locus-tag	class	description
Aaci_0002	COG0592	DNA-directed DNA polymerase activity
Aaci_0003	COG2501	S4 domain
Aaci_0004	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
Aaci_0005	COG0187	DNA topoisomerase II activity
Aaci_0006	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
Aaci_0011	COG0516	GMP reductase activity
Aaci_0011	COG0517	IMP dehydrogenase activity
Aaci_0012	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
Aaci_0013	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
Aaci_0018	COG1525	nuclease
Aaci_0023	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
Aaci_0027	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
Aaci_0028	COG2224	Isocitrate lyase
Aaci_0033	COG1744	ABC transporter substrate-binding protein PnrA-like
Aaci_0034	COG1335	isochorismatase
Aaci_0036	COG0824	Thioesterase
Aaci_0039	COG3842	ATPase activity
Aaci_0044	COG0745	RESPONSE REGULATOR receiver
Aaci_0045	COG5002	protein histidine kinase activity
Aaci_0047	COG1279	arginine transmembrane transporter activity
Aaci_0050	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
Aaci_0052	COG0789	Transcriptional regulator
Aaci_0054	COG1392	Phosphate transport regulator
Aaci_0055	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
Aaci_0056	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
Aaci_0058	COG1802	Transcriptional regulator
Aaci_0059	COG1028	Short-chain dehydrogenase reductase Sdr
Aaci_0064	COG4191	Histidine kinase
Aaci_0065	COG1215	transferase activity, transferring glycosyl groups
Aaci_0066	COG0194	GDP metabolic process
Aaci_0070	COG1435	thymidine kinase activity
Aaci_0072	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
Aaci_0072	COG0644	oxidoreductase
Aaci_0073	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
Aaci_0074	COG0584	glycerophosphoryl diester phosphodiesterase
Aaci_0076	COG0395	ABC-type sugar transport system, permease component
Aaci_0077	COG1175	transmembrane transport
Aaci_0078	COG2309	aminopeptidase activity
Aaci_0080	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
Aaci_0081	COG1309	transcriptional regulator
Aaci_0082	COG1511	domain protein
Aaci_0083	COG3973	AAA domain
Aaci_0084	COG0588	phosphoglycerate mutase activity
Aaci_0085	COG0166	Belongs to the GPI family
Aaci_0086	COG1940	carbohydrate kinase activity
Aaci_0094	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
Aaci_0096	COG1850	ribulose-bisphosphate carboxylase activity
Aaci_0097	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
Aaci_0098	COG0235	Class ii aldolase
Aaci_0101	COG0367	asparagine synthase
Aaci_0103	COG0590	tRNA wobble adenosine to inosine editing
Aaci_0104	COG3852	Histidine kinase
Aaci_0106	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
Aaci_0107	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
Aaci_0108	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
Aaci_0109	COG1970	mechanosensitive ion channel activity
Aaci_0110	COG1802	Transcriptional regulator
Aaci_0117	COG2244	polysaccharide biosynthetic process
Aaci_0120	COG1982	Orn Lys Arg decarboxylase major
Aaci_0121	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
Aaci_0122	COG3870	Protein conserved in bacteria
Aaci_0123	COG0470	DNA polymerase III
Aaci_0124	COG1774	PSP1 C-terminal conserved region
Aaci_0125	COG4467	Involved in initiation control of chromosome replication
Aaci_0127	COG2002	toxin-antitoxin pair type II binding
Aaci_0129	COG0084	hydrolase, TatD family'
Aaci_0132	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
Aaci_0133	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
Aaci_0139	COG2197	response regulator
Aaci_0142	COG0318	PFAM AMP-dependent synthetase and ligase
Aaci_0144	COG1960	acyl-CoA dehydrogenase activity
Aaci_0145	COG1024	Enoyl-CoA hydratase
Aaci_0146	COG1028	Short-chain dehydrogenase reductase Sdr
Aaci_0150	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
Aaci_0152	COG1012	belongs to the aldehyde dehydrogenase family
Aaci_0153	COG1454	alcohol dehydrogenase
Aaci_0155	COG1960	acyl-CoA dehydrogenase activity
Aaci_0157	COG1028	Short-chain dehydrogenase reductase Sdr
Aaci_0158	COG1960	acyl-CoA dehydrogenase activity
Aaci_0159	COG0318	PFAM AMP-dependent synthetase and ligase
Aaci_0160	COG2030	dehydratase
Aaci_0165	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
Aaci_0169	COG2801	Transposase and inactivated derivatives
Aaci_0170	COG4466	Protein conserved in bacteria
Aaci_0174	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
Aaci_0175	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
Aaci_0176	COG0251	oxidation-reduction process
Aaci_0177	COG2088	sporulation resulting in formation of a cellular spore
Aaci_0178	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
Aaci_0179	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
Aaci_0180	COG0193	aminoacyl-tRNA hydrolase activity
Aaci_0182	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
Aaci_0183	COG2002	toxin-antitoxin pair type II binding
Aaci_0185	COG3956	TIGRFAM MazG family protein
Aaci_0187	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
Aaci_0191	COG1098	S1 RNA binding domain
Aaci_0194	COG2131	deaminase
Aaci_0195	COG2208	phosphoserine phosphatase activity
Aaci_0196	COG2304	oxidoreductase activity
Aaci_0198	COG0037	tRNA processing
Aaci_0200	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Aaci_0204	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
Aaci_0205	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
Aaci_0206	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
Aaci_0207	COG1396	sequence-specific DNA binding
Aaci_0211	COG2318	DinB family
Aaci_0212	COG1968	undecaprenyl-diphosphatase activity
Aaci_0213	COG2223	nitrite transmembrane transporter activity
Aaci_0214	COG0697	spore germination
Aaci_0216	COG1028	Short-chain dehydrogenase reductase Sdr
Aaci_0217	COG0436	Aminotransferase
Aaci_0218	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
Aaci_0221	COG3711	transcriptional antiterminator
Aaci_0223	COG0246	Mannitol dehydrogenase
Aaci_0224	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
Aaci_0225	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
Aaci_0226	COG1595	DNA-templated transcription, initiation
Aaci_0231	COG3845	ABC transporter
Aaci_0233	COG1268	BioY protein
Aaci_0237	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
Aaci_0240	COG1028	Short-chain dehydrogenase reductase Sdr
Aaci_0243	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
Aaci_0246	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
Aaci_0249	COG0745	RESPONSE REGULATOR receiver
Aaci_0250	COG2205	protein histidine kinase activity
Aaci_0251	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
Aaci_0252	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
Aaci_0253	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
Aaci_0254	COG2205	protein histidine kinase activity
Aaci_0256	COG0667	Aldo Keto reductase
Aaci_0257	COG2814	Major facilitator Superfamily
Aaci_0258	COG1388	LysM domain
Aaci_0258	COG3858	chitin binding
Aaci_0259	COG4213	ABC transporter substrate-binding protein
Aaci_0261	COG4214	carbohydrate transport
Aaci_0264	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Aaci_0265	COG0386	Belongs to the glutathione peroxidase family
Aaci_0268	COG1739	Uncharacterized protein family UPF0029
Aaci_0272	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
Aaci_0282	COG0420	3'-5' exonuclease activity
Aaci_0283	COG0419	ATPase involved in DNA repair
Aaci_0285	COG2217	Heavy metal translocating P-type atpase
Aaci_0286	COG0318	PFAM AMP-dependent synthetase and ligase
Aaci_0288	COG1595	DNA-templated transcription, initiation
Aaci_0290	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
Aaci_0291	COG0805	protein transport
Aaci_0293	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
Aaci_0298	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
Aaci_0301	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
Aaci_0302	COG1459	type II secretion system
Aaci_0312	COG1111	helicase
Aaci_0312	COG1205	dead DEAH box helicase
Aaci_0314	COG3829	transcription factor binding
Aaci_0315	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
Aaci_0322	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
Aaci_0323	COG1012	belongs to the aldehyde dehydrogenase family
Aaci_0324	COG3829	transcription factor binding
Aaci_0325	COG0833	amino acid
Aaci_0330	COG4193	domain, Protein
Aaci_0330	COG5263	repeat protein
Aaci_0331	COG1028	Short-chain dehydrogenase reductase Sdr
Aaci_0335	COG2814	Major facilitator Superfamily
Aaci_0338	COG1012	belongs to the aldehyde dehydrogenase family
Aaci_0341	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
Aaci_0342	COG0753	catalase activity
Aaci_0343	COG2409	Drug exporters of the RND superfamily
Aaci_0343	COG1033	growth of symbiont in host cell
