locus-tag	class	description
N3115_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
N3115_00010	COG0592	DNA-directed DNA polymerase activity
N3115_00015	COG0187	DNA topoisomerase II activity
N3115_00020	COG0492	ferredoxin-NADP+ reductase activity
N3115_00025	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
N3115_00035	COG1238	metal cluster binding
N3115_00040	COG0500	methyltransferase
N3115_00045	COG3842	ATPase activity
N3115_00090	COG0564	pseudouridine synthase activity
N3115_00095	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
N3115_00100	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
N3115_00105	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
N3115_00135	COG0604	alcohol dehydrogenase
N3115_00140	COG1733	regulation of RNA biosynthetic process
N3115_00145	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
N3115_00150	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
N3115_00165	COG1620	l-lactate permease
N3115_00170	COG0745	RESPONSE REGULATOR receiver
N3115_00175	COG3852	Histidine kinase
N3115_00180	COG1556	Lactate utilization protein
N3115_00185	COG1139	Iron-sulfur cluster binding protein
N3115_00190	COG0247	lactate metabolic process
N3115_00195	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
N3115_00200	COG0511	ligase activity, forming carbon-carbon bonds
N3115_00205	COG0439	Biotin carboxylase
N3115_00210	COG0513	Belongs to the DEAD box helicase family
N3115_00215	COG0306	phosphate transporter
N3115_00225	COG0367	asparagine synthase
N3115_00235	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
N3115_00240	COG1981	membrane
N3115_00245	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
N3115_00245	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
N3115_00250	COG1187	pseudouridine synthase activity
N3115_00255	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
N3115_00255	COG0517	IMP dehydrogenase activity
N3115_00260	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
N3115_00265	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
N3115_00270	COG0107	imidazoleglycerol-phosphate synthase activity
N3115_00285	COG0820	rRNA (adenine-C2-)-methyltransferase activity
N3115_00290	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
N3115_00295	COG0724	RNA recognition motif
N3115_00300	COG0745	RESPONSE REGULATOR receiver
N3115_00305	COG0642	Histidine kinase
N3115_00335	COG3328	transposase activity
N3115_00340	COG3328	transposase activity
N3115_00370	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
N3115_00375	COG0291	Belongs to the bacterial ribosomal protein bL35 family
N3115_00380	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
N3115_00395	COG0446	pyridine nucleotide-disulphide oxidoreductase
N3115_00400	COG0746	molybdenum cofactor guanylyltransferase activity
N3115_00405	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
N3115_00410	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
N3115_00415	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
N3115_00420	COG0268	Binds directly to 16S ribosomal RNA
N3115_00425	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
N3115_00435	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
N3115_00440	COG4943	cyclic-guanylate-specific phosphodiesterase activity
N3115_00445	COG0573	inorganic phosphate transmembrane transporter activity
N3115_00450	COG0581	inorganic phosphate transmembrane transporter activity
N3115_00455	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
N3115_00460	COG0704	Plays a role in the regulation of phosphate uptake
N3115_00470	COG0745	RESPONSE REGULATOR receiver
N3115_00475	COG5002	protein histidine kinase activity
N3115_00480	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
N3115_00485	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
N3115_00495	COG0546	phosphoglycolate phosphatase activity
N3115_00515	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
N3115_00520	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
N3115_00525	COG1854	S-ribosylhomocysteine lyase activity
N3115_00540	COG1686	Belongs to the peptidase S11 family
N3115_00555	COG1410	methionine synthase
N3115_00555	COG0646	methionine synthase
N3115_00575	COG0140	phosphoribosyl-ATP diphosphatase activity
N3115_00575	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
N3115_00585	COG0489	protein tyrosine kinase activity
N3115_00590	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
N3115_00600	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
N3115_00600	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
N3115_00610	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
N3115_00620	COG0505	Belongs to the CarA family
N3115_00630	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
N3115_00635	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
N3115_00640	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
N3115_00645	COG2353	YceI-like domain
N3115_00650	COG1846	Transcriptional regulator
N3115_00655	COG2353	YceI-like domain
N3115_00675	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
N3115_00680	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
N3115_00685	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
N3115_00690	COG0237	dephospho-CoA kinase activity
N3115_00695	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
N3115_00700	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
N3115_00705	COG0456	acetyltransferase
N3115_00735	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
N3115_00740	COG0254	rRNA binding
N3115_00745	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
N3115_00760	COG0436	Aminotransferase
N3115_00765	COG0460	homoserine dehydrogenase
N3115_00775	COG0575	Belongs to the CDS family
N3115_00780	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
N3115_00795	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
N3115_00800	COG0023	Translation Initiation Factor
N3115_00805	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
N3115_00805	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
N3115_00810	COG1324	tolerance protein
N3115_00815	COG2022	thiamine diphosphate biosynthetic process
N3115_00890	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
N3115_00895	COG1380	Effector of murein hydrolase LrgA
N3115_00900	COG1346	cytolysis
N3115_00910	COG3766	membrane
N3115_00915	COG1301	dicarboxylic acid transport
N3115_00925	COG0318	PFAM AMP-dependent synthetase and ligase
N3115_00925	COG0204	Acyl-transferase
N3115_00930	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
N3115_00945	COG0666	response to abiotic stimulus
N3115_00955	COG0418	dihydroorotase activity
N3115_00965	COG1706	bacterial-type flagellum-dependent cell motility
N3115_01000	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
N3115_01030	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
N3115_01035	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
N3115_01040	COG0601	transmembrane transport
N3115_01045	COG0736	holo-[acyl-carrier-protein] synthase activity
N3115_01050	COG0786	glutamate:sodium symporter activity
N3115_01055	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
N3115_01065	COG0560	Phosphoserine phosphatase
N3115_01075	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
N3115_01080	COG3248	Nucleoside-binding outer membrane protein
N3115_01085	COG1393	Belongs to the ArsC family
N3115_01090	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
N3115_01095	COG0343	queuine tRNA-ribosyltransferase activity
N3115_01105	COG0436	Aminotransferase
N3115_01125	COG2861	carbohydrate metabolic process
N3115_01130	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
N3115_01135	COG0557	exoribonuclease II activity
N3115_01140	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
N3115_01150	COG0360	Binds together with S18 to 16S ribosomal RNA
N3115_01155	COG0629	single-stranded DNA binding
N3115_01160	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
N3115_01170	COG0215	cysteine-tRNA ligase activity
