locus-tag	class	description
HML84_00005	COG4774	siderophore transport
HML84_00065	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HML84_00070	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HML84_00150	COG1960	acyl-CoA dehydrogenase activity
HML84_00155	COG2130	NADP-dependent
HML84_00170	COG4774	siderophore transport
HML84_00175	COG4774	siderophore transport
HML84_00180	COG4774	siderophore transport
HML84_00210	COG0235	Class ii aldolase
HML84_00255	COG1764	response to oxidative stress
HML84_00320	COG3344	reverse transcriptase
HML84_00750	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
HML84_00805	COG0438	transferase activity, transferring glycosyl groups
HML84_00825	COG0438	transferase activity, transferring glycosyl groups
HML84_00870	COG0463	Glycosyl transferase, family 2
HML84_00870	COG1216	Glycosyl transferase, family 2
HML84_00935	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HML84_00945	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HML84_00965	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
HML84_01080	COG0457	Tetratricopeptide repeat
HML84_01085	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
HML84_01125	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
HML84_01225	COG0546	phosphoglycolate phosphatase activity
HML84_01250	COG0077	Prephenate dehydratase
HML84_01250	COG1605	Chorismate mutase
HML84_01265	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HML84_01275	COG0776	regulation of translation
HML84_01335	COG4657	Part of a membrane complex involved in electron transport
HML84_01430	COG0436	Aminotransferase
HML84_01470	COG2205	protein histidine kinase activity
HML84_01510	COG0583	DNA-binding transcription factor activity
HML84_01570	COG1024	Enoyl-CoA hydratase
HML84_01715	COG2853	Lipoprotein
HML84_01730	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HML84_01765	COG5642	Protein of unknown function (DUF2384)
HML84_01790	COG2009	succinate dehydrogenase
HML84_01795	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
HML84_01800	COG1053	succinate dehydrogenase
HML84_01970	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HML84_02005	COG0159	tryptophan synthase activity
HML84_02045	COG0714	Associated with various cellular activities
HML84_02105	COG5001	Diguanylate cyclase
HML84_02105	COG3706	GGDEF domain
HML84_02105	COG2203	Gaf domain
HML84_02105	COG4251	negative regulation of phosphorylation
HML84_02160	COG3228	Belongs to the MtfA family
HML84_02165	COG3228	Belongs to the MtfA family
HML84_02290	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HML84_02320	COG0039	L-malate dehydrogenase activity
HML84_02340	COG2272	Belongs to the type-B carboxylesterase lipase family
HML84_02345	COG0271	Belongs to the BolA IbaG family
HML84_02395	COG0037	tRNA processing
HML84_02410	COG1309	transcriptional regulator
HML84_02445	COG0559	Belongs to the binding-protein-dependent transport system permease family
HML84_02535	COG0315	cyclic pyranopterin monophosphate synthase activity
HML84_02565	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HML84_02585	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
HML84_02595	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
HML84_02600	COG0492	ferredoxin-NADP+ reductase activity
HML84_02610	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
HML84_02645	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
HML84_02700	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HML84_02725	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HML84_02840	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
HML84_02850	COG0235	Class ii aldolase
HML84_02890	COG0560	Phosphoserine phosphatase
HML84_02900	COG1802	Transcriptional regulator
HML84_02905	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
HML84_02910	COG0372	Belongs to the citrate synthase family
HML84_02930	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
HML84_02945	COG1196	nuclear chromosome segregation
HML84_02945	COG0741	lytic transglycosylase activity
HML84_02945	COG0739	heme binding
HML84_02995	COG2885	chlorophyll binding
HML84_03025	COG2814	Major facilitator Superfamily
HML84_03045	COG4181	ATPase activity
HML84_03075	COG0204	Acyl-transferase
HML84_03105	COG2917	probably involved in intracellular septation
HML84_03130	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HML84_03150	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HML84_03160	COG0697	spore germination
HML84_03165	COG0330	HflC and HflK could
HML84_03205	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HML84_03280	COG3473	Maleate cis-trans isomerase
HML84_03305	COG1846	Transcriptional regulator
HML84_03325	COG2010	Cytochrome c
HML84_03375	COG0589	response to stress
HML84_03395	COG0598	Magnesium transport protein CorA
HML84_03495	COG0501	Belongs to the peptidase M48B family
HML84_03515	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HML84_03560	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HML84_03575	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HML84_03635	COG0740	serine-type endopeptidase activity
