locus-tag	class	description
HOO41_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HOO41_00010	COG0592	DNA-directed DNA polymerase activity
HOO41_00015	COG0187	DNA topoisomerase II activity
HOO41_00020	COG0492	ferredoxin-NADP+ reductase activity
HOO41_00025	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HOO41_00045	COG0500	methyltransferase
HOO41_00050	COG3842	ATPase activity
HOO41_00105	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HOO41_00110	COG1538	Outer membrane efflux protein
HOO41_00115	COG0840	transmembrane signaling receptor activity
HOO41_00125	COG2081	HI0933 family
HOO41_00140	COG1959	2 iron, 2 sulfur cluster binding
HOO41_00155	COG0175	sulfate reduction
HOO41_00160	COG0175	sulfate reduction
HOO41_00165	COG2895	sulfate adenylyltransferase (ATP) activity
HOO41_00175	COG2814	Major facilitator Superfamily
HOO41_00180	COG0783	Belongs to the Dps family
HOO41_00185	COG0546	phosphoglycolate phosphatase activity
HOO41_00195	COG1012	belongs to the aldehyde dehydrogenase family
HOO41_00200	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HOO41_00215	COG3022	response to hydroperoxide
HOO41_00235	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HOO41_00240	COG0233	cytoplasmic translational termination
HOO41_00245	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HOO41_00255	COG0352	thiamine-phosphate diphosphorylase activity
HOO41_00260	COG0670	Belongs to the BI1 family
HOO41_00290	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HOO41_00310	COG1459	type II secretion system
HOO41_00315	COG0598	Magnesium transport protein CorA
HOO41_00330	COG1178	ABC-type Fe3 transport system permease component
HOO41_00335	COG1840	ABC-type Fe3 transport system, periplasmic component
HOO41_00495	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HOO41_00500	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HOO41_00505	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HOO41_00510	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HOO41_00515	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HOO41_00520	COG1077	Cell shape determining protein MreB Mrl
HOO41_00535	COG0445	tRNA wobble uridine modification
HOO41_00605	COG2801	Transposase and inactivated derivatives
HOO41_00615	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HOO41_00645	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
HOO41_00650	COG1028	Short-chain dehydrogenase reductase Sdr
HOO41_00655	COG0659	secondary active sulfate transmembrane transporter activity
HOO41_00670	COG1222	aaa ATPase
HOO41_00680	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
HOO41_00685	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HOO41_00695	COG3077	Addiction module antitoxin, RelB DinJ family
HOO41_00720	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HOO41_00725	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HOO41_00735	COG1086	Polysaccharide biosynthesis protein
HOO41_00740	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HOO41_00745	COG1083	cytidylyl-transferase
HOO41_00755	COG2089	acid synthase
HOO41_00770	COG1028	Short-chain dehydrogenase reductase Sdr
HOO41_00775	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HOO41_00780	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HOO41_00790	COG1216	Glycosyl transferase, family 2
HOO41_00795	COG1216	Glycosyl transferase, family 2
HOO41_00805	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HOO41_00810	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
HOO41_00820	COG1215	transferase activity, transferring glycosyl groups
HOO41_00825	COG3475	LICD family
HOO41_00835	COG1442	glycosyl transferase family 8
HOO41_00835	COG1216	Glycosyl transferase, family 2
HOO41_00870	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HOO41_00910	COG1083	cytidylyl-transferase
HOO41_00915	COG1028	Short-chain dehydrogenase reductase Sdr
HOO41_00945	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HOO41_00960	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HOO41_00970	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HOO41_00975	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HOO41_00980	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HOO41_01005	COG1420	regulation of RNA biosynthetic process
HOO41_01010	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HOO41_01015	COG0443	Heat shock 70 kDa protein
HOO41_01035	COG2121	Domain of unknown function (DUF374)
HOO41_01040	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HOO41_01050	COG0195	Participates in both transcription termination and antitermination
HOO41_01055	COG0215	cysteine-tRNA ligase activity
HOO41_01060	COG1393	Belongs to the ArsC family
HOO41_01065	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HOO41_01070	COG0343	queuine tRNA-ribosyltransferase activity
HOO41_01100	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HOO41_01105	COG0557	exoribonuclease II activity
HOO41_01115	COG1466	dna polymerase III delta subunit
HOO41_01120	COG0360	Binds together with S18 to 16S ribosomal RNA
HOO41_01125	COG0629	single-stranded DNA binding
HOO41_01130	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HOO41_01140	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HOO41_01155	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HOO41_01165	COG0157	Belongs to the NadC ModD family
HOO41_01180	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
HOO41_01190	COG0083	homoserine kinase activity
HOO41_01200	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HOO41_01205	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HOO41_01210	COG0779	Required for maturation of 30S ribosomal subunits
HOO41_01215	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HOO41_01215	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HOO41_01220	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HOO41_01225	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HOO41_01230	COG1185	polyribonucleotide nucleotidyltransferase activity
HOO41_01230	COG0539	negative regulation of cytoplasmic translation
HOO41_01235	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HOO41_01240	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HOO41_01245	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HOO41_01245	COG0072	phenylalanine-tRNA ligase activity
HOO41_01250	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HOO41_01255	COG0537	adenosine 5'-monophosphoramidase activity
HOO41_01260	COG0825	malonyl-CoA metabolic process
HOO41_01265	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HOO41_01270	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HOO41_01280	COG0602	queuosine metabolic process
HOO41_01290	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HOO41_01310	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HOO41_01320	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HOO41_01325	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HOO41_01330	COG1074	ATP-dependent DNA helicase activity
HOO41_01340	COG0356	it plays a direct role in the translocation of protons across the membrane
HOO41_01345	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HOO41_01350	COG0191	fructose-bisphosphate aldolase activity
HOO41_01360	COG0745	RESPONSE REGULATOR receiver
HOO41_01365	COG0642	Histidine kinase
HOO41_01390	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HOO41_01400	COG2199	diguanylate cyclase activity
HOO41_01400	COG3287	FIST C domain
HOO41_01400	COG2200	EAL domain
HOO41_01420	COG3043	anaerobic respiration
HOO41_01425	COG0348	domain, Protein
HOO41_01430	COG0437	4 iron, 4 sulfur cluster binding
