locus-tag	class	description
ASKIR_0001	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
ASKIR_0002	COG0592	DNA-directed DNA polymerase activity
ASKIR_0003	COG0187	DNA topoisomerase II activity
ASKIR_0004	COG0492	ferredoxin-NADP+ reductase activity
ASKIR_0005	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
ASKIR_0009	COG0500	methyltransferase
ASKIR_0010	COG3842	ATPase activity
ASKIR_0018	COG0564	pseudouridine synthase activity
ASKIR_0019	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
ASKIR_0020	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ASKIR_0021	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ASKIR_0023	COG0052	Belongs to the universal ribosomal protein uS2 family
ASKIR_0024	COG0604	alcohol dehydrogenase
ASKIR_0025	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
ASKIR_0026	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
ASKIR_0028	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ASKIR_0028	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ASKIR_0029	COG0511	ligase activity, forming carbon-carbon bonds
ASKIR_0030	COG0439	Biotin carboxylase
ASKIR_0031	COG0513	Belongs to the DEAD box helicase family
ASKIR_0032	COG0306	phosphate transporter
ASKIR_0034	COG0367	asparagine synthase
ASKIR_0036	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
ASKIR_0037	COG1981	membrane
ASKIR_0038	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
ASKIR_0038	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
ASKIR_0039	COG1187	pseudouridine synthase activity
ASKIR_0040	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
ASKIR_0040	COG0517	IMP dehydrogenase activity
ASKIR_0041	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
ASKIR_0042	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
ASKIR_0043	COG0107	imidazoleglycerol-phosphate synthase activity
ASKIR_0046	COG0820	rRNA (adenine-C2-)-methyltransferase activity
ASKIR_0047	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ASKIR_0048	COG0724	RNA recognition motif
ASKIR_0049	COG0745	RESPONSE REGULATOR receiver
ASKIR_0050	COG0642	Histidine kinase
ASKIR_0054	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ASKIR_0056	COG0460	homoserine dehydrogenase
ASKIR_0057	COG0436	Aminotransferase
ASKIR_0059	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ASKIR_0060	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
ASKIR_0061	COG0254	rRNA binding
ASKIR_0062	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
ASKIR_0064	COG0109	protoheme IX farnesyltransferase activity
ASKIR_0066	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
ASKIR_0067	COG4943	cyclic-guanylate-specific phosphodiesterase activity
ASKIR_0068	COG0573	inorganic phosphate transmembrane transporter activity
ASKIR_0069	COG0581	inorganic phosphate transmembrane transporter activity
ASKIR_0070	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
ASKIR_0073	COG0745	RESPONSE REGULATOR receiver
ASKIR_0074	COG5002	protein histidine kinase activity
ASKIR_0075	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
ASKIR_0076	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
ASKIR_0079	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
ASKIR_0082	COG2022	thiamine diphosphate biosynthetic process
ASKIR_0085	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
ASKIR_0086	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
ASKIR_0088	COG0351	phosphomethylpyrimidine kinase
ASKIR_0088	COG0352	thiamine-phosphate diphosphorylase activity
ASKIR_0090	COG0546	phosphoglycolate phosphatase activity
ASKIR_0095	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
ASKIR_0096	COG1854	S-ribosylhomocysteine lyase activity
ASKIR_0100	COG1410	methionine synthase
ASKIR_0100	COG0646	methionine synthase
ASKIR_0105	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
ASKIR_0105	COG0140	phosphoribosyl-ATP diphosphatase activity
ASKIR_0108	COG0456	acetyltransferase
ASKIR_0109	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
ASKIR_0110	COG1917	Cupin 2, conserved barrel domain protein
ASKIR_0113	COG0489	protein tyrosine kinase activity
ASKIR_0115	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
ASKIR_0115	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
ASKIR_0117	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
ASKIR_0119	COG0505	Belongs to the CarA family
ASKIR_0121	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
ASKIR_0122	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
ASKIR_0123	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
ASKIR_0128	COG4895	conserved protein (DUF2196)
ASKIR_0129	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
ASKIR_0130	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
ASKIR_0131	COG0237	dephospho-CoA kinase activity
ASKIR_0133	COG0504	CTP synthase activity
ASKIR_0134	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
ASKIR_0134	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
ASKIR_0137	COG0693	protein deglycase activity
ASKIR_0138	COG0587	DNA-directed DNA polymerase activity
ASKIR_0139	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
ASKIR_0142	COG3040	lipid binding
ASKIR_0146	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
ASKIR_0148	COG2200	EAL domain
ASKIR_0149	COG3279	Response regulator of the LytR AlgR family
ASKIR_0150	COG3275	phosphorelay sensor kinase activity
ASKIR_0151	COG1233	COG1233 Phytoene dehydrogenase and related
ASKIR_0152	COG0415	Belongs to the DNA photolyase family
ASKIR_0155	COG0315	cyclic pyranopterin monophosphate synthase activity
ASKIR_0156	COG0828	Belongs to the bacterial ribosomal protein bS21 family
ASKIR_0157	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
ASKIR_0158	COG0268	Binds directly to 16S ribosomal RNA
ASKIR_0159	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ASKIR_0160	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
ASKIR_0161	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
ASKIR_0162	COG0746	molybdenum cofactor guanylyltransferase activity
ASKIR_0165	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
ASKIR_0166	COG0291	Belongs to the bacterial ribosomal protein bL35 family
ASKIR_0167	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
ASKIR_0168	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
ASKIR_0172	COG0575	Belongs to the CDS family
ASKIR_0173	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
ASKIR_0176	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
ASKIR_0178	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
ASKIR_0178	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
ASKIR_0187	COG0511	ligase activity, forming carbon-carbon bonds
ASKIR_0187	COG5016	pyruvate
ASKIR_0190	COG0840	transmembrane signaling receptor activity
ASKIR_0192	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
ASKIR_0193	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
ASKIR_0195	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
ASKIR_0202	COG0004	ammonium transporteR
ASKIR_0203	COG0347	Belongs to the P(II) protein family
ASKIR_0205	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
ASKIR_0206	COG1706	bacterial-type flagellum-dependent cell motility
ASKIR_0208	COG1987	bacterial-type flagellum assembly
ASKIR_0213	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
