locus-tag	class	description
P40_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
P40_00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
P40_00020	COG0187	DNA topoisomerase II activity
P40_00035	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
P40_00055	COG0683	leucine binding
P40_00070	COG0751	glycine-tRNA ligase activity
P40_00080	COG2818	Glycosylase
P40_00085	COG0519	Catalyzes the synthesis of GMP from XMP
P40_00085	COG0518	GMP synthase (glutamine-hydrolyzing) activity
P40_00110	COG0189	ligase activity
P40_00110	COG4067	protein conserved in archaea
P40_00115	COG0179	Fumarylacetoacetate (FAA) hydrolase
P40_00120	COG0277	FAD linked oxidase domain protein
P40_00125	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
P40_00170	COG0405	Gamma-glutamyltransferase
P40_00190	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
P40_00210	COG1414	Transcriptional regulator
P40_00230	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
P40_00240	COG0429	hydrolase of the alpha beta-hydrolase fold
P40_00245	COG0330	HflC and HflK could
P40_00255	COG1385	rRNA (uridine-N3-)-methyltransferase activity
P40_00260	COG0154	amidase activity
P40_00265	COG0640	Transcriptional regulator
P40_00280	COG2814	Major facilitator Superfamily
P40_00295	COG0433	COG0433 Predicted ATPase
P40_00300	COG1047	Peptidyl-prolyl cis-trans
P40_00320	COG2201	protein-glutamate methylesterase activity
P40_00335	COG0840	transmembrane signaling receptor activity
P40_00355	COG0189	ligase activity
P40_00365	COG1678	Uncharacterized ACR, COG1678
P40_00370	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
P40_00380	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
P40_00385	COG0540	Belongs to the ATCase OTCase family
P40_00400	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
P40_00405	COG0745	RESPONSE REGULATOR receiver
P40_00410	COG0642	Histidine kinase
P40_00425	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
P40_00430	COG0435	Glutathione S-transferase
P40_00470	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
P40_00500	COG1960	acyl-CoA dehydrogenase activity
P40_00520	COG3239	Fatty acid desaturase
P40_00535	COG0415	Belongs to the DNA photolyase family
P40_00575	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
P40_00580	COG0642	Histidine kinase
P40_00600	COG1024	Enoyl-CoA hydratase
P40_00605	COG1960	acyl-CoA dehydrogenase activity
P40_00615	COG0183	Belongs to the thiolase family
P40_00625	COG3618	amidohydrolase
P40_00630	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
P40_00635	COG0569	domain protein
P40_00645	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
P40_00650	COG0242	peptide deformylase activity
P40_00660	COG0758	DNA mediated transformation
P40_00665	COG0009	L-threonylcarbamoyladenylate synthase
P40_00670	COG0408	coproporphyrinogen oxidase activity
P40_00675	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
P40_00685	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
P40_00690	COG0339	signal peptide processing
P40_00755	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
P40_00760	COG0583	DNA-binding transcription factor activity
P40_00770	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
P40_00775	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
P40_00780	COG2272	Belongs to the type-B carboxylesterase lipase family
P40_00810	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
P40_00815	COG1758	RNA polymerase activity
P40_00820	COG0194	GDP metabolic process
P40_00825	COG3608	succinylglutamate desuccinylase aspartoacylase
P40_00840	COG1804	L-carnitine dehydratase bile acid-inducible protein F
P40_00845	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
P40_00885	COG1561	YicC-like family, N-terminal region
P40_00890	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
P40_00895	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
P40_00905	COG1309	transcriptional regulator
P40_00910	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
P40_00920	COG0756	dUTP diphosphatase activity
P40_00925	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
P40_00930	COG2003	Belongs to the UPF0758 family
P40_00935	COG0227	Belongs to the bacterial ribosomal protein bL28 family
P40_00940	COG0267	Belongs to the bacterial ribosomal protein bL33 family
P40_00965	COG4964	Belongs to the GSP D family
P40_01010	COG1414	Transcriptional regulator
P40_01020	COG1804	L-carnitine dehydratase bile acid-inducible protein F
P40_01065	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
P40_01085	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
P40_01090	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
P40_01095	COG0635	Involved in the biosynthesis of porphyrin-containing compound
P40_01105	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
P40_01105	COG2813	Specifically methylates the guanine in position
P40_01110	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
P40_01125	COG0220	tRNA (guanine-N7-)-methyltransferase activity
P40_01130	COG2022	thiamine diphosphate biosynthetic process
P40_01140	COG2363	Small membrane protein
P40_01150	COG2177	Part of the ABC transporter FtsEX involved in
P40_01155	COG2884	Cell division ATP-binding protein ftsE
P40_01160	COG0552	protein localization to endoplasmic reticulum
P40_01165	COG0612	Peptidase, M16
P40_01175	COG0742	ribosomal rna small subunit methyltransferase
P40_01195	COG3123	guanosine phosphorylase activity
P40_01205	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
P40_01210	COG0402	S-adenosylhomocysteine deaminase activity
P40_01215	COG0534	Mate efflux family protein
P40_01220	COG1473	amidohydrolase
P40_01235	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
P40_01250	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
P40_01260	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
P40_01265	COG0640	Transcriptional regulator
P40_01275	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
P40_01280	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
P40_01285	COG0126	phosphoglycerate kinase activity
P40_01320	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
P40_01335	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
P40_01340	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
P40_01355	COG3079	Belongs to the UPF0149 family
P40_01360	COG0006	proline dipeptidase activity
P40_01365	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
P40_01370	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
P40_01380	COG1178	ABC-type Fe3 transport system permease component
P40_01395	COG0404	The glycine cleavage system catalyzes the degradation of glycine
P40_01400	COG0509	glycine decarboxylation via glycine cleavage system
P40_01405	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
P40_01410	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
P40_01460	COG1063	alcohol dehydrogenase
P40_01465	COG1942	4-Oxalocrotonate Tautomerase
P40_01490	COG3609	addiction module antidote protein, CC2985 family
P40_01510	COG0346	lactoylglutathione lyase activity
P40_01545	COG1944	ATP diphosphatase activity
P40_01565	COG0625	glutathione transferase activity
P40_01575	COG0604	alcohol dehydrogenase
P40_01575	COG1028	Short-chain dehydrogenase reductase Sdr
P40_01575	COG3321	synthase
P40_01590	COG2226	methyltransferase
P40_01625	COG0456	acetyltransferase
P40_01630	COG0625	glutathione transferase activity
P40_01705	COG1960	acyl-CoA dehydrogenase activity
P40_01715	COG1652	LysM domain
P40_01715	COG2823	Periplasmic or secreted lipoprotein
P40_01735	COG3738	Protein conserved in bacteria
P40_01745	COG0625	glutathione transferase activity
P40_01775	COG0431	NADPH-dependent FMN reductase
P40_01785	COG0596	Alpha beta hydrolase
P40_01790	COG2824	Alkylphosphonate utilization operon protein PhnA
P40_01795	COG2031	fatty acid transporter
P40_01805	COG0656	L-ascorbic acid biosynthetic process
P40_01810	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
P40_01815	COG1690	Belongs to the RtcB family
P40_01870	COG1804	L-carnitine dehydratase bile acid-inducible protein F
P40_01880	COG4399	Belongs to the UPF0754 family
P40_01890	COG0346	lactoylglutathione lyase activity
P40_01935	COG2205	protein histidine kinase activity
P40_01940	COG0745	RESPONSE REGULATOR receiver
P40_01955	COG0318	PFAM AMP-dependent synthetase and ligase
P40_01975	COG3795	YCII-related domain
P40_01980	COG4941	Belongs to the sigma-70 factor family
P40_02000	COG0659	secondary active sulfate transmembrane transporter activity
P40_02015	COG2321	neutral zinc metallopeptidase
P40_02035	COG0515	serine threonine protein kinase
P40_02035	COG2815	serine threonine protein kinase
P40_02040	COG2116	formate transmembrane transporter activity
P40_02045	COG0586	Pfam SNARE associated Golgi protein
P40_02050	COG0625	glutathione transferase activity
P40_02060	COG0583	DNA-binding transcription factor activity
P40_02070	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
P40_02090	COG0513	Belongs to the DEAD box helicase family
P40_02115	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
P40_02120	COG2217	Heavy metal translocating P-type atpase
P40_02140	COG1051	belongs to the nudix hydrolase family
P40_02145	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
P40_02155	COG0730	response to heat
P40_02160	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
P40_02165	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
P40_02210	COG0488	(ABC) transporter
P40_02220	COG1742	UPF0060 membrane protein
P40_02245	COG1960	acyl-CoA dehydrogenase activity
P40_02260	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
P40_02260	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
P40_02265	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
P40_02270	COG0439	Biotin carboxylase
P40_02280	COG0318	PFAM AMP-dependent synthetase and ligase
P40_02285	COG0545	Peptidyl-prolyl cis-trans isomerase
P40_02305	COG1346	cytolysis
P40_02315	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
P40_02320	COG2918	glutathione biosynthetic process
P40_02325	COG2183	response to ionizing radiation
P40_02335	COG0745	RESPONSE REGULATOR receiver
P40_02340	COG2205	protein histidine kinase activity
P40_02345	COG2814	Major facilitator Superfamily
P40_02350	COG0129	dihydroxy-acid dehydratase activity
P40_02360	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
P40_02365	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
P40_02375	COG2133	pyrroloquinoline quinone binding
P40_02380	COG0625	glutathione transferase activity
P40_02400	COG1309	transcriptional regulator
P40_02420	COG1595	DNA-templated transcription, initiation
P40_02425	COG3712	iron ion homeostasis
P40_02430	COG4771	TonB-dependent receptor
P40_02440	COG2951	lytic endotransglycosylase activity
P40_02450	COG1252	NADH dehydrogenase
P40_02455	COG0318	PFAM AMP-dependent synthetase and ligase
P40_02460	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
P40_02465	COG1012	belongs to the aldehyde dehydrogenase family
P40_02485	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
P40_02495	COG3391	amine dehydrogenase activity
P40_02510	COG2207	Transcriptional regulator
P40_02515	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
P40_02520	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
P40_02525	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
P40_02530	COG1011	Hydrolase
P40_02535	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
P40_02545	COG0494	nUDIX hydrolase
P40_02550	COG1218	3'(2'),5'-bisphosphate nucleotidase
P40_02590	COG0318	PFAM AMP-dependent synthetase and ligase
P40_02595	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
P40_02605	COG0747	negative chemotaxis
P40_02610	COG4608	Belongs to the ABC transporter superfamily
P40_02615	COG0444	Belongs to the ABC transporter superfamily
P40_02625	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
P40_02630	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
P40_02700	COG3830	Belongs to the UPF0237 family
P40_02700	COG0560	Phosphoserine phosphatase
P40_02720	COG0131	Imidazoleglycerol-phosphate dehydratase
P40_02725	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
P40_02730	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
P40_02735	COG0107	imidazoleglycerol-phosphate synthase activity
P40_02740	COG1671	Belongs to the UPF0178 family
P40_02755	COG0385	Bile acid
P40_02760	COG2223	nitrite transmembrane transporter activity
P40_02770	COG0243	molybdopterin cofactor binding
P40_02775	COG0746	molybdenum cofactor guanylyltransferase activity
P40_02790	COG0314	molybdopterin synthase activity
