locus-tag class description P40_00005 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) P40_00010 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) P40_00015 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) P40_00020 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) P40_00025 ENOG4105VFQ Histone family protein nucleoid-structuring protein H-NS P40_00035 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase P40_00055 ENOG41083Z3 extracellular ligand-binding receptor P40_00065 ENOG4108IV0 ABC, transporter P40_00070 ENOG4105C38 Glycyl-tRNA synthetase beta subunit P40_00080 ENOG4108R3E Dna-3-methyladenine glycosylase i P40_00085 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) P40_00110 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) P40_00115 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase P40_00120 ENOG4105CQB FAD linked oxidase domain protein P40_00125 ENOG4108JQ1 Dehydrogenase P40_00150 ENOG4105CKD glutathione-regulated potassium-efflux system protein P40_00170 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) P40_00200 ENOG4107RGH Aldehyde dehydrogenase P40_00210 ENOG4107HP6 Transcriptional regulator P40_00230 ENOG4107QNJ CoA-transferase subunit B P40_00240 ENOG4105DNZ Alpha Beta Hydrolase P40_00255 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) P40_00260 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) P40_00265 ENOG41080HT Transcriptional regulator, arsr family P40_00280 ENOG4105EQ0 Major Facilitator superfamily P40_00285 ENOG4105C5Q Transcriptional regulator P40_00290 ENOG4107XDR Lactoylglutathione lyase P40_00295 ENOG4105D7A ATP-binding protein P40_00300 ENOG4108YZY peptidylprolyl cis-trans isomerase P40_00320 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) P40_00325 ENOG4105CBS Chea signal transduction histidine kinase P40_00330 ENOG4105BZU Histidine kinase P40_00335 ENOG4105C8Q Methyl-accepting chemotaxis P40_00340 ENOG4108ZGA chew protein P40_00345 ENOG4105M3Z response regulator P40_00350 ENOG4108UNF response regulator P40_00355 ENOG4105D7Z glutathione synthase P40_00365 ENOG4108UJU UPF0301 protein P40_00370 ENOG4107Y66 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) P40_00380 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) P40_00385 ENOG4105CXT aspartate transcarbamylase P40_00390 ENOG4105CD3 dihydroorotase P40_00395 ENOG4108KHN disulfide isomerase, thiol-disulfide oxidase P40_00400 ENOG4107ZT5 Thiol disulfide interchange protein P40_00405 ENOG4105XJC Two component transcriptional regulator (Winged helix family P40_00410 ENOG4105DHQ Histidine kinase P40_00425 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) P40_00430 ENOG4105CHF Glutathione S-transferase P40_00435 ENOG4105EUB pirin domain protein P40_00440 ENOG4105CZX twitching motility protein P40_00445 ENOG4105CZX twitching motility protein P40_00450 ENOG4105DFA alanine racemase domain protein P40_00455 ENOG4105II7 pyrroline-5-carboxylate reductase P40_00465 ENOG4108VIA integral membrane protein P40_00470 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase P40_00500 ENOG4105C1G acyl-Coa dehydrogenase P40_00520 ENOG4105EEF Alkane 1-monooxygenase P40_00535 ENOG4105CVP deoxyribo-dipyrimidine photolyase P40_00575 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase P40_00590 ENOG4105KEG ribosomal-protein-alanine acetyltransferase P40_00600 ENOG4105CGU Enoyl-CoA hydratase P40_00605 ENOG4105D2B acyl-CoA dehydrogenase P40_00610 ENOG4105C1G acyl-Coa dehydrogenase P40_00615 ENOG4105CHU acetyl-coa acetyltransferase P40_00630 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) P40_00635 ENOG4105C1A potassium transporter peripheral membrane P40_00640 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B P40_00645 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) P40_00650 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) P40_00660 ENOG4105C79 DNA protecting protein DprA P40_00665 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) P40_00670 ENOG4105DBS Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity) P40_00675 ENOG4105E2X shikimate dehydrogenase P40_00685 ENOG4108Z0R Transferase P40_00690 ENOG4105DGW oligopeptidase A P40_00705 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) P40_00735 ENOG4105DP0 ferredoxin-NADP reductase P40_00740 ENOG4105DUM transcriptional regulator, lysR family P40_00755 ENOG4105CB5 ATP-dependent DNA helicase recG P40_00760 ENOG4105C5Q Transcriptional regulator P40_00770 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) P40_00775 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit P40_00780 ENOG4105EBR Carboxylesterase P40_00795 ENOG4105KME endoribonuclease L-psp P40_00805 ENOG4105EQR Transposase IS116 IS110 IS902 P40_00810 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) P40_00815 ENOG4105VFG Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) P40_00820 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) P40_00825 ENOG4105E5N succinylglutamate desuccinylase aspartoacylase P40_00840 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F P40_00845 ENOG41062YB Trap dicarboxylate transporter, dctp subunit P40_00865 ENOG4105CG6 trap dicarboxylate transporter dctm subunit P40_00885 ENOG4105DSJ YicC domain protein P40_00890 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) P40_00895 ENOG4107QP2 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) P40_00905 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) P40_00910 ENOG4105CAS nag kinase P40_00920 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) P40_00930 ENOG4105W5Q DNA repair protein (RadC P40_00935 ENOG4105KDC 50s ribosomal protein l28 P40_00940 ENOG4105W0E 50S ribosomal protein L33 P40_01010 ENOG4107HP6 Transcriptional regulator P40_01020 ENOG410846T CoA-transferase family III P40_01035 ENOG4105CG6 trap dicarboxylate transporter dctm subunit P40_01065 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) P40_01085 ENOG4105BZS acriflavin resistance protein P40_01090 ENOG410624X efflux transporter, rnd family, mfp subunit P40_01095 ENOG4105CSA Coproporphyrinogen iii oxidase P40_01100 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) P40_01105 ENOG4105DWV Homoserine O-trans-acetylase P40_01110 ENOG4105DWV Homoserine O-trans-acetylase P40_01125 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) P40_01130 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) P40_01135 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) P40_01145 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) P40_01150 ENOG4105CRP Part of the ABC transporter FtsEX involved in P40_01155 ENOG4105CAK Cell division ATP-binding protein ftsE P40_01160 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) P40_01175 ENOG4106H78 methyltransferase P40_01195 ENOG4105NBK UPF0345 protein P40_01205 ENOG4105DQW permease for cytosine purines, uracil, thiamine, allantoin P40_01210 ENOG4105DZC cytosine deaminase P40_01215 ENOG4107QJQ Mate efflux family protein P40_01220 ENOG4105CH2 amidohydrolase P40_01230 ENOG4105C4W S-formylglutathione hydrolase P40_01240 ENOG4105EXG Transcriptional regulator P40_01250 ENOG4105SYT Methylenetetrahydrofolate reductase P40_01260 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP P40_01265 ENOG41080HT Transcriptional regulator, arsr family P40_01275 ENOG4105CV1 Transketolase (EC 2.2.1.1) P40_01280 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase P40_01285 ENOG4105BZA Phosphoglycerate kinase P40_01290 ENOG4105D2N Aldolase P40_01320 ENOG4105E66 phosphoriboisomerase A P40_01335 ENOG4105C7B Threonine dehydratase P40_01340 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase P40_01345 ENOG4105W8B Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity) P40_01355 ENOG4105E07 UPF0149 protein P40_01360 ENOG4107RAQ aminopeptidase P40_01365 ENOG4105D0A hydroxylase P40_01370 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family P40_01375 ENOG4107QKW extracellular solute-binding protein family 1 P40_01380 ENOG4107QVT Binding-protein-dependent transport systems, inner membrane component P40_01395 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) P40_01400 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) P40_01405 ENOG4107QK8 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor P40_01410 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor P40_01465 ENOG4108V5Q transglutaminase-like protein P40_01490 ENOG4105YAJ CopG Arc MetJ P40_01510 ENOG41090KQ Glyoxalase Bleomycin resistance protein (Dioxygenase P40_01545 ENOG4105DDY UPF0142 protein ycaO P40_01565 ENOG4108K3A Glutathione S-transferase P40_01590 ENOG41089UC methyltransferase, type 11 P40_01625 ENOG4105K5X acetyltransferase P40_01630 ENOG4105CYM Glutathione S-transferase P40_01700 ENOG4105CG6 trap dicarboxylate transporter dctm subunit P40_01705 ENOG4105C1G acyl-Coa dehydrogenase P40_01715 ENOG4108I7Y domain protein P40_01735 ENOG4108XC3 NADH ubiquinone oxidoreductase P40_01745 ENOG4105CYM Glutathione S-transferase P40_01785 ENOG4108KDQ Catalyzes hydrolytic cleavage of carbon-halogen bonds in halogenated aliphatic compounds, leading to the formation of the corresponding primary alcohols, halide ions and protons (By similarity) P40_01790 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA P40_01795 ENOG4105CRW Short chain fatty acid transporter P40_01810 ENOG4107RZC phospholipase d P40_01815 ENOG4105E0Y RtcB Protein P40_01870 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F P40_01880 ENOG4106MP8 UPF0754 membrane protein P40_01910 ENOG4105CG6 trap dicarboxylate transporter dctm subunit P40_01925 ENOG4108Z0R Transferase P40_01935 ENOG4105IFJ Histidine kinase P40_01940 ENOG4105XJC Two component transcriptional regulator (Winged helix family P40_01955 ENOG4105CEY Amp-dependent synthetase and ligase P40_01965 ENOG4105DH7 May be involved in recombination (By similarity) P40_01975 ENOG4105GRZ Ycii-related protein P40_01980 ENOG4105CHP RNA polymerase P40_02015 ENOG4105CGZ zinc metallopeptidase P40_02035 ENOG4105D9P serine threonine protein kinase P40_02040 ENOG4105TMB Formate nitrite transporter P40_02045 ENOG4105KHU inner membrane protein YohD P40_02050 ENOG4105CYM Glutathione S-transferase P40_02070 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) P40_02090 ENOG4105C1J atp-dependent rna helicase P40_02115 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) P40_02120 ENOG4105C59 p-type ATPase P40_02140 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) P40_02145 ENOG4108HRM phosphoenolpyruvate--protein phosphotransferase P40_02155 ENOG4105HF0 Membrane P40_02160 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) P40_02165 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) P40_02210 ENOG4105C5H ABC transporter P40_02220 ENOG4105KK4 UPF0060 membrane protein P40_02245 ENOG4105C1G acyl-Coa dehydrogenase P40_02260 ENOG4105C8Y Acetylornithine aminotransferase P40_02265 ENOG4107QX3 carboxylase P40_02270 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase P40_02280 ENOG4105CEY Amp-dependent synthetase and ligase P40_02285 ENOG4108V1T peptidylprolyl cis-trans isomerase P40_02290 ENOG4105PBF Anti-RNA polymerase sigma 70 factor P40_02305 ENOG41067MG lrgb family P40_02315 ENOG41080I0 Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity) P40_02320 ENOG4105D9M gamma-glutamylcysteine synthetase P40_02325 ENOG4105BZM domain protein P40_02330 ENOG4105M3Z response regulator P40_02335 ENOG4105DPZ Two component transcriptional regulator (Winged helix family P40_02340 ENOG4105E0F Histidine kinase P40_02345 ENOG4105F27 Major Facilitator P40_02350 ENOG4105C01 Dihydroxy-acid dehydratase P40_02360 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) P40_02365 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family P40_02375 ENOG4105D8V Glucose sorbosone dehydrogenase P40_02380 ENOG4105IU3 Glutathione S-transferase P40_02400 ENOG4105J7D transcriptional regulator P40_02420 ENOG4108SF5 RNA Polymerase P40_02425 ENOG4108S3W Anti-feci sigma factor, fecr P40_02430 ENOG4105D05 Receptor P40_02435 ENOG4105DZG Dehydrogenase P40_02440 ENOG4105CVE Lytic murein transglycosylase P40_02450 ENOG4105CEP NADH dehydrogenase P40_02455 ENOG4105CEY Amp-dependent synthetase and ligase P40_02465 ENOG4105C26 Dehydrogenase P40_02495 ENOG4108PHS Dehydrogenase P40_02515 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase P40_02520 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) P40_02525 ENOG4105VEJ Heat shock protein P40_02530 ENOG4107Y3D HAD-superfamily hydrolase subfamily IA variant 3 P40_02535 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family P40_02545 ENOG4107RK2 ADP-ribose diphosphatase NudE P40_02550 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase P40_02590 ENOG4105CEY Amp-dependent synthetase and ligase P40_02595 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component P40_02605 ENOG4105DEF Extracellular solute-binding protein, family 5 P40_02610 ENOG4108JQ7 (ABC) transporter P40_02625 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) P40_02630 ENOG4105F9U Dehydrogenase P40_02660 ENOG4107RN6 Monooxygenase P40_02685 ENOG4105C1G acyl-Coa dehydrogenase P40_02700 ENOG4105EAC phosphoserine phosphatase P40_02720 ENOG4105ECC imidazole-glycerol-phosphate dehydratase P40_02725 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) P40_02730 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase P40_02735 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) P40_02740 ENOG4108UPT UPF0178 protein P40_02745 ENOG4108YZN class I peptide chain release factor P40_02755 ENOG4105C09 Bile acid P40_02760 ENOG4107RNU major facilitator superfamily MFS_1 P40_02775 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) P40_02790 ENOG4108ZAF Molybdopterin P40_02795 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) P40_02800 ENOG4105CVM Molybdenum cofactor synthesis domain protein P40_02805 ENOG4105CN1 protease P40_02810 ENOG41063SB peptidase P40_02815 ENOG4107YZP Rhodanese domain protein P40_02820 ENOG4105VW4 glutaredoxin 3 P40_02825 ENOG4105IX2 One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity) P40_02830 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) P40_02855 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) P40_02860 ENOG4105E68 Sulfatase P40_02865 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) P40_02875 ENOG4105C5F glutamine synthetase P40_02890 ENOG4105CUX Signal transduction histidine kinase P40_02895 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family P40_02905 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) P40_02920 ENOG4105EUK rtx toxin RtxA P40_02930 ENOG4105X8U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) P40_02935 