Aaci_0344	COG4846	Membrane protein involved in cytochrome C biogenesis
Aaci_0346	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
Aaci_0350	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
Aaci_0351	COG0024	Methionine aminopeptidase
Aaci_0354	COG0736	holo-[acyl-carrier-protein] synthase activity
Aaci_0355	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
Aaci_0355	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
Aaci_0356	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
Aaci_0357	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
Aaci_0359	COG2337	Toxic component of a toxin-antitoxin (TA) module
Aaci_0360	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
Aaci_0361	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
Aaci_0362	COG3437	response regulator, receiver
Aaci_0362	COG2770	Histidine kinase
Aaci_0365	COG4844	belongs to the
Aaci_0368	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
Aaci_0369	COG0802	atpase or kinase
Aaci_0371	COG0456	acetyltransferase
Aaci_0372	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
Aaci_0373	COG0488	(ABC) transporter
Aaci_0374	COG0671	phosphoesterase, PA-phosphatase related
Aaci_0375	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
Aaci_0377	COG1058	Belongs to the CinA family
Aaci_0377	COG1546	Belongs to the CinA family
Aaci_0378	COG1763	Mo-molybdopterin cofactor biosynthetic process
Aaci_0379	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
Aaci_0385	COG2197	response regulator
Aaci_0387	COG0714	Associated with various cellular activities
Aaci_0389	COG1305	Transglutaminase-like
Aaci_0390	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Aaci_0392	COG0519	Catalyzes the synthesis of GMP from XMP
Aaci_0392	COG0518	GMP synthase (glutamine-hydrolyzing) activity
Aaci_0393	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
Aaci_0394	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
Aaci_0395	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
Aaci_0397	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
Aaci_0398	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
Aaci_0399	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
Aaci_0400	COG0138	bifunctional purine biosynthesis protein purh
Aaci_0401	COG0151	Belongs to the GarS family
Aaci_0403	COG4166	transmembrane transport
Aaci_0404	COG4948	Mandelate Racemase Muconate Lactonizing
Aaci_0405	COG2884	Cell division ATP-binding protein ftsE
Aaci_0406	COG2177	Part of the ABC transporter FtsEX involved in
Aaci_0407	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Aaci_0408	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
Aaci_0410	COG0556	nucleotide-excision repair
Aaci_0411	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
Aaci_0412	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
Aaci_0414	COG4235	cytochrome complex assembly
Aaci_0416	COG1660	Displays ATPase and GTPase activities
Aaci_0417	COG0391	Required for morphogenesis under gluconeogenic growth conditions
Aaci_0418	COG1481	regulation of sporulation
Aaci_0419	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
Aaci_0424	COG0670	Belongs to the BI1 family
Aaci_0425	COG0495	leucyl-tRNA aminoacylation
Aaci_0429	COG0628	permease
Aaci_0432	COG1205	dead DEAH box helicase
Aaci_0432	COG1111	helicase
Aaci_0435	COG0737	Belongs to the 5'-nucleotidase family
Aaci_0436	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
Aaci_0438	COG0697	spore germination
Aaci_0442	COG1012	belongs to the aldehyde dehydrogenase family
Aaci_0445	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Aaci_0446	COG0328	RNA-DNA hybrid ribonuclease activity
Aaci_0447	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
Aaci_0448	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
Aaci_0450	COG0538	isocitrate dehydrogenase activity
Aaci_0451	COG1414	Transcriptional regulator
Aaci_0453	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
Aaci_0459	COG2272	Belongs to the type-B carboxylesterase lipase family
Aaci_0460	COG2766	serine protein kinase
Aaci_0461	COG2718	Belongs to the UPF0229 family
Aaci_0463	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
Aaci_0465	COG1396	sequence-specific DNA binding
Aaci_0471	COG1396	sequence-specific DNA binding
Aaci_0484	COG0592	DNA-directed DNA polymerase activity
Aaci_0498	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
Aaci_0499	COG2801	Transposase and inactivated derivatives
Aaci_0508	COG3328	transposase activity
Aaci_0511	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
Aaci_0515	COG5002	protein histidine kinase activity
Aaci_0516	COG2197	response regulator
Aaci_0526	COG3437	response regulator, receiver
Aaci_0526	COG0784	Response regulator, receiver
Aaci_0528	COG0589	response to stress
Aaci_0535	COG0346	lactoylglutathione lyase activity
Aaci_0536	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
Aaci_0537	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
Aaci_0538	COG1247	-acetyltransferase
Aaci_0539	COG0338	D12 class N6 adenine-specific DNA methyltransferase
Aaci_0578	COG2894	cell division
Aaci_0601	COG4456	Virulence-associated protein
Aaci_0618	COG2002	toxin-antitoxin pair type II binding
Aaci_0620	COG0583	DNA-binding transcription factor activity
Aaci_0625	COG2719	SpoVR family
Aaci_0633	COG2860	membrane
Aaci_0635	COG2200	EAL domain
Aaci_0635	COG2199	diguanylate cyclase activity
Aaci_0637	COG0529	Catalyzes the synthesis of activated sulfate
Aaci_0640	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
Aaci_0641	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
Aaci_0643	COG1131	(ABC) transporter
Aaci_0645	COG1131	(ABC) transporter
Aaci_0646	COG1725	Transcriptional regulator
Aaci_0647	COG1234	tRNA 3'-trailer cleavage
Aaci_0648	COG2814	Major facilitator Superfamily
Aaci_0649	COG1846	Transcriptional regulator
Aaci_0652	COG1131	(ABC) transporter
Aaci_0653	COG0842	Transport permease protein
Aaci_0654	COG4585	Histidine kinase
Aaci_0655	COG2197	response regulator
Aaci_0658	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
Aaci_0660	COG1845	cytochrome c oxidase, subunit III
Aaci_0661	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
Aaci_0662	COG1612	heme a metabolic process
Aaci_0663	COG1686	Belongs to the peptidase S11 family
Aaci_0667	COG0667	Aldo Keto reductase
Aaci_0668	COG1454	alcohol dehydrogenase
Aaci_0669	COG1028	Short-chain dehydrogenase reductase Sdr
Aaci_0678	COG1028	Short-chain dehydrogenase reductase Sdr
Aaci_0679	COG3384	dioxygenase
Aaci_0680	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
Aaci_0682	COG0210	DNA helicase
Aaci_0683	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
Aaci_0687	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Aaci_0688	COG0154	amidase activity
Aaci_0689	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Aaci_0690	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
Aaci_0691	COG1073	alpha beta
Aaci_0698	COG0842	Transport permease protein
Aaci_0698	COG1131	(ABC) transporter
Aaci_0698	COG1716	ATPase activity
Aaci_0704	COG1070	Carbohydrate kinase
Aaci_0705	COG1028	Short-chain dehydrogenase reductase Sdr
Aaci_0705	COG3347	Dehydrogenase
Aaci_0706	COG4952	isomerase
Aaci_0708	COG1129	ABC transporter
Aaci_0709	COG1172	Belongs to the binding-protein-dependent transport system permease family
Aaci_0712	COG1349	DNA-binding transcription factor activity
Aaci_0716	COG1139	Iron-sulfur cluster binding protein
Aaci_0717	COG0247	lactate metabolic process
Aaci_0719	COG2323	membrane
Aaci_0721	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
Aaci_0723	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
Aaci_0723	COG2755	lipolytic protein G-D-S-L family
Aaci_0724	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
Aaci_0728	COG0318	PFAM AMP-dependent synthetase and ligase
Aaci_0730	COG2271	Major facilitator Superfamily
Aaci_0731	COG2155	Conserved Protein
Aaci_0732	COG0019	diaminopimelate decarboxylase activity
Aaci_0735	COG1914	H( )-stimulated, divalent metal cation uptake system
Aaci_0738	COG1164	Oligoendopeptidase f
Aaci_0739	COG5002	protein histidine kinase activity
Aaci_0740	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
Aaci_0741	COG0126	phosphoglycerate kinase activity
Aaci_0742	COG0149	triose-phosphate isomerase activity
Aaci_0744	COG0148	phosphopyruvate hydratase activity
Aaci_0745	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
Aaci_0746	COG2807	transmembrane transport
Aaci_0747	COG0557	exoribonuclease II activity
Aaci_0748	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
Aaci_0749	COG1012	belongs to the aldehyde dehydrogenase family
Aaci_0750	COG5609	conserved protein (DUF2294)
Aaci_0751	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
Aaci_0752	COG3002	Belongs to the UPF0753 family