P40_02795	COG0521	Mo-molybdopterin cofactor biosynthetic process
P40_02795	COG0315	cyclic pyranopterin monophosphate synthase activity
P40_02800	COG0303	'Molybdopterin
P40_02805	COG0793	Belongs to the peptidase S41A family
P40_02810	COG4942	peptidase
P40_02815	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
P40_02825	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
P40_02830	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
P40_02835	COG3237	CsbD-like
P40_02855	COG0189	ligase activity
P40_02860	COG3083	sulfuric ester hydrolase activity
P40_02865	COG0482	sulfurtransferase activity
P40_02875	COG0174	glutamine synthetase
P40_02890	COG3852	Histidine kinase
P40_02895	COG2204	response regulator
P40_02905	COG1490	D-aminoacyl-tRNA deacylase activity
P40_02920	COG3064	Membrane
P40_02920	COG1073	alpha beta
P40_02920	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
P40_02930	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
P40_02935	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
P40_02940	COG0140	phosphoribosyl-ATP diphosphatase activity
P40_02945	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
P40_02955	COG2226	methyltransferase
P40_02965	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
P40_02965	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
P40_02970	COG0306	phosphate transporter
P40_02975	COG1392	Phosphate transport regulator
P40_02995	COG0859	PFAM glycosyl transferase family 9
P40_03005	COG0859	PFAM glycosyl transferase family 9
P40_03010	COG0438	transferase activity, transferring glycosyl groups
P40_03045	COG1560	Kdo2-lipid A biosynthetic process
P40_03055	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
P40_03055	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
P40_03060	COG2207	Transcriptional regulator
P40_03070	COG0667	Aldo Keto reductase
P40_03080	COG1519	Transferase
P40_03085	COG1538	Outer membrane efflux protein
P40_03090	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
P40_03095	COG0494	nUDIX hydrolase
P40_03105	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
P40_03130	COG3321	synthase
P40_03130	COG0604	alcohol dehydrogenase
P40_03135	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
P40_03145	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
P40_03155	COG0183	Belongs to the thiolase family
P40_03160	COG4566	intracellular signal transduction
P40_03165	COG5507	3-demethylubiquinone-9 3-methyltransferase
P40_03170	COG1283	sodium-dependent phosphate transmembrane transporter activity
P40_03175	COG3150	esterase
P40_03190	COG0204	Acyl-transferase
P40_03200	COG3122	Protein conserved in bacteria
P40_03210	COG2366	antibiotic biosynthetic process
P40_03215	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
P40_03230	COG0596	Alpha beta hydrolase
P40_03240	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
P40_03245	COG1509	lysine 2,3-aminomutase activity
P40_03280	COG1024	Enoyl-CoA hydratase
P40_03305	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
P40_03310	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
P40_03315	COG0583	DNA-binding transcription factor activity
P40_03320	COG0667	Aldo Keto reductase
P40_03330	COG1024	Enoyl-CoA hydratase
P40_03350	COG0473	3-isopropylmalate dehydrogenase activity
P40_03355	COG1902	pentaerythritol trinitrate reductase activity
P40_03360	COG2207	Transcriptional regulator
P40_03365	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
P40_03380	COG3781	membrane
P40_03385	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
P40_03390	COG2375	cellular response to nickel ion
P40_03400	COG3239	Fatty acid desaturase
P40_03415	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
P40_03420	COG0259	pyridoxamine-phosphate oxidase activity
P40_03435	COG2161	toxin-antitoxin pair type II binding
P40_03450	COG0410	ABC transporter
P40_03465	COG0559	Belongs to the binding-protein-dependent transport system permease family
P40_03475	COG1802	Transcriptional regulator
P40_03480	COG0439	Biotin carboxylase
P40_03490	COG0583	DNA-binding transcription factor activity
P40_03515	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
P40_03530	COG1335	isochorismatase
P40_03555	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
P40_03560	COG1194	a g-specific adenine glycosylase
P40_03575	COG0688	phosphatidylethanolamine metabolic process
P40_03585	COG1162	GTPase activity
P40_03590	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
P40_03610	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
P40_03610	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
P40_03615	COG0802	atpase or kinase
P40_03620	COG0860	N-Acetylmuramoyl-L-alanine amidase
P40_03625	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
P40_03630	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
P40_03635	COG1923	regulation of RNA biosynthetic process
P40_03640	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
P40_03645	COG0330	HflC and HflK could
P40_03650	COG0330	HflC and HflK could
P40_03660	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
P40_03665	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
P40_03680	COG1785	Belongs to the alkaline phosphatase family
P40_03685	COG1785	Belongs to the alkaline phosphatase family
P40_03715	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
P40_03720	COG0360	Binds together with S18 to 16S ribosomal RNA
P40_03730	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
P40_03735	COG0359	binds to the 23S rRNA
P40_03740	COG0305	Participates in initiation and elongation during chromosome replication
P40_03745	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
P40_03750	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
P40_03755	COG0569	domain protein
P40_03760	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
P40_03785	COG2226	methyltransferase
P40_03800	COG2259	Doxx family
P40_03810	COG1595	DNA-templated transcription, initiation
P40_03815	COG0488	(ABC) transporter
P40_03825	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
P40_03835	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
P40_03840	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
P40_03840	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
P40_03870	COG3396	Phenylacetate-CoA oxygenase
P40_03875	COG3460	Phenylacetate-CoA oxygenase
P40_03880	COG3396	Phenylacetate-CoA oxygenase
P40_03885	COG2151	metal-sulfur cluster biosynthetic enzyme
P40_03890	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
P40_03895	COG2030	dehydratase
P40_03895	COG1012	belongs to the aldehyde dehydrogenase family
P40_03915	COG1403	HNH endonuclease
P40_03920	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
P40_03935	COG0737	Belongs to the 5'-nucleotidase family
P40_03940	COG0456	acetyltransferase
P40_03975	COG0559	Belongs to the binding-protein-dependent transport system permease family
P40_03985	COG3327	negative regulation of DNA-templated transcription, initiation
P40_03990	COG1024	Enoyl-CoA hydratase
P40_03995	COG2050	protein possibly involved in aromatic compounds catabolism
P40_04000	COG0183	Belongs to the thiolase family
P40_04035	COG0583	DNA-binding transcription factor activity
P40_04060	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
P40_04065	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
P40_04070	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
P40_04075	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
P40_04080	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
P40_04085	COG0142	geranyltranstransferase activity
P40_04105	COG0745	RESPONSE REGULATOR receiver
P40_04110	COG3539	Fimbrial protein
P40_04115	COG3121	Chaperone
P40_04125	COG3539	Fimbrial protein
P40_04135	COG0784	Response regulator, receiver
P40_04135	COG2205	protein histidine kinase activity
P40_04145	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
P40_04165	COG5002	protein histidine kinase activity
P40_04175	COG0662	Cupin 2, conserved barrel domain protein
P40_04180	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
P40_04190	COG1846	Transcriptional regulator
P40_04195	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
P40_04205	COG1469	GTP cyclohydrolase I activity
P40_04235	COG0215	cysteine-tRNA ligase activity
P40_04240	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
P40_04250	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
P40_04250	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
P40_04255	COG3706	GGDEF domain
P40_04255	COG2203	Gaf domain
P40_04255	COG5001	Diguanylate cyclase
P40_04255	COG4251	negative regulation of phosphorylation
P40_04275	COG0537	adenosine 5'-monophosphoramidase activity
P40_04290	COG1307	EDD domain protein, DegV family
P40_04310	COG0300	oxidoreductase activity
P40_04345	COG1335	isochorismatase
P40_04355	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
P40_04360	COG2835	tetraacyldisaccharide 4'-kinase activity
P40_04365	COG1960	acyl-CoA dehydrogenase activity
P40_04370	COG2832	Protein of unknown function (DUF454)
P40_04375	COG1960	acyl-CoA dehydrogenase activity
P40_04425	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
P40_04465	COG2771	luxR family
P40_04545	COG2354	Protein conserved in bacteria
P40_04550	COG0318	PFAM AMP-dependent synthetase and ligase
P40_04555	COG1024	Enoyl-CoA hydratase
P40_04580	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
P40_04595	COG0828	Belongs to the bacterial ribosomal protein bS21 family
P40_04600	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
P40_04605	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
P40_04610	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
P40_04625	COG1028	Short-chain dehydrogenase reductase Sdr
P40_04630	COG0617	tRNA 3'-terminal CCA addition
P40_04640	COG2719	SpoVR family
P40_04645	COG2718	Belongs to the UPF0229 family
P40_04650	COG2766	serine protein kinase
P40_04660	COG2967	ApaG domain
P40_04665	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
P40_04670	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
P40_04675	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
P40_04680	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
P40_04695	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
P40_04705	COG0791	NLP P60 protein
P40_04720	COG0477	Major facilitator Superfamily
P40_04725	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
P40_04730	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
P40_04735	COG1845	cytochrome c oxidase, subunit III
P40_04740	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
P40_04755	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
P40_04760	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
P40_04765	COG0512	Glutamine amidotransferase of anthranilate synthase
P40_04770	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
P40_04775	COG0134	indole-3-glycerol-phosphate synthase activity
P40_04785	COG1765	OsmC-like protein
P40_04790	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
P40_04795	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
P40_04800	COG0784	Response regulator, receiver
P40_04800	COG2205	protein histidine kinase activity
P40_04800	COG5002	protein histidine kinase activity
P40_04805	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
P40_04810	COG0730	response to heat
P40_04815	COG0151	Belongs to the GarS family
P40_04820	COG0138	bifunctional purine biosynthesis protein purh
P40_04840	COG2264	protein methyltransferase activity
P40_04860	COG0511	ligase activity, forming carbon-carbon bonds
P40_04865	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
P40_04880	COG2226	methyltransferase
P40_04905	COG0642	Histidine kinase
P40_04925	COG0318	PFAM AMP-dependent synthetase and ligase
P40_04935	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
P40_04945	COG2233	PERMEase
P40_04990	COG0205	6-phosphofructokinase activity
P40_05005	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
P40_05010	COG0163	prenyltransferase activity
P40_05015	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
P40_05030	COG0811	peptide transport
P40_05035	COG3015	lipoprotein NlpE involved in copper resistance
P40_05060	COG1846	Transcriptional regulator
P40_05065	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
P40_05070	COG0321	lipoyl(octanoyl) transferase activity
P40_05085	COG1686	Belongs to the peptidase S11 family
P40_05095	COG2951	lytic endotransglycosylase activity
P40_05100	COG0772	Belongs to the SEDS family
P40_05105	COG0768	penicillin binding
P40_05110	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
P40_05125	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
P40_05145	COG0495	leucyl-tRNA aminoacylation
P40_05155	COG0471	metal ion transport
P40_05160	COG0659	secondary active sulfate transmembrane transporter activity
P40_05165	COG0446	pyridine nucleotide-disulphide oxidoreductase
P40_05180	COG0815	Transfers the fatty acyl group on membrane lipoproteins
P40_05185	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
P40_05190	COG4535	Mg2 and Co2 transporter CorC
P40_05195	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
P40_05200	COG1702	phosphate starvation-inducible protein PhoH
P40_05205	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
P40_05210	COG4208	sulfate ABC transporter
P40_05220	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
P40_05230	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
P40_05235	COG1999	signal sequence binding
P40_05275	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
P40_05290	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
P40_05325	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
P40_05330	COG1278	Cold shock
P40_05345	COG0501	Belongs to the peptidase M48B family
P40_05350	COG1704	LemA family
P40_05355	COG0109	protoheme IX farnesyltransferase activity
P40_05360	COG1612	heme a metabolic process
P40_05390	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
P40_05395	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
P40_05400	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
P40_05465	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
P40_05470	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
P40_05475	COG1022	Amp-dependent synthetase and ligase
P40_05485	COG0559	Belongs to the binding-protein-dependent transport system permease family
P40_05510	COG3284	Transcriptional regulator
P40_05525	COG0439	Biotin carboxylase
P40_05545	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
P40_05570	COG2827	Endonuclease containing a URI domain
P40_05580	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
P40_05605	COG0071	Belongs to the small heat shock protein (HSP20) family
P40_05625	COG2963	transposase activity
P40_05630	COG2801	Transposase and inactivated derivatives
P40_05640	COG1959	2 iron, 2 sulfur cluster binding
P40_05645	COG1104	cysteine desulfurase activity
P40_05655	COG2166	iron-sulfur cluster assembly
P40_05660	COG2151	metal-sulfur cluster biosynthetic enzyme
P40_05665	COG0316	Belongs to the HesB IscA family
P40_05670	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
P40_05675	COG0719	Fe-S assembly protein
P40_05680	COG0396	ATPase activity
P40_05685	COG0719	Fe-S assembly protein
P40_05690	COG0105	UTP biosynthetic process
P40_05695	COG0820	rRNA (adenine-C2-)-methyltransferase activity
P40_05710	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
P40_05715	COG0124	histidyl-tRNA synthetase
P40_05730	COG1160	GTP binding
P40_05745	COG5002	protein histidine kinase activity
P40_05745	COG2205	protein histidine kinase activity
P40_05745	COG0784	Response regulator, receiver
P40_05750	COG1570	exodeoxyribonuclease VII activity
P40_05760	COG0519	Catalyzes the synthesis of GMP from XMP
P40_05760	COG0518	GMP synthase (glutamine-hydrolyzing) activity
P40_05770	COG1230	cation diffusion facilitator family transporter
P40_05815	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
P40_05835	COG1752	Esterase of the alpha-beta hydrolase superfamily
P40_05840	COG1741	Belongs to the pirin family
P40_05845	COG1846	Transcriptional regulator
P40_05845	COG0456	acetyltransferase
P40_05880	COG0653	protein targeting
P40_05890	COG3609	addiction module antidote protein, CC2985 family
P40_05940	COG1304	FMN binding
P40_05985	COG0024	Methionine aminopeptidase
P40_06010	COG1733	regulation of RNA biosynthetic process
P40_06015	COG2814	Major facilitator Superfamily
P40_06065	COG0662	Cupin 2, conserved barrel domain protein
P40_06065	COG2207	Transcriptional regulator
P40_06085	COG3457	Alanine racemase
P40_06100	COG2207	Transcriptional regulator
P40_06120	COG3541	Predicted nucleotidyltransferase
P40_06145	COG0625	glutathione transferase activity
P40_06165	COG0693	protein deglycase activity
P40_06170	COG4638	Rieske (2fe-2S)
P40_06180	COG0667	Aldo Keto reductase
P40_06225	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
P40_06255	COG2226	methyltransferase
P40_06280	COG4993	Dehydrogenase
P40_06290	COG0477	Major facilitator Superfamily
P40_06300	COG0583	DNA-binding transcription factor activity
P40_06305	COG1960	acyl-CoA dehydrogenase activity
P40_06310	COG1804	L-carnitine dehydratase bile acid-inducible protein F
P40_06315	COG3795	YCII-related domain
P40_06330	COG0477	Major facilitator Superfamily
P40_06340	COG0583	DNA-binding transcription factor activity
P40_06345	COG1309	transcriptional regulator
P40_06360	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
P40_06370	COG1309	transcriptional regulator
P40_06375	COG1028	Short-chain dehydrogenase reductase Sdr
P40_06380	COG2910	NAD(P)H-binding
P40_06400	COG1121	(ABC) transporter
P40_06405	COG1108	ABC-type Mn2 Zn2 transport systems permease components
P40_06410	COG1108	ABC-type Mn2 Zn2 transport systems permease components
P40_06415	COG2259	Doxx family
P40_06435	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
P40_06450	COG1024	Enoyl-CoA hydratase
P40_06455	COG3258	Cytochrome c
P40_06460	COG0183	Belongs to the thiolase family
P40_06475	COG1309	transcriptional regulator
P40_06500	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
P40_06505	COG0590	tRNA wobble adenosine to inosine editing
P40_06510	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
P40_06525	COG3323	Protein of unknown function (DUF1653)
P40_06525	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
P40_06530	COG2816	NAD+ diphosphatase activity
P40_06535	COG0494	nUDIX hydrolase
P40_06550	COG1752	Esterase of the alpha-beta hydrolase superfamily
P40_06555	COG4536	flavin adenine dinucleotide binding
P40_06565	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
P40_06570	COG0228	four-way junction DNA binding
P40_06575	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
P40_06580	COG0336	Belongs to the RNA methyltransferase TrmD family
P40_06585	COG0335	large ribosomal subunit rRNA binding
P40_06590	COG2261	transglycosylase associated protein
P40_06605	COG0436	Aminotransferase
P40_06615	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
P40_06645	COG1804	L-carnitine dehydratase bile acid-inducible protein F
P40_06650	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
P40_06655	COG2264	protein methyltransferase activity
P40_06660	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
P40_06690	COG4953	penicillin-binding protein 1C
P40_06725	COG3264	Mechanosensitive ion channel
P40_06725	COG1196	nuclear chromosome segregation
P40_06740	COG0709	Synthesizes selenophosphate from selenide and ATP
P40_06745	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
P40_06755	COG1309	transcriptional regulator
P40_06780	COG3030	protein affecting phage T7 exclusion by the F plasmid
P40_06790	COG0183	Belongs to the thiolase family
P40_06795	COG1946	Acyl-CoA thioesterase
P40_06810	COG0745	RESPONSE REGULATOR receiver
P40_06815	COG2205	protein histidine kinase activity
P40_06825	COG1902	pentaerythritol trinitrate reductase activity
P40_06825	COG0446	pyridine nucleotide-disulphide oxidoreductase
P40_06830	COG1960	acyl-CoA dehydrogenase activity
P40_06835	COG1960	acyl-CoA dehydrogenase activity
P40_06860	COG1115	amino acid carrier protein
P40_06890	COG3360	Dodecin
P40_06895	COG0513	Belongs to the DEAD box helicase family
P40_06925	COG4771	TonB-dependent receptor
P40_06935	COG0175	sulfate reduction
P40_06940	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
P40_06940	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
P40_06970	COG0488	(ABC) transporter
P40_07020	COG0183	Belongs to the thiolase family
P40_07025	COG1250	3-hydroxyacyl-CoA dehydrogenase
P40_07025	COG1024	Enoyl-CoA hydratase
P40_07030	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
P40_07045	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
P40_07055	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
P40_07060	COG1024	Enoyl-CoA hydratase
P40_07065	COG2070	2-Nitropropane dioxygenase
P40_07110	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
P40_07115	COG0481	GTPase activity
P40_07120	COG0681	Belongs to the peptidase S26 family
P40_07130	COG0571	ribonuclease III activity
P40_07135	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
P40_07140	COG1381	Involved in DNA repair and RecF pathway recombination
P40_07145	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
P40_07160	COG5002	protein histidine kinase activity
P40_07160	COG0784	Response regulator, receiver
P40_07160	COG2205	protein histidine kinase activity
P40_07175	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
P40_07180	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
P40_07185	COG3956	TIGRFAM MazG family protein
P40_07195	COG0789	Transcriptional regulator
P40_07225	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
P40_07235	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
P40_07240	COG3088	subunit of a heme lyase
P40_07250	COG0563	adenylate kinase activity
P40_07275	COG0511	ligase activity, forming carbon-carbon bonds
P40_07275	COG5016	pyruvate
P40_07280	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
P40_07295	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
P40_07295	COG1116	anion transmembrane transporter activity
P40_07300	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
P40_07305	COG1116	anion transmembrane transporter activity
P40_07315	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
P40_07315	COG1116	anion transmembrane transporter activity
P40_07320	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
P40_07325	COG0583	DNA-binding transcription factor activity
P40_07330	COG2076	Multidrug Resistance protein
P40_07340	COG4133	protoheme IX ABC transporter activity
P40_07360	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
P40_07410	COG1028	Short-chain dehydrogenase reductase Sdr
P40_07445	COG1131	(ABC) transporter
P40_07450	COG0842	Transport permease protein
P40_07455	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
P40_07455	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
P40_07460	COG2801	Transposase and inactivated derivatives
P40_07470	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
P40_07480	COG0778	Nitroreductase
P40_07540	COG0583	DNA-binding transcription factor activity
P40_07545	COG0596	Alpha beta hydrolase
P40_07585	COG0318	PFAM AMP-dependent synthetase and ligase
P40_07590	COG2271	Major facilitator Superfamily
P40_07600	COG0183	Belongs to the thiolase family
P40_07605	COG1028	Short-chain dehydrogenase reductase Sdr
P40_07615	COG1960	acyl-CoA dehydrogenase activity
P40_07620	COG1960	acyl-CoA dehydrogenase activity
P40_07625	COG1309	transcriptional regulator
P40_07630	COG1024	Enoyl-CoA hydratase
P40_07650	COG1028	Short-chain dehydrogenase reductase Sdr
P40_07670	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
P40_07710	COG2205	protein histidine kinase activity
P40_07710	COG0784	Response regulator, receiver
P40_07740	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
P40_07745	COG1012	belongs to the aldehyde dehydrogenase family
P40_07760	COG1538	Outer membrane efflux protein
P40_07765	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
P40_07770	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
P40_07775	COG1309	transcriptional regulator
P40_07780	COG1028	Short-chain dehydrogenase reductase Sdr
P40_07795	COG0318	PFAM AMP-dependent synthetase and ligase
P40_07800	COG0559	Belongs to the binding-protein-dependent transport system permease family
P40_07810	COG0411	ABC transporter
P40_07815	COG0410	ABC transporter
P40_07825	COG1024	Enoyl-CoA hydratase
P40_07825	COG1250	3-hydroxyacyl-CoA dehydrogenase
P40_07830	COG1960	acyl-CoA dehydrogenase activity
P40_07835	COG1960	acyl-CoA dehydrogenase activity
P40_07840	COG2130	NADP-dependent
P40_07850	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
P40_07855	COG4774	siderophore transport
P40_07880	COG1487	ribonuclease activity
P40_07885	COG0280	phosphate acetyltransferase
P40_07885	COG0281	malic enzyme
P40_07890	COG0235	Class ii aldolase
P40_07905	COG1487	ribonuclease activity
P40_07925	COG2030	dehydratase
P40_07930	COG1960	acyl-CoA dehydrogenase activity
P40_07935	COG1024	Enoyl-CoA hydratase
P40_07940	COG1960	acyl-CoA dehydrogenase activity
P40_07945	COG1028	Short-chain dehydrogenase reductase Sdr
P40_07985	COG0183	Belongs to the thiolase family
P40_07990	COG1846	Transcriptional regulator
P40_07995	COG1764	response to oxidative stress
P40_08025	COG1739	Uncharacterized protein family UPF0029
P40_08055	COG0471	metal ion transport
P40_08055	COG3273	potassium ion transport
P40_08060	COG0529	Catalyzes the synthesis of activated sulfate
P40_08095	COG1078	dGTPase activity
P40_08105	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
P40_08120	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
P40_08135	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
P40_08145	COG1210	Utp--glucose-1-phosphate uridylyltransferase
P40_08170	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
P40_08175	COG2755	lipolytic protein G-D-S-L family
P40_08175	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
P40_08275	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
P40_08285	COG0183	Belongs to the thiolase family
P40_08290	COG0318	PFAM AMP-dependent synthetase and ligase
P40_08370	COG2801	Transposase and inactivated derivatives
P40_08375	COG3791	Glutathione-dependent formaldehyde-activating
P40_08390	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
P40_08395	COG3657	addiction module killer protein
P40_08405	COG3115	cell septum assembly
P40_08410	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
P40_08420	COG3089	Belongs to the UPF0270 family
P40_08425	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
P40_08425	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
P40_08435	COG2267	carboxylic ester hydrolase activity
P40_08445	COG2205	protein histidine kinase activity
P40_08445	COG0784	Response regulator, receiver
P40_08445	COG5002	protein histidine kinase activity
P40_08455	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
P40_08475	COG4106	trans-aconitate 2-methyltransferase activity
P40_08480	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
P40_08510	COG1028	Short-chain dehydrogenase reductase Sdr
P40_08515	COG0583	DNA-binding transcription factor activity
P40_08530	COG0318	PFAM AMP-dependent synthetase and ligase
P40_08545	COG1024	Enoyl-CoA hydratase
P40_08550	COG1960	acyl-CoA dehydrogenase activity
P40_08555	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
P40_08595	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
P40_08600	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
P40_08610	COG0308	aminopeptidase N
P40_08620	COG0167	dihydroorotate dehydrogenase activity
P40_08630	COG3130	regulation of translation
P40_08635	COG0116	Belongs to the methyltransferase superfamily
P40_08635	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
P40_08645	COG0084	hydrolase, TatD family'
P40_08655	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
P40_08665	COG0589	response to stress
P40_08685	COG1309	transcriptional regulator
P40_08690	COG1376	ErfK ybiS ycfS ynhG family protein
P40_08700	COG0668	transmembrane transport
P40_08750	COG2081	HI0933 family
P40_08755	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
P40_08760	COG1946	Acyl-CoA thioesterase
P40_08770	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
P40_08790	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
P40_08795	COG2871	sodium ion transport
P40_08800	COG1477	protein flavinylation
P40_08805	COG2991	Protein conserved in bacteria
P40_08820	COG0584	glycerophosphoryl diester phosphodiesterase
P40_08845	COG0583	DNA-binding transcription factor activity
P40_08865	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
P40_08870	COG2957	Belongs to the agmatine deiminase family
P40_08885	COG1136	(ABC) transporter
P40_08890	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
P40_08900	COG0714	Associated with various cellular activities
P40_08935	COG1393	Belongs to the ArsC family
P40_08940	COG1959	2 iron, 2 sulfur cluster binding
P40_08940	COG1295	ribonuclease BN
P40_08945	COG1254	Belongs to the acylphosphatase family
P40_08985	COG1024	Enoyl-CoA hydratase
P40_09005	COG0410	ABC transporter
P40_09020	COG1028	Short-chain dehydrogenase reductase Sdr
P40_09025	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
P40_09030	COG2894	cell division
P40_09035	COG0850	regulation of cytokinetic process
P40_09045	COG3550	peptidyl-serine autophosphorylation
P40_09060	COG3118	belongs to the thioredoxin family
P40_09065	COG0004	ammonium transporteR
P40_09070	COG2326	polyphosphate kinase activity
P40_09080	COG1199	ATP-dependent helicase activity
P40_09095	COG1968	undecaprenyl-diphosphatase activity
P40_09100	COG0742	ribosomal rna small subunit methyltransferase
P40_09105	COG2937	Belongs to the GPAT DAPAT family
P40_09125	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
P40_09130	COG2171	N-acyltransferase activity
P40_09135	COG1393	Belongs to the ArsC family
P40_09140	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
P40_09145	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
P40_09150	COG0024	Methionine aminopeptidase
P40_09155	COG0052	Belongs to the universal ribosomal protein uS2 family
P40_09160	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
P40_09165	COG0528	UMP kinase activity
P40_09170	COG0233	cytoplasmic translational termination
P40_09175	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
P40_09180	COG0575	Belongs to the CDS family
P40_09185	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
P40_09205	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
P40_09210	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
P40_09220	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
P40_09225	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
P40_09230	COG0587	DNA-directed DNA polymerase activity
P40_09235	COG0825	malonyl-CoA metabolic process
P40_09240	COG0037	tRNA processing
P40_09245	COG0504	CTP synthase activity
P40_09250	COG2877	3-deoxy-8-phosphooctulonate synthase activity
P40_09255	COG0148	phosphopyruvate hydratase activity
P40_09260	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
P40_09270	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
P40_09275	COG0585	pseudouridine synthase activity
P40_09280	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
P40_09320	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
P40_09330	COG0300	oxidoreductase activity
P40_09335	COG0037	tRNA processing
P40_09340	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
P40_09345	COG0583	DNA-binding transcription factor activity
P40_09350	COG2814	Major facilitator Superfamily
P40_09355	COG0667	Aldo Keto reductase
P40_09360	COG0667	Aldo Keto reductase
P40_09375	COG0220	tRNA (guanine-N7-)-methyltransferase activity
P40_09385	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
P40_09395	COG2850	peptidyl-arginine hydroxylation
P40_09405	COG2915	High frequency lysogenization protein hflD homolog
P40_09410	COG0482	sulfurtransferase activity
P40_09430	COG1278	Cold shock
P40_09435	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
P40_09440	COG0542	response to heat
P40_09445	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
P40_09450	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
P40_09455	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
P40_09465	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
P40_09470	COG0492	ferredoxin-NADP+ reductase activity
P40_09475	COG1674	ftsk spoiiie
P40_09480	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
P40_09485	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
P40_09490	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
P40_09495	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
P40_09500	COG1648	precorrin-2 dehydrogenase activity
P40_09500	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
P40_09505	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
P40_09520	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
P40_09545	COG2274	protein secretion by the type I secretion system
P40_09550	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
P40_09555	COG0596	Alpha beta hydrolase
P40_09570	COG3243	poly(R)-hydroxyalkanoic acid synthase
P40_09590	COG1028	Short-chain dehydrogenase reductase Sdr
P40_09605	COG0477	Major facilitator Superfamily
P40_09620	COG1028	Short-chain dehydrogenase reductase Sdr
P40_09645	COG1960	acyl-CoA dehydrogenase activity
P40_09650	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
P40_09665	COG0318	PFAM AMP-dependent synthetase and ligase
P40_09680	COG1960	acyl-CoA dehydrogenase activity
P40_09685	COG0318	PFAM AMP-dependent synthetase and ligase
P40_09690	COG1802	Transcriptional regulator
P40_09700	COG1280	lysine exporter protein (LysE YggA)
P40_09705	COG0003	Pfam Anion-transporting ATPase
P40_09715	COG1966	Carbon starvation protein
P40_09725	COG0322	excinuclease ABC activity
P40_09730	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
P40_09790	COG0318	PFAM AMP-dependent synthetase and ligase
P40_09795	COG1960	acyl-CoA dehydrogenase activity
P40_09850	COG1021	2,3-dihydroxybenzoate-AMP ligase
P40_09855	COG0318	PFAM AMP-dependent synthetase and ligase
P40_09865	COG1028	Short-chain dehydrogenase reductase Sdr
P40_09875	COG2030	dehydratase
P40_09880	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
P40_09925	COG0633	Ferredoxin
P40_09945	COG1309	transcriptional regulator
P40_09955	COG2801	Transposase and inactivated derivatives
P40_09995	COG3209	COG3209 Rhs family protein
P40_10080	COG1074	ATP-dependent DNA helicase activity
P40_10255	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
P40_10345	COG1192	Involved in chromosome partitioning
P40_10355	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
P40_10365	COG0411	ABC transporter
P40_10380	COG0683	leucine binding
P40_10415	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
P40_10420	COG0318	PFAM AMP-dependent synthetase and ligase
P40_10445	COG0318	PFAM AMP-dependent synthetase and ligase
P40_10630	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
P40_10645	COG3437	response regulator, receiver
P40_10705	COG1410	methionine synthase
P40_10705	COG0646	methionine synthase
P40_10720	COG2813	Specifically methylates the guanine in position
P40_10725	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
P40_10730	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
P40_10735	COG0235	Class ii aldolase
P40_10740	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
P40_10775	COG0560	Phosphoserine phosphatase
P40_10780	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
P40_10790	COG2816	NAD+ diphosphatase activity
P40_10800	COG0616	signal peptide processing
P40_10805	COG0604	alcohol dehydrogenase
P40_10820	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
P40_10830	COG0534	Mate efflux family protein
P40_10835	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
P40_10835	COG0316	Belongs to the HesB IscA family
P40_10845	COG0501	Belongs to the peptidase M48B family
P40_10850	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
P40_10865	COG0564	pseudouridine synthase activity
P40_10870	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
P40_10890	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
P40_10920	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
P40_10925	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
P40_10930	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
P40_10935	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
P40_10950	COG0700	Nucleoside recognition
P40_10960	COG0598	Magnesium transport protein CorA
P40_10975	COG3022	response to hydroperoxide
P40_10980	COG0589	response to stress
P40_10985	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
P40_11015	COG0348	domain, Protein
P40_11020	COG2010	Cytochrome c
P40_11035	COG3278	Belongs to the heme-copper respiratory oxidase family
P40_11045	COG1902	pentaerythritol trinitrate reductase activity
P40_11045	COG0446	pyridine nucleotide-disulphide oxidoreductase
P40_11065	COG0583	DNA-binding transcription factor activity
P40_11070	COG0583	DNA-binding transcription factor activity
P40_11075	COG2814	Major facilitator Superfamily
P40_11095	COG0330	HflC and HflK could
P40_11100	COG0697	spore germination
P40_11110	COG0542	response to heat
P40_11125	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
P40_11135	COG0180	Tryptophanyl-tRNA synthetase
P40_11140	COG0009	L-threonylcarbamoyladenylate synthase
P40_11145	COG0613	PHP domain protein
P40_11150	COG2917	probably involved in intracellular septation
P40_11155	COG2350	Protein conserved in bacteria
P40_11170	COG1804	L-carnitine dehydratase bile acid-inducible protein F
P40_11175	COG0204	Acyl-transferase
P40_11195	COG4181	ATPase activity
P40_11205	COG2814	Major facilitator Superfamily
P40_11220	COG1070	Carbohydrate kinase
P40_11225	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
P40_11230	COG0277	FAD linked oxidase domain protein
P40_11235	COG2885	chlorophyll binding
P40_11260	COG3243	poly(R)-hydroxyalkanoic acid synthase
P40_11265	COG3339	Conserved Protein
P40_11270	COG1192	Involved in chromosome partitioning
P40_11285	COG0069	glutamate synthase activity
P40_11290	COG0741	lytic transglycosylase activity
P40_11305	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
P40_11320	COG3344	reverse transcriptase
P40_11325	COG2079	MmgE PrpD family protein
P40_11330	COG2828	Protein conserved in bacteria
P40_11340	COG0372	Belongs to the citrate synthase family
P40_11345	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
P40_11350	COG1802	Transcriptional regulator
P40_11365	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
P40_11370	COG0328	RNA-DNA hybrid ribonuclease activity
P40_11380	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
P40_11385	COG0741	lytic transglycosylase activity
P40_11385	COG1388	LysM domain
P40_11390	COG4166	transmembrane transport
P40_11395	COG4174	ABC transporter (Permease)
P40_11400	COG4239	(ABC) transporter, permease
P40_11405	COG4172	Belongs to the ABC transporter superfamily
P40_11415	COG0737	Belongs to the 5'-nucleotidase family
P40_11420	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
P40_11435	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
P40_11440	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
P40_11445	COG0740	serine-type endopeptidase activity
P40_11450	COG0544	peptidyl-prolyl cis-trans isomerase activity
P40_11470	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
P40_11485	COG1289	transmembrane transporter activity
P40_11495	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
P40_11510	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
P40_11525	COG1309	transcriptional regulator
P40_11535	COG2814	Major facilitator Superfamily
P40_11545	COG2814	Major facilitator Superfamily
P40_11590	COG2301	Belongs to the HpcH HpaI aldolase family
P40_11595	COG2301	Belongs to the HpcH HpaI aldolase family
P40_11610	COG1960	acyl-CoA dehydrogenase activity
P40_11630	COG1960	acyl-CoA dehydrogenase activity
P40_11635	COG1960	acyl-CoA dehydrogenase activity
P40_11640	COG1024	Enoyl-CoA hydratase
P40_11645	COG1042	CoA-binding domain protein
P40_11645	COG0045	succinate-CoA ligase (ADP-forming) activity
P40_11645	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
P40_11660	COG2814	Major facilitator Superfamily
P40_11685	COG0438	transferase activity, transferring glycosyl groups
P40_11715	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
P40_11745	COG1643	Atp-dependent helicase
P40_11765	COG0583	DNA-binding transcription factor activity
P40_11785	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
P40_11805	COG0271	Belongs to the BolA IbaG family
P40_11820	COG0039	L-malate dehydrogenase activity
P40_11825	COG0517	IMP dehydrogenase activity
P40_11830	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
P40_11835	COG0702	epimerase
P40_11850	COG1960	acyl-CoA dehydrogenase activity
P40_11855	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
P40_11860	COG1024	Enoyl-CoA hydratase
P40_11870	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
P40_11885	COG0824	Thioesterase
P40_11910	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
P40_11920	COG0587	DNA-directed DNA polymerase activity
P40_11935	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
P40_11945	COG0589	response to stress
P40_11950	COG0659	secondary active sulfate transmembrane transporter activity
P40_11955	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
P40_11960	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
P40_11980	COG3220	belongs to the UPF0276 family
P40_11990	COG1028	Short-chain dehydrogenase reductase Sdr
P40_11995	COG1028	Short-chain dehydrogenase reductase Sdr
P40_12000	COG1960	acyl-CoA dehydrogenase activity
P40_12005	COG1024	Enoyl-CoA hydratase
P40_12010	COG0318	PFAM AMP-dependent synthetase and ligase
P40_12050	COG1643	Atp-dependent helicase
P40_12065	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
P40_12090	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
P40_12100	COG2271	Major facilitator Superfamily
P40_12125	COG4680	protein conserved in bacteria
P40_12130	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
P40_12135	COG4771	TonB-dependent receptor
P40_12140	COG1429	ligase activity, forming nitrogen-metal bonds
P40_12160	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
P40_12180	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
P40_12185	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
P40_12210	COG2356	endonuclease I
P40_12215	COG1802	Transcriptional regulator
P40_12320	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
P40_12335	COG0535	radical SAM domain protein
P40_12350	COG0625	glutathione transferase activity
P40_12360	COG0583	DNA-binding transcription factor activity
P40_12375	COG0745	RESPONSE REGULATOR receiver
P40_12380	COG5002	protein histidine kinase activity
P40_12415	COG3501	Rhs element vgr protein
P40_12420	COG2186	Transcriptional regulator
P40_12425	COG1620	l-lactate permease
P40_12430	COG0247	lactate metabolic process
P40_12435	COG1139	Iron-sulfur cluster binding protein
P40_12465	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
P40_12545	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
P40_12560	COG4574	serine-type endopeptidase inhibitor activity
P40_12595	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
P40_12600	COG1960	acyl-CoA dehydrogenase activity
P40_12605	COG1960	acyl-CoA dehydrogenase activity
P40_12610	COG1024	Enoyl-CoA hydratase
P40_12615	COG1024	Enoyl-CoA hydratase
P40_12620	COG1802	Transcriptional regulator
P40_12625	COG1960	acyl-CoA dehydrogenase activity
P40_12630	COG1960	acyl-CoA dehydrogenase activity
P40_12640	COG1804	L-carnitine dehydratase bile acid-inducible protein F
P40_12680	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
P40_12685	COG3622	Belongs to the hyi family
P40_12690	COG0672	)-iron permease
P40_12700	COG0436	Aminotransferase
P40_12710	COG0501	Belongs to the peptidase M48B family
P40_12715	COG0745	RESPONSE REGULATOR receiver
P40_12715	COG3706	GGDEF domain
P40_12740	COG0714	Associated with various cellular activities
P40_12755	COG1286	toxin biosynthetic process
P40_12765	COG0285	dihydrofolate synthase activity
P40_12770	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
P40_12775	COG0159	tryptophan synthase activity
P40_12780	COG0133	tryptophan synthase activity
P40_12785	COG0135	phosphoribosylanthranilate isomerase activity
P40_12790	COG0101	tRNA pseudouridine synthase activity
P40_12800	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
P40_12810	COG0473	3-isopropylmalate dehydrogenase activity
P40_12815	COG0066	3-isopropylmalate dehydratase activity
P40_12820	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
P40_12830	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
P40_12850	COG1301	dicarboxylic acid transport
P40_12865	COG3268	Saccharopine dehydrogenase
P40_12875	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
P40_12885	COG0708	Exodeoxyribonuclease III
P40_12900	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
P40_12905	COG0326	Molecular chaperone. Has ATPase activity
P40_12910	COG1090	epimerase
P40_12935	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
P40_12940	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
P40_12950	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
P40_12955	COG0045	succinate-CoA ligase (ADP-forming) activity
P40_12980	COG1053	succinate dehydrogenase
P40_12985	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
P40_12990	COG2009	succinate dehydrogenase
P40_13015	COG2084	Dehydrogenase
P40_13035	COG0579	oxidoreductase
P40_13045	COG1305	Transglutaminase-like
P40_13055	COG2308	Evidence 4 Homologs of previously reported genes of
P40_13080	COG0583	DNA-binding transcription factor activity
P40_13085	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
P40_13085	COG3153	acetyltransferase
P40_13095	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
P40_13100	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
P40_13110	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
P40_13115	COG2146	nitrite reductase [NAD(P)H] activity
P40_13120	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
P40_13120	COG2146	nitrite reductase [NAD(P)H] activity
P40_13150	COG1322	Protein conserved in bacteria
P40_13155	COG0084	hydrolase, TatD family'
P40_13170	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
P40_13175	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
P40_13180	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
P40_13185	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
P40_13190	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
P40_13205	COG0416	fatty acid biosynthetic process
P40_13210	COG0333	Belongs to the bacterial ribosomal protein bL32 family
P40_13220	COG0424	maF-like protein
P40_13230	COG0546	phosphoglycolate phosphatase activity
P40_13235	COG0564	pseudouridine synthase activity
P40_13240	COG1530	ribonuclease E activity
P40_13250	COG0812	UDP-N-acetylmuramate dehydrogenase activity
P40_13255	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
P40_13260	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
P40_13265	COG1663	tetraacyldisaccharide 4'-kinase activity
P40_13270	COG1132	(ABC) transporter
P40_13275	COG0848	biopolymer transport protein
P40_13280	COG0811	peptide transport
P40_13285	COG0658	competence protein
P40_13285	COG2333	competence protein COMEC
P40_13295	COG3101	peptidyl-lysine hydroxylation
P40_13300	COG0534	Mate efflux family protein
P40_13345	COG2223	nitrite transmembrane transporter activity
P40_13350	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
P40_13355	COG0788	formyltetrahydrofolate deformylase activity
P40_13360	COG2207	Transcriptional regulator
P40_13365	COG1309	transcriptional regulator
P40_13375	COG1131	(ABC) transporter
P40_13380	COG0842	Transport permease protein
P40_13390	COG4771	TonB-dependent receptor
P40_13440	COG4774	siderophore transport
P40_13445	COG3712	iron ion homeostasis
P40_13450	COG1595	DNA-templated transcription, initiation
P40_13455	COG1024	Enoyl-CoA hydratase
P40_13465	COG1960	acyl-CoA dehydrogenase activity
P40_13490	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
P40_13490	COG1042	CoA-binding domain protein
P40_13490	COG0045	succinate-CoA ligase (ADP-forming) activity
P40_13520	COG2193	ferroxidase activity
P40_13525	COG1024	Enoyl-CoA hydratase
P40_13525	COG1250	3-hydroxyacyl-CoA dehydrogenase
P40_13530	COG0183	Belongs to the thiolase family
P40_13540	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
P40_13550	COG2840	Smr protein MutS2
P40_13555	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
P40_13570	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
P40_13575	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
P40_13590	COG0717	Belongs to the dCTP deaminase family
P40_13595	COG0489	protein tyrosine kinase activity
P40_13610	COG0450	alkyl hydroperoxide reductase
P40_13650	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
P40_13655	COG1793	dna ligase
P40_13660	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
P40_13665	COG2813	Specifically methylates the guanine in position
P40_13670	COG0741	lytic transglycosylase activity
P40_13715	COG2205	protein histidine kinase activity
P40_13715	COG5002	protein histidine kinase activity
P40_13715	COG0784	Response regulator, receiver
P40_13720	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
P40_13720	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
P40_13735	COG4657	Part of a membrane complex involved in electron transport
P40_13740	COG2878	Part of a membrane complex involved in electron transport
P40_13745	COG4656	Part of a membrane complex involved in electron transport
P40_13750	COG4658	electron transport chain
P40_13755	COG4659	FMN binding
P40_13760	COG4660	Part of a membrane complex involved in electron transport
P40_13770	COG0786	glutamate:sodium symporter activity
P40_13775	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
P40_13780	COG1596	polysaccharide export
P40_13780	COG1555	photosystem II stabilization
P40_13785	COG0284	orotidine-5'-phosphate decarboxylase activity
P40_13790	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
P40_13800	COG0776	regulation of translation
P40_13810	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
P40_13815	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
P40_13820	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
P40_13825	COG0077	Prephenate dehydratase
P40_13825	COG1605	Chorismate mutase
P40_13840	COG0402	S-adenosylhomocysteine deaminase activity
P40_13845	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
P40_13850	COG0546	phosphoglycolate phosphatase activity
P40_13855	COG1028	Short-chain dehydrogenase reductase Sdr
P40_13900	COG2226	methyltransferase
P40_13915	COG2983	Belongs to the UPF0260 family
P40_13920	COG3100	YcgL domain-containing protein
P40_13925	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
P40_13930	COG0588	phosphoglycerate mutase activity
P40_13940	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
P40_13950	COG1960	acyl-CoA dehydrogenase activity
P40_13955	COG1454	alcohol dehydrogenase
P40_13960	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
P40_13965	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
P40_14000	COG1695	Transcriptional regulator
P40_14020	COG0427	acetyl-CoA hydrolase
P40_14035	COG1136	(ABC) transporter
P40_14050	COG0418	dihydroorotase activity
P40_14080	COG0318	PFAM AMP-dependent synthetase and ligase
P40_14095	COG0477	Major facilitator Superfamily
P40_14100	COG0235	Class ii aldolase
P40_14105	COG0583	DNA-binding transcription factor activity
P40_14115	COG0659	secondary active sulfate transmembrane transporter activity
P40_14120	COG0318	PFAM AMP-dependent synthetase and ligase
P40_14125	COG4191	Histidine kinase
P40_14130	COG4566	intracellular signal transduction
P40_14135	COG0583	DNA-binding transcription factor activity
P40_14145	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
P40_14165	COG2070	2-Nitropropane dioxygenase
P40_14170	COG3189	MarR family transcriptional regulator
P40_14190	COG1294	oxidase, subunit
P40_14200	COG4988	ABC transporter
P40_14205	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
P40_14230	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
P40_14240	COG2223	nitrite transmembrane transporter activity
P40_14245	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
P40_14250	COG1140	nitrate reductase beta subunit
P40_14255	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
P40_14260	COG2181	nitrate reductase activity
P40_14280	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
P40_14290	COG1959	2 iron, 2 sulfur cluster binding
P40_14295	COG1959	2 iron, 2 sulfur cluster binding
P40_14315	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
P40_14320	COG0840	transmembrane signaling receptor activity
P40_14355	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
P40_14360	COG0527	aspartate kinase activity
P40_14365	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
P40_14380	COG2137	regulation of response to DNA damage stimulus
P40_14390	COG1546	Belongs to the CinA family
P40_14455	COG4771	TonB-dependent receptor
P40_14465	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
P40_14470	COG1017	nitric oxide dioxygenase activity
P40_14470	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
P40_14480	COG1024	Enoyl-CoA hydratase
P40_14490	COG0318	PFAM AMP-dependent synthetase and ligase
P40_14495	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
P40_14500	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
P40_14545	COG1509	lysine 2,3-aminomutase activity
P40_14550	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
P40_14560	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
P40_14565	COG1074	ATP-dependent DNA helicase activity
P40_14570	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
P40_14580	COG3784	Protein of unknown function (DUF1318)
P40_14610	COG3077	Addiction module antitoxin, RelB DinJ family
P40_14710	COG2003	Belongs to the UPF0758 family
P40_14735	COG2963	transposase activity
P40_14740	COG2801	Transposase and inactivated derivatives
P40_14765	COG2608	mercury ion transmembrane transporter activity
P40_14805	COG2132	Multicopper oxidase
P40_14815	COG0745	RESPONSE REGULATOR receiver
P40_14820	COG0784	Response regulator, receiver
P40_14820	COG5002	protein histidine kinase activity
P40_14825	COG2003	Belongs to the UPF0758 family
P40_14885	COG0789	Transcriptional regulator
P40_14945	COG0776	regulation of translation
P40_14955	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
P40_14960	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
P40_14965	COG0291	Belongs to the bacterial ribosomal protein bL35 family
P40_14970	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
P40_14985	COG2186	Transcriptional regulator
P40_14995	COG1271	oxidase subunit
P40_15000	COG1294	oxidase, subunit
P40_15005	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
P40_15010	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
P40_15020	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
P40_15030	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
P40_15040	COG0425	Belongs to the sulfur carrier protein TusA family
P40_15045	COG4783	chaperone-mediated protein folding
P40_15050	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
P40_15060	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
P40_15065	COG0602	queuosine metabolic process
P40_15080	COG0823	Involved in the tonB-independent uptake of proteins
P40_15100	COG0824	Thioesterase
P40_15105	COG2255	four-way junction helicase activity
P40_15110	COG0632	four-way junction helicase activity
P40_15115	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
P40_15120	COG0217	transcriptional regulatory protein
P40_15125	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
P40_15145	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
P40_15150	COG0729	surface antigen
P40_15165	COG0442	prolyl-tRNA aminoacylation
P40_15175	COG1192	Involved in chromosome partitioning
P40_15180	COG1960	acyl-CoA dehydrogenase activity
P40_15185	COG1309	transcriptional regulator
P40_15195	COG0514	ATP-dependent DNA helicase (RecQ)
P40_15210	COG0513	Belongs to the DEAD box helicase family
P40_15215	COG1028	Short-chain dehydrogenase reductase Sdr
P40_15250	COG0189	ligase activity
P40_15255	COG4067	protein conserved in archaea
P40_15255	COG0189	ligase activity
P40_15260	COG0137	argininosuccinate synthase activity
P40_15265	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
P40_15280	COG0450	alkyl hydroperoxide reductase
P40_15300	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
P40_15305	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
P40_15310	COG3842	ATPase activity
P40_15315	COG0745	RESPONSE REGULATOR receiver
P40_15315	COG3706	GGDEF domain
P40_15320	COG3706	GGDEF domain
P40_15325	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
P40_15330	COG2205	protein histidine kinase activity
P40_15335	COG0745	RESPONSE REGULATOR receiver
P40_15340	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
P40_15340	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
P40_15345	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
P40_15370	COG4651	solute:proton antiporter activity
P40_15370	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
P40_15425	COG1012	belongs to the aldehyde dehydrogenase family
P40_15430	COG3384	dioxygenase
P40_15460	COG1846	Transcriptional regulator
P40_15465	COG0683	leucine binding
P40_15470	COG0861	Integral membrane protein TerC family
P40_15485	COG0601	transmembrane transport
P40_15495	COG0444	Belongs to the ABC transporter superfamily
P40_15500	COG4608	Belongs to the ABC transporter superfamily
P40_15505	COG0747	negative chemotaxis
P40_15520	COG2197	response regulator
P40_15575	COG0705	Rhomboid family
P40_15585	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
P40_15605	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
P40_15620	COG1335	isochorismatase
P40_15630	COG1028	Short-chain dehydrogenase reductase Sdr
P40_15635	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
P40_15640	COG1116	anion transmembrane transporter activity
P40_15665	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
P40_15685	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
P40_15690	COG1611	Belongs to the LOG family
P40_15705	COG1262	PFAM Formylglycine-generating sulfatase enzyme
P40_15710	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
P40_15740	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
P40_15745	COG0735	belongs to the Fur family
P40_15755	COG1960	acyl-CoA dehydrogenase activity
P40_15760	COG0583	DNA-binding transcription factor activity
P40_15765	COG2814	Major facilitator Superfamily
P40_15775	COG2249	NAD(P)H dehydrogenase (quinone) activity
P40_15780	COG0583	DNA-binding transcription factor activity
P40_15820	COG0183	Belongs to the thiolase family
P40_15830	COG4993	Dehydrogenase
P40_15855	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
P40_15865	COG0318	PFAM AMP-dependent synthetase and ligase
P40_15880	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
P40_15885	COG1191	sigma factor activity
P40_15905	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
P40_15920	COG0745	RESPONSE REGULATOR receiver
P40_15925	COG0840	transmembrane signaling receptor activity
P40_15930	COG2201	protein-glutamate methylesterase activity
P40_15935	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
P40_15940	COG0840	transmembrane signaling receptor activity
P40_15950	COG0835	chemotaxis
P40_15960	COG1360	Flagellar Motor Protein
P40_15980	COG2257	FlhB HrpN YscU SpaS Family
P40_16035	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
P40_16060	COG1580	Controls the rotational direction of flagella during chemotaxis
P40_16065	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
P40_16085	COG1987	bacterial-type flagellum assembly
P40_16095	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
P40_16100	COG1256	bacterial-type flagellum assembly
P40_16105	COG1705	Flagellar rod assembly protein muramidase FlgJ
P40_16105	COG3951	Flagellar rod assembly protein muramidase FlgJ
P40_16110	COG1706	bacterial-type flagellum-dependent cell motility
P40_16120	COG4786	Flagellar basal body rod
P40_16130	COG1749	Flagellar hook protein flgE
P40_16135	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
P40_16140	COG1558	bacterial-type flagellum-dependent cell motility
P40_16165	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
P40_16190	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
P40_16210	COG3119	arylsulfatase activity
P40_16220	COG4585	Histidine kinase
P40_16225	COG0745	RESPONSE REGULATOR receiver
P40_16250	COG0583	DNA-binding transcription factor activity
P40_16255	COG0459	protein refolding
P40_16260	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
P40_16270	COG2211	Major facilitator Superfamily
P40_16275	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
P40_16280	COG2096	Adenosyltransferase
P40_16285	COG2205	protein histidine kinase activity
P40_16290	COG0745	RESPONSE REGULATOR receiver
P40_16325	COG1115	amino acid carrier protein
P40_16375	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
P40_16380	COG0237	dephospho-CoA kinase activity
P40_16385	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
P40_16395	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
P40_16400	COG0653	protein targeting
P40_16405	COG0739	heme binding
P40_16415	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
P40_16430	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
P40_16435	COG1181	Belongs to the D-alanine--D-alanine ligase family
P40_16440	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
P40_16445	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
P40_16450	COG0772	Belongs to the SEDS family
P40_16455	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
P40_16460	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
P40_16465	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
P40_16470	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
P40_16485	COG0275	rRNA processing
P40_16490	COG2001	Belongs to the MraZ family
P40_16500	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
P40_16510	COG0792	nuclease activity
P40_16520	COG2823	Periplasmic or secreted lipoprotein
P40_16525	COG0318	PFAM AMP-dependent synthetase and ligase
P40_16530	COG1028	Short-chain dehydrogenase reductase Sdr
P40_16540	COG3119	arylsulfatase activity
P40_16545	COG2969	positive regulation of protein catabolic process
P40_16550	COG0625	glutathione transferase activity
P40_16555	COG2857	Cytochrome c1
P40_16560	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
P40_16565	COG0723	plastoquinol--plastocyanin reductase activity
P40_16570	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
P40_16575	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
P40_16580	COG0667	Aldo Keto reductase
P40_16585	COG1309	transcriptional regulator
P40_16600	COG1802	Transcriptional regulator
P40_16610	COG0559	Belongs to the binding-protein-dependent transport system permease family
P40_16620	COG0411	ABC transporter
P40_16635	COG1960	acyl-CoA dehydrogenase activity
P40_16670	COG2801	Transposase and inactivated derivatives
P40_16695	COG2067	long-chain fatty acid transport protein
P40_16700	COG1960	acyl-CoA dehydrogenase activity
P40_16705	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
P40_16710	COG2945	thiolester hydrolase activity
P40_16720	COG2046	Belongs to the sulfate adenylyltransferase family
P40_16725	COG1597	lipid kinase activity
P40_16735	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
P40_16745	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
P40_16750	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
P40_16755	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
P40_16760	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
P40_16765	COG5007	Belongs to the BolA IbaG family
P40_16785	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
P40_16800	COG1137	ATPase activity
P40_16805	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
P40_16820	COG1660	Displays ATPase and GTPase activities
P40_16835	COG0443	Heat shock 70 kDa protein
P40_16845	COG0312	modulator of DNA gyrase
P40_16850	COG3028	Belongs to the UPF0307 family
P40_16855	COG2807	transmembrane transport
P40_16860	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
P40_16860	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
P40_16865	COG0312	modulator of DNA gyrase
P40_16870	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
P40_16880	COG0424	maF-like protein
P40_16885	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
P40_16890	COG1792	Involved in formation and maintenance of cell shape
P40_16895	COG1077	Cell shape determining protein MreB Mrl
P40_16900	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
P40_16905	COG0154	amidase activity
P40_16910	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
P40_16925	COG1024	Enoyl-CoA hydratase
P40_17005	COG3038	cytochrome b561
P40_17020	COG2205	protein histidine kinase activity
P40_17025	COG2197	response regulator
P40_17040	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
P40_17045	COG2890	protein-(glutamine-N5) methyltransferase activity
P40_17050	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
P40_17055	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
P40_17065	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
P40_17070	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
P40_17080	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
P40_17085	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
P40_17090	COG0193	aminoacyl-tRNA hydrolase activity
P40_17100	COG0012	GTP binding
P40_17110	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
P40_17190	COG1045	serine acetyltransferase
P40_17195	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
P40_17205	COG1012	belongs to the aldehyde dehydrogenase family
P40_17210	COG0473	3-isopropylmalate dehydrogenase activity
P40_17225	COG0154	amidase activity
P40_17230	COG0436	Aminotransferase
P40_17240	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
P40_17245	COG1862	Preprotein translocase
P40_17250	COG0343	queuine tRNA-ribosyltransferase activity
P40_17255	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
P40_17280	COG1192	Involved in chromosome partitioning
P40_17550	COG4115	mRNA cleavage
P40_17555	COG2161	toxin-antitoxin pair type II binding
P40_17570	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
P40_17590	COG3501	Rhs element vgr protein
P40_17690	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
P40_17700	COG0795	lipopolysaccharide-transporting ATPase activity
P40_17705	COG0795	lipopolysaccharide-transporting ATPase activity
P40_17710	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
P40_17720	COG0525	valine-tRNA ligase activity
P40_17735	COG1597	lipid kinase activity
P40_17765	COG1183	phosphatidylcholine synthase activity
P40_17770	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
P40_17775	COG0583	DNA-binding transcription factor activity
P40_17785	COG0318	PFAM AMP-dependent synthetase and ligase
P40_17795	COG1280	lysine exporter protein (LysE YggA)
P40_17805	COG0028	Belongs to the TPP enzyme family
P40_17900	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
P40_17905	COG1047	Peptidyl-prolyl cis-trans
P40_17910	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
P40_17915	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
P40_17920	COG0196	riboflavin kinase activity
P40_17925	COG0728	peptidoglycan biosynthetic process
P40_17930	COG0268	Binds directly to 16S ribosomal RNA
P40_17935	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
P40_17940	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
P40_17945	COG0211	Belongs to the bacterial ribosomal protein bL27 family
P40_17950	COG0261	This protein binds to 23S rRNA in the presence of protein L20
P40_17955	COG0142	geranyltranstransferase activity
P40_17990	COG1028	Short-chain dehydrogenase reductase Sdr
P40_18025	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
P40_18040	COG4221	oxidoreductase activity
P40_18045	COG2267	carboxylic ester hydrolase activity
P40_18080	COG2814	Major facilitator Superfamily
P40_18115	COG0659	secondary active sulfate transmembrane transporter activity
P40_18125	COG0203	ribosomal protein L17
P40_18130	COG0202	RNA polymerase activity
P40_18135	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
P40_18140	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
P40_18145	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
P40_18150	COG0257	Belongs to the bacterial ribosomal protein bL36 family
P40_18160	COG0200	Binds to the 23S rRNA
P40_18165	COG1841	ribosomal large subunit assembly
P40_18170	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
P40_18175	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
P40_18180	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
P40_18185	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
P40_18190	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
P40_18195	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
P40_18200	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
P40_18205	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
P40_18210	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
P40_18215	COG0255	Belongs to the universal ribosomal protein uL29 family
P40_18220	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
P40_18225	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
P40_18230	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
P40_18235	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
P40_18240	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
P40_18245	COG0089	rRNA binding
P40_18250	COG0088	Forms part of the polypeptide exit tunnel
P40_18255	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
P40_18260	COG0051	transcription antitermination factor activity, RNA binding
P40_18265	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
P40_18270	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
P40_18275	COG0049	tRNA binding
P40_18280	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
P40_18285	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
P40_18290	COG0085	RNA polymerase activity
P40_18295	COG0222	ribosome binding
P40_18300	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
P40_18305	COG0081	regulation of translation
P40_18310	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
P40_18330	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
P40_18360	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
P40_18400	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
P40_18405	COG0739	heme binding
P40_18410	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
P40_18420	COG0316	Belongs to the HesB IscA family
P40_18445	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
P40_18445	COG0352	thiamine-phosphate diphosphorylase activity
P40_18445	COG0351	phosphomethylpyrimidine kinase
P40_18450	COG0352	thiamine-phosphate diphosphorylase activity
P40_18455	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
P40_18470	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
P40_18475	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
P40_18490	COG1489	DNA binding
P40_18495	COG0436	Aminotransferase
P40_18505	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
P40_18510	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
P40_18530	COG0617	tRNA 3'-terminal CCA addition
P40_18540	COG1428	Deoxynucleoside kinase
P40_18545	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
P40_18550	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
P40_18555	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
P40_18560	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
P40_18570	COG2814	Major facilitator Superfamily
P40_18590	COG1024	Enoyl-CoA hydratase
P40_18615	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
P40_18625	COG2186	Transcriptional regulator
P40_18640	COG3344	reverse transcriptase
P40_18645	COG1185	polyribonucleotide nucleotidyltransferase activity
P40_18650	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
P40_18660	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
P40_18665	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
P40_18670	COG0195	Participates in both transcription termination and antitermination
P40_18670	COG2251	uridine kinase activity
P40_18675	COG0779	Required for maturation of 30S ribosomal subunits
P40_18695	COG0149	triose-phosphate isomerase activity
P40_18700	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
P40_18705	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
P40_18710	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
P40_18715	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
P40_18725	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
P40_18735	COG0505	Belongs to the CarA family
P40_18740	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
P40_18745	COG0484	heat shock protein binding
P40_18750	COG0443	Heat shock 70 kDa protein
P40_18755	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
P40_18760	COG1420	regulation of RNA biosynthetic process
P40_18765	COG0497	DNA recombination
P40_18780	COG2914	Belongs to the UPF0125 (RnfH) family
P40_18785	COG0733	neurotransmitter:sodium symporter activity
P40_18790	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
P40_18850	COG0395	ABC-type sugar transport system, permease component
P40_18860	COG1653	transport
P40_18880	COG1012	belongs to the aldehyde dehydrogenase family
P40_18895	COG0667	Aldo Keto reductase
P40_18900	COG1028	Short-chain dehydrogenase reductase Sdr
P40_18905	COG0583	DNA-binding transcription factor activity
P40_18930	COG0154	amidase activity
P40_18960	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
P40_18995	COG2807	transmembrane transport
P40_19010	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
P40_19015	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
P40_19025	COG0402	S-adenosylhomocysteine deaminase activity
P40_19030	COG3195	allantoin biosynthetic process
P40_19030	COG3648	Uricase
P40_19050	COG4266	Belongs to the allantoicase family
P40_19055	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
P40_19070	COG0583	DNA-binding transcription factor activity
P40_19095	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
P40_19100	COG0590	tRNA wobble adenosine to inosine editing
P40_19100	COG0037	tRNA processing
P40_19120	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
P40_19130	COG0505	Belongs to the CarA family
P40_19140	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
P40_19145	COG1522	sequence-specific DNA binding
P40_19150	COG2423	ornithine cyclodeaminase activity
P40_19175	COG1960	acyl-CoA dehydrogenase activity
P40_19180	COG1028	Short-chain dehydrogenase reductase Sdr
P40_19190	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
P40_19210	COG0559	Belongs to the binding-protein-dependent transport system permease family
P40_19240	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
P40_19245	COG2226	methyltransferase
P40_19250	COG0596	Alpha beta hydrolase
P40_19255	COG0156	8-amino-7-oxononanoate synthase activity
P40_19260	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
P40_19265	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
P40_19270	COG2045	Belongs to the ComB family
P40_19290	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
P40_19295	COG0493	'glutamate synthase
P40_19300	COG0070	glutamate synthase
P40_19300	COG0069	glutamate synthase activity
P40_19300	COG0067	glutamate synthase
P40_19310	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
P40_19315	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
P40_19360	COG0281	malic enzyme
P40_19365	COG0254	rRNA binding
P40_19370	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
P40_19375	COG0477	Major facilitator Superfamily
P40_19380	COG1566	PFAM secretion protein HlyD family protein
P40_19385	COG0018	arginyl-trna synthetase
P40_19395	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
P40_19400	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
P40_19405	COG0129	dihydroxy-acid dehydratase activity
P40_19420	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
P40_19420	COG0543	2 iron, 2 sulfur cluster binding
P40_19425	COG2995	paraquat-inducible protein a
P40_19430	COG3008	intermembrane lipid transfer
P40_19430	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
P40_19455	COG0181	hydroxymethylbilane synthase activity
P40_19465	COG3275	phosphorelay sensor kinase activity
P40_19470	COG0165	Argininosuccinate lyase
P40_19480	COG0534	Mate efflux family protein
P40_19500	COG4774	siderophore transport
P40_19510	COG1595	DNA-templated transcription, initiation
P40_19530	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
P40_19535	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
P40_19545	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
P40_19550	COG2267	carboxylic ester hydrolase activity
P40_19565	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
P40_19575	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
P40_19585	COG3098	single-species biofilm formation
P40_19590	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
P40_19600	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
P40_19610	COG4774	siderophore transport
P40_19620	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
P40_19625	COG0248	Ppx GppA phosphatase
P40_19640	COG1335	isochorismatase
P40_19645	COG0583	DNA-binding transcription factor activity
P40_19655	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
P40_19680	COG2205	protein histidine kinase activity
P40_19685	COG0745	RESPONSE REGULATOR receiver
P40_19690	COG3268	Saccharopine dehydrogenase
P40_19710	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
P40_19715	COG2186	Transcriptional regulator
P40_19720	COG0154	amidase activity
P40_19725	COG0604	alcohol dehydrogenase
P40_19730	COG0318	PFAM AMP-dependent synthetase and ligase
P40_19745	COG4247	3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase)
P40_19770	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
P40_19775	COG1595	DNA-templated transcription, initiation
P40_19805	COG3530	Putative quorum-sensing-regulated virulence factor
P40_19820	COG0789	Transcriptional regulator
P40_19825	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
P40_19830	COG3384	dioxygenase
P40_19840	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
P40_19860	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
P40_19885	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
P40_19885	COG2169	Transcriptional regulator
P40_19935	COG0450	alkyl hydroperoxide reductase
P40_19940	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
P40_19945	COG4208	sulfate ABC transporter
P40_19955	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
P40_19975	COG0840	transmembrane signaling receptor activity
P40_19985	COG2132	Multicopper oxidase
P40_20000	COG0288	reversible hydration of carbon dioxide
P40_20005	COG1047	Peptidyl-prolyl cis-trans
P40_20015	COG0583	DNA-binding transcription factor activity
P40_20040	COG0318	PFAM AMP-dependent synthetase and ligase
P40_20050	COG1012	belongs to the aldehyde dehydrogenase family
P40_20055	COG1960	acyl-CoA dehydrogenase activity
P40_20060	COG1028	Short-chain dehydrogenase reductase Sdr
P40_20070	COG2030	dehydratase
P40_20080	COG4191	Histidine kinase
P40_20085	COG4566	intracellular signal transduction
P40_20100	COG1959	2 iron, 2 sulfur cluster binding
P40_20110	COG1492	cobalamin metabolic process
P40_20120	COG1797	cobyrinic acid a,c-diamide synthase activity
P40_20125	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
P40_20130	COG4139	cobalamin transport
P40_20135	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
P40_20140	COG4206	TonB-dependent receptor
P40_20165	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
P40_20180	COG0642	Histidine kinase
P40_20220	COG1804	L-carnitine dehydratase bile acid-inducible protein F
P40_20225	COG1028	Short-chain dehydrogenase reductase Sdr
P40_20230	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
P40_20240	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
P40_20250	COG1028	Short-chain dehydrogenase reductase Sdr
P40_20255	COG0583	DNA-binding transcription factor activity
P40_20260	COG0432	Pfam Uncharacterised protein family UPF0047
P40_20265	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
P40_20275	COG1012	belongs to the aldehyde dehydrogenase family
P40_20285	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
P40_20295	COG1166	arginine decarboxylase activity
P40_20305	COG2814	Major facilitator Superfamily
P40_20315	COG4221	oxidoreductase activity
P40_20320	COG1733	regulation of RNA biosynthetic process
P40_20340	COG0004	ammonium transporteR
P40_20345	COG0347	Belongs to the P(II) protein family
P40_20350	COG2960	long-chain fatty acid transporting porin activity
P40_20355	COG2015	COG2015, Alkyl sulfatase and related hydrolases
P40_20370	COG0697	spore germination
P40_20380	COG1028	Short-chain dehydrogenase reductase Sdr
P40_20390	COG1187	pseudouridine synthase activity
P40_20405	COG5002	protein histidine kinase activity
P40_20415	COG0745	RESPONSE REGULATOR receiver
P40_20435	COG1960	acyl-CoA dehydrogenase activity
P40_20440	COG1960	acyl-CoA dehydrogenase activity
P40_20455	COG0318	PFAM AMP-dependent synthetase and ligase
P40_20460	COG0318	PFAM AMP-dependent synthetase and ligase
P40_20475	COG0318	PFAM AMP-dependent synthetase and ligase
P40_20480	COG0183	Belongs to the thiolase family
P40_20490	COG2909	trisaccharide binding
P40_20500	COG1024	Enoyl-CoA hydratase
P40_20505	COG1028	Short-chain dehydrogenase reductase Sdr
P40_20515	COG1804	L-carnitine dehydratase bile acid-inducible protein F
P40_20525	COG1024	Enoyl-CoA hydratase
P40_20530	COG1960	acyl-CoA dehydrogenase activity
P40_20545	COG1024	Enoyl-CoA hydratase
P40_20570	COG1280	lysine exporter protein (LysE YggA)
P40_20580	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
P40_20615	COG1515	deoxyribonuclease V activity
P40_20670	COG2353	YceI-like domain
P40_20675	COG3038	cytochrome b561
P40_20685	COG1028	Short-chain dehydrogenase reductase Sdr
P40_20690	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
P40_20695	COG0385	Bile acid
P40_20700	COG0492	ferredoxin-NADP+ reductase activity
P40_20715	COG1024	Enoyl-CoA hydratase
P40_20730	COG1125	glycine betaine transport
P40_20730	COG0517	IMP dehydrogenase activity
P40_20760	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
P40_20760	COG0678	peroxiredoxin activity
P40_20775	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
P40_20785	COG0753	catalase activity
P40_20790	COG1272	protein, Hemolysin III
P40_20800	COG0386	Belongs to the glutathione peroxidase family
P40_20830	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
P40_20875	COG0218	Necessary for normal cell division and for the maintenance of normal septation
P40_20885	COG2212	antiporter activity
P40_20890	COG1863	multisubunit Na H antiporter MnhE subunit
P40_20895	COG0651	ATP synthesis coupled electron transport
P40_20900	COG1006	Multisubunit Na H antiporter MnhC subunit
P40_20905	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
P40_20905	COG2111	Na H antiporter
P40_20920	COG1160	GTP binding
P40_20930	COG2610	gluconate transmembrane transporter activity
P40_20940	COG1960	acyl-CoA dehydrogenase activity
P40_20945	COG1024	Enoyl-CoA hydratase
P40_20945	COG1250	3-hydroxyacyl-CoA dehydrogenase
P40_20965	COG5285	phytanoyl-CoA dioxygenase
P40_20970	COG1028	Short-chain dehydrogenase reductase Sdr
P40_21015	COG1131	(ABC) transporter
P40_21020	COG0842	Transport permease protein
P40_21040	COG0625	glutathione transferase activity
P40_21045	COG0668	transmembrane transport
P40_21050	COG0678	peroxiredoxin activity
P40_21065	COG1666	GTP binding
P40_21075	COG3093	addiction module antidote protein HigA
P40_21080	COG1901	pseudouridine methyltransferase
P40_21110	COG1121	(ABC) transporter
P40_21115	COG1108	ABC-type Mn2 Zn2 transport systems permease components
P40_21120	COG0534	Mate efflux family protein
P40_21175	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
P40_21180	COG1773	rubredoxin
P40_21185	COG3161	chorismate lyase activity
P40_21190	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
P40_21205	COG2900	Belongs to the SlyX family
P40_21210	COG1309	transcriptional regulator
P40_21220	COG2119	membrane
P40_21225	COG4681	YaeQ
P40_21235	COG0431	NADPH-dependent FMN reductase
P40_21240	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
P40_21245	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
P40_21250	COG0640	Transcriptional regulator
P40_21260	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
P40_21265	COG0581	inorganic phosphate transmembrane transporter activity
P40_21270	COG0573	inorganic phosphate transmembrane transporter activity
P40_21275	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
P40_21290	COG1607	acyl-coa hydrolase
P40_21295	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
P40_21300	COG0210	DNA helicase
P40_21320	COG3284	Transcriptional regulator
P40_21335	COG1012	belongs to the aldehyde dehydrogenase family
P40_21370	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
P40_21375	COG0601	transmembrane transport
P40_21380	COG0747	negative chemotaxis
P40_21395	COG1960	acyl-CoA dehydrogenase activity
P40_21400	COG1309	transcriptional regulator
P40_21425	COG0824	Thioesterase
P40_21430	COG0318	PFAM AMP-dependent synthetase and ligase
P40_21435	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
P40_21440	COG1970	mechanosensitive ion channel activity
P40_21445	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
P40_21445	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
P40_21450	COG0737	Belongs to the 5'-nucleotidase family
P40_21460	COG0583	DNA-binding transcription factor activity
P40_21475	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
P40_21485	COG0559	Belongs to the binding-protein-dependent transport system permease family
P40_21490	COG0559	Belongs to the binding-protein-dependent transport system permease family
P40_21525	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
P40_21530	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
P40_21535	COG0355	proton-transporting ATP synthase activity, rotational mechanism
P40_21540	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
P40_21545	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
P40_21550	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
P40_21555	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
P40_21560	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
P40_21570	COG0356	it plays a direct role in the translocation of protons across the membrane
P40_21580	COG1475	DNA binding
P40_21585	COG1192	Involved in chromosome partitioning
P40_21590	COG0357	Ribosomal RNA small subunit methyltransferase G
P40_21595	COG0445	tRNA wobble uridine modification
P40_21600	COG3263	regulation of cellular component size
P40_21605	COG0300	oxidoreductase activity
P40_21615	COG1960	acyl-CoA dehydrogenase activity
P40_21620	COG0546	phosphoglycolate phosphatase activity
P40_21630	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
P40_21635	COG1278	Cold shock
P40_21655	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
P40_21660	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
P40_21665	COG0318	PFAM AMP-dependent synthetase and ligase
P40_21685	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
P40_21690	COG0706	membrane insertase activity
P40_21695	COG0594	ribonuclease P activity
P40_21700	COG0230	Belongs to the bacterial ribosomal protein bL34 family