locus-tag	class	description
AO498_00015	COG0673	inositol 2-dehydrogenase activity
AO498_00020	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AO498_00035	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AO498_00040	COG0248	Ppx GppA phosphatase
AO498_00060	COG1649	PFAM Uncharacterised BCR, COG1649
AO498_00070	COG2211	Major facilitator Superfamily
AO498_00075	COG1472	Belongs to the glycosyl hydrolase 3 family
AO498_00105	COG0488	(ABC) transporter
AO498_00120	COG1418	mRNA catabolic process
AO498_00145	COG2003	Belongs to the UPF0758 family
AO498_00150	COG0268	Binds directly to 16S ribosomal RNA
AO498_00160	COG0436	Aminotransferase
AO498_00165	COG1408	metallophosphoesterase
AO498_00185	COG0488	(ABC) transporter
AO498_00200	COG3279	Response regulator of the LytR AlgR family
AO498_00205	COG3275	phosphorelay sensor kinase activity
AO498_00215	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
AO498_00220	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
AO498_00225	COG1136	(ABC) transporter
AO498_00225	COG0577	efflux transmembrane transporter activity
AO498_00230	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
AO498_00240	COG0745	RESPONSE REGULATOR receiver
AO498_00245	COG5002	protein histidine kinase activity
AO498_00260	COG0564	pseudouridine synthase activity
AO498_00270	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AO498_00275	COG0052	Belongs to the universal ribosomal protein uS2 family
AO498_00280	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
AO498_00285	COG0006	proline dipeptidase activity
AO498_00290	COG0612	Peptidase, M16
AO498_00300	COG1388	LysM domain
AO498_00300	COG1705	Flagellar rod assembly protein muramidase FlgJ
AO498_00315	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
AO498_00320	COG1131	(ABC) transporter
AO498_00350	COG5002	protein histidine kinase activity
AO498_00365	COG0793	Belongs to the peptidase S41A family
AO498_00375	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
AO498_00380	COG0242	peptide deformylase activity
AO498_00385	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AO498_00410	COG3119	arylsulfatase activity
AO498_00450	COG4654	Cytochrome c, class I
AO498_00460	COG0673	inositol 2-dehydrogenase activity
AO498_00465	COG2211	Major facilitator Superfamily
AO498_00500	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
AO498_00520	COG1132	(ABC) transporter
AO498_00530	COG0606	chelatase, subunit chli
AO498_00565	COG2326	polyphosphate kinase activity
AO498_00570	COG1012	belongs to the aldehyde dehydrogenase family
AO498_00585	COG1216	Glycosyl transferase, family 2
AO498_00585	COG1442	glycosyl transferase family 8
AO498_00615	COG0792	nuclease activity
AO498_00620	COG0321	lipoyl(octanoyl) transferase activity
AO498_00635	COG0557	exoribonuclease II activity
AO498_00650	COG4447	cellulose binding
AO498_00655	COG0211	Belongs to the bacterial ribosomal protein bL27 family
AO498_00660	COG0261	This protein binds to 23S rRNA in the presence of protein L20
AO498_00665	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AO498_00670	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AO498_00670	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AO498_00690	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
AO498_00695	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
AO498_00700	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
AO498_00705	COG1805	sodium ion transport
AO498_00715	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
AO498_00720	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
AO498_00725	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
AO498_00730	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
AO498_00740	COG1668	transmembrane transport
AO498_00745	COG4152	abc transporter atp-binding protein
AO498_00755	COG0484	heat shock protein binding
AO498_00760	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AO498_00765	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AO498_00770	COG0563	adenylate kinase activity
AO498_00785	COG2885	chlorophyll binding
AO498_00795	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
AO498_00820	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AO498_00825	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AO498_00825	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AO498_00835	COG0513	Belongs to the DEAD box helicase family
AO498_00855	COG0438	transferase activity, transferring glycosyl groups
AO498_00870	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
AO498_00875	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
AO498_00880	COG1162	GTPase activity
AO498_00885	COG1519	Transferase
AO498_00885	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AO498_00890	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AO498_00905	COG0673	inositol 2-dehydrogenase activity
AO498_00910	COG0527	aspartate kinase activity
AO498_00915	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
AO498_00920	COG2133	pyrroloquinoline quinone binding
AO498_00925	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
AO498_00950	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
AO498_00955	COG0083	homoserine kinase activity
AO498_00960	COG0527	aspartate kinase activity
AO498_00960	COG0460	homoserine dehydrogenase
AO498_00975	COG1028	Short-chain dehydrogenase reductase Sdr
AO498_00985	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AO498_00990	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AO498_01000	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AO498_01020	COG0561	phosphatase activity
AO498_01025	COG1138	Cytochrome C-type biogenesis protein
AO498_01045	COG0820	rRNA (adenine-C2-)-methyltransferase activity
AO498_01070	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
AO498_01080	COG1472	Belongs to the glycosyl hydrolase 3 family
AO498_01090	COG2885	chlorophyll binding
AO498_01100	COG0247	lactate metabolic process
AO498_01100	COG2181	nitrate reductase activity
AO498_01105	COG2181	nitrate reductase activity
AO498_01105	COG0247	lactate metabolic process
AO498_01115	COG1595	DNA-templated transcription, initiation
AO498_01165	COG0475	glutathione-regulated potassium exporter activity
AO498_01170	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
AO498_01175	COG2807	transmembrane transport
AO498_01185	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
AO498_01210	COG0295	cytidine deaminase activity
AO498_01235	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
AO498_01240	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AO498_01240	COG1648	precorrin-2 dehydrogenase activity
AO498_01250	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AO498_01255	COG2895	sulfate adenylyltransferase (ATP) activity
AO498_01260	COG0175	sulfate reduction
AO498_01265	COG0175	sulfate reduction
AO498_01275	COG1959	2 iron, 2 sulfur cluster binding
AO498_01280	COG0326	Molecular chaperone. Has ATPase activity
AO498_01305	COG0438	transferase activity, transferring glycosyl groups
AO498_01310	COG0006	proline dipeptidase activity
AO498_01340	COG0657	acetylesterase activity
AO498_01340	COG2755	lipolytic protein G-D-S-L family
AO498_01345	COG3119	arylsulfatase activity
AO498_01350	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
AO498_01355	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
AO498_01360	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AO498_01365	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AO498_01370	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AO498_01375	COG0356	it plays a direct role in the translocation of protons across the membrane
AO498_01395	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
AO498_01400	COG0322	excinuclease ABC activity
AO498_01420	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AO498_01445	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AO498_01460	COG1366	Belongs to the anti-sigma-factor antagonist family
AO498_01470	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AO498_01475	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AO498_01485	COG1132	(ABC) transporter
AO498_01510	COG1862	Preprotein translocase
AO498_01530	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
AO498_01555	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AO498_01565	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AO498_01570	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AO498_01590	COG1187	pseudouridine synthase activity
AO498_01595	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
AO498_01620	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
AO498_01625	COG1966	Carbon starvation protein
AO498_01650	COG5180	pathogenesis
AO498_01650	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
AO498_01655	COG2251	uridine kinase activity
AO498_01655	COG0195	Participates in both transcription termination and antitermination
AO498_01660	COG0779	Required for maturation of 30S ribosomal subunits
AO498_01670	COG1077	Cell shape determining protein MreB Mrl
AO498_01675	COG1792	Involved in formation and maintenance of cell shape
AO498_01690	COG0772	Belongs to the SEDS family
AO498_01705	COG1435	thymidine kinase activity
AO498_01710	COG1381	Involved in DNA repair and RecF pathway recombination
AO498_01715	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
AO498_01770	COG0564	pseudouridine synthase activity
AO498_01785	COG0556	nucleotide-excision repair
AO498_01800	COG2610	gluconate transmembrane transporter activity
AO498_01810	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
AO498_01820	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AO498_01830	COG0596	Alpha beta hydrolase
AO498_01845	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
AO498_01850	COG0739	heme binding
AO498_01855	COG1187	pseudouridine synthase activity
AO498_01890	COG1595	DNA-templated transcription, initiation
AO498_01905	COG1530	ribonuclease E activity
AO498_01915	COG0776	regulation of translation
AO498_01925	COG0629	single-stranded DNA binding
AO498_01930	COG4535	Mg2 and Co2 transporter CorC
AO498_01935	COG0069	glutamate synthase activity
AO498_01935	COG0070	glutamate synthase
AO498_01935	COG0067	glutamate synthase
