locus-tag	class	description
N3114_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
N3114_00010	COG0592	DNA-directed DNA polymerase activity
N3114_00015	COG0187	DNA topoisomerase II activity
N3114_00020	COG0492	ferredoxin-NADP+ reductase activity
N3114_00025	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
N3114_00035	COG1238	metal cluster binding
N3114_00040	COG0500	methyltransferase
N3114_00045	COG3842	ATPase activity
N3114_00085	COG0564	pseudouridine synthase activity
N3114_00090	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
N3114_00095	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
N3114_00100	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
N3114_00130	COG0604	alcohol dehydrogenase
N3114_00135	COG1733	regulation of RNA biosynthetic process
N3114_00140	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
N3114_00145	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
N3114_00160	COG1620	l-lactate permease
N3114_00165	COG0745	RESPONSE REGULATOR receiver
N3114_00170	COG3852	Histidine kinase
N3114_00175	COG1556	Lactate utilization protein
N3114_00180	COG1139	Iron-sulfur cluster binding protein
N3114_00185	COG0247	lactate metabolic process
N3114_00190	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
N3114_00195	COG0511	ligase activity, forming carbon-carbon bonds
N3114_00200	COG0439	Biotin carboxylase
N3114_00205	COG0513	Belongs to the DEAD box helicase family
N3114_00210	COG0306	phosphate transporter
N3114_00220	COG0367	asparagine synthase
N3114_00235	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
N3114_00240	COG1981	membrane
N3114_00245	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
N3114_00245	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
N3114_00250	COG1187	pseudouridine synthase activity
N3114_00255	COG0517	IMP dehydrogenase activity
N3114_00255	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
N3114_00260	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
N3114_00265	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
N3114_00270	COG0107	imidazoleglycerol-phosphate synthase activity
N3114_00285	COG0820	rRNA (adenine-C2-)-methyltransferase activity
N3114_00290	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
N3114_00295	COG0724	RNA recognition motif
N3114_00300	COG0745	RESPONSE REGULATOR receiver
N3114_00305	COG0642	Histidine kinase
N3114_00360	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
N3114_00365	COG0291	Belongs to the bacterial ribosomal protein bL35 family
N3114_00370	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
N3114_00385	COG0446	pyridine nucleotide-disulphide oxidoreductase
N3114_00390	COG0746	molybdenum cofactor guanylyltransferase activity
N3114_00395	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
N3114_00400	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
N3114_00405	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
N3114_00410	COG0268	Binds directly to 16S ribosomal RNA
N3114_00415	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
N3114_00425	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
N3114_00430	COG4943	cyclic-guanylate-specific phosphodiesterase activity
N3114_00435	COG0573	inorganic phosphate transmembrane transporter activity
N3114_00440	COG0581	inorganic phosphate transmembrane transporter activity
N3114_00445	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
N3114_00450	COG0704	Plays a role in the regulation of phosphate uptake
N3114_00460	COG0745	RESPONSE REGULATOR receiver
N3114_00465	COG5002	protein histidine kinase activity
N3114_00470	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
N3114_00475	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
N3114_00485	COG0546	phosphoglycolate phosphatase activity
N3114_00505	COG1484	DNA-dependent DNA replication
N3114_00520	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
N3114_00525	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
N3114_00540	COG1854	S-ribosylhomocysteine lyase activity
N3114_00555	COG1686	Belongs to the peptidase S11 family
N3114_00570	COG0646	methionine synthase
N3114_00570	COG1410	methionine synthase
N3114_00590	COG0140	phosphoribosyl-ATP diphosphatase activity
N3114_00590	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
N3114_00600	COG0489	protein tyrosine kinase activity
N3114_00605	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
N3114_00615	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
N3114_00615	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
N3114_00625	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
N3114_00630	COG0505	Belongs to the CarA family
N3114_00640	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
N3114_00645	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
N3114_00650	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
N3114_00655	COG2353	YceI-like domain
N3114_00660	COG1846	Transcriptional regulator
N3114_00685	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
N3114_00690	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
N3114_00695	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
N3114_00700	COG0237	dephospho-CoA kinase activity
N3114_00705	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
N3114_00710	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
N3114_00715	COG0456	acetyltransferase
N3114_00740	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
N3114_00745	COG0254	rRNA binding
N3114_00750	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
N3114_00765	COG0436	Aminotransferase
N3114_00770	COG0460	homoserine dehydrogenase
N3114_00780	COG0575	Belongs to the CDS family
N3114_00785	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
N3114_00800	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
N3114_00805	COG0023	Translation Initiation Factor
N3114_00810	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
N3114_00810	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
N3114_00815	COG1324	tolerance protein
N3114_00820	COG2022	thiamine diphosphate biosynthetic process
N3114_00895	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
N3114_00905	COG1346	cytolysis
N3114_00915	COG3766	membrane
N3114_00920	COG1301	dicarboxylic acid transport
N3114_00930	COG0204	Acyl-transferase
N3114_00930	COG0318	PFAM AMP-dependent synthetase and ligase
N3114_00935	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
N3114_00950	COG0666	response to abiotic stimulus
N3114_00960	COG0418	dihydroorotase activity
N3114_00970	COG1706	bacterial-type flagellum-dependent cell motility
N3114_01005	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
N3114_01030	COG0037	tRNA processing
N3114_01035	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
N3114_01040	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
N3114_01045	COG0601	transmembrane transport
N3114_01050	COG0736	holo-[acyl-carrier-protein] synthase activity
N3114_01055	COG0786	glutamate:sodium symporter activity
N3114_01060	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
N3114_01070	COG0560	Phosphoserine phosphatase
N3114_01080	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
N3114_01085	COG3248	Nucleoside-binding outer membrane protein
N3114_01090	COG1393	Belongs to the ArsC family
N3114_01095	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
N3114_01100	COG0343	queuine tRNA-ribosyltransferase activity
N3114_01110	COG0436	Aminotransferase
N3114_01130	COG2861	carbohydrate metabolic process
N3114_01135	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
N3114_01140	COG0557	exoribonuclease II activity
N3114_01145	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
N3114_01155	COG0360	Binds together with S18 to 16S ribosomal RNA
N3114_01160	COG0629	single-stranded DNA binding
N3114_01165	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
N3114_01175	COG0215	cysteine-tRNA ligase activity
N3114_01180	COG0195	Participates in both transcription termination and antitermination
N3114_01190	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
N3114_01195	COG2121	Domain of unknown function (DUF374)
N3114_01205	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
