locus-tag	class	description
GO499_00015	COG0277	FAD linked oxidase domain protein
GO499_00035	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
GO499_00040	COG3920	Histidine kinase
GO499_00060	COG1192	Involved in chromosome partitioning
GO499_00070	COG4953	penicillin-binding protein 1C
GO499_00130	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GO499_00140	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
GO499_00145	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
GO499_00155	COG0071	Belongs to the small heat shock protein (HSP20) family
GO499_00165	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
GO499_00175	COG1764	response to oxidative stress
GO499_00185	COG0492	ferredoxin-NADP+ reductase activity
GO499_00190	COG1522	sequence-specific DNA binding
GO499_00205	COG0006	proline dipeptidase activity
GO499_00220	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
GO499_00240	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GO499_00250	COG1435	thymidine kinase activity
GO499_00260	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
GO499_00275	COG0110	maltose O-acetyltransferase activity
GO499_00280	COG0625	glutathione transferase activity
GO499_00285	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
GO499_00290	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
GO499_00295	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
GO499_00305	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
GO499_00310	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
GO499_00350	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
GO499_00375	COG0330	HflC and HflK could
GO499_00390	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
GO499_00400	COG0697	spore germination
GO499_00425	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GO499_00450	COG0137	argininosuccinate synthase activity
GO499_00460	COG1454	alcohol dehydrogenase
GO499_00485	COG0183	Belongs to the thiolase family
GO499_00490	COG3706	GGDEF domain
GO499_00500	COG0435	Glutathione S-transferase
GO499_00510	COG4948	Mandelate Racemase Muconate Lactonizing
GO499_00540	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
GO499_00545	COG0009	L-threonylcarbamoyladenylate synthase
GO499_00550	COG1960	acyl-CoA dehydrogenase activity
GO499_00580	COG0828	Belongs to the bacterial ribosomal protein bS21 family
GO499_00620	COG1028	Short-chain dehydrogenase reductase Sdr
GO499_00625	COG2813	Specifically methylates the guanine in position
GO499_00630	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
GO499_00640	COG1686	Belongs to the peptidase S11 family
GO499_00645	COG1192	Involved in chromosome partitioning
GO499_00650	COG0254	rRNA binding
GO499_00660	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
GO499_00665	COG0049	tRNA binding
GO499_00670	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GO499_00680	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
GO499_00685	COG0051	transcription antitermination factor activity, RNA binding
GO499_00690	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
GO499_00695	COG0088	Forms part of the polypeptide exit tunnel
GO499_00700	COG0089	rRNA binding
GO499_00705	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
GO499_00710	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
GO499_00715	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
GO499_00720	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
GO499_00735	COG0255	Belongs to the universal ribosomal protein uL29 family
GO499_00740	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
GO499_00745	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
GO499_00750	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
GO499_00755	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
GO499_00760	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
GO499_00765	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
GO499_00770	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
GO499_00775	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
GO499_00780	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
GO499_00785	COG1841	ribosomal large subunit assembly
GO499_00795	COG0200	Binds to the 23S rRNA
GO499_00800	COG0201	protein transport
GO499_00805	COG0563	adenylate kinase activity
GO499_00815	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
GO499_00820	COG0202	RNA polymerase activity
GO499_00825	COG0203	ribosomal protein L17
GO499_00830	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
GO499_00845	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
GO499_00850	COG0564	pseudouridine synthase activity
GO499_00865	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GO499_00870	COG4597	amino acid ABC transporter
GO499_00875	COG0765	amino acid transport
GO499_00880	COG1126	abc transporter atp-binding protein
GO499_00885	COG2062	phosphohistidine phosphatase, SixA
GO499_00910	COG1283	sodium-dependent phosphate transmembrane transporter activity
GO499_00935	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GO499_00940	COG0601	transmembrane transport
GO499_00945	COG0747	negative chemotaxis
GO499_00955	COG4172	Belongs to the ABC transporter superfamily
GO499_00965	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
GO499_00970	COG1999	signal sequence binding
GO499_01015	COG1804	L-carnitine dehydratase bile acid-inducible protein F
GO499_01030	COG1414	Transcriptional regulator
GO499_01035	COG0402	S-adenosylhomocysteine deaminase activity
GO499_01070	COG3485	protocatechuate 3,4-dioxygenase
GO499_01075	COG3485	protocatechuate 3,4-dioxygenase
GO499_01080	COG0251	oxidation-reduction process
GO499_01090	COG1116	anion transmembrane transporter activity
GO499_01095	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GO499_01100	COG0402	S-adenosylhomocysteine deaminase activity
GO499_01105	COG0812	UDP-N-acetylmuramate dehydrogenase activity
GO499_01110	COG2249	NAD(P)H dehydrogenase (quinone) activity
GO499_01115	COG2249	NAD(P)H dehydrogenase (quinone) activity
GO499_01125	COG0300	oxidoreductase activity
GO499_01135	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
GO499_01160	COG0714	Associated with various cellular activities
GO499_01175	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GO499_01180	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
GO499_01185	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GO499_01185	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GO499_01210	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GO499_01210	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GO499_01215	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
GO499_01225	COG0432	Pfam Uncharacterised protein family UPF0047
GO499_01250	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GO499_01275	COG0564	pseudouridine synthase activity
GO499_01290	COG2205	protein histidine kinase activity
GO499_01310	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
GO499_01335	COG4172	Belongs to the ABC transporter superfamily
GO499_01340	COG4239	(ABC) transporter, permease
GO499_01345	COG4174	ABC transporter (Permease)
GO499_01350	COG4166	transmembrane transport
GO499_01355	COG3474	cytochrome
GO499_01365	COG0840	transmembrane signaling receptor activity
GO499_01400	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
GO499_01425	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
GO499_01435	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
GO499_01440	COG0697	spore germination
GO499_01455	COG1653	transport
GO499_01460	COG1175	transmembrane transport
GO499_01465	COG0395	ABC-type sugar transport system, permease component
GO499_01470	COG3842	ATPase activity
GO499_01485	COG0673	inositol 2-dehydrogenase activity
GO499_01490	COG0667	Aldo Keto reductase
GO499_01510	COG0227	Belongs to the bacterial ribosomal protein bL28 family
GO499_01515	COG1703	isobutyryl-CoA mutase activity
GO499_01525	COG1643	Atp-dependent helicase
GO499_01530	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
GO499_01550	COG1741	Belongs to the pirin family
GO499_01585	COG4948	Mandelate Racemase Muconate Lactonizing
GO499_01600	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
GO499_01615	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
GO499_01620	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
GO499_01635	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
GO499_01645	COG0300	oxidoreductase activity
GO499_01655	COG5598	trimethylamine methyltransferase
GO499_01680	COG1309	transcriptional regulator
GO499_01690	COG2818	Glycosylase
GO499_01720	COG0267	Belongs to the bacterial ribosomal protein bL33 family
GO499_01750	COG1396	sequence-specific DNA binding
GO499_01750	COG3800	Transcriptional regulator
GO499_01755	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GO499_01775	COG4770	biotin carboxylase activity
GO499_01785	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
GO499_01785	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
GO499_01790	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
GO499_01800	COG0280	phosphate acetyltransferase
GO499_01800	COG0281	malic enzyme
GO499_01815	COG0346	lactoylglutathione lyase activity
GO499_01825	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
GO499_01830	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
GO499_01835	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
GO499_01840	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
GO499_01845	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
GO499_01875	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
GO499_01880	COG0737	Belongs to the 5'-nucleotidase family
GO499_01900	COG3853	Toxic anion resistance protein (TelA)
GO499_01910	COG1253	flavin adenine dinucleotide binding
GO499_01915	COG1278	Cold shock
GO499_01925	COG0154	amidase activity
GO499_01940	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
GO499_01945	COG0590	tRNA wobble adenosine to inosine editing
GO499_01950	COG1187	pseudouridine synthase activity
GO499_01955	COG3023	N-Acetylmuramoyl-L-alanine amidase
GO499_01970	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
GO499_01980	COG2001	Belongs to the MraZ family
GO499_01985	COG0275	rRNA processing
GO499_02000	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
GO499_02010	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GO499_02035	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
GO499_02040	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GO499_02055	COG0812	UDP-N-acetylmuramate dehydrogenase activity
GO499_02060	COG1181	Belongs to the D-alanine--D-alanine ligase family
GO499_02065	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
GO499_02070	COG0849	cell division
GO499_02075	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
GO499_02085	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GO499_02100	COG0277	FAD linked oxidase domain protein
GO499_02140	COG0697	spore germination
GO499_02165	COG2244	polysaccharide biosynthetic process
GO499_02195	COG0673	inositol 2-dehydrogenase activity
GO499_02205	COG0662	Cupin 2, conserved barrel domain protein
GO499_02205	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
GO499_02220	COG3267	Type II secretory pathway component ExeA
GO499_02220	COG3409	Peptidoglycan-binding domain 1 protein
GO499_02235	COG1028	Short-chain dehydrogenase reductase Sdr
GO499_02245	COG1216	Glycosyl transferase, family 2
GO499_02255	COG1091	dTDP-4-dehydrorhamnose reductase activity
GO499_02265	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
GO499_02295	COG0438	transferase activity, transferring glycosyl groups
GO499_02345	COG1028	Short-chain dehydrogenase reductase Sdr
GO499_02350	COG0308	aminopeptidase N
GO499_02395	COG0481	GTPase activity
GO499_02405	COG0481	GTPase activity
GO499_02435	COG0519	Catalyzes the synthesis of GMP from XMP
GO499_02440	COG0513	Belongs to the DEAD box helicase family