HOO41_01435	COG0243	molybdopterin cofactor binding
HOO41_01450	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HOO41_01455	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HOO41_01460	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HOO41_01470	COG2404	hydrolase activity, acting on ester bonds
HOO41_01490	COG0840	transmembrane signaling receptor activity
HOO41_01495	COG0840	transmembrane signaling receptor activity
HOO41_01500	COG3852	Histidine kinase
HOO41_01525	COG2030	dehydratase
HOO41_01555	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HOO41_01560	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HOO41_01565	COG0542	response to heat
HOO41_01600	COG0148	phosphopyruvate hydratase activity
HOO41_01615	COG2814	Major facilitator Superfamily
HOO41_01625	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HOO41_01630	COG0049	tRNA binding
HOO41_01635	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HOO41_01640	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HOO41_01645	COG0497	DNA recombination
HOO41_01650	COG0840	transmembrane signaling receptor activity
HOO41_01655	COG0826	peptidase U32
HOO41_01665	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HOO41_01675	COG0752	glycyl-tRNA synthetase alpha subunit
HOO41_01680	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HOO41_01690	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HOO41_01690	COG1519	Transferase
HOO41_01695	COG0564	pseudouridine synthase activity
HOO41_01700	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HOO41_01705	COG0228	four-way junction DNA binding
HOO41_01710	COG1837	Belongs to the UPF0109 family
HOO41_01715	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HOO41_01735	COG0745	RESPONSE REGULATOR receiver
HOO41_01745	COG4786	Flagellar basal body rod
HOO41_01750	COG1815	bacterial-type flagellum-dependent cell motility
HOO41_01755	COG1766	The M ring may be actively involved in energy transduction
HOO41_01760	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HOO41_01770	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HOO41_01780	COG1749	Flagellar hook protein flgE
HOO41_01785	COG1749	Flagellar hook protein flgE
HOO41_01810	COG3951	Flagellar rod assembly protein muramidase FlgJ
HOO41_01825	COG1419	protein localization to endoplasmic reticulum
HOO41_01830	COG0455	bacterial-type flagellum organization
HOO41_01860	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HOO41_01870	COG1157	protein secretion by the type III secretion system
HOO41_01880	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HOO41_01890	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HOO41_01915	COG0840	transmembrane signaling receptor activity
HOO41_01920	COG0840	transmembrane signaling receptor activity
HOO41_01925	COG0840	transmembrane signaling receptor activity
HOO41_01935	COG5001	Diguanylate cyclase
HOO41_01935	COG3300	MHYT domain
HOO41_01940	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HOO41_01950	COG0336	Belongs to the RNA methyltransferase TrmD family
HOO41_01955	COG0335	large ribosomal subunit rRNA binding
HOO41_01960	COG0586	Pfam SNARE associated Golgi protein
HOO41_01965	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HOO41_01990	COG0251	oxidation-reduction process
HOO41_01995	COG3610	response to peptide
HOO41_02000	COG2966	Psort location CytoplasmicMembrane, score
HOO41_02015	COG0811	peptide transport
HOO41_02045	COG1971	Probably functions as a manganese efflux pump
HOO41_02070	COG0628	permease
HOO41_02080	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HOO41_02085	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
HOO41_02100	COG4773	Receptor
HOO41_02105	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HOO41_02110	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HOO41_02120	COG0142	geranyltranstransferase activity
HOO41_02125	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HOO41_02130	COG0442	prolyl-tRNA aminoacylation
HOO41_02135	COG0668	transmembrane transport
HOO41_02145	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HOO41_02150	COG1862	Preprotein translocase
HOO41_02155	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HOO41_02160	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HOO41_02175	COG1360	Flagellar Motor Protein
HOO41_02180	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HOO41_02190	COG0495	leucyl-tRNA aminoacylation
HOO41_02200	COG0285	dihydrofolate synthase activity
HOO41_02225	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HOO41_02235	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HOO41_02245	COG1605	Chorismate mutase
HOO41_02245	COG0077	Prephenate dehydratase
HOO41_02250	COG0454	-acetyltransferase
HOO41_02280	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HOO41_02285	COG0444	Belongs to the ABC transporter superfamily
HOO41_02290	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HOO41_02295	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HOO41_02325	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HOO41_02330	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HOO41_02345	COG0250	Participates in transcription elongation, termination and antitermination
HOO41_02350	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HOO41_02355	COG0081	regulation of translation
HOO41_02360	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HOO41_02365	COG0222	ribosome binding
HOO41_02370	COG0085	RNA polymerase activity
HOO41_02375	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HOO41_02395	COG0386	Belongs to the glutathione peroxidase family
HOO41_02400	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
HOO41_02405	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
HOO41_02425	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
HOO41_02440	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HOO41_02445	COG0298	carbon dioxide binding
HOO41_02460	COG0309	Hydrogenase expression formation protein (HypE)
HOO41_02475	COG0310	cobalt ion transport
HOO41_02495	COG2877	3-deoxy-8-phosphooctulonate synthase activity
HOO41_02505	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HOO41_02515	COG1295	ribonuclease BN
HOO41_02520	COG0277	FAD linked oxidase domain protein
HOO41_02530	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HOO41_02535	COG2226	methyltransferase
HOO41_02540	COG0196	riboflavin kinase activity
HOO41_02555	COG1739	Uncharacterized protein family UPF0029
HOO41_02580	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HOO41_02640	COG1216	Glycosyl transferase, family 2
HOO41_02645	COG0438	transferase activity, transferring glycosyl groups
HOO41_02660	COG0463	Glycosyl transferase, family 2
HOO41_02665	COG0859	PFAM glycosyl transferase family 9
HOO41_02680	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
HOO41_02685	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
HOO41_02685	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HOO41_02695	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HOO41_02705	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HOO41_02715	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HOO41_02730	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HOO41_02740	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HOO41_02790	COG0577	efflux transmembrane transporter activity
HOO41_02790	COG1136	(ABC) transporter
HOO41_02805	COG2353	YceI-like domain
HOO41_02815	COG1408	metallophosphoesterase
HOO41_02830	COG1121	(ABC) transporter
HOO41_02835	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HOO41_02840	COG2996	Protein conserved in bacteria