N3114_01215	COG0288	reversible hydration of carbon dioxide
N3114_01220	COG0156	8-amino-7-oxononanoate synthase activity
N3114_01225	COG0792	nuclease activity
N3114_01245	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
N3114_01255	COG0540	Belongs to the ATCase OTCase family
N3114_01260	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
N3114_01270	COG2824	Alkylphosphonate utilization operon protein PhnA
N3114_01275	COG1451	nucleotide metabolic process
N3114_01280	COG0730	response to heat
N3114_01305	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
N3114_01315	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
N3114_01320	COG0372	Belongs to the citrate synthase family
N3114_01325	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
N3114_01330	COG2828	Protein conserved in bacteria
N3114_01340	COG1335	isochorismatase
N3114_01345	COG0181	hydroxymethylbilane synthase activity
N3114_01355	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
N3114_01360	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
N3114_01365	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
N3114_01370	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
N3114_01375	COG0450	alkyl hydroperoxide reductase
N3114_01385	COG0105	UTP biosynthetic process
N3114_01395	COG0333	Belongs to the bacterial ribosomal protein bL32 family
N3114_01400	COG0416	fatty acid biosynthetic process
N3114_01405	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
N3114_01425	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
N3114_01430	COG1053	succinate dehydrogenase
N3114_01440	COG1007	ATP synthesis coupled electron transport
N3114_01450	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
N3114_01455	COG0713	ATP synthesis coupled electron transport
N3114_01460	COG0839	Belongs to the complex I subunit 6 family
N3114_01465	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
N3114_01470	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
N3114_01475	COG1034	ATP synthesis coupled electron transport
N3114_01480	COG0372	Belongs to the citrate synthase family
N3114_01495	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
N3114_01495	COG0649	NAD binding
N3114_01500	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
N3114_01505	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
N3114_01510	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
N3114_01515	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
N3114_01525	COG2966	Psort location CytoplasmicMembrane, score
N3114_01540	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
N3114_01565	COG4774	siderophore transport
N3114_01575	COG1971	Probably functions as a manganese efflux pump
N3114_01590	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
N3114_01595	COG1333	cytochrome c biogenesis protein
N3114_01595	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
N3114_01600	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
N3114_01605	COG3005	denitrification pathway
N3114_01615	COG2200	EAL domain
N3114_01615	COG3287	FIST C domain
N3114_01615	COG2199	diguanylate cyclase activity
N3114_01620	COG0840	transmembrane signaling receptor activity
N3114_01640	COG3043	anaerobic respiration
N3114_01645	COG0348	domain, Protein
N3114_01650	COG0437	4 iron, 4 sulfur cluster binding
N3114_01655	COG0243	molybdopterin cofactor binding
N3114_01665	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
N3114_01670	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
N3114_01680	COG2204	response regulator
N3114_01685	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
N3114_01690	COG1648	precorrin-2 dehydrogenase activity
N3114_01690	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
N3114_01705	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
N3114_01710	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
N3114_01715	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
N3114_01725	COG2404	hydrolase activity, acting on ester bonds
N3114_01730	COG1832	CoA-binding protein
N3114_01735	COG0642	Histidine kinase
N3114_01740	COG0745	RESPONSE REGULATOR receiver
N3114_01745	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
N3114_01750	COG0191	fructose-bisphosphate aldolase activity
N3114_01770	COG0811	peptide transport
N3114_01780	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
N3114_01785	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
N3114_01795	COG0142	geranyltranstransferase activity
N3114_01800	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
N3114_01805	COG0442	prolyl-tRNA aminoacylation
N3114_01810	COG0668	transmembrane transport
N3114_01830	COG0815	Transfers the fatty acyl group on membrane lipoproteins
N3114_01835	COG1862	Preprotein translocase
N3114_01840	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
N3114_01845	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
N3114_01860	COG1360	Flagellar Motor Protein
N3114_01865	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
N3114_01875	COG0495	leucyl-tRNA aminoacylation
N3114_01885	COG0285	dihydrofolate synthase activity
N3114_01945	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
N3114_01965	COG0745	RESPONSE REGULATOR receiver
N3114_01970	COG0642	Histidine kinase
N3114_01975	COG2081	HI0933 family
N3114_01980	COG0840	transmembrane signaling receptor activity
N3114_01995	COG5002	protein histidine kinase activity
N3114_02000	COG1692	metallophosphoesterase
N3114_02015	COG2226	methyltransferase
N3114_02020	COG1570	exodeoxyribonuclease VII activity
N3114_02025	COG0835	chemotaxis
N3114_02030	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
N3114_02035	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
N3114_02040	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
N3114_02050	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
N3114_02055	COG0459	protein refolding
N3114_02060	COG5002	protein histidine kinase activity
N3114_02065	COG0745	RESPONSE REGULATOR receiver
N3114_02070	COG1408	metallophosphoesterase
N3114_02095	COG1136	(ABC) transporter
N3114_02115	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
N3114_02120	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
N3114_02125	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
N3114_02135	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
N3114_02145	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
N3114_02150	COG2264	protein methyltransferase activity
N3114_02155	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
N3114_02180	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
N3114_02195	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
N3114_02245	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
N3114_02250	COG1090	epimerase
N3114_02255	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
N3114_02270	COG0481	GTPase activity
N3114_02275	COG1937	Protein conserved in bacteria
N3114_02285	COG2608	mercury ion transmembrane transporter activity
N3114_02295	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
N3114_02305	COG0482	sulfurtransferase activity
N3114_02310	COG0482	sulfurtransferase activity
N3114_02315	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
N3114_02320	COG0006	proline dipeptidase activity
N3114_02325	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
N3114_02330	COG0402	S-adenosylhomocysteine deaminase activity
N3114_02335	COG0616	signal peptide processing
N3114_02345	COG0280	phosphate acetyltransferase
N3114_02350	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
N3114_02360	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
N3114_02365	COG2176	DNA-directed DNA polymerase activity
N3114_02395	COG2176	DNA-directed DNA polymerase activity
N3114_02405	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
N3114_02420	COG5002	protein histidine kinase activity
N3114_02465	COG1546	Belongs to the CinA family
N3114_02465	COG1058	Belongs to the CinA family
N3114_02470	COG0579	oxidoreductase
N3114_02475	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
N3114_02490	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
N3114_02505	COG0667	Aldo Keto reductase
N3114_02510	COG0306	phosphate transporter
N3114_02515	COG0840	transmembrane signaling receptor activity