ENOG4105WKS Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) P40_02940 ENOG4105KPZ phosphoribosyl-atp pyrophosphatase P40_02945 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) P40_02955 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) P40_02965 ENOG4107QZM n-acetylglutamate synthase P40_02970 ENOG4105CJ3 phosphate transporter P40_02975 ENOG4107IX6 phosphate transport regulator P40_02980 ENOG4107QHF type ii secretion system protein e P40_02985 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) P40_02990 ENOG4105CM2 brancheD-chain amino acid aminotransferase P40_02995 ENOG4105XA0 heptosyltransferase ii P40_03005 ENOG4105D16 lipopolysaccharide heptosyltransferase i P40_03010 ENOG4107RJ7 Glycosyl transferase (Group 1 P40_03015 ENOG4107543 (lipo)polysaccharide P40_03045 ENOG4105D1S lipid A biosynthesis P40_03055 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) P40_03060 ENOG4108MIW Induces the synthesis of acid phosphatase (AppA) and several other polypeptides (such as AppBC) during the deceleration phase of growth. It also acts as a transcriptional repressor for one group of proteins that are synthesized preferentially in exponential growth and for one group synthesized only in the stationary phase. Also involved in the stabilization of the sigma stress factor RpoS during stress conditions P40_03065 ENOG4107RN6 Monooxygenase P40_03070 ENOG4105CPC Aldo Keto reductase P40_03075 ENOG41087SS fad dependent oxidoreductase P40_03080 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase P40_03085 ENOG4105DFG type I secretion outer membrane protein P40_03090 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) P40_03095 ENOG41087AY ADP-Ribose pyrophosphatase P40_03105 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) P40_03130 ENOG4108JA1 polyketide synthase P40_03135 ENOG4105CG6 trap dicarboxylate transporter dctm subunit P40_03145 ENOG4108NDG TRAP dicarboxylate P40_03160 ENOG4105BZU Histidine kinase P40_03165 ENOG4105KCV RNA signal recognition particle 4.5S RNA P40_03170 ENOG4105EAM Na Pi-cotransporter P40_03175 ENOG4105IPS esterase P40_03180 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) P40_03185 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) P40_03190 ENOG4106HNH Acyl-transferase P40_03200 ENOG4105IUQ nucleoprotein polynucleotide-associated enzyme P40_03210 ENOG4107SQI penicillin amidase P40_03215 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) P40_03230 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) P40_03235 ENOG4105CAP With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P (By similarity) P40_03240 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) P40_03245 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein P40_03255 ENOG4105BZU Histidine kinase P40_03280 ENOG4105E39 Enoyl-CoA hydratase P40_03305 ENOG4105CG6 trap dicarboxylate transporter dctm subunit P40_03310 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) P40_03315 ENOG4105CBN LysR family transcriptional regulator P40_03320 ENOG4105CPC Aldo Keto reductase P40_03325 ENOG4105ETT transcriptional Regulator, LysR family P40_03330 ENOG4105CGU Enoyl-CoA hydratase P40_03350 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) P40_03355 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase P40_03360 ENOG4105CF7 AraC family transcriptional regulator P40_03365 ENOG4105C1P efflux transporter, rnd family, mfp subunit P40_03375 ENOG4105ENJ RND efflux system, outer membrane lipoprotein P40_03380 ENOG4105FFC UPF0187 protein P40_03385 ENOG4105EW6 flavin reductase domain protein, FMN-binding P40_03390 ENOG4105Q26 Siderophore-interacting protein P40_03395 ENOG4107MHI Transcriptional regulator, MarR family P40_03400 ENOG4105EEF Alkane 1-monooxygenase P40_03405 ENOG4108ZX5 transcriptional regulator P40_03415 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) P40_03420 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) P40_03435 ENOG41084HI prevent-host-death family P40_03450 ENOG4108IV0 ABC, transporter P40_03455 ENOG4105C0Z ABC transporter P40_03465 ENOG4105C32 Amino acid ABC transporter (Permease) P40_03475 ENOG4105DRR Transcriptional regulator, GntR family P40_03480 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase P40_03490 ENOG4105SKE transcriptional Regulator LysR family P40_03515 ENOG4105DCY Is an aliphatic amidase with a restricted substrate specificity, as it only hydrolyzes formamide (By similarity) P40_03525 ENOG4108JQ9 ABC transporter P40_03530 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) P40_03540 ENOG410908U Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) P40_03555 ENOG4105KMG Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes (By similarity) P40_03560 ENOG4105CEN a g-specific adenine glycosylase P40_03575 ENOG4105DJ4 phosphatidylserine decarboxylase P40_03580 ENOG4105KHC sulfurtransferase P40_03585 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) P40_03590 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) P40_03605 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) P40_03610 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) P40_03615 ENOG4105K8N protein family UPF0079, ATPase P40_03620 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase P40_03625 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) P40_03630 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) P40_03635 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) P40_03640 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) P40_03645 ENOG4107QJR hflk protein P40_03650 ENOG4105EPW hflc protein P40_03660 ENOG4105C49 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity) P40_03665 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis P40_03680 ENOG4105G6Z alkaline phosphatase P40_03685 ENOG4105G6Z alkaline phosphatase P40_03710 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) P40_03715 ENOG4105C2N RNA methyltransferase TrmH family group 3 P40_03720 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) P40_03730 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) P40_03735 ENOG4105K9Q Binds to the 23S rRNA (By similarity) P40_03740 ENOG4105CDU Replicative dna helicase P40_03745 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) P40_03750 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) P40_03760 ENOG4105CZN Potassium uptake protein P40_03765 ENOG4108VN5 Inherit from COG: PepSY-associated TM helix P40_03810 ENOG4105EMN RNA polymerase sigma factor P40_03815 ENOG4105C5H ABC transporter P40_03820 ENOG4105C8Q Methyl-accepting chemotaxis P40_03825 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) P40_03835 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) P40_03840 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) P40_03860 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) P40_03870 ENOG4105CRS phenylacetate-CoA oxygenase PaaG subunit P40_03875 ENOG4105N76 Phenylacetate-CoA oxygenase, subunit P40_03880 ENOG4105D9S phenylacetate-CoA oxygenase PaaI subunit P40_03885 ENOG4108ZA2 phenylacetate-CoA oxygenase PaaJ subunit P40_03890 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) P40_03895 ENOG4105DXM phenylacetic acid degradation protein P40_03915 ENOG4108R4U Hnh endonuclease P40_03935 ENOG4105CGH 5'-nucleotidase P40_03940 ENOG4105KEG ribosomal-protein-alanine acetyltransferase P40_03960 ENOG4108IV0 ABC, transporter P40_03965 ENOG4105C0Z ABC transporter P40_03970 ENOG4105CF8 branched-chain amino acid ABC transporter, permease P40_03975 ENOG4105C32 Amino acid ABC transporter (Permease) P40_03985 ENOG4105V9J phenylacetic acid degradation operon negative regulatory protein P40_03990 ENOG4108UKI Enoyl-CoA hydratase P40_03995 ENOG4108ZJI phenylacetic acid degradation protein P40_04000 ENOG4105CHU acetyl-coa acetyltransferase P40_04005 ENOG4105DZS Phenylacetate-CoA ligase P40_04035 ENOG4105ETT transcriptional Regulator, LysR family P40_04040 ENOG4107U5X Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) P40_04055 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) P40_04060 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) P40_04065 ENOG4107YIM Involved in the transcription termination process (By similarity) P40_04070 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) P40_04075 ENOG4108ZAI phosphatidylglycerophosphatase a P40_04080 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) P40_04085 ENOG4105CTB Polyprenyl synthetase P40_04105 ENOG4105CK6 Two component transcriptional regulator (Winged helix family P40_04110 ENOG4105X0I Fimbrial P40_04115 ENOG4108VEV chaperone P40_04125 ENOG4108WDE Fimbrial protein P40_04135 ENOG4105BZU Histidine kinase P40_04145 ENOG4107QN1 sodium solute P40_04165 ENOG4105BZU Histidine kinase P40_04175 ENOG4108Z6K Catalyzes the circularization of gamma-N-acetyl- alpha,gamma-diaminobutyric acid (ADABA) to ectoine (1,4,5,6- tetrahydro-2-methyl-4-pyrimidine carboxylic acid), which is an excellent osmoprotectant (By similarity) P40_04180 ENOG4108JPW Aminotransferase P40_04190 ENOG4108V8F Transcriptional regulator, MarR family P40_04195 ENOG4105CK7 Sodium proline symporter P40_04205 ENOG4105DZA Converts GTP to 7,8-dihydroneopterin triphosphate (By similarity) P40_04220 ENOG4105UGU tonB-dependent Receptor P40_04235 ENOG4105C8N cysteinyl-tRNA synthetase P40_04240 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase P40_04245 ENOG4105C22 threonyL-tRNA synthetase P40_04250 ENOG4108ESY Metal dependent phosphohydrolase P40_04250 ENOG4108ESY Metal dependent phosphohydrolase P40_04290 ENOG4108RMV DegV Family P40_04320 ENOG4107RN6 Monooxygenase P40_04340 ENOG4108UVJ appr-1-p processing domain protein P40_04345 ENOG4108RWI nicotinamidase P40_04355 ENOG4105HDD phospholipase P40_04360 ENOG4105W49 UPF0434 protein P40_04365 ENOG4105CSU acyl-Coa dehydrogenase P40_04370 ENOG4105WD1 Membrane P40_04375 ENOG4105CSU acyl-Coa dehydrogenase P40_04395 ENOG4105E02 MotA TolQ exbB proton channel P40_04425 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) P40_04465 ENOG4105VJY transcriptional regulator P40_04545 ENOG4105CKW Inner membrane protein yedI P40_04555 ENOG4105CGU Enoyl-CoA hydratase P40_04585 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) P40_04595 ENOG4105VCC 30S ribosomal protein S21 P40_04600 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) P40_04605 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) P40_04610 ENOG4107ZVW dihydroneopterin aldolase P40_04615 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase P40_04625 ENOG4105CHR reductase P40_04630 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate P40_04635 ENOG4105EA8 2-Nitropropane dioxygenase P40_04640 ENOG4105ED1 spovr family P40_04645 ENOG4106AKX UPF0229 protein P40_04650 ENOG4105CYN Serine protein kinase P40_04660 ENOG4105NWN ApaG protein P40_04665 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) P40_04670 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) P40_04675 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) P40_04680 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) P40_04685 ENOG4105EHM Aminoglycoside phosphotransferase P40_04690 ENOG4108S0S Nucleotidyl transferase P40_04695 ENOG4105DJV ribulose-phosphate 3-epimerase P40_04705 ENOG4108QBX (LipO)protein P40_04720 ENOG4105CSH Transporter P40_04725 ENOG4105E2S oxidase) subunit II P40_04730 ENOG4105BZ9 Cytochrome C oxidase, subunit I P40_04735 ENOG4105CCU oxidase (Subunit III) P40_04740 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) P40_04750 ENOG4105TX3 Histidine kinase P40_04755 ENOG4108UYB regulatoR P40_04760 ENOG4105CRQ synthase (Component I) P40_04765 ENOG4105DDQ anthranilate synthase P40_04770 ENOG4108I0Q anthranilate phosphoribosyltransferase P40_04775 ENOG4105DK0 Indole-3-glycerol phosphate synthase P40_04780 ENOG4107RYR Transcriptional regulator, Crp Fnr family P40_04785 ENOG4108UKZ OsmC family P40_04790 ENOG4105FDS Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) P40_04795 ENOG4108S0N Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol (By similarity) P40_04800 ENOG4105BZU Histidine kinase P40_04805 ENOG4105EYW Ion transport protein P40_04810 ENOG4105P69 integral membrane protein P40_04815 ENOG4105C12 Phosphoribosylglycinamide synthetase P40_04820 ENOG4105DC1 bifunctional purine biosynthesis protein purh P40_04825 ENOG4105VY0 Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters (By similarity) P40_04830 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) P40_04840 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) P40_04855 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase P40_04860 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein P40_04865 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) P40_04870 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) P40_04880 ENOG4105DA6 Catalyzes the conversion of 5-methoxyuridine (mo5U) to uridine-5-oxyacetic acid (cmo5U) at position 34 in tRNA. May also participate in the methylation of uridine-5-oxyacetic acid (cmo5U) to uridine-5-oxyacetic acid methyl ester (mcmo5U) (By similarity) P40_04895 ENOG4108ZX5 transcriptional regulator P40_04900 ENOG4105XJC Two component transcriptional regulator (Winged helix family P40_04905 ENOG4105DHQ Histidine kinase P40_04925 ENOG4105CEY Amp-dependent synthetase and ligase P40_04935 ENOG4105F0N pyrophosphate phospho-hydrolase P40_04940 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) P40_04945 ENOG4105C2W permease P40_04990 ENOG4105CTQ phosphohexokinase P40_05005 ENOG4105DFU Cell wall formation (By similarity) P40_05010 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase P40_05015 ENOG41067XB TonB family P40_05035 ENOG4107EII Lipoprotein involved with copper homeostasis and adhesion P40_05060 ENOG4108ZT1 Transcriptional regulator P40_05065 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) P40_05070 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) P40_05080 ENOG4105F0I Aminotransferase P40_05085 ENOG4105DZ1 carboxypeptidase P40_05095 ENOG4105CVE Lytic murein transglycosylase P40_05100 ENOG4105CNI cell division protein FtsW P40_05105 ENOG4105CJN penicillin-binding protein P40_05110 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) P40_05125 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) P40_05145 ENOG4105C8T Leucyl-tRNA synthetase P40_05155 ENOG4105C8P )-transporter P40_05160 ENOG4105CHH sulfate transporter P40_05165 ENOG4107S7U Sulfide dehydrogenase P40_05180 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) P40_05185 ENOG4108V7B Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide (By similarity) P40_05190 ENOG4108JU5 Magnesium and cobalt efflux protein P40_05195 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) P40_05200 ENOG4105C9A Phoh family P40_05205 