AO498_01950	COG1252	NADH dehydrogenase
AO498_01955	COG0217	transcriptional regulatory protein
AO498_01960	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
AO498_01975	COG0038	chloride channel
AO498_01980	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AO498_01985	COG4106	trans-aconitate 2-methyltransferase activity
AO498_02005	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
AO498_02040	COG1283	sodium-dependent phosphate transmembrane transporter activity
AO498_02045	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
AO498_02065	COG0545	Peptidyl-prolyl cis-trans isomerase
AO498_02070	COG0545	Peptidyl-prolyl cis-trans isomerase
AO498_02075	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
AO498_02080	COG0105	UTP biosynthetic process
AO498_02100	COG4206	TonB-dependent receptor
AO498_02100	COG1629	transport
AO498_02110	COG0589	response to stress
AO498_02130	COG1132	(ABC) transporter
AO498_02150	COG4591	ABC-type transport system involved in lipoprotein release permease component
AO498_02155	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
AO498_02175	COG0698	ribose 5-phosphate isomerase
AO498_02180	COG0805	protein transport
AO498_02185	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AO498_02210	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
AO498_02215	COG2154	pterin-4-alpha-carbinolamine dehydratase
AO498_02230	COG1253	flavin adenine dinucleotide binding
AO498_02255	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
AO498_02280	COG0519	Catalyzes the synthesis of GMP from XMP
AO498_02285	COG0788	formyltetrahydrofolate deformylase activity
AO498_02290	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AO498_02300	COG1809	phosphosulfolactate synthase activity
AO498_02310	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AO498_02315	COG4464	protein tyrosine phosphatase activity
AO498_02330	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AO498_02335	COG0232	Belongs to the dGTPase family. Type 2 subfamily
AO498_02345	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AO498_02345	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AO498_02350	COG1956	GAF domain-containing protein
AO498_02355	COG2267	carboxylic ester hydrolase activity
AO498_02360	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
AO498_02375	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AO498_02380	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AO498_02385	COG0038	chloride channel
AO498_02390	COG1090	epimerase
AO498_02440	COG0432	Pfam Uncharacterised protein family UPF0047
AO498_02455	COG0415	Belongs to the DNA photolyase family
AO498_02495	COG0318	PFAM AMP-dependent synthetase and ligase
AO498_02510	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AO498_02530	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
AO498_02535	COG0109	protoheme IX farnesyltransferase activity
AO498_02540	COG0084	hydrolase, TatD family'
AO498_02550	COG0110	maltose O-acetyltransferase activity
AO498_02570	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
AO498_02585	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AO498_02620	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AO498_02625	COG4232	protein-disulfide reductase activity
AO498_02640	COG1473	amidohydrolase
AO498_02650	COG0653	protein targeting
AO498_02655	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
AO498_02660	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
AO498_02680	COG2197	response regulator
AO498_02685	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
AO498_02705	COG1028	Short-chain dehydrogenase reductase Sdr
AO498_02710	COG2318	DinB family
AO498_02730	COG0708	Exodeoxyribonuclease III
AO498_02740	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
AO498_02745	COG0445	tRNA wobble uridine modification
AO498_02760	COG1022	Amp-dependent synthetase and ligase
AO498_02770	COG1250	3-hydroxyacyl-CoA dehydrogenase
AO498_02770	COG1024	Enoyl-CoA hydratase
AO498_02775	COG0183	Belongs to the thiolase family
AO498_02780	COG1960	acyl-CoA dehydrogenase activity
AO498_02785	COG4191	Histidine kinase
AO498_02790	COG2207	Transcriptional regulator
AO498_02790	COG4753	response regulator
AO498_02795	COG2133	pyrroloquinoline quinone binding
AO498_02845	COG0154	amidase activity
AO498_02850	COG3279	Response regulator of the LytR AlgR family
AO498_02855	COG3275	phosphorelay sensor kinase activity
AO498_02880	COG4948	Mandelate Racemase Muconate Lactonizing
AO498_02895	COG0019	diaminopimelate decarboxylase activity
AO498_02915	COG3046	protein related to deoxyribodipyrimidine photolyase
AO498_02930	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
AO498_02935	COG1764	response to oxidative stress
AO498_02950	COG0438	transferase activity, transferring glycosyl groups
AO498_03015	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AO498_03055	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
AO498_03060	COG0157	Belongs to the NadC ModD family
AO498_03070	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
AO498_03080	COG0154	amidase activity
AO498_03090	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AO498_03090	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AO498_03095	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
AO498_03105	COG0463	Glycosyl transferase, family 2
AO498_03115	COG0076	glutamate decarboxylase activity
AO498_03140	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
AO498_03160	COG1595	DNA-templated transcription, initiation
AO498_03185	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
AO498_03190	COG0402	S-adenosylhomocysteine deaminase activity
AO498_03205	COG3279	Response regulator of the LytR AlgR family
AO498_03210	COG4191	Histidine kinase
AO498_03220	COG3852	Histidine kinase
AO498_03235	COG1764	response to oxidative stress
AO498_03240	COG1846	Transcriptional regulator
AO498_03245	COG0673	inositol 2-dehydrogenase activity
AO498_03250	COG0583	DNA-binding transcription factor activity
AO498_03285	COG1968	undecaprenyl-diphosphatase activity
AO498_03295	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
AO498_03300	COG1845	cytochrome c oxidase, subunit III
AO498_03320	COG1704	LemA family
AO498_03340	COG0149	triose-phosphate isomerase activity
AO498_03345	COG2264	protein methyltransferase activity
AO498_03355	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
AO498_03355	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
AO498_03360	COG1137	ATPase activity
AO498_03375	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
AO498_03380	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AO498_03385	COG3275	phosphorelay sensor kinase activity
AO498_03390	COG3279	Response regulator of the LytR AlgR family
AO498_03395	COG0784	Response regulator, receiver
AO498_03400	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
AO498_03410	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
AO498_03415	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AO498_03465	COG2226	methyltransferase
AO498_03485	COG1187	pseudouridine synthase activity
AO498_03490	COG0714	Associated with various cellular activities
AO498_03500	COG4412	M6 family metalloprotease domain protein
AO498_03500	COG1404	Belongs to the peptidase S8 family
AO498_03530	COG1215	transferase activity, transferring glycosyl groups
AO498_03550	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
AO498_03555	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
AO498_03600	COG0668	transmembrane transport
AO498_03620	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
AO498_03625	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
AO498_03630	COG3177	Filamentation induced by cAMP protein fic
AO498_03635	COG1473	amidohydrolase
AO498_03660	COG0423	glycine-tRNA ligase activity
AO498_03670	COG0673	inositol 2-dehydrogenase activity
AO498_03680	COG4585	Histidine kinase
AO498_03695	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AO498_03705	COG0572	uridine kinase
AO498_03710	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
AO498_03770	COG0242	peptide deformylase activity
AO498_03775	COG0488	(ABC) transporter
AO498_03810	COG0284	orotidine-5'-phosphate decarboxylase activity
AO498_03825	COG4974	Belongs to the 'phage' integrase family
AO498_03830	COG0828	Belongs to the bacterial ribosomal protein bS21 family
AO498_03840	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
AO498_03845	COG0791	NLP P60 protein
AO498_03860	COG1506	peptidase
AO498_03860	COG0823	Involved in the tonB-independent uptake of proteins
AO498_03865	COG1181	Belongs to the D-alanine--D-alanine ligase family
AO498_03875	COG1611	Belongs to the LOG family
AO498_03895	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
AO498_03905	COG1960	acyl-CoA dehydrogenase activity
AO498_03920	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
AO498_03925	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
AO498_03930	COG0297	glycogen (starch) synthase activity
AO498_03940	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AO498_04030	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
AO498_04040	COG0626	cystathionine gamma-synthase activity
AO498_04055	COG0515	serine threonine protein kinase
AO498_04055	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AO498_04060	COG0673	inositol 2-dehydrogenase activity
AO498_04065	COG3622	Belongs to the hyi family
AO498_04075	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
AO498_04085	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AO498_04095	COG1104	cysteine desulfurase activity
AO498_04100	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AO498_04110	COG3956	TIGRFAM MazG family protein
AO498_04115	COG0251	oxidation-reduction process
AO498_04140	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AO498_04155	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AO498_04165	COG0527	aspartate kinase activity
AO498_04170	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
AO498_04180	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
AO498_04185	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AO498_04200	COG0347	Belongs to the P(II) protein family
AO498_04205	COG0004	ammonium transporteR