HML84_03710	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HML84_03775	COG2010	Cytochrome c
HML84_03775	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HML84_03790	COG2814	Major facilitator Superfamily
HML84_03970	COG0840	transmembrane signaling receptor activity
HML84_03975	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HML84_04000	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HML84_04015	COG2146	nitrite reductase [NAD(P)H] activity
HML84_04150	COG4206	TonB-dependent receptor
HML84_04215	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HML84_04240	COG1399	metal-binding, possibly nucleic acid-binding protein
HML84_04245	COG0424	maF-like protein
HML84_04275	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HML84_04325	COG0848	biopolymer transport protein
HML84_04345	COG0658	competence protein
HML84_04345	COG2333	competence protein COMEC
HML84_04385	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HML84_04390	COG1307	EDD domain protein, DegV family
HML84_04405	COG0788	formyltetrahydrofolate deformylase activity
HML84_04445	COG1301	dicarboxylic acid transport
HML84_04450	COG1301	dicarboxylic acid transport
HML84_04460	COG1301	dicarboxylic acid transport
HML84_04500	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
HML84_04520	COG1687	branched-chain amino acid
HML84_04535	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HML84_04540	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HML84_04545	COG1120	ATPase activity
HML84_04550	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
HML84_04570	COG4558	Periplasmic binding protein
HML84_04645	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HML84_04670	COG2144	transferase activity, transferring acyl groups
HML84_04740	COG0717	Belongs to the dCTP deaminase family
HML84_04745	COG0489	protein tyrosine kinase activity
HML84_04765	COG0450	alkyl hydroperoxide reductase
HML84_04855	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
HML84_04880	COG0741	lytic transglycosylase activity
HML84_04930	COG3210	domain, Protein
HML84_04965	COG2831	hemolysin activation secretion protein
HML84_04985	COG3001	Fructosamine kinase
HML84_05030	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HML84_05040	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
HML84_05065	COG0037	tRNA processing
HML84_05070	COG0037	tRNA processing
HML84_05095	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HML84_05140	COG0233	cytoplasmic translational termination
HML84_05155	COG0052	Belongs to the universal ribosomal protein uS2 family
HML84_05260	COG0746	molybdenum cofactor guanylyltransferase activity
HML84_05300	COG0850	regulation of cytokinetic process
HML84_05310	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
HML84_05375	COG2030	dehydratase
HML84_05405	COG0531	amino acid
HML84_05420	COG1254	Belongs to the acylphosphatase family
HML84_05430	COG1393	Belongs to the ArsC family
HML84_05500	COG3101	peptidyl-lysine hydroxylation
HML84_05570	COG3077	Addiction module antitoxin, RelB DinJ family
HML84_05620	COG0545	Peptidyl-prolyl cis-trans isomerase
HML84_05630	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HML84_05725	COG0583	DNA-binding transcription factor activity
HML84_05780	COG2871	sodium ion transport
HML84_05785	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HML84_05930	COG1739	Uncharacterized protein family UPF0029
HML84_06045	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HML84_06100	COG1741	Belongs to the pirin family
HML84_06230	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HML84_06260	COG1546	Belongs to the CinA family
HML84_06405	COG3311	Transcriptional regulator
HML84_06495	COG0745	RESPONSE REGULATOR receiver
HML84_06510	COG3077	Addiction module antitoxin, RelB DinJ family
HML84_06625	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
HML84_06695	COG1074	ATP-dependent DNA helicase activity
HML84_06700	COG1074	ATP-dependent DNA helicase activity
HML84_06705	COG1074	ATP-dependent DNA helicase activity
HML84_06710	COG1074	ATP-dependent DNA helicase activity
HML84_06715	COG1074	ATP-dependent DNA helicase activity
HML84_06800	COG0776	regulation of translation
HML84_06815	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HML84_06870	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HML84_06895	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HML84_06905	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HML84_06905	COG0425	Belongs to the sulfur carrier protein TusA family
HML84_06925	COG4773	Receptor
HML84_06955	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HML84_06990	COG0789	Transcriptional regulator
HML84_07005	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HML84_07065	COG0632	four-way junction helicase activity
HML84_07070	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
HML84_07075	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
HML84_07080	COG0217	transcriptional regulatory protein
HML84_07085	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HML84_07140	COG2911	Protein conserved in bacteria