N3114_02525	COG0840	transmembrane signaling receptor activity
N3114_02530	COG0824	Thioesterase
N3114_02540	COG0501	Belongs to the peptidase M48B family
N3114_02545	COG1322	Protein conserved in bacteria
N3114_02565	COG0037	tRNA processing
N3114_02585	COG0052	Belongs to the universal ribosomal protein uS2 family
N3114_02590	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
N3114_02595	COG1136	(ABC) transporter
N3114_02605	COG0194	GDP metabolic process
N3114_02610	COG5001	Diguanylate cyclase
N3114_02610	COG5002	protein histidine kinase activity
N3114_02615	COG2217	Heavy metal translocating P-type atpase
N3114_02630	COG4608	Belongs to the ABC transporter superfamily
N3114_02635	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
N3114_02640	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
N3114_02650	COG1434	Gram-negative-bacterium-type cell wall biogenesis
N3114_02655	COG1121	(ABC) transporter
N3114_02660	COG1108	ABC-type Mn2 Zn2 transport systems permease components
N3114_02665	COG2996	Protein conserved in bacteria
N3114_02670	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
N3114_02690	COG0210	DNA helicase
N3114_02695	COG0475	glutathione-regulated potassium exporter activity
N3114_02695	COG0569	domain protein
N3114_02700	COG0525	valine-tRNA ligase activity
N3114_02705	COG4895	conserved protein (DUF2196)
N3114_02725	COG2814	Major facilitator Superfamily
N3114_02730	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
N3114_02750	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
N3114_02755	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
N3114_02760	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
N3114_02770	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
N3114_02775	COG1846	Transcriptional regulator
N3114_02805	COG0439	Biotin carboxylase
N3114_02810	COG2151	metal-sulfur cluster biosynthetic enzyme
N3114_02815	COG2166	iron-sulfur cluster assembly
N3114_02820	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
N3114_02830	COG0396	ATPase activity
N3114_02835	COG0719	Fe-S assembly protein
N3114_02845	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
N3114_02845	COG0822	iron-sulfur transferase activity
N3114_02845	COG2906	2 iron, 2 sulfur cluster binding
N3114_02855	COG3706	GGDEF domain
N3114_02860	COG0165	Argininosuccinate lyase
N3114_02865	COG0835	chemotaxis
N3114_02865	COG0784	Response regulator, receiver
N3114_02870	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
N3114_02875	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
N3114_02885	COG0556	nucleotide-excision repair
N3114_02895	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
N3114_02915	COG0840	transmembrane signaling receptor activity
N3114_02925	COG1484	DNA-dependent DNA replication
N3114_02930	COG4584	PFAM Integrase catalytic
N3114_02950	COG0698	ribose 5-phosphate isomerase
N3114_02955	COG0681	Belongs to the peptidase S26 family
N3114_02960	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
N3114_02965	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
N3114_02970	COG0193	aminoacyl-tRNA hydrolase activity
N3114_02985	COG0860	N-Acetylmuramoyl-L-alanine amidase
N3114_02995	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
N3114_03000	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
N3114_03010	COG0528	UMP kinase activity
N3114_03020	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
N3114_03025	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
N3114_03030	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
N3114_03040	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
N3114_03045	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
N3114_03055	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
N3114_03065	COG0305	Participates in initiation and elongation during chromosome replication
N3114_03075	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
N3114_03150	COG0367	asparagine synthase
N3114_03170	COG1063	alcohol dehydrogenase
N3114_03190	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
N3114_03195	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
N3114_03200	COG1086	Polysaccharide biosynthesis protein
N3114_03210	COG1793	dna ligase
N3114_03215	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
N3114_03220	COG0133	tryptophan synthase activity
N3114_03230	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
N3114_03240	COG0848	biopolymer transport protein
N3114_03260	COG0577	efflux transmembrane transporter activity
N3114_03260	COG1136	(ABC) transporter
N3114_03265	COG0577	efflux transmembrane transporter activity
N3114_03265	COG1136	(ABC) transporter
N3114_03310	COG0735	belongs to the Fur family
N3114_03320	COG0114	fumarate hydratase activity
N3114_03330	COG3920	Histidine kinase
N3114_03335	COG0784	Response regulator, receiver
N3114_03340	COG4774	siderophore transport
N3114_03345	COG3128	pkhd-type hydroxylase
N3114_03355	COG4771	TonB-dependent receptor
N3114_03375	COG1966	Carbon starvation protein
N3114_03475	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
N3114_03495	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
N3114_03520	COG1484	DNA-dependent DNA replication
N3114_03590	COG2226	methyltransferase
N3114_03600	COG0456	acetyltransferase
N3114_03625	COG1484	DNA-dependent DNA replication
N3114_03715	COG0012	GTP binding
N3114_03735	COG3123	guanosine phosphorylase activity
N3114_03745	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
N3114_03750	COG0585	pseudouridine synthase activity
N3114_03760	COG0840	transmembrane signaling receptor activity
N3114_03765	COG0632	four-way junction helicase activity
N3114_03770	COG1181	Belongs to the D-alanine--D-alanine ligase family
N3114_03795	COG0051	transcription antitermination factor activity, RNA binding
N3114_03800	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
N3114_03805	COG0088	Forms part of the polypeptide exit tunnel
N3114_03810	COG0089	rRNA binding
N3114_03815	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
N3114_03820	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
N3114_03825	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
N3114_03830	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
N3114_03835	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
N3114_03840	COG0255	Belongs to the universal ribosomal protein uL29 family
N3114_03845	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
N3114_03850	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
N3114_03855	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
N3114_03860	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
N3114_03865	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
N3114_03870	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
N3114_03875	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
N3114_03880	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
N3114_03885	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
N3114_03890	COG0200	Binds to the 23S rRNA
N3114_03895	COG0201	protein transport
N3114_03900	COG0024	Methionine aminopeptidase
N3114_03905	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
N3114_03910	COG1573	uracil-dna glycosylase
N3114_03920	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
N3114_03930	COG1032	radical SAM domain protein
N3114_03940	COG0563	adenylate kinase activity
N3114_03950	COG1064	alcohol dehydrogenase
N3114_03955	COG1979	alcohol dehydrogenase
N3114_03960	COG0840	transmembrane signaling receptor activity
N3114_03965	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
N3114_03970	COG0322	excinuclease ABC activity
N3114_03975	COG0840	transmembrane signaling receptor activity
N3114_03980	COG0745	RESPONSE REGULATOR receiver
N3114_03990	COG0784	Response regulator, receiver
N3114_03990	COG2205	protein histidine kinase activity
N3114_04045	COG0829	nickel cation binding
N3114_04050	COG0832	Belongs to the urease beta subunit family
N3114_04050	COG0831	urea catabolic process
N3114_04055	COG0804	urea catabolic process
N3114_04060	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
N3114_04070	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