AO498_04215	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
AO498_04225	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
AO498_04230	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
AO498_04255	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
AO498_04255	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AO498_04265	COG0335	large ribosomal subunit rRNA binding
AO498_04270	COG0336	Belongs to the RNA methyltransferase TrmD family
AO498_04275	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
AO498_04280	COG0228	four-way junction DNA binding
AO498_04350	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AO498_04355	COG3938	Belongs to the proline racemase family
AO498_04365	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AO498_04400	COG1595	DNA-templated transcription, initiation
AO498_04430	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AO498_04440	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
AO498_04445	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
AO498_04460	COG1160	GTP binding
AO498_04465	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AO498_04485	COG2890	protein-(glutamine-N5) methyltransferase activity
AO498_04490	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AO498_04490	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AO498_04495	COG0517	IMP dehydrogenase activity
AO498_04495	COG0516	GMP reductase activity
AO498_04500	COG0167	dihydroorotate dehydrogenase activity
AO498_04505	COG1674	ftsk spoiiie
AO498_04520	COG1610	YqeY-like protein
AO498_04525	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
AO498_04530	COG0596	Alpha beta hydrolase
AO498_04535	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
AO498_04540	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
AO498_04575	COG1609	Transcriptional regulator
AO498_04580	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
AO498_04585	COG1063	alcohol dehydrogenase
AO498_04605	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
AO498_04610	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
AO498_04630	COG2176	DNA-directed DNA polymerase activity
AO498_04630	COG5002	protein histidine kinase activity
AO498_04645	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AO498_04665	COG2255	four-way junction helicase activity
AO498_04670	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AO498_04675	COG3844	kynureninase activity
AO498_04680	COG0662	Cupin 2, conserved barrel domain protein
AO498_04695	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
AO498_04700	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AO498_04705	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
AO498_04710	COG1349	DNA-binding transcription factor activity
AO498_04730	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
AO498_04735	COG0492	ferredoxin-NADP+ reductase activity
AO498_04745	COG1902	pentaerythritol trinitrate reductase activity
AO498_04780	COG2001	Belongs to the MraZ family
AO498_04785	COG0275	rRNA processing
AO498_04795	COG0768	penicillin binding
AO498_04800	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AO498_04805	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AO498_04810	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
AO498_04820	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AO498_04825	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AO498_04840	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AO498_04845	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
AO498_04900	COG0218	Necessary for normal cell division and for the maintenance of normal septation
AO498_04905	COG2226	methyltransferase
AO498_04915	COG4145	pantothenate transmembrane transporter activity
AO498_04925	COG1902	pentaerythritol trinitrate reductase activity
AO498_04930	COG1028	Short-chain dehydrogenase reductase Sdr
AO498_04955	COG1629	transport
AO498_04955	COG4206	TonB-dependent receptor
AO498_04990	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
AO498_04995	COG0194	GDP metabolic process
AO498_05005	COG1595	DNA-templated transcription, initiation
AO498_05025	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AO498_05035	COG0129	dihydroxy-acid dehydratase activity
AO498_05040	COG1028	Short-chain dehydrogenase reductase Sdr
AO498_05050	COG1028	Short-chain dehydrogenase reductase Sdr
AO498_05060	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AO498_05095	COG1523	belongs to the glycosyl hydrolase 13 family
AO498_05105	COG1073	alpha beta
AO498_05120	COG0346	lactoylglutathione lyase activity
AO498_05130	COG4628	conserved protein (DUF2132)
AO498_05135	COG0592	DNA-directed DNA polymerase activity
AO498_05150	COG1131	(ABC) transporter
AO498_05155	COG0328	RNA-DNA hybrid ribonuclease activity
AO498_05160	COG2095	MarC family integral membrane protein
AO498_05170	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AO498_05180	COG1574	metal-dependent hydrolase with the TIM-barrel fold
AO498_05190	COG0823	Involved in the tonB-independent uptake of proteins
AO498_05190	COG1506	peptidase
AO498_05195	COG1960	acyl-CoA dehydrogenase activity
AO498_05200	COG4585	Histidine kinase
AO498_05225	COG4221	oxidoreductase activity
AO498_05230	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
AO498_05240	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
AO498_05255	COG0697	spore germination
AO498_05260	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AO498_05280	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AO498_05285	COG0688	phosphatidylethanolamine metabolic process
AO498_05300	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
AO498_05310	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
AO498_05315	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
AO498_05345	COG0508	dehydrogenase complex catalyzes the overall conversion of
AO498_05405	COG0542	response to heat
AO498_05410	COG0259	pyridoxamine-phosphate oxidase activity
AO498_05415	COG0233	cytoplasmic translational termination
AO498_05420	COG0528	UMP kinase activity
AO498_05425	COG4770	biotin carboxylase activity
AO498_05470	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
AO498_05475	COG0081	regulation of translation
AO498_05480	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
AO498_05485	COG0222	ribosome binding
AO498_05490	COG0085	RNA polymerase activity
AO498_05495	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AO498_05505	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
AO498_05510	COG0049	tRNA binding
AO498_05515	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AO498_05520	COG0051	transcription antitermination factor activity, RNA binding
AO498_05525	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
AO498_05530	COG0088	Forms part of the polypeptide exit tunnel
AO498_05535	COG0089	rRNA binding
AO498_05540	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
AO498_05545	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AO498_05550	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
AO498_05555	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
AO498_05560	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
AO498_05565	COG0255	Belongs to the universal ribosomal protein uL29 family
AO498_05570	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
AO498_05575	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
AO498_05580	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
AO498_05585	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
AO498_05590	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
AO498_05595	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
AO498_05600	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
AO498_05605	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
AO498_05610	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
AO498_05615	COG1841	ribosomal large subunit assembly
AO498_05620	COG0200	Binds to the 23S rRNA
AO498_05625	COG0201	protein transport
AO498_05635	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
AO498_05640	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
AO498_05645	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
AO498_05650	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
AO498_05655	COG0202	RNA polymerase activity
AO498_05660	COG0203	ribosomal protein L17
AO498_05665	COG0505	Belongs to the CarA family
AO498_05670	COG0148	phosphopyruvate hydratase activity
AO498_05685	COG1045	serine acetyltransferase
AO498_05730	COG0039	L-malate dehydrogenase activity
AO498_05740	COG0037	tRNA processing
AO498_05775	COG0497	DNA recombination
AO498_05780	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
AO498_05785	COG1228	amidohydrolase
AO498_05790	COG0596	Alpha beta hydrolase
AO498_05810	COG1846	Transcriptional regulator
AO498_05815	COG2353	YceI-like domain
AO498_05820	COG0346	lactoylglutathione lyase activity
AO498_05830	COG0419	ATPase involved in DNA repair
AO498_05835	COG0420	3'-5' exonuclease activity
AO498_05837	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
AO498_05885	COG2010	Cytochrome c
AO498_05885	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AO498_05890	COG1473	amidohydrolase
AO498_05945	COG1082	Xylose isomerase domain protein TIM barrel
AO498_05955	COG3609	addiction module antidote protein, CC2985 family
AO498_05975	COG2759	Belongs to the formate--tetrahydrofolate ligase family
AO498_05995	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AO498_06010	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
AO498_06015	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
AO498_06020	COG0673	inositol 2-dehydrogenase activity
AO498_06075	COG0363	glucosamine-6-phosphate deaminase activity
AO498_06085	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
AO498_06090	COG2205	protein histidine kinase activity
AO498_06090	COG0784	Response regulator, receiver
AO498_06095	COG5002	protein histidine kinase activity
AO498_06100	COG1136	(ABC) transporter
AO498_06105	COG1136	(ABC) transporter
AO498_06105	COG0577	efflux transmembrane transporter activity
AO498_06130	COG1999	signal sequence binding
AO498_06145	COG1703	isobutyryl-CoA mutase activity