ENOG4108IJ6 ABC transporter P40_05210 ENOG4105ECW sulfate abc transporter P40_05220 ENOG4108I5D sulfate abc transporter P40_05225 ENOG4108J2H Sulfate ABC transporter periplasmic sulfate-binding protein P40_05230 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) P40_05235 ENOG4108ZX6 Electron transport protein SCO1 SenC P40_05275 ENOG4108IAB Phoh family P40_05285 ENOG4105EIF outer membrane protein W P40_05290 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) P40_05325 ENOG4107RJ1 sodium solute P40_05330 ENOG4105VEQ Cold shock protein P40_05345 ENOG4105D0M Protease HtpX homolog P40_05350 ENOG4108V0P LemA family P40_05355 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) P40_05360 ENOG4107TQK Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group (By similarity) P40_05380 ENOG4105I08 Pseudouridine synthase P40_05385 ENOG4107QS1 Cytochrome C Oxidase, Subunit III P40_05390 ENOG4105FT1 Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I (By similarity) P40_05395 ENOG4105BZ9 Cytochrome C oxidase, subunit I P40_05430 ENOG4105BZK Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity) P40_05465 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) P40_05470 ENOG4105IJJ transcriptional regulator, crp fnr family P40_05475 ENOG4108IQE Amp-dependent synthetase and ligase P40_05480 ENOG4105C0Z ABC transporter P40_05485 ENOG4105C32 Amino acid ABC transporter (Permease) P40_05500 ENOG4108IV0 ABC, transporter P40_05510 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family P40_05520 ENOG4105CHR reductase P40_05525 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase P40_05540 ENOG4105E2Y ABC, transporter P40_05545 ENOG4105DG7 nitrate ABC transporter P40_05570 ENOG41082IR Excinuclease ABC C subunit domain protein P40_05580 ENOG4105HA9 of methanol dehydrogenase type P40_05605 ENOG4105VN1 Heat shock protein P40_05630 ENOG4105CMM transposase P40_05640 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family P40_05645 ENOG4105C3J Cysteine desulfurase P40_05655 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) P40_05660 ENOG4105VG1 fes assembly suf system protein P40_05665 ENOG4108Z4V iron-sulfur cluster assembly P40_05670 ENOG4105C9B Cysteine desulfurase P40_05675 ENOG4105JRK feS assembly protein SufD P40_05690 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) P40_05695 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs P40_05710 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) P40_05715 ENOG4105CUT histidyl-tRNA synthetase P40_05725 ENOG4105CNE Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) P40_05730 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) P40_05735 ENOG4107RNH Outer membrane receptor FepA P40_05745 ENOG4105BZU Histidine kinase P40_05750 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) P40_05755 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) P40_05760 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) P40_05770 ENOG4105PGM cation diffusion facilitator family transporter P40_05815 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) P40_05835 ENOG4105D78 K07001 NTE family protein P40_05840 ENOG4105EUB pirin domain protein P40_05845 ENOG410645S MarR family Transcriptional regulator P40_05880 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving P40_05890 ENOG4105YAJ CopG Arc MetJ P40_05940 ENOG4105DMF Dehydrogenase P40_05985 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) P40_06010 ENOG4107YPT transcriptional regulator P40_06065 ENOG4105FTV AraC Family Transcriptional Regulator P40_06075 ENOG4105E33 succinate dehydrogenase P40_06085 ENOG4106M28 alanine racemase domain protein P40_06100 ENOG4105E7U AraC family transcriptional regulator P40_06120 ENOG410756H nucleotidyltransferase P40_06140 ENOG410829K Lysine exporter protein (Lyse ygga) P40_06145 ENOG4108RXX maleylacetoacetate isomerase P40_06165 ENOG4107R7Y intracellular protease Pfpi family P40_06170 ENOG4105DVW rieske (2Fe-2S) P40_06180 ENOG4105CPC Aldo Keto reductase P40_06210 ENOG4105CEI nitrite reductase P40_06255 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) P40_06260 ENOG4105FYA Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) P40_06280 ENOG4105DZG Dehydrogenase P40_06290 ENOG4105C57 major facilitator superfamily P40_06300 ENOG4105ETT transcriptional Regulator, LysR family P40_06305 ENOG4105C1G acyl-Coa dehydrogenase P40_06310 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F P40_06315 ENOG4105GRZ Ycii-related protein P40_06340 ENOG4105CBN LysR family transcriptional regulator P40_06345 ENOG4108RZE Tetr family transcriptional regulator P40_06360 ENOG4105DFA alanine racemase domain protein P40_06365 ENOG4105CSW GntR family transcriptional regulator P40_06370 ENOG4108IND Tetr family transcriptional regulator P40_06375 ENOG4105F6U Short-chain dehydrogenase reductase Sdr P40_06380 ENOG4108RYK Nad-dependent epimerase dehydratase P40_06385 ENOG4105JQN Transcriptional regulator P40_06400 ENOG4105DIK (ABC) transporter P40_06405 ENOG4105CC5 ABC transporter P40_06410 ENOG4105CC5 ABC transporter P40_06415 ENOG4108VGI doxx family P40_06420 ENOG4105F2V VRR-NUC domain-containing protein P40_06435 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) P40_06450 ENOG4105E39 Enoyl-CoA hydratase P40_06455 ENOG4105NQN cytochrome C P40_06460 ENOG4105CHU acetyl-coa acetyltransferase P40_06475 ENOG4108WUH Transcriptional regulator, TetR family P40_06500 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR P40_06505 ENOG4108Z6B deaminase P40_06510 ENOG4105CHQ Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity) P40_06515 ENOG4108ETH Formylglycinamide ribotide synthetase P40_06525 ENOG4105EGD dinuclear metal center protein, YbgI family P40_06530 ENOG4105E09 nadh pyrophosphatase P40_06535 ENOG4105P8F nudix hydrolase P40_06540 ENOG4108Z0R Transferase P40_06550 ENOG4105D78 K07001 NTE family protein P40_06555 ENOG4108JU6 CBS domain protein P40_06565 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY P40_06570 ENOG4105K5M 30s ribosomal protein S16 P40_06575 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) P40_06580 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) P40_06585 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) P40_06590 ENOG4105Y3U Transglycosylase-associated protein P40_06595 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) P40_06600 ENOG4105T95 Thiol disulfide interChange protein P40_06605 ENOG4105CHM Aminotransferase P40_06610 ENOG4105D6E homoserine dehydrogenase P40_06625 ENOG4105EQR Transposase IS116 IS110 IS902 P40_06645 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F P40_06650 ENOG4105FE8 tRNA (Guanosine-2'-O-)-methyltransferase P40_06655 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) P40_06660 ENOG4105C0H protease P40_06690 ENOG4108JQB penicillin-binding protein 1C P40_06715 ENOG4105C5H ABC transporter P40_06725 ENOG4105EGS Mechanosensitive ion channel P40_06740 ENOG4105D4F Synthesizes selenophosphate from selenide and ATP (By similarity) P40_06745 ENOG4105CR7 Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA (By similarity) P40_06755 ENOG4105EJ2 Transcriptional regulator P40_06770 ENOG4108ZX5 transcriptional regulator P40_06775 ENOG4108ZK4 sdia-regulated domain-containing protein P40_06780 ENOG4108YH1 overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7 P40_06785 ENOG4105CHR reductase P40_06790 ENOG4105CHU acetyl-coa acetyltransferase P40_06795 ENOG4105C29 acyl-CoA thioesterase P40_06810 ENOG4105XJC Two component transcriptional regulator (Winged helix family P40_06815 ENOG4105IFJ Histidine kinase P40_06825 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase P40_06830 ENOG4105C1G acyl-Coa dehydrogenase P40_06835 ENOG4105C1G acyl-Coa dehydrogenase P40_06845 ENOG4105CDV Ompa motb domain protein P40_06860 ENOG4105BZG amino acid carrier protein P40_06865 ENOG4105ECQ AraC Family Transcriptional Regulator P40_06890 ENOG4105WKW Pfam:DUF1458 P40_06895 ENOG4105C1J atp-dependent rna helicase P40_06920 ENOG410804D Sensor Signal Transduction Histidine Kinase P40_06925 ENOG4105D05 Receptor P40_06935 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) P40_06940 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B P40_06950 ENOG4105E0K tonB-dependent siderophore receptor P40_06970 ENOG4105C5H ABC transporter P40_06975 ENOG4105C2I pirin domain protein P40_07020 ENOG4105CHU acetyl-coa acetyltransferase P40_07025 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase P40_07030 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) P40_07045 ENOG4105CRK lysyL-tRNA synthetase P40_07055 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) P40_07065 ENOG4105EA8 2-Nitropropane dioxygenase P40_07070 ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) P40_07085 ENOG4108IYU L-aspartate oxidase P40_07090 ENOG4105EMN RNA polymerase sigma factor P40_07100 ENOG4105VQK sigma E regulatory protein, MucB RseB P40_07110 ENOG4105C0H protease P40_07115 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) P40_07120 ENOG4105C3F Signal peptidase i P40_07130 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) P40_07135 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) P40_07140 ENOG41071DT Involved in DNA repair and RecF pathway recombination (By similarity) P40_07145 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) P40_07160 ENOG4105BZU Histidine kinase P40_07165 ENOG4105C6T cysteine synthase P40_07175 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) P40_07180 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) P40_07185 ENOG4105DXN mazG family P40_07195 ENOG4105W1Y Transcriptional regulator P40_07225 ENOG4108RKI Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length (By similarity) P40_07230 ENOG4105DA4 cytochrome c-type biogenesis protein P40_07235 ENOG4107QX9 Thiol disulfide interChange protein P40_07240 ENOG4105KWW Biogenesis protein P40_07250 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) P40_07260 ENOG4108UQY Iron-storage protein P40_07275 ENOG4107QSA Oxaloacetate decarboxylase P40_07280 ENOG4105D9Q decarboxylase (Beta subunit) P40_07300 ENOG4105DG7 nitrate ABC transporter P40_07305 ENOG4105D7T ABC transporter P40_07320 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) P40_07325 ENOG4105DZ2 Transcriptional regulator P40_07330 ENOG4105KPY Small multidrug resistance protein P40_07335 ENOG41080ZE Adenylate cyclase P40_07340 ENOG4107EV4 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity) P40_07345 ENOG4105CA5 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity) P40_07350 ENOG41060IM Heme exporter protein P40_07355 ENOG41067VX Heme exporter protein P40_07360 ENOG4108ZKK Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH (By similarity) P40_07365 ENOG4105DKB L-sorbosone dehydrogenase P40_07370 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) P40_07410 ENOG4105CHR reductase P40_07445 ENOG4105DA5 (ABC) transporter P40_07450 ENOG4105E3A (ABC) transporter P40_07455 ENOG4107R1K Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) P40_07470 ENOG4105CFC Transporter P40_07475 ENOG4105F8J Adenylate Guanylate cyclase P40_07480 ENOG41069NU Nitroreductase P40_07505 ENOG4105VDM plasmid maintenance system antidote protein, xre family P40_07520 ENOG4108821 RND type efflux pump P40_07545 ENOG4105D74 hydrolase P40_07565 ENOG4105C32 Amino acid ABC transporter (Permease) P40_07575 ENOG4105C0Z ABC transporter P40_07580 ENOG4108IV0 ABC, transporter P40_07585 ENOG4105CEY Amp-dependent synthetase and ligase P40_07590 ENOG4105CSP Major Facilitator Superfamily P40_07600 ENOG4105CHU acetyl-coa acetyltransferase P40_07605 ENOG4105KF3 Short-chain dehydrogenase reductase Sdr P40_07615 ENOG4105D2B acyl-CoA dehydrogenase P40_07620 ENOG4105CC9 acyl-Coa dehydrogenase P40_07625 ENOG4108IG5 Transcriptional regulator P40_07630 ENOG4105E39 Enoyl-CoA hydratase P40_07650 ENOG41061TZ Short-chain dehydrogenase reductase Sdr P40_07670 ENOG4105ES4 Nitrilase P40_07675 ENOG4108JUB Transcriptional regulator P40_07710 ENOG4105BZU Histidine kinase P40_07725 ENOG4105DZG Dehydrogenase P40_07740 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) P40_07745 ENOG4105C26 Dehydrogenase P40_07760 ENOG4105ENJ RND efflux system, outer membrane lipoprotein P40_07765 ENOG4105BZS acriflavin resistance protein P40_07770 ENOG4105C1P efflux transporter, rnd family, mfp subunit P40_07775 ENOG4108IG5 Transcriptional regulator P40_07780 ENOG4105CHR reductase P40_07795 ENOG4105CEY Amp-dependent synthetase and ligase P40_07800 ENOG4105C32 Amino acid ABC transporter (Permease) P40_07805 ENOG4105CF8 branched-chain amino acid ABC transporter, permease P40_07810 ENOG4105C0Z ABC transporter P40_07815 ENOG4108IV0 ABC, transporter P40_07825 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase P40_07830 ENOG4105CC9 acyl-Coa dehydrogenase P40_07835 ENOG4105C1G acyl-Coa dehydrogenase P40_07840 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein P40_07850 ENOG41084M5 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) P40_07855 ENOG4105E0K tonB-dependent siderophore receptor P40_07875 ENOG4105XMH SpoVT AbrB domain protein P40_07880 ENOG4105M0J Toxic component of a toxin-antitoxin (TA) module. A P40_07885 ENOG4105C6K Malic enzyme P40_07890 ENOG4105MP9 class II Aldolase P40_07920 ENOG4105CD5 CoA-binding domain protein P40_07925 ENOG410900P UPF0336 protein P40_07930 ENOG4105D2B acyl-CoA dehydrogenase P40_07935 ENOG4108UKI Enoyl-CoA hydratase P40_07940 ENOG4105CC9 acyl-Coa dehydrogenase P40_07945 ENOG4105KF3 Short-chain dehydrogenase reductase Sdr P40_07985 ENOG4105CHU acetyl-coa acetyltransferase P40_07990 ENOG4105K56 Transcriptional regulator P40_07995 ENOG4108ZHJ Organic hydroperoxide resistance protein P40_08025 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein P40_08035 ENOG4108MRJ P40_08040 ENOG4105DAY polysaccharide export protein P40_08050 ENOG4105D75 Capsular exopolysaccharide family P40_08060 ENOG4107UCJ Catalyzes the synthesis of activated sulfate (By similarity) P40_08095 ENOG4105DCI Phosphohydrolase P40_08105 ENOG4105CY0 Metallo-Beta-Lactamase P40_08120 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) P40_08135 ENOG4105C6Y Udp-glucose 6-dehydrogenase P40_08145 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase P40_08150 ENOG4105C6Y Udp-glucose 6-dehydrogenase P40_08170 ENOG4105D3Q Sugar transferase P40_08175 ENOG4105EXC Acyl-transferase P40_08265 ENOG4105CG6 trap dicarboxylate transporter dctm subunit P40_08275 ENOG4105RD8 TRAP dicarboxylate transporter P40_08285 ENOG4105CHU acetyl-coa acetyltransferase P40_08290 ENOG4105CEY Amp-dependent synthetase and ligase P40_08330 ENOG4105CHM Aminotransferase P40_08335 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) P40_08370 ENOG4108J1Q