ASKIR_0219	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ASKIR_0221	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
ASKIR_0222	COG0601	transmembrane transport
ASKIR_0223	COG0736	holo-[acyl-carrier-protein] synthase activity
ASKIR_0226	COG0786	glutamate:sodium symporter activity
ASKIR_0227	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
ASKIR_0229	COG0560	Phosphoserine phosphatase
ASKIR_0230	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
ASKIR_0231	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
ASKIR_0232	COG3248	Nucleoside-binding outer membrane protein
ASKIR_0233	COG1393	Belongs to the ArsC family
ASKIR_0234	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
ASKIR_0235	COG0343	queuine tRNA-ribosyltransferase activity
ASKIR_0240	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
ASKIR_0241	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
ASKIR_0242	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
ASKIR_0243	COG3278	Belongs to the heme-copper respiratory oxidase family
ASKIR_0254	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
ASKIR_0257	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
ASKIR_0259	COG0157	Belongs to the NadC ModD family
ASKIR_0262	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
ASKIR_0264	COG0083	homoserine kinase activity
ASKIR_0266	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
ASKIR_0267	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
ASKIR_0268	COG0779	Required for maturation of 30S ribosomal subunits
ASKIR_0269	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ASKIR_0269	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ASKIR_0270	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
ASKIR_0271	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ASKIR_0272	COG0539	negative regulation of cytoplasmic translation
ASKIR_0272	COG1185	polyribonucleotide nucleotidyltransferase activity
ASKIR_0273	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
ASKIR_0274	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
ASKIR_0275	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ASKIR_0275	COG0072	phenylalanine-tRNA ligase activity
ASKIR_0276	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
ASKIR_0277	COG0537	adenosine 5'-monophosphoramidase activity
ASKIR_0279	COG0825	malonyl-CoA metabolic process
ASKIR_0280	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ASKIR_0281	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ASKIR_0283	COG0602	queuosine metabolic process
ASKIR_0285	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
ASKIR_0287	COG1385	rRNA (uridine-N3-)-methyltransferase activity
ASKIR_0290	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
ASKIR_0291	COG0723	plastoquinol--plastocyanin reductase activity
ASKIR_0292	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
ASKIR_0293	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
ASKIR_0294	COG0210	DNA helicase
ASKIR_0295	COG0356	it plays a direct role in the translocation of protons across the membrane
ASKIR_0296	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
ASKIR_0297	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
ASKIR_0299	COG0336	Belongs to the RNA methyltransferase TrmD family
ASKIR_0300	COG0335	large ribosomal subunit rRNA binding
ASKIR_0301	COG0586	Pfam SNARE associated Golgi protein
ASKIR_0302	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ASKIR_0305	COG0251	oxidation-reduction process
ASKIR_0308	COG2183	response to ionizing radiation
ASKIR_0313	COG0540	Belongs to the ATCase OTCase family
ASKIR_0314	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
ASKIR_0315	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ASKIR_0316	COG2824	Alkylphosphonate utilization operon protein PhnA
ASKIR_0318	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ASKIR_0319	COG2205	protein histidine kinase activity
ASKIR_0320	COG0745	RESPONSE REGULATOR receiver
ASKIR_0321	COG0628	permease
ASKIR_0324	COG0659	secondary active sulfate transmembrane transporter activity
ASKIR_0329	COG4771	TonB-dependent receptor
ASKIR_0331	COG1971	Probably functions as a manganese efflux pump
ASKIR_0335	COG2375	cellular response to nickel ion
ASKIR_0335	COG1132	(ABC) transporter
ASKIR_0336	COG4771	TonB-dependent receptor
ASKIR_0340	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
ASKIR_0344	COG3043	anaerobic respiration
ASKIR_0345	COG0348	domain, Protein
ASKIR_0346	COG0437	4 iron, 4 sulfur cluster binding
ASKIR_0347	COG0243	molybdopterin cofactor binding
ASKIR_0350	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
ASKIR_0351	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
ASKIR_0353	COG2404	hydrolase activity, acting on ester bonds
ASKIR_0355	COG0642	Histidine kinase
ASKIR_0356	COG0745	RESPONSE REGULATOR receiver
ASKIR_0357	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ASKIR_0358	COG0191	fructose-bisphosphate aldolase activity
ASKIR_0359	COG0039	L-malate dehydrogenase activity
ASKIR_0362	COG0848	biopolymer transport protein
ASKIR_0363	COG0811	peptide transport
ASKIR_0365	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
ASKIR_0366	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
ASKIR_0369	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
ASKIR_0370	COG0442	prolyl-tRNA aminoacylation
ASKIR_0371	COG0668	transmembrane transport
ASKIR_0372	COG0617	tRNA 3'-terminal CCA addition
ASKIR_0375	COG0815	Transfers the fatty acyl group on membrane lipoproteins
ASKIR_0376	COG1862	Preprotein translocase
ASKIR_0377	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ASKIR_0378	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ASKIR_0381	COG1360	Flagellar Motor Protein
ASKIR_0382	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
ASKIR_0384	COG0495	leucyl-tRNA aminoacylation
ASKIR_0386	COG0285	dihydrofolate synthase activity
ASKIR_0392	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
ASKIR_0397	COG0077	Prephenate dehydratase
ASKIR_0397	COG1605	Chorismate mutase
ASKIR_0407	COG0745	RESPONSE REGULATOR receiver
ASKIR_0408	COG0642	Histidine kinase
ASKIR_0409	COG2081	HI0933 family
ASKIR_0410	COG0840	transmembrane signaling receptor activity
ASKIR_0413	COG5002	protein histidine kinase activity
ASKIR_0414	COG1692	metallophosphoesterase
ASKIR_0418	COG1570	exodeoxyribonuclease VII activity
ASKIR_0419	COG0835	chemotaxis
ASKIR_0420	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
ASKIR_0421	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
ASKIR_0422	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
ASKIR_0425	COG0459	protein refolding
ASKIR_0427	COG0745	RESPONSE REGULATOR receiver
ASKIR_0428	COG5002	protein histidine kinase activity
ASKIR_0430	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
ASKIR_0432	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
ASKIR_0433	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
ASKIR_0435	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
ASKIR_0437	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ASKIR_0438	COG2264	protein methyltransferase activity
ASKIR_0439	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ASKIR_0440	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ASKIR_0443	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