AO498_06150	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AO498_06155	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AO498_06160	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AO498_06160	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AO498_06180	COG2851	Citrate transporter
AO498_06205	COG0633	Ferredoxin
AO498_06210	COG0492	ferredoxin-NADP+ reductase activity
AO498_06215	COG1846	Transcriptional regulator
AO498_06275	COG1295	ribonuclease BN
AO498_06285	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
AO498_06290	COG0494	nUDIX hydrolase
AO498_06295	COG0009	L-threonylcarbamoyladenylate synthase
AO498_06305	COG0542	response to heat
AO498_06320	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
AO498_06330	COG1695	Transcriptional regulator
AO498_06350	COG0626	cystathionine gamma-synthase activity
AO498_06360	COG1193	negative regulation of DNA recombination
AO498_06365	COG0415	Belongs to the DNA photolyase family
AO498_06375	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
AO498_06380	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
AO498_06400	COG3842	ATPase activity
AO498_06410	COG4106	trans-aconitate 2-methyltransferase activity
AO498_06420	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
AO498_06425	COG0590	tRNA wobble adenosine to inosine editing
AO498_06430	COG3279	Response regulator of the LytR AlgR family
AO498_06435	COG3275	phosphorelay sensor kinase activity
AO498_06445	COG0508	dehydrogenase complex catalyzes the overall conversion of
AO498_06445	COG0022	dehydrogenase e1 component
AO498_06450	COG1012	belongs to the aldehyde dehydrogenase family
AO498_06465	COG0124	histidyl-tRNA synthetase
AO498_06495	COG4206	TonB-dependent receptor
AO498_06495	COG1629	transport
AO498_06515	COG1446	asparaginase
AO498_06520	COG3142	Participates in the control of copper homeostasis
AO498_06530	COG0517	IMP dehydrogenase activity
AO498_06540	COG0193	aminoacyl-tRNA hydrolase activity
AO498_06545	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
AO498_06550	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AO498_06580	COG0359	binds to the 23S rRNA
AO498_06585	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
AO498_06590	COG0360	Binds together with S18 to 16S ribosomal RNA
AO498_06600	COG0500	methyltransferase
AO498_06615	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
AO498_06620	COG0681	Belongs to the peptidase S26 family
AO498_06625	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
AO498_06635	COG1475	DNA binding
AO498_06640	COG1192	Involved in chromosome partitioning
AO498_06645	COG0706	membrane insertase activity
AO498_06650	COG0504	CTP synthase activity
AO498_06685	COG1404	Belongs to the peptidase S8 family
AO498_06695	COG2884	Cell division ATP-binding protein ftsE
AO498_06705	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AO498_06760	COG0251	oxidation-reduction process
AO498_06775	COG3264	Mechanosensitive ion channel
AO498_06775	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
AO498_06780	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AO498_06780	COG3153	acetyltransferase
AO498_06785	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
AO498_06790	COG2877	3-deoxy-8-phosphooctulonate synthase activity
AO498_06810	COG0302	gtp cyclohydrolase
AO498_06815	COG1028	Short-chain dehydrogenase reductase Sdr
AO498_06835	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
AO498_06835	COG1793	dna ligase
AO498_06840	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AO498_06840	COG0519	Catalyzes the synthesis of GMP from XMP
AO498_06850	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AO498_06855	COG1393	Belongs to the ArsC family
AO498_06875	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AO498_06880	COG0156	8-amino-7-oxononanoate synthase activity
AO498_06885	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
AO498_06890	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AO498_06905	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
AO498_06920	COG0442	prolyl-tRNA aminoacylation
AO498_06930	COG4864	UPF0365 protein
AO498_06940	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
AO498_06970	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AO498_06980	COG1215	transferase activity, transferring glycosyl groups
AO498_07020	COG0673	inositol 2-dehydrogenase activity
AO498_07035	COG2808	Putative FMN-binding domain
AO498_07040	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AO498_07040	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AO498_07065	COG0657	acetylesterase activity
AO498_07065	COG2755	lipolytic protein G-D-S-L family
AO498_07105	COG1120	ATPase activity
AO498_07110	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AO498_07135	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AO498_07140	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
AO498_07160	COG5002	protein histidine kinase activity
AO498_07165	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
AO498_07170	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
AO498_07175	COG1028	Short-chain dehydrogenase reductase Sdr
AO498_07180	COG0588	phosphoglycerate mutase activity
AO498_07185	COG1278	Cold shock
AO498_07190	COG0071	Belongs to the small heat shock protein (HSP20) family
AO498_07205	COG5002	protein histidine kinase activity
AO498_07210	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AO498_07215	COG3250	beta-galactosidase activity
AO498_07215	COG5297	Belongs to the glycosyl hydrolase family 6
AO498_07220	COG0477	Major facilitator Superfamily
AO498_07235	COG3254	rhamnose metabolic process
AO498_07240	COG1082	Xylose isomerase domain protein TIM barrel
AO498_07245	COG1063	alcohol dehydrogenase
AO498_07250	COG0667	Aldo Keto reductase
AO498_07260	COG2205	protein histidine kinase activity
AO498_07260	COG5002	protein histidine kinase activity
AO498_07260	COG0784	Response regulator, receiver
AO498_07280	COG1476	TRANSCRIPTIONal
AO498_07305	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AO498_07305	COG2205	protein histidine kinase activity
AO498_07310	COG0135	phosphoribosylanthranilate isomerase activity
AO498_07315	COG1051	belongs to the nudix hydrolase family
AO498_07330	COG0047	phosphoribosylformylglycinamidine synthase activity
AO498_07330	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AO498_07370	COG1570	exodeoxyribonuclease VII activity
AO498_07375	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AO498_07390	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AO498_07395	COG1309	transcriptional regulator
AO498_07400	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AO498_07400	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AO498_07410	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AO498_07415	COG2308	Evidence 4 Homologs of previously reported genes of
AO498_07460	COG0745	RESPONSE REGULATOR receiver
AO498_07465	COG5002	protein histidine kinase activity
AO498_07510	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AO498_07520	COG0531	amino acid
AO498_07525	COG0857	belongs to the CobB CobQ family
AO498_07525	COG0280	phosphate acetyltransferase
AO498_07530	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AO498_07585	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
AO498_07590	COG0531	amino acid
AO498_07605	COG0436	Aminotransferase
AO498_07610	COG1605	Chorismate mutase
AO498_07610	COG0077	Prephenate dehydratase
AO498_07615	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
AO498_07620	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
AO498_07625	COG2877	3-deoxy-8-phosphooctulonate synthase activity
AO498_07635	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
AO498_07660	COG0860	N-Acetylmuramoyl-L-alanine amidase
AO498_07665	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AO498_07715	COG0316	Belongs to the HesB IscA family
AO498_07740	COG1490	D-aminoacyl-tRNA deacylase activity
AO498_07745	COG3119	arylsulfatase activity
AO498_07750	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
AO498_07755	COG0346	lactoylglutathione lyase activity
AO498_07760	COG0316	Belongs to the HesB IscA family
AO498_07765	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AO498_07770	COG2045	Belongs to the ComB family
AO498_07785	COG0667	Aldo Keto reductase
AO498_07795	COG0385	Bile acid
AO498_07845	COG1012	belongs to the aldehyde dehydrogenase family
AO498_07860	COG0450	alkyl hydroperoxide reductase
AO498_07875	COG1294	oxidase, subunit
AO498_07880	COG1271	oxidase subunit
AO498_07900	COG0495	leucyl-tRNA aminoacylation
AO498_07915	COG0602	queuosine metabolic process
AO498_07920	COG2885	chlorophyll binding
AO498_07930	COG1629	transport
AO498_07930	COG4206	TonB-dependent receptor
AO498_07960	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AO498_07965	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
AO498_07970	COG0740	serine-type endopeptidase activity
AO498_07975	COG0544	peptidyl-prolyl cis-trans isomerase activity
AO498_07985	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AO498_07990	COG0735	belongs to the Fur family
AO498_07995	COG1366	Belongs to the anti-sigma-factor antagonist family
AO498_08000	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AO498_08035	COG2217	Heavy metal translocating P-type atpase
AO498_08060	COG0348	domain, Protein
AO498_08075	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AO498_08085	COG2304	oxidoreductase activity
AO498_08105	COG1193	negative regulation of DNA recombination
AO498_08115	COG4133	protoheme IX ABC transporter activity
AO498_08120	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AO498_08125	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
AO498_08125	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AO498_08130	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AO498_08135	COG1078	dGTPase activity
AO498_08145	COG0802	atpase or kinase
AO498_08150	COG0686	Belongs to the AlaDH PNT family
AO498_08200	COG0513	Belongs to the DEAD box helicase family
AO498_08215	COG1028	Short-chain dehydrogenase reductase Sdr
AO498_08240	COG3174	membrane
AO498_08290	COG4807	Protein conserved in bacteria
AO498_08325	COG0481	GTPase activity