HOO41_02845	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
HOO41_02865	COG0525	valine-tRNA ligase activity
HOO41_02895	COG2814	Major facilitator Superfamily
HOO41_02900	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HOO41_02920	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HOO41_02930	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HOO41_02935	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HOO41_02945	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HOO41_02965	COG0439	Biotin carboxylase
HOO41_02975	COG2166	iron-sulfur cluster assembly
HOO41_02980	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HOO41_02990	COG0396	ATPase activity
HOO41_02995	COG0719	Fe-S assembly protein
HOO41_03010	COG3706	GGDEF domain
HOO41_03015	COG0165	Argininosuccinate lyase
HOO41_03020	COG0556	nucleotide-excision repair
HOO41_03030	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HOO41_03035	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HOO41_03040	COG0784	Response regulator, receiver
HOO41_03040	COG0835	chemotaxis
HOO41_03050	COG0582	viral genome integration into host DNA
HOO41_03200	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HOO41_03205	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HOO41_03210	COG0585	pseudouridine synthase activity
HOO41_03220	COG0840	transmembrane signaling receptor activity
HOO41_03225	COG0632	four-way junction helicase activity
HOO41_03230	COG1181	Belongs to the D-alanine--D-alanine ligase family
HOO41_03240	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HOO41_03265	COG0284	orotidine-5'-phosphate decarboxylase activity
HOO41_03270	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HOO41_03275	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HOO41_03280	COG0174	glutamine synthetase
HOO41_03290	COG0314	molybdopterin synthase activity
HOO41_03300	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
HOO41_03305	COG1968	undecaprenyl-diphosphatase activity
HOO41_03315	COG0772	Belongs to the SEDS family
HOO41_03320	COG0768	penicillin binding
HOO41_03325	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HOO41_03330	COG1858	cytochrome C peroxidase
HOO41_03360	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HOO41_03375	COG1116	anion transmembrane transporter activity
HOO41_03380	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HOO41_03395	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HOO41_03405	COG2204	response regulator
HOO41_03415	COG3706	GGDEF domain
HOO41_03425	COG0745	RESPONSE REGULATOR receiver
HOO41_03430	COG0642	Histidine kinase
HOO41_03435	COG2081	HI0933 family
HOO41_03440	COG0840	transmembrane signaling receptor activity
HOO41_03450	COG3920	Histidine kinase
HOO41_03455	COG5002	protein histidine kinase activity
HOO41_03460	COG1692	metallophosphoesterase
HOO41_03480	COG1570	exodeoxyribonuclease VII activity
HOO41_03485	COG0835	chemotaxis
HOO41_03495	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
HOO41_03500	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HOO41_03510	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HOO41_03515	COG0459	protein refolding
HOO41_03520	COG1686	Belongs to the peptidase S11 family
HOO41_03535	COG0848	biopolymer transport protein
HOO41_03540	COG0811	peptide transport
HOO41_03555	COG0577	efflux transmembrane transporter activity
HOO41_03555	COG1136	(ABC) transporter
HOO41_03560	COG0577	efflux transmembrane transporter activity
HOO41_03560	COG1136	(ABC) transporter
HOO41_03565	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HOO41_03570	COG0542	response to heat
HOO41_03575	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HOO41_03585	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HOO41_03590	COG0706	membrane insertase activity
HOO41_03600	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HOO41_03620	COG3706	GGDEF domain
HOO41_03630	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HOO41_03635	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HOO41_03640	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HOO41_03650	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HOO41_03655	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HOO41_03670	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HOO41_03675	COG0305	Participates in initiation and elongation during chromosome replication
HOO41_03690	COG0673	inositol 2-dehydrogenase activity
HOO41_03695	COG4771	TonB-dependent receptor
HOO41_03715	COG2819	hydrolase of the alpha beta superfamily
HOO41_03720	COG0500	methyltransferase
HOO41_03740	COG1966	Carbon starvation protein
HOO41_03745	COG0563	adenylate kinase activity
HOO41_03750	COG0563	adenylate kinase activity
HOO41_03760	COG3706	GGDEF domain
HOO41_03765	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HOO41_03770	COG1979	alcohol dehydrogenase
HOO41_03785	COG0840	transmembrane signaling receptor activity
HOO41_03790	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HOO41_03795	COG0322	excinuclease ABC activity
HOO41_03800	COG0840	transmembrane signaling receptor activity
HOO41_03825	COG0745	RESPONSE REGULATOR receiver
HOO41_03850	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HOO41_03860	COG0784	Response regulator, receiver
HOO41_03860	COG3437	response regulator, receiver
HOO41_03865	COG1338	Plays a role in the flagellum-specific transport system
HOO41_03870	COG0768	penicillin binding
HOO41_03890	COG2884	Cell division ATP-binding protein ftsE
HOO41_03895	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HOO41_03905	COG0564	pseudouridine synthase activity
HOO41_03910	COG0772	Belongs to the SEDS family
HOO41_03920	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HOO41_03925	COG3123	guanosine phosphorylase activity
HOO41_04005	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HOO41_04010	COG0475	glutathione-regulated potassium exporter activity
HOO41_04010	COG0569	domain protein
HOO41_04015	COG0210	DNA helicase
HOO41_04020	COG0709	Synthesizes selenophosphate from selenide and ATP
HOO41_04025	COG1305	Transglutaminase-like
HOO41_04045	COG2204	response regulator
HOO41_04080	COG0243	molybdopterin cofactor binding
HOO41_04080	COG3383	formate dehydrogenase (NAD+) activity
HOO41_04085	COG0437	4 iron, 4 sulfur cluster binding
HOO41_04095	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HOO41_04100	COG1104	cysteine desulfurase activity
HOO41_04105	COG0303	'Molybdopterin
HOO41_04115	COG2814	Major facilitator Superfamily
HOO41_04160	COG0330	HflC and HflK could
HOO41_04175	COG2354	Protein conserved in bacteria
HOO41_04180	COG0726	polysaccharide deacetylase
HOO41_04185	COG2081	HI0933 family
HOO41_04190	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
HOO41_04200	COG4804	nuclease activity
HOO41_04210	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HOO41_04235	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HOO41_04240	COG2171	N-acyltransferase activity
HOO41_04245	COG1944	ATP diphosphatase activity
HOO41_04250	COG2169	Transcriptional regulator
HOO41_04250	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HOO41_04255	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HOO41_04300	COG0628	permease
HOO41_04305	COG2255	four-way junction helicase activity
HOO41_04310	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HOO41_04315	COG0159	tryptophan synthase activity
HOO41_04320	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
HOO41_04330	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
HOO41_04345	COG0137	argininosuccinate synthase activity
