locus-tag class description Alide2_0001 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) Alide2_0002 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) Alide2_0003 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) Alide2_0007 ENOG4105J1P transposase, IS3 IS911 family protein Alide2_0010 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F Alide2_0012 ENOG4107NQ8 LysR family Transcriptional regulator Alide2_0015 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase Alide2_0016 ENOG4105C1G acyl-Coa dehydrogenase Alide2_0017 ENOG4107QX3 carboxylase Alide2_0018 ENOG4105VSY K01512 acylphosphatase EC 3.6.1.7 Alide2_0020 ENOG4105D6E homoserine dehydrogenase Alide2_0021 ENOG4105DVT helicase Alide2_0023 ENOG4105K4H Nlp p60 protein Alide2_0024 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) Alide2_0025 ENOG4105BZU Histidine kinase Alide2_0027 ENOG4105JN3 extra-cytoplasmic solute receptor family protein Alide2_0028 ENOG4105D2B acyl-CoA dehydrogenase Alide2_0029 ENOG4105CC9 acyl-Coa dehydrogenase Alide2_0031 ENOG4105CD5 CoA-binding domain protein Alide2_0036 ENOG4105DH7 May be involved in recombination (By similarity) Alide2_0043 ENOG4105C8Q Methyl-accepting chemotaxis Alide2_0047 ENOG4105XJC Two component transcriptional regulator (Winged helix family Alide2_0048 ENOG4105ECM Sensor protein basS pmrB Alide2_0049 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase Alide2_0050 ENOG4108K3A Glutathione S-transferase Alide2_0051 ENOG4105KRS Proteinase inhibitor Alide2_0053 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) Alide2_0055 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) Alide2_0056 ENOG4108NIW Leucine export protein LeuE Alide2_0057 ENOG4107QJE Chromosome Partitioning Protein Alide2_0059 ENOG4105FA0 parb-like partition protein Alide2_0064 ENOG4105D64 Mechanosensitive ion channel Alide2_0066 ENOG4105CQB FAD linked oxidase domain protein Alide2_0068 ENOG4108WBT adenosyltransferase Alide2_0069 ENOG4105KA0 thioesterase Superfamily protein Alide2_0074 ENOG41061TZ Short-chain dehydrogenase reductase Sdr Alide2_0077 ENOG4105C2W permease Alide2_0080 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) Alide2_0081 ENOG4105CN8 Transcriptional regulator Alide2_0083 ENOG4105X7H acyl-CoA dehydrogenase Alide2_0084 ENOG4105D2B acyl-CoA dehydrogenase Alide2_0086 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase Alide2_0090 ENOG4105K7U Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) Alide2_0091 ENOG4107QMS site-determining protein Alide2_0092 ENOG4105VJP Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity) Alide2_0093 ENOG4105EJC lysr family transcriptional regulator Alide2_0095 ENOG4105CXK mandelate racemase muconate lactonizing Alide2_0097 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) Alide2_0103 ENOG4105C0M Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle (By similarity) Alide2_0105 ENOG4105C7B Threonine dehydratase Alide2_0106 ENOG4105CSU acyl-Coa dehydrogenase Alide2_0108 ENOG4105C3R Methionine synthase Alide2_0109 ENOG4107RSM transcriptional regulator Alide2_0113 ENOG4105C9U ATP-dependent DNA helicase RecQ Alide2_0117 ENOG4105BZU Histidine kinase Alide2_0120 ENOG4108JUA Transcriptional regulator Alide2_0122 ENOG4105EJQ L-serine dehydratase Alide2_0124 ENOG4105CEY Amp-dependent synthetase and ligase Alide2_0130 ENOG4105CEY Amp-dependent synthetase and ligase Alide2_0131 ENOG4105CHU acetyl-coa acetyltransferase Alide2_0134 ENOG4105K6S Short-chain dehydrogenase reductase Sdr Alide2_0139 ENOG4105CHU acetyl-coa acetyltransferase Alide2_0140 ENOG4105C1G acyl-Coa dehydrogenase Alide2_0143 ENOG4105KF3 Short-chain dehydrogenase reductase Sdr Alide2_0151 ENOG4105C1G acyl-Coa dehydrogenase Alide2_0152 ENOG4108M9J MaoC like domain protein Alide2_0153 ENOG4105KF3 Short-chain dehydrogenase reductase Sdr Alide2_0154 ENOG410900P UPF0336 protein Alide2_0155 ENOG4108UKI Enoyl-CoA hydratase Alide2_0156 ENOG4105CYC Transferase Alide2_0157 ENOG4105CHU acetyl-coa acetyltransferase Alide2_0162 ENOG4105ETT transcriptional Regulator, LysR family Alide2_0164 ENOG4105CH2 amidohydrolase Alide2_0166 ENOG4105CEY Amp-dependent synthetase and ligase Alide2_0169 ENOG4105CH2 amidohydrolase Alide2_0172 ENOG4105C1G acyl-Coa dehydrogenase Alide2_0175 ENOG4105JN3 extra-cytoplasmic solute receptor family protein Alide2_0177 ENOG4105C1G acyl-Coa dehydrogenase Alide2_0178 ENOG4107QX3 carboxylase Alide2_0179 ENOG4105C1G acyl-Coa dehydrogenase Alide2_0180 ENOG4105E39 Enoyl-CoA hydratase Alide2_0185 ENOG4105DUM transcriptional regulator, lysR family Alide2_0186 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F Alide2_0187 ENOG4108M0I Transcriptional regulator Alide2_0190 ENOG4105D82 Glutamate dehydrogenase Alide2_0192 ENOG4108ZK4 sdia-regulated domain-containing protein Alide2_0193 ENOG4105C3R Methionine synthase Alide2_0194 ENOG4105E9M CRISPR-associated protein, Csn1 family Alide2_0198 ENOG4105E5H Transposase Alide2_0204 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) Alide2_0207 ENOG4105DP0 ferredoxin-NADP reductase Alide2_0208 ENOG41083Z3 extracellular ligand-binding receptor Alide2_0209 ENOG4105C32 Amino acid ABC transporter (Permease) Alide2_0210 ENOG4108IV0 ABC, transporter Alide2_0214 ENOG4105C0P Mg chelatase subunit ChlI Alide2_0217 ENOG4105BZU Histidine kinase Alide2_0218 ENOG4105J1P transposase, IS3 IS911 family protein Alide2_0224 ENOG4107YUH hydrolase Alide2_0226 ENOG4108KK1 membrane protein AbrB duplication Alide2_0230 ENOG4105CD5 CoA-binding domain protein Alide2_0231 ENOG4105EU8 FAD linked oxidase domain protein Alide2_0233 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) Alide2_0236 ENOG4108J8Q Catalyzes the facilitated diffusion of 2-acyl-glycero-3- phosphoethanolamine (2-acyl-GPE) into the cell (By similarity) Alide2_0237 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) Alide2_0238 ENOG4105CA0 peroxidase Alide2_0239 ENOG4108RXX maleylacetoacetate isomerase Alide2_0240 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) Alide2_0242 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) Alide2_0244 ENOG4105CM2 brancheD-chain amino acid aminotransferase Alide2_0248 ENOG4105K64 Glycosyl transferase, family 2 Alide2_0251 ENOG4105EGI Transcriptional regulator Alide2_0252 ENOG4105CBP Major Facilitator Alide2_0253 ENOG4108RPX mosc domain containing protein Alide2_0259 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F Alide2_0260 ENOG4105JJR Histidine kinase Alide2_0261 ENOG4105CK6 Two component transcriptional regulator (Winged helix family Alide2_0265 ENOG4105D0M Protease HtpX homolog Alide2_0271 ENOG4105EUV Phenol 2-monooxygenase Alide2_0283 ENOG4105DIV Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD( ) and coenzyme A. Is the final enzyme in the meta- cleavage pathway for the degradation of aromatic compounds (By similarity) Alide2_0284 ENOG4105DF3 Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta-cleavage pathway for the degradation of aromatic compounds (By similarity) Alide2_0288 ENOG4105C5X domain protein Alide2_0289 ENOG41069M3 Transcriptional regulator Alide2_0291 ENOG4105GAK amidohydrolase 2 Alide2_0293 ENOG4105JSC dimethylmenaquinone methyltransferase Alide2_0294 ENOG4108JQ1 Dehydrogenase Alide2_0297 ENOG4105GAK amidohydrolase 2 Alide2_0298 ENOG4108TY5 Exhibits lactonase activity. Acts in cells with perturbed membrane integrity and is possibly related to the membrane homeostasis Alide2_0300 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase Alide2_0301 ENOG4105C26 Dehydrogenase Alide2_0302 ENOG4107258 Transcriptional regulator Alide2_0306 ENOG4105C32 Amino acid ABC transporter (Permease) Alide2_0308 ENOG4105C0Z ABC transporter Alide2_0309 ENOG4108IV0 ABC, transporter Alide2_0312 ENOG4105C1G acyl-Coa dehydrogenase Alide2_0313 ENOG4108R85 Short chain dehydrogenase Alide2_0315 ENOG4105CGK Exodeoxyribonuclease III Alide2_0316 ENOG4107QP2 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) Alide2_0318 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) Alide2_0319 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) Alide2_0320 ENOG41080G2 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) Alide2_0321 ENOG4105DFF Rod shape-determining protein mreb Alide2_0323 ENOG4105VQ7 Rod shape-determining protein MreD Alide2_0324 ENOG4105CJN penicillin-binding protein Alide2_0326 ENOG4105EJ9 Membrane Alide2_0329 ENOG4105DHJ ABC, transporter Alide2_0330 ENOG4105DY2 Paraquat-inducible protein b Alide2_0333 ENOG4105SKE transcriptional Regulator LysR family Alide2_0334 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) Alide2_0336 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) Alide2_0337 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein Alide2_0339 ENOG4105C0R drug resistance transporter emrb qaca subfamily Alide2_0340 ENOG4105CW7 secretion protein, HlyD family Alide2_0343 ENOG4105D7N magnesium and cobalt transport protein CorA Alide2_0344 ENOG4105D52 delta-aminolevulinic acid dehydratase Alide2_0346 ENOG4108YXA Membrane Alide2_0349 ENOG4105DHZ alpha beta Alide2_0350 ENOG4105DZ1 carboxypeptidase Alide2_0351 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) Alide2_0352 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) Alide2_0353 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) Alide2_0354 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) Alide2_0355 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) Alide2_0356 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) Alide2_0357 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) Alide2_0358 ENOG41080KG One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) Alide2_0359 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity Alide2_0360 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) Alide2_0361 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) Alide2_0362 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) Alide2_0363 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) Alide2_0364 ENOG41084PQ 50s ribosomal protein l29 Alide2_0365 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal Alide2_0366 ENOG4105EHV domain protein Alide2_0367 ENOG4105KY5 gCN5-related N-acetyltransferase Alide2_0369 ENOG4105KJP alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen Alide2_0372 ENOG41080Z8 PHOSPHOCARRIER protein Alide2_0373 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) Alide2_0374 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) Alide2_0375 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) Alide2_0376 ENOG4108Z43 UPF0250 protein Alide2_0378 ENOG4107RAZ it plays a direct role in the translocation of protons across the membrane (By similarity) Alide2_0379 ENOG4105KY6 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) Alide2_0381 ENOG4107S15 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) Alide2_0382 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) Alide2_0383 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) Alide2_0384 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) Alide2_0385 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) Alide2_0388 ENOG4105E5H Transposase Alide2_0397 ENOG4105MPD Cytochrome Alide2_0398 ENOG4105ENJ RND efflux system, outer membrane lipoprotein Alide2_0399 ENOG4105BZS acriflavin resistance protein Alide2_0400 ENOG4105C1P efflux transporter, rnd family, mfp subunit Alide2_0402 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) Alide2_0403 ENOG4105PM1 preprotein translocase subunit SecE Alide2_0405 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) Alide2_0406 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) Alide2_0407 ENOG4108VZM 50s ribosomal protein L10 Alide2_0408 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) Alide2_0409 ENOG4107QIH DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) Alide2_0410 ENOG4107QR0 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) Alide2_0412 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B Alide2_0414 ENOG4105ES5 Histidine kinase Alide2_0417 ENOG4105CMM transposase Alide2_0440 ENOG4108VDT Glycosyl transferase family protein Alide2_0441 ENOG4105CKK Glycosyl transferase, family 2 Alide2_0443 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) Alide2_0444 ENOG41082RQ UPF0102 protein Alide2_0445 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) Alide2_0447 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase Alide2_0448 ENOG4105CZX twitching motility protein Alide2_0449 ENOG4105IJJ transcriptional regulator, crp fnr family Alide2_0450 ENOG4105CZX twitching motility protein Alide2_0451 ENOG4105DFA alanine racemase domain protein Alide2_0454 ENOG4106BRA Membrane Alide2_0455 ENOG4105CQB FAD linked oxidase domain protein Alide2_0460 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) Alide2_0461 ENOG4105BZU Histidine kinase Alide2_0462 ENOG4105WH1 Two component transcriptional regulator luxr family Alide2_0464 ENOG4105DQQ Major facilitator superfamily MFS_1 Alide2_0465 ENOG4105CRU nitrate reductase, alpha subunit Alide2_0466 ENOG4108IUE nitrate reductase beta subunit Alide2_0467 ENOG4105R3A Nitrate reductase Alide2_0468 ENOG4105D0D Nitrate reductase 2, gamma subunit Alide2_0473 ENOG4105NSG hemerythrin hhe cation binding domain protein Alide2_0478 ENOG4108J2R molybdopterin oxidoreductase Alide2_0480 ENOG4105CI0 Citrate lyase Alide2_0481 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F Alide2_0482 ENOG4105DJG MaoC domain protein dehydratase Alide2_0483 ENOG4105C1G acyl-Coa dehydrogenase Alide2_0484 ENOG4105DJG MaoC domain protein dehydratase Alide2_0488 ENOG4105CH2 amidohydrolase Alide2_0491 ENOG4108R3E Dna-3-methyladenine glycosylase i Alide2_0493 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase Alide2_0497 ENOG4105DZS Phenylacetate-CoA ligase Alide2_0498 ENOG4108IV0 ABC, transporter Alide2_0501 ENOG4105C32 Amino acid ABC transporter (Permease) Alide2_0502 ENOG4105C0Z ABC transporter Alide2_0503 ENOG4108IQE Amp-dependent synthetase and ligase Alide2_0506 ENOG4105IJJ transcriptional regulator, crp fnr family Alide2_0507 ENOG4105FE9 pseudouridine synthase Alide2_0508 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) Alide2_0511 ENOG4105E27 serine threonine protein kinase Alide2_0514 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F Alide2_0517 ENOG4105CNV Aldolase Alide2_0519 ENOG4105ERH Fumarylacetoacetate hydrolase Alide2_0521 ENOG4105KME endoribonuclease L-psp Alide2_0523 ENOG4107XC4 flavin reductase domain protein, FMN-binding Alide2_0525 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase Alide2_0530 ENOG4105CJ1 ABC, transporter Alide2_0532 ENOG4105FYV Amp nucleosidase Alide2_0533 ENOG4105BZU Histidine kinase Alide2_0535 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) Alide2_0536 ENOG4105EJ9 Membrane Alide2_0539 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F Alide2_0540 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family Alide2_0541 ENOG4105CEY Amp-dependent synthetase and ligase Alide2_0542 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) Alide2_0543 ENOG4105C9A Phoh family Alide2_0544 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) Alide2_0547 ENOG4105CFG Acts as a chaperone (By similarity) Alide2_0549 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) Alide2_0556 ENOG4105CB3 Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity) Alide2_0563 ENOG41061DF Catalyzes the phosphorylation of N-acetylmannosamine (ManNAc) to ManNAc-6-P (By similarity) Alide2_0565 ENOG4105BZP glycoside hydrolase 15-related Alide2_0566 ENOG4108K4C ec 3.1.3.12 Alide2_0568 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate Alide2_0569 ENOG4108JUA Transcriptional regulator Alide2_0575 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase Alide2_0576 ENOG4105E4C Lytic transglycosylase catalytic Alide2_0579 ENOG4107E2E PKHD-type hydroxylase Alide2_0581 ENOG4108ESX Receptor Alide2_0583 ENOG4105CEY Amp-dependent synthetase and ligase Alide2_0586 ENOG4108RKI Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length (By similarity) Alide2_0587 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) Alide2_0588 ENOG4108JU5 Magnesium and cobalt efflux protein Alide2_0590 ENOG4108YXU transcriptional regulator AsnC family Alide2_0592 ENOG4105MIR Phenylalanine 4-monooxygenase Alide2_0593 ENOG4107R0V Pyruvate dehydrogenase Alide2_0594 ENOG4105CPP Dehydrogenase, E1 component Alide2_0595 ENOG4107QSN dihydrolipoamide acetyltransferase Alide2_0596 