Aaci_0758	COG2226	methyltransferase
Aaci_0761	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
Aaci_0762	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
Aaci_0765	COG3665	Urea carboxylase-associated protein
Aaci_0766	COG0439	Biotin carboxylase
Aaci_0768	COG0395	ABC-type sugar transport system, permease component
Aaci_0769	COG1175	transmembrane transport
Aaci_0778	COG0681	Belongs to the peptidase S26 family
Aaci_0779	COG0667	Aldo Keto reductase
Aaci_0780	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
Aaci_0785	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
Aaci_0787	COG0673	inositol 2-dehydrogenase activity
Aaci_0791	COG3459	Glycosyltransferase 36 associated
Aaci_0792	COG2814	Major facilitator Superfamily
Aaci_0794	COG0395	ABC-type sugar transport system, permease component
Aaci_0796	COG1175	transmembrane transport
Aaci_0797	COG1486	melibiose metabolic process
Aaci_0799	COG2079	MmgE PrpD family protein
Aaci_0800	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
Aaci_0801	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
Aaci_0804	COG0542	response to heat
Aaci_0806	COG1309	transcriptional regulator
Aaci_0807	COG3396	Phenylacetate-CoA oxygenase
Aaci_0810	COG2151	metal-sulfur cluster biosynthetic enzyme
Aaci_0811	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
Aaci_0814	COG1012	belongs to the aldehyde dehydrogenase family
Aaci_0815	COG1024	Enoyl-CoA hydratase
Aaci_0817	COG1322	Protein conserved in bacteria
Aaci_0819	COG1346	cytolysis
Aaci_0820	COG1380	Effector of murein hydrolase LrgA
Aaci_0821	COG0583	DNA-binding transcription factor activity
Aaci_0823	COG2808	Putative FMN-binding domain
Aaci_0824	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
Aaci_0829	COG2962	Rard protein
Aaci_0833	COG1132	(ABC) transporter
Aaci_0834	COG1132	(ABC) transporter
Aaci_0835	COG0604	alcohol dehydrogenase
Aaci_0838	COG1132	(ABC) transporter
Aaci_0841	COG5609	conserved protein (DUF2294)
Aaci_0842	COG2116	formate transmembrane transporter activity
Aaci_0843	COG3383	formate dehydrogenase (NAD+) activity
Aaci_0845	COG1252	NADH dehydrogenase
Aaci_0848	COG0656	L-ascorbic acid biosynthetic process
Aaci_0849	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Aaci_0850	COG2814	Major facilitator Superfamily
Aaci_0853	COG0561	phosphatase activity
Aaci_0857	COG0519	Catalyzes the synthesis of GMP from XMP
Aaci_0859	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
Aaci_0860	COG1119	ATPase activity
Aaci_0861	COG2353	YceI-like domain
Aaci_0862	COG1733	regulation of RNA biosynthetic process
Aaci_0864	COG2046	Belongs to the sulfate adenylyltransferase family
Aaci_0865	COG1846	Transcriptional regulator
Aaci_0867	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Aaci_0868	COG1012	belongs to the aldehyde dehydrogenase family
Aaci_0869	COG0667	Aldo Keto reductase
Aaci_0870	COG0220	tRNA (guanine-N7-)-methyltransferase activity
Aaci_0871	COG1335	isochorismatase
Aaci_0874	COG2814	Major facilitator Superfamily
Aaci_0875	COG3973	AAA domain
Aaci_0876	COG2207	Transcriptional regulator
Aaci_0877	COG0477	Major facilitator Superfamily
Aaci_0878	COG2153	protein acetylation
Aaci_0880	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
Aaci_0882	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
Aaci_0885	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Aaci_0889	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
Aaci_0890	COG1349	DNA-binding transcription factor activity
Aaci_0891	COG1105	Belongs to the carbohydrate kinase PfkB family
Aaci_0894	COG0154	amidase activity
Aaci_0895	COG2363	Small membrane protein
Aaci_0898	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
Aaci_0900	COG0626	cystathionine gamma-synthase activity
Aaci_0904	COG0318	PFAM AMP-dependent synthetase and ligase
Aaci_0906	COG0424	maF-like protein
Aaci_0908	COG2081	HI0933 family
Aaci_0910	COG1979	alcohol dehydrogenase
Aaci_0914	COG1175	transmembrane transport
Aaci_0915	COG0395	ABC-type sugar transport system, permease component
Aaci_0916	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
Aaci_0917	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
Aaci_0921	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
Aaci_0922	COG1652	LysM domain
Aaci_0922	COG2823	Periplasmic or secreted lipoprotein
Aaci_0923	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
Aaci_0924	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
Aaci_0925	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
Aaci_0926	COG0131	Imidazoleglycerol-phosphate dehydratase
Aaci_0927	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
Aaci_0928	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
Aaci_0929	COG0107	imidazoleglycerol-phosphate synthase activity
Aaci_0930	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
Aaci_0930	COG0140	phosphoribosyl-ATP diphosphatase activity
Aaci_0933	COG0604	alcohol dehydrogenase
Aaci_0936	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
Aaci_0936	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
Aaci_0938	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
Aaci_0938	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
Aaci_0939	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
Aaci_0940	COG1278	Cold shock
Aaci_0944	COG4721	ABC-type cobalt transport system, permease component
Aaci_0945	COG1122	ATPase activity
Aaci_0947	COG0583	DNA-binding transcription factor activity
Aaci_0948	COG0482	sulfurtransferase activity
Aaci_0955	COG1960	acyl-CoA dehydrogenase activity
Aaci_0957	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
Aaci_0963	COG0564	pseudouridine synthase activity
Aaci_0964	COG1295	ribonuclease BN
Aaci_0965	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
Aaci_0968	COG1160	GTP binding
Aaci_0969	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
Aaci_0970	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Aaci_0972	COG0586	Pfam SNARE associated Golgi protein
Aaci_0977	COG0302	gtp cyclohydrolase
Aaci_0981	COG0167	dihydroorotate dehydrogenase activity
Aaci_0984	COG0686	Belongs to the AlaDH PNT family
Aaci_0985	COG2151	metal-sulfur cluster biosynthetic enzyme
Aaci_0986	COG0396	ATPase activity
Aaci_0987	COG0719	Fe-S assembly protein
Aaci_0988	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
Aaci_0989	COG0822	iron-sulfur transferase activity
Aaci_0990	COG0719	Fe-S assembly protein
Aaci_0992	COG1959	2 iron, 2 sulfur cluster binding
Aaci_0996	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
Aaci_0997	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
Aaci_1000	COG0531	amino acid
Aaci_1005	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
Aaci_1009	COG0587	DNA-directed DNA polymerase activity
Aaci_1011	COG0671	phosphoesterase, PA-phosphatase related
Aaci_1014	COG0537	adenosine 5'-monophosphoramidase activity
Aaci_1015	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
Aaci_1017	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
Aaci_1019	COG0612	Peptidase, M16
Aaci_1020	COG0612	Peptidase, M16
Aaci_1022	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
Aaci_1023	COG0083	homoserine kinase activity
Aaci_1024	COG2050	protein possibly involved in aromatic compounds catabolism
Aaci_1031	COG0772	Belongs to the SEDS family
Aaci_1033	COG0584	glycerophosphoryl diester phosphodiesterase
Aaci_1034	COG0772	Belongs to the SEDS family
Aaci_1035	COG0436	Aminotransferase
Aaci_1039	COG1982	Orn Lys Arg decarboxylase major
Aaci_1040	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
Aaci_1041	COG0316	Belongs to the HesB IscA family
Aaci_1042	COG1078	dGTPase activity
Aaci_1043	COG0586	Pfam SNARE associated Golgi protein
Aaci_1044	COG3377	Domain of unknown function (DUF1805)
Aaci_1045	COG1363	Peptidase, m42
Aaci_1046	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
Aaci_1047	COG0494	nUDIX hydrolase
Aaci_1049	COG3584	3D domain protein
Aaci_1049	COG1388	LysM domain
Aaci_1057	COG1012	belongs to the aldehyde dehydrogenase family
Aaci_1061	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
Aaci_1062	COG0582	viral genome integration into host DNA
Aaci_1064	COG1396	sequence-specific DNA binding
Aaci_1087	COG0592	DNA-directed DNA polymerase activity
Aaci_1097	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
Aaci_1099	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
Aaci_1102	COG0038	chloride channel
Aaci_1103	COG5002	protein histidine kinase activity
Aaci_1104	COG0745	RESPONSE REGULATOR receiver
Aaci_1105	COG2132	Multicopper oxidase
Aaci_1109	COG0785	Cytochrome C biogenesis protein
Aaci_1111	COG2132	Multicopper oxidase
Aaci_1112	COG1937	Protein conserved in bacteria
Aaci_1113	COG2217	Heavy metal translocating P-type atpase
Aaci_1114	COG2217	Heavy metal translocating P-type atpase