ASKIR_0445	COG2095	MarC family integral membrane protein
ASKIR_0449	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
ASKIR_0449	COG1648	precorrin-2 dehydrogenase activity
ASKIR_0451	COG1648	precorrin-2 dehydrogenase activity
ASKIR_0451	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
ASKIR_0452	COG2078	PFAM AMMECR1 domain protein
ASKIR_0453	COG1355	regulation of microtubule-based process
ASKIR_0454	COG0840	transmembrane signaling receptor activity
ASKIR_0455	COG1434	Gram-negative-bacterium-type cell wall biogenesis
ASKIR_0456	COG1121	(ABC) transporter
ASKIR_0457	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ASKIR_0458	COG2996	Protein conserved in bacteria
ASKIR_0459	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
ASKIR_0461	COG0210	DNA helicase
ASKIR_0462	COG0569	domain protein
ASKIR_0462	COG0475	glutathione-regulated potassium exporter activity
ASKIR_0463	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
ASKIR_0475	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
ASKIR_0476	COG4608	Belongs to the ABC transporter superfamily
ASKIR_0477	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
ASKIR_0478	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ASKIR_0484	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
ASKIR_0485	COG0267	Belongs to the bacterial ribosomal protein bL33 family
ASKIR_0488	COG0250	Participates in transcription elongation, termination and antitermination
ASKIR_0489	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
ASKIR_0490	COG0081	regulation of translation
ASKIR_0491	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
ASKIR_0492	COG0222	ribosome binding
ASKIR_0493	COG0085	RNA polymerase activity
ASKIR_0494	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
ASKIR_0498	COG0741	lytic transglycosylase activity
ASKIR_0498	COG1196	nuclear chromosome segregation
ASKIR_0498	COG0739	heme binding
ASKIR_0500	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
ASKIR_0501	COG0138	bifunctional purine biosynthesis protein purh
ASKIR_0503	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
ASKIR_0506	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ASKIR_0508	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ASKIR_0511	COG2326	polyphosphate kinase activity
ASKIR_0512	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
ASKIR_0513	COG0571	ribonuclease III activity
ASKIR_0515	COG0358	DNA primase activity
ASKIR_0516	COG0261	This protein binds to 23S rRNA in the presence of protein L20
ASKIR_0517	COG0211	Belongs to the bacterial ribosomal protein bL27 family
ASKIR_0518	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
ASKIR_0519	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
ASKIR_0520	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
ASKIR_0522	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
ASKIR_0522	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
ASKIR_0523	COG1192	Involved in chromosome partitioning
ASKIR_0524	COG1475	DNA binding
ASKIR_0526	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
ASKIR_0527	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
ASKIR_0528	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
ASKIR_0529	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
ASKIR_0530	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
ASKIR_0531	COG0355	proton-transporting ATP synthase activity, rotational mechanism
ASKIR_0532	COG0811	peptide transport
ASKIR_0533	COG0848	biopolymer transport protein
ASKIR_0535	COG0823	Involved in the tonB-independent uptake of proteins
ASKIR_0538	COG1047	Peptidyl-prolyl cis-trans
ASKIR_0539	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
ASKIR_0540	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
ASKIR_0541	COG1027	Aspartate ammonia-lyase
ASKIR_0546	COG1227	inorganic diphosphatase activity
ASKIR_0547	COG0668	transmembrane transport
ASKIR_0548	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
ASKIR_0550	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ASKIR_0551	COG0010	Belongs to the arginase family
ASKIR_0553	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
ASKIR_0554	COG1278	Cold shock
ASKIR_0555	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
ASKIR_0556	COG0581	inorganic phosphate transmembrane transporter activity
ASKIR_0557	COG0573	inorganic phosphate transmembrane transporter activity
ASKIR_0558	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
ASKIR_0559	COG4335	DNA alkylation repair
ASKIR_0560	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
ASKIR_0564	COG0753	catalase activity
ASKIR_0569	COG4753	response regulator
ASKIR_0569	COG2207	Transcriptional regulator
ASKIR_0570	COG4191	Histidine kinase
ASKIR_0571	COG0348	domain, Protein
ASKIR_0572	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
ASKIR_0574	COG0840	transmembrane signaling receptor activity
ASKIR_0575	COG0840	transmembrane signaling receptor activity
ASKIR_0576	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
ASKIR_0577	COG0750	zinc metalloprotease
ASKIR_0578	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
ASKIR_0579	COG1028	Short-chain dehydrogenase reductase Sdr
ASKIR_0580	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ASKIR_0582	COG0167	dihydroorotate dehydrogenase activity
ASKIR_0583	COG1132	(ABC) transporter
ASKIR_0584	COG0728	peptidoglycan biosynthetic process
ASKIR_0587	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
ASKIR_0589	COG0789	Transcriptional regulator
ASKIR_0590	COG0484	heat shock protein binding
ASKIR_0595	COG0326	Molecular chaperone. Has ATPase activity
ASKIR_0597	COG0513	Belongs to the DEAD box helicase family
ASKIR_0600	COG0259	pyridoxamine-phosphate oxidase activity
ASKIR_0603	COG3287	FIST C domain
ASKIR_0603	COG2200	EAL domain
ASKIR_0603	COG2199	diguanylate cyclase activity
ASKIR_0616	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
ASKIR_0617	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ASKIR_0617	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ASKIR_0620	COG1090	epimerase
ASKIR_0621	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
ASKIR_0627	COG0730	response to heat
ASKIR_0628	COG1045	serine acetyltransferase
ASKIR_0629	COG1166	arginine decarboxylase activity
ASKIR_0630	COG0124	histidyl-tRNA synthetase
ASKIR_0631	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
ASKIR_0632	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
ASKIR_0633	COG0163	prenyltransferase activity
ASKIR_0635	COG0359	binds to the 23S rRNA
ASKIR_0636	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
ASKIR_0637	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
ASKIR_0639	COG0084	hydrolase, TatD family'
ASKIR_0640	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
ASKIR_0641	COG0131	Imidazoleglycerol-phosphate dehydratase
ASKIR_0642	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
ASKIR_0645	COG0218	Necessary for normal cell division and for the maintenance of normal septation
ASKIR_0646	COG0456	acetyltransferase
ASKIR_0647	COG0051	transcription antitermination factor activity, RNA binding
ASKIR_0648	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
ASKIR_0649	COG0088	Forms part of the polypeptide exit tunnel
ASKIR_0650	COG0089	rRNA binding