N3115_01175	COG0195	Participates in both transcription termination and antitermination
N3115_01185	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
N3115_01190	COG2121	Domain of unknown function (DUF374)
N3115_01200	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
N3115_01210	COG0288	reversible hydration of carbon dioxide
N3115_01215	COG0156	8-amino-7-oxononanoate synthase activity
N3115_01220	COG0792	nuclease activity
N3115_01240	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
N3115_01250	COG0540	Belongs to the ATCase OTCase family
N3115_01255	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
N3115_01275	COG3328	transposase activity
N3115_01285	COG2824	Alkylphosphonate utilization operon protein PhnA
N3115_01290	COG1451	nucleotide metabolic process
N3115_01295	COG0730	response to heat
N3115_01320	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
N3115_01330	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
N3115_01335	COG0372	Belongs to the citrate synthase family
N3115_01340	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
N3115_01345	COG2828	Protein conserved in bacteria
N3115_01355	COG1335	isochorismatase
N3115_01360	COG0181	hydroxymethylbilane synthase activity
N3115_01370	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
N3115_01375	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
N3115_01380	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
N3115_01385	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
N3115_01390	COG0450	alkyl hydroperoxide reductase
N3115_01400	COG0105	UTP biosynthetic process
N3115_01410	COG0333	Belongs to the bacterial ribosomal protein bL32 family
N3115_01415	COG0416	fatty acid biosynthetic process
N3115_01420	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
N3115_01440	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
N3115_01445	COG1053	succinate dehydrogenase
N3115_01455	COG1007	ATP synthesis coupled electron transport
N3115_01465	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
N3115_01470	COG0713	ATP synthesis coupled electron transport
N3115_01475	COG0839	Belongs to the complex I subunit 6 family
N3115_01480	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
N3115_01485	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
N3115_01490	COG1034	ATP synthesis coupled electron transport
N3115_01495	COG0372	Belongs to the citrate synthase family
N3115_01510	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
N3115_01510	COG0649	NAD binding
N3115_01515	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
N3115_01520	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
N3115_01525	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
N3115_01530	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
N3115_01535	COG3610	response to peptide
N3115_01540	COG2966	Psort location CytoplasmicMembrane, score
N3115_01555	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
N3115_01580	COG4774	siderophore transport
N3115_01590	COG1971	Probably functions as a manganese efflux pump
N3115_01605	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
N3115_01610	COG1333	cytochrome c biogenesis protein
N3115_01610	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
N3115_01615	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
N3115_01620	COG3005	denitrification pathway
N3115_01630	COG2199	diguanylate cyclase activity
N3115_01630	COG3287	FIST C domain
N3115_01630	COG2200	EAL domain
N3115_01635	COG0840	transmembrane signaling receptor activity
N3115_01655	COG3043	anaerobic respiration
N3115_01660	COG0348	domain, Protein
N3115_01665	COG0437	4 iron, 4 sulfur cluster binding
N3115_01670	COG0243	molybdopterin cofactor binding
N3115_01680	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
N3115_01685	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
N3115_01695	COG2204	response regulator
N3115_01700	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
N3115_01705	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
N3115_01705	COG1648	precorrin-2 dehydrogenase activity
N3115_01720	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
N3115_01725	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
N3115_01730	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
N3115_01740	COG2404	hydrolase activity, acting on ester bonds
N3115_01745	COG1832	CoA-binding protein
N3115_01750	COG0642	Histidine kinase
N3115_01755	COG0745	RESPONSE REGULATOR receiver
N3115_01760	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
N3115_01765	COG0191	fructose-bisphosphate aldolase activity
N3115_01785	COG0811	peptide transport
N3115_01795	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
N3115_01800	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
N3115_01810	COG0142	geranyltranstransferase activity
N3115_01815	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
N3115_01820	COG0442	prolyl-tRNA aminoacylation
N3115_01825	COG0668	transmembrane transport
N3115_01830	COG0617	tRNA 3'-terminal CCA addition
N3115_01845	COG0815	Transfers the fatty acyl group on membrane lipoproteins
N3115_01850	COG1862	Preprotein translocase
N3115_01855	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
N3115_01860	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
N3115_01875	COG1360	Flagellar Motor Protein
N3115_01880	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
N3115_01890	COG0495	leucyl-tRNA aminoacylation
N3115_01900	COG0285	dihydrofolate synthase activity
N3115_01930	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
N3115_01950	COG0745	RESPONSE REGULATOR receiver
N3115_01955	COG0642	Histidine kinase
N3115_01960	COG2081	HI0933 family
N3115_01965	COG0840	transmembrane signaling receptor activity
N3115_01980	COG5002	protein histidine kinase activity
N3115_01985	COG1692	metallophosphoesterase
N3115_02025	COG2226	methyltransferase
N3115_02030	COG1570	exodeoxyribonuclease VII activity
N3115_02035	COG0835	chemotaxis
N3115_02040	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
N3115_02045	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
N3115_02050	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
N3115_02060	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
N3115_02065	COG0459	protein refolding
N3115_02080	COG1408	metallophosphoesterase
N3115_02105	COG1136	(ABC) transporter
N3115_02125	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
N3115_02130	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
N3115_02135	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
N3115_02140	COG0352	thiamine-phosphate diphosphorylase activity
N3115_02145	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
N3115_02155	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
N3115_02160	COG2264	protein methyltransferase activity
N3115_02165	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
N3115_02180	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
N3115_02195	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
N3115_02225	COG2274	protein secretion by the type I secretion system
N3115_02245	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
N3115_02255	COG1090	epimerase
N3115_02260	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
N3115_02275	COG0481	GTPase activity
N3115_02280	COG1937	Protein conserved in bacteria
N3115_02290	COG2608	mercury ion transmembrane transporter activity
N3115_02300	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
N3115_02310	COG0482	sulfurtransferase activity
N3115_02315	COG0482	sulfurtransferase activity
N3115_02320	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
N3115_02325	COG0006	proline dipeptidase activity
N3115_02330	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
N3115_02335	COG0402	S-adenosylhomocysteine deaminase activity
N3115_02340	COG0616	signal peptide processing
N3115_02350	COG0280	phosphate acetyltransferase
N3115_02355	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
N3115_02365	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