Aaci_1120	COG0346	lactoylglutathione lyase activity
Aaci_1123	COG0640	Transcriptional regulator
Aaci_1136	COG0338	D12 class N6 adenine-specific DNA methyltransferase
Aaci_1138	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
Aaci_1176	COG3437	response regulator, receiver
Aaci_1182	COG2020	methyltransferase activity
Aaci_1188	COG0776	regulation of translation
Aaci_1194	COG2894	cell division
Aaci_1204	COG2002	toxin-antitoxin pair type II binding
Aaci_1209	COG1960	acyl-CoA dehydrogenase activity
Aaci_1210	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
Aaci_1211	COG1028	Short-chain dehydrogenase reductase Sdr
Aaci_1214	COG1609	Transcriptional regulator
Aaci_1217	COG0395	ABC-type sugar transport system, permease component
Aaci_1218	COG3250	beta-galactosidase activity
Aaci_1219	COG0512	Glutamine amidotransferase of anthranilate synthase
Aaci_1222	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
Aaci_1223	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
Aaci_1224	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
Aaci_1226	COG0070	glutamate synthase
Aaci_1226	COG0067	glutamate synthase
Aaci_1226	COG0069	glutamate synthase activity
Aaci_1227	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
Aaci_1228	COG0137	argininosuccinate synthase activity
Aaci_1229	COG0165	Argininosuccinate lyase
Aaci_1231	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
Aaci_1232	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
Aaci_1234	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
Aaci_1243	COG1725	Transcriptional regulator
Aaci_1244	COG1131	(ABC) transporter
Aaci_1246	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
Aaci_1250	COG1250	3-hydroxyacyl-CoA dehydrogenase
Aaci_1250	COG1024	Enoyl-CoA hydratase
Aaci_1251	COG0655	NAD(P)H dehydrogenase (quinone) activity
Aaci_1252	COG1802	Transcriptional regulator
Aaci_1253	COG1584	GPR1 FUN34 yaaH family protein
Aaci_1254	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Aaci_1255	COG3906	Belongs to the UPF0473 family
Aaci_1260	COG0740	serine-type endopeptidase activity
Aaci_1261	COG1104	cysteine desulfurase activity
Aaci_1262	COG0301	tRNA thio-modification
Aaci_1266	COG0300	oxidoreductase activity
Aaci_1267	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
Aaci_1268	COG2001	Belongs to the MraZ family
Aaci_1269	COG0275	rRNA processing
Aaci_1272	COG0768	penicillin binding
Aaci_1273	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
Aaci_1274	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
Aaci_1275	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
Aaci_1276	COG0772	Belongs to the SEDS family
Aaci_1277	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
Aaci_1278	COG0812	UDP-N-acetylmuramate dehydrogenase activity
Aaci_1280	COG0492	ferredoxin-NADP+ reductase activity
Aaci_1282	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
Aaci_1286	COG3856	small basic protein
Aaci_1287	COG0849	cell division
Aaci_1288	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
Aaci_1290	COG1191	sigma factor activity
Aaci_1291	COG1191	sigma factor activity
Aaci_1292	COG1873	PFAM PRC-barrel domain
Aaci_1294	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
Aaci_1297	COG3599	regulation of cell shape
Aaci_1300	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
Aaci_1301	COG1809	phosphosulfolactate synthase activity
Aaci_1302	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
Aaci_1303	COG0564	pseudouridine synthase activity
Aaci_1304	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
Aaci_1305	COG0540	Belongs to the ATCase OTCase family
Aaci_1306	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
Aaci_1309	COG0284	orotidine-5'-phosphate decarboxylase activity
Aaci_1311	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
Aaci_1311	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Aaci_1313	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
Aaci_1315	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
Aaci_1316	COG1561	YicC-like family, N-terminal region
Aaci_1318	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
Aaci_1319	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
Aaci_1320	COG0242	peptide deformylase activity
Aaci_1321	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
Aaci_1322	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
Aaci_1322	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
Aaci_1323	COG0820	rRNA (adenine-C2-)-methyltransferase activity
Aaci_1324	COG0631	protein serine/threonine phosphatase activity
Aaci_1325	COG0515	serine threonine protein kinase
Aaci_1325	COG2815	serine threonine protein kinase
Aaci_1326	COG1162	GTPase activity
Aaci_1327	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
Aaci_1329	COG0227	Belongs to the bacterial ribosomal protein bL28 family
Aaci_1330	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
Aaci_1332	COG0688	phosphatidylethanolamine metabolic process
Aaci_1335	COG0154	amidase activity
Aaci_1336	COG0742	ribosomal rna small subunit methyltransferase
Aaci_1337	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
Aaci_1338	COG1752	Esterase of the alpha-beta hydrolase superfamily
Aaci_1340	COG0333	Belongs to the bacterial ribosomal protein bL32 family
Aaci_1342	COG0416	fatty acid biosynthetic process
Aaci_1343	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
Aaci_1344	COG1028	Short-chain dehydrogenase reductase Sdr
Aaci_1345	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
Aaci_1346	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
Aaci_1347	COG0571	ribonuclease III activity
Aaci_1348	COG1196	nuclear chromosome segregation
Aaci_1349	COG0552	protein localization to endoplasmic reticulum
Aaci_1350	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
Aaci_1351	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
Aaci_1352	COG0228	four-way junction DNA binding
Aaci_1353	COG1837	Belongs to the UPF0109 family
Aaci_1356	COG0336	Belongs to the RNA methyltransferase TrmD family
Aaci_1358	COG0564	pseudouridine synthase activity
Aaci_1360	COG0739	heme binding
Aaci_1361	COG1607	acyl-coa hydrolase
Aaci_1366	COG0335	large ribosomal subunit rRNA binding
Aaci_1368	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
Aaci_1371	COG0792	nuclease activity
Aaci_1372	COG0726	polysaccharide deacetylase
Aaci_1375	COG0045	succinate-CoA ligase (ADP-forming) activity
Aaci_1376	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
Aaci_1377	COG0758	DNA mediated transformation
Aaci_1377	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
Aaci_1381	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
Aaci_1382	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
Aaci_1383	COG4974	Belongs to the 'phage' integrase family
Aaci_1384	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
Aaci_1388	COG1677	Flagellar hook-basal body complex protein FliE
Aaci_1389	COG1766	The M ring may be actively involved in energy transduction
Aaci_1390	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
Aaci_1392	COG1157	protein secretion by the type III secretion system
Aaci_1396	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
Aaci_1399	COG1749	Flagellar hook protein flgE
Aaci_1399	COG1749	Flagellar hook protein flgE
Aaci_1402	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
Aaci_1403	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
Aaci_1403	COG1776	CheC inhibitor of MCP methylation
Aaci_1404	COG2201	protein-glutamate methylesterase activity
Aaci_1405	COG3190	flagellar
Aaci_1406	COG1338	Plays a role in the flagellum-specific transport system
Aaci_1407	COG1987	bacterial-type flagellum assembly
Aaci_1409	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
Aaci_1410	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
Aaci_1411	COG1419	protein localization to endoplasmic reticulum
Aaci_1412	COG0455	bacterial-type flagellum organization
Aaci_1414	COG2198	Histidine kinase
Aaci_1414	COG0643	Histidine kinase
Aaci_1415	COG0835	chemotaxis
Aaci_1416	COG1776	CheC inhibitor of MCP methylation
Aaci_1417	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
Aaci_1419	COG0052	Belongs to the universal ribosomal protein uS2 family
Aaci_1421	COG0528	UMP kinase activity
Aaci_1422	COG0233	cytoplasmic translational termination
Aaci_1423	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
Aaci_1424	COG4589	Belongs to the CDS family
Aaci_1425	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
Aaci_1426	COG0750	zinc metalloprotease
Aaci_1427	COG2176	DNA-directed DNA polymerase activity
Aaci_1428	COG0346	lactoylglutathione lyase activity
Aaci_1431	COG0779	Required for maturation of 30S ribosomal subunits
Aaci_1432	COG0195	Participates in both transcription termination and antitermination