AO498_08335	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AO498_08355	COG1363	Peptidase, m42
AO498_08365	COG2205	protein histidine kinase activity
AO498_08380	COG0525	valine-tRNA ligase activity
AO498_08425	COG1115	amino acid carrier protein
AO498_08465	COG2382	esterase
AO498_08465	COG3693	PFAM glycoside hydrolase, family 10
AO498_08470	COG2382	esterase
AO498_08480	COG1121	(ABC) transporter
AO498_08485	COG2382	esterase
AO498_08500	COG2272	Belongs to the type-B carboxylesterase lipase family
AO498_08505	COG1136	(ABC) transporter
AO498_08510	COG1136	(ABC) transporter
AO498_08510	COG0577	efflux transmembrane transporter activity
AO498_08550	COG1774	PSP1 C-terminal conserved region
AO498_08560	COG0514	ATP-dependent DNA helicase (RecQ)
AO498_08565	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
AO498_08565	COG0517	IMP dehydrogenase activity
AO498_08570	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
AO498_08570	COG0662	Cupin 2, conserved barrel domain protein
AO498_08585	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AO498_08595	COG3118	belongs to the thioredoxin family
AO498_08600	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AO498_08600	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AO498_08630	COG3258	Cytochrome c
AO498_08640	COG3239	Fatty acid desaturase
AO498_08645	COG0513	Belongs to the DEAD box helicase family
AO498_08660	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AO498_08705	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AO498_08705	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AO498_08725	COG1104	cysteine desulfurase activity
AO498_08730	COG4191	Histidine kinase
AO498_08735	COG2204	response regulator
AO498_08760	COG0577	efflux transmembrane transporter activity
AO498_08770	COG1136	(ABC) transporter
AO498_08770	COG0577	efflux transmembrane transporter activity
AO498_08780	COG0577	efflux transmembrane transporter activity
AO498_08785	COG0577	efflux transmembrane transporter activity
AO498_08800	COG0673	inositol 2-dehydrogenase activity
AO498_08805	COG0577	efflux transmembrane transporter activity
AO498_08810	COG1136	(ABC) transporter
AO498_08810	COG0577	efflux transmembrane transporter activity
AO498_08825	COG1331	Highly conserved protein containing a thioredoxin domain
AO498_08830	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
AO498_08850	COG0469	pyruvate kinase activity
AO498_08870	COG0673	inositol 2-dehydrogenase activity
AO498_08875	COG0823	Involved in the tonB-independent uptake of proteins
AO498_08910	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AO498_08915	COG0303	'Molybdopterin
AO498_08935	COG0314	molybdopterin synthase activity
AO498_08960	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AO498_08965	COG2183	response to ionizing radiation
AO498_08970	COG1629	transport
AO498_08970	COG4206	TonB-dependent receptor
AO498_08980	COG3620	sequence-specific DNA binding
AO498_09015	COG0010	Belongs to the arginase family
AO498_09020	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
AO498_09030	COG2986	histidine ammonia-lyase
AO498_09035	COG0583	DNA-binding transcription factor activity
AO498_09040	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
AO498_09045	COG1169	isochorismate synthase
AO498_09050	COG2050	protein possibly involved in aromatic compounds catabolism
AO498_09055	COG0406	alpha-ribazole phosphatase activity
AO498_09070	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AO498_09075	COG1663	tetraacyldisaccharide 4'-kinase activity
AO498_09090	COG1136	(ABC) transporter
AO498_09090	COG0577	efflux transmembrane transporter activity
AO498_09110	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
AO498_09125	COG3119	arylsulfatase activity
AO498_09135	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
AO498_09140	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AO498_09150	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
AO498_09155	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AO498_09170	COG1228	amidohydrolase
AO498_09190	COG0459	protein refolding
AO498_09195	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
AO498_09230	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AO498_09235	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AO498_09245	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
AO498_09265	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
AO498_09280	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
AO498_09285	COG1051	belongs to the nudix hydrolase family
AO498_09290	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
AO498_09310	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AO498_09320	COG1132	(ABC) transporter
AO498_09330	COG2205	protein histidine kinase activity
AO498_09335	COG3279	Response regulator of the LytR AlgR family
AO498_09340	COG0784	Response regulator, receiver
AO498_09345	COG0697	spore germination
AO498_09350	COG0456	acetyltransferase
AO498_09370	COG1607	acyl-coa hydrolase
AO498_09375	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
AO498_09405	COG4821	SIS domain
AO498_09425	COG0439	Biotin carboxylase
AO498_09430	COG0511	ligase activity, forming carbon-carbon bonds
AO498_09435	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AO498_09440	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AO498_09442	COG0333	Belongs to the bacterial ribosomal protein bL32 family
AO498_09450	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
AO498_09455	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AO498_09460	COG2239	Acts as a magnesium transporter
AO498_09465	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AO498_09470	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AO498_09495	COG1322	Protein conserved in bacteria
AO498_09500	COG0569	domain protein
AO498_09505	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AO498_09510	COG1201	RNA secondary structure unwinding
AO498_09515	COG1793	dna ligase
AO498_09540	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
AO498_09550	COG0488	(ABC) transporter
AO498_09565	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AO498_09570	COG1321	iron dependent repressor
AO498_09575	COG4771	TonB-dependent receptor
AO498_09590	COG1760	l-serine dehydratase
AO498_09600	COG1070	Carbohydrate kinase
AO498_09605	COG2115	Belongs to the xylose isomerase family
AO498_09640	COG1960	acyl-CoA dehydrogenase activity
AO498_09645	COG0318	PFAM AMP-dependent synthetase and ligase
AO498_09660	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AO498_09675	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AO498_09680	COG1127	ABC transporter
AO498_09690	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AO498_09695	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AO498_09700	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AO498_09740	COG0714	Associated with various cellular activities
AO498_09780	COG0793	Belongs to the peptidase S41A family
AO498_09780	COG4946	Tricorn protease homolog
AO498_09790	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
AO498_09800	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AO498_09830	COG1619	proteins homologs of microcin C7 resistance protein MccF
AO498_09845	COG2267	carboxylic ester hydrolase activity
AO498_09855	COG2363	Small membrane protein
AO498_09865	COG1280	lysine exporter protein (LysE YggA)
AO498_09875	COG2824	Alkylphosphonate utilization operon protein PhnA
AO498_09880	COG0686	Belongs to the AlaDH PNT family
AO498_09885	COG0022	dehydrogenase e1 component
AO498_09900	COG2204	response regulator
AO498_09925	COG0589	response to stress
AO498_09930	COG1575	Belongs to the MenA family. Type 1 subfamily
AO498_09935	COG0386	Belongs to the glutathione peroxidase family
AO498_09940	COG0018	arginyl-trna synthetase
AO498_09945	COG0010	Belongs to the arginase family
AO498_09970	COG1960	acyl-CoA dehydrogenase activity
AO498_09975	COG1312	Catalyzes the dehydration of D-mannonate
AO498_09980	COG1028	Short-chain dehydrogenase reductase Sdr
AO498_09985	COG1904	glucuronate isomerase
AO498_09990	COG1609	Transcriptional regulator
AO498_09995	COG0561	phosphatase activity
AO498_10000	COG4206	TonB-dependent receptor
AO498_10000	COG1629	transport
AO498_10005	COG0673	inositol 2-dehydrogenase activity
AO498_10015	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
AO498_10015	COG0116	Belongs to the methyltransferase superfamily
AO498_10050	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AO498_10060	COG0745	RESPONSE REGULATOR receiver
AO498_10095	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AO498_10120	COG1473	amidohydrolase
AO498_10125	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
AO498_10140	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
AO498_10150	COG1477	protein flavinylation
AO498_10175	COG2885	chlorophyll binding
AO498_10185	COG0183	Belongs to the thiolase family
AO498_10200	COG2304	oxidoreductase activity
AO498_10205	COG4206	TonB-dependent receptor
AO498_10235	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AO498_10265	COG1088	dTDP-glucose 4,6-dehydratase activity
AO498_10270	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AO498_10300	COG1132	(ABC) transporter
AO498_10315	COG0246	Mannitol dehydrogenase
AO498_10330	COG2721	sulfolactate sulfo-lyase activity
AO498_10335	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AO498_10345	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AO498_10350	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
AO498_10360	COG0450	alkyl hydroperoxide reductase
AO498_10390	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AO498_10415	COG0180	Tryptophanyl-tRNA synthetase
AO498_10445	COG0673	inositol 2-dehydrogenase activity
AO498_10460	COG0656	L-ascorbic acid biosynthetic process
AO498_10480	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AO498_10495	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AO498_10525	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AO498_10560	COG0811	peptide transport
AO498_10565	COG0848	biopolymer transport protein
AO498_10580	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AO498_10585	COG1250	3-hydroxyacyl-CoA dehydrogenase
