locus-tag	class	description
AFAEC_0001	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AFAEC_0002	COG0592	DNA-directed DNA polymerase activity
AFAEC_0003	COG0187	DNA topoisomerase II activity
AFAEC_0004	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
AFAEC_0007	COG1238	metal cluster binding
AFAEC_0009	COG0500	methyltransferase
AFAEC_0010	COG3842	ATPase activity
AFAEC_0016	COG2249	NAD(P)H dehydrogenase (quinone) activity
AFAEC_0017	COG1733	regulation of RNA biosynthetic process
AFAEC_0021	COG2895	sulfate adenylyltransferase (ATP) activity
AFAEC_0022	COG0175	sulfate reduction
AFAEC_0023	COG0175	sulfate reduction
AFAEC_0026	COG1959	2 iron, 2 sulfur cluster binding
AFAEC_0029	COG2081	HI0933 family
AFAEC_0030	COG0840	transmembrane signaling receptor activity
AFAEC_0032	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AFAEC_0033	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AFAEC_0035	COG0840	transmembrane signaling receptor activity
AFAEC_0036	COG2814	Major facilitator Superfamily
AFAEC_0037	COG0783	Belongs to the Dps family
AFAEC_0038	COG0546	phosphoglycolate phosphatase activity
AFAEC_0040	COG1012	belongs to the aldehyde dehydrogenase family
AFAEC_0041	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
AFAEC_0045	COG3012	SEC-C Motif Domain Protein
AFAEC_0047	COG3022	response to hydroperoxide
AFAEC_0049	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
AFAEC_0050	COG2814	Major facilitator Superfamily
AFAEC_0052	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
AFAEC_0053	COG0233	cytoplasmic translational termination
AFAEC_0055	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AFAEC_0057	COG0352	thiamine-phosphate diphosphorylase activity
AFAEC_0058	COG0670	Belongs to the BI1 family
AFAEC_0075	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
AFAEC_0078	COG1028	Short-chain dehydrogenase reductase Sdr
AFAEC_0081	COG2089	acid synthase
AFAEC_0082	COG3980	spore coat polysaccharide biosynthesis protein
AFAEC_0083	COG1083	cytidylyl-transferase
AFAEC_0084	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
AFAEC_0085	COG1086	Polysaccharide biosynthesis protein
AFAEC_0087	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
AFAEC_0088	COG0148	phosphopyruvate hydratase activity
AFAEC_0091	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
AFAEC_0096	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
AFAEC_0097	COG0828	Belongs to the bacterial ribosomal protein bS21 family
AFAEC_0098	COG0315	cyclic pyranopterin monophosphate synthase activity
AFAEC_0101	COG1007	ATP synthesis coupled electron transport
AFAEC_0103	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AFAEC_0104	COG0713	ATP synthesis coupled electron transport
AFAEC_0105	COG0839	Belongs to the complex I subunit 6 family
AFAEC_0106	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AFAEC_0107	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
AFAEC_0111	COG0649	NAD binding
AFAEC_0112	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AFAEC_0113	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AFAEC_0114	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AFAEC_0115	COG1222	aaa ATPase
AFAEC_0118	COG0659	secondary active sulfate transmembrane transporter activity
AFAEC_0121	COG2814	Major facilitator Superfamily
AFAEC_0123	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AFAEC_0124	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AFAEC_0126	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
AFAEC_0127	COG1252	NADH dehydrogenase
AFAEC_0129	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
AFAEC_0130	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AFAEC_0131	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AFAEC_0132	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AFAEC_0133	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
AFAEC_0137	COG2239	Acts as a magnesium transporter
AFAEC_0138	COG0445	tRNA wobble uridine modification
AFAEC_0140	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
AFAEC_0152	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AFAEC_0153	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AFAEC_0155	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AFAEC_0156	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AFAEC_0157	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AFAEC_0160	COG0101	tRNA pseudouridine synthase activity
AFAEC_0162	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AFAEC_0163	COG0443	Heat shock 70 kDa protein
AFAEC_0165	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
AFAEC_0167	COG0688	phosphatidylethanolamine metabolic process
AFAEC_0168	COG2199	diguanylate cyclase activity
AFAEC_0168	COG2200	EAL domain
AFAEC_0168	COG3287	FIST C domain
AFAEC_0171	COG0189	ligase activity
AFAEC_0173	COG3118	belongs to the thioredoxin family
AFAEC_0180	COG0642	Histidine kinase
AFAEC_0181	COG0745	RESPONSE REGULATOR receiver
AFAEC_0183	COG0129	dihydroxy-acid dehydratase activity
AFAEC_0189	COG0577	efflux transmembrane transporter activity
AFAEC_0189	COG1136	(ABC) transporter
AFAEC_0191	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
AFAEC_0192	COG0585	pseudouridine synthase activity
AFAEC_0195	COG0793	Belongs to the peptidase S41A family
AFAEC_0197	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AFAEC_0198	COG0047	phosphoribosylformylglycinamidine synthase activity
AFAEC_0200	COG0204	Acyl-transferase
AFAEC_0201	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AFAEC_0202	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AFAEC_0203	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AFAEC_0204	COG0018	arginyl-trna synthetase
AFAEC_0206	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
AFAEC_0208	COG0126	phosphoglycerate kinase activity
AFAEC_0209	COG0149	triose-phosphate isomerase activity
AFAEC_0210	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
AFAEC_0211	COG0019	diaminopimelate decarboxylase activity
AFAEC_0212	COG1605	Chorismate mutase
AFAEC_0212	COG0077	Prephenate dehydratase
AFAEC_0213	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AFAEC_0214	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
AFAEC_0216	COG0424	maF-like protein
AFAEC_0218	COG0791	NLP P60 protein
AFAEC_0219	COG0791	NLP P60 protein
AFAEC_0222	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AFAEC_0223	COG3118	belongs to the thioredoxin family
AFAEC_0224	COG0492	ferredoxin-NADP+ reductase activity
AFAEC_0225	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
AFAEC_0226	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
AFAEC_0227	COG1242	4 iron, 4 sulfur cluster binding
AFAEC_0230	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AFAEC_0231	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
AFAEC_0232	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
AFAEC_0233	COG3278	Belongs to the heme-copper respiratory oxidase family
AFAEC_0243	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
AFAEC_0244	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AFAEC_0245	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AFAEC_0246	COG1185	polyribonucleotide nucleotidyltransferase activity
AFAEC_0246	COG0539	negative regulation of cytoplasmic translation
AFAEC_0247	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
AFAEC_0248	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
AFAEC_0249	COG0072	phenylalanine-tRNA ligase activity
AFAEC_0249	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AFAEC_0250	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
AFAEC_0251	COG0537	adenosine 5'-monophosphoramidase activity
AFAEC_0252	COG0825	malonyl-CoA metabolic process
AFAEC_0253	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AFAEC_0254	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AFAEC_0256	COG0602	queuosine metabolic process
AFAEC_0258	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
AFAEC_0260	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AFAEC_0263	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
AFAEC_0265	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
AFAEC_0266	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AFAEC_0267	COG1074	ATP-dependent DNA helicase activity