P40_08375 ENOG4108Y50 Glutathione-dependent formaldehyde-activating Gfa P40_08390 ENOG4105YES addiction module antidote protein P40_08395 ENOG4105VUH addiction module killer protein P40_08405 ENOG4107NPY receptor for the septal ring structure, may anchor it to the inner-membrane (By similarity) P40_08410 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) P40_08420 ENOG4105YP7 UPF0270 protein P40_08425 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) P40_08435 ENOG4108M0H Extracellular lipase P40_08445 ENOG4105BZU Histidine kinase P40_08455 ENOG4107KET secretion protein, HlyD family P40_08475 ENOG4105DA6 Catalyzes the conversion of 5-methoxyuridine (mo5U) to uridine-5-oxyacetic acid (cmo5U) at position 34 in tRNA. May also participate in the methylation of uridine-5-oxyacetic acid (cmo5U) to uridine-5-oxyacetic acid methyl ester (mcmo5U) (By similarity) P40_08480 ENOG4105PFA Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity) P40_08510 ENOG4105H9W Short-chain dehydrogenase reductase Sdr P40_08515 ENOG4105HEI LysR family (Transcriptional regulator P40_08530 ENOG4105CEY Amp-dependent synthetase and ligase P40_08535 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) P40_08545 ENOG4105E39 Enoyl-CoA hydratase P40_08550 ENOG4105C1G acyl-Coa dehydrogenase P40_08555 ENOG4107QX3 carboxylase P40_08595 ENOG4105EYW Ion transport protein P40_08600 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) P40_08610 ENOG4105CD8 aminopeptidase N P40_08615 ENOG4105D25 secreted protein P40_08620 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) P40_08630 ENOG4105WFT During stationary phase, converts 70S ribosomes to an inactive dimeric form (100S ribosomes) (By similarity) P40_08635 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) P40_08645 ENOG4105F8V Hydrolase, tatD family P40_08655 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) P40_08665 ENOG41081QV Universal stress protein P40_08670 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) P40_08685 ENOG4105U5Y Transcriptional regulator P40_08690 ENOG4108VZI ErfK ybiS ycfS ynhG family protein P40_08700 ENOG4105D64 Mechanosensitive ion channel P40_08705 ENOG4108UGV hypoxanthine phosphoribosyltransferase P40_08710 ENOG4107RHB Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates (By similarity) P40_08730 ENOG4105CPP Dehydrogenase, E1 component P40_08745 ENOG4105EQR Transposase IS116 IS110 IS902 P40_08750 ENOG4105CBX hi0933 family P40_08755 ENOG4108JA2 transcriptioN-repair coupling factor P40_08760 ENOG4105C29 acyl-CoA thioesterase P40_08770 ENOG4105DWQ NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) P40_08780 ENOG4106I92 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) P40_08790 ENOG4108IUB NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) P40_08795 ENOG4105D26 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway (By similarity) P40_08800 ENOG4105CJ2 (LipO)protein P40_08820 ENOG4108QXE glycerophosphoryl diester phosphodiesterase P40_08845 ENOG4105CC0 LysR family Transcriptional regulator P40_08870 ENOG4105DWY Agmatine deiminase P40_08885 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) P40_08890 ENOG4105C94 Transporter P40_08900 ENOG4105C7R Atpase associated with various cellular activities aaa_3 P40_08930 ENOG4105CS1 NAD(P)H quinone oxidoreductase P40_08935 ENOG4105K89 arsenate reductase P40_08940 ENOG4107S2Z UPF0761 membrane protein P40_08945 ENOG4105VSY K01512 acylphosphatase EC 3.6.1.7 P40_08985 ENOG4105CGU Enoyl-CoA hydratase P40_09000 ENOG4105C0Z ABC transporter P40_09005 ENOG4108IV0 ABC, transporter P40_09010 ENOG4105C32 Amino acid ABC transporter (Permease) P40_09025 ENOG4105VJP Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity) P40_09030 ENOG4107QMS site-determining protein P40_09035 ENOG4105K7U Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) P40_09055 ENOG4107QPN acyl-Coa dehydrogenase P40_09060 ENOG4107QR8 Thioredoxin P40_09065 ENOG4105BZU Histidine kinase P40_09070 ENOG4105CSR polyphosphate kinase 2 P40_09080 ENOG4105DVT helicase P40_09085 ENOG41072GX Peptidase M22 Glycoprotease P40_09095 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) P40_09100 ENOG4105FFN Specifically methylates the guanosine in position 1516 of 16S rRNA (By similarity) P40_09105 ENOG4105E55 glycerol-3-phosphate acyltransferase P40_09115 ENOG4108I0N Transporter, RarD family, DMT superfamily protein P40_09125 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) P40_09130 ENOG4105EJ3 Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2- amino-6-oxopimelate using succinyl-CoA (By similarity) P40_09135 ENOG4105KUZ arsenate reductase P40_09140 ENOG4105CIH Imidazole acetol-phosphate transaminase P40_09145 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) P40_09150 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) P40_09155 ENOG4105CE9 30S ribosomal protein S2 P40_09160 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) P40_09165 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) P40_09170 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) P40_09175 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) P40_09180 ENOG4105KNE Phosphatidate cytidylyltransferase P40_09185 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) P40_09190 ENOG4105DZP Membrane-associated zinc metalloprotease P40_09205 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) P40_09210 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) P40_09220 ENOG4105D0V Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) P40_09225 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) P40_09230 ENOG4105C0B DNA polymerase III (alpha subunit) P40_09235 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) P40_09240 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) P40_09245 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) P40_09250 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase P40_09255 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) P40_09260 ENOG4105XX3 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) P40_09270 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) P40_09275 ENOG4106NZV Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs (By similarity) P40_09280 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) P40_09290 ENOG4108K5P (LipO)protein P40_09320 ENOG4105CJ0 Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate (By similarity) P40_09330 ENOG4108IXY short-chain dehydrogenase reductase P40_09335 ENOG4105CB3 Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity) P40_09340 ENOG4107QP3 malate synthase g P40_09345 ENOG4105EJC lysr family transcriptional regulator P40_09350 ENOG4105F27 Major Facilitator P40_09355 ENOG4105CPC Aldo Keto reductase P40_09360 ENOG4108FN7 Aldo keto reductase P40_09385 ENOG4108JEB The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) P40_09395 ENOG4105EZE Cupin 4 family protein P40_09400 ENOG4107QTF adenylosuccinate lyase P40_09405 ENOG41075W9 High frequency lysogenization protein HflD homolog P40_09410 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) P40_09420 ENOG4108R99 pseudouridine synthase P40_09430 ENOG4105VEQ Cold shock protein P40_09435 ENOG4105KAE Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) P40_09440 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit P40_09445 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) P40_09450 ENOG4105DWA May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate P40_09455 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) P40_09465 ENOG4108R4Z Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity) P40_09470 ENOG4105C3M thioredoxin reductase P40_09475 ENOG4105CNU cell division protein FtsK P40_09480 ENOG4107Y7W Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity) P40_09485 ENOG4105D1H recombination factor protein RarA P40_09490 ENOG4108ARY Protein CrcB homolog P40_09495 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) P40_09500 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) P40_09505 ENOG4107QYG anthranilate phosphoribosyltransferase P40_09520 ENOG4108ZAT Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE (By similarity) P40_09525 ENOG4108MN8 Membrane P40_09545 ENOG4108JJA ABC, transporter P40_09555 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) P40_09590 ENOG4105CHR reductase P40_09605 ENOG4105C57 major facilitator superfamily P40_09620 ENOG4105CHR reductase P40_09645 ENOG4105C1G acyl-Coa dehydrogenase P40_09650 ENOG4108M9J MaoC like domain protein P40_09655 ENOG4108ZX5 transcriptional regulator P40_09665 ENOG4105CEY Amp-dependent synthetase and ligase P40_09680 ENOG4105C1G acyl-Coa dehydrogenase P40_09685 ENOG4105CEY Amp-dependent synthetase and ligase P40_09690 ENOG4105DRR Transcriptional regulator, GntR family P40_09700 ENOG410829K Lysine exporter protein (Lyse ygga) P40_09715 ENOG4105D22 carbon starvation protein P40_09725 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) P40_09730 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase P40_09790 ENOG4105CEY Amp-dependent synthetase and ligase P40_09795 ENOG4105CC9 acyl-Coa dehydrogenase P40_09850 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase P40_09865 ENOG4105CHR reductase P40_09875 ENOG410900P UPF0336 protein P40_09880 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) P40_09900 ENOG4107RN6 Monooxygenase P40_09920 ENOG4108ZX5 transcriptional regulator P40_09925 ENOG4107Z7P Ferredoxin P40_09955 ENOG4105DQ6 Transposase P40_09965 ENOG4105W5Q DNA repair protein (RadC P40_10080 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation P40_10255 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) P40_10345 ENOG4107QJE Chromosome Partitioning Protein P40_10355 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) P40_10360 ENOG4108IV0 ABC, transporter P40_10365 ENOG4105C0Z ABC transporter P40_10375 ENOG4105C32 Amino acid ABC transporter (Permease) P40_10380 ENOG4105CAD extracellular ligand-binding receptor P40_10415 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) P40_10420 ENOG4105J5T Amp-dependent synthetase and ligase P40_10445 ENOG4105CEY Amp-dependent synthetase and ligase P40_10470 ENOG4105EUB pirin domain protein P40_10580 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit P40_10625 ENOG4105BZU Histidine kinase P40_10630 ENOG4105BZU Histidine kinase P40_10635 ENOG4105M3Z response regulator P40_10640 ENOG4107Z5C methylesterase P40_10645 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase P40_10650 ENOG4107QHF type ii secretion system protein e P40_10655 ENOG4105D7Q type ii secretion system P40_10660 ENOG4108VAU general secretion pathway protein G P40_10665 ENOG4105VWV general secretion pathway protein h P40_10670 ENOG4105X5Z General secretion pathway protein I P40_10675 ENOG4108WWZ General secretion pathway protein J P40_10705 ENOG4105C3R Methionine synthase P40_10720 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) P40_10725 ENOG4106YVY Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) (By similarity) P40_10730 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) P40_10735 ENOG4107QY0 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) P40_10740 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) P40_10770 ENOG4107R11 Transcriptional regulator P40_10775 ENOG4105ECA phosphoserine phosphatase homoserine phosphotransferase bifunctional protein P40_10780 ENOG4105DKR Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) P40_10790 ENOG4105E09 nadh pyrophosphatase P40_10800 ENOG4105ERU peptidase P40_10820 ENOG4107QHM Sulfite reductase P40_10830 ENOG4105UQX Mate efflux family protein P40_10835 ENOG4107RUK Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins (By similarity) P40_10840 ENOG4105EQR Transposase IS116 IS110 IS902 P40_10845 ENOG4108K0D peptidase, M48 P40_10850 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) P40_10865 ENOG4105D3G Pseudouridine synthase P40_10870 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) P40_10890 ENOG4105CBM Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) P40_10920 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) P40_10925 ENOG4105W8H transhydrogenase (subunit alpha P40_10930 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) P40_10935 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) P40_10945 ENOG4105CN1 protease P40_10960 ENOG4107QUT magnesium and cobalt transport protein CorA P40_10965 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) P40_10975 ENOG4105D1Q UPF0246 protein P40_10980 ENOG4105Q9Y Universal stress protein P40_10990 ENOG4105D4P Coproporphyrinogen iii oxidase P40_11015 ENOG4105C58 cytochrome c oxidase accessory protein ccog P40_11020 ENOG4105D6P C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex (By similarity) P40_11035 ENOG4105EUH cytochrome C oxidase, cbb3-type, subunit i P40_11045 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase P40_11065 ENOG4105ETT transcriptional Regulator, LysR family P40_11070 ENOG4105CBN LysR family transcriptional regulator P40_11095 ENOG4107QX8 SPFH domain, Band 7 family protein P40_11100 ENOG4106UX7 integral membrane protein P40_11110 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit P40_11120 ENOG4105FE9 pseudouridine synthase P40_11125 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) P40_11135 ENOG4105C31 Tryptophanyl-tRNA synthetase P40_11140 ENOG4107RTD sua5 ycio yrdc ywlc family protein P40_11145 ENOG4105DB7 PHP domain protein P40_11150 ENOG4107835 probably involved in intracellular septation (By similarity) P40_11155 ENOG4105K9H YciI-like protein P40_11170 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F P40_11175 ENOG4106HNH Acyl-transferase P40_11190 ENOG4108UJV acyl-CoA thioesterase i P40_11195 ENOG4108I0Y (ABC) transporter P40_11205 ENOG4105C2C drug resistance transporter, Bcr CflA P40_11220 ENOG4108CWB sugar kinase ygcE P40_11225 ENOG4105C6V Glycerol-3-phosphate dehydrogenase P40_11230 ENOG4105CQB FAD linked oxidase domain protein P40_11235 ENOG4108ZG0 Ompa motb domain protein P40_11270 ENOG4107QJE Chromosome Partitioning Protein P40_11280 ENOG4105DC8 reductase P40_11285 ENOG4105CBC glutamate synthase P40_11290 ENOG4105E4C Lytic transglycosylase catalytic P40_11305 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) P40_11320 ENOG4105EKQ RNA-directed DNA polymerase P40_11325 ENOG4105DXD 2-methylcitrate dehydratase P40_11330 ENOG4105C7F AcnD-accessory protein PrpF P40_11335 ENOG4108I0Z Aconitate hydratase P40_11340 ENOG4105BZN citrate synthase P40_11345 ENOG4105CR4 methylisocitrate lyase P40_11350 ENOG4105DRR Transcriptional regulator, GntR family P40_11360 ENOG4105CRQ synthase (Component I) P40_11365 ENOG4107RZZ dna polymerase iii epsilon subunit P40_11370 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) P40_11380 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) P40_11385 ENOG4105E9H Lytic Murein transglycosylase P40_11390 ENOG4105E43 Extracellular solute-binding protein, family 5 P40_11395 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component P40_11400 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component P40_11405 ENOG4108JQ5 ABC transporter P40_11410 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH P40_11415 ENOG4105CGH 5'-nucleotidase P40_11420 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) P40_11430 ENOG4105K70 DNA-binding protein P40_11435 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) P40_11440 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) P40_11445 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) P40_11450 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation P40_11470 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) P40_11485 ENOG4105DSW Fusaric acid resistance protein P40_11495 ENOG4105CX6 glutaminyL-tRNA synthetase P40_11505 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) P40_11510 ENOG4105F10 Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity) P40_11515 ENOG4105FR9 TRNA-(Ms 2 io 6 A)-hydroxylase P40_11525 ENOG4108XG4 DNA-binding transcriptional regulator P40_11535 ENOG4105E5M Multidrug resistance protein D P40_11540 ENOG4107QIJ Aconitate hydratase 2 P40_11545 ENOG4105C0R drug resistance transporter emrb qaca subfamily P40_11560 ENOG4105EQ2 LysR family Transcriptional regulator P40_11570 ENOG4105CG6 trap dicarboxylate transporter dctm subunit P40_11585 ENOG4107EXU Short-chain dehydrogenase reductase Sdr P40_11590 ENOG4105CI0 Citrate lyase P40_11595 ENOG4105CI0 Citrate lyase P40_11610 ENOG4105C1G acyl-Coa dehydrogenase P40_11630 ENOG4105D2B acyl-CoA dehydrogenase P40_11635 ENOG4105D2B acyl-CoA dehydrogenase P40_11640 ENOG4108UKI Enoyl-CoA hydratase P40_11645 ENOG4105CD5 CoA-binding domain protein P40_11660 ENOG4105C0R drug resistance transporter emrb qaca subfamily P40_11685 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) P40_11715 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) P40_11745 ENOG4105CQ7 ATP-dependent helicase P40_11760 ENOG4108K3A Glutathione S-transferase P40_11765 ENOG41080UQ Transcriptional regulator P40_11785 ENOG4105CGB Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity) P40_11790 ENOG4105E0C molybdate abc transporter P40_11795 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein P40_11800 ENOG4105C72 UPF0176 protein P40_11805 ENOG4105M85 Bola protein P40_11810 ENOG4105EBR Carboxylesterase P40_11820 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) P40_11825 ENOG4105W87 Cbs domain P40_11830 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) P40_11835 ENOG4105K4T epimerase P40_11840 ENOG4105BZU Histidine kinase P40_11850 ENOG4105C1G acyl-Coa dehydrogenase P40_11855 ENOG4107QX3 carboxylase P40_11860 ENOG4106YT9 Enoyl-CoA hydratase P40_11870 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) P40_11910 ENOG4107F83 nucleotidyltransferase DNA polymerase involved in DNA P40_11920 ENOG4105C0B DNA polymerase III (alpha subunit) P40_11935 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) P40_11950 ENOG4105CHH sulfate transporter P40_11955 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) P40_11960 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) P40_11980 ENOG4105E18 UPF0276 protein P40_11990 ENOG4108R85 Short chain dehydrogenase P40_11995 ENOG4105CHR reductase P40_12000 ENOG4105C1G acyl-Coa dehydrogenase P40_12010 ENOG4105CEY Amp-dependent synthetase and ligase P40_12050 ENOG4105CQ7 ATP-dependent helicase P40_12065 ENOG4105CHQ Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity) P40_12075 ENOG4105CDV Ompa motb domain protein P40_12090 ENOG4107U7B Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) P40_12100 ENOG4105DJB Major Facilitator Superfamily P40_12105 ENOG4105KA0 thioesterase Superfamily protein P40_12125 ENOG4105R48 this blockage is overcome by subsequent expression of antitoxin HigA. Overexpression causes cleavage of a number of mRNAs in a translation-dependent fashion, suggesting this is an mRNA interferase P40_12130 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters P40_12135 ENOG4105D05 Receptor P40_12140 ENOG4105CTK cobaltochelatase, cobn subunit P40_12160 ENOG4108UYB regulatoR P40_12165 ENOG4105TX3 Histidine kinase P40_12180 ENOG4105EP1 Efflux transporter rnd family, mfp subunit P40_12185 ENOG4108IJF Heavy metal efflux pump, CzcA P40_12210 ENOG4105RWS endonuclease I P40_12215 ENOG4105DRR Transcriptional regulator, GntR family P40_12310 ENOG4108821 RND type efflux pump P40_12315 ENOG4108821 RND type efflux pump P40_12320 ENOG4105JIE May be involved in the transport of PQQ or its precursor to the periplasm (By similarity) P40_12335 ENOG4105EZY Pyrroloquinoline quinone biosynthesis protein E P40_12345 ENOG4107VK2 coenzyme PQQ biosynthesis protein PqqF P40_12360 ENOG4105HEI LysR family (Transcriptional regulator P40_12375 ENOG4105ETX regulatoR P40_12380 ENOG4105GR3 Histidine kinase P40_12415 ENOG4105CS6 Rhs element vgr protein P40_12420 ENOG41073TP transcriptional regulator P40_12425 ENOG4105DAA L-lactate P40_12430 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) P40_12440 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) P40_12465 ENOG4105YES addiction module antidote protein P40_12530 ENOG4107EXU Short-chain dehydrogenase reductase Sdr P40_12545 ENOG41082J7 Rhodanese domain protein P40_12595 ENOG4105DEN Luciferase family P40_12600 ENOG4105C1G acyl-Coa dehydrogenase P40_12605 ENOG4105CC9 acyl-Coa dehydrogenase P40_12610 ENOG4108UKI Enoyl-CoA hydratase P40_12620 ENOG4108WYP Transcriptional regulator P40_12625 ENOG4105CC9 acyl-Coa dehydrogenase P40_12630 ENOG4105C1G acyl-Coa dehydrogenase P40_12640 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F P40_12645 ENOG4108IV0 ABC, transporter P40_12650 ENOG4105C0Z ABC transporter P40_12680 ENOG41066UG Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host (By similarity) P40_12685 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) P40_12690 ENOG4107SJW iron permease, FTR1 P40_12700 ENOG4105CHM Aminotransferase P40_12710 ENOG4105D0M Protease HtpX homolog P40_12715 ENOG4105BZU Histidine kinase P40_12730 ENOG4105F8C transglutaminase domain-containing protein P40_12740 ENOG4105C7R Atpase associated with various cellular activities aaa_3 P40_12745 ENOG4105C28 cystathionine P40_12750 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase P40_12755 ENOG4105E96 Colicin v production protein P40_12765 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase P40_12770 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) P40_12775 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) P40_12780 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) P40_12785 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase P40_12790 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) P40_12800 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) P40_12805 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) P40_12810 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) P40_12815 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) P40_12820 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) P40_12825 ENOG4108MP6 LysR family Transcriptional regulator P40_12830 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase P40_12835 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) P40_12850 ENOG4105CK2 sodium dicarboxylate symporter P40_12865 ENOG4105EG6 Saccharopine dehydrogenase P40_12875 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) P40_12885 ENOG4105CGK Exodeoxyribonuclease III P40_12900 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase P40_12905 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) P40_12910 ENOG4105ECP epimerase P40_12935 ENOG4108428 Inherit from COG: -acetyltransferase P40_12940 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) P40_12950 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha P40_12955 ENOG4105CMV Succinyl-CoA synthetase subunit beta P40_12965 ENOG4105C7S Dehydrogenase P40_12970 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 P40_12975 ENOG4105E33 succinate dehydrogenase P40_12980 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) P40_12985 ENOG4105N1I succinate dehydrogenase, hydrophobic membrane anchor protein P40_12990 ENOG4108UTY succinate dehydrogenase, cytochrome b556 subunit P40_12995 ENOG4105BZN citrate synthase P40_13015 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase P40_13035 ENOG4105D5U fad dependent oxidoreductase P40_13060 ENOG4105C10 Electron transfer flavoprotein P40_13065 ENOG4105BZJ Electron transfer flavoprotein P40_13070 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase P40_13085 ENOG4105DGM nitrilase cyanide hydratase and apolipoprotein n-acyltransferase P40_13095 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) P40_13100 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) P40_13110 ENOG4105EYW Ion transport protein P40_13115 ENOG4105WZK nitrite reductase NADPH small subunit P40_13120 ENOG4107QZF nitrite reductase NADPH large subunit P40_13135 ENOG4105C3J Cysteine desulfurase P40_13150 ENOG4105CGY Dna recombination protein P40_13155 ENOG4105F8V Hydrolase, tatD family P40_13165 ENOG4107QRG dna polymerase iii P40_13170 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) P40_13175 ENOG4105HHA aminodeoxychorismate lyase P40_13180 ENOG4105YAZ 4-amino-4-deoxychorismate lyase P40_13185 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) P40_13190 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) P40_13195 ENOG4105CHR reductase P40_13200 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase P40_13205 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) P40_13210 ENOG4105VGS 50s ribosomal protein l32 P40_13220 ENOG4108UHJ MAF-like protein P40_13230 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) P40_13235 ENOG4105EI2 Pseudouridine synthase P40_13240 ENOG4105C03 ribonuclease P40_13250 ENOG4105D4A Cell wall formation (By similarity) P40_13255 ENOG4105KJF protein tyrosine phosphatase P40_13260 ENOG4105CET Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) P40_13265 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) P40_13270 ENOG4105BZ1 (ABC) transporter P40_13275 ENOG4109015 Biopolymer transport protein exbD tolR P40_13285 ENOG4108EQH DNA internalization-related competence protein ComEC Rec2 P40_13295 ENOG4108BPE -transporting atpase P40_13300 ENOG4107QI1 Mate efflux family protein P40_13345 ENOG4105EYM Major Facilitator superfamily P40_13350 ENOG4105EZ6 Catalyzes the 2'-O-methylation at nucleotide C2498 in 23S rRNA (By similarity) P40_13355 ENOG4105CIY formyltetrahydrofolate deformylase P40_13365 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) P40_13375 ENOG4105CJ1 ABC, transporter P40_13380 ENOG4107QWP ABC-2 type transporter P40_13390 ENOG4105D05 Receptor P40_13410 ENOG4105DFG type I secretion outer membrane protein P40_13415 ENOG4107QZV Type I secretion membrane fusion protein P40_13420 ENOG4108JJ6 Type I secretion system ATPase P40_13440 ENOG4105E0K tonB-dependent siderophore receptor P40_13445 ENOG4108S3W Anti-feci sigma factor, fecr P40_13450 ENOG4108SF5 RNA Polymerase P40_13455 ENOG41060WC Enoyl-CoA hydratase P40_13465 ENOG4105CC9 acyl-Coa dehydrogenase P40_13490 ENOG4105CD5 CoA-binding domain protein P40_13520 ENOG4108UWD Iron-storage protein P40_13525 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase P40_13530 ENOG4105CHU acetyl-coa acetyltransferase P40_13540 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) P40_13550 ENOG4108DG9 Smr protein MutS2 P40_13555 ENOG4105DX1 Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation (By similarity) P40_13570 ENOG4105CXB phosphoribosylaminoimidazole synthetase P40_13575 ENOG4108V3E phosphoribosylglycinamide formyltransferase P40_13590 ENOG4105DHP deoxycytidine triphosphate deaminase P40_13610 ENOG4105D3R alkyl hydroperoxide reductase P40_13650 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) P40_13665 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) P40_13670 ENOG4107SC1 transglycosylase P40_13675 ENOG4105IH7 synthase P40_13715 ENOG4105BZU Histidine kinase P40_13720 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) P40_13735 ENOG4105DGN Electron transport complex P40_13740 ENOG4108R3D Electron transport complex P40_13745 ENOG4107QTR Required for nitrogen fixation. May be part of a membrane complex functioning as an intermediate in the electron transport to nitrogenase (By similarity) P40_13750 ENOG4105D6A Electron transport complex P40_13755 ENOG4108UQQ Electron transport complex P40_13760 ENOG4105DZB Electron transport complex P40_13770 ENOG4105D6U Sodium Glutamate Symporter P40_13775 ENOG4105CSM endonuclease III P40_13780 ENOG4105KQC Competence protein P40_13785 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) P40_13790 ENOG4105CFV Tetratricopeptide repeat protein P40_13800 ENOG41080YA This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) P40_13805 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) P40_13810 ENOG4105CAT Cytidine monophosphate kinase P40_13815 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase P40_13820 ENOG4105CIH Imidazole acetol-phosphate transaminase P40_13835 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) P40_13840 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) P40_13845 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) P40_13850 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) P40_13855 ENOG4105UBK short-chain dehydrogenase reductase P40_13860 ENOG4108821 RND type efflux pump P40_13865 ENOG4108821 RND type efflux pump P40_13880 ENOG4108821 RND type efflux pump P40_13900 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) P40_13905 ENOG4105K59 histidine triad (HIT) protein P40_13915 ENOG4108ZZ3 UPF0260 protein P40_13920 ENOG4105VNG YcgL domain-containing protein P40_13925 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) P40_13930 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) P40_13940 ENOG4107IFA Lipase (EC 3.1.1.3) P40_13945 ENOG4108821 RND type efflux pump P40_13950 ENOG4105C1G acyl-Coa dehydrogenase P40_13955 ENOG4105C0A alcohol dehydrogenase P40_13960 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) P40_13965 ENOG4105KDX Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) P40_13970 ENOG4107QMP dna polymerase iii subunits gamma and tau P40_13990 ENOG4108RMJ sensory transduction regulator P40_14000 ENOG4105U3E Transcriptional regulator P40_14020 ENOG4105CYC Transferase P40_14035 