ASKIR_0651	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
ASKIR_0652	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
ASKIR_0653	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
ASKIR_0654	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
ASKIR_0655	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
ASKIR_0656	COG0255	Belongs to the universal ribosomal protein uL29 family
ASKIR_0657	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
ASKIR_0658	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
ASKIR_0659	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
ASKIR_0660	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
ASKIR_0661	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
ASKIR_0662	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
ASKIR_0663	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
ASKIR_0664	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
ASKIR_0665	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
ASKIR_0666	COG0200	Binds to the 23S rRNA
ASKIR_0667	COG0201	protein transport
ASKIR_0668	COG0024	Methionine aminopeptidase
ASKIR_0669	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
ASKIR_0670	COG1573	uracil-dna glycosylase
ASKIR_0672	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
ASKIR_0673	COG1032	radical SAM domain protein
ASKIR_0674	COG0563	adenylate kinase activity
ASKIR_0675	COG0563	adenylate kinase activity
ASKIR_0680	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
ASKIR_0681	COG0840	transmembrane signaling receptor activity
ASKIR_0682	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
ASKIR_0683	COG0322	excinuclease ABC activity
ASKIR_0686	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ASKIR_0688	COG3437	response regulator, receiver
ASKIR_0688	COG0784	Response regulator, receiver
ASKIR_0689	COG1338	Plays a role in the flagellum-specific transport system
ASKIR_0690	COG0768	penicillin binding
ASKIR_0694	COG2884	Cell division ATP-binding protein ftsE
ASKIR_0695	COG0220	tRNA (guanine-N7-)-methyltransferase activity
ASKIR_0697	COG0564	pseudouridine synthase activity
ASKIR_0698	COG0772	Belongs to the SEDS family
ASKIR_0700	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
ASKIR_0701	COG3123	guanosine phosphorylase activity
ASKIR_0705	COG1278	Cold shock
ASKIR_0707	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
ASKIR_0708	COG0066	3-isopropylmalate dehydratase activity
ASKIR_0709	COG0473	3-isopropylmalate dehydrogenase activity
ASKIR_0712	COG0257	Belongs to the bacterial ribosomal protein bL36 family
ASKIR_0713	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
ASKIR_0714	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
ASKIR_0715	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
ASKIR_0716	COG0202	RNA polymerase activity
ASKIR_0717	COG0203	ribosomal protein L17
ASKIR_0718	COG0154	amidase activity
ASKIR_0719	COG0516	GMP reductase activity
ASKIR_0719	COG0517	IMP dehydrogenase activity
ASKIR_0722	COG0484	heat shock protein binding
ASKIR_0723	COG0484	heat shock protein binding
ASKIR_0725	COG0513	Belongs to the DEAD box helicase family
ASKIR_0726	COG2217	Heavy metal translocating P-type atpase
ASKIR_0728	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ASKIR_0729	COG0508	dehydrogenase complex catalyzes the overall conversion of
ASKIR_0730	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
ASKIR_0731	COG0095	Lipoate-protein ligase
ASKIR_0732	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
ASKIR_0733	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ASKIR_0734	COG0840	transmembrane signaling receptor activity
ASKIR_0735	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
ASKIR_0736	COG1944	ATP diphosphatase activity
ASKIR_0737	COG2258	MOSC domain
ASKIR_0738	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ASKIR_0740	COG3135	benzoate transporter
ASKIR_0741	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
ASKIR_0741	COG2169	Transcriptional regulator
ASKIR_0742	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
ASKIR_0747	COG4536	flavin adenine dinucleotide binding
ASKIR_0748	COG0628	permease
ASKIR_0751	COG4974	Belongs to the 'phage' integrase family
ASKIR_0785	COG0653	protein targeting
ASKIR_0788	COG3328	transposase activity
ASKIR_0814	COG3179	chitinase
ASKIR_0818	COG3179	chitinase
ASKIR_0823	COG0420	3'-5' exonuclease activity
ASKIR_0824	COG0419	ATPase involved in DNA repair
ASKIR_0829	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
ASKIR_0843	COG0284	orotidine-5'-phosphate decarboxylase activity
ASKIR_0844	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ASKIR_0845	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
ASKIR_0847	COG2877	3-deoxy-8-phosphooctulonate synthase activity
ASKIR_0849	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
ASKIR_0851	COG1295	ribonuclease BN
ASKIR_0852	COG0277	FAD linked oxidase domain protein
ASKIR_0854	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
ASKIR_0855	COG2226	methyltransferase
ASKIR_0861	COG1739	Uncharacterized protein family UPF0029
ASKIR_0865	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ASKIR_0865	COG0301	tRNA thio-modification
ASKIR_0868	COG2814	Major facilitator Superfamily
ASKIR_0883	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
ASKIR_0889	COG0330	HflC and HflK could
ASKIR_0894	COG2081	HI0933 family
ASKIR_0900	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
ASKIR_0901	COG2171	N-acyltransferase activity
ASKIR_0902	COG0488	(ABC) transporter
ASKIR_0917	COG1137	ATPase activity
ASKIR_0919	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
ASKIR_0920	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
ASKIR_0921	COG0137	argininosuccinate synthase activity
ASKIR_0924	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
ASKIR_0926	COG0776	regulation of translation
ASKIR_0927	COG0708	Exodeoxyribonuclease III
ASKIR_0933	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
ASKIR_0935	COG2204	response regulator
ASKIR_0937	COG0166	Belongs to the GPI family
ASKIR_0945	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
ASKIR_0951	COG1858	cytochrome C peroxidase
ASKIR_0953	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
ASKIR_0955	COG1921	L-seryl-tRNASec selenium transferase activity
ASKIR_0960	COG0450	alkyl hydroperoxide reductase
ASKIR_0961	COG0840	transmembrane signaling receptor activity
ASKIR_0962	COG0840	transmembrane signaling receptor activity
ASKIR_0963	COG0709	Synthesizes selenophosphate from selenide and ATP
ASKIR_0964	COG1305	Transglutaminase-like
ASKIR_0968	COG2204	response regulator
ASKIR_0975	COG0437	4 iron, 4 sulfur cluster binding
ASKIR_0977	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
ASKIR_0981	COG0303	'Molybdopterin
ASKIR_0982	COG2998	abc-type tungstate transport system, permease component
ASKIR_0983	COG4662	Binding-protein-dependent transport system inner membrane component
ASKIR_0986	COG0446	pyridine nucleotide-disulphide oxidoreductase
ASKIR_0989	COG1132	(ABC) transporter
ASKIR_0991	COG0596	Alpha beta hydrolase
ASKIR_0996	COG0518	GMP synthase (glutamine-hydrolyzing) activity
ASKIR_0996	COG0519	Catalyzes the synthesis of GMP from XMP
ASKIR_0997	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
ASKIR_1000	COG0436	Aminotransferase