AO498_10600	COG1028	Short-chain dehydrogenase reductase Sdr
AO498_10605	COG1063	alcohol dehydrogenase
AO498_10615	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
AO498_10620	COG1309	transcriptional regulator
AO498_10625	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AO498_10640	COG0569	domain protein
AO498_10645	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AO498_10670	COG0123	including yeast histone deacetylase and acetoin utilization protein
AO498_10685	COG3047	cAMP biosynthetic process
AO498_10685	COG2885	chlorophyll binding
AO498_10700	COG1115	amino acid carrier protein
AO498_10705	COG1929	Belongs to the glycerate kinase type-1 family
AO498_10745	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AO498_10755	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AO498_10765	COG3250	beta-galactosidase activity
AO498_10775	COG2217	Heavy metal translocating P-type atpase
AO498_10785	COG0642	Histidine kinase
AO498_10810	COG4946	Tricorn protease homolog
AO498_10810	COG1506	peptidase
AO498_10810	COG0823	Involved in the tonB-independent uptake of proteins
AO498_10815	COG2197	response regulator
AO498_10865	COG1196	nuclear chromosome segregation
AO498_10875	COG0723	plastoquinol--plastocyanin reductase activity
AO498_10945	COG1643	Atp-dependent helicase
AO498_10955	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AO498_10965	COG0305	Participates in initiation and elongation during chromosome replication
AO498_10970	COG0604	alcohol dehydrogenase
AO498_10985	COG2086	electron transfer activity
AO498_10990	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
AO498_11000	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AO498_11010	COG0564	pseudouridine synthase activity
AO498_11015	COG0482	sulfurtransferase activity
AO498_11020	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
AO498_11060	COG3185	4-Hydroxyphenylpyruvate dioxygenase
AO498_11080	COG0598	Magnesium transport protein CorA
AO498_11090	COG2814	Major facilitator Superfamily
AO498_11100	COG1960	acyl-CoA dehydrogenase activity
AO498_11115	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AO498_11125	COG0659	secondary active sulfate transmembrane transporter activity
AO498_11130	COG0165	Argininosuccinate lyase
AO498_11140	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AO498_11150	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AO498_11155	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
AO498_11160	COG0137	argininosuccinate synthase activity
AO498_11170	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AO498_11180	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
AO498_11195	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
AO498_11200	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
AO498_11220	COG0436	Aminotransferase
AO498_11240	COG3275	phosphorelay sensor kinase activity
AO498_11245	COG3279	Response regulator of the LytR AlgR family
AO498_11250	COG0405	Gamma-glutamyltransferase
AO498_11275	COG1428	Deoxynucleoside kinase
AO498_11280	COG1250	3-hydroxyacyl-CoA dehydrogenase
AO498_11285	COG2996	Protein conserved in bacteria
AO498_11335	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AO498_11340	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
AO498_11345	COG3104	oligopeptide transport
AO498_11360	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
AO498_11365	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
AO498_11370	COG0196	riboflavin kinase activity
AO498_11375	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AO498_11385	COG2177	Part of the ABC transporter FtsEX involved in
AO498_11410	COG0513	Belongs to the DEAD box helicase family
AO498_11415	COG3409	Peptidoglycan-binding domain 1 protein
AO498_11415	COG3773	Cell wall hydrolase
AO498_11425	COG0531	amino acid
AO498_11445	COG0156	8-amino-7-oxononanoate synthase activity
AO498_11450	COG0439	Biotin carboxylase
AO498_11460	COG0424	maF-like protein
AO498_11470	COG2340	Cysteine-rich secretory protein family
AO498_11475	COG0668	transmembrane transport
AO498_11490	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AO498_11505	COG1621	beta-fructofuranosidase activity
AO498_11510	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
AO498_11540	COG0363	glucosamine-6-phosphate deaminase activity
AO498_11590	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
AO498_11600	COG1401	restriction endodeoxyribonuclease activity
AO498_11610	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
AO498_11655	COG4974	Belongs to the 'phage' integrase family
AO498_11665	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
AO498_11675	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AO498_11680	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AO498_11680	COG1321	iron dependent repressor
AO498_11685	COG1121	(ABC) transporter
AO498_11690	COG0803	Belongs to the bacterial solute-binding protein 9 family
AO498_11705	COG2171	N-acyltransferase activity
AO498_11725	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
AO498_11755	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
AO498_11760	COG0673	inositol 2-dehydrogenase activity
AO498_11785	COG3590	peptidase
AO498_11805	COG0471	metal ion transport
AO498_11810	COG3275	phosphorelay sensor kinase activity
AO498_11815	COG3279	Response regulator of the LytR AlgR family
AO498_11820	COG0662	Cupin 2, conserved barrel domain protein
AO498_11820	COG2207	Transcriptional regulator
AO498_11825	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
AO498_11840	COG0673	inositol 2-dehydrogenase activity
AO498_11875	COG1678	Uncharacterized ACR, COG1678
AO498_11880	COG0259	pyridoxamine-phosphate oxidase activity
AO498_11890	COG1196	nuclear chromosome segregation
AO498_11890	COG0741	lytic transglycosylase activity
AO498_11890	COG0739	heme binding
AO498_11895	COG0492	ferredoxin-NADP+ reductase activity
AO498_11900	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AO498_11905	COG1185	polyribonucleotide nucleotidyltransferase activity
AO498_11910	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
AO498_11930	COG2827	Endonuclease containing a URI domain
AO498_11940	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
AO498_11945	COG0291	Belongs to the bacterial ribosomal protein bL35 family
AO498_11950	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
AO498_11955	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AO498_11965	COG0579	oxidoreductase
AO498_11980	COG2081	HI0933 family
AO498_11985	COG0433	COG0433 Predicted ATPase
AO498_11990	COG1104	cysteine desulfurase activity
AO498_11995	COG1733	regulation of RNA biosynthetic process
AO498_12000	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
AO498_12005	COG1028	Short-chain dehydrogenase reductase Sdr
AO498_12030	COG0673	inositol 2-dehydrogenase activity
AO498_12055	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AO498_12070	COG0384	phenazine biosynthesis protein PhzF
AO498_12085	COG1528	Iron-storage protein
AO498_12095	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AO498_12110	COG1752	Esterase of the alpha-beta hydrolase superfamily
AO498_12115	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AO498_12120	COG0825	malonyl-CoA metabolic process
AO498_12135	COG0363	glucosamine-6-phosphate deaminase activity
AO498_12140	COG0513	Belongs to the DEAD box helicase family
AO498_12155	COG0758	DNA mediated transformation
AO498_12175	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
AO498_12180	COG1410	methionine synthase
AO498_12180	COG0646	methionine synthase
AO498_12195	COG2205	protein histidine kinase activity
AO498_12195	COG0784	Response regulator, receiver
AO498_12200	COG0393	Putative heavy-metal-binding
AO498_12215	COG0494	nUDIX hydrolase
AO498_12225	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
AO498_12235	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AO498_12255	COG1388	LysM domain
AO498_12255	COG0791	NLP P60 protein
AO498_12260	COG1030	water channel activity
AO498_12275	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AO498_12285	COG1136	(ABC) transporter
AO498_12290	COG2096	Adenosyltransferase
AO498_12295	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AO498_12305	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
AO498_12310	COG2814	Major facilitator Superfamily
AO498_12320	COG0534	Mate efflux family protein
AO498_12330	COG1522	sequence-specific DNA binding
AO498_12345	COG0415	Belongs to the DNA photolyase family
AO498_12355	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AO498_12370	COG0730	response to heat
AO498_12375	COG0589	response to stress
AO498_12445	COG1770	oligopeptidase
AO498_12450	COG1803	Methylglyoxal synthase
AO498_12455	COG0205	6-phosphofructokinase activity
AO498_12465	COG0191	fructose-bisphosphate aldolase activity
AO498_12470	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
AO498_12480	COG1609	Transcriptional regulator
AO498_12500	COG2205	protein histidine kinase activity
AO498_12505	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
AO498_12515	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AO498_12515	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AO498_12520	COG0358	DNA primase activity
AO498_12525	COG0489	protein tyrosine kinase activity
AO498_12530	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
AO498_12540	COG0515	serine threonine protein kinase
AO498_12540	COG2815	serine threonine protein kinase
AO498_12550	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AO498_12575	COG1011	Hydrolase
AO498_12605	COG0659	secondary active sulfate transmembrane transporter activity
AO498_12610	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AO498_12615	COG3002	Belongs to the UPF0753 family
AO498_12625	COG2329	Antibiotic biosynthesis monooxygenase
AO498_12635	COG1335	isochorismatase
AO498_12640	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
AO498_12690	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AO498_12695	COG1136	(ABC) transporter
AO498_12700	COG0045	succinate-CoA ligase (ADP-forming) activity
AO498_12715	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
AO498_12720	COG0187	DNA topoisomerase II activity