HOO41_04350	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HOO41_04355	COG0742	ribosomal rna small subunit methyltransferase
HOO41_04360	COG1418	mRNA catabolic process
HOO41_04375	COG0552	protein localization to endoplasmic reticulum
HOO41_04395	COG1733	regulation of RNA biosynthetic process
HOO41_04400	COG2249	NAD(P)H dehydrogenase (quinone) activity
HOO41_04405	COG1902	pentaerythritol trinitrate reductase activity
HOO41_04420	COG0488	(ABC) transporter
HOO41_04425	COG1607	acyl-coa hydrolase
HOO41_04430	COG0840	transmembrane signaling receptor activity
HOO41_04440	COG0484	heat shock protein binding
HOO41_04460	COG4974	Belongs to the 'phage' integrase family
HOO41_04515	COG0300	oxidoreductase activity
HOO41_04525	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HOO41_04530	COG0802	atpase or kinase
HOO41_04535	COG1137	ATPase activity
HOO41_04560	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
HOO41_04570	COG2201	protein-glutamate methylesterase activity
HOO41_04585	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HOO41_04630	COG2076	Multidrug Resistance protein
HOO41_04635	COG0642	Histidine kinase
HOO41_04650	COG3258	Cytochrome c
HOO41_04660	COG1049	propionate catabolic process, 2-methylcitrate cycle
HOO41_04665	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
HOO41_04670	COG2363	Small membrane protein
HOO41_04675	COG1666	GTP binding
HOO41_04715	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
HOO41_04730	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HOO41_04730	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HOO41_04740	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
HOO41_04765	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HOO41_04775	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
HOO41_04780	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HOO41_04785	COG0287	Prephenate dehydrogenase
HOO41_04800	COG1921	L-seryl-tRNASec selenium transferase activity
HOO41_04810	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HOO41_04815	COG0135	phosphoribosylanthranilate isomerase activity
HOO41_04820	COG2176	DNA-directed DNA polymerase activity
HOO41_04830	COG1013	pyruvate-flavodoxin oxidoreductase activity
HOO41_04835	COG0674	pyruvate-flavodoxin oxidoreductase activity
HOO41_04835	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HOO41_04845	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
HOO41_04850	COG0727	PFAM Uncharacterised protein family (UPF0153)
HOO41_04860	COG0134	indole-3-glycerol-phosphate synthase activity
HOO41_04865	COG0583	DNA-binding transcription factor activity
HOO41_04870	COG1942	4-Oxalocrotonate Tautomerase
HOO41_04875	COG2199	diguanylate cyclase activity
HOO41_04885	COG0739	heme binding
HOO41_04890	COG1610	YqeY-like protein
HOO41_04895	COG0488	(ABC) transporter
HOO41_04900	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HOO41_04920	COG0667	Aldo Keto reductase
HOO41_04925	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HOO41_04930	COG0805	protein transport
HOO41_04935	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HOO41_04945	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
HOO41_04960	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HOO41_04965	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HOO41_04970	COG1663	tetraacyldisaccharide 4'-kinase activity
HOO41_04975	COG0861	Integral membrane protein TerC family
HOO41_04980	COG0789	Transcriptional regulator
HOO41_04985	COG0484	heat shock protein binding
HOO41_04990	COG4191	Histidine kinase
HOO41_05000	COG2201	protein-glutamate methylesterase activity
HOO41_05020	COG0776	regulation of translation
HOO41_05030	COG0275	rRNA processing
HOO41_05055	COG0039	L-malate dehydrogenase activity
HOO41_05065	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HOO41_05080	COG1193	negative regulation of DNA recombination
HOO41_05085	COG1253	flavin adenine dinucleotide binding
HOO41_05095	COG1119	ATPase activity
HOO41_05105	COG2258	MOSC domain
HOO41_05110	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HOO41_05120	COG3135	benzoate transporter
HOO41_05130	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HOO41_05135	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HOO41_05140	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HOO41_05140	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HOO41_05155	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HOO41_05170	COG0527	aspartate kinase activity
HOO41_05175	COG0494	nUDIX hydrolase
HOO41_05180	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HOO41_05185	COG2890	protein-(glutamine-N5) methyltransferase activity
HOO41_05190	COG0339	signal peptide processing
HOO41_05205	COG0824	Thioesterase
HOO41_05210	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HOO41_05215	COG0501	Belongs to the peptidase M48B family
HOO41_05225	COG2321	neutral zinc metallopeptidase
HOO41_05245	COG0037	tRNA processing
HOO41_05280	COG0028	Belongs to the TPP enzyme family
HOO41_05285	COG0440	acetolactate synthase activity
HOO41_05290	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HOO41_05295	COG1196	nuclear chromosome segregation
HOO41_05295	COG1674	ftsk spoiiie
HOO41_05300	COG1028	Short-chain dehydrogenase reductase Sdr
HOO41_05310	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HOO41_05315	COG1160	GTP binding
HOO41_05320	COG0659	secondary active sulfate transmembrane transporter activity
HOO41_05340	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
HOO41_05350	COG1185	polyribonucleotide nucleotidyltransferase activity
HOO41_05355	COG0745	RESPONSE REGULATOR receiver
HOO41_05360	COG2198	Histidine kinase
HOO41_05360	COG0643	Histidine kinase
HOO41_05365	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HOO41_05370	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
HOO41_05375	COG2201	protein-glutamate methylesterase activity
HOO41_05380	COG0582	viral genome integration into host DNA
HOO41_05385	COG0484	heat shock protein binding
HOO41_05410	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HOO41_05420	COG3706	GGDEF domain
HOO41_05420	COG4251	negative regulation of phosphorylation
HOO41_05420	COG5001	Diguanylate cyclase
HOO41_05420	COG2203	Gaf domain
HOO41_05425	COG0500	methyltransferase
HOO41_05435	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HOO41_05435	COG1333	cytochrome c biogenesis protein
HOO41_05440	COG2195	Cleaves the N-terminal amino acid of tripeptides
HOO41_05455	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
HOO41_05460	COG0653	protein targeting
HOO41_05470	COG0521	Mo-molybdopterin cofactor biosynthetic process
HOO41_05480	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HOO41_05485	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HOO41_05495	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HOO41_05525	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HOO41_05530	COG4206	TonB-dependent receptor
HOO41_05550	COG0546	phosphoglycolate phosphatase activity
HOO41_05560	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
HOO41_05585	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
HOO41_05595	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HOO41_05595	COG4191	Histidine kinase
HOO41_05605	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HOO41_05605	COG0475	glutathione-regulated potassium exporter activity
HOO41_05645	COG1451	nucleotide metabolic process
HOO41_05655	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HOO41_05660	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HOO41_05660	COG0519	Catalyzes the synthesis of GMP from XMP
HOO41_05695	COG0596	Alpha beta hydrolase