ENOG4107QN2 dihydrolipoyl dehydrogenase Alide2_0597 ENOG4107QIB glycyl-tRNA synthetase, alpha subunit Alide2_0598 ENOG4105C38 Glycyl-tRNA synthetase beta subunit Alide2_0599 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase Alide2_0600 ENOG4107S7E 1-acyl-sn-glycerol-3-phosphate acyltransferase Alide2_0603 ENOG4109066 lysm domain bon superfamily protein Alide2_0604 ENOG4108194 Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) Alide2_0605 ENOG4108IG5 Transcriptional regulator Alide2_0608 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase Alide2_0609 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) Alide2_0610 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase Alide2_0612 ENOG4105H63 Glycosyl transferase, family 2 Alide2_0613 ENOG4107QHF type ii secretion system protein e Alide2_0614 ENOG4105D7Q type ii secretion system Alide2_0619 ENOG4105UV2 general secretion pathway protein K Alide2_0626 ENOG4105MFV ABC-2 type transporter Alide2_0627 ENOG4105EY8 ABC transporter Alide2_0629 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) Alide2_0630 ENOG4105E4C Lytic transglycosylase catalytic Alide2_0632 ENOG4105CAS nag kinase Alide2_0633 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) Alide2_0635 ENOG4105CSU acyl-Coa dehydrogenase Alide2_0638 ENOG4105CHU acetyl-coa acetyltransferase Alide2_0640 ENOG41060WC Enoyl-CoA hydratase Alide2_0642 ENOG4105NAU thioesterase Superfamily protein Alide2_0643 ENOG4108JJ7 ABC transporter Alide2_0645 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit Alide2_0646 ENOG4105CG6 trap dicarboxylate transporter dctm subunit Alide2_0647 ENOG4105XDZ Tripartite ATP-independent periplasmic transporter Alide2_0648 ENOG4107YNJ LysR family Transcriptional regulator Alide2_0649 ENOG4107RP9 extracellular solute-binding protein, family 3 Alide2_0650 ENOG4105EAD ABC transporter Alide2_0651 ENOG4105DRP amino acid AbC transporter Alide2_0652 ENOG4105CDA abc transporter atp-binding protein Alide2_0653 ENOG4107QWB Ornithine cyclodeaminase Alide2_0655 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) Alide2_0657 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) Alide2_0659 ENOG4105SYT Methylenetetrahydrofolate reductase Alide2_0661 ENOG4105D6S protein involved in catabolism of external DNA Alide2_0662 ENOG4106PBJ Serine threonine-protein kinase Pkn6 Alide2_0663 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) Alide2_0664 ENOG4108UJD 30S ribosomal protein S9 Alide2_0665 ENOG4108YX9 iron--sulfur cluster insertion protein erpA Alide2_0666 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) Alide2_0667 ENOG4105DR5 peptidase Alide2_0668 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) Alide2_0669 ENOG4105ETT transcriptional Regulator, LysR family Alide2_0670 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) Alide2_0671 ENOG4105C08 Histidine kinase Alide2_0674 ENOG4105F7P transcriptional regulator AsnC family Alide2_0675 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) Alide2_0682 ENOG4105EQW The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity) Alide2_0683 ENOG4108S1C Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein) Alide2_0684 ENOG4105CK6 Two component transcriptional regulator (Winged helix family Alide2_0685 ENOG4105BZU Histidine kinase Alide2_0691 ENOG4108QV3 biosynthesis protein Alide2_0698 ENOG4105CAQ asparagine synthetase Alide2_0699 ENOG4105CPK Glycosyl transferase (Group 1 Alide2_0701 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) Alide2_0708 ENOG4105K64 Glycosyl transferase, family 2 Alide2_0711 ENOG4107QQG Dehydrogenase Alide2_0718 ENOG4105CEY Amp-dependent synthetase and ligase Alide2_0720 ENOG41062D9 Histidine kinase Alide2_0721 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family Alide2_0724 ENOG41060GT Translocates 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane (By similarity) Alide2_0726 ENOG4105DUM transcriptional regulator, lysR family Alide2_0729 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) Alide2_0730 ENOG4105CF1 Alkylated DNA repair protein Alide2_0731 ENOG4105CEY Amp-dependent synthetase and ligase Alide2_0736 ENOG4108RH0 Crea protein Alide2_0737 ENOG4105D9M gamma-glutamylcysteine synthetase Alide2_0738 ENOG4105D9M gamma-glutamylcysteine synthetase Alide2_0739 ENOG4105BZ1 (ABC) transporter Alide2_0744 ENOG4105D7Q type ii secretion system Alide2_0745 ENOG4105DEN Luciferase family Alide2_0747 ENOG4107QHF type ii secretion system protein e Alide2_0748 ENOG4105GVR general secretion pathway protein D Alide2_0753 ENOG4108WWZ General secretion pathway protein J Alide2_0756 ENOG4108VAU general secretion pathway protein G Alide2_0759 ENOG4108UHF Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) Alide2_0760 ENOG4105C7B Threonine dehydratase Alide2_0761 ENOG4108UKZ OsmC family Alide2_0762 ENOG4108S0N Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol (By similarity) Alide2_0763 ENOG4108Z9W Outer membrane porin Alide2_0766 ENOG4105CH2 amidohydrolase Alide2_0767 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component Alide2_0768 ENOG4105C3U ABC transporter Alide2_0769 ENOG4108JQ7 (ABC) transporter Alide2_0770 ENOG4108V1U phospholipid-binding protein Alide2_0772 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) Alide2_0773 ENOG4107QP8 phosphohexose isomerase Alide2_0774 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) Alide2_0775 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) Alide2_0776 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) Alide2_0777 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP Alide2_0779 ENOG4105D1S lipid A biosynthesis Alide2_0780 ENOG4105F04 LysR family Transcriptional regulator Alide2_0783 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) Alide2_0785 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) Alide2_0788 ENOG4105CRE cytochrome C Alide2_0789 ENOG4105CCD The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity) Alide2_0790 ENOG4105DQ2 Is probably involved in the electron transfer between its heme and the molybdenum cofactor of the reductase catalytic subunit YedY (By similarity) Alide2_0792 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) Alide2_0794 ENOG4105XQ6 frataxin-like protein Alide2_0795 ENOG4108JQC penicillin-binding protein 1A Alide2_0800 ENOG4105E4G Type IV pilus Alide2_0803 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein Alide2_0806 ENOG4105C26 Dehydrogenase Alide2_0812 ENOG4105EAB amino acid AbC transporter Alide2_0813 ENOG4105E5Q amino acid AbC transporter Alide2_0814 ENOG4105CDA abc transporter atp-binding protein Alide2_0816 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) Alide2_0817 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) Alide2_0818 ENOG4105DHJ ABC, transporter Alide2_0819 ENOG4105CY3 ABC transporter, permease Alide2_0820 ENOG4107PE3 Mammalian cell entry related domain protein Alide2_0824 ENOG4105BZU Histidine kinase Alide2_0825 ENOG4105DA5 (ABC) transporter Alide2_0826 ENOG4105E3A (ABC) transporter Alide2_0827 ENOG4105VFK BolA family Alide2_0828 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) Alide2_0829 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) Alide2_0833 ENOG4105CIH Imidazole acetol-phosphate transaminase Alide2_0834 ENOG4105ECC imidazole-glycerol-phosphate dehydratase Alide2_0836 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase Alide2_0839 ENOG4108I69 Glycosyl transferases group 1 Alide2_0845 ENOG4105CMR udp-glucose 4-epimerase Alide2_0846 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) Alide2_0847 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase Alide2_0848 ENOG4105KPZ phosphoribosyl-atp pyrophosphatase Alide2_0851 ENOG4107YU2 histidine triad (hIT) protein Alide2_0852 ENOG4105WKS Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) Alide2_0853 ENOG4107Z6S Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) Alide2_0854 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) Alide2_0855 ENOG4105C0H protease Alide2_0856 ENOG4107QNR UPF0135 protein Alide2_0857 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) Alide2_0858 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) Alide2_0859 ENOG4108R5F Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) Alide2_0860 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) Alide2_0861 ENOG4105EIX cytochrome c1 Alide2_0862 ENOG4107MKT Stringent starvation protein a Alide2_0863 ENOG4105KB2 stringent starvation protein b Alide2_0865 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving Alide2_0866 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) Alide2_0868 ENOG4105M6F mutator MutT protein Alide2_0869 ENOG41067SF Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase (By similarity) Alide2_0870 ENOG4105DHA Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity (By similarity) Alide2_0871 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) Alide2_0874 ENOG4107QHF type ii secretion system protein e Alide2_0887 ENOG4105J1P transposase, IS3 IS911 family protein Alide2_0888 ENOG4105EAH synthase Alide2_0889 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) Alide2_0890 ENOG4105K46 50S ribosomal protein l27 Alide2_0891 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control Alide2_0892 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) Alide2_0893 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) Alide2_0894 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) Alide2_0895 ENOG4106S48 Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and or cell division Alide2_0896 ENOG4105C37 (CBS) domain Alide2_0897 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) Alide2_0899 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) Alide2_0900 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) Alide2_0901 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) Alide2_0903 ENOG4108MGI Transcriptional regulator Alide2_0904 ENOG4105JN3 extra-cytoplasmic solute receptor family protein Alide2_0906 ENOG4105EGS Mechanosensitive ion channel Alide2_0907 ENOG4107T6V glycerophosphoryl diester phosphodiesterase Alide2_0908 ENOG4108IJ9 (ABC) transporter Alide2_0910 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component Alide2_0912 ENOG4108JQ1 Dehydrogenase Alide2_0916 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) Alide2_0919 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) Alide2_0923 ENOG4105C9M aspartyl-trna synthetase Alide2_0926 ENOG4105DZQ phospholipase D Transphosphatidylase Alide2_0927 ENOG4105EUJ GTP cyclohydrolase i Alide2_0930 ENOG4105BZU Histidine kinase Alide2_0931 ENOG4108ZXC Two component transcriptional regulator, luxr family Alide2_0932 ENOG4105NQN cytochrome C Alide2_0935 ENOG410829K Lysine exporter protein (Lyse ygga) Alide2_0936 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) Alide2_0938 ENOG4108JQ7 (ABC) transporter Alide2_0939 ENOG4105C3U ABC transporter Alide2_0940 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component Alide2_0942 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding Alide2_0943 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) Alide2_0944 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) Alide2_0945 ENOG4105C5T Phosphoribosyl pyrophosphate synthase Alide2_0946 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) Alide2_0948 ENOG4105DJQ tetratricopeptide tpr_2 repeat protein Alide2_0949 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) Alide2_0951 ENOG4105CEN a g-specific adenine glycosylase Alide2_0952 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) Alide2_0953 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) Alide2_0954 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) Alide2_0955 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) Alide2_0959 ENOG4105J1P transposase, IS3 IS911 family protein Alide2_0963 ENOG4105VNT transposase (IS4 family) protein Alide2_0965 ENOG4105CPW cytochrome b561 Alide2_0967 ENOG4105DHQ Histidine kinase Alide2_0968 ENOG4105ETX regulatoR Alide2_0972 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) Alide2_0973 ENOG4105CHQ Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity) Alide2_0975 ENOG4107QM5 aconitate hydratase Alide2_0977 ENOG4105JN3 extra-cytoplasmic solute receptor family protein Alide2_0979 ENOG4105CMJ mandelate racemase muconate lactonizing Alide2_0980 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr Alide2_0982 ENOG4105UVJ 5-dehydro-4-deoxyglucarate dehydratase Alide2_0983 ENOG4107YNJ LysR family Transcriptional regulator Alide2_0987 ENOG4106H78 methyltransferase Alide2_0988 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) Alide2_0989 ENOG4105K3G Periplasmic Protein Alide2_0991 ENOG4106H29 UPF0391 membrane protein Alide2_0993 ENOG4105WH1 Two component transcriptional regulator luxr family Alide2_0995 ENOG4105D06 uba thif-type nad fad binding protein Alide2_0996 ENOG4105CN1 protease Alide2_0997 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) Alide2_0998 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) Alide2_1000 ENOG4105IX2 One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity) Alide2_1001 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase Alide2_1007 ENOG4105DUM transcriptional regulator, lysR family Alide2_1008 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) Alide2_1009 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) Alide2_1011 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase Alide2_1012 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) Alide2_1015 ENOG4108IYU L-aspartate oxidase Alide2_1022 ENOG4105DMF Dehydrogenase Alide2_1024 ENOG4108ZX5 transcriptional regulator Alide2_1025 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) Alide2_1026 ENOG4105DFA alanine racemase domain protein Alide2_1027 ENOG4105DKK Benzoate Alide2_1030 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) Alide2_1033 ENOG4105CR7 Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA (By similarity) Alide2_1040 ENOG4105C1G acyl-Coa dehydrogenase Alide2_1041 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F Alide2_1042 ENOG4107EJG GntR family transcriptional regulator Alide2_1046 ENOG4108IEG Formate dehydrogenase Alpha subunit Alide2_1052 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) Alide2_1053 ENOG4105QAX Iron-sulfur Alide2_1057 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) Alide2_1058 ENOG4105CV6 ABC transporter, permease Alide2_1063 ENOG4105CAR Terminase, large subunit Alide2_1065 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) Alide2_1066 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) Alide2_1068 ENOG4105C98 muts2 protein Alide2_1070 ENOG4105W5Q DNA repair protein (RadC Alide2_1071 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase Alide2_1072 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) Alide2_1075 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) Alide2_1076 ENOG4105FFC UPF0187 protein Alide2_1079 ENOG4105DFP Integrase Alide2_1083 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) Alide2_1088 ENOG4105FFC UPF0187 protein Alide2_1093 ENOG4105CK6 Two component transcriptional regulator (Winged helix family Alide2_1094 ENOG4105C31 Tryptophanyl-tRNA synthetase Alide2_1095 ENOG4108Z4T Peptidase M50 Alide2_1096 ENOG4105C8Q Methyl-accepting chemotaxis Alide2_1097 ENOG4107RTD sua5 ycio yrdc ywlc family protein Alide2_1098 ENOG4105DB7 PHP domain protein Alide2_1099 ENOG4105C8Q Methyl-accepting chemotaxis Alide2_1100 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) Alide2_1102 ENOG4105D60 lipoprotein releasing system transmembrane protein Alide2_1103 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) Alide2_1104 ENOG4105W2Z cytochrome C, class I Alide2_1106 ENOG4105C01 Dihydroxy-acid dehydratase Alide2_1107 ENOG4105C01 Dihydroxy-acid dehydratase Alide2_1109 ENOG4108UWD Iron-storage protein Alide2_1110 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) Alide2_1111 ENOG4105DRR Transcriptional regulator, GntR family Alide2_1115 ENOG4105CEY Amp-dependent synthetase and ligase Alide2_1119 ENOG4105EUH cytochrome C oxidase, cbb3-type, subunit i Alide2_1126 ENOG4105DS0 Transcriptional regulator, Crp Fnr family Alide2_1127 ENOG4105D4P Coproporphyrinogen iii oxidase Alide2_1129 ENOG4108ESY Metal dependent phosphohydrolase Alide2_1130 ENOG4105BZU Histidine kinase Alide2_1133 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) Alide2_1134 ENOG4105C0Y Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) Alide2_1135 