AFAEC_0268	COG0352	thiamine-phosphate diphosphorylase activity
AFAEC_0269	COG0356	it plays a direct role in the translocation of protons across the membrane
AFAEC_0270	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AFAEC_0273	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AFAEC_0275	COG0586	Pfam SNARE associated Golgi protein
AFAEC_0276	COG0335	large ribosomal subunit rRNA binding
AFAEC_0277	COG0336	Belongs to the RNA methyltransferase TrmD family
AFAEC_0279	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
AFAEC_0280	COG0251	oxidation-reduction process
AFAEC_0281	COG2183	response to ionizing radiation
AFAEC_0293	COG1840	ABC-type Fe3 transport system, periplasmic component
AFAEC_0302	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AFAEC_0303	COG0768	penicillin binding
AFAEC_0304	COG0772	Belongs to the SEDS family
AFAEC_0305	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AFAEC_0306	COG1968	undecaprenyl-diphosphatase activity
AFAEC_0307	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
AFAEC_0309	COG0314	molybdopterin synthase activity
AFAEC_0311	COG0174	glutamine synthetase
AFAEC_0313	COG0444	Belongs to the ABC transporter superfamily
AFAEC_0314	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
AFAEC_0315	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AFAEC_0316	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
AFAEC_0321	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AFAEC_0322	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AFAEC_0325	COG0250	Participates in transcription elongation, termination and antitermination
AFAEC_0326	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
AFAEC_0327	COG0081	regulation of translation
AFAEC_0328	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
AFAEC_0329	COG0222	ribosome binding
AFAEC_0330	COG0085	RNA polymerase activity
AFAEC_0331	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AFAEC_0334	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AFAEC_0335	COG1116	anion transmembrane transporter activity
AFAEC_0338	COG4771	TonB-dependent receptor
AFAEC_0340	COG0450	alkyl hydroperoxide reductase
AFAEC_0341	COG2814	Major facilitator Superfamily
AFAEC_0343	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
AFAEC_0344	COG0049	tRNA binding
AFAEC_0345	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AFAEC_0346	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AFAEC_0347	COG0497	DNA recombination
AFAEC_0348	COG0840	transmembrane signaling receptor activity
AFAEC_0349	COG0826	peptidase U32
AFAEC_0351	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
AFAEC_0353	COG0752	glycyl-tRNA synthetase alpha subunit
AFAEC_0354	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AFAEC_0356	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AFAEC_0356	COG1519	Transferase
AFAEC_0357	COG0564	pseudouridine synthase activity
AFAEC_0358	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
AFAEC_0359	COG0228	four-way junction DNA binding
AFAEC_0360	COG1837	Belongs to the UPF0109 family
AFAEC_0361	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
AFAEC_0365	COG0745	RESPONSE REGULATOR receiver
AFAEC_0367	COG4786	Flagellar basal body rod
AFAEC_0368	COG1815	bacterial-type flagellum-dependent cell motility
AFAEC_0369	COG1766	The M ring may be actively involved in energy transduction
AFAEC_0370	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AFAEC_0372	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AFAEC_0374	COG4786	Flagellar basal body rod
AFAEC_0379	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AFAEC_0383	COG1419	protein localization to endoplasmic reticulum
AFAEC_0384	COG0455	bacterial-type flagellum organization
AFAEC_0386	COG1677	Flagellar hook-basal body complex protein FliE
AFAEC_0390	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
AFAEC_0392	COG1157	protein secretion by the type III secretion system
AFAEC_0393	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AFAEC_0394	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
AFAEC_0396	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AFAEC_0398	COG1970	mechanosensitive ion channel activity
AFAEC_0403	COG2030	dehydratase
AFAEC_0406	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
AFAEC_0407	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
AFAEC_0408	COG0542	response to heat
AFAEC_0418	COG4773	Receptor
AFAEC_0419	COG2207	Transcriptional regulator
AFAEC_0419	COG4753	response regulator
AFAEC_0420	COG3852	Histidine kinase
AFAEC_0421	COG1295	ribonuclease BN
AFAEC_0422	COG0277	FAD linked oxidase domain protein
AFAEC_0424	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AFAEC_0425	COG2226	methyltransferase
AFAEC_0429	COG1739	Uncharacterized protein family UPF0029
AFAEC_0433	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AFAEC_0434	COG0697	spore germination
AFAEC_0435	COG2877	3-deoxy-8-phosphooctulonate synthase activity
AFAEC_0436	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
AFAEC_0439	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
AFAEC_0440	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AFAEC_0441	COG0284	orotidine-5'-phosphate decarboxylase activity
AFAEC_0453	COG0483	inositol monophosphate 1-phosphatase activity
AFAEC_0454	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
AFAEC_0459	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
AFAEC_0467	COG1216	Glycosyl transferase, family 2
AFAEC_0469	COG1696	Membrane protein involved in D-alanine export
AFAEC_0471	COG1696	Membrane protein involved in D-alanine export
AFAEC_0474	COG0438	transferase activity, transferring glycosyl groups
AFAEC_0479	COG0859	PFAM glycosyl transferase family 9
AFAEC_0482	COG1368	sulfuric ester hydrolase activity
AFAEC_0483	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
AFAEC_0484	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
AFAEC_0484	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
AFAEC_0486	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
AFAEC_0488	COG0227	Belongs to the bacterial ribosomal protein bL28 family
AFAEC_0490	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
AFAEC_0493	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AFAEC_0495	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
AFAEC_0502	COG1054	Belongs to the UPF0176 family
AFAEC_0506	COG1570	exodeoxyribonuclease VII activity
AFAEC_0507	COG0835	chemotaxis
AFAEC_0510	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
AFAEC_0511	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
AFAEC_0514	COG0459	protein refolding
AFAEC_0516	COG0745	RESPONSE REGULATOR receiver
AFAEC_0517	COG2205	protein histidine kinase activity
AFAEC_0519	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AFAEC_0520	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
AFAEC_0521	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
AFAEC_0522	COG0352	thiamine-phosphate diphosphorylase activity
AFAEC_0523	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
AFAEC_0525	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AFAEC_0526	COG2264	protein methyltransferase activity
AFAEC_0527	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AFAEC_0530	COG0628	permease
AFAEC_0531	COG2255	four-way junction helicase activity
AFAEC_0532	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
AFAEC_0533	COG0159	tryptophan synthase activity
AFAEC_0534	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
AFAEC_0536	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
AFAEC_0539	COG0716	FMN binding
AFAEC_0544	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AFAEC_0546	COG4191	Histidine kinase
AFAEC_0552	COG0739	heme binding
AFAEC_0561	COG1475	DNA binding
AFAEC_0562	COG0270	DNA (cytosine-5-)-methyltransferase activity
AFAEC_0566	COG5499	transcription regulator containing HTH domain
AFAEC_0575	COG0305	Participates in initiation and elongation during chromosome replication
AFAEC_0609	COG0741	lytic transglycosylase activity
AFAEC_0609	COG0739	heme binding
AFAEC_0609	COG1196	nuclear chromosome segregation
