S7S_12560	COG1396	sequence-specific DNA binding
S7S_12575	COG0513	Belongs to the DEAD box helicase family
S7S_12590	COG0477	Major facilitator Superfamily
S7S_12605	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
S7S_12635	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
S7S_12685	COG3422	double-strand break repair
S7S_12705	COG0545	Peptidyl-prolyl cis-trans isomerase
S7S_12710	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
S7S_12720	COG2801	Transposase and inactivated derivatives
S7S_12735	COG2433	Pfam Transposase IS66
S7S_12740	COG2963	transposase activity
S7S_12760	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
S7S_12770	COG1901	pseudouridine methyltransferase
S7S_12820	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
S7S_12865	COG2226	methyltransferase
S7S_12900	COG0393	Putative heavy-metal-binding
S7S_12910	COG0450	alkyl hydroperoxide reductase
S7S_12935	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
S7S_12945	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
S7S_12945	COG0778	Nitroreductase
S7S_13000	COG0642	Histidine kinase
S7S_13005	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
S7S_13050	COG1960	acyl-CoA dehydrogenase activity
S7S_13055	COG1960	acyl-CoA dehydrogenase activity
S7S_13080	COG0446	pyridine nucleotide-disulphide oxidoreductase
S7S_13080	COG1902	pentaerythritol trinitrate reductase activity
S7S_13090	COG0183	Belongs to the thiolase family
S7S_13095	COG1028	Short-chain dehydrogenase reductase Sdr
S7S_13115	COG1309	transcriptional regulator
S7S_13130	COG1943	Transposase
S7S_13145	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
S7S_13150	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
S7S_13165	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
S7S_13170	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
S7S_13175	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
S7S_13180	COG0193	aminoacyl-tRNA hydrolase activity
S7S_13195	COG0582	viral genome integration into host DNA
S7S_13205	COG1205	dead DEAH box helicase
S7S_13205	COG1111	helicase
S7S_13210	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
S7S_13275	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
S7S_13280	COG1942	4-Oxalocrotonate Tautomerase
S7S_13290	COG4638	Rieske (2fe-2S)
S7S_13320	COG1028	Short-chain dehydrogenase reductase Sdr
S7S_13340	COG0494	nUDIX hydrolase
S7S_13345	COG1414	Transcriptional regulator
S7S_13375	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
S7S_13380	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
S7S_13385	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
S7S_13390	COG1845	cytochrome c oxidase, subunit III
S7S_13410	COG1612	heme a metabolic process
S7S_13415	COG0109	protoheme IX farnesyltransferase activity
S7S_13420	COG1704	LemA family
S7S_13425	COG0501	Belongs to the peptidase M48B family
S7S_13435	COG0644	oxidoreductase
S7S_13440	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
S7S_13455	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
S7S_13500	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
S7S_13505	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
S7S_13545	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
S7S_13550	COG4150	thiosulfate binding
S7S_13560	COG4208	sulfate ABC transporter
S7S_13565	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
S7S_13570	COG1702	phosphate starvation-inducible protein PhoH
S7S_13575	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
S7S_13580	COG4535	Mg2 and Co2 transporter CorC
S7S_13595	COG0815	Transfers the fatty acyl group on membrane lipoproteins
S7S_13610	COG0495	leucyl-tRNA aminoacylation
S7S_13620	COG1466	dna polymerase III delta subunit
S7S_13635	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
S7S_13640	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
S7S_13650	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
S7S_13655	COG0768	penicillin binding
S7S_13660	COG0772	Belongs to the SEDS family
S7S_13665	COG2951	lytic endotransglycosylase activity
S7S_13675	COG1686	Belongs to the peptidase S11 family
S7S_13690	COG0321	lipoyl(octanoyl) transferase activity
S7S_13695	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
S7S_13730	COG3384	dioxygenase
S7S_13745	COG0811	peptide transport
S7S_13760	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
S7S_13770	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
S7S_13775	COG4208	sulfate ABC transporter
S7S_13785	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
S7S_13820	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
S7S_13840	COG0410	ABC transporter