HOO41_05710	COG5001	Diguanylate cyclase
HOO41_05710	COG5002	protein histidine kinase activity
HOO41_05715	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HOO41_05720	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HOO41_05725	COG0415	Belongs to the DNA photolyase family
HOO41_05730	COG1090	epimerase
HOO41_05740	COG3040	lipid binding
HOO41_05745	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HOO41_05755	COG3046	protein related to deoxyribodipyrimidine photolyase
HOO41_05770	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HOO41_05780	COG2200	EAL domain
HOO41_05785	COG3279	Response regulator of the LytR AlgR family
HOO41_05790	COG3275	phosphorelay sensor kinase activity
HOO41_05795	COG1233	COG1233 Phytoene dehydrogenase and related
HOO41_05815	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HOO41_05815	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HOO41_05825	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HOO41_05835	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HOO41_05840	COG0735	belongs to the Fur family
HOO41_05850	COG0728	peptidoglycan biosynthetic process
HOO41_05855	COG1132	(ABC) transporter
HOO41_05860	COG0167	dihydroorotate dehydrogenase activity
HOO41_05865	COG0612	Peptidase, M16
HOO41_05870	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HOO41_05875	COG1028	Short-chain dehydrogenase reductase Sdr
HOO41_05880	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HOO41_05885	COG0750	zinc metalloprotease
HOO41_05890	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HOO41_05900	COG0840	transmembrane signaling receptor activity
HOO41_05910	COG0642	Histidine kinase
HOO41_05915	COG0745	RESPONSE REGULATOR receiver
HOO41_05925	COG1132	(ABC) transporter
HOO41_05930	COG0217	transcriptional regulatory protein
HOO41_05950	COG1611	Belongs to the LOG family
HOO41_05955	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HOO41_05975	COG0351	phosphomethylpyrimidine kinase
HOO41_05975	COG0352	thiamine-phosphate diphosphorylase activity
HOO41_05980	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HOO41_05995	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HOO41_06015	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HOO41_06020	COG1696	Membrane protein involved in D-alanine export
HOO41_06035	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HOO41_06105	COG5002	protein histidine kinase activity
HOO41_06110	COG0745	RESPONSE REGULATOR receiver
HOO41_06135	COG1114	Component of the transport system for branched-chain amino acids
HOO41_06140	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HOO41_06145	COG0788	formyltetrahydrofolate deformylase activity
HOO41_06150	COG1496	oxidoreductase activity
HOO41_06155	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HOO41_06160	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HOO41_06170	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HOO41_06185	COG0513	Belongs to the DEAD box helicase family
HOO41_06195	COG0754	glutathionylspermidine amidase activity
HOO41_06200	COG0840	transmembrane signaling receptor activity
HOO41_06210	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HOO41_06215	COG0516	GMP reductase activity
HOO41_06215	COG0517	IMP dehydrogenase activity
HOO41_06220	COG0154	amidase activity
HOO41_06225	COG0203	ribosomal protein L17
HOO41_06230	COG0202	RNA polymerase activity
HOO41_06235	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HOO41_06240	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HOO41_06245	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HOO41_06250	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HOO41_06265	COG0473	3-isopropylmalate dehydrogenase activity
HOO41_06270	COG0066	3-isopropylmalate dehydratase activity
HOO41_06275	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HOO41_06300	COG0357	Ribosomal RNA small subunit methyltransferase G
HOO41_06305	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HOO41_06310	COG0113	porphobilinogen synthase activity
HOO41_06350	COG0166	Belongs to the GPI family
HOO41_06365	COG1086	Polysaccharide biosynthesis protein
HOO41_06370	COG0367	asparagine synthase
HOO41_06395	COG1028	Short-chain dehydrogenase reductase Sdr
HOO41_06400	COG1083	cytidylyl-transferase
HOO41_06420	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HOO41_06435	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HOO41_06445	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HOO41_06540	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HOO41_06550	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HOO41_06560	COG2391	methyltransferase activity
HOO41_06565	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HOO41_06570	COG0849	cell division
HOO41_06580	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HOO41_06600	COG0446	pyridine nucleotide-disulphide oxidoreductase
HOO41_06605	COG0488	(ABC) transporter
HOO41_06610	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HOO41_06615	COG0095	Lipoate-protein ligase
HOO41_06620	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HOO41_06625	COG0508	dehydrogenase complex catalyzes the overall conversion of
HOO41_06630	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HOO41_06645	COG2217	Heavy metal translocating P-type atpase
HOO41_06650	COG0513	Belongs to the DEAD box helicase family
HOO41_06665	COG0840	transmembrane signaling receptor activity
HOO41_06670	COG0328	RNA-DNA hybrid ribonuclease activity
HOO41_06675	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HOO41_06685	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HOO41_06695	COG0456	acetyltransferase
HOO41_06700	COG0218	Necessary for normal cell division and for the maintenance of normal septation
HOO41_06715	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HOO41_06720	COG0131	Imidazoleglycerol-phosphate dehydratase
HOO41_06725	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HOO41_06735	COG0084	hydrolase, TatD family'
HOO41_06745	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
HOO41_06750	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
HOO41_06755	COG0359	binds to the 23S rRNA
HOO41_06765	COG0163	prenyltransferase activity
HOO41_06770	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HOO41_06775	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HOO41_06780	COG0124	histidyl-tRNA synthetase
HOO41_06785	COG1166	arginine decarboxylase activity
HOO41_06790	COG1045	serine acetyltransferase
HOO41_06795	COG0730	response to heat
HOO41_06825	COG1639	'signal transduction protein
HOO41_06830	COG0012	GTP binding
HOO41_06835	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HOO41_06840	COG2197	response regulator
HOO41_06875	COG3118	belongs to the thioredoxin family
HOO41_06880	COG0450	alkyl hydroperoxide reductase
HOO41_06885	COG0840	transmembrane signaling receptor activity
HOO41_06900	COG3706	GGDEF domain
HOO41_06925	COG2855	membrane
HOO41_06930	COG0583	DNA-binding transcription factor activity
HOO41_06935	COG0500	methyltransferase
HOO41_06940	COG2267	carboxylic ester hydrolase activity
HOO41_06955	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HOO41_06960	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HOO41_06965	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HOO41_06985	COG2986	histidine ammonia-lyase
HOO41_06990	COG1028	Short-chain dehydrogenase reductase Sdr
HOO41_07015	COG1131	(ABC) transporter
HOO41_07030	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HOO41_07050	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HOO41_07065	COG1032	radical SAM domain protein