N3114_04110	COG0708	Exodeoxyribonuclease III
N3114_04130	COG3040	lipid binding
N3114_04145	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
N3114_04155	COG2200	EAL domain
N3114_04160	COG3279	Response regulator of the LytR AlgR family
N3114_04165	COG3275	phosphorelay sensor kinase activity
N3114_04170	COG1233	COG1233 Phytoene dehydrogenase and related
N3114_04175	COG0415	Belongs to the DNA photolyase family
N3114_04195	COG0166	Belongs to the GPI family
N3114_04240	COG0840	transmembrane signaling receptor activity
N3114_04245	COG1942	4-Oxalocrotonate Tautomerase
N3114_04250	COG0583	DNA-binding transcription factor activity
N3114_04255	COG0134	indole-3-glycerol-phosphate synthase activity
N3114_04265	COG0727	PFAM Uncharacterised protein family (UPF0153)
N3114_04270	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
N3114_04280	COG0674	pyruvate-flavodoxin oxidoreductase activity
N3114_04280	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
N3114_04285	COG1013	pyruvate-flavodoxin oxidoreductase activity
N3114_04295	COG2176	DNA-directed DNA polymerase activity
N3114_04300	COG0135	phosphoribosylanthranilate isomerase activity
N3114_04305	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
N3114_04325	COG1666	GTP binding
N3114_04335	COG2363	Small membrane protein
N3114_04340	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
N3114_04355	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
N3114_04360	COG0750	zinc metalloprotease
N3114_04365	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
N3114_04370	COG1028	Short-chain dehydrogenase reductase Sdr
N3114_04375	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
N3114_04385	COG0167	dihydroorotate dehydrogenase activity
N3114_04390	COG1132	(ABC) transporter
N3114_04395	COG0728	peptidoglycan biosynthetic process
N3114_04410	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
N3114_04420	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
N3114_04425	COG3150	esterase
N3114_04435	COG0552	protein localization to endoplasmic reticulum
N3114_04440	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
N3114_04445	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
N3114_04450	COG1418	mRNA catabolic process
N3114_04455	COG0742	ribosomal rna small subunit methyltransferase
N3114_04460	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
N3114_04480	COG0300	oxidoreductase activity
N3114_04495	COG3258	Cytochrome c
N3114_04505	COG0745	RESPONSE REGULATOR receiver
N3114_04510	COG0642	Histidine kinase
N3114_04515	COG0157	Belongs to the NadC ModD family
N3114_04525	COG1610	YqeY-like protein
N3114_04530	COG0488	(ABC) transporter
N3114_04540	COG0492	ferredoxin-NADP+ reductase activity
N3114_04545	COG0596	Alpha beta hydrolase
N3114_04585	COG0518	GMP synthase (glutamine-hydrolyzing) activity
N3114_04585	COG0519	Catalyzes the synthesis of GMP from XMP
N3114_04590	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
N3114_04600	COG1451	nucleotide metabolic process
N3114_04605	COG0436	Aminotransferase
N3114_04610	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
N3114_04630	COG1484	DNA-dependent DNA replication
N3114_04660	COG1696	Membrane protein involved in D-alanine export
N3114_04670	COG2223	nitrite transmembrane transporter activity
N3114_04680	COG0310	cobalt ion transport
N3114_04725	COG0628	permease
N3114_04750	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
N3114_04760	COG0840	transmembrane signaling receptor activity
N3114_04770	COG0730	response to heat
N3114_04775	COG1045	serine acetyltransferase
N3114_04780	COG1166	arginine decarboxylase activity
N3114_04785	COG0124	histidyl-tRNA synthetase
N3114_04790	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
N3114_04795	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
N3114_04800	COG0163	prenyltransferase activity
N3114_04810	COG0359	binds to the 23S rRNA
N3114_04815	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
N3114_04820	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
N3114_04830	COG0084	hydrolase, TatD family'
N3114_04840	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
N3114_04845	COG0131	Imidazoleglycerol-phosphate dehydratase
N3114_04850	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
N3114_04865	COG0218	Necessary for normal cell division and for the maintenance of normal septation
N3114_04870	COG0456	acetyltransferase
N3114_04875	COG1595	DNA-templated transcription, initiation
N3114_04890	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
N3114_04895	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
N3114_04920	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
N3114_04930	COG0784	Response regulator, receiver
N3114_04930	COG3437	response regulator, receiver
N3114_04940	COG0768	penicillin binding
N3114_04960	COG2884	Cell division ATP-binding protein ftsE
N3114_04965	COG0220	tRNA (guanine-N7-)-methyltransferase activity
N3114_04975	COG0564	pseudouridine synthase activity
N3114_04980	COG0772	Belongs to the SEDS family
N3114_04990	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
N3114_04995	COG3123	guanosine phosphorylase activity
N3114_05015	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
N3114_05020	COG0066	3-isopropylmalate dehydratase activity
N3114_05025	COG0473	3-isopropylmalate dehydrogenase activity
N3114_05040	COG0257	Belongs to the bacterial ribosomal protein bL36 family
N3114_05045	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
N3114_05050	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
N3114_05055	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
N3114_05060	COG0202	RNA polymerase activity
N3114_05065	COG0203	ribosomal protein L17
N3114_05070	COG0154	amidase activity
N3114_05075	COG0517	IMP dehydrogenase activity
N3114_05075	COG0516	GMP reductase activity
N3114_05090	COG0484	heat shock protein binding
N3114_05100	COG1472	Belongs to the glycosyl hydrolase 3 family
N3114_05105	COG1119	ATPase activity
N3114_05130	COG1733	regulation of RNA biosynthetic process
N3114_05135	COG2249	NAD(P)H dehydrogenase (quinone) activity
N3114_05145	COG2076	Multidrug Resistance protein
N3114_05170	COG1881	PFAM PEBP family protein
N3114_05175	COG0583	DNA-binding transcription factor activity
N3114_05180	COG2855	membrane
N3114_05210	COG1733	regulation of RNA biosynthetic process
N3114_05215	COG2249	NAD(P)H dehydrogenase (quinone) activity
N3114_05235	COG0778	Nitroreductase
N3114_05245	COG0488	(ABC) transporter
N3114_05250	COG1607	acyl-coa hydrolase
N3114_05260	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
N3114_05265	COG0754	glutathionylspermidine amidase activity
N3114_05360	COG3344	reverse transcriptase
N3114_05390	COG0358	DNA primase activity
N3114_05485	COG3287	FIST C domain
N3114_05485	COG2200	EAL domain
N3114_05485	COG2199	diguanylate cyclase activity
N3114_05495	COG1525	nuclease
N3114_05570	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
N3114_05585	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
N3114_05595	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
N3114_05605	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
N3114_05610	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
N3114_05620	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
N3114_05630	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
N3114_05850	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
N3114_05855	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
N3114_05860	COG1496	oxidoreductase activity
N3114_05865	COG0280	phosphate acetyltransferase
N3114_05865	COG0281	malic enzyme
N3114_05870	COG0788	formyltetrahydrofolate deformylase activity
N3114_05875	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
N3114_05900	COG0745	RESPONSE REGULATOR receiver
N3114_05910	COG0330	HflC and HflK could
N3114_05935	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
N3114_05940	COG1187	pseudouridine synthase activity
N3114_05945	COG0546	phosphoglycolate phosphatase activity
N3114_05965	COG4206	TonB-dependent receptor
N3114_05975	COG1122	ATPase activity
N3114_05990	COG1132	(ABC) transporter
N3114_06000	COG0745	RESPONSE REGULATOR receiver
N3114_06005	COG0642	Histidine kinase