S7S_13845	COG0411	ABC transporter
S7S_13850	COG1172	Belongs to the binding-protein-dependent transport system permease family
S7S_13860	COG0683	leucine binding
S7S_13865	COG0784	Response regulator, receiver
S7S_13865	COG2205	protein histidine kinase activity
S7S_13865	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
S7S_13865	COG2198	Histidine kinase
S7S_13870	COG0745	RESPONSE REGULATOR receiver
S7S_13870	COG3706	GGDEF domain
S7S_13875	COG0205	6-phosphofructokinase activity
S7S_13885	COG0513	Belongs to the DEAD box helicase family
S7S_13890	COG3273	potassium ion transport
S7S_13890	COG0471	metal ion transport
S7S_13895	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
S7S_13905	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
S7S_13910	COG3657	addiction module killer protein
S7S_13925	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
S7S_13930	COG0511	ligase activity, forming carbon-carbon bonds
S7S_13940	COG2264	protein methyltransferase activity
S7S_13960	COG0138	bifunctional purine biosynthesis protein purh
S7S_13965	COG0151	Belongs to the GarS family
S7S_13975	COG0784	Response regulator, receiver
S7S_13975	COG5002	protein histidine kinase activity
S7S_13975	COG2205	protein histidine kinase activity
S7S_13985	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
S7S_13990	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
S7S_14005	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
S7S_14015	COG1765	OsmC-like protein
S7S_14040	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
S7S_14045	COG1250	3-hydroxyacyl-CoA dehydrogenase
S7S_14050	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
S7S_14065	COG0583	DNA-binding transcription factor activity
S7S_14075	COG2353	YceI-like domain
S7S_14080	COG2205	protein histidine kinase activity
S7S_14085	COG0745	RESPONSE REGULATOR receiver
S7S_14120	COG3795	YCII-related domain
S7S_14125	COG4941	Belongs to the sigma-70 factor family
S7S_14150	COG0134	indole-3-glycerol-phosphate synthase activity
S7S_14155	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
S7S_14160	COG0512	Glutamine amidotransferase of anthranilate synthase
S7S_14180	COG5002	protein histidine kinase activity
S7S_14185	COG0745	RESPONSE REGULATOR receiver
S7S_14225	COG2372	response to copper ion
S7S_14235	COG0583	DNA-binding transcription factor activity
S7S_14245	COG0789	Transcriptional regulator
S7S_14255	COG2226	methyltransferase
S7S_14265	COG1192	Involved in chromosome partitioning
S7S_14305	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
S7S_14410	COG1074	ATP-dependent DNA helicase activity
S7S_14465	COG2003	Belongs to the UPF0758 family
S7S_14525	COG0582	viral genome integration into host DNA
S7S_14530	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
S7S_14535	COG3047	cAMP biosynthetic process
S7S_14560	COG1191	sigma factor activity
S7S_14570	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
S7S_14585	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
S7S_14590	COG0745	RESPONSE REGULATOR receiver
S7S_14595	COG0840	transmembrane signaling receptor activity
S7S_14600	COG2201	protein-glutamate methylesterase activity
S7S_14605	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
S7S_14610	COG0840	transmembrane signaling receptor activity
S7S_14615	COG0835	chemotaxis
S7S_14620	COG0643	Histidine kinase
S7S_14620	COG2198	Histidine kinase
S7S_14625	COG1360	Flagellar Motor Protein
S7S_14645	COG2257	FlhB HrpN YscU SpaS Family
S7S_14665	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
S7S_14685	COG1334	flagellar protein FlaG
S7S_14695	COG1766	The M ring may be actively involved in energy transduction
S7S_14700	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
S7S_14735	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
S7S_14770	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
S7S_14775	COG1256	bacterial-type flagellum assembly
S7S_14780	COG1705	Flagellar rod assembly protein muramidase FlgJ
S7S_14780	COG3951	Flagellar rod assembly protein muramidase FlgJ
S7S_14785	COG1706	bacterial-type flagellum-dependent cell motility
S7S_14795	COG4786	Flagellar basal body rod
S7S_14800	COG4787	bacterial-type flagellum-dependent cell motility
S7S_14805	COG1749	Flagellar hook protein flgE
S7S_14810	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
S7S_14815	COG1558	bacterial-type flagellum-dependent cell motility
S7S_14820	COG1815	bacterial-type flagellum-dependent cell motility
S7S_14850	COG1733	regulation of RNA biosynthetic process
S7S_14865	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
S7S_14895	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