ASKIR_1003	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
ASKIR_1004	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
ASKIR_1004	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
ASKIR_1008	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ASKIR_1009	COG1611	Belongs to the LOG family
ASKIR_1013	COG0739	heme binding
ASKIR_1014	COG0217	transcriptional regulatory protein
ASKIR_1018	COG0428	transporter
ASKIR_1019	COG1049	propionate catabolic process, 2-methylcitrate cycle
ASKIR_1020	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
ASKIR_1020	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ASKIR_1029	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
ASKIR_1030	COG0511	ligase activity, forming carbon-carbon bonds
ASKIR_1030	COG5016	pyruvate
ASKIR_1034	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ASKIR_1034	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ASKIR_1036	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
ASKIR_1041	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ASKIR_1042	COG0612	Peptidase, M16
ASKIR_1043	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
ASKIR_1044	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ASKIR_1045	COG0287	Prephenate dehydrogenase
ASKIR_1046	COG0386	Belongs to the glutathione peroxidase family
ASKIR_1047	COG4221	oxidoreductase activity
ASKIR_1052	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
ASKIR_1054	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
ASKIR_1057	COG0527	aspartate kinase activity
ASKIR_1058	COG0494	nUDIX hydrolase
ASKIR_1059	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ASKIR_1060	COG2890	protein-(glutamine-N5) methyltransferase activity
ASKIR_1061	COG0339	signal peptide processing
ASKIR_1064	COG0582	viral genome integration into host DNA
ASKIR_1065	COG2201	protein-glutamate methylesterase activity
ASKIR_1068	COG0643	Histidine kinase
ASKIR_1068	COG2198	Histidine kinase
ASKIR_1069	COG0745	RESPONSE REGULATOR receiver
ASKIR_1070	COG1185	polyribonucleotide nucleotidyltransferase activity
ASKIR_1076	COG1160	GTP binding
ASKIR_1077	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
ASKIR_1079	COG1028	Short-chain dehydrogenase reductase Sdr
ASKIR_1080	COG1674	ftsk spoiiie
ASKIR_1080	COG1196	nuclear chromosome segregation
ASKIR_1081	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ASKIR_1082	COG0440	acetolactate synthase activity
ASKIR_1083	COG0028	Belongs to the TPP enzyme family
ASKIR_1085	COG0248	Ppx GppA phosphatase
ASKIR_1090	COG0037	tRNA processing
ASKIR_1094	COG0501	Belongs to the peptidase M48B family
ASKIR_1095	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ASKIR_1096	COG0824	Thioesterase
ASKIR_1098	COG1663	tetraacyldisaccharide 4'-kinase activity
ASKIR_1099	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
ASKIR_1100	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
ASKIR_1104	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ASKIR_1105	COG0805	protein transport
ASKIR_1106	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
ASKIR_1114	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
ASKIR_1117	COG0840	transmembrane signaling receptor activity
ASKIR_1122	COG0357	Ribosomal RNA small subunit methyltransferase G
ASKIR_1123	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ASKIR_1124	COG0113	porphobilinogen synthase activity
ASKIR_1127	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
ASKIR_1128	COG2337	Toxic component of a toxin-antitoxin (TA) module
ASKIR_1130	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
ASKIR_1131	COG1396	sequence-specific DNA binding
ASKIR_1134	COG1216	Glycosyl transferase, family 2
ASKIR_1134	COG0463	Glycosyl transferase, family 2
ASKIR_1136	COG0110	maltose O-acetyltransferase activity
ASKIR_1138	COG2244	polysaccharide biosynthetic process
ASKIR_1144	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ASKIR_1162	COG0667	Aldo Keto reductase
ASKIR_1167	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
ASKIR_1168	COG0484	heat shock protein binding
ASKIR_1170	COG2111	Na H antiporter
ASKIR_1170	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
ASKIR_1171	COG1006	Multisubunit Na H antiporter MnhC subunit
ASKIR_1172	COG0651	ATP synthesis coupled electron transport
ASKIR_1173	COG1863	multisubunit Na H antiporter MnhE subunit
ASKIR_1174	COG2212	antiporter activity
ASKIR_1175	COG1320	monovalent cation:proton antiporter activity
ASKIR_1177	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ASKIR_1179	COG0500	methyltransferase
ASKIR_1180	COG2195	Cleaves the N-terminal amino acid of tripeptides
ASKIR_1181	COG1333	cytochrome c biogenesis protein
ASKIR_1181	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ASKIR_1183	COG0135	phosphoribosylanthranilate isomerase activity
ASKIR_1184	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
ASKIR_1188	COG1666	GTP binding
ASKIR_1189	COG2363	Small membrane protein
ASKIR_1190	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
ASKIR_1191	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
ASKIR_1192	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ASKIR_1195	COG1119	ATPase activity
ASKIR_1197	COG1253	flavin adenine dinucleotide binding
ASKIR_1198	COG1193	negative regulation of DNA recombination
ASKIR_1199	COG0521	Mo-molybdopterin cofactor biosynthetic process
ASKIR_1201	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ASKIR_1202	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ASKIR_1204	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
ASKIR_1206	COG4139	cobalamin transport
ASKIR_1208	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ASKIR_1212	COG0546	phosphoglycolate phosphatase activity
ASKIR_1213	COG1187	pseudouridine synthase activity
ASKIR_1214	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
ASKIR_1220	COG0328	RNA-DNA hybrid ribonuclease activity
ASKIR_1221	COG0488	(ABC) transporter
ASKIR_1223	COG0739	heme binding
ASKIR_1225	COG0134	indole-3-glycerol-phosphate synthase activity
ASKIR_1227	COG0727	PFAM Uncharacterised protein family (UPF0153)
ASKIR_1228	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
ASKIR_1230	COG0674	pyruvate-flavodoxin oxidoreductase activity
ASKIR_1230	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
ASKIR_1231	COG1013	pyruvate-flavodoxin oxidoreductase activity
ASKIR_1235	COG0653	protein targeting
ASKIR_1236	COG4591	ABC-type transport system involved in lipoprotein release permease component
ASKIR_1244	COG0275	rRNA processing
ASKIR_1246	COG0776	regulation of translation
ASKIR_1249	COG0300	oxidoreductase activity
ASKIR_1253	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ASKIR_1254	COG0742	ribosomal rna small subunit methyltransferase
ASKIR_1255	COG1418	mRNA catabolic process
ASKIR_1258	COG0552	protein localization to endoplasmic reticulum
ASKIR_1261	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
ASKIR_1262	COG0861	Integral membrane protein TerC family
ASKIR_1263	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
ASKIR_1265	COG5002	protein histidine kinase activity
ASKIR_1266	COG0745	RESPONSE REGULATOR receiver
ASKIR_1268	COG1283	sodium-dependent phosphate transmembrane transporter activity
ASKIR_1270	COG1114	Component of the transport system for branched-chain amino acids