GO499_02445	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
GO499_02460	COG1959	2 iron, 2 sulfur cluster binding
GO499_02470	COG2873	o-acetylhomoserine
GO499_02485	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GO499_02500	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
GO499_02505	COG1960	acyl-CoA dehydrogenase activity
GO499_02515	COG1793	dna ligase
GO499_02565	COG3135	benzoate transporter
GO499_02580	COG1176	ABC-type spermidine putrescine transport system, permease component I
GO499_02595	COG3842	ATPase activity
GO499_02605	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GO499_02610	COG0444	Belongs to the ABC transporter superfamily
GO499_02615	COG4608	Belongs to the ABC transporter superfamily
GO499_02625	COG0601	transmembrane transport
GO499_02630	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GO499_02635	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GO499_02640	COG4133	protoheme IX ABC transporter activity
GO499_02665	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
GO499_02675	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
GO499_02700	COG3750	Belongs to the UPF0335 family
GO499_02710	COG0058	SHG alpha-glucan phosphorylase activity
GO499_02720	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
GO499_02725	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
GO499_02730	COG0297	glycogen (starch) synthase activity
GO499_02740	COG0033	Phosphoglucomutase
GO499_02750	COG0527	aspartate kinase activity
GO499_02755	COG1917	Cupin 2, conserved barrel domain protein
GO499_02760	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
GO499_02770	COG1846	Transcriptional regulator
GO499_02800	COG2759	Belongs to the formate--tetrahydrofolate ligase family
GO499_02805	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
GO499_02810	COG1804	L-carnitine dehydratase bile acid-inducible protein F
GO499_02825	COG0045	succinate-CoA ligase (ADP-forming) activity
GO499_02830	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
GO499_02850	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
GO499_02880	COG1309	transcriptional regulator
GO499_02895	COG1309	transcriptional regulator
GO499_02905	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
GO499_02925	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GO499_02930	COG0789	Transcriptional regulator
GO499_02970	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GO499_02975	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GO499_03020	COG2234	aminopeptidase activity
GO499_03035	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
GO499_03040	COG1473	amidohydrolase
GO499_03050	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GO499_03055	COG1595	DNA-templated transcription, initiation
GO499_03065	COG0129	dihydroxy-acid dehydratase activity
GO499_03070	COG4214	carbohydrate transport
GO499_03080	COG4213	ABC transporter substrate-binding protein
GO499_03105	COG0559	Belongs to the binding-protein-dependent transport system permease family
GO499_03135	COG0542	response to heat
GO499_03145	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GO499_03170	COG0316	Belongs to the HesB IscA family
GO499_03175	COG0232	Belongs to the dGTPase family. Type 2 subfamily
GO499_03180	COG0018	arginyl-trna synthetase
GO499_03190	COG1472	Belongs to the glycosyl hydrolase 3 family
GO499_03195	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
GO499_03200	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
GO499_03205	COG0717	Belongs to the dCTP deaminase family
GO499_03220	COG0776	regulation of translation
GO499_03225	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GO499_03230	COG0416	fatty acid biosynthetic process
GO499_03235	COG0333	Belongs to the bacterial ribosomal protein bL32 family
GO499_03240	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
GO499_03255	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GO499_03270	COG0625	glutathione transferase activity
GO499_03285	COG0302	gtp cyclohydrolase
GO499_03290	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GO499_03295	COG0752	glycyl-tRNA synthetase alpha subunit
GO499_03315	COG2066	Belongs to the glutaminase family
GO499_03320	COG0751	glycine-tRNA ligase activity
GO499_03325	COG0574	Belongs to the PEP-utilizing enzyme family
GO499_03325	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GO499_03330	COG3409	Peptidoglycan-binding domain 1 protein
GO499_03330	COG3773	Cell wall hydrolase
GO499_03335	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
GO499_03345	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
GO499_03350	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GO499_03375	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
GO499_03380	COG2084	Dehydrogenase
GO499_03395	COG0395	ABC-type sugar transport system, permease component
GO499_03415	COG1802	Transcriptional regulator
GO499_03420	COG3842	ATPase activity
GO499_03435	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GO499_03440	COG0840	transmembrane signaling receptor activity
GO499_03505	COG2124	cytochrome p450
GO499_03515	COG3386	PFAM SMP-30 Gluconolaconase
GO499_03530	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
GO499_03545	COG2205	protein histidine kinase activity
GO499_03560	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
GO499_03565	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
GO499_03570	COG0535	radical SAM domain protein
GO499_03575	COG0535	radical SAM domain protein
GO499_03580	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GO499_03590	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GO499_03600	COG3383	formate dehydrogenase (NAD+) activity
GO499_03605	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
GO499_03610	COG4251	negative regulation of phosphorylation
GO499_03630	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
GO499_03635	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GO499_03640	COG1028	Short-chain dehydrogenase reductase Sdr
GO499_03650	COG1486	melibiose metabolic process
GO499_03655	COG1175	transmembrane transport
GO499_03660	COG0395	ABC-type sugar transport system, permease component
GO499_03665	COG3842	ATPase activity
GO499_03680	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
GO499_03685	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GO499_03710	COG2144	transferase activity, transferring acyl groups
GO499_03740	COG0045	succinate-CoA ligase (ADP-forming) activity
GO499_03745	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
GO499_03750	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GO499_03755	COG1609	Transcriptional regulator
GO499_03765	COG1175	transmembrane transport
GO499_03780	COG1028	Short-chain dehydrogenase reductase Sdr
GO499_03800	COG0154	amidase activity
GO499_03810	COG1177	transmembrane transport
GO499_03815	COG1176	ABC-type spermidine putrescine transport system, permease component I
GO499_03820	COG3842	ATPase activity
GO499_03830	COG1802	Transcriptional regulator
GO499_03845	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GO499_03850	COG4608	Belongs to the ABC transporter superfamily
GO499_03855	COG0444	Belongs to the ABC transporter superfamily
GO499_03860	COG0154	amidase activity
GO499_03885	COG1879	ABC-type sugar transport system periplasmic component
GO499_03890	COG1129	ABC transporter
GO499_03895	COG1172	Belongs to the binding-protein-dependent transport system permease family
GO499_03900	COG1172	Belongs to the binding-protein-dependent transport system permease family
GO499_03905	COG2186	Transcriptional regulator
GO499_03915	COG1294	oxidase, subunit
GO499_03920	COG1271	oxidase subunit
GO499_03930	COG1028	Short-chain dehydrogenase reductase Sdr
GO499_03930	COG0318	PFAM AMP-dependent synthetase and ligase
GO499_03930	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GO499_03930	COG3321	synthase
GO499_03930	COG0300	oxidoreductase activity
GO499_03935	COG1024	Enoyl-CoA hydratase
GO499_03950	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
GO499_03965	COG1960	acyl-CoA dehydrogenase activity
GO499_03970	COG1049	propionate catabolic process, 2-methylcitrate cycle
GO499_03975	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
GO499_03980	COG1012	belongs to the aldehyde dehydrogenase family
GO499_03985	COG1725	Transcriptional regulator
GO499_03990	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
GO499_03995	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
GO499_04000	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
GO499_04005	COG0589	response to stress
GO499_04010	COG3473	Maleate cis-trans isomerase
GO499_04015	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
GO499_04020	COG2423	ornithine cyclodeaminase activity
GO499_04025	COG0006	proline dipeptidase activity
GO499_04030	COG3608	succinylglutamate desuccinylase aspartoacylase
GO499_04070	COG2948	multi-organism process
GO499_04085	COG3846	protein secretion by the type IV secretion system
GO499_04095	COG3451	type IV secretory pathway VirB4
GO499_04110	COG4962	Type ii secretion system protein e
GO499_04150	COG0741	lytic transglycosylase activity
GO499_04185	COG3800	Transcriptional regulator
GO499_04185	COG1396	sequence-specific DNA binding
GO499_04210	COG5489	Protein of unknown function (DUF736)
GO499_04235	COG1475	DNA binding
GO499_04255	COG4974	Belongs to the 'phage' integrase family
GO499_04260	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GO499_04275	COG4235	cytochrome complex assembly
GO499_04280	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GO499_04295	COG0404	The glycine cleavage system catalyzes the degradation of glycine
GO499_04295	COG0446	pyridine nucleotide-disulphide oxidoreductase
GO499_04315	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GO499_04335	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
GO499_04360	COG1309	transcriptional regulator
GO499_04395	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
GO499_04400	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
GO499_04405	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
GO499_04425	COG1024	Enoyl-CoA hydratase
GO499_04450	COG3088	subunit of a heme lyase
GO499_04455	COG1138	Cytochrome C-type biogenesis protein
GO499_04465	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
GO499_04480	COG3739	integral membrane protein
GO499_04485	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
GO499_04490	COG0123	including yeast histone deacetylase and acetoin utilization protein
GO499_04500	COG2755	lipolytic protein G-D-S-L family
GO499_04500	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
GO499_04505	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
GO499_04510	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GO499_04515	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
GO499_04530	COG0482	sulfurtransferase activity
GO499_04540	COG0745	RESPONSE REGULATOR receiver
GO499_04550	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
GO499_04555	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
GO499_04570	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
GO499_04575	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GO499_04585	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
GO499_04590	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
GO499_04595	COG0629	single-stranded DNA binding
GO499_04600	COG0739	heme binding
GO499_04600	COG0741	lytic transglycosylase activity
GO499_04600	COG1196	nuclear chromosome segregation
GO499_04665	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
GO499_04670	COG1752	Esterase of the alpha-beta hydrolase superfamily
GO499_04700	COG0359	binds to the 23S rRNA
GO499_04705	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
GO499_04710	COG0360	Binds together with S18 to 16S ribosomal RNA
GO499_04715	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
GO499_04740	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GO499_04745	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