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) P40_14045 ENOG4107QRP cobalamin biosynthesis protein CobW P40_14050 ENOG4105EKE dihydroorotase P40_14075 ENOG4105CG6 trap dicarboxylate transporter dctm subunit P40_14080 ENOG4105CEY Amp-dependent synthetase and ligase P40_14095 ENOG4105CSH Transporter P40_14100 ENOG4108S8N class II Aldolase P40_14105 ENOG4107F9Y LysR family transcriptional regulator P40_14110 ENOG4105CHU acetyl-coa acetyltransferase P40_14120 ENOG4105CEY Amp-dependent synthetase and ligase P40_14125 ENOG4105BZU Histidine kinase P40_14130 ENOG4108ZXC Two component transcriptional regulator, luxr family P40_14135 ENOG4105EGI Transcriptional regulator P40_14145 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) P40_14165 ENOG4105EA8 2-Nitropropane dioxygenase P40_14170 ENOG4105K78 MarR family Transcriptional regulator P40_14185 ENOG4105EQR Transposase IS116 IS110 IS902 P40_14190 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii P40_14195 ENOG4105C4M (Ubiquinol oxidase) subunit I P40_14200 ENOG4108JJ9 ABC, transporter P40_14205 ENOG4108JJ8 (ABC) transporter P40_14210 ENOG4105CFP Peptidase U32 P40_14215 ENOG4106RZ4 Peptidase U32 P40_14230 ENOG4105F1A Pyruvate formate-lyase P40_14235 ENOG4105XPQ lipid carrier protein P40_14240 ENOG4105DQQ Major facilitator superfamily MFS_1 P40_14245 ENOG4105CRU nitrate reductase, alpha subunit P40_14250 ENOG4108IUE nitrate reductase beta subunit P40_14255 ENOG4105R3A Nitrate reductase P40_14260 ENOG41076YT nitrate reductase, gamma subunit P40_14280 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) P40_14295 ENOG4105KPV Transcriptional regulator P40_14310 ENOG4105DSQ Nitric oxide reductase P40_14315 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) P40_14320 ENOG4105C8Q Methyl-accepting chemotaxis P40_14355 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) P40_14360 ENOG4105CFH Aspartokinase P40_14365 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) P40_14380 ENOG4105Y3E Modulates RecA activity (By similarity) P40_14390 ENOG4107TH8 cina domain protein P40_14400 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) P40_14455 ENOG4107ENK receptor P40_14465 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase P40_14470 ENOG4108DEF Globin P40_14490 ENOG4105CEY Amp-dependent synthetase and ligase P40_14495 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) P40_14500 ENOG4108Z4U Ferredoxin P40_14545 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein P40_14550 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family P40_14560 ENOG4105DSY exodeoxyribonuclease V, gamma P40_14565 ENOG4107QKA exodeoxyribonuclease V beta P40_14570 ENOG4107QYX exodeoxyribonuclease v alpha P40_14575 ENOG4105CDV Ompa motb domain protein P40_14580 ENOG4105WXT Conserved Protein P40_14585 ENOG410689M (LipO)protein P40_14710 ENOG4105W5Q DNA repair protein (RadC P40_14740 ENOG4105CMM transposase P40_14805 ENOG4105E3B Multicopper oxidase P40_14815 ENOG4105XJC Two component transcriptional regulator (Winged helix family P40_14820 ENOG4105BZU Histidine kinase P40_14825 ENOG4105W5Q DNA repair protein (RadC P40_14885 ENOG4105W1Y Transcriptional regulator P40_14940 ENOG4105WJX transcriptional regulator MERR family P40_14945 ENOG4108ZUF This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) P40_14950 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) P40_14955 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) P40_14960 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) P40_14965 ENOG41082NX 50s ribosomal protein l35 P40_14970 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) P40_14985 ENOG4105C6F GntR Family Transcriptional Regulator P40_14995 ENOG4105C4M (Ubiquinol oxidase) subunit I P40_15000 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii P40_15005 ENOG4105C8V SAICAR synthetase P40_15010 ENOG4105Q2H domain protein P40_15020 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) P40_15030 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen P40_15040 ENOG41082K8 Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity) P40_15045 ENOG4105ERG peptidase m48, ste24p P40_15050 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) P40_15060 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) P40_15065 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) P40_15075 ENOG4105KCK Peptidoglycan-associated lipoprotein P40_15080 ENOG4107R6Y Involved in the TonB-independent uptake of proteins (By similarity) P40_15090 ENOG4105M8F Biopolymer transport protein exbD tolR P40_15095 ENOG4105E02 MotA TolQ exbB proton channel P40_15100 ENOG4107YD3 Thioesterase P40_15105 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) P40_15110 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) P40_15115 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) P40_15120 ENOG4105CDY transcriptional regulatory protein P40_15125 ENOG4105C9M aspartyl-trna synthetase P40_15145 ENOG4108UYB regulatoR P40_15150 ENOG4105CFU surface antigen P40_15165 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) P40_15175 ENOG4107SKI cobyrinic Acid a,c-diamide synthase P40_15180 ENOG4105CSU acyl-Coa dehydrogenase P40_15185 ENOG41082JN Transcriptional regulator P40_15195 ENOG4105C9U ATP-dependent DNA helicase RecQ P40_15210 ENOG4105C1J atp-dependent rna helicase P40_15220 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) P40_15250 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) P40_15255 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) P40_15260 ENOG4105CDH Citrulline--aspartate ligase P40_15265 ENOG4105DH5 Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity) P40_15280 ENOG4105D3R alkyl hydroperoxide reductase P40_15285 ENOG4105M2J Glutaredoxin P40_15300 ENOG4105C8Y Acetylornithine aminotransferase P40_15305 ENOG4105DBV ornithine carbamoyltransferase P40_15310 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) P40_15315 ENOG4105BZU Histidine kinase P40_15320 ENOG4105BZU Histidine kinase P40_15325 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) P40_15330 ENOG4105JJR Histidine kinase P40_15335 ENOG4107EXC regulatoR P40_15340 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) P40_15345 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) P40_15355 ENOG4105C7K acetolactate synthase P40_15370 ENOG4105CKD glutathione-regulated potassium-efflux system protein P40_15390 ENOG4105CG6 trap dicarboxylate transporter dctm subunit P40_15405 ENOG4105QPS Monooxygenase P40_15425 ENOG4105C26 Dehydrogenase P40_15430 ENOG4107THI 3,4-dihydroxyphenylacetate 2,3-dioxygenase P40_15460 ENOG4108V8F Transcriptional regulator, MarR family P40_15465 ENOG4105ES9 amino acid P40_15470 ENOG4105EE5 Membrane protein terC P40_15475 ENOG4107QM5 aconitate hydratase P40_15485 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component P40_15490 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component P40_15500 ENOG4108JQ7 (ABC) transporter P40_15505 ENOG4105DEF Extracellular solute-binding protein, family 5 P40_15510 ENOG4105DUM transcriptional regulator, lysR family P40_15515 ENOG4105HMI Membrane P40_15520 ENOG4105WH1 Two component transcriptional regulator luxr family P40_15555 ENOG4105CG6 trap dicarboxylate transporter dctm subunit P40_15575 ENOG4105EBW Rhomboid-type serine protease that catalyzes intramembrane proteolysis (By similarity) P40_15585 ENOG4105FUQ Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) P40_15595 ENOG4108Z20 Acyl-transferase P40_15605 ENOG4107Z6I Thiamine biosynthesis protein P40_15620 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) P40_15630 ENOG4105CHR reductase P40_15635 ENOG4105CD3 dihydroorotase P40_15640 ENOG4105D7T ABC transporter P40_15650 ENOG4108URH decarboxylase P40_15665 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) P40_15685 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) P40_15690 ENOG4105EWT decarboxylase family P40_15710 ENOG41067HS methyltransferase P40_15735 ENOG4105D7V transposase P40_15740 ENOG4106IPI cyclase, family P40_15745 ENOG4105MYN Zinc uptake regulation protein P40_15755 ENOG4105CSU acyl-Coa dehydrogenase P40_15760 ENOG4107RSM transcriptional regulator P40_15765 ENOG4105C2C drug resistance transporter, Bcr CflA P40_15775 ENOG4108MXQ glutathione-regulated potassium-efflux system ancillary protein KefF P40_15780 ENOG4105HEI LysR family (Transcriptional regulator P40_15815 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) P40_15820 ENOG4105CHU acetyl-coa acetyltransferase P40_15825 ENOG4107RX2 synthase P40_15830 ENOG4105DZG Dehydrogenase P40_15850 ENOG4108URH decarboxylase P40_15855 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters P40_15865 ENOG4105CEY Amp-dependent synthetase and ligase P40_15870 ENOG4107RET Isocitrate lyase P40_15880 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) P40_15885 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) P40_15900 ENOG4105FZW flagellar biosynthesis regulator FlhF P40_15905 ENOG4105D7B Flagellar biosynthesis protein flha P40_15910 ENOG4105D00 flagellar biosynthetic protein flhB P40_15920 ENOG4108VYJ response regulator receiver protein P40_15925 ENOG4105C8Q Methyl-accepting chemotaxis P40_15930 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) P40_15935 ENOG4105BZU Histidine kinase P40_15940 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor P40_15945 ENOG4105C8Q Methyl-accepting chemotaxis P40_15950 ENOG4108V3W Chemotaxis protein, CheW P40_15960 ENOG4105ER2 Ompa motb domain protein P40_15965 ENOG4107RD7 Flagellar Motor Protein, MotA P40_15970 ENOG4106CIA Functions in complex with FlhD as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region P40_15975 ENOG4105GEH Functions in complex with FlhC as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region. Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes. Also regulates genes whose products function in a variety of physiological pathways (By similarity) P40_15980 ENOG4105VM1 flagellar P40_15995 ENOG4105MQ3 flagellar protein FliS P40_16000 ENOG4105DTS flagellar hook-associated P40_16005 ENOG4105I03 Flagellin P40_16015 ENOG4105ETT transcriptional Regulator, LysR family P40_16025 ENOG4105VQ0 flagellar hook-basal body complex protein fliE P40_16030 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) P40_16035 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) P40_16040 ENOG41090PJ Flagellar assembly protein P40_16045 ENOG4108JIR Flagellum-specific ATP synthase P40_16060 ENOG4107ZI8 flagellar basal body-associated protein flil P40_16065 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) P40_16070 ENOG4105DD5 Flagellar motor switch protein P40_16080 ENOG4105CN7 Flagellar biosynthetic protein FliP P40_16085 ENOG4105VS8 Flagellar biosynthetic protein fliq P40_16090 ENOG4105D19 Role in flagellar biosynthesis (By similarity) P40_16095 ENOG4105DTJ flagellar hook-associated protein P40_16100 ENOG4105E1Q flagellar hook-associated protein P40_16105 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj P40_16110 ENOG4105D92 Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) P40_16120 ENOG4105CGA flagellar basal-body rod protein FlgG P40_16125 ENOG4108KPB Flagellar basal-body rod protein FlgF P40_16130 ENOG4105BZE flagellar hook protein, FlgE P40_16135 ENOG4105W00 Flagellar hook capping protein P40_16140 ENOG4108ZC9 flagellar basal-body rod protein flgc P40_16145 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) P40_16165 ENOG4105D58 Diguanylate phosphodiesterase P40_16190 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) P40_16210 ENOG41061MV Arylsulfatase P40_16220 ENOG4105BZU Histidine kinase P40_16225 ENOG4105EEX Two component transcriptional regulator (Winged helix family P40_16245 ENOG4105CEY Amp-dependent synthetase and ligase P40_16250 ENOG4105EJC lysr family transcriptional regulator P40_16255 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) P40_16260 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) P40_16270 ENOG4105EYM Major Facilitator superfamily P40_16275 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) P40_16280 ENOG4108WBT adenosyltransferase P40_16285 ENOG4105EB3 Histidine kinase P40_16290 ENOG4105E3W Two component transcriptional regulator (Winged helix family P40_16300 ENOG4107QSN dihydrolipoamide acetyltransferase P40_16305 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) P40_16325 ENOG4105BZG amino acid carrier protein P40_16330 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase P40_16365 ENOG4107QHF type ii secretion system protein e P40_16380 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) P40_16385 ENOG41067SF Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase (By similarity) P40_16395 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) P40_16400 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving P40_16405 ENOG4105DR5 peptidase P40_16415 ENOG4105C7C involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) P40_16420 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) P40_16425 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) P40_16430 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) P40_16435 ENOG4105CPF Cell wall formation (By similarity) P40_16440 ENOG4105DFU Cell wall formation (By similarity) P40_16445 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) P40_16450 ENOG4105CNI cell division protein FtsW P40_16455 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) P40_16460 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) P40_16465 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) P40_16470 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) P40_16475 ENOG4105CJN penicillin-binding protein P40_16485 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) P40_16490 ENOG4108V6E Cell division protein mraZ P40_16500 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) P40_16510 ENOG41082RQ UPF0102 protein P40_16520 ENOG4105W4M Transport-associated protein P40_16525 ENOG4105CEY Amp-dependent synthetase and ligase P40_16530 ENOG41061TZ Short-chain dehydrogenase reductase Sdr P40_16540 ENOG4105CBG Sulfatase P40_16545 ENOG4105KB2 stringent starvation protein b P40_16550 ENOG4107MKT Stringent starvation protein a P40_16555 ENOG4105EIX cytochrome c1 P40_16560 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) P40_16565 ENOG4108R5F Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) P40_16570 ENOG4108UJD 30S ribosomal protein S9 P40_16575 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) P40_16580 ENOG4105CPC Aldo Keto reductase P40_16600 ENOG4105DRR Transcriptional regulator, GntR family P40_16610 ENOG4105C32 Amino acid ABC transporter (Permease) P40_16620 ENOG4105C0Z ABC transporter P40_16625 ENOG4108IV0 