S7S_14900	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
S7S_14910	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
S7S_14915	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
S7S_14920	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
S7S_14925	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
S7S_14930	COG2967	ApaG domain
S7S_14935	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
S7S_14940	COG2766	serine protein kinase
S7S_14945	COG2718	Belongs to the UPF0229 family
S7S_14950	COG2719	SpoVR family
S7S_14970	COG0617	tRNA 3'-terminal CCA addition
S7S_15005	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
S7S_15010	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
S7S_15015	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
S7S_15020	COG0828	Belongs to the bacterial ribosomal protein bS21 family
S7S_15035	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
S7S_15045	COG2205	protein histidine kinase activity
S7S_15045	COG0784	Response regulator, receiver
S7S_15080	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
S7S_15080	COG3453	Protein conserved in bacteria
S7S_15095	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
S7S_15100	COG4221	oxidoreductase activity
S7S_15110	COG3094	Invasion gene expression up-regulator, SirB
S7S_15125	COG0583	DNA-binding transcription factor activity
S7S_15130	COG2814	Major facilitator Superfamily
S7S_15135	COG0656	L-ascorbic acid biosynthetic process
S7S_15145	COG1116	anion transmembrane transporter activity
S7S_15155	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
S7S_15175	COG2356	endonuclease I
S7S_15180	COG1960	acyl-CoA dehydrogenase activity
S7S_15185	COG1960	acyl-CoA dehydrogenase activity
S7S_15190	COG2835	tetraacyldisaccharide 4'-kinase activity
S7S_15195	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
S7S_15220	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
S7S_15290	COG0300	oxidoreductase activity
S7S_15295	COG0537	adenosine 5'-monophosphoramidase activity
S7S_15315	COG2205	protein histidine kinase activity
S7S_15315	COG0784	Response regulator, receiver
S7S_15330	COG2203	Gaf domain
S7S_15330	COG4251	negative regulation of phosphorylation
S7S_15330	COG5001	Diguanylate cyclase
S7S_15330	COG3706	GGDEF domain
S7S_15340	COG0739	heme binding
S7S_15345	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
S7S_15350	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
S7S_15355	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
S7S_15360	COG0215	cysteine-tRNA ligase activity
S7S_15365	COG1289	transmembrane transporter activity
S7S_15370	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
S7S_15400	COG1469	GTP cyclohydrolase I activity
S7S_15415	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
S7S_15420	COG1917	Cupin 2, conserved barrel domain protein
S7S_15450	COG0477	Major facilitator Superfamily
S7S_15460	COG0784	Response regulator, receiver
S7S_15460	COG2205	protein histidine kinase activity
S7S_15460	COG2198	Histidine kinase
S7S_15470	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
S7S_15480	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
S7S_15505	COG0142	geranyltranstransferase activity
S7S_15510	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
S7S_15535	COG0745	RESPONSE REGULATOR receiver
S7S_15535	COG3706	GGDEF domain
S7S_15540	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
S7S_15550	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
S7S_15555	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
S7S_15565	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
S7S_15570	COG3132	Protein of unknown function, DUF480
S7S_15585	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
S7S_15585	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
S7S_15590	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
S7S_15595	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
S7S_15605	COG0488	(ABC) transporter
S7S_15625	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
S7S_15630	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
S7S_15635	COG0305	Participates in initiation and elongation during chromosome replication
S7S_15640	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
S7S_15665	COG0359	binds to the 23S rRNA
S7S_15670	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
S7S_15680	COG0360	Binds together with S18 to 16S ribosomal RNA
S7S_15695	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
S7S_15700	COG0557	exoribonuclease II activity
S7S_15720	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
S7S_15725	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