Aaci_1433	COG2740	Nucleic-acid-binding protein implicated in transcription termination
Aaci_1436	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
Aaci_1437	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
Aaci_1438	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
Aaci_1439	COG0196	riboflavin kinase activity
Aaci_1441	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
Aaci_1442	COG1185	polyribonucleotide nucleotidyltransferase activity
Aaci_1443	COG0726	polysaccharide deacetylase
Aaci_1444	COG0612	Peptidase, M16
Aaci_1446	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
Aaci_1447	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
Aaci_1448	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
Aaci_1449	COG0527	aspartate kinase activity
Aaci_1452	COG1960	acyl-CoA dehydrogenase activity
Aaci_1454	COG1012	belongs to the aldehyde dehydrogenase family
Aaci_1455	COG1024	Enoyl-CoA hydratase
Aaci_1456	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Aaci_1457	COG0183	Belongs to the thiolase family
Aaci_1460	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
Aaci_1461	COG0740	serine-type endopeptidase activity
Aaci_1468	COG1426	Protein conserved in bacteria
Aaci_1469	COG1666	GTP binding
Aaci_1470	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
Aaci_1472	COG0513	Belongs to the DEAD box helicase family
Aaci_1473	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
Aaci_1475	COG1418	mRNA catabolic process
Aaci_1476	COG2359	stage V sporulation protein S
Aaci_1482	COG0189	ligase activity
Aaci_1484	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Aaci_1486	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
Aaci_1487	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
Aaci_1488	COG2136	Putative SAM-dependent methyltransferase
Aaci_1488	COG2521	methyltransferase
Aaci_1489	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
Aaci_1490	COG1923	regulation of RNA biosynthetic process
Aaci_1500	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
Aaci_1505	COG1136	(ABC) transporter
Aaci_1506	COG1136	(ABC) transporter
Aaci_1506	COG0577	efflux transmembrane transporter activity
Aaci_1522	COG3328	transposase activity
Aaci_1534	COG1595	DNA-templated transcription, initiation
Aaci_1550	COG3328	transposase activity
Aaci_1557	COG0473	3-isopropylmalate dehydrogenase activity
Aaci_1558	COG0697	spore germination
Aaci_1562	COG0697	spore germination
Aaci_1563	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
Aaci_1564	COG2244	polysaccharide biosynthetic process
Aaci_1566	COG0464	growth
Aaci_1570	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
Aaci_1571	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
Aaci_1572	COG0789	Transcriptional regulator
Aaci_1573	COG0174	glutamine synthetase
Aaci_1574	COG1609	Transcriptional regulator
Aaci_1575	COG2721	sulfolactate sulfo-lyase activity
Aaci_1576	COG3718	enzyme involved in inositol metabolism
Aaci_1577	COG0246	Mannitol dehydrogenase
Aaci_1578	COG2814	Major facilitator Superfamily
Aaci_1579	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
Aaci_1580	COG0561	phosphatase activity
Aaci_1581	COG0423	glycine-tRNA ligase activity
Aaci_1583	COG0646	methionine synthase
Aaci_1583	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
Aaci_1585	COG3706	GGDEF domain
Aaci_1590	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
Aaci_1591	COG2086	electron transfer activity
Aaci_1592	COG1309	transcriptional regulator
Aaci_1593	COG0247	lactate metabolic process
Aaci_1593	COG2181	nitrate reductase activity
Aaci_1594	COG1024	Enoyl-CoA hydratase
Aaci_1594	COG1250	3-hydroxyacyl-CoA dehydrogenase
Aaci_1595	COG0183	Belongs to the thiolase family
Aaci_1596	COG1960	acyl-CoA dehydrogenase activity
Aaci_1597	COG0318	PFAM AMP-dependent synthetase and ligase
Aaci_1599	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
Aaci_1600	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
Aaci_1601	COG0531	amino acid
Aaci_1602	COG1289	transmembrane transporter activity
Aaci_1606	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
Aaci_1607	COG0517	IMP dehydrogenase activity
Aaci_1607	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
Aaci_1608	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
Aaci_1608	COG0574	Belongs to the PEP-utilizing enzyme family
Aaci_1609	COG1494	fructose-1,6-bisphosphatase
Aaci_1612	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
Aaci_1617	COG1942	4-Oxalocrotonate Tautomerase
Aaci_1619	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Aaci_1624	COG1414	Transcriptional regulator
Aaci_1627	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
Aaci_1628	COG0174	glutamine synthetase
Aaci_1629	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
Aaci_1630	COG0445	tRNA wobble uridine modification
Aaci_1632	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Aaci_1635	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
Aaci_1636	COG1181	Belongs to the D-alanine--D-alanine ligase family
Aaci_1637	COG3935	DnaD domain protein
Aaci_1638	COG0017	Asparaginyl-tRNA synthetase
Aaci_1639	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Aaci_1643	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
Aaci_1645	COG0402	S-adenosylhomocysteine deaminase activity
Aaci_1646	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
Aaci_1647	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
Aaci_1648	COG1793	dna ligase
Aaci_1648	COG3285	dna ligase
Aaci_1650	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
Aaci_1651	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
Aaci_1651	COG1199	ATP-dependent helicase activity
Aaci_1654	COG0617	tRNA 3'-terminal CCA addition
Aaci_1655	COG0438	transferase activity, transferring glycosyl groups
Aaci_1656	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
Aaci_1657	COG1694	Mazg nucleotide pyrophosphohydrolase
Aaci_1659	COG3314	Sporulation integral membrane protein YlbJ
Aaci_1660	COG1968	undecaprenyl-diphosphatase activity
Aaci_1661	COG3949	Membrane
Aaci_1662	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
Aaci_1665	COG0287	Prephenate dehydrogenase
Aaci_1666	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
Aaci_1667	COG0159	tryptophan synthase activity
Aaci_1668	COG0133	tryptophan synthase activity
Aaci_1669	COG0135	phosphoribosylanthranilate isomerase activity
Aaci_1670	COG0134	indole-3-glycerol-phosphate synthase activity
Aaci_1671	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
Aaci_1672	COG4401	Chorismate mutase type I
Aaci_1673	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
Aaci_1674	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
Aaci_1677	COG1363	Peptidase, m42
Aaci_1681	COG0791	NLP P60 protein
Aaci_1681	COG1388	LysM domain
Aaci_1683	COG0714	Associated with various cellular activities
Aaci_1686	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
Aaci_1687	COG0517	IMP dehydrogenase activity
Aaci_1689	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
Aaci_1691	COG0105	UTP biosynthetic process
Aaci_1692	COG0142	geranyltranstransferase activity
Aaci_1693	COG2226	methyltransferase
Aaci_1696	COG1064	alcohol dehydrogenase
Aaci_1697	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
Aaci_1698	COG0509	glycine decarboxylation via glycine cleavage system
Aaci_1700	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
Aaci_1701	COG1160	GTP binding
Aaci_1703	COG0539	negative regulation of cytoplasmic translation
Aaci_1705	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
Aaci_1707	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
Aaci_1709	COG3409	Peptidoglycan-binding domain 1 protein
Aaci_1709	COG3773	Cell wall hydrolase
Aaci_1711	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
Aaci_1712	COG4862	establishment of competence for transformation
Aaci_1713	COG1609	Transcriptional regulator
Aaci_1715	COG0210	DNA helicase
Aaci_1715	COG0210	DNA helicase
Aaci_1717	COG2226	methyltransferase
Aaci_1719	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Aaci_1722	COG2339	peptidase activity
Aaci_1724	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
Aaci_1727	COG5002	protein histidine kinase activity
Aaci_1728	COG0745	RESPONSE REGULATOR receiver
Aaci_1730	COG1187	pseudouridine synthase activity
Aaci_1731	COG0700	Nucleoside recognition
Aaci_1732	COG2715	membrane protein required for spore maturation
Aaci_1733	COG3874	Sporulation protein YtfJ
Aaci_1735	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
Aaci_1736	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
Aaci_1737	COG1994	Peptidase M50
Aaci_1742	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
Aaci_1744	COG1191	sigma factor activity
Aaci_1746	COG1366	Belongs to the anti-sigma-factor antagonist family