ABC, transporter P40_16635 ENOG4105C1G acyl-Coa dehydrogenase P40_16670 ENOG4108J1Q P40_16695 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation P40_16700 ENOG4105C1G acyl-Coa dehydrogenase P40_16705 ENOG4105D6Z AFG1 family ATPase P40_16710 ENOG4105DHZ alpha beta P40_16720 ENOG4107RIQ Sulfate adenylate transferase P40_16725 ENOG4105CBD Diacylglycerol kinase P40_16730 ENOG4107QNR UPF0135 protein P40_16735 ENOG4105C0H protease P40_16745 ENOG4105CIH Imidazole acetol-phosphate transaminase P40_16750 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) P40_16755 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) P40_16760 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) P40_16765 ENOG4105VFK BolA family P40_16780 ENOG4105C2X Arabinose 5-phosphate isomerase P40_16785 ENOG4108Z4R 3-deoxy-d-manno-octulosonate 8-phosphate phosphatase P40_16800 ENOG4108IUZ ABC transporter P40_16805 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) P40_16810 ENOG41080QH sigma 54 modulation protein ribosomal protein S30EA P40_16815 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN P40_16820 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) P40_16835 ENOG4105F7F Chaperone P40_16845 ENOG4105CMS peptidase U62, modulator of DNA gyrase P40_16850 ENOG4105N42 UPF0307 protein P40_16855 ENOG4105DJ2 Major Facilitator Superfamily P40_16860 ENOG410870F Cyclic nucleotide-binding protein P40_16865 ENOG4105D1U peptidase U62 modulator of DNA gyrase P40_16880 ENOG4108Z03 MAF-like protein P40_16885 ENOG4105VQ7 Rod shape-determining protein MreD P40_16890 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) P40_16895 ENOG4105DFF Rod shape-determining protein mreb P40_16900 ENOG41080G2 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) P40_16905 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) P40_16910 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) P40_16925 ENOG4105E39 Enoyl-CoA hydratase P40_17005 ENOG4105CPW cytochrome b561 P40_17020 ENOG4105BZU Histidine kinase P40_17025 ENOG4105WH1 Two component transcriptional regulator luxr family P40_17040 ENOG4105D06 uba thif-type nad fad binding protein P40_17045 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) P40_17050 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) P40_17055 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) P40_17065 ENOG4105C1U Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein (By similarity) P40_17070 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) P40_17080 ENOG4105C5T Phosphoribosyl pyrophosphate synthase P40_17085 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) P40_17090 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) P40_17100 ENOG4105C3G gtp-binding protein P40_17110 ENOG4107XAN XdhC and CoxI family P40_17185 ENOG4105C09 Bile acid P40_17190 ENOG4105D7W serine acetyltransferase P40_17195 ENOG4105CVS RNA methyltransferase TrmH family, group 1 P40_17200 ENOG4105ECY inositol monophosphatase P40_17205 ENOG4105C26 Dehydrogenase P40_17210 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) P40_17215 ENOG4108JPW Aminotransferase P40_17225 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) P40_17230 ENOG4105CHM Aminotransferase P40_17235 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) P40_17240 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) P40_17245 ENOG4105VIE preprotein translocase, subunit YajC P40_17250 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) P40_17255 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) P40_17280 ENOG41089N3 Inherit from COG: cobyrinic Acid a,c-diamide synthase P40_17550 ENOG4105KRQ Addiction module toxin, Txe YoeB family P40_17555 ENOG4105VTW prevent-host-death family P40_17570 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) P40_17645 ENOG4105W5Q DNA repair protein (RadC P40_17690 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) P40_17700 ENOG4108K5H permease YjgP YjgQ family protein P40_17705 ENOG4108M8S permease YjgP YjgQ family protein P40_17710 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) P40_17715 ENOG4105MYG DNA polymerase iii, chi subunit P40_17720 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) P40_17735 ENOG4107TE5 Lipid kinase P40_17765 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase P40_17770 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase P40_17775 ENOG4105EMY transcriptional regulator P40_17785 ENOG4105CEY Amp-dependent synthetase and ligase P40_17800 ENOG4108ZP8 Acetolactate synthase small subunit P40_17805 ENOG4105C7K acetolactate synthase P40_17820 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit P40_17825 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase P40_17830 ENOG4105C34 Pseudouridine synthase P40_17835 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane P40_17850 ENOG4107TUY Histidine kinase P40_17855 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family P40_17860 ENOG4105MWK D-amino acid dehydrogenase, small subunit P40_17900 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) P40_17905 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase P40_17910 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) P40_17915 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) P40_17920 ENOG4105DTN riboflavin biosynthesis protein ribF P40_17925 ENOG4105CJR Integral membrane protein (MviN P40_17930 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) P40_17935 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) P40_17940 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control P40_17945 ENOG4105K46 50S ribosomal protein l27 P40_17950 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) P40_17955 ENOG4105EAH synthase P40_17985 ENOG4108ZX5 transcriptional regulator P40_17990 ENOG41061TZ Short-chain dehydrogenase reductase Sdr P40_18025 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) P40_18035 ENOG4105EJ2 Transcriptional regulator P40_18040 ENOG4105PDP Short chain dehydrogenase P40_18045 ENOG4105D74 hydrolase P40_18050 ENOG4105F8J Adenylate Guanylate cyclase P40_18060 ENOG4105GVR general secretion pathway protein D P40_18075 ENOG4108UUM single-stranded DNA-binding protein P40_18080 ENOG4107RDB Major Facilitator P40_18085 ENOG41086KC Transcriptional regulator P40_18090 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) P40_18115 ENOG4105CHH sulfate transporter P40_18125 ENOG4108ZT0 50S ribosomal protein l17 P40_18130 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) P40_18135 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) P40_18140 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) P40_18145 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits P40_18150 ENOG41067V7 50S ribosomal protein L36 P40_18155 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) P40_18160 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) P40_18165 ENOG4105VPB 50S ribosomal protein L30 P40_18170 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) P40_18175 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) P40_18180 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) P40_18185 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) P40_18190 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) P40_18195 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits P40_18200 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) P40_18205 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) P40_18210 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal P40_18215 ENOG41083MP 50s ribosomal protein l29 P40_18220 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) P40_18225 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) P40_18230 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) P40_18235 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) P40_18240 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity P40_18245 ENOG41080KG One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) P40_18250 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) P40_18255 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) P40_18260 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) P40_18265 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) P40_18270 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) P40_18275 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) P40_18280 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) P40_18285 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) P40_18290 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) P40_18295 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) P40_18300 ENOG4108VZM 50s ribosomal protein L10 P40_18305 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) P40_18310 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) P40_18315 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) P40_18320 ENOG4105PM1 preprotein translocase subunit SecE P40_18330 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) P40_18360 ENOG4108194 Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) P40_18365 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase P40_18400 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) P40_18405 ENOG4105DR5 peptidase P40_18410 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) P40_18420 ENOG4108YX9 iron--sulfur cluster insertion protein erpA P40_18435 ENOG4105CMQ Chloride channel P40_18440 ENOG4108YXA Membrane P40_18445 ENOG4105DWF phosphomethylpyrimidine kinase P40_18450 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) P40_18455 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase P40_18460 ENOG4108Z66 YbaK ebsC protein P40_18470 ENOG4105BZ4 penicillin-binding protein P40_18485 ENOG4105E27 serine threonine protein kinase P40_18490 ENOG4105PW4 Sugar fermentation stimulation protein homolog P40_18495 ENOG4105CHM Aminotransferase P40_18505 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters P40_18510 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) P40_18530 ENOG4105DJ0 Poly(A) Polymerase P40_18535 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase P40_18545 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) P40_18550 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) P40_18555 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) P40_18560 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) P40_18570 ENOG4105C0R drug resistance transporter emrb qaca subfamily P40_18590 ENOG4105E39 Enoyl-CoA hydratase P40_18615 ENOG4105CG6 trap dicarboxylate transporter dctm subunit P40_18625 ENOG41073TP transcriptional regulator P40_18640 ENOG4105EKQ RNA-directed DNA polymerase P40_18645 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) P40_18650 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) P40_18660 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) P40_18665 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) P40_18670 ENOG4105CHV Transcription elongation factor NusA P40_18675 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) P40_18690 ENOG4107EJC Preprotein translocase subunit SecG P40_18695 ENOG4105CP7 Triose-phosphate isomerase P40_18700 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) P40_18705 ENOG4105EEI dihydropteroate synthase P40_18710 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) P40_18715 ENOG4105F7M Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity) P40_18720 ENOG4105HBR Rna-binding protein P40_18725 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) P40_18730 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain P40_18735 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain P40_18740 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) P40_18745 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) P40_18750 ENOG4105CFG Acts as a chaperone (By similarity) P40_18755 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ P40_18760 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) P40_18765 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) P40_18770 ENOG41090R7 Ferric uptake P40_18775 ENOG4105YRI Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) P40_18780 ENOG4105VDB UPF0125 protein P40_18785 ENOG4105C8J )-transporter P40_18790 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) P40_18845 ENOG4107SCA Formamidase (EC 3.5.1.49) P40_18850 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component P40_18880 ENOG4105C26 Dehydrogenase P40_18895 ENOG4107SET aldo keto reductase P40_18900 ENOG4105EWI Short-chain dehydrogenase reductase Sdr P40_18905 ENOG4105EJC lysr family transcriptional regulator P40_18930 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) P40_18960 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component P40_18995 ENOG4105DJ2 Major Facilitator Superfamily P40_19010 ENOG4107XKF NMT1 THI5 Like Domain Protein P40_19015 ENOG4107XKF NMT1 THI5 Like Domain Protein P40_19020 ENOG4105CS1 NAD(P)H quinone oxidoreductase P40_19025 ENOG4107QUY Guanine deaminase P40_19030 ENOG4105FFA Catalyzes the oxidation of uric acid to 5- hydroxyisourate, which is further processed to form (S)-allantoin (By similarity) P40_19040 ENOG4105VT2 5-hydroxyisourate hydrolase P40_19050 ENOG4105DHG Allantoate amidinohydrolase P40_19055 ENOG4108Z2U ureidoglycolate hydrolase P40_19065 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) P40_19070 ENOG4107V2S Transcriptional regulator P40_19095 ENOG4105Y36 Binding-protein-dependent transport systems, inner membrane component P40_19100 ENOG4108FWV Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) P40_19120 ENOG4108VKV Monofunctional biosynthetic peptidoglycan transglycosylase P40_19130 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain P40_19140 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) P40_19145 ENOG4108ZRZ Transcriptional regulator (AsnC family) P40_19150 ENOG4107QWB Ornithine cyclodeaminase P40_19160 ENOG4105C26 Dehydrogenase P40_19175 ENOG4105C1G acyl-Coa dehydrogenase P40_19180 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr P40_19190 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) P40_19195 ENOG4108IV0 ABC, transporter P40_19200 ENOG4105C0Z ABC transporter P40_19210 ENOG4105C32 Amino acid ABC transporter (Permease) P40_19240 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) P40_19245 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) P40_19250 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) P40_19255 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) P40_19260 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) P40_19265 ENOG4107QP2 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) P40_19270 ENOG4108N5B 2-phosphosulfolactate phosphatase P40_19275 ENOG4105C1G acyl-Coa