S7S_15735	COG0330	HflC and HflK could
S7S_15740	COG0330	HflC and HflK could
S7S_15745	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
S7S_15750	COG1923	regulation of RNA biosynthetic process
S7S_15765	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
S7S_15770	COG0860	N-Acetylmuramoyl-L-alanine amidase
S7S_15775	COG0802	atpase or kinase
S7S_15780	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
S7S_15780	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
S7S_15810	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
S7S_15820	COG1162	GTPase activity
S7S_15830	COG0688	phosphatidylethanolamine metabolic process
S7S_15845	COG0560	Phosphoserine phosphatase
S7S_15845	COG3830	Belongs to the UPF0237 family
S7S_15860	COG1509	lysine 2,3-aminomutase activity
S7S_15865	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
S7S_15890	COG1489	DNA binding
S7S_15905	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
S7S_15920	COG3852	Histidine kinase
S7S_15925	COG2204	response regulator
S7S_15940	COG1428	Deoxynucleoside kinase
S7S_15945	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
S7S_15950	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
S7S_15955	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
S7S_15960	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
S7S_15970	COG2963	transposase activity
S7S_15975	COG2801	Transposase and inactivated derivatives
S7S_15980	COG2197	response regulator
S7S_15985	COG2814	Major facilitator Superfamily
S7S_16025	COG2814	Major facilitator Superfamily
S7S_16035	COG0024	Methionine aminopeptidase
S7S_16040	COG0586	Pfam SNARE associated Golgi protein
S7S_16070	COG0583	DNA-binding transcription factor activity
S7S_16080	COG2979	Protein of unknown function (DUF533)
S7S_16085	COG1960	acyl-CoA dehydrogenase activity
S7S_16090	COG1280	lysine exporter protein (LysE YggA)
S7S_16125	COG3909	cytochrome
S7S_16170	COG0488	(ABC) transporter
S7S_16175	COG4993	Dehydrogenase
S7S_16190	COG0840	transmembrane signaling receptor activity
S7S_16200	COG0436	Aminotransferase
S7S_16205	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
S7S_16210	COG0242	peptide deformylase activity
S7S_16215	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
S7S_16220	COG1278	Cold shock
S7S_16225	COG1595	DNA-templated transcription, initiation
S7S_16275	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
S7S_16290	COG1960	acyl-CoA dehydrogenase activity
S7S_16295	COG1028	Short-chain dehydrogenase reductase Sdr
S7S_16310	COG1652	LysM domain
S7S_16310	COG2823	Periplasmic or secreted lipoprotein
S7S_16320	COG1944	ATP diphosphatase activity
S7S_16340	COG0747	negative chemotaxis
S7S_16350	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
S7S_16365	COG0596	Alpha beta hydrolase
S7S_16370	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
S7S_16405	COG0210	DNA helicase
S7S_16470	COG1185	polyribonucleotide nucleotidyltransferase activity
S7S_16475	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
S7S_16480	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
S7S_16485	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
S7S_16490	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
S7S_16495	COG0195	Participates in both transcription termination and antitermination
S7S_16500	COG0779	Required for maturation of 30S ribosomal subunits
S7S_16510	COG0149	triose-phosphate isomerase activity
S7S_16515	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
S7S_16520	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
S7S_16525	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
S7S_16530	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
S7S_16535	COG1534	Rna-binding protein
S7S_16540	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
S7S_16545	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
S7S_16550	COG0505	Belongs to the CarA family
S7S_16555	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
S7S_16560	COG1320	monovalent cation:proton antiporter activity
S7S_16565	COG2212	antiporter activity
S7S_16575	COG0651	ATP synthesis coupled electron transport
S7S_16580	COG1006	Multisubunit Na H antiporter MnhC subunit
S7S_16585	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
S7S_16585	COG2111	Na H antiporter
S7S_16590	COG0484	heat shock protein binding
S7S_16595	COG0443	Heat shock 70 kDa protein
S7S_16600	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
S7S_16605	COG1420	regulation of RNA biosynthetic process
S7S_16610	COG0497	DNA recombination
S7S_16625	COG2914	Belongs to the UPF0125 (RnfH) family
S7S_16630	COG0733	neurotransmitter:sodium symporter activity