ENOG4108YZT Adenosylcobinamide kinase Alide2_1137 ENOG4105EHG Permease protein Alide2_1138 ENOG4105E0A ABC, transporter Alide2_1139 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase Alide2_1140 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) Alide2_1142 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase Alide2_1145 ENOG4105CHR reductase Alide2_1146 ENOG4107EXU Short-chain dehydrogenase reductase Sdr Alide2_1147 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F Alide2_1151 ENOG4105E39 Enoyl-CoA hydratase Alide2_1152 ENOG4105CC9 acyl-Coa dehydrogenase Alide2_1153 ENOG4105D2B acyl-CoA dehydrogenase Alide2_1157 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase Alide2_1158 ENOG4105E39 Enoyl-CoA hydratase Alide2_1161 ENOG4105CD5 CoA-binding domain protein Alide2_1162 ENOG4105C1G acyl-Coa dehydrogenase Alide2_1163 ENOG4105E39 Enoyl-CoA hydratase Alide2_1164 ENOG4105CHU acetyl-coa acetyltransferase Alide2_1166 ENOG4105CHU acetyl-coa acetyltransferase Alide2_1168 ENOG4105BZJ Electron transfer flavoprotein Alide2_1169 ENOG4105C10 Electron transfer flavoprotein Alide2_1170 ENOG4105C1G acyl-Coa dehydrogenase Alide2_1171 ENOG4105CC9 acyl-Coa dehydrogenase Alide2_1174 ENOG4105CHM Aminotransferase Alide2_1175 ENOG4105D6E homoserine dehydrogenase Alide2_1177 ENOG4107PBH Toxic component of a toxin-antitoxin (TA) module. A Alide2_1178 ENOG4105D98 threonine synthase Alide2_1179 ENOG4105FNP Molybdopterin-guanine dinucleotide biosynthesis protein b Alide2_1180 ENOG4105CVM Molybdenum cofactor synthesis domain protein Alide2_1182 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) Alide2_1186 ENOG4108ZAF Molybdopterin Alide2_1187 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit Alide2_1189 ENOG4107RGH Aldehyde dehydrogenase Alide2_1191 ENOG4107S47 Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) (By similarity) Alide2_1192 ENOG4105FBT Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) Alide2_1193 ENOG4107RZC phospholipase d Alide2_1194 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) Alide2_1201 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) Alide2_1203 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) Alide2_1204 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) Alide2_1206 ENOG4105CSM endonuclease III Alide2_1208 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) Alide2_1211 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family Alide2_1212 ENOG41069P5 Protein slyX homolog Alide2_1213 ENOG4105CPC Aldo Keto reductase Alide2_1216 ENOG4105VIG Sec-independent protein translocase protein TatC Alide2_1217 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) Alide2_1219 ENOG4105CYN Serine protein kinase Alide2_1220 ENOG4106AKX UPF0229 protein Alide2_1221 ENOG4105ED1 spovr family Alide2_1222 ENOG4105D01 (LipO)protein Alide2_1223 ENOG4108HRK Histidine kinase Alide2_1224 ENOG4105CH7 arginosuccinase Alide2_1227 ENOG4107S1Q Phosphatase Alide2_1228 ENOG4105DUM transcriptional regulator, lysR family Alide2_1230 ENOG4105HDK L-asparaginase Alide2_1231 ENOG4105C1G acyl-Coa dehydrogenase Alide2_1233 ENOG4105C1G acyl-Coa dehydrogenase Alide2_1234 ENOG4105IYB L-carnitine dehydratase bile acid-inducible protein F Alide2_1236 ENOG4105BZ4 penicillin-binding protein Alide2_1237 ENOG4108WS1 Alide2_1238 ENOG4105BZU Histidine kinase Alide2_1239 ENOG41090EK ompa motb domain protein Alide2_1240 ENOG4105DMF Dehydrogenase Alide2_1242 ENOG4105C1G acyl-Coa dehydrogenase Alide2_1243 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F Alide2_1245 ENOG4107RSM transcriptional regulator Alide2_1246 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) Alide2_1247 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor Alide2_1248 ENOG4105CSD Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) Alide2_1250 ENOG4105D1Q UPF0246 protein Alide2_1251 ENOG4105C03 ribonuclease Alide2_1252 ENOG4105EI2 Pseudouridine synthase Alide2_1253 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) Alide2_1255 ENOG4108E8C ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) Alide2_1256 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) Alide2_1257 ENOG4108UHJ MAF-like protein Alide2_1258 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein Alide2_1259 ENOG4105VGS 50s ribosomal protein l32 Alide2_1260 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) Alide2_1261 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) Alide2_1262 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase Alide2_1263 ENOG4105CHR reductase Alide2_1264 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) Alide2_1265 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) Alide2_1267 ENOG4105EMN RNA polymerase sigma factor Alide2_1270 ENOG4105C0H protease Alide2_1271 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) Alide2_1272 ENOG4105C3F Signal peptidase i Alide2_1274 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) Alide2_1275 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) Alide2_1276 ENOG41071DT Involved in DNA repair and RecF pathway recombination (By similarity) Alide2_1277 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) Alide2_1278 ENOG4105KJV Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) Alide2_1279 ENOG4107QPA Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides (By similarity) Alide2_1281 ENOG4108IV0 ABC, transporter Alide2_1282 ENOG4105C0Z ABC transporter Alide2_1283 ENOG4105CF8 branched-chain amino acid ABC transporter, permease Alide2_1284 ENOG4105C32 Amino acid ABC transporter (Permease) Alide2_1285 ENOG4105CP9 extracellular ligand-binding receptor Alide2_1287 ENOG4105CRK lysyL-tRNA synthetase Alide2_1289 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase Alide2_1290 ENOG4105PFA Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity) Alide2_1292 ENOG4105E2K Glycosyl transferase (Group 1 Alide2_1293 ENOG4105EVB acetyltransferase Alide2_1297 ENOG4108VIA integral membrane protein Alide2_1298 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) Alide2_1299 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) Alide2_1300 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) Alide2_1301 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase Alide2_1302 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) Alide2_1304 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) Alide2_1305 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) Alide2_1306 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) Alide2_1307 ENOG4106BSU Entericidin B Alide2_1308 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) Alide2_1310 ENOG4105CY0 Metallo-Beta-Lactamase Alide2_1312 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) Alide2_1313 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase Alide2_1315 ENOG4105XPQ lipid carrier protein Alide2_1316 ENOG4106RZ4 Peptidase U32 Alide2_1317 ENOG4105CFP Peptidase U32 Alide2_1318 ENOG4105C0F tryptophanase EC 4.1.99.1 Alide2_1320 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) Alide2_1321 ENOG4105CFG Acts as a chaperone (By similarity) Alide2_1322 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ Alide2_1323 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) Alide2_1325 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) Alide2_1326 ENOG4105K9Q Binds to the 23S rRNA (By similarity) Alide2_1327 ENOG4105CDU Replicative dna helicase Alide2_1328 ENOG4105C26 Dehydrogenase Alide2_1329 ENOG4108IAB Phoh family Alide2_1330 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen Alide2_1335 ENOG4105C6K Malic enzyme Alide2_1336 ENOG4105C2W permease Alide2_1337 ENOG4105C8Q Methyl-accepting chemotaxis Alide2_1339 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) Alide2_1342 ENOG4107YCY Transcriptional regulator Alide2_1343 ENOG4105EJC lysr family transcriptional regulator Alide2_1349 ENOG4107RP9 extracellular solute-binding protein, family 3 Alide2_1350 ENOG4105CC0 LysR family Transcriptional regulator Alide2_1351 ENOG41060W2 glyoxylate carboligase Alide2_1352 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) Alide2_1353 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase Alide2_1356 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) Alide2_1357 ENOG4105VT2 5-hydroxyisourate hydrolase Alide2_1361 ENOG4105DHP deoxycytidine triphosphate deaminase Alide2_1362 ENOG4105CGZ zinc metallopeptidase Alide2_1363 ENOG4105C1J atp-dependent rna helicase Alide2_1366 ENOG4108T0W nitrous oxide maturation protein NosY Alide2_1367 ENOG4105CIG ABC transporter Alide2_1368 ENOG4105DH4 Periplasmic copper-binding protein Alide2_1369 ENOG4105HEE Binding Domain protein Alide2_1372 ENOG4105MPD Cytochrome Alide2_1374 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) Alide2_1375 ENOG4107M1U Histone family protein nucleoid-structuring protein H-NS Alide2_1376 ENOG4107QM5 aconitate hydratase Alide2_1377 ENOG4105MSY salicylate hydroxylase Alide2_1379 ENOG4105DXI Major Facilitator superfamily Alide2_1380 ENOG4108VAC response regulator Alide2_1381 ENOG4105C2F Histidine kinase Alide2_1384 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) Alide2_1387 ENOG4105BZS acriflavin resistance protein Alide2_1389 ENOG4105ENJ RND efflux system, outer membrane lipoprotein Alide2_1390 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) Alide2_1399 ENOG4105DGI Alkaline phosphatase Alide2_1400 ENOG4105BZU Histidine kinase Alide2_1401 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) Alide2_1402 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) Alide2_1403 ENOG4108K5P (LipO)protein Alide2_1404 ENOG4105C34 Pseudouridine synthase Alide2_1405 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) Alide2_1406 ENOG4105FE9 pseudouridine synthase Alide2_1407 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) Alide2_1408 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs Alide2_1411 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) Alide2_1412 ENOG4105CUT histidyl-tRNA synthetase Alide2_1414 ENOG4105CNE Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) Alide2_1415 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) Alide2_1416 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) Alide2_1417 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) Alide2_1418 ENOG4107QJR hflk protein Alide2_1419 ENOG4105EPW hflc protein Alide2_1421 ENOG4105C49 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity) Alide2_1422 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis Alide2_1424 ENOG4105I08 Pseudouridine synthase Alide2_1430 ENOG4105C5F glutamine synthetase Alide2_1432 ENOG4105CUX Signal transduction histidine kinase Alide2_1433 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family Alide2_1434 ENOG4105CGK Exodeoxyribonuclease III Alide2_1436 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) Alide2_1437 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) Alide2_1439 ENOG4105C08 Histidine kinase Alide2_1440 ENOG4105EEX Two component transcriptional regulator (Winged helix family Alide2_1444 ENOG4105ER2 Ompa motb domain protein Alide2_1447 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) Alide2_1448 ENOG4105CQB FAD linked oxidase domain protein Alide2_1450 ENOG4107S2Z UPF0761 membrane protein Alide2_1452 ENOG4107VFM Dehydrogenase Alide2_1453 ENOG4105C8Q Methyl-accepting chemotaxis Alide2_1454 ENOG4105FE1 phytoene synthase Alide2_1457 ENOG4105BZS acriflavin resistance protein Alide2_1458 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation Alide2_1459 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) Alide2_1460 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) Alide2_1461 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) Alide2_1462 ENOG4108RZE Tetr family transcriptional regulator Alide2_1464 ENOG4105DJG MaoC domain protein dehydratase Alide2_1466 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F Alide2_1467 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F Alide2_1470 ENOG4108TKH Nitroreductase Alide2_1473 ENOG4105C32 Amino acid ABC transporter (Permease) Alide2_1475 ENOG4105C0Z ABC transporter Alide2_1476 ENOG4108IV0 ABC, transporter Alide2_1477 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase Alide2_1478 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr Alide2_1483 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F Alide2_1486 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F Alide2_1489 ENOG4105CHU acetyl-coa acetyltransferase Alide2_1493 ENOG4105C1G acyl-Coa dehydrogenase Alide2_1495 ENOG4105DTD Dehydrogenase Alide2_1496 ENOG4105E39 Enoyl-CoA hydratase Alide2_1498 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F Alide2_1508 ENOG4105C1G acyl-Coa dehydrogenase Alide2_1510 ENOG4105CHR reductase Alide2_1511 ENOG4105CHU acetyl-coa acetyltransferase Alide2_1512 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) Alide2_1514 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F Alide2_1516 ENOG4105DND Transcriptional regulator Alide2_1517 ENOG4105C1G acyl-Coa dehydrogenase Alide2_1518 ENOG4105BZJ Electron transfer flavoprotein Alide2_1519 ENOG4105C10 Electron transfer flavoprotein Alide2_1520 ENOG4108M9J MaoC like domain protein Alide2_1522 ENOG4105CI0 Citrate lyase Alide2_1524 ENOG4108IV0 ABC, transporter Alide2_1525 ENOG4105C0Z ABC transporter Alide2_1526 ENOG4105CF8 branched-chain amino acid ABC transporter, permease Alide2_1527 ENOG4105C32 Amino acid ABC transporter (Permease) Alide2_1529 ENOG4105CPQ Dehydrogenase Alide2_1530 ENOG4105C26 Dehydrogenase Alide2_1534 ENOG4105C26 Dehydrogenase Alide2_1535 ENOG4105C26 Dehydrogenase Alide2_1536 ENOG4105E39 Enoyl-CoA hydratase Alide2_1538 ENOG4108Z9W Outer membrane porin Alide2_1540 ENOG4105C32 Amino acid ABC transporter (Permease) Alide2_1541 ENOG4105CF8 branched-chain amino acid ABC transporter, permease Alide2_1542 ENOG4105C0Z ABC transporter Alide2_1543 ENOG4108IV0 ABC, transporter Alide2_1545 ENOG4105CEY Amp-dependent synthetase and ligase Alide2_1546 ENOG4105C1G acyl-Coa dehydrogenase Alide2_1552 ENOG4105C4R Atp-dependent dna helicase Alide2_1554 ENOG4105J1P transposase, IS3 IS911 family protein Alide2_1556 ENOG4105F2I Transposase Alide2_1557 ENOG4105F2I Transposase Alide2_1576 ENOG4106NZI LysR family Transcriptional regulator Alide2_1578 ENOG4105ENJ RND efflux system, outer membrane lipoprotein Alide2_1579 ENOG4107QWP ABC-2 type transporter Alide2_1580 ENOG4107QWP ABC-2 type transporter Alide2_1581 ENOG4105CJ1 ABC, transporter Alide2_1583 ENOG4105XEA Tetr family transcriptional regulator Alide2_1590 ENOG4107QJE Chromosome Partitioning Protein Alide2_1597 ENOG41085FC arsR family transcriptional regulator Alide2_1600 ENOG4105D6J arsenicaL-resistance protein Alide2_1601 ENOG4105K89 arsenate reductase Alide2_1602 ENOG4105VUN Transcriptional regulator Alide2_1605 ENOG4105FA0 parb-like partition protein Alide2_1609 ENOG4108YGG dna repair protein Alide2_1621 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) Alide2_1624 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) Alide2_1626 ENOG4105E39 Enoyl-CoA hydratase Alide2_1627 ENOG4105DZS Phenylacetate-CoA ligase Alide2_1628 ENOG4107QX3 carboxylase Alide2_1630 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase Alide2_1633 ENOG4105E39 Enoyl-CoA hydratase Alide2_1635 ENOG4105C6T cysteine synthase Alide2_1636 ENOG4105E09 nadh pyrophosphatase Alide2_1637 ENOG41082K8 Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity) Alide2_1638 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase Alide2_1639 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) Alide2_1644 ENOG4105EUH cytochrome C oxidase, cbb3-type, subunit i Alide2_1648 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) Alide2_1649 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) Alide2_1650 ENOG4106CIA Functions in complex with FlhD as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region Alide2_1651 ENOG4105GEH Functions in complex with FlhC as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region. Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes. Also regulates genes whose products function in a variety of physiological pathways (By similarity) Alide2_1652 ENOG4108UQY Iron-storage protein Alide2_1654 ENOG4108JU3 Alkyl hydroperoxide reductase Alide2_1655 ENOG4105CH6 catalase Alide2_1661 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) Alide2_1664 ENOG4107QN1 sodium solute Alide2_1666 ENOG4105CSU acyl-Coa dehydrogenase Alide2_1669 ENOG4105C1G acyl-Coa dehydrogenase Alide2_1670 ENOG410846T CoA-transferase family III Alide2_1671 ENOG4105CEY Amp-dependent synthetase and ligase Alide2_1672 ENOG4105F2C Acetyl-CoA acetyltransferase Alide2_1673 ENOG4105E39 Enoyl-CoA hydratase Alide2_1676 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) Alide2_1678 ENOG4105SKE transcriptional Regulator LysR family Alide2_1679 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F Alide2_1680 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase Alide2_1683 ENOG4105C5Q Transcriptional regulator Alide2_1687 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component Alide2_1689 ENOG4105CZE histidine utilization repressor Alide2_1690 ENOG4105C84 Histidine ammonia-lyase Alide2_1691 ENOG4105CZE histidine utilization repressor Alide2_1692 ENOG4105ETS cytosine purines uracil thiamine allantoin Alide2_1693 ENOG4105CGP Urocanate hydratase Alide2_1695 ENOG4105EAB amino acid AbC transporter Alide2_1696 ENOG4105E5Q amino acid AbC transporter Alide2_1697 ENOG4105CDA abc transporter atp-binding protein Alide2_1698 ENOG41090B9 response to stress Alide2_1699 ENOG4105CI2 imidazolone-5-propionate hydrolase Alide2_1702 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) Alide2_1704 ENOG4105CNV Aldolase Alide2_1705 ENOG4105C26 Dehydrogenase Alide2_1706 ENOG4105CTX dehydratase Alide2_1709 ENOG4105D78 K07001 NTE family protein Alide2_1710 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) Alide2_1711 ENOG4105EJC lysr family transcriptional regulator Alide2_1717 ENOG4106NZI LysR family Transcriptional regulator Alide2_1719 ENOG4105CHR reductase Alide2_1721 ENOG4105D1N poly(r)-hydroxyalkanoic acid synthase, class Alide2_1722 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) Alide2_1724 ENOG4105D0S secretion protein (HlyD Alide2_1725 ENOG4105CJ1 ABC, transporter Alide2_1726 ENOG4107QWP ABC-2 type transporter Alide2_1727 ENOG4107QWP ABC-2 type transporter Alide2_1730 ENOG4105CY0 Metallo-Beta-Lactamase Alide2_1731 ENOG4105EWT decarboxylase family Alide2_1735 ENOG4106NZI LysR family Transcriptional regulator Alide2_1738 ENOG4107QJE Chromosome Partitioning Protein Alide2_1747 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) Alide2_1765 ENOG4105MP0 transposase Alide2_1770 ENOG4105GR3 Histidine kinase Alide2_1773 ENOG4105CJ1 ABC, transporter Alide2_1787 ENOG4107QMH DNA methylase Alide2_1791 ENOG4105C0D helicase Alide2_1803 ENOG4105W5Q DNA repair protein (RadC Alide2_1819 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) Alide2_1821 ENOG4105W1Y Transcriptional regulator Alide2_1822 ENOG4105DFP Integrase Alide2_1824 ENOG4105E7D Protein of unknown function (DUF3375) Alide2_1835 ENOG4105D2B acyl-CoA dehydrogenase Alide2_1836 ENOG4105CC9 acyl-Coa dehydrogenase Alide2_1839 ENOG4107258 Transcriptional regulator Alide2_1840 ENOG4105CHR reductase Alide2_1841 ENOG4105CD5 CoA-binding domain protein Alide2_1843 ENOG4105UPE Enoyl-CoA hydratase Alide2_1844 ENOG4105CC9 acyl-Coa dehydrogenase Alide2_1849 ENOG410900P UPF0336 protein Alide2_1853 ENOG4105BZJ Electron transfer flavoprotein Alide2_1854 ENOG4105C10 Electron transfer flavoprotein Alide2_1855 ENOG4105E39 Enoyl-CoA hydratase Alide2_1856 ENOG4105EA8 2-Nitropropane dioxygenase Alide2_1859 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F Alide2_1860 ENOG4105CYC Transferase Alide2_1863 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F Alide2_1864 ENOG4105C1G acyl-Coa dehydrogenase Alide2_1865 ENOG4108Z7G MaoC domain protein dehydratase Alide2_1869 ENOG4105E39 Enoyl-CoA hydratase Alide2_1871 ENOG4107HP6 Transcriptional regulator Alide2_1873 ENOG4107QX3 carboxylase Alide2_1884 ENOG4108IYH Dna topoisomerase Alide2_1886 ENOG4105D6J arsenicaL-resistance protein Alide2_1888 ENOG4108YZ3 Glyoxalase Bleomycin resistance protein (Dioxygenase Alide2_1889 ENOG41085FC arsR family transcriptional regulator Alide2_1924 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) Alide2_1927 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) Alide2_1936 ENOG4105BZ1 (ABC) transporter Alide2_1937 ENOG4105BZ1 (ABC) transporter Alide2_1962 ENOG4108R8Z these effects are overcome by concomitant expression of antitoxin SohA (PrlF). Massive overexpression is toxic. Unlike most other characterized TA systems degrades rRNA, and co-folding of the proteins is necessary in vitro for inhibition of the RNase activity. It is not known if it has any sequence-specificity. Acts as a transcription factor. The YhaV PrlF complex binds the prlF-yhaV operon, probably negatively regulating its expression Alide2_1967 ENOG4105DFP Integrase Alide2_1968 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family Alide2_1970 ENOG4105DJ4 phosphatidylserine decarboxylase Alide2_1971 ENOG4108IJ8 ABC transporter Alide2_1972 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) Alide2_1973 ENOG4105BZU Histidine kinase Alide2_1975 ENOG41080YA This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) Alide2_1976 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) Alide2_1977 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase Alide2_1980 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) Alide2_1981 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) Alide2_1982 ENOG4105UYK outer membrane protein a Alide2_1983 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) Alide2_1984 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) Alide2_1993 ENOG4108C33 Resolvase Alide2_2013 ENOG4108ES9 ParB domain protein nuclease Alide2_2023 ENOG4105D07 Signal peptide peptidase, SppA Alide2_2049 ENOG4105DZR Type I site-specific deoxyribonuclease Alide2_2055 ENOG4105C0H protease Alide2_2056 ENOG4105D0M Protease HtpX homolog Alide2_2059 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) Alide2_2061 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit Alide2_2062 ENOG4105VN1 Heat shock protein Alide2_2066 ENOG4105KT5 UmuD protein Alide2_2076 ENOG4105J1P transposase, IS3 IS911 family protein Alide2_2078 ENOG4105CSV Glutaminase Alide2_2079 ENOG4105CH2 amidohydrolase Alide2_2080 ENOG4105CSH Transporter Alide2_2086 ENOG4105CHR reductase Alide2_2088 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein Alide2_2091 ENOG4105C0R drug resistance transporter emrb qaca subfamily Alide2_2092 ENOG4105CVP deoxyribo-dipyrimidine photolyase Alide2_2094 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) Alide2_2095 ENOG4105DZ2 Transcriptional regulator Alide2_2101 ENOG4105C7F AcnD-accessory protein PrpF Alide2_2102 ENOG4108I0Z Aconitate hydratase Alide2_2103 ENOG4105BZN citrate synthase Alide2_2105 ENOG4105CFF transcriptional regulator Alide2_2107 ENOG4109025 Glyoxalase Bleomycin resistance protein (Dioxygenase Alide2_2109 ENOG4105VEJ Heat shock protein Alide2_2110 ENOG4105DHQ Histidine kinase Alide2_2115 ENOG4106BE1 Participates in the degradation of poly-3- hydroxybutyrate (PHB). It works downstream of poly(3- hydroxybutyrate) depolymerase, hydrolyzing D(-)-3-hydroxybutyrate oligomers of various length (3HB-oligomers) into 3HB-monomers (By similarity) Alide2_2120 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) Alide2_2121 ENOG4105DFC had-superfamily hydrolase, subfamily ia, variant Alide2_2126 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase Alide2_2127 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) Alide2_2128 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) Alide2_2129 ENOG4106S48 Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and or cell division Alide2_2132 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) Alide2_2133 ENOG41061TZ Short-chain dehydrogenase reductase Sdr Alide2_2135 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding Alide2_2136 ENOG4105K63 Thioredoxin Alide2_2137 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) Alide2_2138 ENOG4105CHV Transcription elongation factor NusA Alide2_2139 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) Alide2_2140 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) Alide2_2141 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) Alide2_2144 ENOG4105E39 Enoyl-CoA hydratase Alide2_2148 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) Alide2_2149 ENOG4108Z1B Cyclase dehydrase Alide2_2152 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) Alide2_2153 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) Alide2_2161 ENOG4105FEQ ParB domain protein nuclease Alide2_2172 ENOG4105J1P transposase, IS3 IS911 family protein Alide2_2177 ENOG4107QJE Chromosome Partitioning Protein Alide2_2182 ENOG4107STQ Multicopper oxidase Alide2_2185 ENOG4105GR3 Histidine kinase Alide2_2187 ENOG4105E3B Multicopper oxidase Alide2_2197 ENOG4105D6P C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex (By similarity) Alide2_2198 ENOG4105C59 p-type ATPase Alide2_2203 ENOG4108IJF Heavy metal efflux pump, CzcA Alide2_2208 ENOG4105DFP Integrase Alide2_2209 ENOG4105BZN citrate synthase Alide2_2210 ENOG41060IS Flavinator of succinate dehydrogenase Alide2_2211 ENOG4105E33 succinate dehydrogenase Alide2_2213 ENOG4105N1I succinate dehydrogenase, hydrophobic membrane anchor protein Alide2_2214 ENOG4108UTY succinate dehydrogenase, cytochrome b556 subunit Alide2_2215 ENOG4105FDP GntR family transcriptional regulator Alide2_2216 ENOG4105D9Z Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) Alide2_2217 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) Alide2_2219 ENOG4107QIJ Aconitate hydratase 2 Alide2_2220 ENOG4107RSM transcriptional regulator Alide2_2221 ENOG4105CSU acyl-Coa dehydrogenase Alide2_2223 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F Alide2_2224 ENOG4105DC8 reductase Alide2_2228 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) Alide2_2231 ENOG4107P0T Selenium-dependent molybdenum hydroxylase system protein, YqeB family Alide2_2232 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) Alide2_2237 ENOG4105CKK Glycosyl transferase, family 2 Alide2_2238 ENOG4105CFP Peptidase U32 Alide2_2243 ENOG4108UYB regulatoR Alide2_2244 ENOG4105TX3 Histidine kinase Alide2_2246 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) Alide2_2247 ENOG4105CCU oxidase (Subunit III) Alide2_2248 ENOG4105BZ9 Cytochrome C oxidase, subunit I Alide2_2249 ENOG4105E2S oxidase) subunit II Alide2_2250 ENOG4105CSH Transporter Alide2_2252 ENOG4105M8F Biopolymer transport protein exbD tolR Alide2_2253 ENOG4105E02 MotA TolQ exbB proton channel Alide2_2254 ENOG4107YD3 Thioesterase Alide2_2255 ENOG4105CHM Aminotransferase Alide2_2256 ENOG4107YIM Involved in the transcription termination process (By similarity) Alide2_2257 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) Alide2_2258 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) Alide2_2261 ENOG4105KF3 Short-chain dehydrogenase reductase Sdr Alide2_2262 ENOG4105D9M gamma-glutamylcysteine synthetase Alide2_2265 ENOG4105M4H endoribonuclease L-psp Alide2_2271 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) Alide2_2273 ENOG4105DR9 pseudouridine synthase Alide2_2278 ENOG4105DTR rard protein Alide2_2279 ENOG4108R99 pseudouridine synthase Alide2_2281 ENOG4108IJ0 Aspartate ammonia-lyase Alide2_2284 ENOG4105CX6 glutaminyL-tRNA synthetase Alide2_2286 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) Alide2_2288 ENOG4108YZN class I peptide chain release factor Alide2_2289 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b Alide2_2292 ENOG4108YXU transcriptional regulator AsnC family Alide2_2293 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) Alide2_2294 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) Alide2_2296 ENOG4107RSM transcriptional regulator Alide2_2297 ENOG4105JXH GntR family transcriptional regulator Alide2_2298 ENOG4105CSP Major Facilitator Superfamily Alide2_2299 ENOG4105ZXK Dehydrogenase Alide2_2300 ENOG4105EXW epimerase dehydratase Alide2_2301 ENOG4105G63 Type III effector Hrp-dependent Alide2_2302 ENOG4105FB2 class II Aldolase Alide2_2303 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) Alide2_2304 ENOG4105EXZ Involved in the regulation of ptsG expression by binding and inactivating Mlc (By similarity) Alide2_2305 ENOG4105F10 Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity) Alide2_2310 ENOG4105C8N cysteinyl-tRNA synthetase Alide2_2313 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) Alide2_2314 ENOG4105CFH Aspartokinase Alide2_2315 ENOG4105CMQ Chloride channel Alide2_2316 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) Alide2_2319 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) Alide2_2320 ENOG4105CVE Lytic murein transglycosylase Alide2_2321 ENOG4105CJB Exodeoxyribonuclease I Alide2_2322 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) Alide2_2323 ENOG4105DSF transport protein Alide2_2324 ENOG4108YYQ gCN5-related N-acetyltransferase Alide2_2325 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) Alide2_2327 ENOG4105CDY transcriptional regulatory protein Alide2_2330 ENOG4105C4M (Ubiquinol oxidase) subunit I Alide2_2331 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii Alide2_2333 ENOG41067MG lrgb family Alide2_2335 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family Alide2_2336 ENOG4105CYM Glutathione S-transferase Alide2_2337 ENOG4105D7A ATP-binding protein Alide2_2338 ENOG4105CDY transcriptional regulatory protein Alide2_2339 ENOG4105C12 Phosphoribosylglycinamide synthetase Alide2_2340 ENOG4105DBS Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity) Alide2_2341 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) Alide2_2342 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) Alide2_2343 ENOG4108Z03 MAF-like protein Alide2_2347 ENOG4108UMR transcriptional regulator AsnC family Alide2_2351 ENOG4105F64 nitrite reductase Alide2_2352 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) Alide2_2353 ENOG4105C03 ribonuclease Alide2_2354 ENOG4105BZU Histidine kinase Alide2_2356 ENOG4105CHM Aminotransferase Alide2_2357 ENOG4107R11 Transcriptional regulator Alide2_2361 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) Alide2_2365 ENOG4108JQ1 Dehydrogenase Alide2_2371 ENOG4107YZX Universal stress protein Alide2_2374 ENOG4105CHU acetyl-coa acetyltransferase Alide2_2375 ENOG410904N short-chain dehydrogenase reductase Alide2_2376 ENOG4105D3G Pseudouridine synthase Alide2_2378 ENOG4108V1T peptidylprolyl cis-trans isomerase Alide2_2379 ENOG4105WH1 Two component transcriptional regulator luxr family Alide2_2382 ENOG4107QX9 Thiol disulfide interChange protein Alide2_2387 ENOG4105EMN RNA polymerase sigma factor Alide2_2389 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) Alide2_2390 ENOG4105BZC d-serine deaminase Alide2_2391 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein Alide2_2393 ENOG4105CCT upf0313 protein Alide2_2394 ENOG4105CGF Aromatic amino acid aminotransferase Alide2_2395 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) Alide2_2396 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family Alide2_2397 ENOG4105C3J Cysteine desulfurase Alide2_2398 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins Alide2_2401 ENOG4105C9I Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB Alide2_2402 ENOG4108ZIT Ferredoxin, 2FE-2S Alide2_2403 ENOG4108JDX DNA polymerase iii, epsilon subunit Alide2_2404 ENOG4105D5U fad dependent oxidoreductase Alide2_2408 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) Alide2_2409 ENOG4105E66 phosphoriboisomerase A Alide2_2411 ENOG4105DGW oligopeptidase A Alide2_2412 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) Alide2_2413 ENOG4108ZXC Two component transcriptional regulator, luxr family Alide2_2414 ENOG4105BZU Histidine kinase Alide2_2415 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) Alide2_2416 ENOG4107QSN dihydrolipoamide acetyltransferase Alide2_2417 ENOG4107QN2 dihydrolipoyl dehydrogenase Alide2_2422 ENOG4105ETT transcriptional Regulator, LysR family Alide2_2427 ENOG4105E5H Transposase Alide2_2434 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase Alide2_2438 ENOG4105K4H Nlp p60 protein Alide2_2440 ENOG4105C0R drug resistance transporter emrb qaca subfamily Alide2_2441 ENOG4105BZU Histidine kinase Alide2_2442 ENOG4105KK4 UPF0060 membrane protein Alide2_2444 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) Alide2_2446 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) Alide2_2447 ENOG4105D78 K07001 NTE family protein Alide2_2448 ENOG4108JQC penicillin-binding protein 1A Alide2_2453 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase Alide2_2455 ENOG4105D1N poly(r)-hydroxyalkanoic acid synthase, class Alide2_2456 ENOG4105CHU acetyl-coa acetyltransferase Alide2_2457 ENOG4105CHR reductase Alide2_2458 ENOG4105C5H ABC transporter Alide2_2460 ENOG4105C1G acyl-Coa dehydrogenase Alide2_2461 ENOG4105CEY Amp-dependent synthetase and ligase Alide2_2462 ENOG4106P55 Transcriptional regulator Alide2_2463 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) Alide2_2464 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) Alide2_2465 ENOG4105CZX twitching motility protein Alide2_2466 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) Alide2_2468 ENOG4108R3D Electron transport complex Alide2_2471 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) Alide2_2475 ENOG4108IQE Amp-dependent synthetase and ligase Alide2_2476 ENOG4105DRR Transcriptional regulator, GntR family Alide2_2477 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase Alide2_2479 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F Alide2_2482 ENOG4105DJT lAO AO transport system ATPase Alide2_2483 ENOG4107QX3 carboxylase Alide2_2484 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase Alide2_2486 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) Alide2_2489 ENOG4105DHQ Histidine kinase Alide2_2492 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) Alide2_2495 ENOG4107SA8 fad-dependent pyridine nucleotide-disulfide oxidoreductase Alide2_2496 ENOG4105DFG type I secretion outer membrane protein Alide2_2497 ENOG4105BZS acriflavin resistance protein Alide2_2499 ENOG4105KTU Transcriptional regulator, arsr family Alide2_2505 ENOG4105ETE Transcriptional regulator (LacI family Alide2_2506 ENOG4108R85 Short chain dehydrogenase Alide2_2507 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) Alide2_2511 ENOG4105DIJ Phosphoethanolamine transferase Alide2_2513 ENOG4105XJC Two component transcriptional regulator (Winged helix family Alide2_2514 ENOG4105DHQ Histidine kinase Alide2_2515 ENOG4105E39 Enoyl-CoA hydratase Alide2_2517 ENOG4105DQ4 alcohol dehydrogenase Alide2_2518 ENOG410846T CoA-transferase family III Alide2_2519 ENOG4105C1G acyl-Coa dehydrogenase Alide2_2521 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F Alide2_2523 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase Alide2_2525 ENOG4105C7J ABC transporter, permease Alide2_2527 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family Alide2_2528 ENOG4108EMS branched-chain alpha-keto acid dehydrogenase subunit E2 Alide2_2531 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) Alide2_2532 ENOG4107QKR Dehydrogenase Alide2_2534 ENOG4105CPP Dehydrogenase, E1 component Alide2_2535 ENOG4107RUY (E1 component), alpha subunit Alide2_2536 ENOG4105EW9 transcriptional regulator AsnC family Alide2_2537 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit Alide2_2539 ENOG4105CG6 trap dicarboxylate transporter dctm subunit Alide2_2540 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) Alide2_2541 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) Alide2_2542 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) Alide2_2543 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor Alide2_2546 ENOG4105C4W S-formylglutathione hydrolase Alide2_2550 ENOG4105NXH GreA GreB family elongation factor Alide2_2553 ENOG4105CSU acyl-Coa dehydrogenase Alide2_2554 ENOG4105C10 Electron transfer flavoprotein Alide2_2555 ENOG4105BZJ Electron transfer flavoprotein Alide2_2558 ENOG4105C7R Atpase associated with various cellular activities aaa_3 Alide2_2560 ENOG4105F8C transglutaminase domain-containing protein Alide2_2561 ENOG4105CVE Lytic murein transglycosylase Alide2_2568 ENOG4108PZW LysR family Transcriptional regulator Alide2_2569 ENOG4105CV1 Transketolase (EC 2.2.1.1) Alide2_2570 ENOG4105C5I Dehydrogenase Alide2_2571 ENOG4105DUM transcriptional regulator, lysR family Alide2_2572 ENOG4105HMI Membrane Alide2_2573 ENOG4105ES9 amino acid Alide2_2575 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) Alide2_2576 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) Alide2_2577 ENOG410624X efflux transporter, rnd family, mfp subunit Alide2_2579 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) Alide2_2580 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) Alide2_2582 ENOG4105C1P efflux transporter, rnd family, mfp subunit Alide2_2583 ENOG4105BZS acriflavin resistance protein Alide2_2584 ENOG4105ENJ RND efflux system, outer membrane lipoprotein Alide2_2585 ENOG4108IFG nitrite reductase, (NAD(P)H) Alide2_2590 ENOG4107S1N anthranilate phosphoribosyltransferase Alide2_2591 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) Alide2_2593 ENOG4105CBX hi0933 family Alide2_2597 ENOG4108UNV SUF system FeS assembly protein, NifU family Alide2_2598 ENOG4105C9B Cysteine desulfurase Alide2_2600 ENOG4105C3K feS assembly ATPase SufC Alide2_2602 ENOG4105VCC 30S ribosomal protein S21 Alide2_2604 ENOG4108ESY Metal dependent phosphohydrolase Alide2_2608 ENOG4105EXC Acyl-transferase Alide2_2609 ENOG4108EKC n-acetylglutamate synthase Alide2_2611 ENOG4105MWK D-amino acid dehydrogenase, small subunit Alide2_2614 ENOG4105C32 Amino acid ABC transporter (Permease) Alide2_2616 ENOG4105C0Z ABC transporter Alide2_2617 ENOG4108IV0 ABC, transporter Alide2_2618 ENOG41083Z3 extracellular ligand-binding receptor Alide2_2619 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) Alide2_2621 ENOG41073TP transcriptional regulator Alide2_2622 ENOG4105DHT Metal Dependent Phosphohydrolase Alide2_2623 ENOG41080I0 Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity) Alide2_2624 ENOG4108IJ6 ABC transporter Alide2_2626 ENOG4108I5D sulfate abc transporter Alide2_2627 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein Alide2_2630 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) Alide2_2632 ENOG4105D01 (LipO)protein Alide2_2633 ENOG4108UMI ABC transporter, permease Alide2_2634 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) Alide2_2636 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) Alide2_2637 ENOG4105KDX Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) Alide2_2638 ENOG4107QMP dna polymerase iii subunits gamma and tau Alide2_2639 ENOG4105F4R Transcriptional regulator mode Alide2_2640 ENOG4107XWS modD protein Alide2_2641 ENOG4105E0C molybdate abc transporter Alide2_2642 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein Alide2_2645 ENOG4105E0A ABC, transporter Alide2_2646 ENOG4108I9K permease protein Alide2_2647 ENOG4105S10 periplasmic binding protein Alide2_2649 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) Alide2_2652 ENOG4105EUB pirin domain protein Alide2_2653 ENOG4105EUB pirin domain protein Alide2_2655 ENOG4105C5N The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination Alide2_2656 ENOG4105K63 Thioredoxin Alide2_2657 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) Alide2_2658 ENOG4105NRA 50s ribosomal protein l31 type b Alide2_2660 ENOG4107QI1 Mate efflux family protein Alide2_2661 ENOG4105BZU Histidine kinase Alide2_2662 ENOG4105CK6 Two component transcriptional regulator (Winged helix family Alide2_2663 ENOG4108UTW Plays a role in the regulation of phosphate uptake Alide2_2664 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) Alide2_2665 ENOG4105E2Z phosphate ABC transporter (Permease Alide2_2666 ENOG4105C8U phosphate abc transporter Alide2_2667 ENOG4107QMV Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) Alide2_2668 ENOG4105C9X ppx gppa phosphatase Alide2_2672 ENOG4105BZU Histidine kinase Alide2_2673 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) Alide2_2675 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) Alide2_2676 ENOG4105F7M Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity) Alide2_2677 ENOG4105HBR Rna-binding protein Alide2_2680 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) Alide2_2681 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain Alide2_2685 ENOG4105J1P transposase, IS3 IS911 family protein Alide2_2698 ENOG4105K70 DNA-binding protein Alide2_2701 ENOG4105CMM transposase Alide2_2711 ENOG4105VQ0 flagellar hook-basal body complex protein fliE Alide2_2712 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) Alide2_2713 ENOG4105W1Y Transcriptional regulator Alide2_2714 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase Alide2_2716 ENOG4107QRI Phosphoketolase Alide2_2720 ENOG4105C5I Dehydrogenase Alide2_2724 ENOG4105C0H protease Alide2_2725 ENOG4105C5T Phosphoribosyl pyrophosphate synthase Alide2_2726 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) Alide2_2727 ENOG4105CY0 Metallo-Beta-Lactamase Alide2_2729 ENOG4105HA9 of methanol dehydrogenase type Alide2_2733 ENOG4105CSR polyphosphate kinase 2 Alide2_2739 ENOG4108IJF Heavy metal efflux pump, CzcA Alide2_2743 ENOG4107PU6 Membrane Alide2_2756 ENOG4105J1P transposase, IS3 IS911 family protein Alide2_2806 ENOG4105T95 Thiol disulfide interChange protein Alide2_2823 ENOG4108XDN Transcriptional regulator Alide2_2824 ENOG4108ZUF This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) Alide2_2825 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) Alide2_2826 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) Alide2_2827 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) Alide2_2828 ENOG4105VJV 50s ribosomal protein L35 Alide2_2829 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) Alide2_2830 ENOG4105C22 threonyL-tRNA synthetase Alide2_2832 ENOG4108I9X Isocitrate lyase Alide2_2838 ENOG4105SG9 biopolymer transport protein, ExbD Alide2_2840 ENOG4108ZJF Glcg protein Alide2_2841 ENOG4108MN8 Membrane Alide2_2845 ENOG410814C multidrug resistance protein Alide2_2848 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) Alide2_2850 ENOG4105KCV RNA signal recognition particle 4.5S RNA Alide2_2857 ENOG4105C2N RNA methyltransferase TrmH family group 3 Alide2_2858 ENOG4107QV7 Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) (By similarity) Alide2_2859 ENOG4108I0Y (ABC) transporter Alide2_2860 ENOG4108UJV acyl-CoA thioesterase i Alide2_2862 ENOG4105C28 cystathionine Alide2_2865 ENOG4105BZU Histidine kinase Alide2_2867 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) Alide2_2869 ENOG4105D8V Glucose sorbosone dehydrogenase Alide2_2870 ENOG4106NZI LysR family Transcriptional regulator Alide2_2871 ENOG4105C26 Dehydrogenase Alide2_2873 ENOG4105C1G acyl-Coa dehydrogenase Alide2_2875 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase Alide2_2879 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) Alide2_2880 ENOG41090ED Protein with unknown function (DUF469) Alide2_2881 ENOG4105CTX dehydratase Alide2_2883 ENOG4105EQX glucarate dehydratase Alide2_2886 ENOG4105UVJ 5-dehydro-4-deoxyglucarate dehydratase Alide2_2888 ENOG4105C5I Dehydrogenase Alide2_2889 ENOG4105EQX glucarate dehydratase Alide2_2891 ENOG4108R4Z Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity) Alide2_2892 ENOG4105DWA May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate Alide2_2894 ENOG4105EQ1 Transcriptional regulator Alide2_2895 ENOG4105CVN desaturase Alide2_2896 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) Alide2_2897 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) Alide2_2898 ENOG4106TD9 Diguanylate cyclase Alide2_2899 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) Alide2_2900 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) Alide2_2902 ENOG4105CG6 trap dicarboxylate transporter dctm subunit Alide2_2903 ENOG41062YB Trap dicarboxylate transporter, dctp subunit Alide2_2904 ENOG4105DG4 malate L-lactate dehydrogenase Alide2_2905 ENOG4108WYP Transcriptional regulator Alide2_2906 ENOG4105D3G Pseudouridine synthase Alide2_2907 ENOG4105CD5 CoA-binding domain protein Alide2_2908 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase Alide2_2909 ENOG4107QKV phosphomannomutase Alide2_2912 ENOG4105DH8 myo-inositol catabolism Alide2_2919 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A Alide2_2920 ENOG4108Z6B deaminase Alide2_2922 ENOG4105CFP Peptidase U32 Alide2_2925 ENOG41067HS methyltransferase Alide2_2927 ENOG4105CKW Inner membrane protein yedI Alide2_2928 ENOG4108ETH Formylglycinamide ribotide synthetase Alide2_2929 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) Alide2_2931 ENOG4105C2W permease Alide2_2932 ENOG4108RBJ Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) Alide2_2933 ENOG4105WD1 Membrane Alide2_2939 ENOG4105E9K Isocitrate dehydrogenase Alide2_2940 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) Alide2_2941 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) Alide2_2943 ENOG4105M8F Biopolymer transport protein exbD tolR Alide2_2944 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) Alide2_2945 ENOG4105W49 UPF0434 protein Alide2_2946 ENOG4105CET Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) Alide2_2947 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) Alide2_2948 ENOG4105HDK L-asparaginase Alide2_2949 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) Alide2_2951 ENOG4105CQ7 ATP-dependent helicase Alide2_2952 ENOG4105CHU acetyl-coa acetyltransferase Alide2_2953 ENOG4107F3J Amp-dependent synthetase and ligase Alide2_2954 ENOG4107ZYJ bioY protein Alide2_2956 ENOG4108JJB ABC transporter Alide2_2959 ENOG4108UYE Lactoylglutathione lyase Alide2_2971 ENOG4107QJE Chromosome Partitioning Protein Alide2_2976 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) Alide2_2978 ENOG4105EVH UPF0753 protein Alide2_2979 ENOG4108TWJ NADH dehydrogenase subunit 5 Alide2_2980 ENOG4105DND Transcriptional regulator Alide2_2981 ENOG4105DU1 integral membrane protein, terc Alide2_2984 ENOG41063Z6 transcriptional regulator, lysR family Alide2_2986 ENOG4105ECP epimerase Alide2_2988 ENOG4105EXX Deoxyribodipyrimidine photolyase-related protein Alide2_2990 ENOG4105CVP deoxyribo-dipyrimidine photolyase Alide2_2991 ENOG4105QNF Outer membrane lipoprotein Alide2_2995 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase Alide2_3002 ENOG4105CVP deoxyribo-dipyrimidine photolyase Alide2_3006 ENOG4105DFS Conserved Protein Alide2_3009 ENOG4108UHU Aldolase Alide2_3010 ENOG4105C01 Dihydroxy-acid dehydratase Alide2_3011 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit Alide2_3012 ENOG4105CG6 trap dicarboxylate transporter dctm subunit Alide2_3013 ENOG4105XDZ Tripartite ATP-independent periplasmic transporter Alide2_3014 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family Alide2_3015 ENOG4107P2S Transcriptional regulator Alide2_3016 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit Alide2_3017 ENOG4105KAE Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) Alide2_3018 ENOG4105C0B DNA polymerase III (alpha subunit) Alide2_3020 ENOG4105DVT helicase Alide2_3021 ENOG4108ZF3 Phosphatase Alide2_3023 ENOG4105D6Z AFG1 family ATPase Alide2_3024 ENOG4107QN2 dihydrolipoyl dehydrogenase Alide2_3025 ENOG4105C7S Dehydrogenase Alide2_3026 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 Alide2_3027 ENOG4105IPI Membrane Alide2_3031 ENOG4105DUM transcriptional regulator, lysR family Alide2_3033 ENOG4108JQ5 ABC transporter Alide2_3034 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component Alide2_3035 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component Alide2_3038 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH Alide2_3040 ENOG4105Z2P Protein of unknown function (DUF465) Alide2_3042 ENOG4108ZCF integral membrane protein Alide2_3043 ENOG4105CXN decarboxylase Alide2_3046 ENOG4105ETT transcriptional Regulator, LysR family Alide2_3047 ENOG4105C7K acetolactate synthase Alide2_3053 ENOG4105J1P transposase, IS3 IS911 family protein Alide2_3057 ENOG4105E5H Transposase Alide2_3062 ENOG4108NF7 phage-type endonuclease Alide2_3069 ENOG4105CQ2 DNA polymerase Alide2_3071 ENOG410679B prophage CP4-57 regulatory protein alpA Alide2_3074 ENOG4105CHQ Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity) Alide2_3079 ENOG4105CHR reductase Alide2_3080 ENOG4105J5T Amp-dependent synthetase and ligase Alide2_3082 ENOG4108IV0 ABC, transporter Alide2_3083 ENOG4105C0Z ABC transporter Alide2_3085 ENOG4105C32 Amino acid ABC transporter (Permease) Alide2_3087 ENOG4105CHR reductase Alide2_3088 ENOG4105CHU acetyl-coa acetyltransferase Alide2_3092 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein Alide2_3093 ENOG4105KMG Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes (By similarity) Alide2_3094 ENOG4105EN6 Membrane Alide2_3095 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) Alide2_3096 ENOG4107TSN permease Alide2_3100 ENOG4105C11 sulfate adenylyltransferase), subunit 2 Alide2_3102 ENOG4108Z4U Ferredoxin Alide2_3103 ENOG4105CAY ferredoxin--nadp reductase Alide2_3109 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) Alide2_3110 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) Alide2_3112 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase Alide2_3113 ENOG4108UKI Enoyl-CoA hydratase Alide2_3116 ENOG4105C1G acyl-Coa dehydrogenase Alide2_3117 ENOG4105C26 Dehydrogenase Alide2_3118 ENOG4105CK7 Sodium proline symporter Alide2_3119 ENOG41069M3 Transcriptional regulator Alide2_3120 ENOG41061WM D-Alanyl-D-Alanine Alide2_3121 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) Alide2_3122 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) Alide2_3123 ENOG4108M0I Transcriptional regulator Alide2_3125 ENOG4105D2S major facilitator superfamily Alide2_3127 ENOG4108RXX maleylacetoacetate isomerase Alide2_3128 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase Alide2_3129 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase Alide2_3130 ENOG4108ZP8 Acetolactate synthase small subunit Alide2_3131 ENOG4105C7K acetolactate synthase Alide2_3132 ENOG4105JVQ RNA Polymerase Alide2_3136 ENOG41080IJ Diacylglycerol kinase Alide2_3137 ENOG4108URH decarboxylase Alide2_3138 ENOG4108YZA Nitrogen regulatory protein pii Alide2_3139 ENOG4105C4K Nad synthetase Alide2_3142 ENOG4105C8Q Methyl-accepting chemotaxis Alide2_3143 ENOG4108V3W Chemotaxis protein, CheW Alide2_3144 ENOG4105F0N pyrophosphate phospho-hydrolase Alide2_3149 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) Alide2_3150 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) Alide2_3152 ENOG4105CVM Molybdenum cofactor synthesis domain protein Alide2_3157 ENOG4107RP9 extracellular solute-binding protein, family 3 Alide2_3158 ENOG4105CN8 Transcriptional regulator Alide2_3159 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) Alide2_3160 ENOG4105JSC dimethylmenaquinone methyltransferase Alide2_3161 ENOG4105CHM Aminotransferase Alide2_3162 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) Alide2_3163 ENOG4105D1A Methyltransferase Alide2_3164 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) Alide2_3165 ENOG4105E9H Lytic Murein transglycosylase Alide2_3168 ENOG41067CV Integrase Alide2_3179 ENOG4105CUZ uba thif-type nad fad binding protein Alide2_3180 ENOG4105UFD tol-pal system protein YbgF Alide2_3181 ENOG4105KCK Peptidoglycan-associated lipoprotein Alide2_3182 ENOG4107R6Y Involved in the TonB-independent uptake of proteins (By similarity) Alide2_3183 ENOG4105BZ1 (ABC) transporter Alide2_3184 ENOG4108JIK carboxylase Alide2_3185 ENOG4105P4J Allophanate hydrolase, subunit 1 Alide2_3186 ENOG4105CFM UPF0317 protein Alide2_3187 ENOG4105E7W lamb ycsf family protein Alide2_3188 ENOG4107RGD Major Facilitator superfamily Alide2_3189 ENOG4105DRR Transcriptional regulator, GntR family Alide2_3193 ENOG4105F8V Hydrolase, tatD family Alide2_3195 ENOG4107QRG dna polymerase iii Alide2_3196 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) Alide2_3197 ENOG4105HHA aminodeoxychorismate lyase Alide2_3198 ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) Alide2_3199 ENOG4107Y2X deaminase Alide2_3200 ENOG4105DJ2 Major Facilitator Superfamily Alide2_3202 ENOG4108ZXC Two component transcriptional regulator, luxr family Alide2_3206 ENOG4105IKQ hydratase Alide2_3211 ENOG4105JN3 extra-cytoplasmic solute receptor family protein Alide2_3214 ENOG4105ETE Transcriptional regulator (LacI family Alide2_3216 ENOG4105CEY Amp-dependent synthetase and ligase Alide2_3222 ENOG4105BZM domain protein Alide2_3227 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) Alide2_3231 ENOG4105UGU tonB-dependent Receptor Alide2_3232 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) Alide2_3233 ENOG4105YA8 Transcriptional regulator Alide2_3234 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) Alide2_3236 ENOG4105DFG type I secretion outer membrane protein Alide2_3237 ENOG4106PHI plasmid recombination enzyme Alide2_3241 ENOG4105CSU acyl-Coa dehydrogenase Alide2_3242 ENOG4105DRP amino acid AbC transporter Alide2_3243 ENOG4105DRP amino acid AbC transporter Alide2_3245 ENOG4105CHU acetyl-coa acetyltransferase Alide2_3246 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase Alide2_3247 ENOG4108IV0 ABC, transporter Alide2_3248 ENOG4105C0Z ABC transporter Alide2_3250 ENOG4105C32 Amino acid ABC transporter (Permease) Alide2_3252 ENOG4105CEY Amp-dependent synthetase and ligase Alide2_3253 ENOG4105CNG UPF0061 protein Alide2_3254 ENOG4105E0X reductase Alide2_3255 ENOG4107835 probably involved in intracellular septation (By similarity) Alide2_3257 ENOG4107TF3 peptidylprolyl cis-trans isomerase Alide2_3259 ENOG4105CFV Tetratricopeptide repeat protein Alide2_3261 ENOG4105D65 subunit l Alide2_3262 ENOG4108ZE9 Monovalent cation H antiporter subunit C Alide2_3263 ENOG4107R4Z monovalent cation h antiporter subunit d Alide2_3265 ENOG4105W4C monovalent cation H antiporter subunit F Alide2_3268 ENOG4107Z6W Protein CrcB homolog Alide2_3271 ENOG4105CGY Dna recombination protein Alide2_3272 ENOG4105C5I Dehydrogenase Alide2_3274 ENOG4107RH7 Nicotinate phosphoribosyltransferase Alide2_3276 ENOG4108WFY phasin family Alide2_3277 ENOG4107QKW extracellular solute-binding protein family 1 Alide2_3294 ENOG4105FA0 parb-like partition protein Alide2_3345 ENOG4105T95 Thiol disulfide interChange protein Alide2_3365 ENOG4105CSR polyphosphate kinase 2 Alide2_3366 ENOG4105C59 p-type ATPase Alide2_3369 ENOG4105HA9 of methanol dehydrogenase type Alide2_3371 ENOG4105CY0 Metallo-Beta-Lactamase Alide2_3372 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) Alide2_3374 ENOG4105C0H protease Alide2_3375 ENOG4105C5B carbamate kinase Alide2_3381 ENOG4105W1Y Transcriptional regulator Alide2_3384 ENOG4105VQ0 flagellar hook-basal body complex protein fliE Alide2_3387 ENOG4108IJF Heavy metal efflux pump, CzcA Alide2_3394 ENOG41082YX Transcriptional regulator, arsr family Alide2_3395 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) Alide2_3411 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) Alide2_3412 ENOG4105C28 cystathionine Alide2_3413 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase Alide2_3414 ENOG4105E96 Colicin v production protein Alide2_3416 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase Alide2_3417 ENOG4105KUZ arsenate reductase Alide2_3419 ENOG4105NBK UPF0345 protein Alide2_3420 ENOG4105CDH Citrulline--aspartate ligase Alide2_3421 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family Alide2_3422 ENOG4105HKX acetone carboxylase, gamma subunit Alide2_3423 ENOG4107TYC hydantoinase B oxoprolinase Alide2_3424 ENOG4107RID 5-oxoprolinase (ATP-hydrolyzing) Alide2_3425 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) Alide2_3426 ENOG4105EX9 Membrane Alide2_3428 ENOG4105D4A Cell wall formation (By similarity) Alide2_3429 ENOG4108VPT UPF0234 protein Alide2_3430 ENOG4108WIW Aspartyl protease Alide2_3432 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) Alide2_3433 ENOG4108Z66 YbaK ebsC protein Alide2_3434 ENOG4105CPC Aldo Keto reductase Alide2_3435 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) Alide2_3437 ENOG4106JDA Phosphoglycerate transport regulatory protein PGTC Alide2_3441 ENOG4105CD8 aminopeptidase N Alide2_3442 ENOG4105CZI D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 Alide2_3454 ENOG4108IYT Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) Alide2_3456 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) Alide2_3457 ENOG4105D0V Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) Alide2_3458 ENOG4105DAF Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) Alide2_3459 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) Alide2_3460 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) Alide2_3462 ENOG4105E1Z Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane Alide2_3463 ENOG4105DZP Membrane-associated zinc metalloprotease Alide2_3464 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) Alide2_3465 ENOG4105KNE Phosphatidate cytidylyltransferase Alide2_3466 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) Alide2_3467 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) Alide2_3468 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) Alide2_3469 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) Alide2_3470 ENOG4105CE9 30S ribosomal protein S2 Alide2_3478 ENOG4105W1Y Transcriptional regulator Alide2_3484 ENOG4105KXX peptidase s58 dmpa Alide2_3486 ENOG4105C5H ABC transporter Alide2_3487 ENOG4105C1J atp-dependent rna helicase Alide2_3495 ENOG4105ETT transcriptional Regulator, LysR family Alide2_3496 ENOG4105C1G acyl-Coa dehydrogenase Alide2_3497 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F Alide2_3504 ENOG4105EGI Transcriptional regulator Alide2_3510 ENOG4105SA9 Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) Alide2_3513 ENOG4105DJ0 Poly(A) Polymerase Alide2_3515 ENOG4108KZ1 Mediates the interaction of DNA replication inititator protein DnaA with DNA polymerase subunit beta sliding clamp (dnaN). Stimulates hydrolysis of ATP-DnaA to ADP-DnaA, rendering DnaA inactive for reinititation, a process called regulatory inhibition of DnaA or RIDA (By similarity) Alide2_3516 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) Alide2_3517 ENOG4105CXB phosphoribosylaminoimidazole synthetase Alide2_3519 ENOG4105SHT UspA domain-containing protein Alide2_3521 ENOG4105CJR Integral membrane protein (MviN Alide2_3522 ENOG41082GY Binds directly to 16S ribosomal RNA (By similarity) Alide2_3523 ENOG4108VKG metal-dependent hydrolase Alide2_3525 ENOG4105E5H Transposase Alide2_3529 ENOG4105J1P transposase, IS3 IS911 family protein Alide2_3531 ENOG4108Z9W Outer membrane porin Alide2_3537 ENOG4105JSC dimethylmenaquinone methyltransferase Alide2_3539 ENOG4105C8Y Acetylornithine aminotransferase Alide2_3540 ENOG4105DBV ornithine carbamoyltransferase Alide2_3543 ENOG4105PI0 Ferredoxin Alide2_3545 ENOG4105CE1 Ferrous iron transport protein b Alide2_3548 ENOG4107VWA Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation (By similarity) Alide2_3550 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component Alide2_3551 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component Alide2_3552 ENOG4105C3U ABC transporter Alide2_3553 ENOG4108JQ7 (ABC) transporter Alide2_3554 ENOG4108J59 Extracellular solute-binding protein, family 5 Alide2_3556 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) Alide2_3558 ENOG4108N16 Negative regulator of allantoin and glyoxylate utilization operons. Binds to the gcl promoter and to the allS- allA intergenic region Alide2_3559 ENOG4106TNF Periplasmic binding protein Alide2_3560 ENOG4105E5Q amino acid AbC transporter Alide2_3561 ENOG4105CDA abc transporter atp-binding protein Alide2_3562 ENOG4105CJP fad dependent oxidoreductase Alide2_3566 ENOG4105UIB (ABC) transporter Alide2_3567 ENOG4105C2J ABC transporter Alide2_3572 ENOG4108Z9W Outer membrane porin Alide2_3573 ENOG4105K59 histidine triad (HIT) protein Alide2_3574 ENOG4105C5I Dehydrogenase Alide2_3575 ENOG4105CZQ inner membrane transport protein YdhC Alide2_3576 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) Alide2_3577 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) Alide2_3578 ENOG4105VN1 Heat shock protein Alide2_3583 ENOG4105C32 Amino acid ABC transporter (Permease) Alide2_3586 ENOG4108IV0 ABC, transporter Alide2_3587 ENOG4105C0Z ABC transporter Alide2_3588 ENOG4105F4R Transcriptional regulator mode Alide2_3589 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein Alide2_3590 ENOG4105E0C molybdate abc transporter Alide2_3591 ENOG4105CGB Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity) Alide2_3594 ENOG4108JJB ABC transporter Alide2_3596 ENOG4105F4R Transcriptional regulator mode Alide2_3597 ENOG4107RZC phospholipase d Alide2_3598 ENOG4105CEY Amp-dependent synthetase and ligase Alide2_3603 ENOG41084M5 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) Alide2_3605 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F Alide2_3606 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase Alide2_3607 ENOG4108KB2 LysR family Transcriptional regulator Alide2_3609 ENOG4108V1T peptidylprolyl cis-trans isomerase Alide2_3610 ENOG4105CBM Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) Alide2_3611 ENOG4108NVM synthesis repressor PhaR Alide2_3612 ENOG4105VFU Rna-binding protein Alide2_3614 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) Alide2_3616 ENOG4105DTD Dehydrogenase Alide2_3618 ENOG4105DPZ Two component transcriptional regulator (Winged helix family Alide2_3619 ENOG4105E0F Histidine kinase Alide2_3620 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) Alide2_3621 ENOG4108ECM Bifunctional enzyme that catalyzes the formation of 4- diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl- D-erythritol 4-phosphate (MEP) (IspD), and catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2- phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4- cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF) (By similarity) Alide2_3622 ENOG4108JA2 transcriptioN-repair coupling factor Alide2_3624 ENOG4107XGZ Hydrolase Alide2_3625 ENOG4105EAC phosphoserine phosphatase Alide2_3626 ENOG4108NEV two component transcriptional regulator, LytTR family Alide2_3628 ENOG4105CDZ Carboxymethylenebutenolidase (EC 3.1.1.45) Alide2_3629 ENOG4105E39 Enoyl-CoA hydratase Alide2_3630 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F Alide2_3632 ENOG4105DND Transcriptional regulator Alide2_3635 ENOG4105CHR reductase Alide2_3636 ENOG4105DUM transcriptional regulator, lysR family Alide2_3637 ENOG4105C2M dna polymerase I Alide2_3640 ENOG4105CUV Homoserine Kinase Alide2_3644 ENOG4105C4R Atp-dependent dna helicase Alide2_3645 ENOG4107SJ1 Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (By similarity) Alide2_3650 ENOG4105D05 Receptor Alide2_3652 ENOG4108ETV ABC transporter Alide2_3659 ENOG4105C2C drug resistance transporter, Bcr CflA Alide2_3664 ENOG4107QNJ CoA-transferase subunit B Alide2_3665 ENOG4105NN7 muconolactone delta-isomerase Alide2_3669 ENOG4105BZU Histidine kinase Alide2_3670 ENOG4105C1J atp-dependent rna helicase Alide2_3672 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) Alide2_3673 ENOG4105D0M Protease HtpX homolog Alide2_3674 ENOG41090A4 Pterin carbinolamine dehydratase Alide2_3675 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) Alide2_3676 ENOG4105CHH sulfate transporter Alide2_3677 ENOG4105CIH Imidazole acetol-phosphate transaminase Alide2_3678 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) Alide2_3679 ENOG4105P8F nudix hydrolase Alide2_3680 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) Alide2_3681 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) Alide2_3682 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) Alide2_3683 ENOG4105K5M 30s ribosomal protein S16 Alide2_3686 ENOG4107QXV Phosphate transporter Alide2_3687 ENOG4107GRR phosphate transport regulator Alide2_3690 ENOG4108IV0 ABC, transporter Alide2_3691 ENOG4105C0Z ABC transporter Alide2_3692 ENOG4105CF8 branched-chain amino acid ABC transporter, permease Alide2_3693 ENOG4105C32 Amino acid ABC transporter (Permease) Alide2_3694 ENOG4105D1H recombination factor protein RarA Alide2_3697 ENOG4105C0H protease Alide2_3702 ENOG4105CMM transposase Alide2_3707 ENOG4108RG0 uracil-dna glycosylase Alide2_3708 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase Alide2_3709 ENOG4107Y7W Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity) Alide2_3710 ENOG4105CNU cell division protein FtsK Alide2_3711 ENOG4105C3M thioredoxin reductase Alide2_3712 ENOG4105KDC 50s ribosomal protein l28 Alide2_3713 ENOG4105W0E 50S ribosomal protein L33 Alide2_3715 ENOG4108V3E phosphoribosylglycinamide formyltransferase Alide2_3716 ENOG4108YXG UPF0502 protein Alide2_3717 ENOG4105X7H acyl-CoA dehydrogenase Alide2_3718 ENOG4105C1G acyl-Coa dehydrogenase Alide2_3720 ENOG4105DTN riboflavin biosynthesis protein ribF Alide2_3721 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) Alide2_3722 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) Alide2_3723 ENOG4105ETE Transcriptional regulator (LacI family Alide2_3724 ENOG4107QKW extracellular solute-binding protein family 1 Alide2_3725 ENOG4108I5D sulfate abc transporter Alide2_3726 ENOG4108EG7 Binding-protein-dependent transport systems, inner membrane component Alide2_3727 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) Alide2_3728 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) Alide2_3729 ENOG4105EAM Na Pi-cotransporter Alide2_3730 ENOG4105DHU Bile acid Alide2_3731 ENOG4108M0I Transcriptional regulator Alide2_3733 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein Alide2_3734 ENOG4108IPJ Membrane Alide2_3735 ENOG4105BZU Histidine kinase Alide2_3737 ENOG4105CHR reductase Alide2_3740 ENOG4107QHF type ii secretion system protein e Alide2_3741 ENOG4105I7M spermidine synthase Alide2_3743 ENOG4105EYA deoxyribonuclease Alide2_3745 ENOG41080HT Transcriptional regulator, arsr family Alide2_3747 ENOG4105C0H protease Alide2_3748 ENOG4105C7R Atpase associated with various cellular activities aaa_3 Alide2_3750 ENOG4107QVM von Willebrand factor, type A Alide2_3751 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) Alide2_3752 ENOG4108IJ7 Glycine betaine Alide2_3753 ENOG4108HQS Glycine betaine Alide2_3754 ENOG4105GIJ Glycine betaine Alide2_3755 ENOG4105IJJ transcriptional regulator, crp fnr family Alide2_3758 ENOG4105NVB glycoside hydrolase, family 19 Alide2_3759 ENOG4105CMS peptidase U62, modulator of DNA gyrase Alide2_3760 ENOG4105N42 UPF0307 protein Alide2_3761 ENOG4108RIR Molybdenum cofactor biosynthesis protein Alide2_3762 ENOG4105CPQ Dehydrogenase Alide2_3764 ENOG4105D7W serine acetyltransferase Alide2_3766 ENOG4105ECY inositol monophosphatase Alide2_3768 ENOG4105CG6 trap dicarboxylate transporter dctm subunit Alide2_3769 ENOG4107QRT dEAD DEAH box helicase Alide2_3770 ENOG4105CH5 extracellular solute-binding protein, family 7 Alide2_3771 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) Alide2_3773 ENOG41086K9 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) Alide2_3776 ENOG4105KHC sulfurtransferase Alide2_3778 ENOG4108EC8 DNA internalization-related competence protein ComEC Alide2_3780 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) Alide2_3781 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) Alide2_3785 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) Alide2_3786 ENOG4105GJM (LipO)protein Alide2_3788 ENOG4105EZE Cupin 4 family protein Alide2_3789 ENOG4108YZY peptidylprolyl cis-trans isomerase Alide2_3790 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) Alide2_3792 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase Alide2_3793 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) Alide2_3794 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase Alide2_3796 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) Alide2_3797 ENOG4105XX3 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) Alide2_3798 ENOG4108JEH abc transporter atp-binding protein Alide2_3800 ENOG4105DSP amino acid AbC transporter Alide2_3801 ENOG4105E89 ABC transporter Alide2_3802 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) Alide2_3803 ENOG4108Z0R Transferase Alide2_3804 ENOG4105ED9 Protein of unknown function (DUF455) Alide2_3805 ENOG4105D58 Diguanylate phosphodiesterase Alide2_3806 ENOG4105D58 Diguanylate phosphodiesterase Alide2_3808 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor Alide2_3810 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) Alide2_3812 ENOG4105CMM transposase Alide2_3814 ENOG4108VKV Monofunctional biosynthetic peptidoglycan transglycosylase Alide2_3815 ENOG4105E2X shikimate dehydrogenase Alide2_3818 ENOG4105EMN RNA polymerase sigma factor Alide2_3820 ENOG4105XUA cytochrome c Alide2_3822 ENOG4105IPS esterase Alide2_3823 ENOG4105CNI cell division protein FtsW Alide2_3824 ENOG4105D1U peptidase U62 modulator of DNA gyrase Alide2_3825 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) Alide2_3827 ENOG4105DFU Cell wall formation (By similarity) Alide2_3829 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen Alide2_3830 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein Alide2_3831 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase Alide2_3832 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) Alide2_3836 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) Alide2_3837 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) Alide2_3839 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family Alide2_3840 ENOG4107TUY Histidine kinase Alide2_3842 ENOG4105CRE cytochrome C Alide2_3843 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY Alide2_3844 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) Alide2_3848 ENOG4105T95 Thiol disulfide interChange protein Alide2_3849 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family Alide2_3850 ENOG4105C3G gtp-binding protein Alide2_3853 ENOG4105CMM transposase Alide2_3856 ENOG4105E5H Transposase Alide2_3860 ENOG4105CSU acyl-Coa dehydrogenase Alide2_3862 ENOG4105C2C drug resistance transporter, Bcr CflA Alide2_3865 ENOG4105DE9 3-keto-5-aminohexanoate cleavage enzyme Alide2_3866 ENOG4105E2B Taurine dioxygenase Alide2_3867 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein Alide2_3870 ENOG4105WH1 Two component transcriptional regulator luxr family Alide2_3872 ENOG4105D25 secreted protein Alide2_3875 ENOG4105HMI Membrane Alide2_3877 ENOG4105W39 Membrane Alide2_3878 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) Alide2_3879 ENOG4105VY0 Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters (By similarity) Alide2_3880 ENOG4105DC1 bifunctional purine biosynthesis protein purh Alide2_3883 ENOG4105VCQ rubredoxin Alide2_3884 ENOG4108UNF response regulator Alide2_3885 ENOG4105M3Z response regulator Alide2_3887 ENOG4105C8Q Methyl-accepting chemotaxis Alide2_3888 ENOG4105CBS Chea signal transduction histidine kinase Alide2_3889 ENOG4108UJU UPF0301 protein Alide2_3890 ENOG4107Y66 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) Alide2_3891 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) Alide2_3892 ENOG4105CXT aspartate transcarbamylase Alide2_3893 ENOG4105CD3 dihydroorotase Alide2_3895 ENOG4108UCS ABC, transporter Alide2_3896 ENOG4107QVT Binding-protein-dependent transport systems, inner membrane component Alide2_3898 ENOG4105C0H protease Alide2_3899 ENOG4105XJC Two component transcriptional regulator (Winged helix family Alide2_3900 ENOG4105DHQ Histidine kinase Alide2_3902 ENOG4108EX3 reductase Alide2_3903 ENOG4108KAG Cytochrome C oxidase, subunit I Alide2_3907 ENOG4108YJ5 Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) Alide2_3908 ENOG4107RQ2 Cytochrome c oxidase, subunit I Alide2_3909 ENOG4105NAA Cytochrome C oxidase, subunit II Alide2_3918 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F Alide2_3919 ENOG4105CMD Transcriptional regulator, GntR family Alide2_3922 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) Alide2_3923 ENOG4106RE7 Cytochrome Alide2_3926 ENOG4107HP6 Transcriptional regulator Alide2_3928 ENOG4107QNJ CoA-transferase subunit B Alide2_3929 ENOG4105CHU acetyl-coa acetyltransferase Alide2_3933 ENOG41064T2 transcriptional regulator, lysR family Alide2_3935 ENOG4105CH2 amidohydrolase Alide2_3937 ENOG4105JN3 extra-cytoplasmic solute receptor family protein Alide2_3941 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) Alide2_3942 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) Alide2_3944 ENOG4105FDP GntR family transcriptional regulator Alide2_3945 ENOG4105CKD glutathione-regulated potassium-efflux system protein Alide2_3949 ENOG4105EXG Transcriptional regulator Alide2_3950 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) Alide2_3951 ENOG41081UC Inherit from COG: Competence protein Alide2_3952 ENOG4106T9E Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) Alide2_3953 ENOG4105CV4 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity) Alide2_3954 ENOG4105BZ9 Cytochrome C oxidase, subunit I Alide2_3956 ENOG4105FT1 Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I (By similarity) Alide2_3958 ENOG4107QS1 Cytochrome C Oxidase, Subunit III Alide2_3963 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) Alide2_3966 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) Alide2_3967 ENOG4105E5H Transposase Alide2_3970 ENOG4105CMM transposase Alide2_3975 ENOG4105CSA Coproporphyrinogen iii oxidase Alide2_3976 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) Alide2_3980 ENOG4105DSJ YicC domain protein Alide2_3994 ENOG4105DHM ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis (By similarity) Alide2_4000 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) Alide2_4001 ENOG4105VFG Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) Alide2_4002 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) Alide2_4003 ENOG4108RRZ Transcription elongation factor GreB Alide2_4005 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) Alide2_4006 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) Alide2_4008 ENOG4105CP7 Triose-phosphate isomerase Alide2_4009 ENOG4107EJC Preprotein translocase subunit SecG Alide2_4010 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain Alide2_4011 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) Alide2_4012 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain Alide2_4013 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) Alide2_4015 ENOG4107QIZ NADH dehydrogenase Alide2_4016 ENOG4108IEH NADH dehydrogenase subunit g Alide2_4017 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) Alide2_4018 ENOG4105P3U NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) Alide2_4019 ENOG4105DF2 NADH dehydrogenase subunit j Alide2_4020 ENOG4105M5H NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) Alide2_4022 ENOG4105C8S subunit m Alide2_4023 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) Alide2_4027 ENOG4105D82 Glutamate dehydrogenase Alide2_4028 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) Alide2_4030 ENOG4105DQR SNARE associated Golgi Alide2_4031 ENOG4107QUY Guanine deaminase Alide2_4032 ENOG4105C7N Xanthine uracil vitamin C permease Alide2_4034 ENOG4105C7W Xanthine dehydrogenase Alide2_4035 ENOG4108HR6 Dehydrogenase Alide2_4037 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase Alide2_4038 ENOG4105K8N protein family UPF0079, ATPase Alide2_4039 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) Alide2_4042 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) Alide2_4044 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) Alide2_4046 ENOG4105C7C involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) Alide2_4049 ENOG4105CEY Amp-dependent synthetase and ligase Alide2_4050 ENOG4105CHR reductase Alide2_4052 ENOG4105JN3 extra-cytoplasmic solute receptor family protein Alide2_4054 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) Alide2_4055 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) Alide2_4056 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) Alide2_4057 ENOG4105CPF Cell wall formation (By similarity) Alide2_4058 ENOG4105DFU Cell wall formation (By similarity) Alide2_4059 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) Alide2_4060 ENOG4105CNI cell division protein FtsW Alide2_4061 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) Alide2_4062 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) Alide2_4063 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) Alide2_4064 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) Alide2_4065 ENOG4105CJN penicillin-binding protein Alide2_4067 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) Alide2_4068 ENOG4108V6E Cell division protein mraZ Alide2_4069 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) Alide2_4070 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) Alide2_4072 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters Alide2_4073 ENOG4105CKI cobalamin synthesis protein Alide2_4075 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family Alide2_4076 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) Alide2_4078 ENOG4105BZU Histidine kinase Alide2_4079 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) Alide2_4080 ENOG4105CK6 Two component transcriptional regulator (Winged helix family Alide2_4081 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase Alide2_4083 ENOG4105BZU Histidine kinase Alide2_4084 ENOG4105C8Q Methyl-accepting chemotaxis Alide2_4085 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) Alide2_4087 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) Alide2_4089 ENOG4105I08 Pseudouridine synthase Alide2_4093 ENOG4105DZ0 fad dependent oxidoreductase Alide2_4095 ENOG4105EGI Transcriptional regulator Alide2_4096 ENOG4105CI0 Citrate lyase Alide2_4099 ENOG4105GAK amidohydrolase 2 Alide2_4101 ENOG4108SY4 MarR family Transcriptional regulator Alide2_4102 ENOG4105CHR reductase Alide2_4103 ENOG4108IPT Naphthoate synthase Alide2_4105 ENOG4105CEY Amp-dependent synthetase and ligase Alide2_4106 ENOG4105C10 Electron transfer flavoprotein Alide2_4107 ENOG4105BZJ Electron transfer flavoprotein Alide2_4108 ENOG4105EA8 2-Nitropropane dioxygenase Alide2_4110 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F Alide2_4112 ENOG4108UKI Enoyl-CoA hydratase Alide2_4113 ENOG4105C1G acyl-Coa dehydrogenase Alide2_4114 ENOG4105CC9 acyl-Coa dehydrogenase Alide2_4115 ENOG4105CHU acetyl-coa acetyltransferase Alide2_4116 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase Alide2_4117 ENOG4105CBN LysR family transcriptional regulator Alide2_4120 ENOG4105J1P transposase, IS3 IS911 family protein Alide2_4123 ENOG4105D0M Protease HtpX homolog Alide2_4125 ENOG4105EKE dihydroorotase Alide2_4127 ENOG4105K78 MarR family Transcriptional regulator Alide2_4128 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) Alide2_4129 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) Alide2_4130 ENOG4105CP9 extracellular ligand-binding receptor Alide2_4132 ENOG4108Z9W Outer membrane porin Alide2_4133 ENOG4105CSH Transporter Alide2_4141 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase Alide2_4142 ENOG4105JPG D-isomer specific 2-hydroxyacid dehydrogenase Alide2_4146 ENOG4107QX3 carboxylase Alide2_4147 ENOG4105CEY Amp-dependent synthetase and ligase Alide2_4150 ENOG4105CZ6 Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine (By similarity) Alide2_4151 ENOG4105CP9 extracellular ligand-binding receptor Alide2_4152 ENOG4105C32 Amino acid ABC transporter (Permease) Alide2_4153 ENOG4105C0Z ABC transporter Alide2_4154 ENOG4108IV0 ABC, transporter Alide2_4155 ENOG4105CZ6 Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine (By similarity) Alide2_4156 ENOG4105CEY Amp-dependent synthetase and ligase Alide2_4157 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family Alide2_4159 ENOG4107UB3 HAD-superfamily hydrolase subfamily IA variant 3 Alide2_4161 ENOG4105DEF Extracellular solute-binding protein, family 5 Alide2_4163 ENOG4105BZU Histidine kinase Alide2_4164 ENOG4105K5B UPF0225 protein Alide2_4174 ENOG4105C1G acyl-Coa dehydrogenase Alide2_4176 ENOG4105CHU acetyl-coa acetyltransferase Alide2_4177 ENOG4105VS7 Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation (By similarity) Alide2_4178 ENOG41077A9 carbonic anhydrase Alide2_4179 ENOG4105C1G acyl-Coa dehydrogenase Alide2_4180 ENOG4108Z6Z Transcriptional regulator Alide2_4181 ENOG4105C5H ABC transporter Alide2_4182 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) Alide2_4183 ENOG4108Z4W Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis (By similarity) Alide2_4184 ENOG4105BZU Histidine kinase Alide2_4185 ENOG4108V3W Chemotaxis protein, CheW Alide2_4186 ENOG4105CBS Chea signal transduction histidine kinase Alide2_4187 ENOG4107YTP response regulator receiver protein Alide2_4190 ENOG4105WH1 Two component transcriptional regulator luxr family Alide2_4191 ENOG4105D19 Role in flagellar biosynthesis (By similarity) Alide2_4192 ENOG4105VS8 Flagellar biosynthetic protein fliq Alide2_4193 ENOG4105CN7 Flagellar biosynthetic protein FliP Alide2_4195 ENOG4105DD5 Flagellar motor switch protein Alide2_4196 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) Alide2_4200 ENOG4108JIR Flagellum-specific ATP synthase Alide2_4202 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) Alide2_4203 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) Alide2_4204 ENOG4105VQ0 flagellar hook-basal body complex protein fliE Alide2_4207 ENOG4105DTS flagellar hook-associated Alide2_4209 ENOG4105I03 Flagellin Alide2_4210 ENOG4105CTC Lipopolysaccharide biosynthesis protein-like protein Alide2_4211 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) Alide2_4212 ENOG4107RD7 Flagellar Motor Protein, MotA Alide2_4213 ENOG4105ER2 Ompa motb domain protein Alide2_4214 ENOG4108VYJ response regulator receiver protein Alide2_4215 ENOG4108KCC Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P) (By similarity) Alide2_4216 ENOG4105D00 flagellar biosynthetic protein flhB Alide2_4217 ENOG4105D7B Flagellar biosynthesis protein flha Alide2_4218 ENOG4105FZW flagellar biosynthesis regulator FlhF Alide2_4220 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) Alide2_4223 ENOG4105CKS Flagella basal body P-ring formation protein flgA Alide2_4224 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) Alide2_4225 ENOG4108ZC9 flagellar basal-body rod protein flgc Alide2_4226 ENOG4105W00 Flagellar hook capping protein Alide2_4227 ENOG4105BZE flagellar hook protein, FlgE Alide2_4228 ENOG4108KPB Flagellar basal-body rod protein FlgF Alide2_4229 ENOG4105CGA flagellar basal-body rod protein FlgG Alide2_4230 ENOG4107W7W Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) Alide2_4231 ENOG4105D92 Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) Alide2_4232 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj Alide2_4234 ENOG4105DTJ flagellar hook-associated protein Alide2_4236 ENOG4105EA8 2-Nitropropane dioxygenase Alide2_4237 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family Alide2_4239 ENOG4105T38 integral membrane protein Alide2_4240 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family Alide2_4241 ENOG4105JAB phenazine biosynthesis protein, phzf family Alide2_4242 ENOG4105C7B Threonine dehydratase Alide2_4254 ENOG4108IFH alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen Alide2_4257 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) Alide2_4258 ENOG4105C25 Primosomal protein n' Alide2_4259 ENOG4105CHU acetyl-coa acetyltransferase Alide2_4260 ENOG4108UKI Enoyl-CoA hydratase Alide2_4261 ENOG4108IQE Amp-dependent synthetase and ligase Alide2_4262 ENOG4108IV0 ABC, transporter Alide2_4266 ENOG4105C0Z ABC transporter Alide2_4268 ENOG4105RK9 auxin efflux carrier Alide2_4269 ENOG4105C4R Atp-dependent dna helicase Alide2_4271 ENOG4105HDD phospholipase Alide2_4272 ENOG4105E6M Sulphatase-modifying factor protein Alide2_4273 ENOG4107QRH Arylsulfatase (Ec 3.1.6.1) Alide2_4276 ENOG4105ERH Fumarylacetoacetate hydrolase Alide2_4277 ENOG4108Z9W Outer membrane porin Alide2_4278 ENOG4108PVQ transcriptional regulator Alide2_4280 ENOG4107YZX Universal stress protein Alide2_4281 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) Alide2_4287 ENOG4105JSC dimethylmenaquinone methyltransferase Alide2_4289 ENOG4105CEY Amp-dependent synthetase and ligase Alide2_4290 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) Alide2_4291 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) Alide2_4296 ENOG4105E1J oxidoreductase Alide2_4301 ENOG4105M2Z protein tyrosine serine phosphatase Alide2_4309 ENOG4105VNT transposase (IS4 family) protein Alide2_4314 ENOG4105J1P transposase, IS3 IS911 family protein Alide2_4318 ENOG4105DAB fumarate reductase succinate dehydrogenase flavoprotein domain protein Alide2_4327 ENOG4107P0T Selenium-dependent molybdenum hydroxylase system protein, YqeB family Alide2_4334 ENOG4105CSU acyl-Coa dehydrogenase Alide2_4335 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase Alide2_4336 ENOG4105CHU acetyl-coa acetyltransferase Alide2_4337 ENOG4105CHR reductase Alide2_4338 ENOG4105CEY Amp-dependent synthetase and ligase Alide2_4339 ENOG4105C2J ABC transporter Alide2_4340 ENOG4105CNN ABC, transporter Alide2_4341 ENOG4105CNN ABC, transporter Alide2_4342 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator Alide2_4351 ENOG4108ZT0 50S ribosomal protein l17 Alide2_4352 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) Alide2_4353 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) Alide2_4354 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) Alide2_4355 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits Alide2_4357 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) Alide2_4358 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) Alide2_4359 ENOG4105VPB 50S ribosomal protein L30 Alide2_4360 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) Alide2_4361 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) Alide2_4362 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) Alide2_4363 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) Alide2_4364 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) Alide2_4365 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits Alide2_4366 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) Alide2_4367 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) Alide2_4368 ENOG4105C6V Glycerol-3-phosphate dehydrogenase Alide2_4369 ENOG4105E98 transcriptional regulator DeoR family Alide2_4370 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) Alide2_4371 ENOG4105II7 pyrroline-5-carboxylate reductase Alide2_4373 ENOG4105C4G Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity) Alide2_4376 ENOG4105C5Q Transcriptional regulator Alide2_4377 ENOG4105CB5 ATP-dependent DNA helicase recG Alide2_4378 ENOG4105CPI Metal Dependent Phosphohydrolase Alide2_4379 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) Alide2_4381 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) Alide2_4383 ENOG4105F04 LysR family Transcriptional regulator Alide2_4384 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) Alide2_4385 ENOG4105DK0 Indole-3-glycerol phosphate synthase Alide2_4387 ENOG4108I0Q anthranilate phosphoribosyltransferase Alide2_4388 ENOG4105DDQ anthranilate synthase Alide2_4390 ENOG4105J1P transposase, IS3 IS911 family protein Alide2_4396 ENOG4105C8Q Methyl-accepting chemotaxis Alide2_4397 ENOG4105BZU Histidine kinase Alide2_4398 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) Alide2_4400 ENOG4105DJV ribulose-phosphate 3-epimerase Alide2_4401 ENOG4105NWN ApaG protein Alide2_4404 ENOG4106KXD ATP-dependent carboxylate-amine ligase (By similarity) Alide2_4405 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) Alide2_4408 ENOG4105WMT general secretion pathway protein h Alide2_4413 ENOG4108IG5 Transcriptional regulator Alide2_4414 ENOG4105D1N poly(r)-hydroxyalkanoic acid synthase, class Alide2_4415 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH Alide2_4416 ENOG4105ENJ RND efflux system, outer membrane lipoprotein Alide2_4417 ENOG4105D0S secretion protein (HlyD Alide2_4418 ENOG4105CJ1 ABC, transporter Alide2_4419 ENOG4105CMI transporter Alide2_4421 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) Alide2_4422 ENOG4108ZAI phosphatidylglycerophosphatase a Alide2_4424 ENOG4105C8Q Methyl-accepting chemotaxis Alide2_4425 ENOG4105BZU Histidine kinase Alide2_4428 ENOG4106RHG Yeca family Alide2_4431 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) Alide2_4432 ENOG4105C8Q Methyl-accepting chemotaxis Alide2_4434 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) Alide2_4435 ENOG4108IUZ ABC transporter Alide2_4437 ENOG4108Z33 Thiol disulfide Interchange Protein Alide2_4439 ENOG4105C75 arginyL-tRNA synthetase Alide2_4442 ENOG4105CK2 sodium dicarboxylate symporter Alide2_4446 ENOG4107QP3 malate synthase g Alide2_4448 ENOG41084KP 4-oxalocrotonate tautomerase Alide2_4450 ENOG4105E7A Glutamine amidotransferase Alide2_4451 ENOG4105D7Z glutathione synthase Alide2_4452 ENOG4105DKK Benzoate Alide2_4453 ENOG4105DFH Transport of potassium into the cell (By similarity) Alide2_4455 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) Alide2_4456 ENOG4105C1A potassium transporter peripheral membrane Alide2_4457 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) Alide2_4462 ENOG4105DJF DNA polymerase III, delta' subunit Alide2_4464 ENOG4105C8T Leucyl-tRNA synthetase Alide2_4465 ENOG4105CUY Mechanosensitive ion channel Alide2_4466 ENOG4105C26 Dehydrogenase Alide2_4468 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family Alide2_4470 ENOG4105BZU Histidine kinase Alide2_4471 ENOG4105SG9 biopolymer transport protein, ExbD Alide2_4473 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) Alide2_4474 ENOG4105YRI Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) Alide2_4475 ENOG41090R7 Ferric uptake Alide2_4476 ENOG4105D1C Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) Alide2_4477 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN Alide2_4478 ENOG41080QH sigma 54 modulation protein ribosomal protein S30EA Alide2_4479 ENOG4105C8V SAICAR synthetase Alide2_4480 ENOG4105K63 Thioredoxin Alide2_4481 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) Alide2_4482 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit Alide2_4483 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) Alide2_4485 ENOG4105EIF outer membrane protein W Alide2_4487 ENOG4106HRJ d-alanyl-d-alanine carboxypeptidase Alide2_4488 ENOG41072GX Peptidase M22 Glycoprotease Alide2_4491 ENOG4107QUT magnesium and cobalt transport protein CorA Alide2_4495 ENOG4105CEY Amp-dependent synthetase and ligase Alide2_4496 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) Alide2_4497 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) Alide2_4499 ENOG4105D2N Aldolase Alide2_4500 ENOG4105CA9 Pyruvate kinase Alide2_4501 ENOG4107RAQ aminopeptidase Alide2_4502 ENOG4105E39 Enoyl-CoA hydratase Alide2_4508 ENOG4105GZI Transcriptional regulator Alide2_4509 ENOG4108S0S Nucleotidyl transferase Alide2_4510 ENOG4105CV1 Transketolase (EC 2.2.1.1) Alide2_4511 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase Alide2_4514 ENOG4105DND Transcriptional regulator Alide2_4515 ENOG4105GAK amidohydrolase 2 Alide2_4526 ENOG4105EMY transcriptional regulator Alide2_4528 ENOG4107JEE Short-chain dehydrogenase reductase Sdr Alide2_4530 ENOG4106IUH DTW domain containing protein Alide2_4535 ENOG4105CD5 CoA-binding domain protein Alide2_4536 ENOG4105CYM Glutathione S-transferase Alide2_4537 ENOG4108KEZ Dehydrogenase Alide2_4539 ENOG4105C9U ATP-dependent DNA helicase RecQ Alide2_4543 ENOG4105CB2 alcohol dehydrogenase Alide2_4545 ENOG410900P UPF0336 protein Alide2_4547 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) Alide2_4548 ENOG4108SY4 MarR family Transcriptional regulator Alide2_4553 ENOG4105DHQ Histidine kinase Alide2_4558 ENOG4105C4Y ABC transporter Alide2_4563 ENOG4105CJP fad dependent oxidoreductase Alide2_4564 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) Alide2_4565 ENOG4105MWK D-amino acid dehydrogenase, small subunit Alide2_4566 ENOG4105EW9 transcriptional regulator AsnC family Alide2_4568 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) Alide2_4569 ENOG4108004 Modulates RecA activity (By similarity) Alide2_4571 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) Alide2_4572 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) Alide2_4573 ENOG4105VIE preprotein translocase, subunit YajC Alide2_4575 ENOG4105F7P transcriptional regulator AsnC family Alide2_4576 ENOG4107SFI Major Facilitator superfamily Alide2_4577 ENOG4105CA3 membrane-bound lytic murein transglycosylase Alide2_4579 ENOG4108ZXC Two component transcriptional regulator, luxr family Alide2_4580 ENOG4105BZU Histidine kinase Alide2_4583 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) Alide2_4586 ENOG4108U78 Glutathione S-transferase Alide2_4587 ENOG4107QTF adenylosuccinate lyase Alide2_4588 ENOG4108VWS Yaeq family Alide2_4591 ENOG4108ZCF integral membrane protein Alide2_4593 ENOG4107RSM transcriptional regulator Alide2_4595 ENOG41086DT Membrane protein of unknown function Alide2_4596 ENOG4105ERG peptidase m48, ste24p Alide2_4597 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) Alide2_4599 ENOG4105YWY Alide2_4601 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) Alide2_4602 ENOG4108UW8 fha domain-containing protein Alide2_4604 ENOG4108ZCF integral membrane protein Alide2_4605 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha Alide2_4606 ENOG4105CMV Succinyl-CoA synthetase subunit beta Alide2_4607 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase Alide2_4608 ENOG4105C79 DNA protecting protein DprA Alide2_4610 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) Alide2_4612 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) Alide2_4615 ENOG4105BZA Phosphoglycerate kinase Alide2_4618 ENOG4108Q5Y Membrane Alide2_4619 ENOG4105SKN orotidine 5''-phosphate decarboxylase Alide2_4623 ENOG4105C8Q Methyl-accepting chemotaxis Alide2_4625 ENOG4107RDB Major Facilitator Alide2_4627 ENOG4105DAA L-lactate Alide2_4628 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) Alide2_4629 ENOG4105F04 LysR family Transcriptional regulator Alide2_4630 ENOG4105C7F AcnD-accessory protein PrpF Alide2_4632 ENOG4108Z9W Outer membrane porin Alide2_4635 ENOG41079YP Citrate utilization protein b Alide2_4637 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family Alide2_4638 ENOG4107QX3 carboxylase Alide2_4639 ENOG4105JN3 extra-cytoplasmic solute receptor family protein Alide2_4641 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase Alide2_4642 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit Alide2_4650 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F Alide2_4652 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) Alide2_4655 ENOG4105E0F Histidine kinase Alide2_4656 ENOG4105XJC Two component transcriptional regulator (Winged helix family Alide2_4659 ENOG4105E3J oxidoreductase Alide2_4660 ENOG4108VKM cytochrome b561 Alide2_4664 ENOG4105CJ2 (LipO)protein Alide2_4667 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic Alide2_4672 ENOG4105C1G acyl-Coa dehydrogenase Alide2_4673 ENOG4107258 Transcriptional regulator Alide2_4674 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F Alide2_4677 ENOG4105C1G acyl-Coa dehydrogenase Alide2_4680 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F Alide2_4692 ENOG4105EVZ LysR family transcriptional regulator Alide2_4693 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) Alide2_4694 ENOG4105C26 Dehydrogenase Alide2_4695 ENOG4105BZU Histidine kinase Alide2_4696 ENOG4108PVQ transcriptional regulator Alide2_4698 ENOG4105C32 Amino acid ABC transporter (Permease) Alide2_4699 ENOG4105CF8 branched-chain amino acid ABC transporter, permease Alide2_4700 ENOG4105C0Z ABC transporter Alide2_4701 ENOG4108IV0 ABC, transporter Alide2_4702 ENOG4105CE7 Amidase, hydantoinase carbamoylase family Alide2_4704 ENOG4105C6K Malic enzyme Alide2_4707 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) Alide2_4708 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) Alide2_4709 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) Alide2_4710 ENOG4105EHM Aminoglycoside phosphotransferase Alide2_4711 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) Alide2_4714 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) Alide2_4716 ENOG4105BZU Histidine kinase Alide2_4717 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) Alide2_4718 ENOG4105DWV Homoserine O-trans-acetylase Alide2_4720 ENOG4105VFU Rna-binding protein Alide2_4721 ENOG4105VFU Rna-binding protein Alide2_4722 ENOG4107FW0 short-chain dehydrogenase reductase Alide2_4724 ENOG4108Z4R 3-deoxy-d-manno-octulosonate 8-phosphate phosphatase Alide2_4725 ENOG4105C2X Arabinose 5-phosphate isomerase Alide2_4727 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) Alide2_4730 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) Alide2_4731 ENOG4107RP9 extracellular solute-binding protein, family 3 Alide2_4732 ENOG4105MWK D-amino acid dehydrogenase, small subunit Alide2_4737 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component Alide2_4738 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component Alide2_4740 ENOG4108JQ6 ABC transporter Alide2_4741 ENOG4105D44 asparaginase Alide2_4745 ENOG4105DEF Extracellular solute-binding protein, family 5 Alide2_4746 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins Alide2_4747 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) Alide2_4748 ENOG4105X5M RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) Alide2_4749 ENOG4105VG0 50S ribosomal protein l34 Alide2_4757 ENOG4105BZU Histidine kinase Alide2_4758 ENOG4105WH1 Two component transcriptional regulator luxr family Alide2_4766 ENOG4105T95 Thiol disulfide interChange protein Alide2_4801 ENOG4108R7K Metal Dependent Phosphohydrolase Alide2_4807 ENOG4105FA0 parb-like partition protein Alide2_4809 ENOG4105VUH addiction module killer protein Alide2_4815 ENOG4105DVF Cytosine-specific methyltransferase Alide2_4822 ENOG4108UUM single-stranded DNA-binding protein Alide2_4831 ENOG4105W5Q DNA repair protein (RadC Alide2_4835 ENOG4108C33 Resolvase