ASKIR_1271	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
ASKIR_1272	COG0788	formyltetrahydrofolate deformylase activity
ASKIR_1273	COG0280	phosphate acetyltransferase
ASKIR_1273	COG0281	malic enzyme
ASKIR_1274	COG1496	oxidoreductase activity
ASKIR_1275	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
ASKIR_1276	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
ASKIR_1278	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
ASKIR_1280	COG0514	ATP-dependent DNA helicase (RecQ)
ASKIR_1281	COG0582	viral genome integration into host DNA
ASKIR_1309	COG0629	single-stranded DNA binding
ASKIR_1312	COG3451	type IV secretory pathway VirB4
ASKIR_1319	COG2948	multi-organism process
ASKIR_1321	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
ASKIR_1326	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
ASKIR_1327	COG1722	exodeoxyribonuclease VII activity
ASKIR_1328	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
ASKIR_1330	COG2391	methyltransferase activity
ASKIR_1332	COG0849	cell division
ASKIR_1334	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
ASKIR_1336	COG0513	Belongs to the DEAD box helicase family
ASKIR_1338	COG0754	glutathionylspermidine amidase activity
ASKIR_1339	COG1607	acyl-coa hydrolase
ASKIR_1340	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
ASKIR_1342	COG1136	(ABC) transporter
ASKIR_1342	COG0577	efflux transmembrane transporter activity
ASKIR_1343	COG1136	(ABC) transporter
ASKIR_1343	COG0577	efflux transmembrane transporter activity
ASKIR_1344	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ASKIR_1347	COG0848	biopolymer transport protein
ASKIR_1349	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
ASKIR_1351	COG0133	tryptophan synthase activity
ASKIR_1352	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
ASKIR_1353	COG1793	dna ligase
ASKIR_1354	COG0626	cystathionine gamma-synthase activity
ASKIR_1360	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
ASKIR_1361	COG0803	Belongs to the bacterial solute-binding protein 9 family
ASKIR_1363	COG0528	UMP kinase activity
ASKIR_1364	COG1758	RNA polymerase activity
ASKIR_1366	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
ASKIR_1368	COG0860	N-Acetylmuramoyl-L-alanine amidase
ASKIR_1371	COG0193	aminoacyl-tRNA hydrolase activity
ASKIR_1372	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
ASKIR_1373	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
ASKIR_1374	COG0681	Belongs to the peptidase S26 family
ASKIR_1375	COG0698	ribose 5-phosphate isomerase
ASKIR_1378	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
ASKIR_1379	COG2198	Histidine kinase
ASKIR_1379	COG5002	protein histidine kinase activity
ASKIR_1379	COG0784	Response regulator, receiver
ASKIR_1380	COG2203	Gaf domain
ASKIR_1380	COG3706	GGDEF domain
ASKIR_1380	COG4251	negative regulation of phosphorylation
ASKIR_1380	COG5001	Diguanylate cyclase
ASKIR_1381	COG0556	nucleotide-excision repair
ASKIR_1383	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ASKIR_1384	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
ASKIR_1385	COG0784	Response regulator, receiver
ASKIR_1385	COG0835	chemotaxis
ASKIR_1386	COG0165	Argininosuccinate lyase
ASKIR_1388	COG2239	Acts as a magnesium transporter
ASKIR_1390	COG0719	Fe-S assembly protein
ASKIR_1391	COG0396	ATPase activity
ASKIR_1392	COG0719	Fe-S assembly protein
ASKIR_1393	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
ASKIR_1394	COG2166	iron-sulfur cluster assembly
ASKIR_1399	COG4773	Receptor
ASKIR_1400	COG0439	Biotin carboxylase
ASKIR_1402	COG3077	Addiction module antitoxin, RelB DinJ family
ASKIR_1408	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
ASKIR_1410	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
ASKIR_1414	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
ASKIR_1415	COG2814	Major facilitator Superfamily
ASKIR_1418	COG0525	valine-tRNA ligase activity
ASKIR_1422	COG0174	glutamine synthetase
ASKIR_1424	COG0314	molybdopterin synthase activity
ASKIR_1426	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
ASKIR_1427	COG1968	undecaprenyl-diphosphatase activity
ASKIR_1429	COG1373	ATPase (AAA superfamily
ASKIR_1430	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
ASKIR_1431	COG0772	Belongs to the SEDS family
ASKIR_1432	COG0768	penicillin binding
ASKIR_1433	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
ASKIR_1442	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
ASKIR_1444	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
ASKIR_1447	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
ASKIR_1449	COG0227	Belongs to the bacterial ribosomal protein bL28 family
ASKIR_1451	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
ASKIR_1453	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
ASKIR_1453	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
ASKIR_1454	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
ASKIR_1456	COG1368	sulfuric ester hydrolase activity
ASKIR_1460	COG0463	Glycosyl transferase, family 2
ASKIR_1467	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
ASKIR_1469	COG0859	PFAM glycosyl transferase family 9
ASKIR_1471	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
ASKIR_1472	COG0483	inositol monophosphate 1-phosphatase activity
ASKIR_1477	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
ASKIR_1479	COG1181	Belongs to the D-alanine--D-alanine ligase family
ASKIR_1480	COG0632	four-way junction helicase activity
ASKIR_1481	COG0840	transmembrane signaling receptor activity
ASKIR_1483	COG0585	pseudouridine synthase activity
ASKIR_1484	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
ASKIR_1485	COG3123	guanosine phosphorylase activity
ASKIR_1488	COG1639	'signal transduction protein
ASKIR_1489	COG0012	GTP binding
ASKIR_1490	COG1966	Carbon starvation protein
ASKIR_1495	COG0305	Participates in initiation and elongation during chromosome replication
ASKIR_1496	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
ASKIR_1499	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
ASKIR_1500	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
ASKIR_1502	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
ASKIR_1503	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
ASKIR_1504	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
ASKIR_1506	COG3706	GGDEF domain
ASKIR_1507	COG0501	Belongs to the peptidase M48B family
ASKIR_1510	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
ASKIR_1512	COG0706	membrane insertase activity
ASKIR_1513	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
ASKIR_1515	COG0230	Belongs to the bacterial ribosomal protein bL34 family
ASKIR_1516	COG0542	response to heat
ASKIR_1532	COG3210	domain, Protein
ASKIR_1532	COG3210	domain, Protein
ASKIR_1533	COG2831	hemolysin activation secretion protein
ASKIR_1534	COG0488	(ABC) transporter
ASKIR_1536	COG0778	Nitroreductase
ASKIR_1537	COG2249	NAD(P)H dehydrogenase (quinone) activity
ASKIR_1543	COG2855	membrane
ASKIR_1544	COG0583	DNA-binding transcription factor activity
ASKIR_1546	COG2076	Multidrug Resistance protein
ASKIR_1547	COG0642	Histidine kinase
ASKIR_1550	COG3258	Cytochrome c
ASKIR_1559	COG0628	permease
ASKIR_1560	COG2255	four-way junction helicase activity
ASKIR_1561	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