AFAEC_0610	COG0582	viral genome integration into host DNA
AFAEC_0615	COG2326	polyphosphate kinase activity
AFAEC_0616	COG0544	peptidyl-prolyl cis-trans isomerase activity
AFAEC_0617	COG0740	serine-type endopeptidase activity
AFAEC_0618	COG0242	peptide deformylase activity
AFAEC_0620	COG0606	chelatase, subunit chli
AFAEC_0621	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AFAEC_0624	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
AFAEC_0626	COG2095	MarC family integral membrane protein
AFAEC_0627	COG3706	GGDEF domain
AFAEC_0628	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
AFAEC_0629	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
AFAEC_0633	COG0481	GTPase activity
AFAEC_0636	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AFAEC_0638	COG0482	sulfurtransferase activity
AFAEC_0639	COG0482	sulfurtransferase activity
AFAEC_0640	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
AFAEC_0641	COG0006	proline dipeptidase activity
AFAEC_0642	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
AFAEC_0643	COG0402	S-adenosylhomocysteine deaminase activity
AFAEC_0644	COG0616	signal peptide processing
AFAEC_0646	COG0280	phosphate acetyltransferase
AFAEC_0647	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AFAEC_0648	COG2176	DNA-directed DNA polymerase activity
AFAEC_0650	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AFAEC_0654	COG2176	DNA-directed DNA polymerase activity
AFAEC_0656	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AFAEC_0658	COG0745	RESPONSE REGULATOR receiver
AFAEC_0668	COG1058	Belongs to the CinA family
AFAEC_0668	COG1546	Belongs to the CinA family
AFAEC_0669	COG0579	oxidoreductase
AFAEC_0670	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AFAEC_0674	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AFAEC_0675	COG0052	Belongs to the universal ribosomal protein uS2 family
AFAEC_0676	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
AFAEC_0677	COG1136	(ABC) transporter
AFAEC_0679	COG0194	GDP metabolic process
AFAEC_0680	COG5001	Diguanylate cyclase
AFAEC_0680	COG5002	protein histidine kinase activity
AFAEC_0681	COG2217	Heavy metal translocating P-type atpase
AFAEC_0685	COG4608	Belongs to the ABC transporter superfamily
AFAEC_0686	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
AFAEC_0687	COG1227	inorganic diphosphatase activity
AFAEC_0688	COG0668	transmembrane transport
AFAEC_0689	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
AFAEC_0691	COG2207	Transcriptional regulator
AFAEC_0693	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AFAEC_0698	COG4773	Receptor
AFAEC_0700	COG0010	Belongs to the arginase family
AFAEC_0709	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AFAEC_0710	COG1136	(ABC) transporter
AFAEC_0710	COG0577	efflux transmembrane transporter activity
AFAEC_0711	COG1538	Outer membrane efflux protein
AFAEC_0713	COG1278	Cold shock
AFAEC_0714	COG4335	DNA alkylation repair
AFAEC_0715	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
AFAEC_0721	COG2995	paraquat-inducible protein a
AFAEC_0723	COG0753	catalase activity
AFAEC_0725	COG3111	PFAM Bacterial OB fold (BOF) protein
AFAEC_0726	COG0642	Histidine kinase
AFAEC_0727	COG0745	RESPONSE REGULATOR receiver
AFAEC_0735	COG0326	Molecular chaperone. Has ATPase activity
AFAEC_0737	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
AFAEC_0738	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
AFAEC_0739	COG0840	transmembrane signaling receptor activity
AFAEC_0740	COG0840	transmembrane signaling receptor activity
AFAEC_0743	COG0513	Belongs to the DEAD box helicase family
AFAEC_0745	COG0259	pyridoxamine-phosphate oxidase activity
AFAEC_0747	COG5002	protein histidine kinase activity
AFAEC_0748	COG1121	(ABC) transporter
AFAEC_0749	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AFAEC_0750	COG2996	Protein conserved in bacteria
AFAEC_0751	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
AFAEC_0753	COG0114	fumarate hydratase activity
AFAEC_0756	COG0210	DNA helicase
AFAEC_0757	COG0475	glutathione-regulated potassium exporter activity
AFAEC_0757	COG0569	domain protein
AFAEC_0758	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
AFAEC_0763	COG3258	Cytochrome c
AFAEC_0781	COG1921	L-seryl-tRNASec selenium transferase activity
AFAEC_0787	COG4774	siderophore transport
AFAEC_0789	COG0709	Synthesizes selenophosphate from selenide and ATP
AFAEC_0790	COG1305	Transglutaminase-like
AFAEC_0796	COG1309	transcriptional regulator
AFAEC_0797	COG4565	transcriptional regulatory protein
AFAEC_0804	COG0437	4 iron, 4 sulfur cluster binding
AFAEC_0806	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
AFAEC_0808	COG0303	'Molybdopterin
AFAEC_0809	COG0446	pyridine nucleotide-disulphide oxidoreductase
AFAEC_0811	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AFAEC_0812	COG0306	phosphate transporter
AFAEC_0814	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AFAEC_0815	COG0328	RNA-DNA hybrid ribonuclease activity
AFAEC_0816	COG0840	transmembrane signaling receptor activity
AFAEC_0819	COG0640	Transcriptional regulator
AFAEC_0820	COG2217	Heavy metal translocating P-type atpase
AFAEC_0827	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AFAEC_0828	COG0508	dehydrogenase complex catalyzes the overall conversion of
AFAEC_0829	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
AFAEC_0830	COG0095	Lipoate-protein ligase
AFAEC_0831	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AFAEC_0834	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
AFAEC_0835	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AFAEC_0835	COG0519	Catalyzes the synthesis of GMP from XMP
AFAEC_0840	COG2267	carboxylic ester hydrolase activity
AFAEC_0843	COG1696	Membrane protein involved in D-alanine export
AFAEC_0844	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
AFAEC_0844	COG0116	Belongs to the methyltransferase superfamily
AFAEC_0846	COG2989	Protein conserved in bacteria
AFAEC_0849	COG4535	Mg2 and Co2 transporter CorC
AFAEC_0850	COG0628	permease
AFAEC_0856	COG3706	GGDEF domain
AFAEC_0858	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AFAEC_0862	COG0301	tRNA thio-modification
AFAEC_0862	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AFAEC_0865	COG2814	Major facilitator Superfamily
AFAEC_0869	COG2354	Protein conserved in bacteria
AFAEC_0870	COG0726	polysaccharide deacetylase
AFAEC_0871	COG2081	HI0933 family
AFAEC_0876	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
AFAEC_0877	COG2171	N-acyltransferase activity
AFAEC_0880	COG0488	(ABC) transporter
AFAEC_0881	COG3135	benzoate transporter
AFAEC_0882	COG2258	MOSC domain
AFAEC_0883	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AFAEC_0885	COG1335	isochorismatase
AFAEC_0887	COG1944	ATP diphosphatase activity
AFAEC_0888	COG4943	cyclic-guanylate-specific phosphodiesterase activity
AFAEC_0891	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AFAEC_0894	COG0745	RESPONSE REGULATOR receiver
AFAEC_0897	COG0189	ligase activity
AFAEC_0897	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AFAEC_0906	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
AFAEC_0910	COG4263	nitrous-oxide reductase activity
AFAEC_0913	COG0437	4 iron, 4 sulfur cluster binding
AFAEC_0916	COG0348	domain, Protein
AFAEC_0917	COG1122	ATPase activity
AFAEC_0921	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AFAEC_0922	COG1611	Belongs to the LOG family
AFAEC_0926	COG0217	transcriptional regulatory protein
AFAEC_0932	COG1049	propionate catabolic process, 2-methylcitrate cycle
AFAEC_0933	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
AFAEC_0935	COG1451	nucleotide metabolic process
AFAEC_0939	COG2884	Cell division ATP-binding protein ftsE
AFAEC_0940	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AFAEC_0942	COG0564	pseudouridine synthase activity
AFAEC_0943	COG0772	Belongs to the SEDS family
AFAEC_0944	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
AFAEC_0945	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AFAEC_0946	COG3123	guanosine phosphorylase activity
AFAEC_0949	COG1090	epimerase
AFAEC_0951	COG0415	Belongs to the DNA photolyase family
AFAEC_0952	COG3275	phosphorelay sensor kinase activity