AO498_12760	COG0116	Belongs to the methyltransferase superfamily
AO498_12760	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
AO498_12765	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AO498_12790	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AO498_12800	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
AO498_12805	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AO498_12810	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AO498_12815	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
AO498_12815	COG0131	Imidazoleglycerol-phosphate dehydratase
AO498_12830	COG0463	Glycosyl transferase, family 2
AO498_12835	COG0577	efflux transmembrane transporter activity
AO498_12840	COG3876	Protein conserved in bacteria
AO498_12845	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AO498_12855	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
AO498_12860	COG0300	oxidoreductase activity
AO498_12865	COG1546	Belongs to the CinA family
AO498_12865	COG1058	Belongs to the CinA family
AO498_12870	COG0508	dehydrogenase complex catalyzes the overall conversion of
AO498_12875	COG0784	Response regulator, receiver
AO498_12875	COG2205	protein histidine kinase activity
AO498_12895	COG1703	isobutyryl-CoA mutase activity
AO498_12895	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AO498_12895	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AO498_12900	COG2814	Major facilitator Superfamily
AO498_12925	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AO498_12930	COG2072	flavoprotein involved in K transport
AO498_12940	COG1288	antiporter activity
AO498_12945	COG0667	Aldo Keto reductase
AO498_12960	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AO498_12970	COG2176	DNA-directed DNA polymerase activity
AO498_12975	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
AO498_12985	COG0628	permease
AO498_12990	COG3693	PFAM glycoside hydrolase, family 10
AO498_12990	COG2382	esterase
AO498_13000	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AO498_13005	COG0673	inositol 2-dehydrogenase activity
AO498_13010	COG4251	negative regulation of phosphorylation
AO498_13015	COG4251	negative regulation of phosphorylation
AO498_13030	COG1028	Short-chain dehydrogenase reductase Sdr
AO498_13045	COG1028	Short-chain dehydrogenase reductase Sdr
AO498_13050	COG0738	Major facilitator superfamily
AO498_13060	COG0657	acetylesterase activity
AO498_13060	COG2755	lipolytic protein G-D-S-L family
AO498_13080	COG0673	inositol 2-dehydrogenase activity
AO498_13100	COG0629	single-stranded DNA binding
AO498_13110	COG0277	FAD linked oxidase domain protein
AO498_13115	COG0004	ammonium transporteR
AO498_13125	COG0667	Aldo Keto reductase
AO498_13130	COG0205	6-phosphofructokinase activity
AO498_13140	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
AO498_13150	COG0784	Response regulator, receiver
AO498_13150	COG2205	protein histidine kinase activity
AO498_13160	COG0321	lipoyl(octanoyl) transferase activity
AO498_13160	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
AO498_13175	COG3279	Response regulator of the LytR AlgR family
AO498_13180	COG3275	phosphorelay sensor kinase activity
AO498_13185	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
AO498_13190	COG0469	pyruvate kinase activity
AO498_13200	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AO498_13205	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AO498_13210	COG0571	ribonuclease III activity
AO498_13220	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
AO498_13225	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
AO498_13250	COG0339	signal peptide processing
AO498_13255	COG0628	permease
AO498_13265	COG0784	Response regulator, receiver
AO498_13265	COG2205	protein histidine kinase activity
AO498_13285	COG2031	fatty acid transporter
AO498_13300	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
AO498_13310	COG0628	permease
AO498_13315	COG0012	GTP binding
AO498_13330	COG0488	(ABC) transporter
AO498_13350	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
AO498_13360	COG0429	hydrolase of the alpha beta-hydrolase fold
AO498_13365	COG2135	peptidase activity
AO498_13370	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AO498_13390	COG1940	carbohydrate kinase activity
AO498_13405	COG3119	arylsulfatase activity
AO498_13430	COG0346	lactoylglutathione lyase activity
AO498_13435	COG1506	peptidase
AO498_13435	COG0823	Involved in the tonB-independent uptake of proteins
AO498_13445	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
AO498_13450	COG0745	RESPONSE REGULATOR receiver
AO498_13455	COG5002	protein histidine kinase activity
AO498_13510	COG3530	Putative quorum-sensing-regulated virulence factor
AO498_13515	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
AO498_13520	COG0463	Glycosyl transferase, family 2
AO498_13530	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
AO498_13535	COG3206	protein involved in exopolysaccharide biosynthesis
AO498_13535	COG0489	protein tyrosine kinase activity
AO498_13585	COG0438	transferase activity, transferring glycosyl groups
AO498_13595	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AO498_13595	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AO498_13620	COG0463	Glycosyl transferase, family 2
AO498_13625	COG1216	Glycosyl transferase, family 2
AO498_13630	COG1442	glycosyl transferase family 8
AO498_13640	COG0463	Glycosyl transferase, family 2
AO498_13645	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AO498_13695	COG1696	Membrane protein involved in D-alanine export
AO498_13705	COG2852	Protein conserved in bacteria
AO498_13715	COG1216	Glycosyl transferase, family 2
AO498_13730	COG0463	Glycosyl transferase, family 2
AO498_13735	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
AO498_13745	COG0463	Glycosyl transferase, family 2
AO498_13770	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AO498_13780	COG0489	protein tyrosine kinase activity
AO498_13790	COG0529	Catalyzes the synthesis of activated sulfate
AO498_13795	COG2827	Endonuclease containing a URI domain
AO498_13835	COG1083	cytidylyl-transferase
AO498_13840	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
AO498_13845	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
AO498_13850	COG2089	acid synthase
AO498_13860	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
AO498_13870	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
AO498_13875	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
AO498_13885	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AO498_13890	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
AO498_13895	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
AO498_13895	COG0662	Cupin 2, conserved barrel domain protein
AO498_13905	COG1442	glycosyl transferase family 8
AO498_13940	COG0445	tRNA wobble uridine modification
AO498_13960	COG4206	TonB-dependent receptor
AO498_13960	COG1629	transport
AO498_13975	COG2089	acid synthase
AO498_13980	COG1083	cytidylyl-transferase
AO498_14005	COG0367	asparagine synthase
AO498_14050	COG0438	transferase activity, transferring glycosyl groups
AO498_14060	COG0367	asparagine synthase
AO498_14070	COG1132	(ABC) transporter
AO498_14090	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
AO498_14105	COG1215	transferase activity, transferring glycosyl groups
AO498_14150	COG2244	polysaccharide biosynthetic process
AO498_14200	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
AO498_14220	COG1522	sequence-specific DNA binding
AO498_14225	COG0719	Fe-S assembly protein
AO498_14230	COG0396	ATPase activity
AO498_14235	COG0719	Fe-S assembly protein
AO498_14240	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AO498_14245	COG2166	iron-sulfur cluster assembly
AO498_14250	COG2151	metal-sulfur cluster biosynthetic enzyme
AO498_14275	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AO498_14285	COG0408	coproporphyrinogen oxidase activity
AO498_14290	COG0671	phosphoesterase, PA-phosphatase related
AO498_14305	COG0477	Major facilitator Superfamily
AO498_14305	COG2814	Major facilitator Superfamily
AO498_14310	COG4251	negative regulation of phosphorylation
AO498_14315	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
AO498_14320	COG2706	6-phosphogluconolactonase activity
AO498_14330	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
AO498_14335	COG3279	Response regulator of the LytR AlgR family
AO498_14345	COG0166	Belongs to the GPI family
AO498_14355	COG1127	ABC transporter
AO498_14360	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AO498_14365	COG2205	protein histidine kinase activity
AO498_14365	COG2198	Histidine kinase
AO498_14365	COG0784	Response regulator, receiver
AO498_14365	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AO498_14385	COG1074	ATP-dependent DNA helicase activity
AO498_14390	COG3661	Belongs to the glycosyl hydrolase 67 family
AO498_14395	COG0277	FAD linked oxidase domain protein
AO498_14395	COG0247	lactate metabolic process
AO498_14400	COG1434	Gram-negative-bacterium-type cell wall biogenesis
AO498_14420	COG1028	Short-chain dehydrogenase reductase Sdr
AO498_14425	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AO498_14435	COG1119	ATPase activity
AO498_14450	COG1694	Mazg nucleotide pyrophosphohydrolase
AO498_14465	COG1028	Short-chain dehydrogenase reductase Sdr
AO498_14470	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
AO498_14470	COG0140	phosphoribosyl-ATP diphosphatase activity
AO498_14475	COG0107	imidazoleglycerol-phosphate synthase activity
AO498_14480	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
AO498_14485	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
AO498_14490	COG3186	Phenylalanine-4-hydroxylase
AO498_14495	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
AO498_14500	COG0159	tryptophan synthase activity
AO498_14505	COG0133	tryptophan synthase activity
AO498_14510	COG0135	phosphoribosylanthranilate isomerase activity
AO498_14515	COG0134	indole-3-glycerol-phosphate synthase activity
AO498_14520	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AO498_14525	COG0512	Glutamine amidotransferase of anthranilate synthase