ASKIR_1562	COG0159	tryptophan synthase activity
ASKIR_1563	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
ASKIR_1564	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
ASKIR_1569	COG0598	Magnesium transport protein CorA
ASKIR_1570	COG1459	type II secretion system
ASKIR_1571	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ASKIR_1574	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
ASKIR_1575	COG0606	chelatase, subunit chli
ASKIR_1576	COG0840	transmembrane signaling receptor activity
ASKIR_1577	COG0840	transmembrane signaling receptor activity
ASKIR_1579	COG0242	peptide deformylase activity
ASKIR_1580	COG0740	serine-type endopeptidase activity
ASKIR_1581	COG0544	peptidyl-prolyl cis-trans isomerase activity
ASKIR_1582	COG2326	polyphosphate kinase activity
ASKIR_1594	COG0542	response to heat
ASKIR_1595	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
ASKIR_1596	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
ASKIR_1599	COG2030	dehydratase
ASKIR_1607	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
ASKIR_1609	COG0481	GTPase activity
ASKIR_1610	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
ASKIR_1611	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
ASKIR_1612	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
ASKIR_1613	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
ASKIR_1617	COG2217	Heavy metal translocating P-type atpase
ASKIR_1618	COG4943	cyclic-guanylate-specific phosphodiesterase activity
ASKIR_1619	COG0194	GDP metabolic process
ASKIR_1621	COG1136	(ABC) transporter
ASKIR_1622	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
ASKIR_1623	COG0052	Belongs to the universal ribosomal protein uS2 family
ASKIR_1624	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
ASKIR_1628	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
ASKIR_1629	COG0579	oxidoreductase
ASKIR_1639	COG0642	Histidine kinase
ASKIR_1640	COG0745	RESPONSE REGULATOR receiver
ASKIR_1643	COG2176	DNA-directed DNA polymerase activity
ASKIR_1645	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ASKIR_1649	COG2176	DNA-directed DNA polymerase activity
ASKIR_1651	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
ASKIR_1652	COG0280	phosphate acetyltransferase
ASKIR_1653	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
ASKIR_1654	COG0616	signal peptide processing
ASKIR_1655	COG0402	S-adenosylhomocysteine deaminase activity
ASKIR_1656	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
ASKIR_1657	COG0006	proline dipeptidase activity
ASKIR_1658	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
ASKIR_1659	COG0482	sulfurtransferase activity
ASKIR_1660	COG0482	sulfurtransferase activity
ASKIR_1661	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
ASKIR_1663	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
ASKIR_1665	COG1157	protein secretion by the type III secretion system
ASKIR_1667	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
ASKIR_1673	COG0455	bacterial-type flagellum organization
ASKIR_1674	COG1419	protein localization to endoplasmic reticulum
ASKIR_1677	COG3951	Flagellar rod assembly protein muramidase FlgJ
ASKIR_1685	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
ASKIR_1687	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
ASKIR_1688	COG1766	The M ring may be actively involved in energy transduction
ASKIR_1689	COG1815	bacterial-type flagellum-dependent cell motility
ASKIR_1690	COG4786	Flagellar basal body rod
ASKIR_1692	COG0745	RESPONSE REGULATOR receiver
ASKIR_1693	COG4786	Flagellar basal body rod
ASKIR_1696	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
ASKIR_1698	COG0228	four-way junction DNA binding
ASKIR_1699	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
ASKIR_1700	COG0564	pseudouridine synthase activity
ASKIR_1701	COG0220	tRNA (guanine-N7-)-methyltransferase activity
ASKIR_1701	COG1519	Transferase
ASKIR_1703	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
ASKIR_1704	COG0752	glycyl-tRNA synthetase alpha subunit
ASKIR_1706	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
ASKIR_1708	COG0826	peptidase U32
ASKIR_1709	COG0840	transmembrane signaling receptor activity
ASKIR_1710	COG0497	DNA recombination
ASKIR_1711	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
ASKIR_1712	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
ASKIR_1713	COG0049	tRNA binding
ASKIR_1714	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
ASKIR_1718	COG1840	ABC-type Fe3 transport system, periplasmic component
ASKIR_1720	COG3842	ATPase activity
ASKIR_1721	COG1393	Belongs to the ArsC family
ASKIR_1722	COG1335	isochorismatase
ASKIR_1723	COG0181	hydroxymethylbilane synthase activity
ASKIR_1724	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
ASKIR_1725	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
ASKIR_1726	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
ASKIR_1727	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
ASKIR_1728	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
ASKIR_1729	COG0450	alkyl hydroperoxide reductase
ASKIR_1731	COG0105	UTP biosynthetic process
ASKIR_1733	COG0333	Belongs to the bacterial ribosomal protein bL32 family
ASKIR_1734	COG0416	fatty acid biosynthetic process
ASKIR_1735	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ASKIR_1739	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
ASKIR_1740	COG1053	succinate dehydrogenase
ASKIR_1742	COG1007	ATP synthesis coupled electron transport
ASKIR_1744	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
ASKIR_1745	COG0713	ATP synthesis coupled electron transport
ASKIR_1746	COG0839	Belongs to the complex I subunit 6 family
ASKIR_1747	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ASKIR_1748	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
ASKIR_1749	COG1034	ATP synthesis coupled electron transport
ASKIR_1750	COG0372	Belongs to the citrate synthase family
ASKIR_1752	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
ASKIR_1753	COG0649	NAD binding
ASKIR_1753	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ASKIR_1754	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ASKIR_1755	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ASKIR_1756	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
ASKIR_1757	COG0840	transmembrane signaling receptor activity
ASKIR_1759	COG0840	transmembrane signaling receptor activity
ASKIR_1760	COG2199	diguanylate cyclase activity
ASKIR_1760	COG2200	EAL domain
ASKIR_1760	COG3287	FIST C domain
ASKIR_1762	COG3610	response to peptide
ASKIR_1763	COG3610	response to peptide
ASKIR_1765	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
ASKIR_1766	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
ASKIR_1768	COG0840	transmembrane signaling receptor activity
ASKIR_1773	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ASKIR_1775	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
ASKIR_1777	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
ASKIR_1778	COG2828	Protein conserved in bacteria
ASKIR_1779	COG0741	lytic transglycosylase activity
ASKIR_1780	COG0469	pyruvate kinase activity
ASKIR_1782	COG0792	nuclease activity
ASKIR_1783	COG0156	8-amino-7-oxononanoate synthase activity
ASKIR_1784	COG0288	reversible hydration of carbon dioxide