N3114_06030	COG0513	Belongs to the DEAD box helicase family
N3114_06040	COG0745	RESPONSE REGULATOR receiver
N3114_06075	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
N3114_06085	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
N3114_06090	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
N3114_06100	COG0521	Mo-molybdopterin cofactor biosynthetic process
N3114_06105	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
N3114_06110	COG0454	-acetyltransferase
N3114_06150	COG0243	molybdopterin cofactor binding
N3114_06160	COG1193	negative regulation of DNA recombination
N3114_06165	COG1253	flavin adenine dinucleotide binding
N3114_06175	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
N3114_06180	COG0004	ammonium transporteR
N3114_06195	COG0248	Ppx GppA phosphatase
N3114_06205	COG0028	Belongs to the TPP enzyme family
N3114_06210	COG0440	acetolactate synthase activity
N3114_06215	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
N3114_06220	COG1196	nuclear chromosome segregation
N3114_06220	COG1674	ftsk spoiiie
N3114_06225	COG0745	RESPONSE REGULATOR receiver
N3114_06230	COG0642	Histidine kinase
N3114_06245	COG0653	protein targeting
N3114_06255	COG1160	GTP binding
N3114_06260	COG0659	secondary active sulfate transmembrane transporter activity
N3114_06280	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
N3114_06290	COG1185	polyribonucleotide nucleotidyltransferase activity
N3114_06300	COG2198	Histidine kinase
N3114_06300	COG0643	Histidine kinase
N3114_06305	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
N3114_06310	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
N3114_06315	COG2201	protein-glutamate methylesterase activity
N3114_06325	COG2223	nitrite transmembrane transporter activity
N3114_06330	COG0582	viral genome integration into host DNA
N3114_06350	COG0339	signal peptide processing
N3114_06355	COG2890	protein-(glutamine-N5) methyltransferase activity
N3114_06360	COG0635	Involved in the biosynthesis of porphyrin-containing compound
N3114_06365	COG0494	nUDIX hydrolase
N3114_06370	COG0527	aspartate kinase activity
N3114_06385	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
N3114_06390	COG0287	Prephenate dehydrogenase
N3114_06395	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
N3114_06400	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
N3114_06405	COG0612	Peptidase, M16
N3114_06410	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
N3114_06435	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
N3114_06445	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
N3114_06445	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
N3114_06470	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
N3114_06495	COG0751	glycine-tRNA ligase activity
N3114_06515	COG0357	Ribosomal RNA small subunit methyltransferase G
N3114_06520	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
N3114_06525	COG0113	porphobilinogen synthase activity
N3114_06555	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
N3114_06555	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
N3114_06560	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
N3114_06565	COG0635	Involved in the biosynthesis of porphyrin-containing compound
N3114_06575	COG1663	tetraacyldisaccharide 4'-kinase activity
N3114_06585	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
N3114_06605	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
N3114_06610	COG0805	protein transport
N3114_06615	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
N3114_06620	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
N3114_06630	COG4206	TonB-dependent receptor
N3114_06665	COG0247	lactate metabolic process
N3114_06665	COG2181	nitrate reductase activity
N3114_06670	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
N3114_06690	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
N3114_06695	COG3287	FIST C domain
N3114_06695	COG2199	diguanylate cyclase activity
N3114_06695	COG2200	EAL domain
N3114_06700	COG1137	ATPase activity
N3114_06705	COG0802	atpase or kinase
N3114_06710	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
N3114_06725	COG0137	argininosuccinate synthase activity
N3114_06730	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
N3114_06735	COG1696	Membrane protein involved in D-alanine export
N3114_06750	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
N3114_06760	COG0569	domain protein
N3114_06765	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
N3114_06770	COG0745	RESPONSE REGULATOR receiver
N3114_06775	COG2205	protein histidine kinase activity
N3114_06790	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
N3114_06795	COG0484	heat shock protein binding
N3114_06800	COG0133	tryptophan synthase activity
N3114_06820	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
N3114_06830	COG2199	diguanylate cyclase activity
N3114_06835	COG0500	methyltransferase
N3114_06845	COG1333	cytochrome c biogenesis protein
N3114_06845	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
N3114_06850	COG2195	Cleaves the N-terminal amino acid of tripeptides
N3114_06860	COG0840	transmembrane signaling receptor activity
N3114_06875	COG0653	protein targeting
N3114_06880	COG4591	ABC-type transport system involved in lipoprotein release permease component
N3114_06890	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
N3114_06900	COG0039	L-malate dehydrogenase activity
N3114_06915	COG1484	DNA-dependent DNA replication
N3114_06935	COG0275	rRNA processing
N3114_06945	COG0776	regulation of translation
N3114_06955	COG1959	2 iron, 2 sulfur cluster binding
N3114_06980	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
N3114_06980	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
N3114_06990	COG2201	protein-glutamate methylesterase activity
N3114_07005	COG0484	heat shock protein binding
N3114_07010	COG0789	Transcriptional regulator
N3114_07020	COG1131	(ABC) transporter
N3114_07025	COG0842	Transport permease protein
N3114_07030	COG0842	Transport permease protein
N3114_07035	COG0861	Integral membrane protein TerC family
N3114_07040	COG1114	Component of the transport system for branched-chain amino acids
N3114_07060	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
N3114_07070	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
N3114_07080	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
N3114_07085	COG4773	Receptor
N3114_07095	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
N3114_07135	COG0488	(ABC) transporter
N3114_07145	COG2171	N-acyltransferase activity
N3114_07155	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
N3114_07185	COG0309	Hydrogenase expression formation protein (HypE)
N3114_07195	COG2084	Dehydrogenase
N3114_07200	COG0409	Hydrogenase expression formation protein
N3114_07205	COG0298	carbon dioxide binding
N3114_07210	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
N3114_07220	COG0840	transmembrane signaling receptor activity
N3114_07235	COG2081	HI0933 family
N3114_07240	COG2354	Protein conserved in bacteria
N3114_07250	COG2814	Major facilitator Superfamily
N3114_07260	COG0301	tRNA thio-modification
N3114_07260	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
N3114_07280	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
N3114_07285	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
N3114_07290	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
N3114_07295	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
N3114_07300	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
N3114_07305	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
N3114_07325	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
N3114_07340	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
N3114_07345	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
N3114_07360	COG1309	transcriptional regulator
N3114_07365	COG1049	propionate catabolic process, 2-methylcitrate cycle
N3114_07375	COG2203	Gaf domain
N3114_07375	COG3706	GGDEF domain
N3114_07375	COG4251	negative regulation of phosphorylation
N3114_07375	COG5001	Diguanylate cyclase
N3114_07380	COG0217	transcriptional regulatory protein
N3114_07385	COG2853	Lipoprotein