AFAEC_0953	COG3279	Response regulator of the LytR AlgR family
AFAEC_0955	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AFAEC_0956	COG0071	Belongs to the small heat shock protein (HSP20) family
AFAEC_0958	COG1132	(ABC) transporter
AFAEC_0960	COG0745	RESPONSE REGULATOR receiver
AFAEC_0961	COG0642	Histidine kinase
AFAEC_0967	COG0653	protein targeting
AFAEC_0968	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
AFAEC_0970	COG0546	phosphoglycolate phosphatase activity
AFAEC_0975	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AFAEC_0977	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AFAEC_0978	COG0697	spore germination
AFAEC_0979	COG0513	Belongs to the DEAD box helicase family
AFAEC_0981	COG0745	RESPONSE REGULATOR receiver
AFAEC_0988	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
AFAEC_0989	COG2363	Small membrane protein
AFAEC_0990	COG1666	GTP binding
AFAEC_0991	COG0745	RESPONSE REGULATOR receiver
AFAEC_0992	COG0642	Histidine kinase
AFAEC_0993	COG0494	nUDIX hydrolase
AFAEC_0996	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AFAEC_0997	COG0135	phosphoribosylanthranilate isomerase activity
AFAEC_0998	COG2176	DNA-directed DNA polymerase activity
AFAEC_1002	COG0667	Aldo Keto reductase
AFAEC_1004	COG5000	phosphorelay sensor kinase activity
AFAEC_1009	COG0745	RESPONSE REGULATOR receiver
AFAEC_1011	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AFAEC_1012	COG0066	3-isopropylmalate dehydratase activity
AFAEC_1013	COG0473	3-isopropylmalate dehydrogenase activity
AFAEC_1016	COG0257	Belongs to the bacterial ribosomal protein bL36 family
AFAEC_1017	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
AFAEC_1018	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
AFAEC_1019	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
AFAEC_1020	COG0202	RNA polymerase activity
AFAEC_1021	COG0203	ribosomal protein L17
AFAEC_1022	COG0154	amidase activity
AFAEC_1023	COG0516	GMP reductase activity
AFAEC_1023	COG0517	IMP dehydrogenase activity
AFAEC_1024	COG0840	transmembrane signaling receptor activity
AFAEC_1026	COG3706	GGDEF domain
AFAEC_1027	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AFAEC_1029	COG1496	oxidoreductase activity
AFAEC_1030	COG0788	formyltetrahydrofolate deformylase activity
AFAEC_1031	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
AFAEC_1034	COG0745	RESPONSE REGULATOR receiver
AFAEC_1041	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
AFAEC_1043	COG1393	Belongs to the ArsC family
AFAEC_1045	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AFAEC_1047	COG0849	cell division
AFAEC_1048	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AFAEC_1049	COG2391	methyltransferase activity
AFAEC_1051	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AFAEC_1052	COG1722	exodeoxyribonuclease VII activity
AFAEC_1053	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AFAEC_1055	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AFAEC_1059	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
AFAEC_1061	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AFAEC_1062	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AFAEC_1064	COG0521	Mo-molybdopterin cofactor biosynthetic process
AFAEC_1065	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AFAEC_1068	COG0454	-acetyltransferase
AFAEC_1071	COG4774	siderophore transport
AFAEC_1073	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
AFAEC_1076	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
AFAEC_1077	COG0298	carbon dioxide binding
AFAEC_1080	COG2084	Dehydrogenase
AFAEC_1082	COG0309	Hydrogenase expression formation protein (HypE)
AFAEC_1085	COG0310	cobalt ion transport
AFAEC_1090	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AFAEC_1093	COG1696	Membrane protein involved in D-alanine export
AFAEC_1094	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AFAEC_1095	COG0137	argininosuccinate synthase activity
AFAEC_1097	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AFAEC_1099	COG1137	ATPase activity
AFAEC_1139	COG0582	viral genome integration into host DNA
AFAEC_1142	COG0339	signal peptide processing
AFAEC_1143	COG2890	protein-(glutamine-N5) methyltransferase activity
AFAEC_1144	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AFAEC_1145	COG0494	nUDIX hydrolase
AFAEC_1146	COG0527	aspartate kinase activity
AFAEC_1149	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AFAEC_1152	COG0166	Belongs to the GPI family
AFAEC_1156	COG0708	Exodeoxyribonuclease III
AFAEC_1158	COG0500	methyltransferase
AFAEC_1159	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AFAEC_1159	COG1333	cytochrome c biogenesis protein
AFAEC_1160	COG2195	Cleaves the N-terminal amino acid of tripeptides
AFAEC_1161	COG2200	EAL domain
AFAEC_1161	COG3287	FIST C domain
AFAEC_1161	COG2199	diguanylate cyclase activity
AFAEC_1164	COG1253	flavin adenine dinucleotide binding
AFAEC_1165	COG1193	negative regulation of DNA recombination
AFAEC_1166	COG2249	NAD(P)H dehydrogenase (quinone) activity
AFAEC_1173	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
AFAEC_1174	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
AFAEC_1175	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
AFAEC_1180	COG0484	heat shock protein binding
AFAEC_1184	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AFAEC_1185	COG5001	Diguanylate cyclase
AFAEC_1186	COG2203	Gaf domain
AFAEC_1186	COG3706	GGDEF domain
AFAEC_1186	COG4251	negative regulation of phosphorylation
AFAEC_1186	COG5001	Diguanylate cyclase
AFAEC_1187	COG0287	Prephenate dehydrogenase
AFAEC_1188	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AFAEC_1189	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
AFAEC_1190	COG0612	Peptidase, M16
AFAEC_1191	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AFAEC_1196	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
AFAEC_1198	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AFAEC_1198	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AFAEC_1201	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
AFAEC_1202	COG2201	protein-glutamate methylesterase activity
AFAEC_1203	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
AFAEC_1204	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
AFAEC_1205	COG0643	Histidine kinase
AFAEC_1205	COG2198	Histidine kinase
AFAEC_1206	COG0745	RESPONSE REGULATOR receiver
AFAEC_1207	COG1185	polyribonucleotide nucleotidyltransferase activity
AFAEC_1209	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
AFAEC_1213	COG0659	secondary active sulfate transmembrane transporter activity
AFAEC_1214	COG1160	GTP binding
AFAEC_1217	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
AFAEC_1223	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
AFAEC_1223	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AFAEC_1224	COG2201	protein-glutamate methylesterase activity
AFAEC_1227	COG0484	heat shock protein binding
AFAEC_1228	COG0789	Transcriptional regulator
AFAEC_1231	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AFAEC_1231	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AFAEC_1232	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AFAEC_1233	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AFAEC_1234	COG4774	siderophore transport
AFAEC_1235	COG1663	tetraacyldisaccharide 4'-kinase activity
AFAEC_1236	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
AFAEC_1237	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
AFAEC_1240	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
AFAEC_1241	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AFAEC_1242	COG0805	protein transport
AFAEC_1243	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
AFAEC_1244	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AFAEC_1247	COG0247	lactate metabolic process
AFAEC_1247	COG2181	nitrate reductase activity
AFAEC_1248	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
AFAEC_1251	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AFAEC_1251	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AFAEC_1252	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
AFAEC_1255	COG0275	rRNA processing
AFAEC_1257	COG0776	regulation of translation