HOO41_07075	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HOO41_07085	COG1573	uracil-dna glycosylase
HOO41_07090	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HOO41_07095	COG0024	Methionine aminopeptidase
HOO41_07100	COG0201	protein transport
HOO41_07105	COG0200	Binds to the 23S rRNA
HOO41_07110	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HOO41_07115	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HOO41_07120	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HOO41_07125	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HOO41_07130	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HOO41_07135	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HOO41_07140	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HOO41_07145	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HOO41_07150	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HOO41_07155	COG0255	Belongs to the universal ribosomal protein uL29 family
HOO41_07160	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HOO41_07165	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HOO41_07170	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HOO41_07175	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HOO41_07180	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HOO41_07185	COG0089	rRNA binding
HOO41_07190	COG0088	Forms part of the polypeptide exit tunnel
HOO41_07195	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HOO41_07200	COG0051	transcription antitermination factor activity, RNA binding
HOO41_07220	COG0708	Exodeoxyribonuclease III
HOO41_07225	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HOO41_07225	COG0301	tRNA thio-modification
HOO41_07245	COG0606	chelatase, subunit chli
HOO41_07250	COG0840	transmembrane signaling receptor activity
HOO41_07255	COG0840	transmembrane signaling receptor activity
HOO41_07265	COG0242	peptide deformylase activity
HOO41_07270	COG0740	serine-type endopeptidase activity
HOO41_07275	COG0544	peptidyl-prolyl cis-trans isomerase activity
HOO41_07280	COG2326	polyphosphate kinase activity
HOO41_07365	COG1337	RAMP superfamily
HOO41_07395	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HOO41_07400	COG1355	regulation of microtubule-based process
HOO41_07420	COG3256	nitric oxide reductase
HOO41_07430	COG2010	Cytochrome c
HOO41_07435	COG2010	Cytochrome c
HOO41_07440	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HOO41_07450	COG0535	radical SAM domain protein
HOO41_07460	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HOO41_07460	COG1648	precorrin-2 dehydrogenase activity
HOO41_07470	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HOO41_07470	COG1648	precorrin-2 dehydrogenase activity
HOO41_07475	COG1522	sequence-specific DNA binding
HOO41_07490	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HOO41_07495	COG1132	(ABC) transporter
HOO41_07505	COG1278	Cold shock
HOO41_07510	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HOO41_07545	COG2217	Heavy metal translocating P-type atpase
HOO41_07550	COG2199	diguanylate cyclase activity
HOO41_07550	COG2200	EAL domain
HOO41_07550	COG3287	FIST C domain
HOO41_07555	COG0194	GDP metabolic process
HOO41_07565	COG1136	(ABC) transporter
HOO41_07570	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HOO41_07575	COG0052	Belongs to the universal ribosomal protein uS2 family
HOO41_07580	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HOO41_07595	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HOO41_07600	COG0579	oxidoreductase
HOO41_07605	COG1546	Belongs to the CinA family
HOO41_07605	COG1058	Belongs to the CinA family
HOO41_07655	COG0745	RESPONSE REGULATOR receiver
HOO41_07665	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HOO41_07675	COG2176	DNA-directed DNA polymerase activity
HOO41_07705	COG2176	DNA-directed DNA polymerase activity
HOO41_07715	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HOO41_07720	COG0280	phosphate acetyltransferase
HOO41_07730	COG0616	signal peptide processing
HOO41_07735	COG0402	S-adenosylhomocysteine deaminase activity
HOO41_07740	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HOO41_07745	COG0006	proline dipeptidase activity
HOO41_07750	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HOO41_07755	COG0482	sulfurtransferase activity
HOO41_07760	COG0482	sulfurtransferase activity
HOO41_07770	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HOO41_07780	COG0481	GTPase activity
HOO41_07790	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HOO41_07795	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HOO41_07810	COG2095	MarC family integral membrane protein
HOO41_07815	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HOO41_07830	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HOO41_07835	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HOO41_07840	COG2264	protein methyltransferase activity
HOO41_07845	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HOO41_07855	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
HOO41_07865	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HOO41_07870	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HOO41_07875	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HOO41_07890	COG0840	transmembrane signaling receptor activity
HOO41_07930	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HOO41_07940	COG0133	tryptophan synthase activity
HOO41_07945	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HOO41_07950	COG1793	dna ligase
HOO41_07960	COG0626	cystathionine gamma-synthase activity
HOO41_07990	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HOO41_08030	COG0528	UMP kinase activity
HOO41_08035	COG1758	RNA polymerase activity
HOO41_08040	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HOO41_08045	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HOO41_08055	COG0860	N-Acetylmuramoyl-L-alanine amidase
HOO41_08070	COG0193	aminoacyl-tRNA hydrolase activity
HOO41_08075	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HOO41_08080	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HOO41_08085	COG0681	Belongs to the peptidase S26 family
HOO41_08090	COG0698	ribose 5-phosphate isomerase
HOO41_08130	COG3287	FIST C domain
HOO41_08130	COG2200	EAL domain
HOO41_08130	COG2199	diguanylate cyclase activity
HOO41_08135	COG0259	pyridoxamine-phosphate oxidase activity
HOO41_08140	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HOO41_08150	COG0513	Belongs to the DEAD box helicase family
HOO41_08170	COG0326	Molecular chaperone. Has ATPase activity
HOO41_08175	COG5001	Diguanylate cyclase
HOO41_08175	COG4251	negative regulation of phosphorylation
HOO41_08175	COG3706	GGDEF domain
HOO41_08175	COG2203	Gaf domain
HOO41_08195	COG0010	Belongs to the arginase family
HOO41_08200	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HOO41_08205	COG0581	inorganic phosphate transmembrane transporter activity
HOO41_08210	COG0573	inorganic phosphate transmembrane transporter activity
HOO41_08215	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HOO41_08225	COG4335	DNA alkylation repair
HOO41_08230	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HOO41_08240	COG2264	protein methyltransferase activity
HOO41_08265	COG2995	paraquat-inducible protein a
HOO41_08270	COG3008	intermembrane lipid transfer
HOO41_08275	COG0753	catalase activity
HOO41_08290	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HOO41_08295	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HOO41_08300	COG2207	Transcriptional regulator
HOO41_08305	COG0519	Catalyzes the synthesis of GMP from XMP