N3114_07400	COG1611	Belongs to the LOG family
N3114_07405	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
N3114_07420	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
N3114_07440	COG4773	Receptor
N3114_07455	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
N3114_07470	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
N3114_07500	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
N3114_07505	COG2258	MOSC domain
N3114_07510	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
N3114_07515	COG0095	Lipoate-protein ligase
N3114_07520	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
N3114_07525	COG0508	dehydrogenase complex catalyzes the overall conversion of
N3114_07530	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
N3114_07535	COG1492	cobalamin metabolic process
N3114_07550	COG0513	Belongs to the DEAD box helicase family
N3114_07555	COG1944	ATP diphosphatase activity
N3114_07570	COG0840	transmembrane signaling receptor activity
N3114_07575	COG0328	RNA-DNA hybrid ribonuclease activity
N3114_07580	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
N3114_07605	COG1104	cysteine desulfurase activity
N3114_07610	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
N3114_07620	COG0437	4 iron, 4 sulfur cluster binding
N3114_07675	COG1305	Transglutaminase-like
N3114_07685	COG0437	4 iron, 4 sulfur cluster binding
N3114_07700	COG0709	Synthesizes selenophosphate from selenide and ATP
N3114_07715	COG0739	heme binding
N3114_07715	COG1196	nuclear chromosome segregation
N3114_07715	COG0741	lytic transglycosylase activity
N3114_07800	COG0740	serine-type endopeptidase activity
N3114_07815	COG1802	Transcriptional regulator
N3114_07815	COG4626	Terminase
N3114_07910	COG0489	protein tyrosine kinase activity
N3114_07920	COG1475	DNA binding
N3114_07960	COG1921	L-seryl-tRNASec selenium transferase activity
N3114_08025	COG1078	dGTPase activity
N3114_08030	COG2200	EAL domain
N3114_08030	COG2199	diguanylate cyclase activity
N3114_08030	COG3287	FIST C domain
N3114_08035	COG0259	pyridoxamine-phosphate oxidase activity
N3114_08045	COG0513	Belongs to the DEAD box helicase family
N3114_08065	COG0326	Molecular chaperone. Has ATPase activity
N3114_08070	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
N3114_08090	COG2995	paraquat-inducible protein a
N3114_08105	COG5002	protein histidine kinase activity
N3114_08105	COG5001	Diguanylate cyclase
N3114_08135	COG1484	DNA-dependent DNA replication
N3114_08150	COG4335	DNA alkylation repair
N3114_08160	COG3706	GGDEF domain
N3114_08175	COG0010	Belongs to the arginase family
N3114_08180	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
N3114_08195	COG0326	Molecular chaperone. Has ATPase activity
N3114_08200	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
N3114_08205	COG0668	transmembrane transport
N3114_08210	COG1227	inorganic diphosphatase activity
N3114_08225	COG1027	Aspartate ammonia-lyase
N3114_08230	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
N3114_08235	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
N3114_08240	COG1047	Peptidyl-prolyl cis-trans
N3114_08255	COG0823	Involved in the tonB-independent uptake of proteins
N3114_08265	COG0848	biopolymer transport protein
N3114_08270	COG0811	peptide transport
N3114_08275	COG0355	proton-transporting ATP synthase activity, rotational mechanism
N3114_08280	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
N3114_08285	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
N3114_08290	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
N3114_08295	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
N3114_08300	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
N3114_08310	COG1475	DNA binding
N3114_08315	COG1192	Involved in chromosome partitioning
N3114_08330	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
N3114_08335	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
N3114_08340	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
N3114_08345	COG0211	Belongs to the bacterial ribosomal protein bL27 family
N3114_08350	COG0261	This protein binds to 23S rRNA in the presence of protein L20
N3114_08355	COG0358	DNA primase activity
N3114_08365	COG0571	ribonuclease III activity
N3114_08370	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
N3114_08380	COG0501	Belongs to the peptidase M48B family
N3114_08400	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
N3114_08410	COG0706	membrane insertase activity
N3114_08415	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
N3114_08420	COG0594	ribonuclease P activity
N3114_08425	COG0230	Belongs to the bacterial ribosomal protein bL34 family
N3114_08430	COG0542	response to heat
N3114_08435	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
N3114_08445	COG2326	polyphosphate kinase activity
N3114_08455	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
N3114_08460	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
N3114_08465	COG0179	Fumarylacetoacetate (FAA) hydrolase
N3114_08490	COG0138	bifunctional purine biosynthesis protein purh
N3114_08495	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
N3114_08505	COG0739	heme binding
N3114_08510	COG0302	gtp cyclohydrolase
N3114_08515	COG0598	Magnesium transport protein CorA
N3114_08540	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
N3114_08545	COG0606	chelatase, subunit chli
N3114_08550	COG0840	transmembrane signaling receptor activity
N3114_08565	COG0242	peptide deformylase activity
N3114_08570	COG0740	serine-type endopeptidase activity
N3114_08575	COG0544	peptidyl-prolyl cis-trans isomerase activity
N3114_08620	COG0626	cystathionine gamma-synthase activity
N3114_08635	COG0840	transmembrane signaling receptor activity
N3114_08640	COG4191	Histidine kinase
N3114_08675	COG0745	RESPONSE REGULATOR receiver
N3114_08685	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
N3114_08700	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
N3114_08705	COG1858	cytochrome C peroxidase
N3114_08735	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
N3114_08755	COG1484	DNA-dependent DNA replication
N3114_08795	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
N3114_08815	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
N3114_08820	COG1061	Type III restriction enzyme res subunit
N3114_08845	COG1002	Type II restriction enzyme, methylase subunits
N3114_08950	COG0351	phosphomethylpyrimidine kinase
N3114_08955	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
N3114_08970	COG0348	domain, Protein
N3114_08990	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
N3114_08995	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
N3114_09015	COG0716	FMN binding
N3114_09030	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
N3114_09035	COG0159	tryptophan synthase activity
N3114_09040	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
N3114_09045	COG2255	four-way junction helicase activity
N3114_09050	COG0628	permease
N3114_09090	COG0731	radical SAM domain protein
N3114_09095	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
N3114_09105	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
N3114_09120	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
N3114_09130	COG0227	Belongs to the bacterial ribosomal protein bL28 family
N3114_09140	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
N3114_09150	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
N3114_09150	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
N3114_09155	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
N3114_09165	COG1484	DNA-dependent DNA replication
N3114_09170	COG4584	PFAM Integrase catalytic
N3114_09185	COG1696	Membrane protein involved in D-alanine export
N3114_09190	COG0859	PFAM glycosyl transferase family 9
N3114_09200	COG0859	PFAM glycosyl transferase family 9
N3114_09205	COG0463	Glycosyl transferase, family 2
N3114_09220	COG0438	transferase activity, transferring glycosyl groups
N3114_09225	COG0463	Glycosyl transferase, family 2
N3114_09225	COG1216	Glycosyl transferase, family 2
N3114_09255	COG1088	dTDP-glucose 4,6-dehydratase activity
N3114_09290	COG0859	PFAM glycosyl transferase family 9
N3114_09300	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