ASKIR_1786	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
ASKIR_1788	COG2121	Domain of unknown function (DUF374)
ASKIR_1789	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ASKIR_1791	COG0195	Participates in both transcription termination and antitermination
ASKIR_1792	COG0215	cysteine-tRNA ligase activity
ASKIR_1793	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
ASKIR_1794	COG0629	single-stranded DNA binding
ASKIR_1795	COG0360	Binds together with S18 to 16S ribosomal RNA
ASKIR_1798	COG0557	exoribonuclease II activity
ASKIR_1799	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
ASKIR_1802	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
ASKIR_1803	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
ASKIR_1804	COG0492	ferredoxin-NADP+ reductase activity
ASKIR_1805	COG3118	belongs to the thioredoxin family
ASKIR_1806	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
ASKIR_1808	COG4771	TonB-dependent receptor
ASKIR_1809	COG0642	Histidine kinase
ASKIR_1810	COG0745	RESPONSE REGULATOR receiver
ASKIR_1812	COG0129	dihydroxy-acid dehydratase activity
ASKIR_1816	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
ASKIR_1817	COG0585	pseudouridine synthase activity
ASKIR_1820	COG0793	Belongs to the peptidase S41A family
ASKIR_1821	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
ASKIR_1822	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
ASKIR_1823	COG0047	phosphoribosylformylglycinamidine synthase activity
ASKIR_1825	COG0204	Acyl-transferase
ASKIR_1826	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
ASKIR_1827	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ASKIR_1828	COG0018	arginyl-trna synthetase
ASKIR_1830	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
ASKIR_1831	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
ASKIR_1832	COG0126	phosphoglycerate kinase activity
ASKIR_1833	COG0149	triose-phosphate isomerase activity
ASKIR_1834	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
ASKIR_1835	COG0019	diaminopimelate decarboxylase activity
ASKIR_1836	COG0077	Prephenate dehydratase
ASKIR_1836	COG1605	Chorismate mutase
ASKIR_1837	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ASKIR_1838	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
ASKIR_1839	COG1858	cytochrome C peroxidase
ASKIR_1841	COG0424	maF-like protein
ASKIR_1847	COG0189	ligase activity
ASKIR_1850	COG2199	diguanylate cyclase activity
ASKIR_1850	COG2200	EAL domain
ASKIR_1850	COG3287	FIST C domain
ASKIR_1854	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
ASKIR_1855	COG0443	Heat shock 70 kDa protein
ASKIR_1856	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
ASKIR_1861	COG0310	cobalt ion transport
ASKIR_1864	COG0309	Hydrogenase expression formation protein (HypE)
ASKIR_1865	COG0409	Hydrogenase expression formation protein
ASKIR_1866	COG0298	carbon dioxide binding
ASKIR_1867	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
ASKIR_1869	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
ASKIR_1870	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
ASKIR_1871	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
ASKIR_1872	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
ASKIR_1873	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
ASKIR_1874	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
ASKIR_1878	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
ASKIR_1879	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
ASKIR_1880	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
ASKIR_1882	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
ASKIR_1883	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
ASKIR_1896	COG2226	methyltransferase
ASKIR_1900	COG1442	glycosyl transferase family 8
ASKIR_1900	COG1216	Glycosyl transferase, family 2
ASKIR_1904	COG1454	alcohol dehydrogenase
ASKIR_1908	COG0204	Acyl-transferase
ASKIR_1908	COG0318	PFAM AMP-dependent synthetase and ligase
ASKIR_1909	COG1028	Short-chain dehydrogenase reductase Sdr
ASKIR_1914	COG2089	acid synthase
ASKIR_1916	COG1083	cytidylyl-transferase
ASKIR_1917	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
ASKIR_1918	COG1086	Polysaccharide biosynthesis protein
ASKIR_1920	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
ASKIR_1921	COG0733	neurotransmitter:sodium symporter activity
ASKIR_1922	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
ASKIR_1923	COG0659	secondary active sulfate transmembrane transporter activity
ASKIR_1925	COG1222	aaa ATPase
ASKIR_1927	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
ASKIR_1928	COG0812	UDP-N-acetylmuramate dehydrogenase activity
ASKIR_1932	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
ASKIR_1933	COG0148	phosphopyruvate hydratase activity
ASKIR_1948	COG0464	growth
ASKIR_1954	COG0445	tRNA wobble uridine modification
ASKIR_1957	COG1077	Cell shape determining protein MreB Mrl
ASKIR_1958	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
ASKIR_1959	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ASKIR_1960	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
ASKIR_1961	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ASKIR_1962	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
ASKIR_1968	COG0670	Belongs to the BI1 family
ASKIR_1969	COG0352	thiamine-phosphate diphosphorylase activity
ASKIR_1971	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
ASKIR_1972	COG0233	cytoplasmic translational termination
ASKIR_1973	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
ASKIR_1977	COG3022	response to hydroperoxide
ASKIR_1981	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
ASKIR_1982	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
ASKIR_1983	COG1012	belongs to the aldehyde dehydrogenase family
ASKIR_1986	COG0783	Belongs to the Dps family
ASKIR_1987	COG2814	Major facilitator Superfamily
ASKIR_1988	COG4191	Histidine kinase
ASKIR_1988	COG0784	Response regulator, receiver
ASKIR_1991	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ASKIR_1992	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ASKIR_1995	COG0840	transmembrane signaling receptor activity
ASKIR_1996	COG2081	HI0933 family
ASKIR_1999	COG1959	2 iron, 2 sulfur cluster binding
ASKIR_2004	COG0175	sulfate reduction
ASKIR_2005	COG2895	sulfate adenylyltransferase (ATP) activity
ASKIR_2007	COG0133	tryptophan synthase activity
ASKIR_2011	COG1408	metallophosphoesterase
ASKIR_2012	COG1999	signal sequence binding
ASKIR_2015	COG2703	oxygen carrier activity
ASKIR_2016	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
ASKIR_2017	COG4208	sulfate ABC transporter
ASKIR_2018	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
ASKIR_2020	COG3287	FIST C domain
ASKIR_2020	COG2199	diguanylate cyclase activity
ASKIR_2020	COG2200	EAL domain
ASKIR_2023	COG0071	Belongs to the small heat shock protein (HSP20) family
ASKIR_2025	COG1217	gtp-binding protein TYPA
ASKIR_2026	COG2391	methyltransferase activity
ASKIR_2027	COG0425	Belongs to the sulfur carrier protein TusA family
ASKIR_2033	COG0745	RESPONSE REGULATOR receiver
ASKIR_2034	COG0642	Histidine kinase
ASKIR_2035	COG1368	sulfuric ester hydrolase activity
ASKIR_2036	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
ASKIR_2037	COG2860	membrane
ASKIR_2040	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group