HOO41_08310	COG0668	transmembrane transport
HOO41_08315	COG1227	inorganic diphosphatase activity
HOO41_08320	COG3012	SEC-C Motif Domain Protein
HOO41_08330	COG1027	Aspartate ammonia-lyase
HOO41_08335	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HOO41_08340	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HOO41_08345	COG1047	Peptidyl-prolyl cis-trans
HOO41_08360	COG0823	Involved in the tonB-independent uptake of proteins
HOO41_08370	COG0848	biopolymer transport protein
HOO41_08375	COG0811	peptide transport
HOO41_08380	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HOO41_08385	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HOO41_08390	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HOO41_08395	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HOO41_08400	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HOO41_08405	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HOO41_08415	COG1475	DNA binding
HOO41_08420	COG1192	Involved in chromosome partitioning
HOO41_08435	COG0840	transmembrane signaling receptor activity
HOO41_08440	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HOO41_08445	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HOO41_08450	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HOO41_08455	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HOO41_08460	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HOO41_08465	COG0358	DNA primase activity
HOO41_08475	COG0571	ribonuclease III activity
HOO41_08480	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HOO41_08490	COG2326	polyphosphate kinase activity
HOO41_08505	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HOO41_08530	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HOO41_08540	COG0739	heme binding
HOO41_08540	COG0741	lytic transglycosylase activity
HOO41_08540	COG1196	nuclear chromosome segregation
HOO41_08560	COG2183	response to ionizing radiation
HOO41_08565	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HOO41_08570	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HOO41_08575	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HOO41_08580	COG0649	NAD binding
HOO41_08580	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HOO41_08585	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
HOO41_08595	COG0372	Belongs to the citrate synthase family
HOO41_08605	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HOO41_08610	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HOO41_08615	COG0839	Belongs to the complex I subunit 6 family
HOO41_08620	COG0713	ATP synthesis coupled electron transport
HOO41_08625	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HOO41_08635	COG1007	ATP synthesis coupled electron transport
HOO41_08645	COG1053	succinate dehydrogenase
HOO41_08650	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HOO41_08670	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HOO41_08675	COG0416	fatty acid biosynthetic process
HOO41_08680	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HOO41_08690	COG0105	UTP biosynthetic process
HOO41_08700	COG0450	alkyl hydroperoxide reductase
HOO41_08705	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HOO41_08710	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HOO41_08715	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HOO41_08720	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HOO41_08730	COG0181	hydroxymethylbilane synthase activity
HOO41_08735	COG1335	isochorismatase
HOO41_08775	COG3278	Belongs to the heme-copper respiratory oxidase family
HOO41_08780	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HOO41_08785	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HOO41_08790	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HOO41_08805	COG1242	4 iron, 4 sulfur cluster binding
HOO41_08810	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HOO41_08815	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HOO41_08820	COG0492	ferredoxin-NADP+ reductase activity
HOO41_08825	COG3118	belongs to the thioredoxin family
HOO41_08830	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HOO41_08855	COG0642	Histidine kinase
HOO41_08860	COG0745	RESPONSE REGULATOR receiver
HOO41_08870	COG0129	dihydroxy-acid dehydratase activity
HOO41_08900	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HOO41_08920	COG0585	pseudouridine synthase activity
HOO41_08935	COG0793	Belongs to the peptidase S41A family
HOO41_08940	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HOO41_08945	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HOO41_08950	COG0047	phosphoribosylformylglycinamidine synthase activity
HOO41_08960	COG0204	Acyl-transferase
HOO41_08965	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HOO41_08970	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HOO41_08975	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HOO41_08980	COG0018	arginyl-trna synthetase
HOO41_08990	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HOO41_09000	COG0126	phosphoglycerate kinase activity
HOO41_09005	COG0149	triose-phosphate isomerase activity
HOO41_09010	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HOO41_09015	COG0019	diaminopimelate decarboxylase activity
HOO41_09020	COG0077	Prephenate dehydratase
HOO41_09020	COG1605	Chorismate mutase
HOO41_09025	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HOO41_09030	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HOO41_09045	COG0424	maF-like protein
HOO41_09055	COG0791	NLP P60 protein
HOO41_09080	COG3118	belongs to the thioredoxin family
HOO41_09085	COG0189	ligase activity
HOO41_09100	COG2200	EAL domain
HOO41_09100	COG2199	diguanylate cyclase activity
HOO41_09100	COG3287	FIST C domain
HOO41_09105	COG0688	phosphatidylethanolamine metabolic process
HOO41_09115	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
HOO41_09125	COG0288	reversible hydration of carbon dioxide
HOO41_09130	COG0156	8-amino-7-oxononanoate synthase activity
HOO41_09135	COG0792	nuclease activity
HOO41_09155	COG5002	protein histidine kinase activity
HOO41_09160	COG0745	RESPONSE REGULATOR receiver
HOO41_09210	COG1987	bacterial-type flagellum assembly
HOO41_09220	COG1706	bacterial-type flagellum-dependent cell motility
HOO41_09240	COG0004	ammonium transporteR
HOO41_09245	COG0666	response to abiotic stimulus
HOO41_09250	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
HOO41_09260	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HOO41_09275	COG1742	UPF0060 membrane protein
HOO41_09290	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HOO41_09300	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HOO41_09315	COG0840	transmembrane signaling receptor activity
HOO41_09345	COG4735	regulation of single-species biofilm formation
HOO41_09400	COG2022	thiamine diphosphate biosynthetic process
HOO41_09405	COG1324	tolerance protein
HOO41_09410	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HOO41_09410	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HOO41_09420	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HOO41_09435	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HOO41_09440	COG0575	Belongs to the CDS family
HOO41_09465	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HOO41_09470	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HOO41_09475	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HOO41_09480	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HOO41_09490	COG0446	pyridine nucleotide-disulphide oxidoreductase
HOO41_09495	COG0746	molybdenum cofactor guanylyltransferase activity