N3114_09310	COG0493	'glutamate synthase
N3114_09315	COG0069	glutamate synthase activity
N3114_09315	COG0070	glutamate synthase
N3114_09315	COG0067	glutamate synthase
N3114_09330	COG0840	transmembrane signaling receptor activity
N3114_09345	COG1739	Uncharacterized protein family UPF0029
N3114_09355	COG0196	riboflavin kinase activity
N3114_09360	COG2226	methyltransferase
N3114_09365	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
N3114_09375	COG0277	FAD linked oxidase domain protein
N3114_09380	COG1295	ribonuclease BN
N3114_09390	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
N3114_09400	COG2877	3-deoxy-8-phosphooctulonate synthase activity
N3114_09405	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
N3114_09410	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
N3114_09415	COG0284	orotidine-5'-phosphate decarboxylase activity
N3114_09445	COG1918	ferrous iron import across plasma membrane
N3114_09450	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
N3114_09450	COG1918	ferrous iron import across plasma membrane
N3114_09475	COG2217	Heavy metal translocating P-type atpase
N3114_09485	COG4773	Receptor
N3114_09495	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
N3114_09510	COG1278	Cold shock
N3114_09520	COG2207	Transcriptional regulator
N3114_09520	COG4753	response regulator
N3114_09525	COG3852	Histidine kinase
N3114_09560	COG0450	alkyl hydroperoxide reductase
N3114_09565	COG3118	belongs to the thioredoxin family
N3114_09580	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
N3114_09585	COG0085	RNA polymerase activity
N3114_09590	COG0222	ribosome binding
N3114_09595	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
N3114_09600	COG0081	regulation of translation
N3114_09605	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
N3114_09610	COG0250	Participates in transcription elongation, termination and antitermination
N3114_09625	COG0267	Belongs to the bacterial ribosomal protein bL33 family
N3114_09630	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
N3114_09660	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
N3114_09665	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
N3114_09670	COG0444	Belongs to the ABC transporter superfamily
N3114_09675	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
N3114_09680	COG0174	glutamine synthetase
N3114_09690	COG0314	molybdopterin synthase activity
N3114_09700	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
N3114_09705	COG1968	undecaprenyl-diphosphatase activity
N3114_09710	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
N3114_09715	COG0772	Belongs to the SEDS family
N3114_09725	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
N3114_09765	COG0542	response to heat
N3114_09770	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
N3114_09775	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
N3114_09790	COG2030	dehydratase
N3114_09810	COG0840	transmembrane signaling receptor activity
N3114_09815	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
N3114_09835	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
N3114_09840	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
N3114_09850	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
N3114_09855	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
N3114_09860	COG1157	protein secretion by the type III secretion system
N3114_09870	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
N3114_09890	COG1677	Flagellar hook-basal body complex protein FliE
N3114_09900	COG0455	bacterial-type flagellum organization
N3114_09905	COG1419	protein localization to endoplasmic reticulum
N3114_09920	COG3951	Flagellar rod assembly protein muramidase FlgJ
N3114_09925	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
N3114_09945	COG1749	Flagellar hook protein flgE
N3114_09950	COG4786	Flagellar basal body rod
N3114_09960	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
N3114_09970	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
N3114_09975	COG1766	The M ring may be actively involved in energy transduction
N3114_09980	COG1815	bacterial-type flagellum-dependent cell motility
N3114_09985	COG4786	Flagellar basal body rod
N3114_09995	COG0745	RESPONSE REGULATOR receiver
N3114_10000	COG4786	Flagellar basal body rod
N3114_10015	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
N3114_10025	COG0228	four-way junction DNA binding
N3114_10030	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
N3114_10035	COG0564	pseudouridine synthase activity
N3114_10040	COG1519	Transferase
N3114_10050	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
N3114_10055	COG0752	glycyl-tRNA synthetase alpha subunit
N3114_10065	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
N3114_10075	COG0826	peptidase U32
N3114_10080	COG0840	transmembrane signaling receptor activity
N3114_10080	COG0840	transmembrane signaling receptor activity
N3114_10085	COG0497	DNA recombination
N3114_10090	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
N3114_10095	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
N3114_10100	COG0049	tRNA binding
N3114_10105	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
N3114_10110	COG1073	alpha beta
N3114_10115	COG2814	Major facilitator Superfamily
N3114_10120	COG4771	TonB-dependent receptor
N3114_10135	COG1116	anion transmembrane transporter activity
N3114_10140	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
N3114_10180	COG0512	Glutamine amidotransferase of anthranilate synthase
N3114_10260	COG1484	DNA-dependent DNA replication
N3114_10305	COG0840	transmembrane signaling receptor activity
N3114_10325	COG1840	ABC-type Fe3 transport system, periplasmic component
N3114_10330	COG1178	ABC-type Fe3 transport system permease component
N3114_10345	COG4774	siderophore transport
N3114_10385	COG2183	response to ionizing radiation
N3114_10395	COG0251	oxidation-reduction process
N3114_10410	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
N3114_10420	COG0586	Pfam SNARE associated Golgi protein
N3114_10425	COG0335	large ribosomal subunit rRNA binding
N3114_10430	COG0336	Belongs to the RNA methyltransferase TrmD family
N3114_10440	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
N3114_10445	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
N3114_10450	COG0356	it plays a direct role in the translocation of protons across the membrane
N3114_10460	COG4773	Receptor
N3114_10470	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
N3114_10480	COG0157	Belongs to the NadC ModD family
N3114_10495	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
N3114_10505	COG0083	homoserine kinase activity
N3114_10515	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
N3114_10520	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
N3114_10525	COG0779	Required for maturation of 30S ribosomal subunits
N3114_10530	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
N3114_10530	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
N3114_10535	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
N3114_10540	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
N3114_10545	COG1185	polyribonucleotide nucleotidyltransferase activity
N3114_10545	COG0539	negative regulation of cytoplasmic translation
N3114_10550	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
N3114_10555	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
N3114_10560	COG0072	phenylalanine-tRNA ligase activity
N3114_10560	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
N3114_10565	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
N3114_10570	COG0537	adenosine 5'-monophosphoramidase activity
N3114_10575	COG0825	malonyl-CoA metabolic process
N3114_10580	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
N3114_10585	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
N3114_10595	COG0602	queuosine metabolic process
N3114_10605	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
N3114_10615	COG1385	rRNA (uridine-N3-)-methyltransferase activity
N3114_10625	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
N3114_10635	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