Aaci_1748	COG1686	Belongs to the peptidase S11 family
Aaci_1749	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
Aaci_1750	COG4974	Belongs to the 'phage' integrase family
Aaci_1753	COG1379	DNA repair
Aaci_1754	COG0494	nUDIX hydrolase
Aaci_1756	COG0321	lipoyl(octanoyl) transferase activity
Aaci_1757	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
Aaci_1758	COG0315	cyclic pyranopterin monophosphate synthase activity
Aaci_1759	COG0314	molybdopterin synthase activity
Aaci_1760	COG1388	LysM domain
Aaci_1760	COG3858	chitin binding
Aaci_1768	COG0750	zinc metalloprotease
Aaci_1769	COG0497	DNA recombination
Aaci_1770	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
Aaci_1772	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
Aaci_1776	COG1570	exodeoxyribonuclease VII activity
Aaci_1777	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
Aaci_1778	COG0492	ferredoxin-NADP+ reductase activity
Aaci_1783	COG1302	Protein conserved in bacteria
Aaci_1784	COG0439	Biotin carboxylase
Aaci_1785	COG0511	ligase activity, forming carbon-carbon bonds
Aaci_1793	COG3854	ATPases associated with a variety of cellular activities
Aaci_1795	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
Aaci_1796	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
Aaci_1797	COG0406	alpha-ribazole phosphatase activity
Aaci_1799	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
Aaci_1800	COG0404	The glycine cleavage system catalyzes the degradation of glycine
Aaci_1801	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
Aaci_1803	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
Aaci_1804	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
Aaci_1813	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
Aaci_1815	COG0211	Belongs to the bacterial ribosomal protein bL27 family
Aaci_1816	COG2868	ribosomal protein
Aaci_1818	COG1994	Peptidase M50
Aaci_1820	COG2894	cell division
Aaci_1821	COG0850	regulation of cytokinetic process
Aaci_1824	COG1077	Cell shape determining protein MreB Mrl
Aaci_1825	COG2003	Belongs to the UPF0758 family
Aaci_1828	COG3583	domain protein
Aaci_1828	COG3584	3D domain protein
Aaci_1829	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
Aaci_1830	COG0285	dihydrofolate synthase activity
Aaci_1831	COG0525	valine-tRNA ligase activity
Aaci_1835	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
Aaci_1836	COG0113	porphobilinogen synthase activity
Aaci_1838	COG0181	hydroxymethylbilane synthase activity
Aaci_1840	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
Aaci_1841	COG0218	Necessary for normal cell division and for the maintenance of normal septation
Aaci_1843	COG1067	ATP-dependent peptidase activity
Aaci_1843	COG0470	DNA polymerase III
Aaci_1844	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
Aaci_1845	COG0740	serine-type endopeptidase activity
Aaci_1846	COG0544	peptidyl-prolyl cis-trans isomerase activity
Aaci_1847	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
Aaci_1848	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
Aaci_1849	COG1846	Transcriptional regulator
Aaci_1850	COG1960	acyl-CoA dehydrogenase activity
Aaci_1854	COG2197	response regulator
Aaci_1855	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
Aaci_1857	COG2188	Transcriptional regulator
Aaci_1861	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
Aaci_1862	COG1053	succinate dehydrogenase
Aaci_1863	COG2009	succinate dehydrogenase
Aaci_1864	COG0322	excinuclease ABC activity
Aaci_1866	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Aaci_1868	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
Aaci_1870	COG0387	Pfam Sodium calcium exchanger
Aaci_1876	COG0463	Glycosyl transferase, family 2
Aaci_1878	COG1846	Transcriptional regulator
Aaci_1881	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
Aaci_1882	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
Aaci_1887	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
Aaci_1888	COG0647	UMP catabolic process
Aaci_1889	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Aaci_1892	COG2076	Multidrug Resistance protein
Aaci_1893	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
Aaci_1896	COG4608	Belongs to the ABC transporter superfamily
Aaci_1899	COG0601	transmembrane transport
Aaci_1905	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
Aaci_1906	COG0704	Plays a role in the regulation of phosphate uptake
Aaci_1908	COG1388	LysM domain
Aaci_1908	COG0791	NLP P60 protein
Aaci_1909	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
Aaci_1917	COG0596	Alpha beta hydrolase
Aaci_1918	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
Aaci_1919	COG1169	isochorismate synthase
Aaci_1921	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
Aaci_1922	COG1575	Belongs to the MenA family. Type 1 subfamily
Aaci_1923	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
Aaci_1924	COG2427	Protein of unknown function (DUF1641)
Aaci_1925	COG3383	formate dehydrogenase (NAD+) activity
Aaci_1926	COG1331	Highly conserved protein containing a thioredoxin domain
Aaci_1927	COG1331	Highly conserved protein containing a thioredoxin domain
Aaci_1928	COG0456	acetyltransferase
Aaci_1929	COG0697	spore germination
Aaci_1931	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
Aaci_1932	COG0351	phosphomethylpyrimidine kinase
Aaci_1933	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
Aaci_1934	COG0352	thiamine-phosphate diphosphorylase activity
Aaci_1935	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
Aaci_1936	COG4988	ABC transporter
Aaci_1937	COG1294	oxidase, subunit
Aaci_1938	COG1271	oxidase subunit
Aaci_1939	COG0477	Major facilitator Superfamily
Aaci_1940	COG1846	Transcriptional regulator
Aaci_1942	COG1120	ATPase activity
Aaci_1943	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Aaci_1944	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
Aaci_1948	COG1733	regulation of RNA biosynthetic process
Aaci_1949	COG0720	synthase
Aaci_1950	COG0602	queuosine metabolic process
Aaci_1953	COG0248	Ppx GppA phosphatase
Aaci_1954	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
Aaci_1958	COG0306	phosphate transporter
Aaci_1959	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
Aaci_1962	COG0697	spore germination
Aaci_1966	COG4191	Histidine kinase
Aaci_1968	COG1902	pentaerythritol trinitrate reductase activity
Aaci_1969	COG5002	protein histidine kinase activity
Aaci_1973	COG0010	Belongs to the arginase family
Aaci_1974	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
Aaci_1975	COG2384	SAM-dependent methyltransferase
Aaci_1977	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
Aaci_1978	COG0358	DNA primase activity
Aaci_1979	COG1381	Involved in DNA repair and RecF pathway recombination
Aaci_1981	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
Aaci_1983	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
Aaci_1984	COG1480	7TM receptor with intracellular HD hydrolase
Aaci_1985	COG1702	phosphate starvation-inducible protein PhoH
Aaci_1988	COG1610	YqeY-like protein
Aaci_1989	COG0828	Belongs to the bacterial ribosomal protein bS21 family
Aaci_1992	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Aaci_1993	COG1385	rRNA (uridine-N3-)-methyltransferase activity
Aaci_1994	COG2264	protein methyltransferase activity
Aaci_1995	COG0484	heat shock protein binding
Aaci_1996	COG0443	Heat shock 70 kDa protein
Aaci_1997	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
Aaci_1998	COG1420	regulation of RNA biosynthetic process
Aaci_1999	COG0635	Involved in the biosynthesis of porphyrin-containing compound
Aaci_2000	COG0481	GTPase activity
Aaci_2003	COG0741	lytic transglycosylase activity
Aaci_2005	COG0268	Binds directly to 16S ribosomal RNA
Aaci_2008	COG1252	NADH dehydrogenase
Aaci_2010	COG1596	polysaccharide export
Aaci_2010	COG1555	photosystem II stabilization
Aaci_2011	COG1321	iron dependent repressor
Aaci_2012	COG2226	methyltransferase
Aaci_2012	COG0596	Alpha beta hydrolase
Aaci_2012	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
Aaci_2013	COG0799	negative regulation of ribosome biogenesis
Aaci_2014	COG1713	HD superfamily hydrolase involved in NAD metabolism
Aaci_2015	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
Aaci_2016	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
Aaci_2017	COG1160	GTP binding
Aaci_2020	COG1191	sigma factor activity
Aaci_2021	COG2226	methyltransferase
Aaci_2024	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
Aaci_2025	COG4472	Bacterial protein of unknown function (DUF965)
Aaci_2026	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
Aaci_2027	COG0628	permease
Aaci_2029	COG1104	cysteine desulfurase activity
Aaci_2030	COG1959	2 iron, 2 sulfur cluster binding
Aaci_2033	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