AFAEC_1267	COG0357	Ribosomal RNA small subunit methyltransferase G
AFAEC_1268	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AFAEC_1269	COG0113	porphobilinogen synthase activity
AFAEC_1272	COG0861	Integral membrane protein TerC family
AFAEC_1273	COG1114	Component of the transport system for branched-chain amino acids
AFAEC_1275	COG1196	nuclear chromosome segregation
AFAEC_1275	COG1674	ftsk spoiiie
AFAEC_1276	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AFAEC_1277	COG0440	acetolactate synthase activity
AFAEC_1278	COG0028	Belongs to the TPP enzyme family
AFAEC_1280	COG0248	Ppx GppA phosphatase
AFAEC_1282	COG2203	Gaf domain
AFAEC_1282	COG3706	GGDEF domain
AFAEC_1282	COG5001	Diguanylate cyclase
AFAEC_1282	COG4251	negative regulation of phosphorylation
AFAEC_1285	COG3118	belongs to the thioredoxin family
AFAEC_1287	COG0037	tRNA processing
AFAEC_1289	COG0303	'Molybdopterin
AFAEC_1291	COG2321	neutral zinc metallopeptidase
AFAEC_1292	COG1322	Protein conserved in bacteria
AFAEC_1293	COG0501	Belongs to the peptidase M48B family
AFAEC_1295	COG0824	Thioesterase
AFAEC_1297	COG1086	Polysaccharide biosynthesis protein
AFAEC_1298	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
AFAEC_1299	COG0110	maltose O-acetyltransferase activity
AFAEC_1300	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AFAEC_1301	COG0438	transferase activity, transferring glycosyl groups
AFAEC_1302	COG0438	transferase activity, transferring glycosyl groups
AFAEC_1303	COG0367	asparagine synthase
AFAEC_1307	COG1028	Short-chain dehydrogenase reductase Sdr
AFAEC_1309	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AFAEC_1310	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AFAEC_1316	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
AFAEC_1317	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
AFAEC_1327	COG0840	transmembrane signaling receptor activity
AFAEC_1328	COG0322	excinuclease ABC activity
AFAEC_1329	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AFAEC_1332	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
AFAEC_1334	COG0768	penicillin binding
AFAEC_1335	COG1338	Plays a role in the flagellum-specific transport system
AFAEC_1336	COG3437	response regulator, receiver
AFAEC_1336	COG0784	Response regulator, receiver
AFAEC_1338	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AFAEC_1341	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AFAEC_1342	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
AFAEC_1343	COG0488	(ABC) transporter
AFAEC_1345	COG0778	Nitroreductase
AFAEC_1346	COG2249	NAD(P)H dehydrogenase (quinone) activity
AFAEC_1347	COG1733	regulation of RNA biosynthetic process
AFAEC_1349	COG2855	membrane
AFAEC_1350	COG0583	DNA-binding transcription factor activity
AFAEC_1352	COG1881	PFAM PEBP family protein
AFAEC_1354	COG0642	Histidine kinase
AFAEC_1357	COG3258	Cytochrome c
AFAEC_1360	COG2076	Multidrug Resistance protein
AFAEC_1361	COG1119	ATPase activity
AFAEC_1363	COG0754	glutathionylspermidine amidase activity
AFAEC_1364	COG0840	transmembrane signaling receptor activity
AFAEC_1367	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AFAEC_1370	COG0840	transmembrane signaling receptor activity
AFAEC_1373	COG0840	transmembrane signaling receptor activity
AFAEC_1374	COG0840	transmembrane signaling receptor activity
AFAEC_1375	COG0840	transmembrane signaling receptor activity
AFAEC_1376	COG1595	DNA-templated transcription, initiation
AFAEC_1379	COG1472	Belongs to the glycosyl hydrolase 3 family
AFAEC_1381	COG0484	heat shock protein binding
AFAEC_1384	COG1607	acyl-coa hydrolase
AFAEC_1385	COG0456	acetyltransferase
AFAEC_1386	COG0218	Necessary for normal cell division and for the maintenance of normal septation
AFAEC_1389	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
AFAEC_1390	COG0131	Imidazoleglycerol-phosphate dehydratase
AFAEC_1391	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
AFAEC_1392	COG0741	lytic transglycosylase activity
AFAEC_1392	COG1388	LysM domain
AFAEC_1393	COG0084	hydrolase, TatD family'
AFAEC_1396	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
AFAEC_1397	COG0359	binds to the 23S rRNA
AFAEC_1399	COG0163	prenyltransferase activity
AFAEC_1400	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
AFAEC_1401	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AFAEC_1402	COG0124	histidyl-tRNA synthetase
AFAEC_1403	COG1166	arginine decarboxylase activity
AFAEC_1404	COG1045	serine acetyltransferase
AFAEC_1405	COG0730	response to heat
AFAEC_1407	COG0492	ferredoxin-NADP+ reductase activity
AFAEC_1408	COG0488	(ABC) transporter
AFAEC_1410	COG3706	GGDEF domain
AFAEC_1411	COG0157	Belongs to the NadC ModD family
AFAEC_1413	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AFAEC_1414	COG0742	ribosomal rna small subunit methyltransferase
AFAEC_1415	COG1418	mRNA catabolic process
AFAEC_1418	COG0552	protein localization to endoplasmic reticulum
AFAEC_1421	COG1858	cytochrome C peroxidase
AFAEC_1426	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
AFAEC_1428	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
AFAEC_1429	COG0735	belongs to the Fur family
AFAEC_1431	COG0728	peptidoglycan biosynthetic process
AFAEC_1432	COG1132	(ABC) transporter
AFAEC_1433	COG0167	dihydroorotate dehydrogenase activity
AFAEC_1435	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AFAEC_1436	COG1028	Short-chain dehydrogenase reductase Sdr
AFAEC_1437	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AFAEC_1438	COG0750	zinc metalloprotease
AFAEC_1439	COG0840	transmembrane signaling receptor activity
AFAEC_1441	COG0840	transmembrane signaling receptor activity
AFAEC_1447	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
AFAEC_1448	COG1942	4-Oxalocrotonate Tautomerase
AFAEC_1449	COG0583	DNA-binding transcription factor activity
AFAEC_1452	COG2203	Gaf domain
AFAEC_1452	COG3706	GGDEF domain
AFAEC_1452	COG5001	Diguanylate cyclase
AFAEC_1452	COG4251	negative regulation of phosphorylation
AFAEC_1454	COG0745	RESPONSE REGULATOR receiver
AFAEC_1455	COG0642	Histidine kinase
AFAEC_1456	COG2081	HI0933 family
AFAEC_1458	COG0745	RESPONSE REGULATOR receiver
AFAEC_1461	COG1692	metallophosphoesterase
AFAEC_1462	COG0134	indole-3-glycerol-phosphate synthase activity
AFAEC_1464	COG0727	PFAM Uncharacterised protein family (UPF0153)
AFAEC_1465	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
AFAEC_1467	COG0674	pyruvate-flavodoxin oxidoreductase activity
AFAEC_1467	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
AFAEC_1468	COG1013	pyruvate-flavodoxin oxidoreductase activity
AFAEC_1470	COG1979	alcohol dehydrogenase
AFAEC_1475	COG2207	Transcriptional regulator
AFAEC_1476	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
AFAEC_1479	COG0563	adenylate kinase activity
AFAEC_1483	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
AFAEC_1485	COG1573	uracil-dna glycosylase
AFAEC_1486	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
AFAEC_1487	COG0024	Methionine aminopeptidase
AFAEC_1488	COG0201	protein transport
AFAEC_1489	COG0200	Binds to the 23S rRNA
AFAEC_1490	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
AFAEC_1491	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
AFAEC_1492	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
AFAEC_1493	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
AFAEC_1494	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
AFAEC_1495	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
AFAEC_1496	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
AFAEC_1497	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
AFAEC_1498	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
AFAEC_1499	COG0255	Belongs to the universal ribosomal protein uL29 family
AFAEC_1500	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
AFAEC_1501	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
AFAEC_1502	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
AFAEC_1503	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AFAEC_1504	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
AFAEC_1505	COG0089	rRNA binding
AFAEC_1506	COG0088	Forms part of the polypeptide exit tunnel