GO499_04760	COG4695	Portal protein
GO499_04845	COG1045	serine acetyltransferase
GO499_04860	COG0508	dehydrogenase complex catalyzes the overall conversion of
GO499_04865	COG0022	dehydrogenase e1 component
GO499_04865	COG0508	dehydrogenase complex catalyzes the overall conversion of
GO499_04870	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
GO499_04875	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
GO499_04885	COG1830	Aldolase
GO499_04890	COG0126	phosphoglycerate kinase activity
GO499_04900	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
GO499_04920	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
GO499_04930	COG0271	Belongs to the BolA IbaG family
GO499_04935	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GO499_04940	COG0583	DNA-binding transcription factor activity
GO499_04955	COG1272	protein, Hemolysin III
GO499_04960	COG0425	Belongs to the sulfur carrier protein TusA family
GO499_04960	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GO499_04965	COG0785	Cytochrome C biogenesis protein
GO499_05000	COG0114	fumarate hydratase activity
GO499_05015	COG0842	Transport permease protein
GO499_05020	COG1131	(ABC) transporter
GO499_05025	COG2089	acid synthase
GO499_05030	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
GO499_05035	COG1086	Polysaccharide biosynthesis protein
GO499_05040	COG1083	cytidylyl-transferase
GO499_05055	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GO499_05060	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GO499_05070	COG0649	NAD binding
GO499_05150	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
GO499_05165	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GO499_05210	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
GO499_05210	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
GO499_05215	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
GO499_05225	COG0513	Belongs to the DEAD box helicase family
GO499_05240	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
GO499_05255	COG1028	Short-chain dehydrogenase reductase Sdr
GO499_05270	COG3842	ATPase activity
GO499_05280	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GO499_05285	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GO499_05295	COG0805	protein transport
GO499_05310	COG1530	ribonuclease E activity
GO499_05320	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
GO499_05325	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
GO499_05340	COG0739	heme binding
GO499_05345	COG2833	Protein of unknown function (DUF455)
GO499_05350	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
GO499_05360	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
GO499_05375	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GO499_05390	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
GO499_05405	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
GO499_05410	COG2867	negative regulation of translational initiation
GO499_05415	COG2366	antibiotic biosynthetic process
GO499_05420	COG2084	Dehydrogenase
GO499_05430	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
GO499_05455	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
GO499_05470	COG0544	peptidyl-prolyl cis-trans isomerase activity
GO499_05495	COG0840	transmembrane signaling receptor activity
GO499_05500	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
GO499_05520	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
GO499_05525	COG0439	Biotin carboxylase
GO499_05540	COG0501	Belongs to the peptidase M48B family
GO499_05545	COG0436	Aminotransferase
GO499_05550	COG4942	peptidase
GO499_05555	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
GO499_05560	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
GO499_05585	COG1028	Short-chain dehydrogenase reductase Sdr
GO499_05590	COG4166	transmembrane transport
GO499_05605	COG2313	pseudouridylate synthase activity
GO499_05610	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GO499_05630	COG0052	Belongs to the universal ribosomal protein uS2 family
GO499_05635	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
GO499_05650	COG0233	cytoplasmic translational termination
GO499_05655	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
GO499_05665	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
GO499_05670	COG0750	zinc metalloprotease
GO499_05675	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GO499_05690	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GO499_05695	COG3494	Protein of unknown function (DUF1009)
GO499_05700	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GO499_05710	COG0372	Belongs to the citrate synthase family
GO499_05720	COG0658	competence protein
GO499_05720	COG2333	competence protein COMEC
GO499_05725	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
GO499_05735	COG0315	cyclic pyranopterin monophosphate synthase activity
GO499_05740	COG0134	indole-3-glycerol-phosphate synthase activity
GO499_05745	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
GO499_05760	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GO499_05770	COG0488	(ABC) transporter
GO499_05800	COG0667	Aldo Keto reductase
GO499_05830	COG0187	DNA topoisomerase II activity
GO499_05885	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
GO499_05890	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
GO499_05895	COG1862	Preprotein translocase
GO499_05900	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GO499_05905	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GO499_05915	COG3737	Protein of unknown function (DUF498/DUF598)
GO499_05940	COG5265	(ABC) transporter
GO499_05945	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GO499_05960	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GO499_05965	COG1160	GTP binding
GO499_05970	COG4172	Belongs to the ABC transporter superfamily
GO499_05980	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GO499_05985	COG0601	transmembrane transport
GO499_06005	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
GO499_06015	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
GO499_06035	COG1904	glucuronate isomerase
GO499_06040	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
GO499_06045	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
GO499_06065	COG1028	Short-chain dehydrogenase reductase Sdr
GO499_06070	COG0246	Mannitol dehydrogenase
GO499_06075	COG1312	Catalyzes the dehydration of D-mannonate
GO499_06090	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
GO499_06105	COG0569	domain protein
GO499_06110	COG2204	response regulator
GO499_06115	COG5000	phosphorelay sensor kinase activity
GO499_06120	COG2204	response regulator
GO499_06125	COG3852	Histidine kinase
GO499_06130	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GO499_06135	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
GO499_06135	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
GO499_06140	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
GO499_06145	COG1546	Belongs to the CinA family
GO499_06145	COG1058	Belongs to the CinA family
GO499_06150	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GO499_06170	COG0719	Fe-S assembly protein
GO499_06175	COG0396	ATPase activity
GO499_06190	COG0393	Putative heavy-metal-binding
GO499_06210	COG0719	Fe-S assembly protein
GO499_06215	COG1104	cysteine desulfurase activity
GO499_06225	COG2945	thiolester hydrolase activity
GO499_06235	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
GO499_06240	COG1127	ABC transporter
GO499_06255	COG1595	DNA-templated transcription, initiation
GO499_06300	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
GO499_06305	COG4221	oxidoreductase activity
GO499_06315	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
GO499_06330	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
GO499_06335	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GO499_06340	COG0047	phosphoribosylformylglycinamidine synthase activity
GO499_06350	COG2204	response regulator
GO499_06365	COG5012	cobalamin binding
GO499_06375	COG2166	iron-sulfur cluster assembly
GO499_06385	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
GO499_06390	COG0784	Response regulator, receiver
GO499_06390	COG4191	Histidine kinase
GO499_06395	COG4565	transcriptional regulatory protein
GO499_06405	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GO499_06425	COG1960	acyl-CoA dehydrogenase activity
GO499_06430	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO499_06435	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
GO499_06445	COG1024	Enoyl-CoA hydratase
GO499_06450	COG1612	heme a metabolic process
GO499_06455	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
GO499_06465	COG0538	isocitrate dehydrogenase activity
GO499_06480	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GO499_06585	COG1686	Belongs to the peptidase S11 family
GO499_06590	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
GO499_06595	COG0470	DNA polymerase III
GO499_06600	COG0084	hydrolase, TatD family'
GO499_06605	COG0321	lipoyl(octanoyl) transferase activity
GO499_06605	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
GO499_06620	COG0372	Belongs to the citrate synthase family
GO499_06630	COG0028	Belongs to the TPP enzyme family
GO499_06640	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GO499_06645	COG1116	anion transmembrane transporter activity
GO499_06655	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GO499_06660	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
GO499_06670	COG0640	Transcriptional regulator
GO499_06680	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
GO499_06685	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
GO499_06695	COG4948	Mandelate Racemase Muconate Lactonizing
GO499_06700	COG0105	UTP biosynthetic process
GO499_06705	COG0488	(ABC) transporter
GO499_06710	COG2095	MarC family integral membrane protein
GO499_06725	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
GO499_06745	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GO499_06750	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
GO499_06755	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
GO499_06765	COG2890	protein-(glutamine-N5) methyltransferase activity
GO499_06770	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
GO499_06785	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
GO499_06795	COG1846	Transcriptional regulator
GO499_06830	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
GO499_06850	COG0343	queuine tRNA-ribosyltransferase activity
GO499_06855	COG0189	ligase activity
GO499_06855	COG4067	protein conserved in archaea
GO499_06860	COG2151	metal-sulfur cluster biosynthetic enzyme
GO499_06870	COG0316	Belongs to the HesB IscA family
GO499_06875	COG0149	triose-phosphate isomerase activity
GO499_06915	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
GO499_06930	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
GO499_06935	COG0596	Alpha beta hydrolase
GO499_06940	COG2326	polyphosphate kinase activity
GO499_06950	COG1363	Peptidase, m42
GO499_06970	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
GO499_06980	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
GO499_06990	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
GO499_07005	COG0028	Belongs to the TPP enzyme family
GO499_07020	COG0440	acetolactate synthase activity
GO499_07030	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GO499_07045	COG2017	converts alpha-aldose to the beta-anomer
GO499_07050	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
GO499_07065	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GO499_07075	COG1278	Cold shock
GO499_07080	COG0259	pyridoxamine-phosphate oxidase activity
GO499_07085	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
GO499_07090	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
GO499_07100	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