Aaci_2035	COG0318	PFAM AMP-dependent synthetase and ligase
Aaci_2037	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
Aaci_2038	COG0124	histidyl-tRNA synthetase
Aaci_2040	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
Aaci_2043	COG1131	(ABC) transporter
Aaci_2045	COG2814	Major facilitator Superfamily
Aaci_2047	COG1175	transmembrane transport
Aaci_2048	COG0395	ABC-type sugar transport system, permease component
Aaci_2051	COG1024	Enoyl-CoA hydratase
Aaci_2052	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
Aaci_2053	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Aaci_2054	COG0511	ligase activity, forming carbon-carbon bonds
Aaci_2056	COG1960	acyl-CoA dehydrogenase activity
Aaci_2059	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
Aaci_2060	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
Aaci_2063	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
Aaci_2064	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
Aaci_2064	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
Aaci_2065	COG1250	3-hydroxyacyl-CoA dehydrogenase
Aaci_2067	COG1028	Short-chain dehydrogenase reductase Sdr
Aaci_2069	COG2211	Major facilitator Superfamily
Aaci_2071	COG0667	Aldo Keto reductase
Aaci_2072	COG0303	'Molybdopterin
Aaci_2073	COG1210	Utp--glucose-1-phosphate uridylyltransferase
Aaci_2076	COG1074	ATP-dependent DNA helicase activity
Aaci_2077	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
Aaci_2078	COG0477	Major facilitator Superfamily
Aaci_2079	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Aaci_2080	COG0531	amino acid
Aaci_2082	COG3290	protein histidine kinase activity
Aaci_2082	COG3829	transcription factor binding
Aaci_2083	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
Aaci_2085	COG1686	Belongs to the peptidase S11 family
Aaci_2089	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
Aaci_2094	COG3300	MHYT domain
Aaci_2094	COG5001	Diguanylate cyclase
Aaci_2097	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
Aaci_2098	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
Aaci_2099	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
Aaci_2099	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
Aaci_2100	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
Aaci_2101	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Aaci_2102	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Aaci_2104	COG2244	polysaccharide biosynthetic process
Aaci_2106	COG2203	Gaf domain
Aaci_2106	COG5001	Diguanylate cyclase
Aaci_2106	COG4251	negative regulation of phosphorylation
Aaci_2106	COG3706	GGDEF domain
Aaci_2110	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
Aaci_2112	COG1191	sigma factor activity
Aaci_2113	COG2255	four-way junction helicase activity
Aaci_2114	COG0632	four-way junction helicase activity
Aaci_2115	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
Aaci_2117	COG0217	transcriptional regulatory protein
Aaci_2119	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Aaci_2119	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
Aaci_2123	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
Aaci_2124	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
Aaci_2125	COG1193	negative regulation of DNA recombination
Aaci_2128	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
Aaci_2129	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Aaci_2129	COG0072	phenylalanine-tRNA ligase activity
Aaci_2130	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
Aaci_2132	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
Aaci_2133	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
Aaci_2134	COG1830	Aldolase
Aaci_2135	COG0205	6-phosphofructokinase activity
Aaci_2136	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
Aaci_2137	COG0840	transmembrane signaling receptor activity
Aaci_2138	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
Aaci_2139	COG3842	ATPase activity
Aaci_2142	COG0579	oxidoreductase
Aaci_2143	COG0508	dehydrogenase complex catalyzes the overall conversion of
Aaci_2144	COG0567	Dehydrogenase, E1 component
Aaci_2146	COG0714	Associated with various cellular activities
Aaci_2149	COG1482	cell wall glycoprotein biosynthetic process
Aaci_2150	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
Aaci_2154	COG0673	inositol 2-dehydrogenase activity
Aaci_2155	COG1082	Xylose isomerase domain protein TIM barrel
Aaci_2160	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Aaci_2161	COG0697	spore germination
Aaci_2162	COG1214	PFAM Peptidase M22, glycoprotease
Aaci_2162	COG0456	acetyltransferase
Aaci_2163	COG2267	carboxylic ester hydrolase activity
Aaci_2164	COG0531	amino acid
Aaci_2165	COG3546	catalase activity
Aaci_2168	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
Aaci_2169	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Aaci_2170	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
Aaci_2171	COG0291	Belongs to the bacterial ribosomal protein bL35 family
Aaci_2175	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
Aaci_2179	COG1070	Carbohydrate kinase
Aaci_2180	COG2115	Belongs to the xylose isomerase family
Aaci_2182	COG1408	metallophosphoesterase
Aaci_2186	COG0300	oxidoreductase activity
Aaci_2197	COG1278	Cold shock
Aaci_2200	COG0667	Aldo Keto reductase
Aaci_2201	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
Aaci_2205	COG4989	oxidoreductase activity
Aaci_2206	COG1082	Xylose isomerase domain protein TIM barrel
Aaci_2208	COG2154	pterin-4-alpha-carbinolamine dehydratase
Aaci_2211	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
Aaci_2215	COG0577	efflux transmembrane transporter activity
Aaci_2216	COG1136	(ABC) transporter
Aaci_2219	COG0517	IMP dehydrogenase activity
Aaci_2221	COG0372	Belongs to the citrate synthase family
Aaci_2222	COG1971	Probably functions as a manganese efflux pump
Aaci_2223	COG0285	dihydrofolate synthase activity
Aaci_2224	COG0066	3-isopropylmalate dehydratase activity
Aaci_2225	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
Aaci_2226	COG0473	3-isopropylmalate dehydrogenase activity
Aaci_2227	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
Aaci_2228	COG0440	acetolactate synthase activity
Aaci_2229	COG0028	Belongs to the TPP enzyme family
Aaci_2230	COG0129	dihydroxy-acid dehydratase activity
Aaci_2233	COG0460	homoserine dehydrogenase
Aaci_2234	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Aaci_2237	COG1653	transport
Aaci_2242	COG0450	alkyl hydroperoxide reductase
Aaci_2243	COG1959	2 iron, 2 sulfur cluster binding
Aaci_2245	COG1388	LysM domain
Aaci_2245	COG3858	chitin binding
Aaci_2247	COG0833	amino acid
Aaci_2254	COG1132	(ABC) transporter
Aaci_2255	COG1132	(ABC) transporter
Aaci_2258	COG0747	negative chemotaxis
Aaci_2259	COG0601	transmembrane transport
Aaci_2260	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Aaci_2261	COG0747	negative chemotaxis
Aaci_2262	COG4608	Belongs to the ABC transporter superfamily
Aaci_2263	COG0444	Belongs to the ABC transporter superfamily
Aaci_2264	COG0745	RESPONSE REGULATOR receiver
Aaci_2266	COG0095	Lipoate-protein ligase
Aaci_2267	COG5002	protein histidine kinase activity
Aaci_2268	COG0745	RESPONSE REGULATOR receiver
Aaci_2269	COG0583	DNA-binding transcription factor activity
Aaci_2271	COG0708	Exodeoxyribonuclease III
Aaci_2274	COG2390	Transcriptional regulator
Aaci_2275	COG1072	(Pantothenic acid kinase))
Aaci_2276	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Aaci_2277	COG1879	ABC-type sugar transport system periplasmic component
Aaci_2278	COG1172	Belongs to the binding-protein-dependent transport system permease family
Aaci_2279	COG1129	ABC transporter
Aaci_2280	COG1869	D-ribose catabolic process
Aaci_2281	COG1609	Transcriptional regulator
Aaci_2282	COG1132	(ABC) transporter
Aaci_2283	COG1132	(ABC) transporter
Aaci_2286	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
Aaci_2288	COG1218	3'(2'),5'-bisphosphate nucleotidase
Aaci_2289	COG1312	Catalyzes the dehydration of D-mannonate
Aaci_2290	COG0352	thiamine-phosphate diphosphorylase activity
Aaci_2292	COG1929	Belongs to the glycerate kinase type-1 family
Aaci_2302	COG2814	Major facilitator Superfamily
Aaci_2305	COG0840	transmembrane signaling receptor activity
Aaci_2306	COG1653	transport
Aaci_2316	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
Aaci_2323	COG1349	DNA-binding transcription factor activity
Aaci_2324	COG1085	galactose-1-phosphate uridylyltransferase
Aaci_2325	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
Aaci_2330	COG1063	alcohol dehydrogenase
Aaci_2331	COG0668	transmembrane transport
Aaci_2332	COG0768	penicillin binding
Aaci_2338	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
Aaci_2341	COG1827	regulation of RNA biosynthetic process
Aaci_2343	COG0237	dephospho-CoA kinase activity