AFAEC_1507	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
AFAEC_1508	COG0051	transcription antitermination factor activity, RNA binding
AFAEC_1511	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AFAEC_1513	COG1181	Belongs to the D-alanine--D-alanine ligase family
AFAEC_1514	COG0632	four-way junction helicase activity
AFAEC_1515	COG0840	transmembrane signaling receptor activity
AFAEC_1517	COG0585	pseudouridine synthase activity
AFAEC_1518	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
AFAEC_1520	COG3123	guanosine phosphorylase activity
AFAEC_1524	COG0012	GTP binding
AFAEC_1525	COG1966	Carbon starvation protein
AFAEC_1529	COG0500	methyltransferase
AFAEC_1530	COG4771	TonB-dependent receptor
AFAEC_1539	COG1136	(ABC) transporter
AFAEC_1539	COG0577	efflux transmembrane transporter activity
AFAEC_1540	COG1136	(ABC) transporter
AFAEC_1540	COG0577	efflux transmembrane transporter activity
AFAEC_1543	COG0811	peptide transport
AFAEC_1544	COG0848	biopolymer transport protein
AFAEC_1546	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AFAEC_1548	COG0133	tryptophan synthase activity
AFAEC_1549	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AFAEC_1550	COG1793	dna ligase
AFAEC_1551	COG2165	general secretion pathway protein
AFAEC_1552	COG0305	Participates in initiation and elongation during chromosome replication
AFAEC_1553	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
AFAEC_1556	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
AFAEC_1557	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AFAEC_1559	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AFAEC_1560	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
AFAEC_1561	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
AFAEC_1563	COG0528	UMP kinase activity
AFAEC_1564	COG1758	RNA polymerase activity
AFAEC_1565	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AFAEC_1566	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AFAEC_1568	COG0860	N-Acetylmuramoyl-L-alanine amidase
AFAEC_1576	COG0193	aminoacyl-tRNA hydrolase activity
AFAEC_1577	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
AFAEC_1578	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AFAEC_1579	COG0681	Belongs to the peptidase S26 family
AFAEC_1580	COG0698	ribose 5-phosphate isomerase
AFAEC_1583	COG0840	transmembrane signaling receptor activity
AFAEC_1585	COG0840	transmembrane signaling receptor activity
AFAEC_1588	COG2831	hemolysin activation secretion protein
AFAEC_1592	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AFAEC_1593	COG0556	nucleotide-excision repair
AFAEC_1596	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AFAEC_1597	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
AFAEC_1598	COG0784	Response regulator, receiver
AFAEC_1598	COG0835	chemotaxis
AFAEC_1599	COG0165	Argininosuccinate lyase
AFAEC_1600	COG3706	GGDEF domain
AFAEC_1601	COG4175	Glycine betaine
AFAEC_1601	COG3448	diguanylate cyclase activity
AFAEC_1603	COG0719	Fe-S assembly protein
AFAEC_1604	COG0396	ATPase activity
AFAEC_1606	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AFAEC_1607	COG2166	iron-sulfur cluster assembly
AFAEC_1612	COG0439	Biotin carboxylase
AFAEC_1615	COG2199	diguanylate cyclase activity
AFAEC_1616	COG0840	transmembrane signaling receptor activity
AFAEC_1617	COG0840	transmembrane signaling receptor activity
AFAEC_1619	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
AFAEC_1620	COG0840	transmembrane signaling receptor activity
AFAEC_1621	COG0840	transmembrane signaling receptor activity
AFAEC_1625	COG0535	radical SAM domain protein
AFAEC_1627	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AFAEC_1629	COG2010	Cytochrome c
AFAEC_1631	COG3256	nitric oxide reductase
AFAEC_1632	COG2010	Cytochrome c
AFAEC_1635	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
AFAEC_1636	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AFAEC_1637	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AFAEC_1641	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
AFAEC_1642	COG2814	Major facilitator Superfamily
AFAEC_1645	COG1434	Gram-negative-bacterium-type cell wall biogenesis
AFAEC_1649	COG0525	valine-tRNA ligase activity
AFAEC_1650	COG1846	Transcriptional regulator
AFAEC_1654	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AFAEC_1654	COG1648	precorrin-2 dehydrogenase activity
AFAEC_1655	COG1522	sequence-specific DNA binding
AFAEC_1659	COG1027	Aspartate ammonia-lyase
AFAEC_1660	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AFAEC_1661	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
AFAEC_1662	COG1047	Peptidyl-prolyl cis-trans
AFAEC_1665	COG0823	Involved in the tonB-independent uptake of proteins
AFAEC_1667	COG0848	biopolymer transport protein
AFAEC_1668	COG0811	peptide transport
AFAEC_1669	COG0355	proton-transporting ATP synthase activity, rotational mechanism
AFAEC_1670	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
AFAEC_1671	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
AFAEC_1672	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
AFAEC_1673	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AFAEC_1674	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AFAEC_1676	COG1475	DNA binding
AFAEC_1677	COG1192	Involved in chromosome partitioning
AFAEC_1680	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AFAEC_1681	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
AFAEC_1682	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AFAEC_1683	COG0211	Belongs to the bacterial ribosomal protein bL27 family
AFAEC_1684	COG0261	This protein binds to 23S rRNA in the presence of protein L20
AFAEC_1685	COG0358	DNA primase activity
AFAEC_1687	COG0571	ribonuclease III activity
AFAEC_1688	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
AFAEC_1690	COG2194	sulfuric ester hydrolase activity
AFAEC_1696	COG3755	Protein conserved in bacteria
AFAEC_1699	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AFAEC_1700	COG0642	Histidine kinase
AFAEC_1701	COG0745	RESPONSE REGULATOR receiver
AFAEC_1705	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
AFAEC_1707	COG0706	membrane insertase activity
AFAEC_1708	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
AFAEC_1709	COG0230	Belongs to the bacterial ribosomal protein bL34 family
AFAEC_1710	COG0542	response to heat
AFAEC_1711	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AFAEC_1712	COG2326	polyphosphate kinase activity
AFAEC_1715	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AFAEC_1727	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AFAEC_1729	COG0494	nUDIX hydrolase
AFAEC_1730	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AFAEC_1732	COG0138	bifunctional purine biosynthesis protein purh
AFAEC_1733	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AFAEC_1735	COG0741	lytic transglycosylase activity
AFAEC_1735	COG1196	nuclear chromosome segregation
AFAEC_1735	COG0739	heme binding
AFAEC_1737	COG0598	Magnesium transport protein CorA
AFAEC_1742	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AFAEC_1745	COG0626	cystathionine gamma-synthase activity
AFAEC_1749	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
AFAEC_1750	COG0803	Belongs to the bacterial solute-binding protein 9 family
AFAEC_1752	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AFAEC_1754	COG1858	cytochrome C peroxidase
AFAEC_1760	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AFAEC_1773	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
AFAEC_1779	COG3179	chitinase
AFAEC_1781	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AFAEC_1781	COG0515	serine threonine protein kinase
AFAEC_1804	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
AFAEC_1811	COG0285	dihydrofolate synthase activity
AFAEC_1813	COG0495	leucyl-tRNA aminoacylation
AFAEC_1815	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
AFAEC_1816	COG1360	Flagellar Motor Protein
AFAEC_1819	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AFAEC_1820	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AFAEC_1821	COG1862	Preprotein translocase
AFAEC_1822	COG0815	Transfers the fatty acyl group on membrane lipoproteins
AFAEC_1823	COG0300	oxidoreductase activity