HML84_07150	COG2911	Protein conserved in bacteria
HML84_07180	COG1960	acyl-CoA dehydrogenase activity
HML84_07220	COG0513	Belongs to the DEAD box helicase family
HML84_07285	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HML84_07315	COG0745	RESPONSE REGULATOR receiver
HML84_07455	COG3971	2-oxopent-4-enoate hydratase activity
HML84_07470	COG1846	Transcriptional regulator
HML84_07475	COG0861	Integral membrane protein TerC family
HML84_07735	COG1611	Belongs to the LOG family
HML84_07835	COG0583	DNA-binding transcription factor activity
HML84_07935	COG3237	CsbD-like
HML84_07985	COG1749	Flagellar hook protein flgE
HML84_07990	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
HML84_08055	COG0459	protein refolding
HML84_08095	COG0745	RESPONSE REGULATOR receiver
HML84_08175	COG0438	transferase activity, transferring glycosyl groups
HML84_08235	COG0237	dephospho-CoA kinase activity
HML84_08240	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
HML84_08290	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HML84_08325	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HML84_08330	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HML84_08395	COG0625	glutathione transferase activity
HML84_08400	COG2857	Cytochrome c1
HML84_08415	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HML84_08460	COG1802	Transcriptional regulator
HML84_08500	COG2067	long-chain fatty acid transport protein
HML84_08515	COG2945	thiolester hydrolase activity
HML84_08560	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HML84_08580	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HML84_08595	COG1137	ATPase activity
HML84_08615	COG1660	Displays ATPase and GTPase activities
HML84_08625	COG2239	Acts as a magnesium transporter
HML84_08740	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
HML84_08745	COG1792	Involved in formation and maintenance of cell shape
HML84_08755	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HML84_08830	COG0848	biopolymer transport protein
HML84_08870	COG1595	DNA-templated transcription, initiation
HML84_09040	COG1045	serine acetyltransferase
HML84_09115	COG1309	transcriptional regulator
HML84_09195	COG1028	Short-chain dehydrogenase reductase Sdr
HML84_09205	COG0318	PFAM AMP-dependent synthetase and ligase
HML84_09325	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HML84_09375	COG2963	transposase activity
HML84_09400	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HML84_09435	COG0318	PFAM AMP-dependent synthetase and ligase
HML84_09440	COG0318	PFAM AMP-dependent synthetase and ligase
HML84_09560	COG4969	Belongs to the N-Me-Phe pilin family
HML84_09565	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HML84_09595	COG0268	Binds directly to 16S ribosomal RNA
HML84_09615	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HML84_09815	COG0203	ribosomal protein L17
HML84_09820	COG0202	RNA polymerase activity
HML84_09830	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HML84_09835	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HML84_09840	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HML84_09850	COG0200	Binds to the 23S rRNA
HML84_09865	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HML84_09880	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HML84_09890	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HML84_09895	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HML84_09900	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HML84_09905	COG0255	Belongs to the universal ribosomal protein uL29 family
HML84_09925	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HML84_09955	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HML84_09965	COG0049	tRNA binding
HML84_09990	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HML84_09995	COG0081	regulation of translation
HML84_10020	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HML84_10055	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
HML84_10055	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
HML84_10115	COG0316	Belongs to the HesB IscA family
HML84_10265	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
HML84_10280	COG1566	PFAM secretion protein HlyD family protein
HML84_10305	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HML84_10345	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HML84_10360	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
HML84_10420	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HML84_10435	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HML84_10485	COG0154	amidase activity
HML84_10570	COG2807	transmembrane transport
HML84_10575	COG2807	transmembrane transport
HML84_10740	COG1881	PFAM PEBP family protein
HML84_10745	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HML84_10785	COG2154	pterin-4-alpha-carbinolamine dehydratase
HML84_10845	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HML84_10850	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HML84_10890	COG0254	rRNA binding
HML84_10925	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
HML84_10935	COG2226	methyltransferase
HML84_10955	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HML84_10970	COG1073	alpha beta
HML84_11020	COG0174	glutamine synthetase
HML84_11025	COG0425	Belongs to the sulfur carrier protein TusA family
HML84_11040	COG0189	ligase activity
HML84_11080	COG4942	peptidase
HML84_11090	COG2861	carbohydrate metabolic process
HML84_11115	COG1671	Belongs to the UPF0178 family
HML84_11145	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HML84_11155	COG0131	Imidazoleglycerol-phosphate dehydratase
HML84_11190	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HML84_11405	COG0739	heme binding
HML84_11435	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HML84_11445	COG1172	Belongs to the binding-protein-dependent transport system permease family
HML84_11475	COG0583	DNA-binding transcription factor activity
HML84_11520	COG0411	ABC transporter
HML84_11545	COG1733	regulation of RNA biosynthetic process
HML84_11555	COG0024	Methionine aminopeptidase
HML84_11620	COG2207	Transcriptional regulator
HML84_11675	COG3239	Fatty acid desaturase
HML84_11690	COG4774	siderophore transport
HML84_11700	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HML84_11705	COG3012	SEC-C Motif Domain Protein
HML84_11710	COG3012	SEC-C Motif Domain Protein
HML84_11750	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HML84_11775	COG0473	3-isopropylmalate dehydrogenase activity
HML84_11840	COG2072	flavoprotein involved in K transport
HML84_11960	COG4206	TonB-dependent receptor
HML84_12000	COG3344	reverse transcriptase
HML84_12175	COG0730	response to heat
HML84_12295	COG0154	amidase activity
HML84_12300	COG0154	amidase activity
HML84_12320	COG1278	Cold shock
HML84_12375	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HML84_12410	COG1360	Flagellar Motor Protein
HML84_12490	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
HML84_12495	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
HML84_12545	COG2207	Transcriptional regulator
HML84_12590	COG3712	iron ion homeostasis
HML84_12670	COG2963	transposase activity
HML84_12825	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
HML84_12870	COG1228	amidohydrolase
HML84_12875	COG0402	S-adenosylhomocysteine deaminase activity
HML84_12900	COG0126	phosphoglycerate kinase activity
HML84_12925	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HML84_12985	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
HML84_13060	COG2884	Cell division ATP-binding protein ftsE
HML84_13065	COG2177	Part of the ABC transporter FtsEX involved in
HML84_13130	COG2813	Specifically methylates the guanine in position
HML84_13130	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HML84_13135	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HML84_13140	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HML84_13290	COG1028	Short-chain dehydrogenase reductase Sdr
HML84_13310	COG1116	anion transmembrane transporter activity
HML84_13320	COG0756	dUTP diphosphatase activity
HML84_13355	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HML84_13450	COG3608	succinylglutamate desuccinylase aspartoacylase
HML84_13460	COG1758	RNA polymerase activity
HML84_13490	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HML84_13580	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HML84_13760	COG1764	response to oxidative stress
HML84_13780	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HML84_13805	COG4771	TonB-dependent receptor
HML84_13810	COG4771	TonB-dependent receptor
HML84_13835	COG0642	Histidine kinase
HML84_13855	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HML84_13890	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HML84_13970	COG1047	Peptidyl-prolyl cis-trans
HML84_13980	COG0330	HflC and HflK could
HML84_14105	COG0189	ligase activity
HML84_14105	COG4067	protein conserved in archaea
HML84_14120	COG0110	maltose O-acetyltransferase activity
HML84_14130	COG2818	Glycosylase
HML84_14200	COG2916	Histone family protein nucleoid-structuring protein H-NS
HML84_14225	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HML84_14230	COG0594	ribonuclease P activity
HML84_14275	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HML84_14370	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HML84_14375	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HML84_14395	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HML84_14435	COG4221	oxidoreductase activity
HML84_14520	COG1309	transcriptional regulator
HML84_14535	COG1960	acyl-CoA dehydrogenase activity
HML84_14580	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
HML84_14585	COG1607	acyl-coa hydrolase
HML84_14615	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HML84_14620	COG0704	Plays a role in the regulation of phosphate uptake
HML84_14625	COG0640	Transcriptional regulator
HML84_14655	COG2119	membrane
HML84_14665	COG2900	Belongs to the SlyX family
HML84_14695	COG1773	rubredoxin
HML84_14805	COG0668	transmembrane transport
HML84_14865	COG5285	phytanoyl-CoA dioxygenase
HML84_14875	COG1960	acyl-CoA dehydrogenase activity