HOO41_09500	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HOO41_09505	COG1393	Belongs to the ArsC family
HOO41_09510	COG2828	Protein conserved in bacteria
HOO41_09515	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HOO41_09525	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
HOO41_09535	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HOO41_09540	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
HOO41_09545	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HOO41_09550	COG0560	Phosphoserine phosphatase
HOO41_09560	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HOO41_09565	COG0786	glutamate:sodium symporter activity
HOO41_09580	COG0736	holo-[acyl-carrier-protein] synthase activity
HOO41_09585	COG0601	transmembrane transport
HOO41_09590	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HOO41_09600	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HOO41_09635	COG2824	Alkylphosphonate utilization operon protein PhnA
HOO41_09640	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HOO41_09650	COG0573	inorganic phosphate transmembrane transporter activity
HOO41_09655	COG0581	inorganic phosphate transmembrane transporter activity
HOO41_09660	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HOO41_09665	COG0704	Plays a role in the regulation of phosphate uptake
HOO41_09675	COG0745	RESPONSE REGULATOR receiver
HOO41_09680	COG5002	protein histidine kinase activity
HOO41_09685	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HOO41_09690	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HOO41_09700	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HOO41_09715	COG0546	phosphoglycolate phosphatase activity
HOO41_09735	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HOO41_09740	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HOO41_09745	COG1854	S-ribosylhomocysteine lyase activity
HOO41_09755	COG1686	Belongs to the peptidase S11 family
HOO41_09765	COG5002	protein histidine kinase activity
HOO41_09770	COG0646	methionine synthase
HOO41_09770	COG1410	methionine synthase
HOO41_09795	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HOO41_09795	COG0140	phosphoribosyl-ATP diphosphatase activity
HOO41_09810	COG0456	acetyltransferase
HOO41_09815	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HOO41_09820	COG1917	Cupin 2, conserved barrel domain protein
HOO41_09825	COG0489	protein tyrosine kinase activity
HOO41_09830	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
HOO41_09840	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HOO41_09840	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HOO41_09850	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HOO41_09855	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HOO41_09860	COG0268	Binds directly to 16S ribosomal RNA
HOO41_09865	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HOO41_09870	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HOO41_09875	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HOO41_09885	COG0540	Belongs to the ATCase OTCase family
HOO41_09890	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HOO41_09895	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HOO41_09900	COG0505	Belongs to the CarA family
HOO41_09910	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HOO41_09915	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
HOO41_09920	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HOO41_09950	COG4895	conserved protein (DUF2196)
HOO41_09955	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HOO41_09960	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HOO41_09965	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
HOO41_09970	COG0237	dephospho-CoA kinase activity
HOO41_09980	COG0348	domain, Protein
HOO41_09985	COG0504	CTP synthase activity
HOO41_09990	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HOO41_09990	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
HOO41_10005	COG0693	protein deglycase activity
HOO41_10010	COG0587	DNA-directed DNA polymerase activity
HOO41_10015	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
HOO41_10030	COG0315	cyclic pyranopterin monophosphate synthase activity
HOO41_10035	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HOO41_10040	COG0428	transporter
HOO41_10090	COG0109	protoheme IX farnesyltransferase activity
HOO41_10100	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HOO41_10105	COG0254	rRNA binding
HOO41_10110	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HOO41_10115	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HOO41_10125	COG0436	Aminotransferase
HOO41_10130	COG0460	homoserine dehydrogenase
HOO41_10135	COG0564	pseudouridine synthase activity
HOO41_10140	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HOO41_10145	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HOO41_10150	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HOO41_10155	COG3047	cAMP biosynthetic process
HOO41_10155	COG2885	chlorophyll binding
HOO41_10165	COG4206	TonB-dependent receptor
HOO41_10180	COG0745	RESPONSE REGULATOR receiver
HOO41_10200	COG0604	alcohol dehydrogenase
HOO41_10205	COG1733	regulation of RNA biosynthetic process
HOO41_10210	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HOO41_10215	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HOO41_10225	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HOO41_10225	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HOO41_10230	COG0511	ligase activity, forming carbon-carbon bonds
HOO41_10235	COG0439	Biotin carboxylase
HOO41_10240	COG0513	Belongs to the DEAD box helicase family
HOO41_10245	COG1278	Cold shock
HOO41_10260	COG0306	phosphate transporter
HOO41_10285	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
HOO41_10290	COG1981	membrane
HOO41_10295	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HOO41_10295	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
HOO41_10300	COG1187	pseudouridine synthase activity
HOO41_10305	COG0517	IMP dehydrogenase activity
HOO41_10305	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HOO41_10310	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HOO41_10315	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HOO41_10320	COG0107	imidazoleglycerol-phosphate synthase activity
HOO41_10335	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HOO41_10340	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HOO41_10345	COG0724	RNA recognition motif
HOO41_10350	COG0745	RESPONSE REGULATOR receiver
HOO41_10355	COG0642	Histidine kinase
HOO41_10375	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HOO41_10380	COG2353	YceI-like domain
HOO41_10385	COG0133	tryptophan synthase activity
HOO41_10400	COG1408	metallophosphoesterase
HOO41_10415	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HOO41_10420	COG4208	sulfate ABC transporter
HOO41_10425	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
HOO41_10435	COG2199	diguanylate cyclase activity
HOO41_10435	COG3287	FIST C domain
HOO41_10435	COG2200	EAL domain
HOO41_10450	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
HOO41_10455	COG1959	2 iron, 2 sulfur cluster binding
HOO41_10460	COG1217	gtp-binding protein TYPA
HOO41_10465	COG2391	methyltransferase activity
HOO41_10470	COG0425	Belongs to the sulfur carrier protein TusA family
HOO41_10485	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HOO41_10515	COG0745	RESPONSE REGULATOR receiver
HOO41_10520	COG0642	Histidine kinase
HOO41_10525	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
HOO41_10530	COG2860	membrane
HOO41_10545	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group