AFAEC_1827	COG0617	tRNA 3'-terminal CCA addition
AFAEC_1828	COG0668	transmembrane transport
AFAEC_1829	COG0442	prolyl-tRNA aminoacylation
AFAEC_1830	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
AFAEC_1831	COG0142	geranyltranstransferase activity
AFAEC_1833	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AFAEC_1834	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
AFAEC_1836	COG0811	peptide transport
AFAEC_1837	COG0848	biopolymer transport protein
AFAEC_1840	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
AFAEC_1841	COG2267	carboxylic ester hydrolase activity
AFAEC_1845	COG4569	acetaldehyde dehydrogenase (acetylating) activity
AFAEC_1851	COG0039	L-malate dehydrogenase activity
AFAEC_1852	COG0730	response to heat
AFAEC_1860	COG2204	response regulator
AFAEC_1862	COG0191	fructose-bisphosphate aldolase activity
AFAEC_1863	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AFAEC_1864	COG0745	RESPONSE REGULATOR receiver
AFAEC_1865	COG0642	Histidine kinase
AFAEC_1867	COG2404	hydrolase activity, acting on ester bonds
AFAEC_1869	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
AFAEC_1870	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AFAEC_1871	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AFAEC_1874	COG0243	molybdopterin cofactor binding
AFAEC_1875	COG0437	4 iron, 4 sulfur cluster binding
AFAEC_1876	COG0348	domain, Protein
AFAEC_1877	COG3043	anaerobic respiration
AFAEC_1881	COG0840	transmembrane signaling receptor activity
AFAEC_1882	COG5002	protein histidine kinase activity
AFAEC_1882	COG5001	Diguanylate cyclase
AFAEC_1884	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
AFAEC_1886	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AFAEC_1887	COG1131	(ABC) transporter
AFAEC_1888	COG0842	Transport permease protein
AFAEC_1889	COG0842	Transport permease protein
AFAEC_1892	COG2207	Transcriptional regulator
AFAEC_1892	COG1609	Transcriptional regulator
AFAEC_1893	COG4771	TonB-dependent receptor
AFAEC_1894	COG2375	cellular response to nickel ion
AFAEC_1894	COG1132	(ABC) transporter
AFAEC_1895	COG1132	(ABC) transporter
AFAEC_1898	COG1971	Probably functions as a manganese efflux pump
AFAEC_1900	COG3706	GGDEF domain
AFAEC_1902	COG4999	Histidine kinase
AFAEC_1902	COG3850	Histidine kinase
AFAEC_1902	COG3437	response regulator, receiver
AFAEC_1902	COG2205	protein histidine kinase activity
AFAEC_1905	COG3204	pilus organization
AFAEC_1907	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
AFAEC_1910	COG2966	Psort location CytoplasmicMembrane, score
AFAEC_1911	COG3610	response to peptide
AFAEC_1912	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
AFAEC_1913	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AFAEC_1914	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AFAEC_1915	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AFAEC_1915	COG0649	NAD binding
AFAEC_1916	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
AFAEC_1918	COG0372	Belongs to the citrate synthase family
AFAEC_1919	COG1034	ATP synthesis coupled electron transport
AFAEC_1920	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
AFAEC_1921	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AFAEC_1922	COG0839	Belongs to the complex I subunit 6 family
AFAEC_1923	COG0713	ATP synthesis coupled electron transport
AFAEC_1924	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AFAEC_1926	COG1007	ATP synthesis coupled electron transport
AFAEC_1928	COG1053	succinate dehydrogenase
AFAEC_1929	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AFAEC_1932	COG2824	Alkylphosphonate utilization operon protein PhnA
AFAEC_1936	COG0840	transmembrane signaling receptor activity
AFAEC_1939	COG0840	transmembrane signaling receptor activity
AFAEC_1940	COG0840	transmembrane signaling receptor activity
AFAEC_1947	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AFAEC_1949	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
AFAEC_1950	COG0372	Belongs to the citrate synthase family
AFAEC_1951	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
AFAEC_1952	COG2828	Protein conserved in bacteria
AFAEC_1953	COG1335	isochorismatase
AFAEC_1954	COG0181	hydroxymethylbilane synthase activity
AFAEC_1956	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
AFAEC_1957	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
AFAEC_1959	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AFAEC_1960	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
AFAEC_1961	COG0450	alkyl hydroperoxide reductase
AFAEC_1963	COG0105	UTP biosynthetic process
AFAEC_1965	COG0333	Belongs to the bacterial ribosomal protein bL32 family
AFAEC_1966	COG0416	fatty acid biosynthetic process
AFAEC_1967	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AFAEC_1971	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AFAEC_1972	COG0540	Belongs to the ATCase OTCase family
AFAEC_1974	COG4773	Receptor
AFAEC_1977	COG1706	bacterial-type flagellum-dependent cell motility
AFAEC_1979	COG1987	bacterial-type flagellum assembly
AFAEC_1984	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
AFAEC_1986	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
AFAEC_1989	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
AFAEC_1991	COG0288	reversible hydration of carbon dioxide
AFAEC_1992	COG0156	8-amino-7-oxononanoate synthase activity
AFAEC_1993	COG0792	nuclease activity
AFAEC_1996	COG2885	chlorophyll binding
AFAEC_2000	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
AFAEC_2001	COG0587	DNA-directed DNA polymerase activity
AFAEC_2002	COG0693	protein deglycase activity
AFAEC_2005	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
AFAEC_2006	COG0504	CTP synthase activity
AFAEC_2007	COG0348	domain, Protein
AFAEC_2009	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AFAEC_2010	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
AFAEC_2011	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
AFAEC_2013	COG0157	Belongs to the NadC ModD family
AFAEC_2014	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
AFAEC_2016	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
AFAEC_2018	COG0083	homoserine kinase activity
AFAEC_2020	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
AFAEC_2021	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
AFAEC_2022	COG0779	Required for maturation of 30S ribosomal subunits
AFAEC_2023	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AFAEC_2023	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AFAEC_2025	COG2121	Domain of unknown function (DUF374)
AFAEC_2026	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AFAEC_2028	COG0195	Participates in both transcription termination and antitermination
AFAEC_2029	COG0215	cysteine-tRNA ligase activity
AFAEC_2031	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
AFAEC_2032	COG0629	single-stranded DNA binding
AFAEC_2033	COG0360	Binds together with S18 to 16S ribosomal RNA
AFAEC_2036	COG0557	exoribonuclease II activity
AFAEC_2037	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
AFAEC_2043	COG0343	queuine tRNA-ribosyltransferase activity
AFAEC_2044	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AFAEC_2045	COG1393	Belongs to the ArsC family
AFAEC_2046	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
AFAEC_2048	COG0560	Phosphoserine phosphatase
AFAEC_2050	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
AFAEC_2052	COG0736	holo-[acyl-carrier-protein] synthase activity
AFAEC_2053	COG0601	transmembrane transport
AFAEC_2054	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
AFAEC_2056	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AFAEC_2058	COG0418	dihydroorotase activity
AFAEC_2060	COG0004	ammonium transporteR
AFAEC_2064	COG1301	dicarboxylic acid transport
AFAEC_2067	COG1742	UPF0060 membrane protein
AFAEC_2068	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
AFAEC_2070	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
AFAEC_2072	COG4191	Histidine kinase
AFAEC_2074	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AFAEC_2077	COG0745	RESPONSE REGULATOR receiver
AFAEC_2080	COG0840	transmembrane signaling receptor activity