S7S_16635	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
S7S_16660	COG2963	transposase activity
S7S_16665	COG2801	Transposase and inactivated derivatives
S7S_16685	COG5499	transcription regulator containing HTH domain
S7S_16695	COG0861	Integral membrane protein TerC family
S7S_16715	COG1136	(ABC) transporter
S7S_16725	COG2267	carboxylic ester hydrolase activity
S7S_16730	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
S7S_16735	COG3015	lipoprotein NlpE involved in copper resistance
S7S_16740	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
S7S_16750	COG1492	cobalamin metabolic process
S7S_16755	COG1253	flavin adenine dinucleotide binding
S7S_16765	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
S7S_16770	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
S7S_16775	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
S7S_16780	COG4206	TonB-dependent receptor
S7S_16800	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
S7S_16810	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
S7S_16850	COG0303	'Molybdopterin
S7S_16855	COG0521	Mo-molybdopterin cofactor biosynthetic process
S7S_16865	COG0521	Mo-molybdopterin cofactor biosynthetic process
S7S_16870	COG3177	Filamentation induced by cAMP protein fic
S7S_16875	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
S7S_16900	COG0432	Pfam Uncharacterised protein family UPF0047
S7S_16905	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
S7S_16915	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
S7S_16920	COG1166	arginine decarboxylase activity
S7S_16925	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
S7S_16935	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
S7S_16940	COG2072	flavoprotein involved in K transport
S7S_16950	COG0456	acetyltransferase
S7S_16970	COG0583	DNA-binding transcription factor activity
S7S_16975	COG1960	acyl-CoA dehydrogenase activity
S7S_16990	COG2267	carboxylic ester hydrolase activity
S7S_17030	COG2161	toxin-antitoxin pair type II binding
S7S_17060	COG0004	ammonium transporteR
S7S_17065	COG0347	Belongs to the P(II) protein family
S7S_17070	COG2960	long-chain fatty acid transporting porin activity
S7S_17095	COG1028	Short-chain dehydrogenase reductase Sdr
S7S_17100	COG0210	DNA helicase
S7S_17120	COG5002	protein histidine kinase activity
S7S_17140	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
S7S_17145	COG0469	pyruvate kinase activity
S7S_17160	COG4771	TonB-dependent receptor
S7S_17175	COG2133	pyrroloquinoline quinone binding
S7S_17200	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
S7S_17210	COG0842	Transport permease protein
S7S_17215	COG1131	(ABC) transporter
S7S_17225	COG1309	transcriptional regulator
S7S_17230	COG1028	Short-chain dehydrogenase reductase Sdr
S7S_17260	COG3093	addiction module antidote protein HigA
S7S_17280	COG1028	Short-chain dehydrogenase reductase Sdr
S7S_17285	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
S7S_17290	COG0385	Bile acid
S7S_17295	COG2072	flavoprotein involved in K transport
S7S_17320	COG2378	regulation of single-species biofilm formation
S7S_17330	COG1024	Enoyl-CoA hydratase
S7S_17335	COG0517	IMP dehydrogenase activity
S7S_17335	COG1125	glycine betaine transport
S7S_17340	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
S7S_17340	COG0678	peroxiredoxin activity
S7S_17345	COG0783	Belongs to the Dps family
S7S_17350	COG0753	catalase activity
S7S_17355	COG1970	mechanosensitive ion channel activity
S7S_17360	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
S7S_17385	COG1272	protein, Hemolysin III
S7S_17390	COG0655	NAD(P)H dehydrogenase (quinone) activity
S7S_17415	COG1028	Short-chain dehydrogenase reductase Sdr
S7S_17430	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
S7S_17430	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
S7S_17440	COG0640	Transcriptional regulator
S7S_17465	COG1733	regulation of RNA biosynthetic process
S7S_17470	COG0386	Belongs to the glutathione peroxidase family
S7S_17525	COG1346	cytolysis
S7S_17530	COG1380	Effector of murein hydrolase LrgA
S7S_17535	COG0583	DNA-binding transcription factor activity
S7S_17550	COG3128	pkhd-type hydroxylase
S7S_17560	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
S7S_17585	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
S7S_17590	COG1074	ATP-dependent DNA helicase activity
S7S_17595	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
S7S_17605	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
S7S_17620	COG0218	Necessary for normal cell division and for the maintenance of normal septation
S7S_17640	COG1309	transcriptional regulator