HML84_14940	COG2212	antiporter activity
HML84_14945	COG1320	monovalent cation:proton antiporter activity
HML84_14995	COG2267	carboxylic ester hydrolase activity
HML84_15085	COG4964	Belongs to the GSP D family
HML84_15170	COG0783	Belongs to the Dps family
HML84_15175	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HML84_15380	COG3245	cytochrome
HML84_15415	COG1028	Short-chain dehydrogenase reductase Sdr
HML84_15430	COG2960	long-chain fatty acid transporting porin activity
HML84_15435	COG0347	Belongs to the P(II) protein family
HML84_15440	COG0004	ammonium transporteR
HML84_15455	COG2995	paraquat-inducible protein a
HML84_15565	COG0521	Mo-molybdopterin cofactor biosynthetic process
HML84_15610	COG1047	Peptidyl-prolyl cis-trans
HML84_15620	COG0288	reversible hydration of carbon dioxide
HML84_15635	COG2132	Multicopper oxidase
HML84_15645	COG2132	Multicopper oxidase
HML84_15670	COG2204	response regulator
HML84_15710	COG0347	Belongs to the P(II) protein family
HML84_15830	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HML84_15935	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HML84_15960	COG0713	ATP synthesis coupled electron transport
HML84_15975	COG1007	ATP synthesis coupled electron transport
HML84_16090	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HML84_16165	COG0745	RESPONSE REGULATOR receiver
HML84_16195	COG0165	Argininosuccinate lyase
HML84_16330	COG1215	transferase activity, transferring glycosyl groups
HML84_16355	COG3562	capsule polysaccharide
HML84_16375	COG1560	Kdo2-lipid A biosynthetic process
HML84_16420	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HML84_16485	COG3098	single-species biofilm formation
HML84_16490	COG0546	phosphoglycolate phosphatase activity
HML84_16555	COG3712	iron ion homeostasis
HML84_16580	COG2608	mercury ion transmembrane transporter activity
HML84_16625	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HML84_16635	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HML84_16645	COG0625	glutathione transferase activity
HML84_16680	COG1011	Hydrolase
HML84_16730	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HML84_16785	COG2366	antibiotic biosynthetic process
HML84_16800	COG2267	carboxylic ester hydrolase activity
HML84_16810	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HML84_16835	COG3830	Belongs to the UPF0237 family
HML84_16835	COG0560	Phosphoserine phosphatase
HML84_16865	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
HML84_16900	COG0802	atpase or kinase
HML84_16905	COG0860	N-Acetylmuramoyl-L-alanine amidase
HML84_16925	COG1923	regulation of RNA biosynthetic process
HML84_16965	COG0745	RESPONSE REGULATOR receiver
HML84_16985	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HML84_17040	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HML84_17045	COG0359	binds to the 23S rRNA
HML84_17080	COG0840	transmembrane signaling receptor activity
HML84_17090	COG2226	methyltransferase
HML84_17095	COG5001	Diguanylate cyclase
HML84_17095	COG3706	GGDEF domain
HML84_17095	COG2203	Gaf domain
HML84_17095	COG4251	negative regulation of phosphorylation
HML84_17115	COG1595	DNA-templated transcription, initiation
HML84_17155	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HML84_17165	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HML84_17165	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HML84_17175	COG3706	GGDEF domain
HML84_17190	COG3460	Phenylacetate-CoA oxygenase
HML84_17195	COG3396	Phenylacetate-CoA oxygenase
HML84_17200	COG2151	metal-sulfur cluster biosynthetic enzyme
HML84_17265	COG3093	addiction module antidote protein HigA
HML84_17290	COG3093	addiction module antidote protein HigA
HML84_17350	COG1028	Short-chain dehydrogenase reductase Sdr
HML84_17375	COG0456	acetyltransferase
HML84_17380	COG0842	Transport permease protein
HML84_17395	COG1053	succinate dehydrogenase
HML84_17400	COG1053	succinate dehydrogenase
HML84_17400	COG3976	FMN-binding domain protein
HML84_17445	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HML84_17505	COG0583	DNA-binding transcription factor activity
HML84_17590	COG2050	protein possibly involved in aromatic compounds catabolism
HML84_17650	COG1846	Transcriptional regulator
HML84_17665	COG0446	pyridine nucleotide-disulphide oxidoreductase
HML84_17685	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HML84_17705	COG3473	Maleate cis-trans isomerase
HML84_17710	COG0596	Alpha beta hydrolase
HML84_17755	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HML84_17760	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HML84_17770	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HML84_17775	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HML84_17780	COG0142	geranyltranstransferase activity
HML84_17840	COG0662	Cupin 2, conserved barrel domain protein
HML84_17855	COG1846	Transcriptional regulator
HML84_17865	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HML84_17905	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HML84_17915	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HML84_17960	COG0537	adenosine 5'-monophosphoramidase activity