AFAEC_2084	COG0511	ligase activity, forming carbon-carbon bonds
AFAEC_2091	COG2022	thiamine diphosphate biosynthetic process
AFAEC_2092	COG1324	tolerance protein
AFAEC_2093	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
AFAEC_2093	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
AFAEC_2095	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
AFAEC_2098	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
AFAEC_2099	COG0575	Belongs to the CDS family
AFAEC_2105	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AFAEC_2107	COG0291	Belongs to the bacterial ribosomal protein bL35 family
AFAEC_2108	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
AFAEC_2112	COG0746	molybdenum cofactor guanylyltransferase activity
AFAEC_2113	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AFAEC_2114	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
AFAEC_2115	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AFAEC_2116	COG0268	Binds directly to 16S ribosomal RNA
AFAEC_2117	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
AFAEC_2118	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AFAEC_2124	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
AFAEC_2125	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
AFAEC_2126	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AFAEC_2128	COG0505	Belongs to the CarA family
AFAEC_2130	COG1686	Belongs to the peptidase S11 family
AFAEC_2133	COG1854	S-ribosylhomocysteine lyase activity
AFAEC_2134	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AFAEC_2141	COG0352	thiamine-phosphate diphosphorylase activity
AFAEC_2141	COG0351	phosphomethylpyrimidine kinase
AFAEC_2143	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
AFAEC_2144	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AFAEC_2145	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
AFAEC_2146	COG5002	protein histidine kinase activity
AFAEC_2147	COG0745	RESPONSE REGULATOR receiver
AFAEC_2149	COG0704	Plays a role in the regulation of phosphate uptake
AFAEC_2150	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AFAEC_2151	COG0581	inorganic phosphate transmembrane transporter activity
AFAEC_2152	COG0573	inorganic phosphate transmembrane transporter activity
AFAEC_2153	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AFAEC_2154	COG0460	homoserine dehydrogenase
AFAEC_2155	COG0436	Aminotransferase
AFAEC_2157	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AFAEC_2158	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
AFAEC_2159	COG0254	rRNA binding
AFAEC_2160	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
AFAEC_2162	COG0109	protoheme IX farnesyltransferase activity
AFAEC_2179	COG0237	dephospho-CoA kinase activity
AFAEC_2180	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
AFAEC_2181	COG1410	methionine synthase
AFAEC_2181	COG0646	methionine synthase
AFAEC_2186	COG0140	phosphoribosyl-ATP diphosphatase activity
AFAEC_2186	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
AFAEC_2188	COG0489	protein tyrosine kinase activity
AFAEC_2191	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
AFAEC_2191	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
AFAEC_2192	COG0745	RESPONSE REGULATOR receiver
AFAEC_2193	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
AFAEC_2195	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AFAEC_2199	COG0642	Histidine kinase
AFAEC_2200	COG0745	RESPONSE REGULATOR receiver
AFAEC_2201	COG0724	RNA recognition motif
AFAEC_2202	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AFAEC_2203	COG0820	rRNA (adenine-C2-)-methyltransferase activity
AFAEC_2206	COG0107	imidazoleglycerol-phosphate synthase activity
AFAEC_2207	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AFAEC_2208	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
AFAEC_2209	COG0517	IMP dehydrogenase activity
AFAEC_2209	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
AFAEC_2210	COG1187	pseudouridine synthase activity
AFAEC_2211	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
AFAEC_2211	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
AFAEC_2212	COG1981	membrane
AFAEC_2213	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
AFAEC_2215	COG0367	asparagine synthase
AFAEC_2217	COG0306	phosphate transporter
AFAEC_2218	COG0513	Belongs to the DEAD box helicase family
AFAEC_2219	COG0439	Biotin carboxylase
AFAEC_2220	COG0511	ligase activity, forming carbon-carbon bonds
AFAEC_2221	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AFAEC_2221	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AFAEC_2222	COG0247	lactate metabolic process
AFAEC_2223	COG1139	Iron-sulfur cluster binding protein
AFAEC_2224	COG1556	Lactate utilization protein
AFAEC_2225	COG3852	Histidine kinase
AFAEC_2226	COG0745	RESPONSE REGULATOR receiver
AFAEC_2227	COG1620	l-lactate permease
AFAEC_2231	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
AFAEC_2232	COG1733	regulation of RNA biosynthetic process
AFAEC_2233	COG0604	alcohol dehydrogenase
AFAEC_2236	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AFAEC_2237	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AFAEC_2238	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AFAEC_2239	COG0564	pseudouridine synthase activity
AFAEC_2243	COG2860	membrane
AFAEC_2244	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
AFAEC_2245	COG2199	diguanylate cyclase activity
AFAEC_2245	COG2203	Gaf domain
AFAEC_2247	COG4771	TonB-dependent receptor
AFAEC_2248	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
AFAEC_2249	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AFAEC_2251	COG0748	coenzyme F420 binding
AFAEC_2254	COG3721	Heme iron utilization protein
AFAEC_2255	COG2391	methyltransferase activity
AFAEC_2256	COG0425	Belongs to the sulfur carrier protein TusA family
AFAEC_2269	COG1217	gtp-binding protein TYPA
AFAEC_2271	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AFAEC_2272	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AFAEC_2273	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AFAEC_2274	COG1116	anion transmembrane transporter activity
AFAEC_2276	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AFAEC_2277	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AFAEC_2279	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AFAEC_2280	COG1116	anion transmembrane transporter activity
AFAEC_2283	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
AFAEC_2284	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AFAEC_2288	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AFAEC_2289	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AFAEC_2291	COG2200	EAL domain
AFAEC_2291	COG2199	diguanylate cyclase activity
AFAEC_2291	COG3287	FIST C domain
AFAEC_2292	COG1045	serine acetyltransferase
AFAEC_2296	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
AFAEC_2297	COG4208	sulfate ABC transporter
AFAEC_2298	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
AFAEC_2300	COG1408	metallophosphoesterase
AFAEC_2303	COG0133	tryptophan synthase activity
AFAEC_2305	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
AFAEC_a0003	COG0582	viral genome integration into host DNA
AFAEC_a0008	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
AFAEC_a0012	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AFAEC_a0014	COG0720	synthase
AFAEC_a0016	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AFAEC_a0017	COG1121	(ABC) transporter
AFAEC_a0018	COG0803	Belongs to the bacterial solute-binding protein 9 family
AFAEC_a0035	COG0784	Response regulator, receiver
AFAEC_a0035	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AFAEC_a0057	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AFAEC_a0057	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
AFAEC_a0061	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
AFAEC_a0065	COG0419	ATPase involved in DNA repair
AFAEC_a0066	COG0420	3'-5' exonuclease activity
AFAEC_a0068	COG1192	Involved in chromosome partitioning
AFAEC_a0069	COG1475	DNA binding
AFAEC_a0071	COG0305	Participates in initiation and elongation during chromosome replication
AFAEC_a0077	COG0450	alkyl hydroperoxide reductase
AFAEC_a0078	COG3118	belongs to the thioredoxin family