dehydrogenase P40_19280 ENOG41090A4 Pterin carbinolamine dehydratase P40_19290 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) P40_19295 ENOG4105BZ8 glutamate synthase P40_19300 ENOG4105CBC glutamate synthase P40_19310 ENOG4105D49 3-dehydroquinate synthase P40_19315 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) P40_19320 ENOG4105E4G Type IV pilus P40_19345 ENOG4108JQC penicillin-binding protein 1A P40_19360 ENOG4105C6K Malic enzyme P40_19365 ENOG4105VFB Binds the 23S rRNA (By similarity) P40_19370 ENOG4105C25 Primosomal protein n' P40_19380 ENOG4105CW7 secretion protein, HlyD family P40_19385 ENOG4105C75 arginyL-tRNA synthetase P40_19395 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) P40_19400 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) P40_19405 ENOG4105C01 Dihydroxy-acid dehydratase P40_19420 ENOG4108EX3 reductase P40_19425 ENOG4105F1S paraquat-inducible protein a P40_19430 ENOG4105DY2 Paraquat-inducible protein b P40_19455 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) P40_19460 ENOG4108NEV two component transcriptional regulator, LytTR family P40_19465 ENOG4108HRK Histidine kinase P40_19470 ENOG4105CH7 arginosuccinase P40_19480 ENOG4107QI1 Mate efflux family protein P40_19490 ENOG4105M0J Toxic component of a toxin-antitoxin (TA) module. A P40_19510 ENOG4108SF5 RNA Polymerase P40_19530 ENOG4108UIN ybak prolyl-trna synthetase associated region P40_19535 ENOG4105NXH GreA GreB family elongation factor P40_19540 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) P40_19545 ENOG4105D6S protein involved in catabolism of external DNA P40_19550 ENOG4108MUZ hydrolase P40_19565 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) P40_19575 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) P40_19585 ENOG4105WP7 tRNA pseudouridine synthase C P40_19590 ENOG4108556 Isoprenoid biosynthesis protein with amidotransferase-like domain P40_19600 ENOG4108RRZ Transcription elongation factor GreB P40_19605 ENOG4105D52 delta-aminolevulinic acid dehydratase P40_19610 ENOG4105E0K tonB-dependent siderophore receptor P40_19620 ENOG4105F4I Transcriptional regulator P40_19625 ENOG4105C9X ppx gppa phosphatase P40_19630 ENOG4105K63 Thioredoxin P40_19635 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) P40_19640 ENOG4105CHJ isochorismatase hydrolase P40_19645 ENOG4105EJC lysr family transcriptional regulator P40_19655 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) P40_19680 ENOG4105EB3 Histidine kinase P40_19685 ENOG4105E3W Two component transcriptional regulator (Winged helix family P40_19690 ENOG4105EG6 Saccharopine dehydrogenase P40_19695 ENOG4105GAK amidohydrolase 2 P40_19700 ENOG4105CG6 trap dicarboxylate transporter dctm subunit P40_19710 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit P40_19715 ENOG4107YCY Transcriptional regulator P40_19720 ENOG4105DV0 amidase (EC 3.5.1.4 P40_19725 ENOG4105CIS alcohol dehydrogenase P40_19730 ENOG4105CEY Amp-dependent synthetase and ligase P40_19745 ENOG4107T32 3-phytase (EC 3.1.3.8) P40_19760 ENOG4108ZX5 transcriptional regulator P40_19770 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase P40_19775 ENOG410904A RNA polymerase P40_19805 ENOG4105VRT cytoplasmic protein P40_19815 ENOG4105PGM cation diffusion facilitator family transporter P40_19820 ENOG4105W1Y Transcriptional regulator P40_19825 ENOG4105DN9 Na H antiporter P40_19830 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b P40_19840 ENOG4105CNG UPF0061 protein P40_19860 ENOG4105C1P efflux transporter, rnd family, mfp subunit P40_19885 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) P40_19925 ENOG4105EQR Transposase IS116 IS110 IS902 P40_19930 ENOG4108JU3 Alkyl hydroperoxide reductase P40_19935 ENOG4105D3R alkyl hydroperoxide reductase P40_19940 ENOG4108IJ6 ABC transporter P40_19945 ENOG4105ECW sulfate abc transporter P40_19950 ENOG4108I5D sulfate abc transporter P40_19955 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein P40_19960 ENOG4108Z9W Outer membrane porin P40_19975 ENOG4105C8Q Methyl-accepting chemotaxis P40_19985 ENOG4105E3B Multicopper oxidase P40_20000 ENOG41077A9 carbonic anhydrase P40_20005 ENOG4108YZY peptidylprolyl cis-trans isomerase P40_20040 ENOG4105CEY Amp-dependent synthetase and ligase P40_20050 ENOG4105C26 Dehydrogenase P40_20055 ENOG4105CSU acyl-Coa dehydrogenase P40_20060 ENOG4105CHR reductase P40_20070 ENOG4108Z7G MaoC domain protein dehydratase P40_20080 ENOG4105BZU Histidine kinase P40_20085 ENOG4108ZXC Two component transcriptional regulator, luxr family P40_20095 ENOG4105DC8 reductase P40_20100 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family P40_20110 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) P40_20115 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase P40_20120 ENOG4105C0Y Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) P40_20125 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) P40_20130 ENOG4108ESU Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Involved in the translocation of the substrate across the membrane (By similarity) P40_20135 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) P40_20140 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) P40_20145 ENOG4105EFT decarboxylase P40_20150 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) P40_20155 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) P40_20165 ENOG4105GN9 Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) P40_20180 ENOG4105DHQ Histidine kinase P40_20200 ENOG4105MPD Cytochrome P40_20205 ENOG4108YZT Adenosylcobinamide kinase P40_20220 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F P40_20225 ENOG41061TZ Short-chain dehydrogenase reductase Sdr P40_20230 ENOG4105C5X domain protein P40_20240 ENOG4108Q67 UPF0319 protein P40_20250 ENOG4105KF3 Short-chain dehydrogenase reductase Sdr P40_20255 ENOG4107RSM transcriptional regulator P40_20260 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme P40_20265 ENOG4105C5I Dehydrogenase P40_20275 ENOG4105C26 Dehydrogenase P40_20280 ENOG4105CZ6 Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine (By similarity) P40_20285 ENOG4105C94 Transporter P40_20295 ENOG4105DP5 Catalyzes the biosynthesis of agmatine from arginine (By similarity) P40_20300 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) P40_20305 ENOG4105C2C drug resistance transporter, Bcr CflA P40_20315 ENOG4105PDP Short chain dehydrogenase P40_20320 ENOG4107YPT transcriptional regulator P40_20350 ENOG4105W0Z cytoplasmic protein P40_20355 ENOG4105EUZ Beta-lactamase domain protein P40_20365 ENOG4105C0P Mg chelatase subunit ChlI P40_20370 ENOG410631K Membrane P40_20380 ENOG4105C2D reductase P40_20385 ENOG4108ZX5 transcriptional regulator P40_20390 ENOG4105I08 Pseudouridine synthase P40_20395 ENOG4105C4R Atp-dependent dna helicase P40_20400 ENOG4105MPD Cytochrome P40_20405 ENOG4105ES5 Histidine kinase P40_20415 ENOG4105CK6 Two component transcriptional regulator (Winged helix family P40_20435 ENOG4105C1G acyl-Coa dehydrogenase P40_20440 ENOG4105CC9 acyl-Coa dehydrogenase P40_20455 ENOG4105CEY Amp-dependent synthetase and ligase P40_20460 ENOG4105CEY Amp-dependent synthetase and ligase P40_20465 ENOG4105CG6 trap dicarboxylate transporter dctm subunit P40_20475 ENOG4105CEY Amp-dependent synthetase and ligase P40_20480 ENOG4105F2C Acetyl-CoA acetyltransferase P40_20490 ENOG41061ZR Transcriptional regulator P40_20500 ENOG4105E39 Enoyl-CoA hydratase P40_20505 ENOG4105H9W Short-chain dehydrogenase reductase Sdr P40_20515 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F P40_20525 ENOG4108UKI Enoyl-CoA hydratase P40_20530 ENOG4105C1G acyl-Coa dehydrogenase P40_20545 ENOG4105CGU Enoyl-CoA hydratase P40_20550 ENOG4105CHR reductase P40_20565 ENOG4105EW9 transcriptional regulator AsnC family P40_20570 ENOG4108NIW Leucine export protein LeuE P40_20580 ENOG4105CG6 trap dicarboxylate transporter dctm subunit P40_20615 ENOG4105Y7X Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity) P40_20655 ENOG4105Y49 secretion protein, HlyD family P40_20670 ENOG4108YYC ycei family P40_20675 ENOG4105DS1 cytochrome b561 P40_20685 ENOG4108R85 Short chain dehydrogenase P40_20690 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase P40_20695 ENOG4105C09 Bile acid P40_20700 ENOG4105CAY ferredoxin--nadp reductase P40_20715 ENOG4108UKI Enoyl-CoA hydratase P40_20730 ENOG4108IJ8 ABC transporter P40_20760 ENOG4105EHV domain protein P40_20765 ENOG4105ENJ RND efflux system, outer membrane lipoprotein P40_20775 ENOG4105BZS acriflavin resistance protein P40_20785 ENOG4105CH6 catalase P40_20790 ENOG4108UT2 hemolysin iii P40_20795 ENOG4105E0K tonB-dependent siderophore receptor P40_20815 ENOG4105W2Z cytochrome C, class I P40_20830 ENOG4108T0W nitrous oxide maturation protein NosY P40_20835 ENOG4105CIG ABC transporter P40_20845 ENOG4105EQJ Nitrous-oxide reductase is part of a bacterial respiratory system which is activated under anaerobic conditions in the presence of nitrate or nitrous oxide (By similarity) P40_20850 ENOG4105HEE Binding Domain protein P40_20865 ENOG4106RE7 Cytochrome P40_20875 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) P40_20880 ENOG4105KJM monovalent cation h antiporter subunit g P40_20885 ENOG4105W4C monovalent cation H antiporter subunit F P40_20890 ENOG4105SC1 monovalent cation H antiporter subunit E P40_20895 ENOG4107R4Z monovalent cation h antiporter subunit d P40_20900 ENOG4108ZE9 Monovalent cation H antiporter subunit C P40_20905 ENOG4105D65 subunit l P40_20920 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) P40_20925 ENOG41063TF transcriptional regulator (AraC P40_20930 ENOG4105CY2 Citrate transporter P40_20935 ENOG4105C26 Dehydrogenase P40_20940 ENOG4105C1G acyl-Coa dehydrogenase P40_20945 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase P40_20950 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase P40_20965 ENOG4105EV8 ectoine hydroxylase P40_20970 ENOG4105CHR reductase P40_20975 ENOG4108KSA LysR family transcriptional regulator P40_20980 ENOG4105CG6 trap dicarboxylate transporter dctm subunit P40_21010 ENOG4108Z4X TRANSCRIPTIONal P40_21015 ENOG4105DA5 (ABC) transporter P40_21020 ENOG4105E3A (ABC) transporter P40_21040 ENOG4108TGY Glutathione S-transferase P40_21065 ENOG4108VPT UPF0234 protein P40_21075 ENOG41082AG Plasmid maintenance system antidote protein P40_21085 ENOG4105C2M dna polymerase I P40_21110 ENOG4105FDK ABC transporter P40_21115 ENOG4105FAV ABC, transporter P40_21120 ENOG4107R73 Mate efflux family protein P40_21175 ENOG4107QZF nitrite reductase NADPH large subunit P40_21180 ENOG4105VCQ rubredoxin P40_21185 ENOG4105VEI Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4- hydroxybenzoate (4HB) for the ubiquinone pathway (By similarity) P40_21190 ENOG4105C4G Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity) P40_21195 ENOG4105CK6 Two component transcriptional regulator (Winged helix family P40_21200 ENOG4105BZU Histidine kinase P40_21205 ENOG41069P5 Protein slyX homolog P40_21225 ENOG4108VWS Yaeq family P40_21235 ENOG4105CAU Arsenical resistance protein, ArsH P40_21240 ENOG4107R5R arsenical pump membrane protein P40_21245 ENOG4108UXE Protein tyrosine phosphatase P40_21250 ENOG41082YX Transcriptional regulator, arsr family P40_21255 ENOG4108UTW Plays a role in the regulation of phosphate uptake P40_21260 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) P40_21265 ENOG4105E2Z phosphate ABC transporter (Permease P40_21270 ENOG4105C8U phosphate abc transporter P40_21275 ENOG4105CVA phosphate P40_21285 ENOG4105CG6 trap dicarboxylate transporter dctm subunit P40_21290 ENOG4105NAU thioesterase Superfamily protein P40_21295 ENOG4105CH5 extracellular solute-binding protein, family 7 P40_21300 ENOG4105C4R Atp-dependent dna helicase P40_21305 ENOG4105BZU Histidine kinase P40_21320 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family P40_21330 ENOG4105DZG Dehydrogenase P40_21335 ENOG4105C26 Dehydrogenase P40_21370 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component P40_21375 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component P40_21380 ENOG4105DEF Extracellular solute-binding protein, family 5 P40_21395 ENOG4105CSU acyl-Coa dehydrogenase P40_21400 ENOG4108SGK Tetr family transcriptional regulator P40_21425 ENOG4107YD3 Thioesterase P40_21430 ENOG4105CEY Amp-dependent synthetase and ligase P40_21435 ENOG4107RZC phospholipase d P40_21440 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) P40_21445 ENOG4105E0X reductase P40_21450 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic P40_21460 ENOG4105ETT transcriptional Regulator, LysR family P40_21475 ENOG4105CD3 dihydroorotase P40_21485 ENOG4105C32 Amino acid ABC transporter (Permease) P40_21490 ENOG4105C32 Amino acid ABC transporter (Permease) P40_21495 ENOG4105C0Z ABC transporter P40_21500 ENOG4108IV0 ABC, transporter P40_21525 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) P40_21530 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) P40_21535 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) P40_21540 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) P40_21545 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) P40_21550 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) P40_21555 ENOG4107S15 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) P40_21560 ENOG4107Z6K F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) P40_21565 ENOG4105KY6 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) P40_21570 ENOG4105EE4 it plays a direct role in the translocation of protons across the membrane (By similarity) P40_21580 ENOG4105FA0 parb-like partition protein P40_21585 ENOG4107QJE Chromosome Partitioning Protein P40_21590 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) P40_21595 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) P40_21600 ENOG4105C3N Participates in control of cell volume in low-osmolarity conditions (By similarity) P40_21605 ENOG4108IXY short-chain dehydrogenase reductase P40_21615 ENOG4105CSU acyl-Coa dehydrogenase P40_21620 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) P40_21630 ENOG4105D8T Acyltransferase P40_21635 ENOG4105VEQ Cold shock protein P40_21645 ENOG4105D82 Glutamate dehydrogenase P40_21655 ENOG4105BZS acriflavin resistance protein P40_21660 ENOG4105ENT Efflux transporter rnd family, mfp subunit P40_21665 ENOG4105CEY Amp-dependent synthetase and ligase P40_21670 ENOG4105C9Q fumarate hydratase class II P40_21685 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) P40_21690 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins P40_21695 ENOG4105NVJ RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) P40_21700 ENOG4105VG0 50S ribosomal protein l34