HML84_18035	COG2835	tetraacyldisaccharide 4'-kinase activity
HML84_18090	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HML84_18100	COG1959	2 iron, 2 sulfur cluster binding
HML84_18160	COG2070	2-Nitropropane dioxygenase
HML84_18255	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HML84_18265	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HML84_18280	COG0617	tRNA 3'-terminal CCA addition
HML84_18335	COG2967	ApaG domain
HML84_18370	COG3178	'Phosphotransferase
HML84_18415	COG1845	cytochrome c oxidase, subunit III
HML84_18435	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
HML84_18460	COG0134	indole-3-glycerol-phosphate synthase activity
HML84_18490	COG1765	OsmC-like protein
HML84_18500	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
HML84_18520	COG2198	Histidine kinase
HML84_18520	COG2205	protein histidine kinase activity
HML84_18520	COG0784	Response regulator, receiver
HML84_18555	COG0151	Belongs to the GarS family
HML84_18560	COG0138	bifunctional purine biosynthesis protein purh
HML84_18605	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HML84_18685	COG3047	cAMP biosynthetic process
HML84_18695	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HML84_18810	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HML84_18835	COG0811	peptide transport
HML84_18840	COG3015	lipoprotein NlpE involved in copper resistance
HML84_18850	COG1595	DNA-templated transcription, initiation
HML84_18945	COG3209	COG3209 Rhs family protein
HML84_18965	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HML84_19025	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HML84_19060	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HML84_19060	COG3453	Protein conserved in bacteria
HML84_19095	COG4208	sulfate ABC transporter
HML84_19180	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HML84_19260	COG1704	LemA family
HML84_19345	COG3813	Protein conserved in bacteria
HML84_19350	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HML84_19485	COG2166	iron-sulfur cluster assembly
HML84_19490	COG2151	metal-sulfur cluster biosynthetic enzyme
HML84_19495	COG0316	Belongs to the HesB IscA family
HML84_19505	COG0719	Fe-S assembly protein
HML84_19525	COG0105	UTP biosynthetic process
HML84_19860	COG1733	regulation of RNA biosynthetic process
HML84_19915	COG0789	Transcriptional regulator
HML84_19920	COG0583	DNA-binding transcription factor activity
HML84_19985	COG2944	sequence-specific DNA binding
HML84_20095	COG0402	S-adenosylhomocysteine deaminase activity
HML84_20100	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HML84_20105	COG1116	anion transmembrane transporter activity
HML84_20150	COG1012	belongs to the aldehyde dehydrogenase family
HML84_20315	COG3323	Protein of unknown function (DUF1653)
HML84_20315	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HML84_20335	COG1752	Esterase of the alpha-beta hydrolase superfamily
HML84_20375	COG3210	domain, Protein
HML84_20380	COG3210	domain, Protein
HML84_20475	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HML84_20635	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
HML84_20635	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HML84_20640	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
HML84_20650	COG2030	dehydratase
HML84_20710	COG0745	RESPONSE REGULATOR receiver
HML84_20830	COG0071	Belongs to the small heat shock protein (HSP20) family
HML84_20835	COG3360	Dodecin
HML84_20925	COG0583	DNA-binding transcription factor activity
HML84_21075	COG2856	Zn peptidase
HML84_21130	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HML84_21235	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HML84_21250	COG2205	protein histidine kinase activity
HML84_21250	COG5002	protein histidine kinase activity
HML84_21250	COG0784	Response regulator, receiver
HML84_21285	COG3956	TIGRFAM MazG family protein
HML84_21305	COG0789	Transcriptional regulator
HML84_21310	COG3328	transposase activity
HML84_21320	COG3344	reverse transcriptase
HML84_21340	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HML84_21345	COG1138	Cytochrome C-type biogenesis protein
HML84_21370	COG0563	adenylate kinase activity
HML84_21435	COG0583	DNA-binding transcription factor activity
HML84_21455	COG4133	protoheme IX ABC transporter activity
HML84_21570	COG2911	Protein conserved in bacteria
HML84_21570	COG3210	domain, Protein
HML84_21575	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HML84_21615	COG0778	Nitroreductase
HML84_21650	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HML84_21655	COG2267	carboxylic ester hydrolase activity
HML84_21665	COG0667	Aldo Keto reductase
HML84_21735	COG0559	Belongs to the binding-protein-dependent transport system permease family
HML84_21780	COG1960	acyl-CoA dehydrogenase activity
HML84_21790	COG1309	transcriptional regulator
HML84_21815	COG1028	Short-chain dehydrogenase reductase Sdr
HML84_21950	COG3284	Transcriptional regulator
HML84_21955	COG3829	transcription factor binding
HML84_21980	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family