N3114_10640	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
N3114_10645	COG1074	ATP-dependent DNA helicase activity
N3114_10655	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
N3114_10700	COG3278	Belongs to the heme-copper respiratory oxidase family
N3114_10705	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
N3114_10710	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
N3114_10715	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
N3114_10730	COG1242	4 iron, 4 sulfur cluster binding
N3114_10735	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
N3114_10740	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
N3114_10745	COG0492	ferredoxin-NADP+ reductase activity
N3114_10750	COG3118	belongs to the thioredoxin family
N3114_10755	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
N3114_10780	COG0642	Histidine kinase
N3114_10785	COG0745	RESPONSE REGULATOR receiver
N3114_10795	COG0129	dihydroxy-acid dehydratase activity
N3114_10875	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
N3114_10890	COG0585	pseudouridine synthase activity
N3114_10905	COG0793	Belongs to the peptidase S41A family
N3114_10910	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
N3114_10915	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
N3114_10920	COG0047	phosphoribosylformylglycinamidine synthase activity
N3114_10930	COG0204	Acyl-transferase
N3114_10935	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
N3114_10940	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
N3114_10945	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
N3114_10950	COG0018	arginyl-trna synthetase
N3114_10960	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
N3114_10970	COG0126	phosphoglycerate kinase activity
N3114_10975	COG0149	triose-phosphate isomerase activity
N3114_10980	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
N3114_10985	COG0019	diaminopimelate decarboxylase activity
N3114_10990	COG0077	Prephenate dehydratase
N3114_10990	COG1605	Chorismate mutase
N3114_10995	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
N3114_11000	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
N3114_11010	COG0424	maF-like protein
N3114_11025	COG0791	NLP P60 protein
N3114_11040	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
N3114_11045	COG1012	belongs to the aldehyde dehydrogenase family
N3114_11070	COG0546	phosphoglycolate phosphatase activity
N3114_11075	COG0783	Belongs to the Dps family
N3114_11080	COG2814	Major facilitator Superfamily
N3114_11095	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
N3114_11100	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
N3114_11150	COG1475	DNA binding
N3114_11160	COG0489	protein tyrosine kinase activity
N3114_11255	COG1802	Transcriptional regulator
N3114_11255	COG4626	Terminase
N3114_11270	COG0740	serine-type endopeptidase activity
N3114_11295	COG0740	serine-type endopeptidase activity
N3114_11380	COG1196	nuclear chromosome segregation
N3114_11380	COG0741	lytic transglycosylase activity
N3114_11380	COG0739	heme binding
N3114_11400	COG1484	DNA-dependent DNA replication
N3114_11410	COG1595	DNA-templated transcription, initiation
N3114_11440	COG2081	HI0933 family
N3114_11455	COG1959	2 iron, 2 sulfur cluster binding
N3114_11470	COG0175	sulfate reduction
N3114_11475	COG0175	sulfate reduction
N3114_11480	COG2895	sulfate adenylyltransferase (ATP) activity
N3114_11495	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
N3114_11525	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
N3114_11540	COG4232	protein-disulfide reductase activity
N3114_11545	COG0189	ligase activity
N3114_11560	COG2200	EAL domain
N3114_11560	COG2199	diguanylate cyclase activity
N3114_11560	COG3287	FIST C domain
N3114_11565	COG0688	phosphatidylethanolamine metabolic process
N3114_11575	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
N3114_11580	COG0443	Heat shock 70 kDa protein
N3114_11585	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
N3114_11600	COG0101	tRNA pseudouridine synthase activity
N3114_11615	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
N3114_11620	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
N3114_11625	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
N3114_11640	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
N3114_11655	COG0445	tRNA wobble uridine modification
N3114_11675	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
N3114_11680	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
N3114_11685	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
N3114_11690	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
N3114_11695	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
N3114_11705	COG1252	NADH dehydrogenase
N3114_11715	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
N3114_11725	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
N3114_11740	COG2814	Major facilitator Superfamily
N3114_11745	COG0659	secondary active sulfate transmembrane transporter activity
N3114_11765	COG1222	aaa ATPase
N3114_11775	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
N3114_11780	COG0812	UDP-N-acetylmuramate dehydrogenase activity
N3114_11795	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
N3114_11810	COG0148	phosphopyruvate hydratase activity
N3114_11815	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
N3114_11825	COG1086	Polysaccharide biosynthesis protein
N3114_11830	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
N3114_11840	COG1083	cytidylyl-transferase
N3114_11870	COG1028	Short-chain dehydrogenase reductase Sdr
N3114_11875	COG1028	Short-chain dehydrogenase reductase Sdr
N3114_11880	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
N3114_11900	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
N3114_11905	COG2089	acid synthase
N3114_11945	COG0348	domain, Protein
N3114_11950	COG0504	CTP synthase activity
N3114_11955	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
N3114_11975	COG0587	DNA-directed DNA polymerase activity
N3114_11980	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
N3114_11995	COG0315	cyclic pyranopterin monophosphate synthase activity
N3114_12000	COG0828	Belongs to the bacterial ribosomal protein bS21 family
N3114_12030	COG0670	Belongs to the BI1 family
N3114_12035	COG0352	thiamine-phosphate diphosphorylase activity
N3114_12045	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
N3114_12050	COG0233	cytoplasmic translational termination
N3114_12055	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
N3114_12075	COG3022	response to hydroperoxide
N3114_12090	COG1408	metallophosphoesterase
N3114_12105	COG1609	Transcriptional regulator
N3114_12105	COG2207	Transcriptional regulator
N3114_12110	COG0071	Belongs to the small heat shock protein (HSP20) family
N3114_12115	COG2703	oxygen carrier activity
N3114_12120	COG0840	transmembrane signaling receptor activity
N3114_12145	COG4208	sulfate ABC transporter
N3114_12150	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
N3114_12160	COG2199	diguanylate cyclase activity
N3114_12160	COG2200	EAL domain
N3114_12160	COG3287	FIST C domain
N3114_12190	COG1217	gtp-binding protein TYPA
N3114_12195	COG2391	methyltransferase activity
N3114_12200	COG0425	Belongs to the sulfur carrier protein TusA family
N3114_12210	COG3706	GGDEF domain
N3114_12255	COG0745	RESPONSE REGULATOR receiver
N3114_12260	COG5002	protein histidine kinase activity
N3114_12265	COG2226	methyltransferase
N3114_12275	COG3437	response regulator, receiver
N3114_12275	COG0784	Response regulator, receiver
N3114_12280	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
N3114_12300	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
N3114_12305	COG1192	Involved in chromosome partitioning
N3114_12310	COG1475	DNA binding
N3114_12385	COG1639	'signal transduction protein
N3114_12390	COG0745	RESPONSE REGULATOR receiver
N3114_12405	COG0840	transmembrane signaling receptor activity
N3114_12420	COG1686	Belongs to the peptidase S11 family
N3114_12445	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
N3114_12515	COG1484	DNA-dependent DNA replication
N3114_12595	COG1475	DNA binding
N3114_12720	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis