locus-tag class description Aaci_0002 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) Aaci_0003 ENOG4105WQ3 Rna-binding protein Aaci_0005 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) Aaci_0006 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) Aaci_0011 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) Aaci_0012 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) Aaci_0013 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) Aaci_0018 ENOG4107Y9E nuclease Aaci_0023 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) Aaci_0027 ENOG4108IJ1 Dehydrogenase Aaci_0032 ENOG4108JQ9 ABC transporter Aaci_0033 ENOG4105DIH basic membrane Aaci_0034 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) Aaci_0039 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) Aaci_0044 ENOG4105EFI regulatoR Aaci_0045 ENOG4105BZU Histidine kinase Aaci_0047 ENOG4108ZUB Lysine exporter protein (Lyse ygga) Aaci_0050 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator Aaci_0051 ENOG4105C0R drug resistance transporter emrb qaca subfamily Aaci_0052 ENOG4107TXC Transcriptional regulator Aaci_0054 ENOG4107GRR phosphate transport regulator Aaci_0055 ENOG4108HMR Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) Aaci_0056 ENOG4105C6V Glycerol-3-phosphate dehydrogenase Aaci_0058 ENOG4105G3Z GntR family transcriptional regulator Aaci_0059 ENOG4105CHR reductase Aaci_0064 ENOG4105BZU Histidine kinase Aaci_0066 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) Aaci_0070 ENOG4107104 thymidine kinase Aaci_0072 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase Aaci_0073 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) Aaci_0074 ENOG4108QXE glycerophosphoryl diester phosphodiesterase Aaci_0076 ENOG4105DRS transport system, permease Aaci_0079 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) Aaci_0080 ENOG4108KN7 Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) Aaci_0082 ENOG4105ECB domain protein Aaci_0083 ENOG4105EEM helicase Aaci_0084 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) Aaci_0085 ENOG4107QYV phosphohexose isomerase Aaci_0086 ENOG4105DKQ ROK family Aaci_0091 ENOG4105EYF MMPL domain protein Aaci_0094 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) Aaci_0096 ENOG4105DT1 RuBisCO catalyzes two reactions the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate Aaci_0097 ENOG4105JAS Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene) (By similarity) Aaci_0098 ENOG4107V49 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) Aaci_0101 ENOG4105CAQ asparagine synthetase Aaci_0103 ENOG4108Z6B deaminase Aaci_0104 ENOG4105BZU Histidine kinase Aaci_0106 ENOG4105C6E dna polymerase iii Aaci_0107 ENOG410816I Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) Aaci_0108 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) Aaci_0109 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) Aaci_0110 ENOG4105DRR Transcriptional regulator, GntR family Aaci_0114 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component Aaci_0116 ENOG41067KS pro-sigma K processing Aaci_0120 ENOG4105CXN decarboxylase Aaci_0121 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) Aaci_0122 ENOG4105X0R protein from nitrogen regulatory protein P-II Aaci_0123 ENOG4107QRG dna polymerase iii Aaci_0124 ENOG4105MA4 psp1 domain protein Aaci_0125 ENOG4105QD5 Involved in initiation control of chromosome replication (By similarity) Aaci_0127 ENOG4105KRN Transcriptional regulator, abrb family Aaci_0129 ENOG4105F8V Hydrolase, tatD family Aaci_0132 ENOG4108IJ6 ABC transporter Aaci_0133 ENOG4108CCU Ribonucleotide-diphosphate reductase subunit beta Aaci_0139 ENOG4107WYG Transcriptional regulator, luxr family Aaci_0142 ENOG4105CEY Amp-dependent synthetase and ligase Aaci_0143 ENOG4105C1G acyl-Coa dehydrogenase Aaci_0144 ENOG4105C1G acyl-Coa dehydrogenase Aaci_0145 ENOG4105E39 Enoyl-CoA hydratase Aaci_0146 ENOG4105CHR reductase Aaci_0147 ENOG4105CHU acetyl-coa acetyltransferase Aaci_0150 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) Aaci_0152 ENOG4105C26 Dehydrogenase Aaci_0153 ENOG4105C0A alcohol dehydrogenase Aaci_0155 ENOG4105C1G acyl-Coa dehydrogenase Aaci_0157 ENOG4105CHR reductase Aaci_0158 ENOG4105C1G acyl-Coa dehydrogenase Aaci_0159 ENOG4105CEY Amp-dependent synthetase and ligase Aaci_0160 ENOG410900P UPF0336 protein Aaci_0165 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) Aaci_0168 ENOG4105XFA sporulation peptidase YabG Aaci_0170 ENOG4105W42 Veg protein Aaci_0173 ENOG4107RRY Cyanophycin synthetase Aaci_0174 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) Aaci_0175 ENOG4105DFT pur operon repressor Aaci_0176 ENOG4105KME endoribonuclease L-psp Aaci_0177 ENOG4105K4W Could be involved in septation (By similarity) Aaci_0178 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) Aaci_0179 ENOG4105C5T Phosphoribosyl pyrophosphate synthase Aaci_0180 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) Aaci_0182 ENOG4108JA2 transcriptioN-repair coupling factor Aaci_0183 ENOG4108M14 stage v sporulation protein t Aaci_0185 ENOG4108IY2 MazG family Aaci_0187 ENOG41082I2 s4 domain protein Aaci_0191 ENOG41060GV RNA binding s1 domain protein Aaci_0194 ENOG4108UK2 deaminase Aaci_0198 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) Aaci_0200 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) Aaci_0203 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase Aaci_0204 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) Aaci_0205 ENOG4105EEI dihydropteroate synthase Aaci_0206 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase Aaci_0208 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) Aaci_0212 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) Aaci_0213 ENOG4105EU0 Major facilitator Superfamily Aaci_0216 ENOG4105CHR reductase Aaci_0217 ENOG4105CHM Aminotransferase Aaci_0218 ENOG4108V3E phosphoribosylglycinamide formyltransferase Aaci_0221 ENOG4105ETD TRANSCRIPTIONal Aaci_0223 ENOG4107SQ3 mannitol-1-phosphate 5-dehydrogenase Aaci_0224 ENOG4105KRI phosphocarrier protein (HPr Aaci_0225 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) Aaci_0226 ENOG4105K6V RNA polymerase Aaci_0231 ENOG4108JJB ABC transporter Aaci_0233 ENOG4105VKD bioY protein Aaci_0234 ENOG4105BZU Histidine kinase Aaci_0237 ENOG41082J7 Rhodanese domain protein Aaci_0240 ENOG4105DTD Dehydrogenase Aaci_0243 ENOG4105WMR Protein CrcB homolog Aaci_0249 ENOG4105EEX Two component transcriptional regulator (Winged helix family Aaci_0250 ENOG4105C08 Histidine kinase Aaci_0251 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) Aaci_0252 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) Aaci_0253 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) Aaci_0256 ENOG4105CPC Aldo Keto reductase Aaci_0257 ENOG4105EQ0 Major Facilitator superfamily Aaci_0258 ENOG4105VRS hydrolase family 18 Aaci_0259 ENOG4105DFW ABC transporter Aaci_0260 ENOG4105C2J ABC transporter Aaci_0261 ENOG4108HWW ABC transporter Aaci_0264 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) Aaci_0265 ENOG4108V06 Glutathione peroxidase Aaci_0268 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein Aaci_0272 ENOG4105D3Q Sugar transferase Aaci_0273 ENOG4108TJN glycosyl transferase group 1 Aaci_0275 ENOG4105MFV ABC-2 type transporter Aaci_0276 ENOG4105EY8 ABC transporter Aaci_0283 ENOG4105EYH Exonuclease Aaci_0285 ENOG4105C59 p-type ATPase Aaci_0286 ENOG4105CEY Amp-dependent synthetase and ligase Aaci_0288 ENOG4105K6V RNA polymerase Aaci_0290 ENOG4105CCD The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity) Aaci_0291 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) Aaci_0292 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) Aaci_0293 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) Aaci_0298 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) Aaci_0299 ENOG4105D6E homoserine dehydrogenase Aaci_0301 ENOG4107QHF type ii secretion system protein e Aaci_0302 ENOG4105D7Q type ii secretion system Aaci_0303 ENOG4108VAU general secretion pathway protein G Aaci_0310 ENOG4105CZX twitching motility protein Aaci_0312 ENOG4108I5C dEAD DEAH box helicase Aaci_0314 ENOG4108JUB Transcriptional regulator Aaci_0315 ENOG4108JPW Aminotransferase Aaci_0322 ENOG4105C8Y Acetylornithine aminotransferase Aaci_0323 ENOG4105C26 Dehydrogenase Aaci_0324 ENOG4108JUB Transcriptional regulator Aaci_0326 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) Aaci_0330 ENOG4105IEH endo-beta-N-acetylglucosaminidase Aaci_0331 ENOG4105CYX Short-chain dehydrogenase reductase Sdr Aaci_0332 ENOG4107QK4 glycoside hydrolase, family 3 domain protein Aaci_0335 ENOG4105D2S major facilitator superfamily Aaci_0338 ENOG4105C26 Dehydrogenase Aaci_0341 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) Aaci_0343 ENOG4105EYF MMPL domain protein Aaci_0345 ENOG41061WM D-Alanyl-D-Alanine Aaci_0346 ENOG4105BZ4 penicillin-binding protein Aaci_0351 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) Aaci_0354 ENOG41082V8 Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) Aaci_0355 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) Aaci_0356 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein Aaci_0357 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) Aaci_0359 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) Aaci_0360 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) Aaci_0362 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase Aaci_0365 ENOG4105ZKE UPF0349 protein Aaci_0368 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) Aaci_0369 ENOG4105K8N protein family UPF0079, ATPase Aaci_0371 ENOG410801F ribosomal-protein-alanine acetyltransferase Aaci_0372 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) Aaci_0373 ENOG4105C5H ABC transporter Aaci_0374 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase Aaci_0375 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase Aaci_0377 ENOG4105CEV competence damage-inducible protein Aaci_0378 ENOG4105FNP Molybdopterin-guanine dinucleotide biosynthesis protein b Aaci_0379 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) Aaci_0385 ENOG4105WH1 Two component transcriptional regulator luxr family Aaci_0387 ENOG4105C7R Atpase associated with various cellular activities aaa_3 Aaci_0390 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) Aaci_0392 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) Aaci_0393 ENOG4105C83 adenylosuccinate lyase Aaci_0394 ENOG4105C8V SAICAR synthetase Aaci_0397 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii Aaci_0399 ENOG4105CXB phosphoribosylaminoimidazole synthetase Aaci_0400 ENOG4105DC1 bifunctional purine biosynthesis protein purh Aaci_0401 ENOG4105C12 Phosphoribosylglycinamide synthetase Aaci_0403 ENOG4108J59 Extracellular solute-binding protein, family 5 Aaci_0404 ENOG4105DTQ mandelate racemase muconate lactonizing Aaci_0405 ENOG4105CAK Cell division ATP-binding protein ftsE Aaci_0406 ENOG4105CRP Part of the ABC transporter FtsEX involved in Aaci_0408 ENOG4105E14 MotA TolQ exbB proton channel Aaci_0409 ENOG4106VK6 Flagellar motor protein Aaci_0410 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) Aaci_0411 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) Aaci_0412 ENOG4105D1C Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) Aaci_0414 ENOG4106FI7 cytochrome c-type biogenesis protein Aaci_0416 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) Aaci_0417 ENOG4105CHW UPF0052 protein Aaci_0418 ENOG4105CIE May be required for sporulation (By similarity) Aaci_0419 ENOG4105KRI phosphocarrier protein (HPr Aaci_0424 ENOG4106I4J membrane Aaci_0425 ENOG4105C8T Leucyl-tRNA synthetase Aaci_0429 ENOG4105F4G Membrane Aaci_0432 ENOG4108I5C dEAD DEAH box helicase Aaci_0435 ENOG4105CGH 5'-nucleotidase Aaci_0436 ENOG4105CSM endonuclease III Aaci_0438 ENOG4105E1K spore germination protein Aaci_0442 ENOG4105C26 Dehydrogenase Aaci_0446 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) Aaci_0447 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) Aaci_0448 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) Aaci_0451 ENOG41069M3 Transcriptional regulator Aaci_0453 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) Aaci_0459 ENOG4105EBR Carboxylesterase Aaci_0460 ENOG4105CYN Serine protein kinase Aaci_0463 ENOG4107Y5K Resolvase Aaci_0471 ENOG4108IMY Transcriptional regulator Aaci_0484 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) Aaci_0498 ENOG4105UMD exodeoxyribonuclease X Aaci_0511 ENOG4105E2S oxidase) subunit II Aaci_0514 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) Aaci_0515 ENOG4105BZU Histidine kinase Aaci_0516 ENOG4105WH1 Two component transcriptional regulator luxr family Aaci_0520 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) Aaci_0522 ENOG4105C1Q protoporphyrinogen oxidase Aaci_0526 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase Aaci_0528 ENOG41081QV Universal stress protein Aaci_0535 ENOG4108YZ3 Glyoxalase Bleomycin resistance protein (Dioxygenase Aaci_0536 ENOG4107R5R arsenical pump membrane protein Aaci_0537 ENOG4108UXE Protein tyrosine phosphatase Aaci_0538 ENOG4107TCE N-acetyltransferase Aaci_0539 ENOG4105DFE Dna adenine methylase Aaci_0544 ENOG4105QIV RNA polymerase Aaci_0578 ENOG4107U53 septum site-determining protein minD Aaci_0601 ENOG4105XMH SpoVT AbrB domain protein Aaci_0602 ENOG4105M0J Toxic component of a toxin-antitoxin (TA) module. A Aaci_0618 ENOG4105KRN Transcriptional regulator, abrb family Aaci_0620 ENOG4107V2S Transcriptional regulator Aaci_0625 ENOG4105ED1 spovr family Aaci_0633 ENOG4105EN6 Membrane Aaci_0635 ENOG4105BZU Histidine kinase Aaci_0637 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) Aaci_0640 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase Aaci_0643 ENOG4105CJ1 ABC, transporter Aaci_0645 ENOG4105DVE abc transporter atp-binding protein Aaci_0646 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family Aaci_0647 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) Aaci_0648 ENOG4105DXB Major Facilitator superfamily Aaci_0652 ENOG4108M15 ABC transporter Aaci_0653 ENOG4105KCT ABC transporter Aaci_0654 ENOG4105BZU Histidine kinase Aaci_0658 ENOG4105E2S oxidase) subunit II Aaci_0660 ENOG4105CCU oxidase (Subunit III) Aaci_0661 ENOG41060D1 Quinol oxidase Aaci_0663 ENOG4105DZ1 carboxypeptidase Aaci_0667 ENOG4105CPC Aldo Keto reductase Aaci_0668 ENOG4108JB8 alcohol dehydrogenase Aaci_0669 ENOG4107EXU Short-chain dehydrogenase reductase Sdr Aaci_0673 ENOG4105BZU Histidine kinase Aaci_0678 ENOG41061TZ Short-chain dehydrogenase reductase Sdr Aaci_0679 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b Aaci_0682 ENOG4105C4R Atp-dependent dna helicase Aaci_0683 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) Aaci_0687 ENOG4105VB5 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) Aaci_0688 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) Aaci_0689 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) Aaci_0690 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) Aaci_0691 ENOG4105F6J Alpha beta hydrolase fold Aaci_0695 ENOG4105CJZ response regulator Aaci_0698 ENOG4105IDI abc transporter atp-binding protein Aaci_0704 ENOG4105DET Rhamnulokinase Aaci_0706 ENOG4105C9F isomerase Aaci_0708 ENOG4105C2J ABC transporter Aaci_0709 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane Aaci_0711 ENOG4105D4B ABC, transporter Aaci_0712 ENOG4105E98 transcriptional regulator DeoR family Aaci_0716 ENOG4107QR9 Iron-sulfur cluster binding protein Aaci_0717 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) Aaci_0719 ENOG4108QY0 Membrane Aaci_0720 ENOG41090VF Stage v sporulation protein ac Aaci_0721 ENOG4105CZ3 stage V sporulation protein ad Aaci_0723 ENOG4105EXC Acyl-transferase Aaci_0724 ENOG4105DG4 malate L-lactate dehydrogenase Aaci_0728 ENOG4105CEY Amp-dependent synthetase and ligase Aaci_0730 ENOG4105C54 Major Facilitator superfamily Aaci_0731 ENOG4105WG9 Conserved Protein Aaci_0732 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) Aaci_0735 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) Aaci_0738 ENOG4105DPN Oligoendopeptidase f Aaci_0739 ENOG4105BZU Histidine kinase Aaci_0740 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) Aaci_0741 ENOG4105BZA Phosphoglycerate kinase Aaci_0742 ENOG4105CP7 Triose-phosphate isomerase Aaci_0744 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) Aaci_0745 ENOG4105XZU Preprotein translocase, subunit SecG Aaci_0746 ENOG4105DJ2 Major Facilitator Superfamily Aaci_0747 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) Aaci_0748 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) Aaci_0749 ENOG4105C26 Dehydrogenase Aaci_0750 ENOG4105GPN Uncharacterized conserved protein (DUF2294) Aaci_0751 ENOG4108TWJ NADH dehydrogenase subunit 5 Aaci_0752 ENOG4105EVH UPF0753 protein Aaci_0754 ENOG4107XB0 Lipopolysaccharide 1,2-N-acetylglucosaminetransferase Aaci_0758 ENOG41089UC methyltransferase, type 11 Aaci_0761 ENOG4105DEN Luciferase family Aaci_0762 ENOG4107XWI flavin reductase domain protein, FMN-binding Aaci_0765 ENOG4105EIG urea carboxylase-associated protein 1 Aaci_0766 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase Aaci_0768 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component Aaci_0769 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component Aaci_0774 ENOG4107SCA Formamidase (EC 3.5.1.49) Aaci_0778 ENOG4105C3F Signal peptidase i Aaci_0779 ENOG4105CPC Aldo Keto reductase Aaci_0780 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) Aaci_0785 ENOG4105CMR udp-glucose 4-epimerase Aaci_0787 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) Aaci_0791 ENOG4105E2V Glycosyltransferase 36 Aaci_0792 ENOG4108KUU Inner membrane metabolite transport protein ydjE Aaci_0794 ENOG4105DRS transport system, permease Aaci_0796 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component Aaci_0799 ENOG4105DXD 2-methylcitrate dehydratase Aaci_0800 ENOG4105CR4 methylisocitrate lyase Aaci_0801 ENOG4105C7B Threonine dehydratase Aaci_0806 ENOG4108RZE Tetr family transcriptional regulator Aaci_0807 ENOG4105CRS phenylacetate-CoA oxygenase PaaG subunit Aaci_0810 ENOG4108ZA2 phenylacetate-CoA oxygenase PaaJ subunit Aaci_0811 ENOG4105DZS Phenylacetate-CoA ligase Aaci_0814 ENOG4105C26 Dehydrogenase Aaci_0815 ENOG4108UKI Enoyl-CoA hydratase Aaci_0816 ENOG4105CHU acetyl-coa acetyltransferase Aaci_0817 ENOG4107QSV RmuC domain protein Aaci_0819 ENOG41067MG lrgb family Aaci_0820 ENOG4105VAW lrga family Aaci_0821 ENOG4107RSM transcriptional regulator Aaci_0824 ENOG4105CIH Imidazole acetol-phosphate transaminase Aaci_0829 ENOG4105FR1 rard protein Aaci_0833 ENOG4105BZ1 (ABC) transporter Aaci_0834 ENOG4105BZ1 (ABC) transporter Aaci_0838 ENOG4105BZ1 (ABC) transporter Aaci_0841 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) Aaci_0842 ENOG4105TMB Formate nitrite transporter Aaci_0843 ENOG4108IEG Formate dehydrogenase Alpha subunit Aaci_0849 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) Aaci_0850 ENOG4105C6X Major Facilitator Aaci_0853 ENOG4108X4Q Hydrolase Aaci_0857 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) Aaci_0858 ENOG4105K63 Thioredoxin Aaci_0859 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) Aaci_0860 ENOG4105DKW ABC transporter Aaci_0861 ENOG4108YYC ycei family Aaci_0862 ENOG4105KVH Transcriptional regulator Aaci_0863 ENOG4105CE4 GlcNAc 6-P deacetylase Aaci_0864 ENOG4107RIQ Sulfate adenylate transferase Aaci_0865 ENOG4105K56 Transcriptional regulator Aaci_0867 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) Aaci_0868 ENOG4105C26 Dehydrogenase Aaci_0869 ENOG4105CPC Aldo Keto reductase Aaci_0870 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) Aaci_0874 ENOG4105C2C drug resistance transporter, Bcr CflA Aaci_0875 ENOG4105EEM helicase Aaci_0876 ENOG41075H3 AraC family transcriptional regulator Aaci_0877 ENOG41080V3 Major Facilitator superfamily Aaci_0878 ENOG41082BV acetyltransferase Aaci_0881 ENOG4108TN2 lmbE family Aaci_0882 ENOG4105KJF protein tyrosine phosphatase Aaci_0885 ENOG4105SZ6 Thioredoxin Aaci_0886 ENOG4105CD5 CoA-binding domain protein Aaci_0887 ENOG4105C3M thioredoxin reductase Aaci_0889 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN Aaci_0890 ENOG4105E98 transcriptional regulator DeoR family Aaci_0891 ENOG4105DE4 1-phosphofructokinase Aaci_0892 ENOG4105DM4 PTS System Aaci_0894 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) Aaci_0896 ENOG4108594 Permease of the drug metabolite transporter Aaci_0898 ENOG4105CZ9 Domain of unknown function (DU1801) Aaci_0900 ENOG4105C28 cystathionine Aaci_0904 ENOG4105CEY Amp-dependent synthetase and ligase Aaci_0905 ENOG4105DMF Dehydrogenase Aaci_0906 ENOG4108Z03 MAF-like protein Aaci_0908 ENOG4105CBX hi0933 family Aaci_0910 ENOG4107QW4 alcohol dehydrogenase Aaci_0911 ENOG4105ETE Transcriptional regulator (LacI family Aaci_0914 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component Aaci_0915 ENOG4105DRS transport system, permease Aaci_0916 ENOG4107QM5 aconitate hydratase Aaci_0917 ENOG4105ESV Glycosyl transferase, family 4 Aaci_0918 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) Aaci_0921 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) Aaci_0922 ENOG4108I7Y domain protein Aaci_0923 ENOG4108IQ6 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity) Aaci_0924 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) Aaci_0925 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) Aaci_0926 ENOG4105ECC imidazole-glycerol-phosphate dehydratase Aaci_0927 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) Aaci_0928 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase Aaci_0929 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) Aaci_0930 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase Aaci_0933 ENOG4105CIS alcohol dehydrogenase Aaci_0936 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) Aaci_0937 ENOG4108R6K riboflavin synthase, subunit alpha Aaci_0938 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) Aaci_0939 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) Aaci_0940 ENOG4105VEQ Cold shock protein Aaci_0944 ENOG4105NSK ABC superfamily ATP binding cassette transporter membrane protein Aaci_0945 ENOG4108JJB ABC transporter Aaci_0947 ENOG4105SKE transcriptional Regulator LysR family Aaci_0948 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) Aaci_0952 ENOG4105KHC sulfurtransferase Aaci_0954 ENOG4108TN2 lmbE family Aaci_0955 ENOG4105FDT acyl-CoA dehydrogenase Aaci_0957 ENOG4107XH4 PPIases accelerate the folding of proteins (By similarity) Aaci_0963 ENOG4108YBP pseudouridine synthase Aaci_0964 ENOG4107S2Z UPF0761 membrane protein Aaci_0965 ENOG4105KRF dihydroneopterin aldolase Aaci_0968 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) Aaci_0969 ENOG410890F Dynamin family Aaci_0970 ENOG4105C0H protease Aaci_0972 ENOG4108VD1 dedA family Aaci_0977 ENOG4105EUJ GTP cyclohydrolase i Aaci_0981 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) Aaci_0982 ENOG4105EMN RNA polymerase sigma factor Aaci_0984 ENOG4105DCF alanine dehydrogenase Aaci_0985 ENOG4105VG1 fes assembly suf system protein Aaci_0986 ENOG4105C3K feS assembly ATPase SufC Aaci_0987 ENOG4105JRK feS assembly protein SufD Aaci_0989 ENOG4108UNV SUF system FeS assembly protein, NifU family Aaci_0990 ENOG4105DIW FeS assembly protein SUFB Aaci_0995 ENOG4105ECY inositol monophosphatase Aaci_0996 ENOG4105DAP Nicotinate phosphoribosyltransferase Aaci_0997 ENOG4108IUH Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) Aaci_1000 ENOG4107QTZ amino acid Aaci_1004 ENOG4105VV2 Aaci_1005 ENOG4105C0D helicase Aaci_1009 ENOG4105C0B DNA polymerase III (alpha subunit) Aaci_1014 ENOG4107YU2 histidine triad (hIT) protein Aaci_1015 ENOG4105F0I Aminotransferase Aaci_1017 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) Aaci_1022 ENOG4108IYI Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) Aaci_1023 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) Aaci_1024 ENOG4105KA0 thioesterase Superfamily protein Aaci_1031 ENOG4105CNI cell division protein FtsW Aaci_1033 ENOG4108QXE glycerophosphoryl diester phosphodiesterase Aaci_1034 ENOG4105CNI cell division protein FtsW Aaci_1038 ENOG4108XFG YwhD family Aaci_1039 ENOG4105CXN decarboxylase Aaci_1040 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen Aaci_1041 ENOG4108YX9 iron--sulfur cluster insertion protein erpA Aaci_1042 ENOG4105DCI Phosphohydrolase Aaci_1043 ENOG4107ZTW SNARE associated Golgi Aaci_1044 ENOG4105KZD Domain of unknown function (DUF1805) Aaci_1045 ENOG4105CN9 Peptidase m42 family protein Aaci_1049 ENOG41069ER domain protein Aaci_1057 ENOG4105C26 Dehydrogenase Aaci_1058 ENOG41069DP small acid-soluble spore protein Aaci_1061 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) Aaci_1062 ENOG4105VTR Integrase Aaci_1087 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) Aaci_1097 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) Aaci_1099 ENOG4105UMD exodeoxyribonuclease X Aaci_1103 ENOG4105BZU Histidine kinase Aaci_1104 ENOG4105CK6 Two component transcriptional regulator (Winged helix family Aaci_1105 ENOG4107R16 Multicopper oxidase Aaci_1109 ENOG4107QIV Cytochrome c biogenesis protein Aaci_1111 ENOG4105E3B Multicopper oxidase Aaci_1112 ENOG4105VPX protein, conserved in bacteria Aaci_1113 ENOG4105C59 p-type ATPase Aaci_1114 ENOG4105C59 p-type ATPase Aaci_1117 ENOG4108ZC9 flagellar basal-body rod protein flgc Aaci_1118 ENOG4105Q75 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) Aaci_1120 ENOG4105HRU Glyoxalase Bleomycin resistance protein (Dioxygenase Aaci_1122 ENOG4105PGM cation diffusion facilitator family transporter Aaci_1123 ENOG4105KTU Transcriptional regulator, arsr family Aaci_1136 ENOG4105DFE Dna adenine methylase Aaci_1138 ENOG4105CKB glycosidase Aaci_1140 ENOG4105QIV RNA polymerase Aaci_1175 ENOG4105BZU Histidine kinase Aaci_1176 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase Aaci_1182 ENOG4107VUZ Aaci_1188 ENOG4105K70 DNA-binding protein Aaci_1194 ENOG4107QMS site-determining protein Aaci_1204 ENOG4105KRN Transcriptional regulator, abrb family Aaci_1209 ENOG4105C1G acyl-Coa dehydrogenase Aaci_1210 ENOG4108IPT Naphthoate synthase Aaci_1211 ENOG4105CHR reductase Aaci_1214 ENOG4105ETE Transcriptional regulator (LacI family Aaci_1217 ENOG4105DRS transport system, permease Aaci_1218 ENOG4105CNT hydrolase family 2 Aaci_1219 ENOG4105DDQ anthranilate synthase Aaci_1220 ENOG4105CRQ synthase (Component I) Aaci_1222 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase Aaci_1223 ENOG4105CAS nag kinase Aaci_1224 ENOG4105C8Y Acetylornithine aminotransferase Aaci_1227 ENOG4105DBV ornithine carbamoyltransferase Aaci_1228 ENOG4105CDH Citrulline--aspartate ligase Aaci_1229 ENOG4105CH7 arginosuccinase Aaci_1232 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) Aaci_1234 ENOG4105C0D helicase Aaci_1243 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family Aaci_1244 ENOG4105CZV ABC transporter Aaci_1246 ENOG4105WZW rhodanese family Aaci_1247 ENOG4105K63 Thioredoxin Aaci_1250 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase Aaci_1251 ENOG4105CS1 NAD(P)H quinone oxidoreductase Aaci_1252 ENOG4105DRR Transcriptional regulator, GntR family Aaci_1253 ENOG4106HK8 GPR1 FUN34 yaaH family protein Aaci_1254 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) Aaci_1255 ENOG41085AS UPF0473 protein Aaci_1260 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) Aaci_1261 ENOG4105C3J Cysteine desulfurase Aaci_1262 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) Aaci_1265 ENOG4108Q5U germination protein, ger(x)c family Aaci_1266 ENOG4108RKS Short-chain dehydrogenase reductase Sdr Aaci_1267 ENOG41074B2 UPF0747 protein Aaci_1268 ENOG4108V6E Cell division protein mraZ Aaci_1269 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) Aaci_1271 ENOG4105CJN penicillin-binding protein Aaci_1272 ENOG4105CJN penicillin-binding protein Aaci_1273 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) Aaci_1274 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) Aaci_1275 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) Aaci_1276 ENOG4105CNI cell division protein FtsW Aaci_1277 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) Aaci_1278 ENOG4107R4N Cell wall formation (By similarity) Aaci_1280 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase Aaci_1282 ENOG4107Y5K Resolvase Aaci_1286 ENOG4105K67 small basic protein Aaci_1287 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) Aaci_1288 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) Aaci_1289 ENOG4108AWX Sporulation factor SpoIIGA Aaci_1290 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) Aaci_1292 ENOG4105WR5 sporulation protein, YlmC YmxH family Aaci_1293 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase Aaci_1294 ENOG4105DFA alanine racemase domain protein Aaci_1300 ENOG4105SCY DNAK suppressor Aaci_1302 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) Aaci_1303 ENOG4105C34 Pseudouridine synthase Aaci_1304 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) Aaci_1305 ENOG4105CXT aspartate transcarbamylase Aaci_1306 ENOG4105CD3 dihydroorotase Aaci_1309 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) Aaci_1310 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) Aaci_1311 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) Aaci_1313 ENOG4105D82 Glutamate dehydrogenase Aaci_1314 ENOG4105F23 Fibronectin-binding protein Aaci_1316 ENOG4105DSJ YicC domain protein Aaci_1318 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase Aaci_1319 ENOG4105C25 Primosomal protein n' Aaci_1320 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) Aaci_1321 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) Aaci_1322 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B Aaci_1323 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs Aaci_1324 ENOG4108ZF3 Phosphatase Aaci_1325 ENOG4105D9P serine threonine protein kinase Aaci_1326 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) Aaci_1327 ENOG4105DJV ribulose-phosphate 3-epimerase Aaci_1329 ENOG4105VB9 50S ribosomal protein l28 Aaci_1330 ENOG4105CB5 ATP-dependent DNA helicase recG Aaci_1332 ENOG4105DJ4 phosphatidylserine decarboxylase Aaci_1335 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) Aaci_1336 ENOG4106H78 methyltransferase Aaci_1337 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) Aaci_1338 ENOG4105D78 K07001 NTE family protein Aaci_1340 ENOG41067VY 50S ribosomal protein L32 Aaci_1342 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) Aaci_1343 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase Aaci_1344 ENOG4105CHR reductase Aaci_1345 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) Aaci_1346 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) Aaci_1347 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) Aaci_1348 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) Aaci_1349 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) Aaci_1350 ENOG4105VBN Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein (By similarity) Aaci_1352 ENOG4105K5M 30s ribosomal protein S16 Aaci_1353 ENOG4105VB6 UPF0109 protein Aaci_1356 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) Aaci_1358 ENOG4105EI2 Pseudouridine synthase Aaci_1360 ENOG4105FAA peptidase M23 Aaci_1361 ENOG4108S4H thioesterase Superfamily protein Aaci_1366 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) Aaci_1367 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) Aaci_1368 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) Aaci_1370 ENOG4105D00 flagellar biosynthetic protein flhB Aaci_1371 ENOG4105VFF UPF0102 protein Aaci_1372 ENOG4108ZJ4 polysaccharide deacetylase Aaci_1373 ENOG4105C0P Mg chelatase subunit ChlI Aaci_1375 ENOG4105CMV Succinyl-CoA synthetase subunit beta Aaci_1376 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha Aaci_1381 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) Aaci_1382 ENOG4107QXI Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity) Aaci_1383 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) Aaci_1384 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) Aaci_1385 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) Aaci_1386 ENOG4105Q75 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) Aaci_1387 ENOG4108ZC9 flagellar basal-body rod protein flgc Aaci_1388 ENOG4105VQ0 flagellar hook-basal body complex protein fliE Aaci_1389 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) Aaci_1390 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) Aaci_1396 ENOG410822I Flagellar hook capping protein Aaci_1399 ENOG4105BZE flagellar hook protein, FlgE Aaci_1399 ENOG4105BZE flagellar hook protein, FlgE Aaci_1402 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) Aaci_1403 ENOG4105DD5 Flagellar motor switch protein Aaci_1404 ENOG4107YTP response regulator receiver protein Aaci_1406 ENOG4105CN7 Flagellar biosynthetic protein FliP Aaci_1407 ENOG4105VS8 Flagellar biosynthetic protein fliq Aaci_1409 ENOG4105D00 flagellar biosynthetic protein flhB Aaci_1410 ENOG4105D7B Flagellar biosynthesis protein flha Aaci_1411 ENOG4105FZW flagellar biosynthesis regulator FlhF Aaci_1414 ENOG4105CBS Chea signal transduction histidine kinase Aaci_1415 ENOG4108V3W Chemotaxis protein, CheW Aaci_1417 ENOG4108Z4W Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis (By similarity) Aaci_1419 ENOG4105CE9 30S ribosomal protein S2 Aaci_1420 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) Aaci_1421 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) Aaci_1422 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) Aaci_1423 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) Aaci_1424 ENOG4105KNE Phosphatidate cytidylyltransferase Aaci_1425 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) Aaci_1426 ENOG4105DZP Membrane-associated zinc metalloprotease Aaci_1427 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) Aaci_1430 ENOG4105CI3 gtp-binding protein typa Aaci_1431 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) Aaci_1432 ENOG4105CHV Transcription elongation factor NusA Aaci_1433 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination Aaci_1436 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) Aaci_1437 ENOG4105SFS phosphoesterase RecJ domain protein Aaci_1438 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) Aaci_1439 ENOG4105DTN riboflavin biosynthesis protein ribF Aaci_1441 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) Aaci_1442 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) Aaci_1443 ENOG4107VMI polysaccharide deacetylase Aaci_1444 ENOG4105C1V Peptidase, M16 Aaci_1446 ENOG4105E35 Dipicolinate synthase subunit A Aaci_1447 ENOG4108S0H Dipicolinic acid synthetase, b subunit Aaci_1448 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) Aaci_1450 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) Aaci_1452 ENOG4105C1G acyl-Coa dehydrogenase Aaci_1454 ENOG4105C26 Dehydrogenase Aaci_1455 ENOG4105E39 Enoyl-CoA hydratase Aaci_1456 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) Aaci_1457 ENOG4105CHU acetyl-coa acetyltransferase Aaci_1459 ENOG4107RDP Dehydrogenase Aaci_1460 ENOG4105CN5 Metallo-Beta-Lactamase Aaci_1461 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit Aaci_1463 ENOG4105CNU cell division protein FtsK Aaci_1469 ENOG4108VPT UPF0234 protein Aaci_1470 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase Aaci_1471 ENOG4105CEV competence damage-inducible protein Aaci_1472 ENOG4105C1J atp-dependent rna helicase Aaci_1473 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) Aaci_1475 ENOG4105E4Y Endoribonuclease that initiates mRNA decay (By similarity) Aaci_1476 ENOG4105MCT stage V sporulation protein S Aaci_1482 ENOG410839P Aaci_1484 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) Aaci_1486 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) Aaci_1487 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) Aaci_1488 ENOG4107YX5 Pfam:DUF548 Aaci_1489 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) Aaci_1490 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) Aaci_1500 ENOG4105UMD exodeoxyribonuclease X Aaci_1505 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) Aaci_1506 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) Aaci_1534 ENOG4108WQI RNA Polymerase Aaci_1558 ENOG4105E1K spore germination protein Aaci_1563 ENOG4105CMR udp-glucose 4-epimerase Aaci_1564 ENOG4105CKP Polysaccharide Biosynthesis Protein Aaci_1566 ENOG4106F1P AAA ATPase, central domain protein Aaci_1570 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) Aaci_1571 ENOG4105CXI aluminum resistance protein Aaci_1572 ENOG4105KV4 Transcriptional regulator Aaci_1573 ENOG4105C5F glutamine synthetase Aaci_1574 ENOG4105ETE Transcriptional regulator (LacI family Aaci_1575 ENOG4105CTX dehydratase Aaci_1576 ENOG4105DH8 myo-inositol catabolism Aaci_1577 ENOG4107QZW Altronate oxidoreductase Aaci_1579 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) Aaci_1580 ENOG4108HCJ Hydrolase Aaci_1581 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) Aaci_1585 ENOG4105BZU Histidine kinase Aaci_1590 ENOG4105C10 Electron transfer flavoprotein Aaci_1591 ENOG4105BZJ Electron transfer flavoprotein Aaci_1592 ENOG4107Z3H Transcriptional regulator, TetR family Aaci_1593 ENOG4105DF6 Fe-S oxidoreductase Aaci_1595 ENOG4105CHU acetyl-coa acetyltransferase Aaci_1596 ENOG4105C1G acyl-Coa dehydrogenase Aaci_1597 ENOG4105CEY Amp-dependent synthetase and ligase Aaci_1599 ENOG4107QYD Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) Aaci_1600 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) Aaci_1601 ENOG4105C0X amino acid Aaci_1602 ENOG4105EM2 membrane Aaci_1606 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) Aaci_1607 ENOG4105C2X Arabinose 5-phosphate isomerase Aaci_1608 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) Aaci_1609 ENOG4105CBT Fructose-1,6-bisphosphatase Aaci_1614 ENOG4108QBF Transcriptional regulator Aaci_1619 ENOG4105DF3 Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta-cleavage pathway for the degradation of aromatic compounds (By similarity) Aaci_1624 ENOG4105J4Q Transcriptional regulator Aaci_1627 ENOG4108S0S Nucleotidyl transferase Aaci_1628 ENOG4105C5F glutamine synthetase Aaci_1629 ENOG4108K16 Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) Aaci_1630 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) Aaci_1632 ENOG4108Z7R Chaperone CsaA Aaci_1635 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) Aaci_1636 ENOG4105CPF Cell wall formation (By similarity) Aaci_1638 ENOG4105C5S asparaginyl-tRNA synthetase Aaci_1639 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) Aaci_1642 ENOG4105YAC Aaci_1643 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) Aaci_1645 ENOG41080U2 Amidohydrolase family Aaci_1646 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) Aaci_1647 ENOG4105CB1 The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) Aaci_1648 ENOG4105DQE DNA ligase Aaci_1650 ENOG4105FDF Could be involved in DNA repair (By similarity) Aaci_1651 ENOG4105DVT helicase Aaci_1654 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate Aaci_1655 ENOG4105CPK Glycosyl transferase (Group 1 Aaci_1656 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) Aaci_1657 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase Aaci_1659 ENOG4105H20 Sporulation integral membrane protein YlbJ Aaci_1660 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) Aaci_1661 ENOG4108K88 Membrane Aaci_1662 ENOG4108JYZ YitT family Aaci_1665 ENOG4105EVN Prephenate dehydrogenase Aaci_1666 ENOG4108JPM phospho-2-dehydro-3-deoxyheptonate aldolase Aaci_1667 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) Aaci_1668 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) Aaci_1669 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase Aaci_1670 ENOG4105DK0 Indole-3-glycerol phosphate synthase Aaci_1671 ENOG4107S1N anthranilate phosphoribosyltransferase Aaci_1672 ENOG4105KHN chorismate mutase Aaci_1673 ENOG4105D49 3-dehydroquinate synthase Aaci_1674 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase Aaci_1675 ENOG4105CN9 Peptidase m42 family protein Aaci_1676 ENOG4105CN9 Peptidase m42 family protein Aaci_1677 ENOG4105CN9 Peptidase m42 family protein Aaci_1681 ENOG4105K4H Nlp p60 protein Aaci_1683 ENOG4105GMT ATPase associated with various cellular activities aaa_5 Aaci_1686 ENOG4108JQC penicillin-binding protein 1A Aaci_1689 ENOG4105BZU Histidine kinase Aaci_1691 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) Aaci_1692 ENOG4105EAH synthase Aaci_1693 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) Aaci_1695 ENOG4105WP2 Tryptophan RNA-binding attenuator protein Aaci_1696 ENOG4105DQ4 alcohol dehydrogenase Aaci_1697 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) Aaci_1698 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) Aaci_1699 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase Aaci_1700 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) Aaci_1701 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) Aaci_1703 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) Aaci_1705 ENOG4105CAT Cytidine monophosphate kinase Aaci_1707 ENOG4108T7K Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Increasing levels of c-di-GMP lead to decreased motility (By similarity) Aaci_1712 ENOG4108S6Z Negative regulator of genetic competence Aaci_1713 ENOG4105ETE Transcriptional regulator (LacI family Aaci_1715 ENOG4105ENA helicase Aaci_1715 ENOG4105ENA helicase Aaci_1717 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) Aaci_1719 ENOG4105C0H protease Aaci_1722 ENOG4108PNU Involved in the degradation of specific anti-sigma factors (By similarity) Aaci_1724 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) Aaci_1727 ENOG4105BZU Histidine kinase Aaci_1728 ENOG4105CK6 Two component transcriptional regulator (Winged helix family Aaci_1730 ENOG4105FE9 pseudouridine synthase Aaci_1732 ENOG4108JIC nucleoside recognition domain protein Aaci_1733 ENOG4105KBJ sporulation protein ytfj Aaci_1735 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) Aaci_1736 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) Aaci_1737 ENOG4108Z4T Peptidase M50 Aaci_1740 ENOG4105G6R Stage v sporulation protein ae Aaci_1742 ENOG4105CZ3 stage V sporulation protein ad Aaci_1743 ENOG41090VF Stage v sporulation protein ac Aaci_1744 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) Aaci_1748 ENOG4105DZ1 carboxypeptidase Aaci_1749 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) Aaci_1750 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) Aaci_1754 ENOG4108YZ4 nudix hydrolase Aaci_1756 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) Aaci_1757 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) Aaci_1758 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) Aaci_1759 ENOG4108ZAF Molybdopterin Aaci_1760 ENOG4105VRS hydrolase family 18 Aaci_1765 ENOG4107JTW chlorite dismutase Aaci_1768 ENOG4105S1Z Stage IV sporulation protein B Aaci_1769 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) Aaci_1770 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) Aaci_1772 ENOG4105DX0 Hemolysin A Aaci_1775 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) Aaci_1776 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) Aaci_1777 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) Aaci_1778 ENOG4105CAY ferredoxin--nadp reductase Aaci_1779 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) Aaci_1780 ENOG4105M7K Involved in the transcription termination process (By similarity) Aaci_1783 ENOG4108ZSR alkaline shock protein Aaci_1784 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase Aaci_1790 ENOG4105KQ4 Stage iii sporulation protein ad Aaci_1793 ENOG4105CD2 stage iii sporulation protein aa Aaci_1795 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) Aaci_1796 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) Aaci_1797 ENOG4107TB6 phosphoglycerate mutase Aaci_1798 ENOG4107RGW The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor Aaci_1799 ENOG4107QK8 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor Aaci_1800 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) Aaci_1801 ENOG4105C0D helicase Aaci_1803 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) Aaci_1804 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) Aaci_1809 ENOG4108VAU general secretion pathway protein G Aaci_1811 ENOG4107QHF type ii secretion system protein e Aaci_1813 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control Aaci_1815 ENOG4105K46 50S ribosomal protein l27 Aaci_1816 ENOG41087JC Protein of unknown function (DUF464) Aaci_1820 ENOG4107QMS site-determining protein Aaci_1821 ENOG4107YDG Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) Aaci_1824 ENOG4105DFF Rod shape-determining protein mreb Aaci_1825 ENOG4105W5Q DNA repair protein (RadC Aaci_1827 ENOG4105HSS phospholipase C Aaci_1828 ENOG41069ER domain protein Aaci_1829 ENOG4105DFU Cell wall formation (By similarity) Aaci_1830 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase Aaci_1831 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) Aaci_1835 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase Aaci_1836 ENOG4105D52 delta-aminolevulinic acid dehydratase Aaci_1838 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) Aaci_1840 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) Aaci_1841 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) Aaci_1843 ENOG4108IUQ atp-dependent protease Aaci_1844 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) Aaci_1845 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) Aaci_1846 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation Aaci_1847 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) Aaci_1848 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) Aaci_1849 ENOG41067TZ transcriptional regulator, MarR family Aaci_1850 ENOG4105C1G acyl-Coa dehydrogenase Aaci_1854 ENOG4105PFC Transcriptional regulator Aaci_1855 ENOG4105C87 Aminotransferase class I and II Aaci_1857 ENOG4105FDP GntR family transcriptional regulator Aaci_1858 ENOG4105C0R drug resistance transporter emrb qaca subfamily Aaci_1859 ENOG4105C72 UPF0176 protein Aaci_1861 ENOG4105E33 succinate dehydrogenase Aaci_1863 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit Aaci_1864 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) Aaci_1866 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) Aaci_1868 ENOG4105CIH Imidazole acetol-phosphate transaminase Aaci_1870 ENOG4105UPD Calcium Proton Aaci_1876 ENOG4105CKK Glycosyl transferase, family 2 Aaci_1878 ENOG41067TZ transcriptional regulator, MarR family Aaci_1881 ENOG4105E66 phosphoriboisomerase A Aaci_1882 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) Aaci_1885 ENOG4105PGM cation diffusion facilitator family transporter Aaci_1887 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) Aaci_1888 ENOG4105D4U had-superfamily hydrolase, subfamily iia Aaci_1889 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) Aaci_1891 ENOG410838F Glycosyl transferase family 2 Aaci_1892 ENOG41060GT Translocates 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane (By similarity) Aaci_1893 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) Aaci_1895 ENOG4105CS2 ec 3.2.1.21 Aaci_1896 ENOG4108JQ7 (ABC) transporter Aaci_1902 ENOG4108Z4U Ferredoxin Aaci_1905 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) Aaci_1909 ENOG4105MXW flavin reductase domain protein, FMN-binding Aaci_1913 ENOG4108QBV Monogalactosyldiacylglycerol synthase Aaci_1917 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) Aaci_1918 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) Aaci_1919 ENOG4105E4F Isochorismate synthase Aaci_1920 ENOG4105CEY Amp-dependent synthetase and ligase Aaci_1921 ENOG4108IPT Naphthoate synthase Aaci_1922 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase Aaci_1923 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) Aaci_1925 ENOG4108IEG Formate dehydrogenase Alpha subunit Aaci_1926 ENOG4105C7Z Conserved Protein Aaci_1927 ENOG4105C7Z Conserved Protein Aaci_1928 ENOG4108W0I acetyltransferase Aaci_1929 ENOG4108UZ3 Transporter Aaci_1931 ENOG4105ETU transcriptional activator (TenA Aaci_1932 ENOG4105DWF phosphomethylpyrimidine kinase Aaci_1933 ENOG4105C4U 4-methyl-5-beta-hydroxyethylthiazole kinase Aaci_1934 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) Aaci_1935 ENOG4108JJ8 (ABC) transporter Aaci_1936 ENOG4108JJ9 ABC, transporter Aaci_1937 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii Aaci_1938 ENOG4105C4M (Ubiquinol oxidase) subunit I Aaci_1939 ENOG4105C0R drug resistance transporter emrb qaca subfamily Aaci_1940 ENOG41067TZ transcriptional regulator, MarR family Aaci_1942 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) Aaci_1943 ENOG4105EHG Permease protein Aaci_1944 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) Aaci_1949 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase Aaci_1950 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) Aaci_1953 ENOG4107R33 ppx gppa phosphatase Aaci_1959 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) Aaci_1966 ENOG4105BZU Histidine kinase Aaci_1968 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase Aaci_1969 ENOG4105BZU Histidine kinase Aaci_1974 ENOG4105EGD dinuclear metal center protein, YbgI family Aaci_1977 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) Aaci_1978 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) Aaci_1979 ENOG4108SAY Involved in DNA repair and RecF pathway recombination (By similarity) Aaci_1981 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) Aaci_1983 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) Aaci_1984 ENOG4105CTJ Metal Dependent Phosphohydrolase Aaci_1985 ENOG4105C9A Phoh family Aaci_1988 ENOG4105KTH gatB Yqey Aaci_1989 ENOG4105VCC 30S ribosomal protein S21 Aaci_1992 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) Aaci_1993 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) Aaci_1994 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) Aaci_1995 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) Aaci_1996 ENOG4105CFG Acts as a chaperone (By similarity) Aaci_1997 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ Aaci_1998 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) Aaci_1999 ENOG4105CSA Coproporphyrinogen iii oxidase Aaci_2000 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) Aaci_2003 ENOG4105E4C Lytic transglycosylase catalytic Aaci_2005 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) Aaci_2010 ENOG4105KQC Competence protein Aaci_2011 ENOG4105KST dependent repressor Aaci_2012 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) Aaci_2014 ENOG4108WF2 Metal Dependent Phosphohydrolase Aaci_2015 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) Aaci_2016 ENOG4105E2X shikimate dehydrogenase Aaci_2017 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) Aaci_2020 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) Aaci_2021 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) Aaci_2024 ENOG4108Z08 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) Aaci_2025 ENOG4105VBH UPF0297 protein Aaci_2026 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) Aaci_2027 ENOG4105C02 permease Aaci_2028 ENOG41060CR Aaci_2029 ENOG4107QI6 Cysteine desulfurase Aaci_2033 ENOG4108UXE Protein tyrosine phosphatase Aaci_2035 ENOG4105CEY Amp-dependent synthetase and ligase Aaci_2037 ENOG4105C9M aspartyl-trna synthetase Aaci_2038 ENOG4105CUT histidyl-tRNA synthetase Aaci_2040 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase Aaci_2043 ENOG4105CJ1 ABC, transporter Aaci_2045 ENOG4105D94 Major Facilitator Superfamily Aaci_2048 ENOG4105DRS transport system, permease Aaci_2051 ENOG4105E39 Enoyl-CoA hydratase Aaci_2052 ENOG4107QX3 carboxylase Aaci_2053 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase Aaci_2054 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit Aaci_2056 ENOG4105C1G acyl-Coa dehydrogenase Aaci_2058 ENOG4105CHU acetyl-coa acetyltransferase Aaci_2059 ENOG4108IIH CoA-transferase subunit B Aaci_2060 ENOG4105D6N CoA-transferase, subunit a Aaci_2063 ENOG4105CSD Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) Aaci_2064 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B Aaci_2065 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase Aaci_2071 ENOG4105CPC Aldo Keto reductase Aaci_2072 ENOG4105CVM Molybdenum cofactor synthesis domain protein Aaci_2073 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase Aaci_2074 ENOG41068JE domain protein Aaci_2076 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation Aaci_2077 ENOG4105C5N The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination Aaci_2078 ENOG41079KZ Major Facilitator Superfamily Aaci_2080 ENOG4105CUB amino acid Aaci_2081 ENOG4108JPW Aminotransferase Aaci_2082 ENOG4108JUB Transcriptional regulator Aaci_2083 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) Aaci_2085 ENOG4105DZ1 carboxypeptidase Aaci_2088 ENOG4108Y6J UPF0403 protein Aaci_2089 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) Aaci_2090 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) Aaci_2091 ENOG4105C1Q protoporphyrinogen oxidase Aaci_2094 ENOG4105BZU Histidine kinase Aaci_2097 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) Aaci_2098 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) Aaci_2099 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) Aaci_2100 ENOG41076HS cation diffusion facilitator family transporter Aaci_2101 ENOG4107SBW Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) Aaci_2102 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) Aaci_2104 ENOG4105CKP Polysaccharide Biosynthesis Protein Aaci_2109 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) Aaci_2110 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) Aaci_2111 ENOG4105WJF Aaci_2112 ENOG4108WZW RNA polymerase sigma Aaci_2113 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) Aaci_2114 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) Aaci_2115 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) Aaci_2117 ENOG4105CDY transcriptional regulatory protein Aaci_2118 ENOG4105C4K Nad synthetase Aaci_2119 ENOG4105C4K Nad synthetase Aaci_2123 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) Aaci_2124 ENOG4105BZ4 penicillin-binding protein Aaci_2125 ENOG4105C98 muts2 protein Aaci_2128 ENOG410687F Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity) Aaci_2129 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) Aaci_2130 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) Aaci_2132 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit Aaci_2133 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) Aaci_2134 ENOG4105EIE fructose-bisphosphate aldolase Aaci_2135 ENOG4105CTQ phosphohexokinase Aaci_2136 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) Aaci_2137 ENOG4105C8Q Methyl-accepting chemotaxis Aaci_2138 ENOG4105KRI phosphocarrier protein (HPr Aaci_2142 ENOG4105DWT malate dehydrogenase (quinone) Aaci_2143 ENOG4105C7S Dehydrogenase Aaci_2144 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 Aaci_2146 ENOG4105C7R Atpase associated with various cellular activities aaa_3 Aaci_2149 ENOG4105DG6 mannose-6-phosphate isomerase Aaci_2150 ENOG4105C5I Dehydrogenase Aaci_2154 ENOG4105CK5 oxidoreductase Aaci_2155 ENOG4107QP6 Xylose isomerase domain protein TIM barrel Aaci_2160 ENOG4105FE8 tRNA (Guanosine-2'-O-)-methyltransferase Aaci_2163 ENOG4107T66 Releases the N-terminal proline from various substrates (By similarity) Aaci_2164 ENOG4105CUB amino acid Aaci_2165 ENOG4105WEF catalase Aaci_2169 ENOG4108RWN rrna methyltransferase Aaci_2170 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) Aaci_2171 ENOG4105VJV 50s ribosomal protein L35 Aaci_2173 ENOG41066VF YeeE YedE family protein Aaci_2175 ENOG4105C22 threonyL-tRNA synthetase Aaci_2179 ENOG4105CMG Carbohydrate kinase Aaci_2180 ENOG4105C93 Xylose Isomerase Aaci_2181 ENOG4105D2S major facilitator superfamily Aaci_2190 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) Aaci_2200 ENOG4108FN7 Aldo keto reductase Aaci_2201 ENOG4107R5R arsenical pump membrane protein Aaci_2205 ENOG4107QM2 Aldo Keto reductase Aaci_2206 ENOG4107TYA transient receptor potential locus Aaci_2208 ENOG4105KZX Pterin carbinolamine dehydratase Aaci_2211 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) Aaci_2215 ENOG4107RBB ABC transporter, permease Aaci_2216 ENOG4105C19 ABC transporter Aaci_2219 ENOG41080XP Cbs domain Aaci_2221 ENOG4105BZN citrate synthase Aaci_2222 ENOG4108UI1 Probably functions as a manganese efflux pump (By similarity) Aaci_2223 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase Aaci_2224 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) Aaci_2225 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) Aaci_2226 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) Aaci_2227 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase Aaci_2228 ENOG4108ZP8 Acetolactate synthase small subunit Aaci_2229 ENOG4105C7K acetolactate synthase Aaci_2230 ENOG4105C01 Dihydroxy-acid dehydratase Aaci_2232 ENOG4105CM2 brancheD-chain amino acid aminotransferase Aaci_2233 ENOG4105D6E homoserine dehydrogenase Aaci_2237 ENOG4107T3P ABC, transporter Aaci_2238 ENOG4105ETE Transcriptional regulator (LacI family Aaci_2242 ENOG4105D3R alkyl hydroperoxide reductase Aaci_2245 ENOG4105VRS hydrolase family 18 Aaci_2247 ENOG4108IQI permease Aaci_2254 ENOG4105BZ1 (ABC) transporter Aaci_2255 ENOG4105BZ1 (ABC) transporter Aaci_2258 ENOG4105HJK ABC transporter Aaci_2260 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component Aaci_2261 ENOG4105DEF Extracellular solute-binding protein, family 5 Aaci_2262 ENOG4108JQ7 (ABC) transporter Aaci_2263 ENOG4105C3U ABC transporter Aaci_2264 ENOG4105ETX regulatoR Aaci_2266 ENOG4108KMH lipoate-protein ligase a Aaci_2267 ENOG4105GR3 Histidine kinase Aaci_2268 ENOG4105CK6 Two component transcriptional regulator (Winged helix family Aaci_2269 ENOG4105DND Transcriptional regulator Aaci_2271 ENOG4105CGK Exodeoxyribonuclease III Aaci_2275 ENOG4105CS9 pantothenic acid kinase Aaci_2276 ENOG4108RVA ribokinase Aaci_2277 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator Aaci_2278 ENOG4105CNN ABC, transporter Aaci_2279 ENOG4105C2J ABC transporter Aaci_2280 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) Aaci_2281 ENOG4105ETE Transcriptional regulator (LacI family Aaci_2282 ENOG4105BZ1 (ABC) transporter Aaci_2283 ENOG4105BZ1 (ABC) transporter Aaci_2284 ENOG4107XVH Transcriptional regulator Aaci_2286 ENOG4105E0X reductase Aaci_2288 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase Aaci_2289 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) Aaci_2290 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) Aaci_2292 ENOG4105BZW Glycerate kinase Aaci_2305 ENOG41069D7 Methyl-accepting chemotaxis Aaci_2306 ENOG4108JP0 extracellular solute-binding protein family 1 Aaci_2316 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) Aaci_2319 ENOG4105C6X Major Facilitator Aaci_2324 ENOG4105F0Z galactose-1-phosphate uridylyltransferase Aaci_2325 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) Aaci_2330 ENOG4105CPQ Dehydrogenase Aaci_2332 ENOG4107RF6 penicillin-binding protein Aaci_2342 ENOG4106S48 Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and or cell division Aaci_2343 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) Aaci_2344 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) Aaci_2346 ENOG4105CQC Prephenate dehydratase Aaci_2348 ENOG4108HMX isocitrate dehydrogenase (NADP) Aaci_2350 ENOG4105XJC Two component transcriptional regulator (Winged helix family Aaci_2351 ENOG4105C31 Tryptophanyl-tRNA synthetase Aaci_2352 ENOG4105CA9 Pyruvate kinase Aaci_2353 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) Aaci_2354 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) Aaci_2356 ENOG4105C0B DNA polymerase III (alpha subunit) Aaci_2358 ENOG4107AYK membrAne Aaci_2362 ENOG4105C6T cysteine synthase Aaci_2363 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) Aaci_2364 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) Aaci_2368 ENOG4105E8R UPF0173 metal-dependent hydrolase Aaci_2369 ENOG41084CE UPF0342 protein Aaci_2370 ENOG4108Z18 K06886 hemoglobin Aaci_2372 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) Aaci_2374 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) Aaci_2375 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) Aaci_2376 ENOG4105D7W serine acetyltransferase Aaci_2377 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) Aaci_2379 ENOG4105KGF protein, YerC YecD Aaci_2381 ENOG4107R16 Multicopper oxidase Aaci_2390 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) Aaci_2391 ENOG41089WN small, acid-soluble spore protein tlp Aaci_2394 ENOG4105CPQ Dehydrogenase Aaci_2395 ENOG4105C1G acyl-Coa dehydrogenase Aaci_2396 ENOG4105CEY Amp-dependent synthetase and ligase Aaci_2397 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) Aaci_2398 ENOG4105CAN Short-chain dehydrogenase reductase Sdr Aaci_2399 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase Aaci_2400 ENOG4105CEY Amp-dependent synthetase and ligase Aaci_2401 ENOG4105C1G acyl-Coa dehydrogenase Aaci_2402 ENOG4108JPM phospho-2-dehydro-3-deoxyheptonate aldolase Aaci_2404 ENOG4107Y2H ErfK ybiS ycfS ynhG family protein Aaci_2412 ENOG4105CAN Short-chain dehydrogenase reductase Sdr Aaci_2413 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) Aaci_2415 ENOG4105CPC Aldo Keto reductase Aaci_2417 ENOG4105C8Q Methyl-accepting chemotaxis Aaci_2419 ENOG4105CIY formyltetrahydrofolate deformylase Aaci_2422 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) Aaci_2423 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) Aaci_2424 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) Aaci_2427 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) Aaci_2428 ENOG4105C0R drug resistance transporter emrb qaca subfamily Aaci_2429 ENOG4105CW7 secretion protein, HlyD family Aaci_2430 ENOG4107RF6 penicillin-binding protein Aaci_2431 ENOG4105CND Glycosyl transferase, family 2 Aaci_2433 ENOG41061P3 phosphosulfolactate synthase Aaci_2435 ENOG4105GEU Spore germination protein Aaci_2437 ENOG4108Q5U germination protein, ger(x)c family Aaci_2438 ENOG4105E1K spore germination protein Aaci_2439 ENOG4105C0H protease Aaci_2443 ENOG4105EWU Squalene--hopene cyclase Aaci_2446 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) Aaci_2447 ENOG4106UJV Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) Aaci_2448 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) Aaci_2455 ENOG4105E3B Multicopper oxidase Aaci_2456 ENOG4107STQ Multicopper oxidase Aaci_2458 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component Aaci_2459 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component Aaci_2462 ENOG4105DDC Oxidoreductase domain protein Aaci_2463 ENOG4105ETE Transcriptional regulator (LacI family Aaci_2468 ENOG4105BZU Histidine kinase Aaci_2469 ENOG4107YBY Hydrolase Aaci_2471 ENOG4105C3U ABC transporter Aaci_2472 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component Aaci_2473 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component Aaci_2474 ENOG4108J59 Extracellular solute-binding protein, family 5 Aaci_2475 ENOG4105E08 Glycoside hydrolase, family 9 Aaci_2476 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) Aaci_2477 ENOG4108IYU L-aspartate oxidase Aaci_2478 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase Aaci_2480 ENOG4105D06 uba thif-type nad fad binding protein Aaci_2481 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) Aaci_2483 ENOG41080HI glycine oxidase Aaci_2484 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) Aaci_2485 ENOG4105E2M Manganese-dependent inorganic pyrophosphatase Aaci_2491 ENOG4107QSI ABC, transporter Aaci_2494 ENOG4105ECP epimerase Aaci_2495 ENOG4105DJB Major Facilitator Superfamily Aaci_2501 ENOG4108Z0Z intracellular protease Pfpi family Aaci_2502 ENOG4105FKZ Methyl-accepting chemotaxis Aaci_2503 ENOG4107QTZ amino acid Aaci_2504 ENOG4105C26 Dehydrogenase Aaci_2509 ENOG4107TVC Glycosyl transferase, family 2 Aaci_2511 ENOG4105DUM transcriptional regulator, lysR family Aaci_2517 ENOG4105CPQ Dehydrogenase Aaci_2519 ENOG4105D3R alkyl hydroperoxide reductase Aaci_2520 ENOG4105G5W regulator Fur family Aaci_2521 ENOG4107WD4 Releases the N-terminal proline from various substrates (By similarity) Aaci_2523 ENOG4105C85 amino acid Aaci_2525 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family Aaci_2526 ENOG4105CQB FAD linked oxidase domain protein Aaci_2527 ENOG4108I5G Major Facilitator superfamily Aaci_2528 ENOG4105E5G Alpha beta hydrolase fold Aaci_2529 ENOG4105DAA L-lactate Aaci_2530 ENOG4107QP3 malate synthase g Aaci_2531 ENOG4107HP6 Transcriptional regulator Aaci_2532 ENOG4105CQB FAD linked oxidase domain protein Aaci_2533 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) Aaci_2534 ENOG4105CQB FAD linked oxidase domain protein Aaci_2535 ENOG4105CND Glycosyl transferase, family 2 Aaci_2538 ENOG41082YX Transcriptional regulator, arsr family Aaci_2546 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) Aaci_2550 ENOG4107XCH Cyclase family Aaci_2551 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase Aaci_2553 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving Aaci_2554 ENOG4105MS2 ribosomal subunit Interface protein Aaci_2557 ENOG4107QRS glycosyltransferase group 2 family protein Aaci_2558 ENOG4107QVI Methyltransferase, type 11 Aaci_2559 ENOG4107TVC Glycosyl transferase, family 2 Aaci_2560 ENOG4105DTS flagellar hook-associated Aaci_2561 ENOG4105I03 Flagellin Aaci_2562 ENOG4105DTJ flagellar hook-associated protein Aaci_2568 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) Aaci_2569 ENOG4105BZU Histidine kinase Aaci_2570 ENOG4105DPZ Two component transcriptional regulator (Winged helix family Aaci_2573 ENOG4105WH1 Two component transcriptional regulator luxr family Aaci_2574 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP Aaci_2577 ENOG4105C6X Major Facilitator Aaci_2579 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) Aaci_2580 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) Aaci_2581 ENOG4105II7 pyrroline-5-carboxylate reductase Aaci_2582 ENOG4107XM9 (LipO)protein Aaci_2585 ENOG4105JAB phenazine biosynthesis protein, phzf family Aaci_2595 ENOG4105CPC Aldo Keto reductase Aaci_2596 ENOG4107QIV Cytochrome c biogenesis protein Aaci_2597 ENOG4107QX9 Thiol disulfide interChange protein Aaci_2601 ENOG41081YB ApbE family Aaci_2605 ENOG4105C0R drug resistance transporter emrb qaca subfamily Aaci_2606 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) Aaci_2607 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) Aaci_2610 ENOG4107RCC Major Facilitator Superfamily Aaci_2612 ENOG4105N80 Ferric uptake regulator, Fur family Aaci_2613 ENOG4105DSE periplasmic solute binding protein Aaci_2614 ENOG4105DIK (ABC) transporter Aaci_2617 ENOG4108S4H thioesterase Superfamily protein Aaci_2620 ENOG4105BZU Histidine kinase Aaci_2621 ENOG4105D9R oxidoreductase Aaci_2622 ENOG4107RGD Major Facilitator superfamily Aaci_2624 ENOG4108T5E Copper resistance protein Aaci_2625 ENOG4105KTB nuclear export factor GLE1 Aaci_2626 ENOG4105CJ3 phosphate transporter Aaci_2630 ENOG4107QK4 glycoside hydrolase, family 3 domain protein Aaci_2631 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase Aaci_2634 ENOG4105DU6 RNA polymerase Aaci_2639 ENOG4105VPX protein, conserved in bacteria Aaci_2641 ENOG4107TPS domain protein Aaci_2642 ENOG4105VFE sira family Aaci_2643 ENOG4108ZCA Inherit from COG: pyridine nucleotide-disulfide oxidoreductase Aaci_2644 ENOG41085GJ domain protein Aaci_2645 ENOG41087NI Sulfite exporter TauE/SafE Aaci_2650 ENOG4105KCF CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease (By similarity) Aaci_2651 ENOG4105DYN CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity) Aaci_2653 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) Aaci_2656 ENOG4105DFE Dna adenine methylase Aaci_2658 ENOG4105VPX protein, conserved in bacteria Aaci_2659 ENOG4108ZSR alkaline shock protein Aaci_2662 ENOG4108ZAA Alkaline-shock protein Aaci_2663 ENOG4108ZB6 transcriptional regulator AsnC family Aaci_2664 ENOG4105CHM Aminotransferase Aaci_2666 ENOG4105DQ4 alcohol dehydrogenase Aaci_2667 ENOG4105ST3 Transcriptional regulator Aaci_2668 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) Aaci_2669 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) Aaci_2670 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) Aaci_2671 ENOG4107U5W ybbr family Aaci_2672 ENOG4105C8B TIGR00159 family Aaci_2674 ENOG4108NMV polysaccharide deacetylase Aaci_2676 ENOG4105D1F ATP-binding protein Aaci_2679 ENOG4108UJD 30S ribosomal protein S9 Aaci_2680 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) Aaci_2681 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) Aaci_2682 ENOG4108ZT0 50S ribosomal protein l17 Aaci_2683 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) Aaci_2684 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) Aaci_2685 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) Aaci_2686 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits Aaci_2687 ENOG41067V7 50S ribosomal protein L36 Aaci_2688 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) Aaci_2690 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) Aaci_2691 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) Aaci_2692 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) Aaci_2693 ENOG4105VPB 50S ribosomal protein L30 Aaci_2694 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) Aaci_2695 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) Aaci_2696 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) Aaci_2697 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) Aaci_2698 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) Aaci_2699 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits Aaci_2700 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) Aaci_2701 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) Aaci_2702 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal Aaci_2703 ENOG41082SA 50s ribosomal protein l29 Aaci_2704 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) Aaci_2705 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) Aaci_2707 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) Aaci_2708 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity Aaci_2709 ENOG41080UE One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) Aaci_2710 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) Aaci_2711 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) Aaci_2712 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) Aaci_2713 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) Aaci_2714 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) Aaci_2715 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) Aaci_2716 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) Aaci_2717 ENOG4105XPM ribosomal protein Aaci_2718 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) Aaci_2719 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) Aaci_2720 ENOG4107Y49 methyltransferase Aaci_2721 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) Aaci_2722 ENOG4108VZM 50s ribosomal protein L10 Aaci_2723 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) Aaci_2724 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) Aaci_2725 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) Aaci_2727 ENOG4105WDJ 50S ribosomal protein L33 Aaci_2728 ENOG4105QIV RNA polymerase Aaci_2730 ENOG4105C2N RNA methyltransferase TrmH family group 3 Aaci_2731 ENOG4105KEB Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc) Aaci_2732 ENOG4105C8N cysteinyl-tRNA synthetase Aaci_2734 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) Aaci_2735 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) Aaci_2736 ENOG4105CTP PilT protein domain protein Aaci_2737 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase Aaci_2738 ENOG4105E59 Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity) Aaci_2739 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) Aaci_2740 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit Aaci_2741 ENOG41066A3 ATP guanido phosphotransferase Aaci_2742 ENOG4108Z0C Uvrb UvrC protein Aaci_2745 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) Aaci_2746 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase Aaci_2747 ENOG4108JQA flagellar Aaci_2750 ENOG4105MT0 Sporulation transcriptional regulator spoiiid Aaci_2751 ENOG4105FRN stage II sporulation protein Aaci_2753 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) Aaci_2756 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) Aaci_2757 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) Aaci_2758 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) Aaci_2759 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) Aaci_2760 ENOG4105E3N F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) Aaci_2761 ENOG4107ZFM Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity) Aaci_2763 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) Aaci_2766 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase Aaci_2767 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) Aaci_2768 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) Aaci_2770 ENOG4107WAU Protein tyrosine phosphatase Aaci_2773 ENOG4105XPP Protein of unknown function (DUF1275) Aaci_2777 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) Aaci_2778 ENOG4108ZXQ stage ii sporulation protein r Aaci_2779 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) Aaci_2780 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) Aaci_2781 ENOG41082DI 50s ribosomal protein l31 Aaci_2782 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) Aaci_2783 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) Aaci_2785 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) Aaci_2786 ENOG4108Z1Y Participates in both the initiation and recycling phases of transcription. In the presence of the delta subunit, RNAP displays an increased specificity of transcription, a decreased affinity for nucleic acids, and an increased efficiency of RNA synthesis because of enhanced recycling (By similarity) Aaci_2787 ENOG4105E39 Enoyl-CoA hydratase Aaci_2788 ENOG4105E7W lamb ycsf family protein Aaci_2790 ENOG4105P4J Allophanate hydrolase, subunit 1 Aaci_2793 ENOG4105CYW agmatinase Aaci_2794 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) Aaci_2795 ENOG4105C1G acyl-Coa dehydrogenase Aaci_2797 ENOG4105BZ4 penicillin-binding protein Aaci_2804 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) Aaci_2805 ENOG4108Z5K methylglyoxal synthase Aaci_2806 ENOG4107RAQ aminopeptidase Aaci_2812 ENOG4105CMG Carbohydrate kinase Aaci_2815 ENOG4105D63 family UPF0324 Aaci_2816 ENOG4107RQD Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid (By similarity) Aaci_2817 ENOG4105EUJ GTP cyclohydrolase i Aaci_2819 ENOG4105FE1 phytoene synthase Aaci_2821 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) Aaci_2823 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) Aaci_2824 ENOG4105CND Glycosyl transferase, family 2 Aaci_2827 ENOG4108V7B Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide (By similarity) Aaci_2828 ENOG4106DF1 Aaci_2830 ENOG4108M60 Transcriptional regulator Aaci_2832 ENOG4105D3A purine nucleoside phosphorylase DeoD-type Aaci_2833 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) Aaci_2834 ENOG4105CH2 amidohydrolase Aaci_2836 ENOG4105CHM Aminotransferase Aaci_2840 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) Aaci_2841 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) Aaci_2842 ENOG4105ECW sulfate abc transporter Aaci_2843 ENOG4108I5D sulfate abc transporter Aaci_2844 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein Aaci_2845 ENOG4105E2Y ABC, transporter Aaci_2846 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component Aaci_2848 ENOG4105GVF (ABC) transporter Aaci_2851 ENOG4108Z6Z Transcriptional regulator Aaci_2852 ENOG4105C1G acyl-Coa dehydrogenase Aaci_2854 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) Aaci_2856 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) Aaci_2857 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) Aaci_2859 ENOG4105C4B ABC transporter, permease Aaci_2860 ENOG4108IXI (ABC) transporter Aaci_2861 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein Aaci_2865 ENOG41084M5 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) Aaci_2867 ENOG4105BZU Histidine kinase Aaci_2870 ENOG4105FKQ transcriptional regulator Aaci_2871 ENOG4105EG2 ABC transporter, permease Aaci_2873 ENOG4107FKK extracellular solute-binding protein family 1 Aaci_2876 ENOG4105EUB pirin domain protein Aaci_2877 ENOG41081VB Hydrolase Aaci_2879 ENOG41079KZ Major Facilitator Superfamily Aaci_2884 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) Aaci_2885 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) Aaci_2887 ENOG4105CJQ hydrolase, family 31 Aaci_2888 ENOG41081QV Universal stress protein Aaci_2889 ENOG4108J59 Extracellular solute-binding protein, family 5 Aaci_2890 ENOG4107XVH Transcriptional regulator Aaci_2891 ENOG4105C4C beta-galactosidase Aaci_2893 ENOG4108YZA Nitrogen regulatory protein pii Aaci_2897 ENOG4105CAC Catalyzes the conversion of L-arabinose to L-ribulose (By similarity) Aaci_2899 ENOG4105EF1 ribulokinase Aaci_2901 ENOG4105CMD Transcriptional regulator, GntR family Aaci_2903 ENOG4105CNN ABC, transporter Aaci_2904 ENOG4105C2J ABC transporter Aaci_2905 ENOG4105CMD Transcriptional regulator, GntR family Aaci_2909 ENOG4105C0R drug resistance transporter emrb qaca subfamily Aaci_2910 ENOG4105CW7 secretion protein, HlyD family Aaci_2911 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) Aaci_2912 ENOG4108VHC Short-chain dehydrogenase reductase Sdr Aaci_2915 ENOG4105DUM transcriptional regulator, lysR family Aaci_2917 ENOG4105C0H protease Aaci_2918 ENOG4105Q2H domain protein Aaci_2921 ENOG4105BZU Histidine kinase Aaci_2922 ENOG4105CK6 Two component transcriptional regulator (Winged helix family Aaci_2924 ENOG4105CDU Replicative dna helicase Aaci_2925 ENOG4105K9Q Binds to the 23S rRNA (By similarity) Aaci_2928 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) Aaci_2929 ENOG4108UUM single-stranded DNA-binding protein Aaci_2930 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) Aaci_2931 ENOG4105C3G gtp-binding protein Aaci_2933 ENOG4108J2R molybdopterin oxidoreductase Aaci_2934 ENOG4105VDK protein, conserved in bacteria Aaci_2935 ENOG4105D8X mechanosensitive ion channel Aaci_2937 ENOG4108ZDA Sporulation protein YyaC Aaci_2939 ENOG4108UQV Membrane Aaci_2940 ENOG4105FA0 parb-like partition protein Aaci_2941 ENOG4107QJE Chromosome Partitioning Protein Aaci_2943 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) Aaci_2944 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) Aaci_2945 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) Aaci_2946 ENOG4108Z7S Single-stranded nucleic acid binding R3H domain-containing protein Aaci_2947 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins Aaci_2948 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) Aaci_2950 ENOG4105VG0 50S ribosomal protein l34 Aaci_2967 ENOG4105E4C Lytic transglycosylase catalytic Aaci_2968 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase Aaci_2979 ENOG4107QJE Chromosome Partitioning Protein Aaci_2989 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) Aaci_2994 ENOG4107TCE N-acetyltransferase Aaci_3004 ENOG4105W5Q DNA repair protein (RadC Aaci_3005 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) Aaci_3009 ENOG4107WZZ SMC domain protein Aaci_3011 ENOG4108UUM single-stranded DNA-binding protein Aaci_3020 ENOG4105CFI type iii restriction protein res subunit Aaci_3023 ENOG4105C4R Atp-dependent dna helicase Aaci_3025 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) Aaci_3056 ENOG4105E5H Transposase Aaci_3063 ENOG4108JCI Transcriptional regulator Aaci_3065 ENOG4108UMN azlc family Aaci_3070 ENOG4105E1K spore germination protein Aaci_3076 ENOG4105BZU Histidine kinase Aaci_3086 ENOG4107QMH DNA methylase Aaci_3088 ENOG4105QIV RNA polymerase Aaci_3092 ENOG4105WH1 Two component transcriptional regulator luxr family Aaci_3118 ENOG4105D1F ATP-binding protein