S7S_17665	COG1121	(ABC) transporter
S7S_17670	COG1108	ABC-type Mn2 Zn2 transport systems permease components
S7S_17690	COG1309	transcriptional regulator
S7S_17715	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
S7S_17720	COG1773	rubredoxin
S7S_17725	COG3161	chorismate lyase activity
S7S_17730	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
S7S_17760	COG2119	membrane
S7S_17765	COG0431	NADPH-dependent FMN reductase
S7S_17770	COG0798	PFAM Bile acid sodium symporter
S7S_17775	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
S7S_17780	COG0640	Transcriptional regulator
S7S_17790	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
S7S_17800	COG0573	inorganic phosphate transmembrane transporter activity
S7S_17810	COG1607	acyl-coa hydrolase
S7S_17820	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
S7S_17825	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
S7S_17825	COG2813	Specifically methylates the guanine in position
S7S_17830	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
S7S_17840	COG0635	Involved in the biosynthesis of porphyrin-containing compound
S7S_17850	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
S7S_17855	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
S7S_17865	COG1385	rRNA (uridine-N3-)-methyltransferase activity
S7S_17870	COG2373	Large extracellular alpha-helical protein
S7S_17895	COG3038	cytochrome b561
S7S_17915	COG2201	protein-glutamate methylesterase activity
S7S_17920	COG2198	Histidine kinase
S7S_17920	COG0643	Histidine kinase
S7S_17930	COG0840	transmembrane signaling receptor activity
S7S_17950	COG0189	ligase activity
S7S_17960	COG1678	Uncharacterized ACR, COG1678
S7S_17965	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
S7S_17975	COG0540	Belongs to the ATCase OTCase family
S7S_17985	COG0659	secondary active sulfate transmembrane transporter activity
S7S_17990	COG0589	response to stress
S7S_18030	COG0435	Glutathione S-transferase
S7S_18070	COG1872	DUF167
S7S_18075	COG0210	DNA helicase
S7S_18085	COG3093	addiction module antidote protein HigA
S7S_18095	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
S7S_18100	COG0583	DNA-binding transcription factor activity
S7S_18105	COG2239	Acts as a magnesium transporter
S7S_18110	COG1538	Outer membrane efflux protein
S7S_18120	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
S7S_18135	COG1793	dna ligase
S7S_18190	COG1595	DNA-templated transcription, initiation
S7S_18225	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
S7S_18230	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
S7S_18235	COG0355	proton-transporting ATP synthase activity, rotational mechanism
S7S_18240	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
S7S_18245	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
S7S_18250	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
S7S_18255	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
S7S_18260	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
S7S_18270	COG0356	it plays a direct role in the translocation of protons across the membrane
S7S_18280	COG0477	Major facilitator Superfamily
S7S_18285	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
S7S_18290	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
S7S_18295	COG1845	cytochrome c oxidase, subunit III
S7S_18310	COG2205	protein histidine kinase activity
S7S_18315	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
S7S_18345	COG1475	DNA binding
S7S_18350	COG1192	Involved in chromosome partitioning
S7S_18355	COG0357	Ribosomal RNA small subunit methyltransferase G
S7S_18360	COG0445	tRNA wobble uridine modification
S7S_18365	COG3263	regulation of cellular component size
S7S_18370	COG1960	acyl-CoA dehydrogenase activity
S7S_18380	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
S7S_18390	COG0300	oxidoreductase activity
S7S_18395	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
S7S_18400	COG0330	HflC and HflK could
S7S_18410	COG1278	Cold shock
S7S_18415	COG2827	Endonuclease containing a URI domain
S7S_18455	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
S7S_18465	COG2204	response regulator
S7S_18475	COG0318	PFAM AMP-dependent synthetase and ligase
S7S_18490	COG4191	Histidine kinase
S7S_18495	COG0784	Response regulator, receiver
S7S_18495	COG2205	protein histidine kinase activity
S7S_18525	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
S7S_18555	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
S7S_18560	COG0706	membrane insertase activity
S7S_18565	COG0594	ribonuclease P activity
S7S_18570	COG0230	Belongs to the bacterial ribosomal protein bL34 family