AO498_14525	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AO498_14545	COG0587	DNA-directed DNA polymerase activity
AO498_14570	COG0456	acetyltransferase
AO498_14600	COG5505	Protein of unknown function (DUF819)
AO498_14615	COG0473	3-isopropylmalate dehydrogenase activity
AO498_14620	COG1024	Enoyl-CoA hydratase
AO498_14645	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AO498_14650	COG0154	amidase activity
AO498_14655	COG1388	LysM domain
AO498_14655	COG0741	lytic transglycosylase activity
AO498_14665	COG0281	malic enzyme
AO498_14665	COG0280	phosphate acetyltransferase
AO498_14670	COG0632	four-way junction helicase activity
AO498_14680	COG0509	glycine decarboxylation via glycine cleavage system
AO498_14700	COG1561	YicC-like family, N-terminal region
AO498_14710	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AO498_14715	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AO498_14720	COG1183	phosphatidylcholine synthase activity
AO498_14740	COG1216	Glycosyl transferase, family 2
AO498_14770	COG2072	flavoprotein involved in K transport
AO498_14800	COG1028	Short-chain dehydrogenase reductase Sdr
AO498_14810	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
AO498_14815	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
AO498_14815	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
AO498_14820	COG0799	negative regulation of ribosome biogenesis
AO498_14825	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AO498_14830	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AO498_14840	COG1047	Peptidyl-prolyl cis-trans
AO498_14845	COG2204	response regulator
AO498_14850	COG4191	Histidine kinase
AO498_14875	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AO498_14880	COG1506	peptidase
AO498_14880	COG0823	Involved in the tonB-independent uptake of proteins
AO498_14915	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AO498_14925	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
AO498_14930	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
AO498_14935	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
AO498_14945	COG0673	inositol 2-dehydrogenase activity
AO498_14980	COG0673	inositol 2-dehydrogenase activity
AO498_14985	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
AO498_14990	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
AO498_14995	COG4974	Belongs to the 'phage' integrase family
AO498_15020	COG0138	bifunctional purine biosynthesis protein purh
AO498_15025	COG0215	cysteine-tRNA ligase activity
AO498_15030	COG2234	aminopeptidase activity
AO498_15035	COG1609	Transcriptional regulator
AO498_15040	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
AO498_15080	COG4654	Cytochrome c, class I
AO498_15105	COG3119	arylsulfatase activity
AO498_15110	COG3386	PFAM SMP-30 Gluconolaconase
AO498_15115	COG4952	isomerase
AO498_15130	COG3347	Dehydrogenase
AO498_15130	COG1028	Short-chain dehydrogenase reductase Sdr
AO498_15135	COG2188	Transcriptional regulator
AO498_15145	COG0247	lactate metabolic process
AO498_15150	COG1139	Iron-sulfur cluster binding protein
AO498_15155	COG1556	Lactate utilization protein
AO498_15160	COG2205	protein histidine kinase activity
AO498_15200	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
AO498_15205	COG0300	oxidoreductase activity
AO498_15215	COG5000	phosphorelay sensor kinase activity
AO498_15225	COG2322	membrane
AO498_15240	COG1845	cytochrome c oxidase, subunit III
AO498_15245	COG1845	cytochrome c oxidase, subunit III
AO498_15250	COG0109	protoheme IX farnesyltransferase activity
AO498_15260	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AO498_15265	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AO498_15290	COG0437	4 iron, 4 sulfur cluster binding
AO498_15315	COG0539	negative regulation of cytoplasmic translation
AO498_15315	COG2183	response to ionizing radiation
AO498_15345	COG1131	(ABC) transporter
AO498_15355	COG0540	Belongs to the ATCase OTCase family
AO498_15360	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
AO498_15375	COG1796	DNA polymerase
AO498_15375	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
AO498_15455	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AO498_15465	COG1309	transcriptional regulator
AO498_15470	COG1525	nuclease
AO498_15490	COG0436	Aminotransferase
AO498_15540	COG0492	ferredoxin-NADP+ reductase activity
AO498_15565	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AO498_15565	COG1333	cytochrome c biogenesis protein
AO498_15630	COG0521	Mo-molybdopterin cofactor biosynthetic process
AO498_15630	COG0315	cyclic pyranopterin monophosphate synthase activity
AO498_15640	COG3119	arylsulfatase activity
AO498_15645	COG3119	arylsulfatase activity
AO498_15650	COG3119	arylsulfatase activity
AO498_15660	COG4771	TonB-dependent receptor
AO498_15685	COG1082	Xylose isomerase domain protein TIM barrel
AO498_15705	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AO498_15710	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AO498_15720	COG1028	Short-chain dehydrogenase reductase Sdr
AO498_15725	COG0574	Belongs to the PEP-utilizing enzyme family
AO498_15725	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AO498_15740	COG1272	protein, Hemolysin III
AO498_15750	COG2267	carboxylic ester hydrolase activity
AO498_15790	COG1629	transport
AO498_15790	COG4206	TonB-dependent receptor
AO498_15820	COG3655	Transcriptional regulator
AO498_15845	COG3384	dioxygenase
AO498_15855	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AO498_15875	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AO498_15915	COG2354	Protein conserved in bacteria
AO498_15925	COG0673	inositol 2-dehydrogenase activity
AO498_15930	COG0501	Belongs to the peptidase M48B family
AO498_15945	COG3022	response to hydroperoxide
AO498_16000	COG0017	Asparaginyl-tRNA synthetase
AO498_16010	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
AO498_16010	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
AO498_16015	COG2270	Major facilitator Superfamily
AO498_16035	COG0811	peptide transport
AO498_16045	COG0252	asparaginase activity
AO498_16050	COG0084	hydrolase, TatD family'
AO498_16055	COG1215	transferase activity, transferring glycosyl groups
AO498_16060	COG0726	polysaccharide deacetylase
AO498_16080	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
AO498_16105	COG3457	Alanine racemase
AO498_16120	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AO498_16125	COG1053	succinate dehydrogenase
AO498_16140	COG3011	Protein conserved in bacteria
AO498_16155	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
AO498_16165	COG0616	signal peptide processing
AO498_16170	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AO498_16185	COG2205	protein histidine kinase activity
AO498_16190	COG0745	RESPONSE REGULATOR receiver
AO498_16205	COG0126	phosphoglycerate kinase activity
AO498_16245	COG2333	competence protein COMEC
AO498_16245	COG0658	competence protein
AO498_16280	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AO498_16295	COG4181	ATPase activity
AO498_16310	COG1215	transferase activity, transferring glycosyl groups
AO498_16345	COG3437	response regulator, receiver
AO498_16350	COG0733	neurotransmitter:sodium symporter activity
AO498_16365	COG0181	hydroxymethylbilane synthase activity
AO498_16370	COG0189	ligase activity
AO498_16380	COG0470	DNA polymerase III
AO498_16390	COG0254	rRNA binding
AO498_16410	COG1012	belongs to the aldehyde dehydrogenase family
AO498_16420	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AO498_16425	COG1595	DNA-templated transcription, initiation
AO498_16445	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
AO498_16490	COG0101	tRNA pseudouridine synthase activity
AO498_16495	COG1132	(ABC) transporter
AO498_16515	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
AO498_16520	COG3217	Mosc domain protein beta barrel domain protein
AO498_16520	COG0633	Ferredoxin
AO498_16530	COG0443	Heat shock 70 kDa protein
AO498_16535	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
AO498_16550	COG0004	ammonium transporteR
AO498_16555	COG0113	porphobilinogen synthase activity
AO498_16565	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AO498_16570	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AO498_16575	COG0227	Belongs to the bacterial ribosomal protein bL28 family
AO498_16580	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AO498_16585	COG0552	protein localization to endoplasmic reticulum
AO498_16615	COG2226	methyltransferase
AO498_16620	COG0463	Glycosyl transferase, family 2
AO498_16620	COG1216	Glycosyl transferase, family 2
AO498_16640	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AO498_16675	COG1214	PFAM Peptidase M22, glycoprotease
AO498_16680	COG0793	Belongs to the peptidase S41A family
AO498_16685	COG0594	ribonuclease P activity
AO498_16687	COG0230	Belongs to the bacterial ribosomal protein bL34 family
AO498_16700	COG0612	Peptidase, M16
AO498_16705	COG0612	Peptidase, M16
AO498_16710	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AO498_16745	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AO498_16750	COG0022	dehydrogenase e1 component
AO498_16760	COG3119	arylsulfatase activity
AO498_16765	COG0101	tRNA pseudouridine synthase activity
AO498_16795	COG0473	3-isopropylmalate dehydrogenase activity
AO498_16800	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AO498_16805	COG0066	3-isopropylmalate dehydratase activity
AO498_16810	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AO498_16815	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AO498_16820	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
AO498_16830	COG0028	Belongs to the TPP enzyme family
AO498_16835	COG0129	dihydroxy-acid dehydratase activity
AO498_16840	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
AO498_16855	COG0343	queuine tRNA-ribosyltransferase activity
AO498_16860	COG0463	Glycosyl transferase, family 2
AO498_16860	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
AO498_16865	COG1595	DNA-templated transcription, initiation
AO498_16870	COG0357	Ribosomal RNA small subunit methyltransferase G
AO498_16895	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
AO498_16900	COG0709	Synthesizes selenophosphate from selenide and ATP