N3115_02370	COG2176	DNA-directed DNA polymerase activity
N3115_02400	COG2176	DNA-directed DNA polymerase activity
N3115_02410	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
N3115_02425	COG5002	protein histidine kinase activity
N3115_02470	COG1058	Belongs to the CinA family
N3115_02470	COG1546	Belongs to the CinA family
N3115_02475	COG0579	oxidoreductase
N3115_02480	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
N3115_02495	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
N3115_02510	COG0667	Aldo Keto reductase
N3115_02515	COG0306	phosphate transporter
N3115_02530	COG0840	transmembrane signaling receptor activity
N3115_02535	COG0824	Thioesterase
N3115_02545	COG0501	Belongs to the peptidase M48B family
N3115_02550	COG1322	Protein conserved in bacteria
N3115_02570	COG0037	tRNA processing
N3115_02590	COG0052	Belongs to the universal ribosomal protein uS2 family
N3115_02595	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
N3115_02600	COG1136	(ABC) transporter
N3115_02610	COG0194	GDP metabolic process
N3115_02615	COG5001	Diguanylate cyclase
N3115_02615	COG5002	protein histidine kinase activity
N3115_02620	COG2217	Heavy metal translocating P-type atpase
N3115_02635	COG4608	Belongs to the ABC transporter superfamily
N3115_02640	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
N3115_02645	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
N3115_02655	COG1434	Gram-negative-bacterium-type cell wall biogenesis
N3115_02660	COG1121	(ABC) transporter
N3115_02665	COG1108	ABC-type Mn2 Zn2 transport systems permease components
N3115_02670	COG2996	Protein conserved in bacteria
N3115_02675	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
N3115_02695	COG0210	DNA helicase
N3115_02700	COG0475	glutathione-regulated potassium exporter activity
N3115_02700	COG0569	domain protein
N3115_02705	COG0525	valine-tRNA ligase activity
N3115_02715	COG4895	conserved protein (DUF2196)
N3115_02725	COG2814	Major facilitator Superfamily
N3115_02730	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
N3115_02750	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
N3115_02755	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
N3115_02760	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
N3115_02770	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
N3115_02805	COG0439	Biotin carboxylase
N3115_02810	COG2151	metal-sulfur cluster biosynthetic enzyme
N3115_02815	COG2166	iron-sulfur cluster assembly
N3115_02820	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
N3115_02830	COG0396	ATPase activity
N3115_02835	COG0719	Fe-S assembly protein
N3115_02845	COG0822	iron-sulfur transferase activity
N3115_02845	COG2906	2 iron, 2 sulfur cluster binding
N3115_02845	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
N3115_02850	COG2239	Acts as a magnesium transporter
N3115_02855	COG3706	GGDEF domain
N3115_02860	COG0165	Argininosuccinate lyase
N3115_02865	COG0784	Response regulator, receiver
N3115_02865	COG0835	chemotaxis
N3115_02870	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
N3115_02875	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
N3115_02885	COG0556	nucleotide-excision repair
N3115_02890	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
N3115_02910	COG3328	transposase activity
N3115_02920	COG0840	transmembrane signaling receptor activity
N3115_02955	COG0698	ribose 5-phosphate isomerase
N3115_02960	COG0681	Belongs to the peptidase S26 family
N3115_02965	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
N3115_02970	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
N3115_02975	COG0193	aminoacyl-tRNA hydrolase activity
N3115_02990	COG0860	N-Acetylmuramoyl-L-alanine amidase
N3115_03000	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
N3115_03005	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
N3115_03015	COG0528	UMP kinase activity
N3115_03025	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
N3115_03030	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
N3115_03035	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
N3115_03045	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
N3115_03050	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
N3115_03060	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
N3115_03070	COG0305	Participates in initiation and elongation during chromosome replication
N3115_03085	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
N3115_03095	COG2089	acid synthase
N3115_03100	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
N3115_03110	COG1083	cytidylyl-transferase
N3115_03115	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
N3115_03125	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
N3115_03145	COG1028	Short-chain dehydrogenase reductase Sdr
N3115_03160	COG0110	maltose O-acetyltransferase activity
N3115_03190	COG1086	Polysaccharide biosynthesis protein
N3115_03215	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
N3115_03220	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
N3115_03225	COG1086	Polysaccharide biosynthesis protein
N3115_03235	COG1793	dna ligase
N3115_03240	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
N3115_03245	COG0133	tryptophan synthase activity
N3115_03255	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
N3115_03265	COG0848	biopolymer transport protein
N3115_03285	COG0577	efflux transmembrane transporter activity
N3115_03285	COG1136	(ABC) transporter
N3115_03290	COG0577	efflux transmembrane transporter activity
N3115_03290	COG1136	(ABC) transporter
N3115_03335	COG0735	belongs to the Fur family
N3115_03345	COG0114	fumarate hydratase activity
N3115_03355	COG3920	Histidine kinase
N3115_03360	COG0784	Response regulator, receiver
N3115_03365	COG4771	TonB-dependent receptor
N3115_03385	COG1966	Carbon starvation protein
N3115_03390	COG0012	GTP binding
N3115_03410	COG3123	guanosine phosphorylase activity
N3115_03420	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
N3115_03425	COG0585	pseudouridine synthase activity
N3115_03435	COG0840	transmembrane signaling receptor activity
N3115_03440	COG0632	four-way junction helicase activity
N3115_03445	COG1181	Belongs to the D-alanine--D-alanine ligase family
N3115_03470	COG0051	transcription antitermination factor activity, RNA binding
N3115_03475	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
N3115_03480	COG0088	Forms part of the polypeptide exit tunnel
N3115_03485	COG0089	rRNA binding
N3115_03490	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
N3115_03495	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
N3115_03500	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
N3115_03505	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
N3115_03510	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
N3115_03515	COG0255	Belongs to the universal ribosomal protein uL29 family
N3115_03520	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
N3115_03525	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
N3115_03530	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
N3115_03535	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
N3115_03540	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
N3115_03545	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
N3115_03550	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
N3115_03555	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
N3115_03560	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
N3115_03565	COG0200	Binds to the 23S rRNA
N3115_03570	COG0201	protein transport
N3115_03575	COG0024	Methionine aminopeptidase
N3115_03580	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
N3115_03585	COG1573	uracil-dna glycosylase
N3115_03595	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
N3115_03605	COG1032	radical SAM domain protein
N3115_03615	COG0563	adenylate kinase activity
N3115_03625	COG1064	alcohol dehydrogenase
N3115_03630	COG1979	alcohol dehydrogenase
N3115_03635	COG0840	transmembrane signaling receptor activity
N3115_03640	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
N3115_03645	COG0322	excinuclease ABC activity
N3115_03650	COG0840	transmembrane signaling receptor activity
N3115_03655	COG0745	RESPONSE REGULATOR receiver
N3115_03665	COG2205	protein histidine kinase activity
N3115_03665	COG0784	Response regulator, receiver
N3115_03710	COG0829	nickel cation binding
N3115_03715	COG0832	Belongs to the urease beta subunit family
N3115_03715	COG0831	urea catabolic process
N3115_03720	COG0804	urea catabolic process
N3115_03725	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
N3115_03735	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
N3115_03780	COG0708	Exodeoxyribonuclease III
N3115_03805	COG3040	lipid binding
N3115_03820	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
N3115_03830	COG2200	EAL domain
N3115_03835	COG3279	Response regulator of the LytR AlgR family
N3115_03840	COG3275	phosphorelay sensor kinase activity
N3115_03845	COG1233	COG1233 Phytoene dehydrogenase and related
N3115_03850	COG0415	Belongs to the DNA photolyase family
N3115_03870	COG0166	Belongs to the GPI family
N3115_03915	COG0840	transmembrane signaling receptor activity
N3115_03920	COG1942	4-Oxalocrotonate Tautomerase
N3115_03925	COG0583	DNA-binding transcription factor activity
N3115_03930	COG0134	indole-3-glycerol-phosphate synthase activity
N3115_03940	COG0727	PFAM Uncharacterised protein family (UPF0153)
N3115_03945	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
N3115_03955	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
N3115_03955	COG0674	pyruvate-flavodoxin oxidoreductase activity
N3115_03960	COG1013	pyruvate-flavodoxin oxidoreductase activity
N3115_03970	COG2176	DNA-directed DNA polymerase activity
N3115_03975	COG0135	phosphoribosylanthranilate isomerase activity
N3115_03980	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
N3115_04000	COG1666	GTP binding
N3115_04010	COG2363	Small membrane protein
N3115_04015	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
N3115_04030	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
N3115_04035	COG0750	zinc metalloprotease
N3115_04040	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
N3115_04045	COG1028	Short-chain dehydrogenase reductase Sdr
N3115_04050	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
N3115_04060	COG0167	dihydroorotate dehydrogenase activity
N3115_04065	COG1132	(ABC) transporter
N3115_04070	COG0728	peptidoglycan biosynthetic process
N3115_04085	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
N3115_04095	COG3340	Belongs to the peptidase S51 family
N3115_04100	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
N3115_04105	COG3150	esterase
N3115_04115	COG0552	protein localization to endoplasmic reticulum
N3115_04120	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
N3115_04125	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
N3115_04130	COG1418	mRNA catabolic process
N3115_04135	COG0742	ribosomal rna small subunit methyltransferase
N3115_04140	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
N3115_04165	COG0300	oxidoreductase activity
N3115_04185	COG3258	Cytochrome c
N3115_04195	COG0745	RESPONSE REGULATOR receiver
N3115_04200	COG0642	Histidine kinase
N3115_04205	COG0157	Belongs to the NadC ModD family
N3115_04215	COG1610	YqeY-like protein
N3115_04220	COG0488	(ABC) transporter
N3115_04230	COG0492	ferredoxin-NADP+ reductase activity
N3115_04235	COG0596	Alpha beta hydrolase
N3115_04270	COG2336	PFAM SpoVT AbrB
N3115_04285	COG0518	GMP synthase (glutamine-hydrolyzing) activity
N3115_04285	COG0519	Catalyzes the synthesis of GMP from XMP
N3115_04290	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
N3115_04300	COG1451	nucleotide metabolic process
N3115_04305	COG0436	Aminotransferase
N3115_04310	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
N3115_04345	COG1696	Membrane protein involved in D-alanine export
N3115_04355	COG2223	nitrite transmembrane transporter activity
N3115_04365	COG0310	cobalt ion transport
N3115_04410	COG0628	permease
N3115_04435	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
N3115_04445	COG0840	transmembrane signaling receptor activity
N3115_04450	COG0730	response to heat
N3115_04455	COG1045	serine acetyltransferase
N3115_04460	COG1166	arginine decarboxylase activity
N3115_04465	COG0124	histidyl-tRNA synthetase
N3115_04470	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
N3115_04475	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
N3115_04480	COG0163	prenyltransferase activity
N3115_04490	COG0359	binds to the 23S rRNA
N3115_04495	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
N3115_04500	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
N3115_04510	COG0084	hydrolase, TatD family'
N3115_04520	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
N3115_04525	COG0131	Imidazoleglycerol-phosphate dehydratase
N3115_04530	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
N3115_04545	COG0218	Necessary for normal cell division and for the maintenance of normal septation
N3115_04550	COG0456	acetyltransferase
N3115_04570	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
N3115_04575	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
N3115_04600	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
N3115_04610	COG0784	Response regulator, receiver
N3115_04610	COG3437	response regulator, receiver
N3115_04620	COG0768	penicillin binding
N3115_04640	COG2884	Cell division ATP-binding protein ftsE
N3115_04645	COG0220	tRNA (guanine-N7-)-methyltransferase activity
N3115_04655	COG0564	pseudouridine synthase activity
N3115_04660	COG0772	Belongs to the SEDS family
N3115_04670	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
N3115_04675	COG3123	guanosine phosphorylase activity
N3115_04695	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
N3115_04700	COG0066	3-isopropylmalate dehydratase activity
N3115_04705	COG0473	3-isopropylmalate dehydrogenase activity
N3115_04720	COG0257	Belongs to the bacterial ribosomal protein bL36 family
N3115_04725	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
N3115_04730	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
N3115_04735	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
N3115_04740	COG0202	RNA polymerase activity
N3115_04745	COG0203	ribosomal protein L17
N3115_04750	COG0154	amidase activity
N3115_04755	COG0516	GMP reductase activity
N3115_04755	COG0517	IMP dehydrogenase activity
N3115_04770	COG0484	heat shock protein binding
N3115_04785	COG1119	ATPase activity
N3115_04810	COG1733	regulation of RNA biosynthetic process
N3115_04815	COG2249	NAD(P)H dehydrogenase (quinone) activity
N3115_04825	COG2076	Multidrug Resistance protein
N3115_04840	COG1881	PFAM PEBP family protein
N3115_04845	COG0583	DNA-binding transcription factor activity
N3115_04850	COG2855	membrane
N3115_04880	COG1733	regulation of RNA biosynthetic process
N3115_04885	COG2249	NAD(P)H dehydrogenase (quinone) activity
N3115_04890	COG0778	Nitroreductase
N3115_04915	COG0778	Nitroreductase
N3115_04925	COG0488	(ABC) transporter
N3115_04930	COG1607	acyl-coa hydrolase
N3115_04940	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
N3115_04945	COG0754	glutathionylspermidine amidase activity
N3115_04985	COG0732	type I restriction modification DNA specificity domain
N3115_05025	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
N3115_05045	COG3328	transposase activity
N3115_05050	COG0840	transmembrane signaling receptor activity
N3115_05060	COG1639	'signal transduction protein
N3115_05065	COG0745	RESPONSE REGULATOR receiver
N3115_05080	COG0840	transmembrane signaling receptor activity
N3115_05105	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
N3115_05110	COG0420	3'-5' exonuclease activity
N3115_05115	COG0419	ATPase involved in DNA repair
N3115_05160	COG0514	ATP-dependent DNA helicase (RecQ)
N3115_05255	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
N3115_05265	COG1496	oxidoreductase activity
N3115_05270	COG0281	malic enzyme
N3115_05270	COG0280	phosphate acetyltransferase
N3115_05275	COG0788	formyltetrahydrofolate deformylase activity
N3115_05280	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
N3115_05305	COG0745	RESPONSE REGULATOR receiver
N3115_05315	COG0330	HflC and HflK could
N3115_05340	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
N3115_05345	COG1187	pseudouridine synthase activity
N3115_05350	COG0546	phosphoglycolate phosphatase activity
N3115_05380	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
N3115_05390	COG0406	alpha-ribazole phosphatase activity
N3115_05395	COG1132	(ABC) transporter
N3115_05405	COG0745	RESPONSE REGULATOR receiver
N3115_05410	COG0642	Histidine kinase
N3115_05425	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
N3115_05435	COG0513	Belongs to the DEAD box helicase family
N3115_05445	COG0745	RESPONSE REGULATOR receiver
N3115_05480	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
N3115_05490	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
N3115_05495	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
N3115_05505	COG0521	Mo-molybdopterin cofactor biosynthetic process
N3115_05560	COG0243	molybdopterin cofactor binding
N3115_05575	COG1193	negative regulation of DNA recombination
N3115_05580	COG1253	flavin adenine dinucleotide binding
N3115_05590	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
N3115_05595	COG0004	ammonium transporteR
N3115_05620	COG0028	Belongs to the TPP enzyme family
N3115_05625	COG0440	acetolactate synthase activity
N3115_05630	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
N3115_05635	COG1196	nuclear chromosome segregation
N3115_05635	COG1674	ftsk spoiiie
N3115_05640	COG0745	RESPONSE REGULATOR receiver
N3115_05645	COG0642	Histidine kinase
N3115_05655	COG3012	SEC-C Motif Domain Protein
N3115_05665	COG1160	GTP binding
N3115_05670	COG0659	secondary active sulfate transmembrane transporter activity
N3115_05690	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
N3115_05700	COG1185	polyribonucleotide nucleotidyltransferase activity
N3115_05710	COG0643	Histidine kinase
N3115_05710	COG2198	Histidine kinase
N3115_05715	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
N3115_05720	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
N3115_05725	COG2201	protein-glutamate methylesterase activity
N3115_05735	COG2223	nitrite transmembrane transporter activity
N3115_05740	COG0582	viral genome integration into host DNA
N3115_05760	COG0339	signal peptide processing
N3115_05765	COG2890	protein-(glutamine-N5) methyltransferase activity
N3115_05770	COG0635	Involved in the biosynthesis of porphyrin-containing compound
N3115_05775	COG0494	nUDIX hydrolase
N3115_05780	COG0527	aspartate kinase activity
N3115_05795	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
N3115_05800	COG0287	Prephenate dehydrogenase
N3115_05805	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
N3115_05810	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
N3115_05815	COG0612	Peptidase, M16
N3115_05820	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
N3115_05845	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
N3115_05855	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
N3115_05855	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
N3115_05880	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
N3115_05905	COG0751	glycine-tRNA ligase activity
N3115_05925	COG0357	Ribosomal RNA small subunit methyltransferase G
N3115_05930	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
N3115_05935	COG0113	porphobilinogen synthase activity
N3115_05945	COG0745	RESPONSE REGULATOR receiver
N3115_05960	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
N3115_05960	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
N3115_05965	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
N3115_05970	COG0635	Involved in the biosynthesis of porphyrin-containing compound
N3115_05985	COG1663	tetraacyldisaccharide 4'-kinase activity
N3115_05995	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
N3115_06015	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
N3115_06020	COG0805	protein transport
N3115_06025	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
N3115_06030	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
N3115_06065	COG0247	lactate metabolic process
N3115_06065	COG2181	nitrate reductase activity
N3115_06070	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
N3115_06090	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
N3115_06095	COG3287	FIST C domain
N3115_06095	COG2199	diguanylate cyclase activity
N3115_06095	COG2200	EAL domain
N3115_06100	COG1137	ATPase activity
N3115_06105	COG0802	atpase or kinase
N3115_06110	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
N3115_06125	COG0137	argininosuccinate synthase activity
N3115_06130	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
N3115_06135	COG1696	Membrane protein involved in D-alanine export
N3115_06150	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
N3115_06160	COG0569	domain protein
N3115_06165	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
N3115_06170	COG0745	RESPONSE REGULATOR receiver
N3115_06175	COG2205	protein histidine kinase activity
N3115_06190	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
N3115_06195	COG0484	heat shock protein binding
N3115_06200	COG0133	tryptophan synthase activity
N3115_06220	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
N3115_06230	COG2199	diguanylate cyclase activity
N3115_06235	COG0500	methyltransferase
N3115_06245	COG1333	cytochrome c biogenesis protein
N3115_06245	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
N3115_06250	COG2195	Cleaves the N-terminal amino acid of tripeptides
N3115_06275	COG0653	protein targeting
N3115_06280	COG4591	ABC-type transport system involved in lipoprotein release permease component
N3115_06290	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
N3115_06300	COG0039	L-malate dehydrogenase activity
N3115_06325	COG0275	rRNA processing
N3115_06335	COG0776	regulation of translation
N3115_06345	COG1959	2 iron, 2 sulfur cluster binding
N3115_06360	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
N3115_06360	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
N3115_06370	COG2201	protein-glutamate methylesterase activity
N3115_06385	COG0484	heat shock protein binding
N3115_06390	COG0789	Transcriptional regulator
N3115_06400	COG1131	(ABC) transporter
N3115_06405	COG0842	Transport permease protein
N3115_06410	COG0842	Transport permease protein
N3115_06415	COG0861	Integral membrane protein TerC family
N3115_06420	COG1114	Component of the transport system for branched-chain amino acids
N3115_06440	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
N3115_06450	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
N3115_06460	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
N3115_06470	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
N3115_06515	COG0488	(ABC) transporter
N3115_06525	COG2171	N-acyltransferase activity
N3115_06530	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
N3115_06540	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
N3115_06570	COG0309	Hydrogenase expression formation protein (HypE)
N3115_06580	COG2084	Dehydrogenase
N3115_06590	COG0409	Hydrogenase expression formation protein
N3115_06595	COG0298	carbon dioxide binding
N3115_06600	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
N3115_06610	COG0840	transmembrane signaling receptor activity
N3115_06620	COG2081	HI0933 family
N3115_06625	COG2354	Protein conserved in bacteria
N3115_06640	COG2814	Major facilitator Superfamily
N3115_06650	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
N3115_06650	COG0301	tRNA thio-modification
N3115_06670	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
N3115_06675	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
N3115_06680	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
N3115_06685	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
N3115_06690	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
N3115_06695	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
N3115_06710	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
N3115_06725	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
N3115_06730	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
N3115_06745	COG1309	transcriptional regulator
N3115_06750	COG1049	propionate catabolic process, 2-methylcitrate cycle
N3115_06760	COG2203	Gaf domain
N3115_06760	COG3706	GGDEF domain
N3115_06760	COG4251	negative regulation of phosphorylation
N3115_06760	COG5001	Diguanylate cyclase
N3115_06765	COG0217	transcriptional regulatory protein
N3115_06770	COG2853	Lipoprotein
N3115_06785	COG1611	Belongs to the LOG family
N3115_06790	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
N3115_06805	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
N3115_06825	COG4774	siderophore transport
N3115_06860	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
N3115_06885	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
N3115_06890	COG2258	MOSC domain
N3115_06895	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
N3115_06900	COG0095	Lipoate-protein ligase
N3115_06905	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
N3115_06910	COG0508	dehydrogenase complex catalyzes the overall conversion of
N3115_06915	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
N3115_06920	COG1492	cobalamin metabolic process
N3115_06930	COG4773	Receptor
N3115_06960	COG0840	transmembrane signaling receptor activity
N3115_06965	COG0328	RNA-DNA hybrid ribonuclease activity
N3115_06970	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
N3115_07000	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
N3115_07010	COG0437	4 iron, 4 sulfur cluster binding
N3115_07065	COG1305	Transglutaminase-like
N3115_07070	COG0709	Synthesizes selenophosphate from selenide and ATP
N3115_07090	COG3328	transposase activity
N3115_07110	COG0840	transmembrane signaling receptor activity
N3115_07115	COG0840	transmembrane signaling receptor activity
N3115_07155	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
N3115_07160	COG0732	type I restriction modification DNA specificity domain
N3115_07225	COG0582	viral genome integration into host DNA
N3115_07235	COG1921	L-seryl-tRNASec selenium transferase activity
N3115_07300	COG1078	dGTPase activity
N3115_07305	COG5002	protein histidine kinase activity
N3115_07305	COG5001	Diguanylate cyclase
N3115_07310	COG0259	pyridoxamine-phosphate oxidase activity
N3115_07320	COG0513	Belongs to the DEAD box helicase family
N3115_07345	COG0326	Molecular chaperone. Has ATPase activity
N3115_07350	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
N3115_07370	COG2995	paraquat-inducible protein a
N3115_07385	COG5002	protein histidine kinase activity
N3115_07385	COG5001	Diguanylate cyclase
N3115_07415	COG4335	DNA alkylation repair
N3115_07420	COG2329	Antibiotic biosynthesis monooxygenase
N3115_07445	COG0010	Belongs to the arginase family
N3115_07460	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
N3115_07470	COG0519	Catalyzes the synthesis of GMP from XMP
N3115_07475	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
N3115_07480	COG0668	transmembrane transport
N3115_07485	COG1227	inorganic diphosphatase activity
N3115_07500	COG1027	Aspartate ammonia-lyase
N3115_07505	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
N3115_07510	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
N3115_07515	COG1047	Peptidyl-prolyl cis-trans
N3115_07530	COG0823	Involved in the tonB-independent uptake of proteins
N3115_07540	COG0848	biopolymer transport protein
N3115_07545	COG0811	peptide transport
N3115_07550	COG0355	proton-transporting ATP synthase activity, rotational mechanism
N3115_07555	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
N3115_07560	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
N3115_07565	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
N3115_07570	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
N3115_07575	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
N3115_07585	COG1475	DNA binding
N3115_07590	COG1192	Involved in chromosome partitioning
N3115_07605	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
N3115_07610	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
N3115_07615	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
N3115_07620	COG0211	Belongs to the bacterial ribosomal protein bL27 family
N3115_07625	COG0261	This protein binds to 23S rRNA in the presence of protein L20
N3115_07630	COG0358	DNA primase activity
N3115_07640	COG0571	ribonuclease III activity
N3115_07645	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
N3115_07655	COG0501	Belongs to the peptidase M48B family
N3115_07675	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
N3115_07685	COG0706	membrane insertase activity
N3115_07690	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
N3115_07695	COG0594	ribonuclease P activity
N3115_07700	COG0230	Belongs to the bacterial ribosomal protein bL34 family
N3115_07705	COG0542	response to heat
N3115_07710	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
N3115_07720	COG2326	polyphosphate kinase activity
N3115_07730	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
N3115_07735	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
N3115_07740	COG0179	Fumarylacetoacetate (FAA) hydrolase
N3115_07765	COG0138	bifunctional purine biosynthesis protein purh
N3115_07770	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
N3115_07780	COG0739	heme binding
N3115_07785	COG0302	gtp cyclohydrolase
N3115_07790	COG0598	Magnesium transport protein CorA
N3115_07815	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
N3115_07820	COG0606	chelatase, subunit chli
N3115_07825	COG0840	transmembrane signaling receptor activity
N3115_07840	COG0242	peptide deformylase activity
N3115_07845	COG0740	serine-type endopeptidase activity
N3115_07850	COG0544	peptidyl-prolyl cis-trans isomerase activity
N3115_07895	COG0626	cystathionine gamma-synthase activity
N3115_07910	COG0840	transmembrane signaling receptor activity
N3115_07945	COG0745	RESPONSE REGULATOR receiver
N3115_07955	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
N3115_07970	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
N3115_07975	COG1858	cytochrome C peroxidase
N3115_08005	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
N3115_08030	COG0351	phosphomethylpyrimidine kinase
N3115_08035	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
N3115_08050	COG0348	domain, Protein
N3115_08060	COG2207	Transcriptional regulator
N3115_08060	COG4753	response regulator
N3115_08075	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
N3115_08095	COG0716	FMN binding
N3115_08110	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
N3115_08115	COG0159	tryptophan synthase activity
N3115_08120	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
N3115_08125	COG2255	four-way junction helicase activity
N3115_08130	COG0628	permease
N3115_08170	COG0731	radical SAM domain protein
N3115_08175	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
N3115_08185	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
N3115_08200	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
N3115_08210	COG0227	Belongs to the bacterial ribosomal protein bL28 family
N3115_08220	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
N3115_08230	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
N3115_08230	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
N3115_08235	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
N3115_08240	COG1368	sulfuric ester hydrolase activity
N3115_08245	COG0859	PFAM glycosyl transferase family 9
N3115_08255	COG0859	PFAM glycosyl transferase family 9
N3115_08260	COG0463	Glycosyl transferase, family 2
N3115_08275	COG0438	transferase activity, transferring glycosyl groups
N3115_08295	COG1696	Membrane protein involved in D-alanine export
N3115_08305	COG1696	Membrane protein involved in D-alanine export
N3115_08315	COG1696	Membrane protein involved in D-alanine export
N3115_08370	COG0859	PFAM glycosyl transferase family 9
N3115_08380	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
N3115_08390	COG0493	'glutamate synthase
N3115_08395	COG0069	glutamate synthase activity
N3115_08395	COG0070	glutamate synthase
N3115_08395	COG0067	glutamate synthase
N3115_08420	COG1739	Uncharacterized protein family UPF0029
N3115_08430	COG0196	riboflavin kinase activity
N3115_08435	COG2226	methyltransferase
N3115_08440	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
N3115_08450	COG0277	FAD linked oxidase domain protein
N3115_08455	COG1295	ribonuclease BN
N3115_08465	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
N3115_08475	COG2877	3-deoxy-8-phosphooctulonate synthase activity
N3115_08480	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
N3115_08485	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
N3115_08490	COG0284	orotidine-5'-phosphate decarboxylase activity
N3115_08520	COG1918	ferrous iron import across plasma membrane
N3115_08525	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
N3115_08525	COG1918	ferrous iron import across plasma membrane
N3115_08550	COG2217	Heavy metal translocating P-type atpase
N3115_08560	COG4773	Receptor
N3115_08570	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
N3115_08585	COG1278	Cold shock
N3115_08595	COG4753	response regulator
N3115_08595	COG2207	Transcriptional regulator
N3115_08600	COG3852	Histidine kinase
N3115_08635	COG0450	alkyl hydroperoxide reductase
N3115_08640	COG3118	belongs to the thioredoxin family
N3115_08655	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
N3115_08660	COG0085	RNA polymerase activity
N3115_08665	COG0222	ribosome binding
N3115_08670	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
N3115_08675	COG0081	regulation of translation
N3115_08680	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
N3115_08685	COG0250	Participates in transcription elongation, termination and antitermination
N3115_08700	COG0267	Belongs to the bacterial ribosomal protein bL33 family
N3115_08705	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
N3115_08735	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
N3115_08740	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
N3115_08745	COG0444	Belongs to the ABC transporter superfamily
N3115_08750	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
N3115_08755	COG0174	glutamine synthetase
N3115_08765	COG0314	molybdopterin synthase activity
N3115_08775	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
N3115_08780	COG1968	undecaprenyl-diphosphatase activity
N3115_08785	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
N3115_08790	COG0772	Belongs to the SEDS family
N3115_08800	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
N3115_08840	COG0542	response to heat
N3115_08845	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
N3115_08850	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
N3115_08865	COG2030	dehydratase
N3115_08885	COG0840	transmembrane signaling receptor activity
N3115_08890	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
N3115_08910	COG2059	Chromate
N3115_08920	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
N3115_08930	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
N3115_08935	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
N3115_08940	COG1157	protein secretion by the type III secretion system
N3115_08950	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
N3115_08970	COG1677	Flagellar hook-basal body complex protein FliE
N3115_08980	COG0455	bacterial-type flagellum organization
N3115_08985	COG1419	protein localization to endoplasmic reticulum
N3115_09000	COG3951	Flagellar rod assembly protein muramidase FlgJ
N3115_09025	COG1749	Flagellar hook protein flgE
N3115_09030	COG4786	Flagellar basal body rod
N3115_09040	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
N3115_09050	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
N3115_09055	COG1766	The M ring may be actively involved in energy transduction
N3115_09060	COG1815	bacterial-type flagellum-dependent cell motility
N3115_09065	COG4786	Flagellar basal body rod
N3115_09075	COG0745	RESPONSE REGULATOR receiver
N3115_09095	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
N3115_09105	COG0228	four-way junction DNA binding
N3115_09110	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
N3115_09115	COG0564	pseudouridine synthase activity
N3115_09120	COG1519	Transferase
N3115_09130	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
N3115_09135	COG0752	glycyl-tRNA synthetase alpha subunit
N3115_09145	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
N3115_09155	COG0826	peptidase U32
N3115_09160	COG0840	transmembrane signaling receptor activity
N3115_09160	COG0840	transmembrane signaling receptor activity
N3115_09165	COG0497	DNA recombination
N3115_09170	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
N3115_09175	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
N3115_09180	COG0049	tRNA binding
N3115_09185	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
N3115_09195	COG2814	Major facilitator Superfamily
N3115_09200	COG4771	TonB-dependent receptor
N3115_09215	COG1116	anion transmembrane transporter activity
N3115_09220	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
N3115_09260	COG0512	Glutamine amidotransferase of anthranilate synthase
N3115_09270	COG0840	transmembrane signaling receptor activity
N3115_09290	COG1840	ABC-type Fe3 transport system, periplasmic component
N3115_09295	COG1178	ABC-type Fe3 transport system permease component
N3115_09310	COG4774	siderophore transport
N3115_09350	COG2183	response to ionizing radiation
N3115_09360	COG0251	oxidation-reduction process
N3115_09375	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
N3115_09385	COG0586	Pfam SNARE associated Golgi protein
N3115_09390	COG0335	large ribosomal subunit rRNA binding
N3115_09395	COG0336	Belongs to the RNA methyltransferase TrmD family
N3115_09405	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
N3115_09410	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
N3115_09415	COG0356	it plays a direct role in the translocation of protons across the membrane
N3115_09425	COG4773	Receptor
N3115_09435	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
N3115_09445	COG0157	Belongs to the NadC ModD family
N3115_09460	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
N3115_09470	COG0083	homoserine kinase activity
N3115_09480	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
N3115_09485	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
N3115_09490	COG0779	Required for maturation of 30S ribosomal subunits
N3115_09495	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
N3115_09495	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
N3115_09500	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
N3115_09505	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
N3115_09510	COG0539	negative regulation of cytoplasmic translation
N3115_09510	COG1185	polyribonucleotide nucleotidyltransferase activity
N3115_09515	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
N3115_09520	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
N3115_09525	COG0072	phenylalanine-tRNA ligase activity
N3115_09525	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
N3115_09530	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
N3115_09535	COG0537	adenosine 5'-monophosphoramidase activity
N3115_09540	COG0825	malonyl-CoA metabolic process
N3115_09545	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
N3115_09550	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
N3115_09560	COG0602	queuosine metabolic process
N3115_09570	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
N3115_09580	COG1385	rRNA (uridine-N3-)-methyltransferase activity
N3115_09590	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
N3115_09600	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
N3115_09605	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
N3115_09610	COG1074	ATP-dependent DNA helicase activity
N3115_09620	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
N3115_09630	COG3328	transposase activity
N3115_09675	COG3278	Belongs to the heme-copper respiratory oxidase family
N3115_09680	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
N3115_09685	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
N3115_09690	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
N3115_09705	COG1242	4 iron, 4 sulfur cluster binding
N3115_09710	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
N3115_09715	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
N3115_09720	COG0492	ferredoxin-NADP+ reductase activity
N3115_09725	COG3118	belongs to the thioredoxin family
N3115_09730	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
N3115_09755	COG0642	Histidine kinase
N3115_09760	COG0745	RESPONSE REGULATOR receiver
N3115_09770	COG0129	dihydroxy-acid dehydratase activity
N3115_09800	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
N3115_09815	COG0585	pseudouridine synthase activity
N3115_09830	COG0793	Belongs to the peptidase S41A family
N3115_09835	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
N3115_09840	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
N3115_09845	COG0047	phosphoribosylformylglycinamidine synthase activity
N3115_09855	COG0204	Acyl-transferase
N3115_09860	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
N3115_09865	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
N3115_09870	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
N3115_09875	COG0018	arginyl-trna synthetase
N3115_09885	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
N3115_09895	COG0126	phosphoglycerate kinase activity
N3115_09900	COG0149	triose-phosphate isomerase activity
N3115_09905	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
N3115_09910	COG0019	diaminopimelate decarboxylase activity
N3115_09915	COG1605	Chorismate mutase
N3115_09915	COG0077	Prephenate dehydratase
N3115_09920	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
N3115_09925	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
N3115_09935	COG0424	maF-like protein
N3115_09950	COG0791	NLP P60 protein
N3115_09965	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
N3115_09970	COG1012	belongs to the aldehyde dehydrogenase family
N3115_09980	COG1704	LemA family
N3115_09995	COG0546	phosphoglycolate phosphatase activity
N3115_10000	COG0783	Belongs to the Dps family
N3115_10005	COG2814	Major facilitator Superfamily
N3115_10025	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
N3115_10045	COG1595	DNA-templated transcription, initiation
N3115_10055	COG2081	HI0933 family
N3115_10070	COG1959	2 iron, 2 sulfur cluster binding
N3115_10085	COG0175	sulfate reduction
N3115_10090	COG0175	sulfate reduction
N3115_10095	COG2895	sulfate adenylyltransferase (ATP) activity
N3115_10110	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
N3115_10145	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
N3115_10165	COG0189	ligase activity
N3115_10180	COG2199	diguanylate cyclase activity
N3115_10180	COG3287	FIST C domain
N3115_10180	COG2200	EAL domain
N3115_10185	COG0688	phosphatidylethanolamine metabolic process
N3115_10195	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
N3115_10200	COG0443	Heat shock 70 kDa protein
N3115_10205	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
N3115_10220	COG0101	tRNA pseudouridine synthase activity
N3115_10235	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
N3115_10240	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
N3115_10245	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
N3115_10260	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
N3115_10265	COG0494	nUDIX hydrolase
N3115_10295	COG1484	DNA-dependent DNA replication
N3115_10340	COG0445	tRNA wobble uridine modification
N3115_10360	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
N3115_10365	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
N3115_10370	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
N3115_10380	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
N3115_10390	COG1252	NADH dehydrogenase
N3115_10395	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
N3115_10405	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
N3115_10420	COG2814	Major facilitator Superfamily
N3115_10425	COG0659	secondary active sulfate transmembrane transporter activity
N3115_10445	COG1222	aaa ATPase
N3115_10455	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
N3115_10460	COG0812	UDP-N-acetylmuramate dehydrogenase activity
N3115_10475	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
N3115_10490	COG0148	phosphopyruvate hydratase activity
N3115_10495	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
N3115_10505	COG1086	Polysaccharide biosynthesis protein
N3115_10510	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
N3115_10515	COG1083	cytidylyl-transferase
N3115_10520	COG2089	acid synthase
N3115_10540	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
N3115_10560	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
N3115_10570	COG0348	domain, Protein
N3115_10575	COG0504	CTP synthase activity
N3115_10580	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
N3115_10600	COG0587	DNA-directed DNA polymerase activity
N3115_10605	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
N3115_10620	COG0315	cyclic pyranopterin monophosphate synthase activity
N3115_10625	COG0828	Belongs to the bacterial ribosomal protein bS21 family
N3115_10655	COG0670	Belongs to the BI1 family
N3115_10660	COG0352	thiamine-phosphate diphosphorylase activity
N3115_10670	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
N3115_10675	COG0233	cytoplasmic translational termination
N3115_10680	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
N3115_10700	COG3022	response to hydroperoxide
N3115_10715	COG1408	metallophosphoesterase
N3115_10720	COG0071	Belongs to the small heat shock protein (HSP20) family
N3115_10725	COG2703	oxygen carrier activity
N3115_10730	COG0840	transmembrane signaling receptor activity
N3115_10745	COG4208	sulfate ABC transporter
N3115_10750	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
N3115_10760	COG2200	EAL domain
N3115_10760	COG3287	FIST C domain
N3115_10760	COG2199	diguanylate cyclase activity
N3115_10780	COG1217	gtp-binding protein TYPA
N3115_10785	COG2391	methyltransferase activity
N3115_10790	COG0425	Belongs to the sulfur carrier protein TusA family
N3115_10825	COG3706	GGDEF domain
N3115_10870	COG0745	RESPONSE REGULATOR receiver
N3115_10875	COG0642	Histidine kinase
N3115_10880	COG2226	methyltransferase
N3115_10890	COG3437	response regulator, receiver
N3115_10890	COG0784	Response regulator, receiver
N3115_10895	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
N3115_10910	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
N3115_10915	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
N3115_10920	COG1192	Involved in chromosome partitioning
N3115_10925	COG1475	DNA binding
N3115_10945	COG4584	PFAM Integrase catalytic
N3115_10950	COG1484	DNA-dependent DNA replication
N3115_10995	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
N3115_11020	COG1686	Belongs to the peptidase S11 family
N3115_11035	COG0840	transmembrane signaling receptor activity
N3115_11040	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
N3115_11050	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
N3115_11075	COG0745	RESPONSE REGULATOR receiver
N3115_11080	COG1639	'signal transduction protein
N3115_11090	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
N3115_11105	COG2151	metal-sulfur cluster biosynthetic enzyme
N3115_11125	COG1484	DNA-dependent DNA replication
N3115_11145	COG0326	Molecular chaperone. Has ATPase activity
N3115_11245	COG2226	methyltransferase
N3115_11255	COG0456	acetyltransferase