GO499_07105	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
GO499_07115	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
GO499_07120	COG2204	response regulator
GO499_07120	COG2204	response regulator
GO499_07145	COG2124	cytochrome p450
GO499_07150	COG1473	amidohydrolase
GO499_07155	COG3956	TIGRFAM MazG family protein
GO499_07160	COG0148	phosphopyruvate hydratase activity
GO499_07170	COG1331	Highly conserved protein containing a thioredoxin domain
GO499_07180	COG1570	exodeoxyribonuclease VII activity
GO499_07185	COG0151	Belongs to the GarS family
GO499_07200	COG0587	DNA-directed DNA polymerase activity
GO499_07210	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GO499_07220	COG0330	HflC and HflK could
GO499_07225	COG0330	HflC and HflK could
GO499_07235	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
GO499_07240	COG1760	l-serine dehydratase
GO499_07255	COG3045	CreA protein
GO499_07265	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
GO499_07270	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GO499_07285	COG0436	Aminotransferase
GO499_07290	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
GO499_07295	COG0248	Ppx GppA phosphatase
GO499_07310	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
GO499_07320	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GO499_07350	COG2146	nitrite reductase [NAD(P)H] activity
GO499_07365	COG2116	formate transmembrane transporter activity
GO499_07380	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
GO499_07390	COG3871	stress protein (general stress protein 26)
GO499_07395	COG3237	CsbD-like
GO499_07405	COG0628	permease
GO499_07415	COG5510	response to toxic substance
GO499_07435	COG0784	Response regulator, receiver
GO499_07440	COG0783	Belongs to the Dps family
GO499_07480	COG0517	IMP dehydrogenase activity
GO499_07480	COG0516	GMP reductase activity
GO499_07495	COG1477	protein flavinylation
GO499_07505	COG1805	sodium ion transport
GO499_07535	COG0321	lipoyl(octanoyl) transferase activity
GO499_07570	COG0505	Belongs to the CarA family
GO499_07600	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GO499_07605	COG1522	sequence-specific DNA binding
GO499_07610	COG1522	sequence-specific DNA binding
GO499_07625	COG2814	Major facilitator Superfamily
GO499_07635	COG0504	CTP synthase activity
GO499_07645	COG1858	cytochrome C peroxidase
GO499_07655	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
GO499_07660	COG0010	Belongs to the arginase family
GO499_07665	COG0824	Thioesterase
GO499_07665	COG1250	3-hydroxyacyl-CoA dehydrogenase
GO499_07670	COG3246	L-lysine catabolic process to acetate
GO499_07695	COG2321	neutral zinc metallopeptidase
GO499_07705	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
GO499_07710	COG0840	transmembrane signaling receptor activity
GO499_07720	COG0400	carboxylic ester hydrolase activity
GO499_07730	COG2814	Major facilitator Superfamily
GO499_07750	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GO499_07755	COG0215	cysteine-tRNA ligase activity
GO499_07795	COG1028	Short-chain dehydrogenase reductase Sdr
GO499_07810	COG1028	Short-chain dehydrogenase reductase Sdr
GO499_07815	COG4573	that is required for full activity and stability of the Y subunit. Could have a chaperone-like function for the proper and stable folding of
GO499_07820	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GO499_07825	COG1082	Xylose isomerase domain protein TIM barrel
GO499_07830	COG2390	Transcriptional regulator
GO499_07840	COG1175	transmembrane transport
GO499_07855	COG1063	alcohol dehydrogenase
GO499_07860	COG3842	ATPase activity
GO499_07865	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GO499_07870	COG1028	Short-chain dehydrogenase reductase Sdr
GO499_07875	COG1070	Carbohydrate kinase
GO499_07895	COG1802	Transcriptional regulator
GO499_07900	COG2721	sulfolactate sulfo-lyase activity
GO499_07910	COG1172	Belongs to the binding-protein-dependent transport system permease family
GO499_07925	COG4774	siderophore transport
GO499_07930	COG3708	Transcriptional regulator
GO499_07930	COG2207	Transcriptional regulator
GO499_07965	COG4774	siderophore transport
GO499_07970	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
GO499_07975	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GO499_07980	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GO499_07985	COG1120	ATPase activity
GO499_08000	COG1629	transport
GO499_08010	COG0811	peptide transport
GO499_08030	COG4604	ABC transporter, ATP-binding protein
GO499_08035	COG4605	iron ion homeostasis
GO499_08040	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GO499_08045	COG4607	ABC-type enterochelin transport system periplasmic component
GO499_08050	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
GO499_08055	COG3842	ATPase activity
GO499_08065	COG1177	transmembrane transport
GO499_08080	COG1796	DNA polymerase
GO499_08080	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
GO499_08090	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GO499_08115	COG2267	carboxylic ester hydrolase activity
GO499_08135	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GO499_08135	COG3153	acetyltransferase
GO499_08140	COG1309	transcriptional regulator
GO499_08150	COG2267	carboxylic ester hydrolase activity
GO499_08175	COG0179	Fumarylacetoacetate (FAA) hydrolase
GO499_08180	COG1529	Aldehyde oxidase and xanthine dehydrogenase
GO499_08195	COG1181	Belongs to the D-alanine--D-alanine ligase family
GO499_08205	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GO499_08225	COG1917	Cupin 2, conserved barrel domain protein
GO499_08225	COG1396	sequence-specific DNA binding
GO499_08250	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
GO499_08255	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
GO499_08265	COG4974	Belongs to the 'phage' integrase family
GO499_08275	COG0640	Transcriptional regulator
GO499_08295	COG4536	flavin adenine dinucleotide binding
GO499_08300	COG0433	COG0433 Predicted ATPase
GO499_08325	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GO499_08335	COG3108	Peptidase M15
GO499_08340	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
GO499_08345	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
GO499_08350	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
GO499_08360	COG0211	Belongs to the bacterial ribosomal protein bL27 family
GO499_08365	COG3743	rRNA binding
GO499_08365	COG0261	This protein binds to 23S rRNA in the presence of protein L20
GO499_08435	COG0582	viral genome integration into host DNA
GO499_08450	COG1002	Type II restriction enzyme, methylase subunits
GO499_08460	COG1061	Type III restriction enzyme res subunit
GO499_08465	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
GO499_08505	COG3119	arylsulfatase activity
GO499_08525	COG4175	Glycine betaine
GO499_08550	COG0010	Belongs to the arginase family
GO499_08555	COG1116	anion transmembrane transporter activity
GO499_08575	COG1176	ABC-type spermidine putrescine transport system, permease component I
GO499_08660	COG4566	intracellular signal transduction
GO499_08665	COG0318	PFAM AMP-dependent synthetase and ligase
GO499_08690	COG0418	dihydroorotase activity
GO499_08700	COG0022	dehydrogenase e1 component
GO499_08705	COG3265	gluconokinase activity
GO499_08710	COG1028	Short-chain dehydrogenase reductase Sdr
GO499_08715	COG1063	alcohol dehydrogenase
GO499_08725	COG1132	(ABC) transporter
GO499_08740	COG0437	4 iron, 4 sulfur cluster binding
GO499_08745	COG3383	formate dehydrogenase (NAD+) activity
GO499_08745	COG0243	molybdopterin cofactor binding
GO499_08820	COG1012	belongs to the aldehyde dehydrogenase family
GO499_08830	COG0174	glutamine synthetase
GO499_08835	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
GO499_08855	COG0546	phosphoglycolate phosphatase activity
GO499_08860	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
GO499_08890	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GO499_08895	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
GO499_08905	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GO499_08915	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GO499_08920	COG2917	probably involved in intracellular septation
GO499_08945	COG0552	protein localization to endoplasmic reticulum
GO499_08950	COG0352	thiamine-phosphate diphosphorylase activity
GO499_08995	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
GO499_09000	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
GO499_09005	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
GO499_09025	COG0194	GDP metabolic process
GO499_09030	COG1561	YicC-like family, N-terminal region
GO499_09040	COG0560	Phosphoserine phosphatase
GO499_09045	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
GO499_09075	COG2133	pyrroloquinoline quinone binding
GO499_09080	COG1178	ABC-type Fe3 transport system permease component
GO499_09085	COG1840	ABC-type Fe3 transport system, periplasmic component
GO499_09100	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
GO499_09120	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
GO499_09125	COG1530	ribonuclease E activity
GO499_09130	COG0424	maF-like protein
GO499_09135	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
GO499_09145	COG5328	Belongs to the UPF0262 family
GO499_09150	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
GO499_09175	COG1132	(ABC) transporter
GO499_09185	COG0735	belongs to the Fur family
GO499_09190	COG1121	(ABC) transporter
GO499_09195	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GO499_09215	COG2304	oxidoreductase activity
GO499_09230	COG0714	Associated with various cellular activities
GO499_09240	COG2197	response regulator
GO499_09245	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
GO499_09250	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
GO499_09255	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
GO499_09260	COG1802	Transcriptional regulator
GO499_09265	COG3718	enzyme involved in inositol metabolism
GO499_09270	COG1082	Xylose isomerase domain protein TIM barrel
GO499_09275	COG3962	Belongs to the TPP enzyme family
GO499_09280	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GO499_09290	COG1172	Belongs to the binding-protein-dependent transport system permease family
GO499_09310	COG0673	inositol 2-dehydrogenase activity
GO499_09335	COG1172	Belongs to the binding-protein-dependent transport system permease family
GO499_09350	COG1012	belongs to the aldehyde dehydrogenase family
GO499_09365	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GO499_09385	COG0753	catalase activity
GO499_09395	COG1216	Glycosyl transferase, family 2
GO499_09410	COG2388	GCN5-related N-acetyl-transferase
GO499_09415	COG1741	Belongs to the pirin family
GO499_09425	COG1280	lysine exporter protein (LysE YggA)
GO499_09480	COG1028	Short-chain dehydrogenase reductase Sdr
GO499_09500	COG1653	transport
GO499_09505	COG0395	ABC-type sugar transport system, permease component
GO499_09510	COG4209	transmembrane transport
GO499_09515	COG3842	ATPase activity
GO499_09520	COG1802	Transcriptional regulator
GO499_09530	COG4948	Mandelate Racemase Muconate Lactonizing
GO499_09535	COG0673	inositol 2-dehydrogenase activity
GO499_09545	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GO499_09550	COG0583	DNA-binding transcription factor activity
GO499_09580	COG2358	TRAP transporter, solute receptor (TAXI family
GO499_09600	COG0626	cystathionine gamma-synthase activity
GO499_09605	COG1802	Transcriptional regulator
GO499_09615	COG0251	oxidation-reduction process
GO499_09665	COG1475	DNA binding
GO499_09720	COG0640	Transcriptional regulator
GO499_09730	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
GO499_09730	COG3264	Mechanosensitive ion channel
GO499_09740	COG0494	nUDIX hydrolase
GO499_09750	COG0300	oxidoreductase activity
GO499_09760	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
GO499_09775	COG0415	Belongs to the DNA photolyase family
GO499_09780	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GO499_09785	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GO499_09790	COG0604	alcohol dehydrogenase
GO499_09815	COG0556	nucleotide-excision repair
GO499_09850	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
GO499_09870	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
GO499_09880	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
GO499_09885	COG2205	protein histidine kinase activity
GO499_09890	COG0488	(ABC) transporter
GO499_09895	COG0501	Belongs to the peptidase M48B family
GO499_09900	COG1278	Cold shock
GO499_09905	COG1278	Cold shock
GO499_09920	COG0450	alkyl hydroperoxide reductase
GO499_09930	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GO499_09940	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GO499_09960	COG3046	protein related to deoxyribodipyrimidine photolyase
GO499_09985	COG0456	acetyltransferase
GO499_10010	COG0768	penicillin binding
GO499_10015	COG0772	Belongs to the SEDS family
GO499_10020	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GO499_10030	COG1573	uracil-dna glycosylase
GO499_10050	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
GO499_10070	COG2081	HI0933 family
GO499_10090	COG0010	Belongs to the arginase family
GO499_10110	COG2308	Evidence 4 Homologs of previously reported genes of
GO499_10110	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
GO499_10145	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
GO499_10160	COG2124	cytochrome p450
GO499_10185	COG0318	PFAM AMP-dependent synthetase and ligase
GO499_10200	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
GO499_10205	COG0179	Fumarylacetoacetate (FAA) hydrolase
GO499_10210	COG1028	Short-chain dehydrogenase reductase Sdr
GO499_10230	COG2084	Dehydrogenase
GO499_10240	COG1028	Short-chain dehydrogenase reductase Sdr
GO499_10245	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
GO499_10250	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GO499_10290	COG2239	Acts as a magnesium transporter
GO499_10295	COG0402	S-adenosylhomocysteine deaminase activity
GO499_10305	COG0534	Mate efflux family protein
GO499_10320	COG0789	Transcriptional regulator
GO499_10325	COG1960	acyl-CoA dehydrogenase activity
GO499_10355	COG0183	Belongs to the thiolase family
GO499_10375	COG1250	3-hydroxyacyl-CoA dehydrogenase
GO499_10375	COG1024	Enoyl-CoA hydratase
GO499_10390	COG0318	PFAM AMP-dependent synthetase and ligase
GO499_10400	COG1136	(ABC) transporter
GO499_10415	COG0442	prolyl-tRNA aminoacylation
GO499_10420	COG0248	Ppx GppA phosphatase
GO499_10425	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
GO499_10435	COG0628	permease
GO499_10445	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GO499_10470	COG1028	Short-chain dehydrogenase reductase Sdr
GO499_10480	COG4993	Dehydrogenase
GO499_10490	COG2080	2 iron, 2 sulfur cluster binding
GO499_10495	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
GO499_10500	COG1529	Aldehyde oxidase and xanthine dehydrogenase
GO499_10505	COG1329	Transcriptional regulator
GO499_10510	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
GO499_10515	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
GO499_10540	COG0483	inositol monophosphate 1-phosphatase activity
GO499_10545	COG1396	sequence-specific DNA binding
GO499_10550	COG1217	gtp-binding protein TYPA
GO499_10560	COG0604	alcohol dehydrogenase
GO499_10560	COG1028	Short-chain dehydrogenase reductase Sdr
GO499_10560	COG3321	synthase
GO499_10565	COG0583	DNA-binding transcription factor activity
GO499_10580	COG4181	ATPase activity
GO499_10585	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
GO499_10590	COG0670	Belongs to the BI1 family
GO499_10595	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
GO499_10600	COG0217	transcriptional regulatory protein
GO499_10605	COG0471	metal ion transport
GO499_10605	COG3273	potassium ion transport
GO499_10610	COG1692	metallophosphoesterase
GO499_10615	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
GO499_10645	COG0404	The glycine cleavage system catalyzes the degradation of glycine
GO499_10645	COG0446	pyridine nucleotide-disulphide oxidoreductase
GO499_10655	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GO499_10665	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
GO499_10670	COG0737	Belongs to the 5'-nucleotidase family
GO499_10680	COG0483	inositol monophosphate 1-phosphatase activity
GO499_10685	COG0354	folic acid binding
GO499_10695	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
GO499_10700	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GO499_10705	COG0525	valine-tRNA ligase activity
GO499_10715	COG3179	chitinase
GO499_10730	COG2076	Multidrug Resistance protein
GO499_10755	COG2010	Cytochrome c
GO499_10780	COG0436	Aminotransferase
GO499_10805	COG1494	fructose-1,6-bisphosphatase
GO499_10830	COG1940	carbohydrate kinase activity
GO499_10835	COG4213	ABC transporter substrate-binding protein
GO499_10840	COG4214	carbohydrate transport
GO499_10855	COG0745	RESPONSE REGULATOR receiver
GO499_10865	COG1522	sequence-specific DNA binding
GO499_10870	COG0404	The glycine cleavage system catalyzes the degradation of glycine
GO499_10880	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GO499_10890	COG0745	RESPONSE REGULATOR receiver
GO499_10900	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GO499_10905	COG0581	inorganic phosphate transmembrane transporter activity
GO499_10910	COG0573	inorganic phosphate transmembrane transporter activity
GO499_10920	COG5002	protein histidine kinase activity
GO499_10955	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
GO499_10980	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GO499_10985	COG0612	Peptidase, M16
GO499_11015	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
GO499_11035	COG0312	modulator of DNA gyrase
GO499_11040	COG3454	Phosphonate metabolism
GO499_11050	COG4778	phosphonate C-P lyase system protein PhnL
GO499_11055	COG4107	phosphonate C-P lyase system protein PhnK
GO499_11065	COG3627	carbon phosphorus lyase activity
GO499_11070	COG3626	phosphonate metabolism
GO499_11075	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
GO499_11080	COG3624	Phosphonate C-P lyase system protein PhnG
GO499_11090	COG3454	Phosphonate metabolism
GO499_11095	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
GO499_11100	COG3639	organic phosphonate transmembrane transporter activity
GO499_11105	COG3639	organic phosphonate transmembrane transporter activity
GO499_11110	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
GO499_11115	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
GO499_11120	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GO499_11125	COG0569	domain protein
GO499_11130	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GO499_11145	COG0702	epimerase
GO499_11150	COG1733	regulation of RNA biosynthetic process
GO499_11160	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
GO499_11165	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
GO499_11220	COG2080	2 iron, 2 sulfur cluster binding
GO499_11225	COG1529	Aldehyde oxidase and xanthine dehydrogenase
GO499_11235	COG1129	ABC transporter
GO499_11240	COG4603	Belongs to the binding-protein-dependent transport system permease family
GO499_11245	COG1079	Belongs to the binding-protein-dependent transport system permease family
GO499_11265	COG0667	Aldo Keto reductase
GO499_11270	COG1492	cobalamin metabolic process
GO499_11275	COG1408	metallophosphoesterase
GO499_11420	COG1960	acyl-CoA dehydrogenase activity
GO499_11430	COG1054	Belongs to the UPF0176 family
GO499_11435	COG1309	transcriptional regulator
GO499_11445	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
GO499_11480	COG0228	four-way junction DNA binding
GO499_11485	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
GO499_11490	COG0336	Belongs to the RNA methyltransferase TrmD family
GO499_11495	COG0335	large ribosomal subunit rRNA binding
GO499_11505	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
GO499_11510	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
GO499_11515	COG0085	RNA polymerase activity
GO499_11520	COG0222	ribosome binding
GO499_11525	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
GO499_11530	COG0081	regulation of translation
GO499_11535	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
GO499_11540	COG0250	Participates in transcription elongation, termination and antitermination
GO499_11545	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GO499_11550	COG1414	Transcriptional regulator
GO499_11555	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
GO499_11565	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
GO499_11570	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
GO499_11575	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
GO499_11590	COG3022	response to hydroperoxide
GO499_11600	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
GO499_11605	COG2897	thiosulfate sulfurtransferase activity
GO499_11620	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GO499_11645	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
GO499_11650	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GO499_11665	COG0577	efflux transmembrane transporter activity
GO499_11715	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
GO499_11725	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
GO499_11725	COG2010	Cytochrome c
GO499_11730	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
GO499_11760	COG2032	superoxide dismutase activity
GO499_11815	COG2814	Major facilitator Superfamily
GO499_11840	COG1733	regulation of RNA biosynthetic process
GO499_11855	COG5002	protein histidine kinase activity
GO499_11855	COG3850	Histidine kinase
GO499_11870	COG0230	Belongs to the bacterial ribosomal protein bL34 family
GO499_11875	COG0594	ribonuclease P activity
GO499_11880	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
GO499_11905	COG0037	tRNA processing
GO499_11915	COG0706	membrane insertase activity
GO499_11925	COG0218	Necessary for normal cell division and for the maintenance of normal septation
GO499_11935	COG5507	3-demethylubiquinone-9 3-methyltransferase
GO499_11980	COG4770	biotin carboxylase activity
GO499_11990	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GO499_11995	COG1960	acyl-CoA dehydrogenase activity
GO499_12005	COG0131	Imidazoleglycerol-phosphate dehydratase
GO499_12010	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
GO499_12030	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
GO499_12040	COG0107	imidazoleglycerol-phosphate synthase activity
GO499_12045	COG0140	phosphoribosyl-ATP diphosphatase activity
GO499_12070	COG2358	TRAP transporter, solute receptor (TAXI family
GO499_12090	COG0395	ABC-type sugar transport system, permease component
GO499_12095	COG1175	transmembrane transport
GO499_12100	COG3842	ATPase activity
GO499_12105	COG3842	ATPase activity
GO499_12115	COG0758	DNA mediated transformation
GO499_12125	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GO499_12125	COG1754	DNA topoisomerase type I activity
GO499_12145	COG0557	exoribonuclease II activity
GO499_12155	COG1733	regulation of RNA biosynthetic process
GO499_12160	COG0604	alcohol dehydrogenase
GO499_12165	COG2951	lytic endotransglycosylase activity
GO499_12170	COG2863	cytochrome
GO499_12185	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
GO499_12200	COG2249	NAD(P)H dehydrogenase (quinone) activity
GO499_12255	COG0459	protein refolding
GO499_12260	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
GO499_12280	COG2030	dehydratase
GO499_12285	COG0196	riboflavin kinase activity
GO499_12315	COG4952	isomerase
GO499_12320	COG1028	Short-chain dehydrogenase reductase Sdr
GO499_12320	COG3347	Dehydrogenase
GO499_12335	COG1129	ABC transporter
GO499_12340	COG1172	Belongs to the binding-protein-dependent transport system permease family
GO499_12345	COG1172	Belongs to the binding-protein-dependent transport system permease family
GO499_12350	COG3254	rhamnose metabolic process
GO499_12390	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
GO499_12405	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
GO499_12425	COG1115	amino acid carrier protein
GO499_12435	COG0606	chelatase, subunit chli
GO499_12450	COG0792	nuclease activity
GO499_12455	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
GO499_12465	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
GO499_12480	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
GO499_12485	COG0072	phenylalanine-tRNA ligase activity
GO499_12485	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GO499_12495	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
GO499_12510	COG1385	rRNA (uridine-N3-)-methyltransferase activity
GO499_12515	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
GO499_12530	COG0314	molybdopterin synthase activity
GO499_12540	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
GO499_12545	COG0322	excinuclease ABC activity
GO499_12560	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
GO499_12560	COG0616	signal peptide processing
GO499_12575	COG1741	Belongs to the pirin family
GO499_12580	COG1819	glycosyl
GO499_12610	COG0612	Peptidase, M16
GO499_12615	COG0612	Peptidase, M16
GO499_12625	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
GO499_12645	COG1162	GTPase activity
GO499_12660	COG0501	Belongs to the peptidase M48B family
GO499_12665	COG5508	conserved small protein
GO499_12700	COG0356	it plays a direct role in the translocation of protons across the membrane
GO499_12705	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GO499_12710	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
GO499_12715	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
GO499_12735	COG2814	Major facilitator Superfamily
GO499_12760	COG0251	oxidation-reduction process
GO499_12770	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
GO499_12790	COG1028	Short-chain dehydrogenase reductase Sdr
GO499_12795	COG1999	signal sequence binding
GO499_12810	COG3178	'Phosphotransferase
GO499_12815	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
GO499_12840	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
GO499_12845	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
GO499_12855	COG0596	Alpha beta hydrolase
GO499_12865	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
GO499_12870	COG0456	acetyltransferase
GO499_12870	COG1214	PFAM Peptidase M22, glycoprotease
GO499_12885	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
GO499_12905	COG2171	N-acyltransferase activity
GO499_12925	COG1335	isochorismatase
GO499_12940	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
GO499_12945	COG2951	lytic endotransglycosylase activity
GO499_12955	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GO499_12960	COG2814	Major facilitator Superfamily
GO499_12965	COG1846	Transcriptional regulator
GO499_12970	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
GO499_12995	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
GO499_13000	COG0351	phosphomethylpyrimidine kinase
GO499_13005	COG0673	inositol 2-dehydrogenase activity
GO499_13015	COG0673	inositol 2-dehydrogenase activity
GO499_13025	COG2115	Belongs to the xylose isomerase family
GO499_13030	COG1070	Carbohydrate kinase
GO499_13040	COG1609	Transcriptional regulator
GO499_13045	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
GO499_13055	COG1595	DNA-templated transcription, initiation
GO499_13065	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GO499_13070	COG0741	lytic transglycosylase activity
GO499_13075	COG0697	spore germination
GO499_13080	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
GO499_13080	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GO499_13085	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GO499_13085	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
GO499_13095	COG0431	NADPH-dependent FMN reductase
GO499_13130	COG0798	PFAM Bile acid sodium symporter
GO499_13135	COG1850	ribulose-bisphosphate carboxylase activity
GO499_13195	COG0318	PFAM AMP-dependent synthetase and ligase
GO499_13215	COG1177	transmembrane transport
GO499_13220	COG1176	ABC-type spermidine putrescine transport system, permease component I
GO499_13225	COG3842	ATPase activity
GO499_13240	COG0693	protein deglycase activity
GO499_13265	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GO499_13275	COG0745	RESPONSE REGULATOR receiver
GO499_13295	COG0346	lactoylglutathione lyase activity
GO499_13315	COG0778	Nitroreductase
GO499_13345	COG1309	transcriptional regulator
GO499_13350	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
GO499_13355	COG3768	UPF0283 membrane protein
GO499_13365	COG3106	COG3106 Predicted ATPase
GO499_13370	COG0101	tRNA pseudouridine synthase activity
GO499_13430	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
GO499_13435	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
GO499_13440	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
GO499_13450	COG0542	response to heat
GO499_13455	COG0823	Involved in the tonB-independent uptake of proteins
GO499_13465	COG0284	orotidine-5'-phosphate decarboxylase activity
GO499_13470	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GO499_13485	COG0257	Belongs to the bacterial ribosomal protein bL36 family
GO499_13520	COG0559	Belongs to the binding-protein-dependent transport system permease family
GO499_13560	COG1595	DNA-templated transcription, initiation
GO499_13565	COG2304	oxidoreductase activity
GO499_13570	COG0071	Belongs to the small heat shock protein (HSP20) family
GO499_13605	COG0404	The glycine cleavage system catalyzes the degradation of glycine
GO499_13610	COG0247	lactate metabolic process
GO499_13620	COG0277	FAD linked oxidase domain protein
GO499_13625	COG0277	FAD linked oxidase domain protein
GO499_13630	COG2814	Major facilitator Superfamily
GO499_13655	COG0714	Associated with various cellular activities
GO499_13675	COG1051	belongs to the nudix hydrolase family
GO499_13680	COG0793	Belongs to the peptidase S41A family
GO499_13690	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
GO499_13695	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
GO499_13700	COG0799	negative regulation of ribosome biogenesis
GO499_13755	COG0339	signal peptide processing
GO499_13760	COG4957	zinc ion binding
GO499_13765	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GO499_13770	COG1702	phosphate starvation-inducible protein PhoH
GO499_13785	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
GO499_13790	COG1253	flavin adenine dinucleotide binding
GO499_13795	COG0815	Transfers the fatty acyl group on membrane lipoproteins
GO499_13800	COG0220	tRNA (guanine-N7-)-methyltransferase activity
GO499_13805	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
GO499_13810	COG0539	negative regulation of cytoplasmic translation
GO499_13815	COG0616	signal peptide processing
GO499_13820	COG0776	regulation of translation
GO499_13830	COG0135	phosphoribosylanthranilate isomerase activity
GO499_13835	COG0133	tryptophan synthase activity
GO499_13850	COG0193	aminoacyl-tRNA hydrolase activity
GO499_13855	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
GO499_13870	COG0589	response to stress
GO499_13875	COG0659	secondary active sulfate transmembrane transporter activity
GO499_13895	COG0159	tryptophan synthase activity
GO499_13900	COG0012	GTP binding
GO499_13910	COG0745	RESPONSE REGULATOR receiver
GO499_13915	COG1846	Transcriptional regulator
GO499_13925	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GO499_13930	COG1072	(Pantothenic acid kinase))
GO499_13950	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GO499_13950	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GO499_13960	COG2186	Transcriptional regulator
GO499_13970	COG1129	ABC transporter
GO499_13975	COG1172	Belongs to the binding-protein-dependent transport system permease family
GO499_13980	COG1172	Belongs to the binding-protein-dependent transport system permease family
GO499_13985	COG0747	negative chemotaxis
GO499_13995	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GO499_14005	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
GO499_14015	COG0747	negative chemotaxis
GO499_14030	COG2983	Belongs to the UPF0260 family
GO499_14060	COG0355	proton-transporting ATP synthase activity, rotational mechanism
GO499_14065	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
GO499_14070	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
GO499_14085	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
GO499_14095	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GO499_14110	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
GO499_14115	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GO499_14120	COG0287	Prephenate dehydrogenase
GO499_14135	COG0697	spore germination
GO499_14150	COG1175	transmembrane transport
GO499_14155	COG0395	ABC-type sugar transport system, permease component
GO499_14170	COG3842	ATPase activity
GO499_14180	COG1744	ABC transporter substrate-binding protein PnrA-like
GO499_14185	COG3845	ABC transporter
GO499_14200	COG1280	lysine exporter protein (LysE YggA)
GO499_14205	COG1079	Belongs to the binding-protein-dependent transport system permease family
GO499_14210	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
GO499_14220	COG0730	response to heat
GO499_14235	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GO499_14235	COG1017	nitric oxide dioxygenase activity
GO499_14255	COG0656	L-ascorbic acid biosynthetic process
GO499_14270	COG2197	response regulator
GO499_14275	COG0604	alcohol dehydrogenase
GO499_14280	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
GO499_14280	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
GO499_14325	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
GO499_14335	COG2030	dehydratase
GO499_14365	COG0039	L-malate dehydrogenase activity
GO499_14380	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
GO499_14390	COG0567	Dehydrogenase, E1 component
GO499_14395	COG0508	dehydrogenase complex catalyzes the overall conversion of
GO499_14450	COG1461	Dihydroxyacetone kinase
GO499_14455	COG0287	Prephenate dehydrogenase
GO499_14475	COG1129	ABC transporter
GO499_14480	COG1172	Belongs to the binding-protein-dependent transport system permease family
GO499_14485	COG0667	Aldo Keto reductase
GO499_14505	COG1129	ABC transporter
GO499_14525	COG0235	Class ii aldolase
GO499_14530	COG3395	kinase activity
GO499_14550	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
GO499_14555	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
GO499_14560	COG0473	3-isopropylmalate dehydrogenase activity
GO499_14580	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
GO499_14595	COG3181	Tripartite tricarboxylate transporter family receptor
GO499_14605	COG1053	succinate dehydrogenase
GO499_14630	COG0348	domain, Protein
GO499_14635	COG2010	Cytochrome c
GO499_14660	COG3845	ABC transporter
GO499_14665	COG4603	Belongs to the binding-protein-dependent transport system permease family
GO499_14670	COG1079	Belongs to the binding-protein-dependent transport system permease family
GO499_14695	COG1115	amino acid carrier protein
GO499_14700	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GO499_14705	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
GO499_14720	COG0679	Auxin Efflux Carrier
GO499_14725	COG2095	MarC family integral membrane protein
GO499_14730	COG1672	PFAM Archaeal ATPase
GO499_14730	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
GO499_14745	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
GO499_14750	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GO499_14755	COG1959	2 iron, 2 sulfur cluster binding
GO499_14760	COG0471	metal ion transport
GO499_14760	COG3273	potassium ion transport
GO499_14770	COG2217	Heavy metal translocating P-type atpase
GO499_14780	COG3239	Fatty acid desaturase
GO499_14790	COG1671	Belongs to the UPF0178 family
GO499_14810	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
GO499_14825	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
GO499_14840	COG1706	bacterial-type flagellum-dependent cell motility
GO499_14875	COG0662	Cupin 2, conserved barrel domain protein
GO499_14890	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
GO499_14895	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GO499_14900	COG0747	negative chemotaxis
GO499_14910	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GO499_14920	COG1012	belongs to the aldehyde dehydrogenase family
GO499_14945	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
GO499_14950	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
GO499_14965	COG2835	tetraacyldisaccharide 4'-kinase activity
GO499_14975	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GO499_14980	COG0154	amidase activity
GO499_15025	COG1132	(ABC) transporter
GO499_15035	COG1522	sequence-specific DNA binding
GO499_15040	COG1648	precorrin-2 dehydrogenase activity
GO499_15040	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GO499_15050	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GO499_15055	COG0175	sulfate reduction
GO499_15145	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
GO499_15145	COG2755	lipolytic protein G-D-S-L family
GO499_15165	COG1215	transferase activity, transferring glycosyl groups
GO499_15170	COG1215	transferase activity, transferring glycosyl groups
GO499_15200	COG1595	DNA-templated transcription, initiation
GO499_15215	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
GO499_15220	COG0066	3-isopropylmalate dehydratase activity
GO499_15245	COG0473	3-isopropylmalate dehydrogenase activity
GO499_15250	COG0840	transmembrane signaling receptor activity
GO499_15260	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
GO499_15290	COG5443	negative regulation of bacterial-type flagellum assembly
GO499_15305	COG1815	bacterial-type flagellum-dependent cell motility
GO499_15310	COG1558	bacterial-type flagellum-dependent cell motility
GO499_15315	COG1677	Flagellar hook-basal body complex protein FliE
GO499_15320	COG1987	bacterial-type flagellum assembly
GO499_15325	COG4786	Flagellar basal body rod
GO499_15330	COG4786	Flagellar basal body rod
GO499_15340	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
GO499_15355	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
GO499_15365	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
GO499_15375	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
GO499_15385	COG1216	Glycosyl transferase, family 2
GO499_15395	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
GO499_15400	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
GO499_15405	COG0181	hydroxymethylbilane synthase activity
GO499_15410	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
GO499_15430	COG1956	GAF domain-containing protein
GO499_15435	COG0004	ammonium transporteR
GO499_15440	COG0347	Belongs to the P(II) protein family
GO499_15445	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
GO499_15465	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GO499_15485	COG2154	pterin-4-alpha-carbinolamine dehydratase
GO499_15490	COG0678	peroxiredoxin activity
GO499_15500	COG0742	ribosomal rna small subunit methyltransferase
GO499_15505	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
GO499_15520	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
GO499_15540	COG1131	(ABC) transporter
GO499_15545	COG1116	anion transmembrane transporter activity
GO499_15590	COG1733	regulation of RNA biosynthetic process
GO499_15595	COG1902	pentaerythritol trinitrate reductase activity
GO499_15600	COG0667	Aldo Keto reductase
GO499_15625	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
GO499_15630	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
GO499_15675	COG3791	Glutathione-dependent formaldehyde-activating
GO499_15715	COG0714	Associated with various cellular activities
GO499_15725	COG0028	Belongs to the TPP enzyme family
GO499_15740	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
GO499_15785	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GO499_15820	COG1968	undecaprenyl-diphosphatase activity
GO499_15840	COG2815	serine threonine protein kinase
GO499_15840	COG0515	serine threonine protein kinase
GO499_15950	COG2205	protein histidine kinase activity
GO499_15995	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
GO499_16005	COG0405	Gamma-glutamyltransferase
GO499_16010	COG3034	peptidoglycan biosynthetic process
GO499_16015	COG0156	8-amino-7-oxononanoate synthase activity
GO499_16025	COG0534	Mate efflux family protein
GO499_16030	COG2723	6-phospho-beta-galactosidase activity
GO499_16035	COG1609	Transcriptional regulator
GO499_16040	COG1653	transport
GO499_16045	COG1175	transmembrane transport
GO499_16050	COG0395	ABC-type sugar transport system, permease component
GO499_16055	COG0366	Alpha amylase catalytic
GO499_16060	COG3842	ATPase activity
GO499_16085	COG0564	pseudouridine synthase activity
GO499_16095	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
GO499_16105	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
GO499_16130	COG3030	protein affecting phage T7 exclusion by the F plasmid
GO499_16135	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
GO499_16145	COG0237	dephospho-CoA kinase activity
GO499_16150	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
GO499_16155	COG0424	maF-like protein
GO499_16160	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
GO499_16165	COG1981	membrane
GO499_16170	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
GO499_16175	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
GO499_16180	COG0445	tRNA wobble uridine modification
GO499_16185	COG0357	Ribosomal RNA small subunit methyltransferase G
GO499_16200	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GO499_16205	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
GO499_16210	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
GO499_16215	COG1420	regulation of RNA biosynthetic process
GO499_16220	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
GO499_16245	COG0495	leucyl-tRNA aminoacylation
GO499_16265	COG0529	Catalyzes the synthesis of activated sulfate
GO499_16265	COG2046	Belongs to the sulfate adenylyltransferase family
GO499_16270	COG0729	surface antigen
GO499_16290	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
GO499_16310	COG0463	Glycosyl transferase, family 2
GO499_16310	COG1216	Glycosyl transferase, family 2
GO499_16325	COG1216	Glycosyl transferase, family 2
GO499_16350	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
GO499_16355	COG0135	phosphoribosylanthranilate isomerase activity
GO499_16360	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
GO499_16365	COG2226	methyltransferase
GO499_16370	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
GO499_16380	COG0268	Binds directly to 16S ribosomal RNA
GO499_16400	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
GO499_16410	COG1280	lysine exporter protein (LysE YggA)
GO499_16420	COG2199	diguanylate cyclase activity
GO499_16425	COG0776	regulation of translation
GO499_16430	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
GO499_16435	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GO499_16460	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
GO499_16465	COG3257	ureidoglycine aminohydrolase activity
GO499_16475	COG2351	hydroxyisourate hydrolase activity
GO499_16485	COG1802	Transcriptional regulator
GO499_16505	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GO499_16510	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
GO499_16645	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
GO499_16665	COG0625	glutathione transferase activity
GO499_16675	COG2808	Putative FMN-binding domain
GO499_16685	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GO499_16710	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
GO499_16715	COG3264	Mechanosensitive ion channel
GO499_16715	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
GO499_16720	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
GO499_16730	COG0367	asparagine synthase
GO499_16750	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
GO499_16755	COG1522	sequence-specific DNA binding
GO499_16760	COG0514	ATP-dependent DNA helicase (RecQ)
GO499_16765	COG3300	MHYT domain
GO499_16765	COG5001	Diguanylate cyclase
GO499_16770	COG2897	thiosulfate sulfurtransferase activity
GO499_16785	COG2423	ornithine cyclodeaminase activity
GO499_16790	COG0529	Catalyzes the synthesis of activated sulfate
GO499_16790	COG2046	Belongs to the sulfate adenylyltransferase family
GO499_16795	COG0529	Catalyzes the synthesis of activated sulfate
GO499_16795	COG2046	Belongs to the sulfate adenylyltransferase family
GO499_16805	COG0288	reversible hydration of carbon dioxide
GO499_16815	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
GO499_16820	COG0791	NLP P60 protein
GO499_16835	COG1028	Short-chain dehydrogenase reductase Sdr
GO499_16840	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
GO499_16845	COG1185	polyribonucleotide nucleotidyltransferase activity
GO499_16850	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GO499_16855	COG1940	carbohydrate kinase activity
GO499_16865	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
GO499_16880	COG0779	Required for maturation of 30S ribosomal subunits
GO499_16885	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
GO499_16890	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
GO499_16910	COG0366	Alpha amylase catalytic
GO499_16920	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
GO499_16930	COG3008	intermembrane lipid transfer
GO499_16930	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
GO499_16935	COG2995	paraquat-inducible protein a
GO499_16965	COG0443	Heat shock 70 kDa protein
GO499_16995	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GO499_17000	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
GO499_17010	COG0305	Participates in initiation and elongation during chromosome replication
GO499_17025	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
GO499_17030	COG0129	dihydroxy-acid dehydratase activity
GO499_17040	COG0800	Aldolase
GO499_17045	COG0166	Belongs to the GPI family
GO499_17060	COG1194	a g-specific adenine glycosylase
GO499_17070	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GO499_17075	COG1663	tetraacyldisaccharide 4'-kinase activity
GO499_17080	COG1519	Transferase
GO499_17095	COG0312	modulator of DNA gyrase
GO499_17110	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
GO499_17115	COG4149	molybdate abc transporter
GO499_17120	COG0725	ABC transporter, periplasmic molybdate-binding protein
GO499_17130	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GO499_17135	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GO499_17135	COG1321	iron dependent repressor
GO499_17140	COG1121	(ABC) transporter
GO499_17145	COG0803	Belongs to the bacterial solute-binding protein 9 family
GO499_17170	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
GO499_17175	COG5000	phosphorelay sensor kinase activity
GO499_17175	COG5002	protein histidine kinase activity
GO499_17185	COG0745	RESPONSE REGULATOR receiver
GO499_17215	COG0410	ABC transporter
GO499_17220	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GO499_17240	COG0587	DNA-directed DNA polymerase activity
GO499_17260	COG1338	Plays a role in the flagellum-specific transport system
GO499_17265	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GO499_17275	COG1766	The M ring may be actively involved in energy transduction
GO499_17305	COG2308	Evidence 4 Homologs of previously reported genes of
GO499_17350	COG0829	nickel cation binding
GO499_17355	COG0831	urea catabolic process
GO499_17360	COG0832	Belongs to the urease beta subunit family
GO499_17385	COG0804	urea catabolic process
GO499_17415	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
GO499_17445	COG1218	3'(2'),5'-bisphosphate nucleotidase
GO499_17450	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
GO499_17455	COG0463	Glycosyl transferase, family 2
GO499_17465	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GO499_17485	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GO499_17490	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
GO499_17495	COG1137	ATPase activity
GO499_17510	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
GO499_17510	COG0517	IMP dehydrogenase activity
GO499_17515	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GO499_17530	COG0745	RESPONSE REGULATOR receiver
GO499_17540	COG1116	anion transmembrane transporter activity
GO499_17540	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
GO499_17545	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GO499_17550	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
GO499_17550	COG1116	anion transmembrane transporter activity
GO499_17565	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GO499_17570	COG2146	nitrite reductase [NAD(P)H] activity
GO499_17575	COG0243	molybdopterin cofactor binding
GO499_17580	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GO499_17580	COG1648	precorrin-2 dehydrogenase activity
GO499_17590	COG1902	pentaerythritol trinitrate reductase activity
GO499_17590	COG0446	pyridine nucleotide-disulphide oxidoreductase
GO499_17600	COG0129	dihydroxy-acid dehydratase activity
GO499_17605	COG2197	response regulator
GO499_17610	COG1266	CAAX protease self-immunity
GO499_17615	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
GO499_17620	COG0285	dihydrofolate synthase activity
GO499_17625	COG1280	lysine exporter protein (LysE YggA)
GO499_17635	COG0679	Auxin Efflux Carrier
GO499_17645	COG0583	DNA-binding transcription factor activity
GO499_17650	COG0583	DNA-binding transcription factor activity
GO499_17675	COG0024	Methionine aminopeptidase
GO499_17690	COG2198	Histidine kinase
GO499_17690	COG0643	Histidine kinase
GO499_17695	COG0835	chemotaxis
GO499_17700	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
GO499_17705	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
GO499_17710	COG2201	protein-glutamate methylesterase activity
GO499_17725	COG2943	transferase activity, transferring hexosyl groups
GO499_17730	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
GO499_17750	COG0028	Belongs to the TPP enzyme family
GO499_17760	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
GO499_17765	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
GO499_17790	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GO499_17795	COG2358	TRAP transporter, solute receptor (TAXI family
GO499_17800	COG4608	Belongs to the ABC transporter superfamily
GO499_17805	COG0444	Belongs to the ABC transporter superfamily
GO499_17810	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GO499_17815	COG0601	transmembrane transport
GO499_17825	COG0747	negative chemotaxis
GO499_17835	COG0446	pyridine nucleotide-disulphide oxidoreductase
GO499_17840	COG2863	cytochrome
GO499_17855	COG0596	Alpha beta hydrolase
GO499_17860	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GO499_17890	COG0494	nUDIX hydrolase
GO499_17895	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
GO499_17900	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GO499_17905	COG0653	protein targeting
GO499_17925	COG2003	Belongs to the UPF0758 family
GO499_17935	COG0024	Methionine aminopeptidase
GO499_17940	COG1489	DNA binding
GO499_17945	COG1058	Belongs to the CinA family
GO499_17945	COG1546	Belongs to the CinA family
GO499_17950	COG1414	Transcriptional regulator
GO499_17955	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
GO499_17960	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
GO499_17965	COG3616	Alanine racemase, N-terminal domain
GO499_17970	COG2423	ornithine cyclodeaminase activity
GO499_17995	COG1335	isochorismatase
GO499_18010	COG3842	ATPase activity
GO499_18040	COG1609	Transcriptional regulator
GO499_18050	COG1175	transmembrane transport
GO499_18055	COG0395	ABC-type sugar transport system, permease component
GO499_18075	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GO499_18080	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
GO499_18090	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
GO499_18095	COG2885	chlorophyll binding
GO499_18100	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
GO499_18105	COG0142	geranyltranstransferase activity
GO499_18110	COG1722	exodeoxyribonuclease VII activity
GO499_18115	COG0123	including yeast histone deacetylase and acetoin utilization protein
GO499_18125	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GO499_18135	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
GO499_18140	COG1994	Peptidase M50
GO499_18150	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
GO499_18180	COG0408	coproporphyrinogen oxidase activity
GO499_18190	COG1132	(ABC) transporter
GO499_18195	COG1132	(ABC) transporter
GO499_18200	COG1132	(ABC) transporter
GO499_18205	COG1132	(ABC) transporter
GO499_18225	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
GO499_18230	COG2514	catechol 2,3-dioxygenase activity
GO499_18235	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GO499_18250	COG0180	Tryptophanyl-tRNA synthetase
GO499_18255	COG0456	acetyltransferase
GO499_18265	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
GO499_18275	COG4143	(ABC) transporter
GO499_18285	COG5425	PFAM Usg family protein
GO499_18290	COG0625	glutathione transferase activity
GO499_18295	COG1970	mechanosensitive ion channel activity
GO499_18300	COG0686	Belongs to the AlaDH PNT family
GO499_18320	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
GO499_18330	COG0746	molybdenum cofactor guanylyltransferase activity
GO499_18345	COG0405	Gamma-glutamyltransferase
GO499_18385	COG1763	Mo-molybdopterin cofactor biosynthetic process
GO499_18390	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GO499_18400	COG0303	'Molybdopterin
GO499_18415	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GO499_18455	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
GO499_18460	COG0142	geranyltranstransferase activity
GO499_18470	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GO499_18480	COG0518	GMP synthase (glutamine-hydrolyzing) activity
GO499_18480	COG0519	Catalyzes the synthesis of GMP from XMP
GO499_18485	COG0583	DNA-binding transcription factor activity
GO499_18515	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
GO499_18525	COG3720	iron ion transport
GO499_18530	COG4558	Periplasmic binding protein
GO499_18535	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GO499_18540	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
GO499_18550	COG0811	peptide transport
GO499_18580	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GO499_18585	COG0165	Argininosuccinate lyase
GO499_18610	COG3264	Mechanosensitive ion channel
GO499_18610	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
GO499_18620	COG1280	lysine exporter protein (LysE YggA)
GO499_18625	COG0477	Major facilitator Superfamily
GO499_18665	COG2884	Cell division ATP-binding protein ftsE
GO499_18680	COG0825	malonyl-CoA metabolic process
GO499_18685	COG2301	Belongs to the HpcH HpaI aldolase family
GO499_18690	COG2814	Major facilitator Superfamily
GO499_18695	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
GO499_18700	COG0242	peptide deformylase activity
GO499_18705	COG0242	peptide deformylase activity
GO499_18710	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
GO499_18720	COG0328	RNA-DNA hybrid ribonuclease activity
GO499_18735	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
GO499_18740	COG1573	uracil-dna glycosylase
GO499_18750	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
GO499_18770	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
GO499_18780	COG0736	holo-[acyl-carrier-protein] synthase activity
GO499_18785	COG0681	Belongs to the peptidase S26 family
GO499_18790	COG0571	ribonuclease III activity
GO499_18795	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
GO499_18820	COG1529	Aldehyde oxidase and xanthine dehydrogenase
GO499_18885	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
GO499_18890	COG0745	RESPONSE REGULATOR receiver
GO499_18895	COG2205	protein histidine kinase activity
GO499_18900	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
GO499_18925	COG3038	cytochrome b561
GO499_18935	COG2353	YceI-like domain
GO499_18945	COG1250	3-hydroxyacyl-CoA dehydrogenase
GO499_18980	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
GO499_18985	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
GO499_18985	COG2169	Transcriptional regulator
GO499_18995	COG1028	Short-chain dehydrogenase reductase Sdr
GO499_19000	COG3734	2-keto-3-deoxy-galactonokinase
GO499_19005	COG0800	Aldolase
GO499_19030	COG2198	Histidine kinase
GO499_19030	COG0784	Response regulator, receiver
GO499_19030	COG0643	Histidine kinase
GO499_19035	COG3302	dmso reductase anchor subunit
GO499_19040	COG0437	4 iron, 4 sulfur cluster binding
GO499_19045	COG0596	Alpha beta hydrolase
GO499_19045	COG2945	thiolester hydrolase activity
GO499_19050	COG0243	molybdopterin cofactor binding
GO499_19060	COG2249	NAD(P)H dehydrogenase (quinone) activity
GO499_19065	COG0583	DNA-binding transcription factor activity
GO499_19080	COG3386	PFAM SMP-30 Gluconolaconase
GO499_19085	COG0174	glutamine synthetase
GO499_19090	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GO499_19095	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
GO499_19100	COG3842	ATPase activity
GO499_19105	COG1176	ABC-type spermidine putrescine transport system, permease component I
GO499_19110	COG1177	transmembrane transport
GO499_19115	COG0010	Belongs to the arginase family
GO499_19120	COG0174	glutamine synthetase
GO499_19125	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GO499_19150	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GO499_19160	COG3454	Phosphonate metabolism
GO499_19175	COG0469	pyruvate kinase activity
GO499_19180	COG1522	sequence-specific DNA binding
GO499_19190	COG0291	Belongs to the bacterial ribosomal protein bL35 family
GO499_19195	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
GO499_19245	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
GO499_19260	COG0540	Belongs to the ATCase OTCase family
GO499_19270	COG1573	uracil-dna glycosylase
GO499_19295	COG0521	Mo-molybdopterin cofactor biosynthetic process
GO499_19300	COG0494	nUDIX hydrolase
GO499_19310	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GO499_19325	COG1678	Uncharacterized ACR, COG1678
GO499_19330	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GO499_19335	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
GO499_19335	COG1672	PFAM Archaeal ATPase
GO499_19355	COG3622	Belongs to the hyi family
GO499_19380	COG0154	amidase activity
GO499_19415	COG2205	protein histidine kinase activity
GO499_19420	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
GO499_19425	COG5001	Diguanylate cyclase
GO499_19440	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GO499_19445	COG2264	protein methyltransferase activity
GO499_19455	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
GO499_19460	COG0632	four-way junction helicase activity
GO499_19465	COG2255	four-way junction helicase activity
GO499_19480	COG0824	Thioesterase
GO499_19500	COG0823	Involved in the tonB-independent uptake of proteins
GO499_19505	COG2885	chlorophyll binding
GO499_19515	COG0037	tRNA processing
GO499_19520	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GO499_19530	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
GO499_19540	COG1201	RNA secondary structure unwinding
GO499_19595	COG2885	chlorophyll binding
GO499_19600	COG4964	Belongs to the GSP D family