Aaci_2344	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
Aaci_2346	COG0077	Prephenate dehydratase
Aaci_2346	COG1605	Chorismate mutase
Aaci_2348	COG0538	isocitrate dehydrogenase activity
Aaci_2350	COG0745	RESPONSE REGULATOR receiver
Aaci_2351	COG0180	Tryptophanyl-tRNA synthetase
Aaci_2352	COG0469	pyruvate kinase activity
Aaci_2353	COG0825	malonyl-CoA metabolic process
Aaci_2354	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
Aaci_2356	COG0587	DNA-directed DNA polymerase activity
Aaci_2357	COG4109	DRTGG domain
Aaci_2358	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
Aaci_2362	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
Aaci_2363	COG1438	arginine binding
Aaci_2364	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
Aaci_2368	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
Aaci_2369	COG3679	Belongs to the UPF0342 family
Aaci_2370	COG2346	COG2346, Truncated hemoglobins
Aaci_2372	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
Aaci_2375	COG2267	carboxylic ester hydrolase activity
Aaci_2376	COG1045	serine acetyltransferase
Aaci_2377	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Aaci_2379	COG4496	protein, YerC YecD
Aaci_2381	COG2132	Multicopper oxidase
Aaci_2390	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
Aaci_2394	COG1063	alcohol dehydrogenase
Aaci_2395	COG1960	acyl-CoA dehydrogenase activity
Aaci_2396	COG0318	PFAM AMP-dependent synthetase and ligase
Aaci_2397	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
Aaci_2398	COG1028	Short-chain dehydrogenase reductase Sdr
Aaci_2399	COG0446	pyridine nucleotide-disulphide oxidoreductase
Aaci_2399	COG1902	pentaerythritol trinitrate reductase activity
Aaci_2400	COG0318	PFAM AMP-dependent synthetase and ligase
Aaci_2401	COG1960	acyl-CoA dehydrogenase activity
Aaci_2402	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
Aaci_2404	COG1376	ErfK ybiS ycfS ynhG family protein
Aaci_2412	COG1028	Short-chain dehydrogenase reductase Sdr
Aaci_2413	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
Aaci_2415	COG0667	Aldo Keto reductase
Aaci_2417	COG0840	transmembrane signaling receptor activity
Aaci_2419	COG0788	formyltetrahydrofolate deformylase activity
Aaci_2422	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
Aaci_2422	COG1587	Uroporphyrinogen-III synthase
Aaci_2423	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
Aaci_2424	COG0175	sulfate reduction
Aaci_2427	COG1648	precorrin-2 dehydrogenase activity
Aaci_2427	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
Aaci_2428	COG2814	Major facilitator Superfamily
Aaci_2429	COG1566	PFAM secretion protein HlyD family protein
Aaci_2431	COG1215	transferase activity, transferring glycosyl groups
Aaci_2432	COG3103	Sh3 type 3 domain protein
Aaci_2432	COG1388	LysM domain
Aaci_2432	COG0791	NLP P60 protein
Aaci_2433	COG1809	phosphosulfolactate synthase activity
Aaci_2435	COG0531	amino acid
Aaci_2438	COG0697	spore germination
Aaci_2439	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Aaci_2442	COG1562	ergosterol biosynthetic process
Aaci_2443	COG1657	PFAM Prenyltransferase squalene oxidase
Aaci_2444	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Aaci_2446	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
Aaci_2447	COG1304	FMN binding
Aaci_2448	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
Aaci_2455	COG2132	Multicopper oxidase
Aaci_2456	COG2132	Multicopper oxidase
Aaci_2458	COG0395	ABC-type sugar transport system, permease component
Aaci_2459	COG1175	transmembrane transport
Aaci_2462	COG0673	inositol 2-dehydrogenase activity
Aaci_2463	COG1609	Transcriptional regulator
Aaci_2468	COG0004	ammonium transporteR
Aaci_2469	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
Aaci_2472	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Aaci_2473	COG0601	transmembrane transport
Aaci_2474	COG4166	transmembrane transport
Aaci_2475	COG3291	Pkd domain containing protein
Aaci_2476	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
Aaci_2477	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
Aaci_2480	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
Aaci_2481	COG2022	thiamine diphosphate biosynthetic process
Aaci_2483	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Aaci_2484	COG0352	thiamine-phosphate diphosphorylase activity
Aaci_2485	COG1227	inorganic diphosphatase activity
Aaci_2487	COG2814	Major facilitator Superfamily
Aaci_2490	COG0789	Transcriptional regulator
Aaci_2494	COG1090	epimerase
Aaci_2495	COG2271	Major facilitator Superfamily
Aaci_2501	COG0693	protein deglycase activity
Aaci_2502	COG0840	transmembrane signaling receptor activity
Aaci_2503	COG0531	amino acid
Aaci_2504	COG1012	belongs to the aldehyde dehydrogenase family
Aaci_2509	COG0457	Tetratricopeptide repeat
Aaci_2509	COG0463	Glycosyl transferase, family 2
Aaci_2511	COG0583	DNA-binding transcription factor activity
Aaci_2515	COG2271	Major facilitator Superfamily
Aaci_2517	COG1063	alcohol dehydrogenase
Aaci_2519	COG0450	alkyl hydroperoxide reductase
Aaci_2520	COG0735	belongs to the Fur family
Aaci_2521	COG0596	Alpha beta hydrolase
Aaci_2523	COG1113	amino acid transport
Aaci_2525	COG2204	response regulator
Aaci_2526	COG0277	FAD linked oxidase domain protein
Aaci_2527	COG2271	Major facilitator Superfamily
Aaci_2528	COG2267	carboxylic ester hydrolase activity
Aaci_2529	COG1620	l-lactate permease
Aaci_2530	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
Aaci_2531	COG1414	Transcriptional regulator
Aaci_2532	COG0277	FAD linked oxidase domain protein
Aaci_2533	COG0247	lactate metabolic process
Aaci_2534	COG0277	FAD linked oxidase domain protein
Aaci_2535	COG1215	transferase activity, transferring glycosyl groups
Aaci_2538	COG0640	Transcriptional regulator
Aaci_2546	COG2255	four-way junction helicase activity
Aaci_2550	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
Aaci_2551	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
Aaci_2553	COG0653	protein targeting
Aaci_2554	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
Aaci_2557	COG1216	Glycosyl transferase, family 2
Aaci_2558	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
Aaci_2559	COG0457	Tetratricopeptide repeat
Aaci_2559	COG0463	Glycosyl transferase, family 2
Aaci_2561	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
Aaci_2562	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
Aaci_2568	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
Aaci_2569	COG5002	protein histidine kinase activity
Aaci_2570	COG0745	RESPONSE REGULATOR receiver
Aaci_2573	COG2197	response regulator
Aaci_2574	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
Aaci_2577	COG2814	Major facilitator Superfamily
Aaci_2578	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
Aaci_2579	COG0154	amidase activity
Aaci_2580	COG0315	cyclic pyranopterin monophosphate synthase activity
Aaci_2580	COG0521	Mo-molybdopterin cofactor biosynthetic process
Aaci_2581	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
Aaci_2582	COG1073	alpha beta
Aaci_2585	COG0384	phenazine biosynthesis protein PhzF
Aaci_2586	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
Aaci_2588	COG1187	pseudouridine synthase activity
Aaci_2595	COG0667	Aldo Keto reductase
Aaci_2596	COG0785	Cytochrome C biogenesis protein
Aaci_2597	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Aaci_2605	COG0477	Major facilitator Superfamily
Aaci_2606	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
Aaci_2607	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
Aaci_2610	COG2814	Major facilitator Superfamily
Aaci_2613	COG0803	Belongs to the bacterial solute-binding protein 9 family
Aaci_2614	COG1121	(ABC) transporter
Aaci_2617	COG1607	acyl-coa hydrolase
Aaci_2620	COG3300	MHYT domain
Aaci_2620	COG5001	Diguanylate cyclase
Aaci_2621	COG0673	inositol 2-dehydrogenase activity
Aaci_2624	COG2372	response to copper ion
Aaci_2624	COG1276	copper resistance
Aaci_2625	COG4549	nuclear export factor GLE1
Aaci_2626	COG0306	phosphate transporter
Aaci_2631	COG0671	phosphoesterase, PA-phosphatase related
Aaci_2634	COG1595	DNA-templated transcription, initiation
Aaci_2639	COG1937	Protein conserved in bacteria
Aaci_2641	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
Aaci_2641	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Aaci_2642	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
Aaci_2642	COG0425	Belongs to the sulfur carrier protein TusA family
Aaci_2643	COG2210	Belongs to the sulfur carrier protein TusA family
Aaci_2644	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
Aaci_2645	COG0730	response to heat
Aaci_2650	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
Aaci_2651	COG1518	maintenance of DNA repeat elements
Aaci_2653	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
Aaci_2656	COG0338	D12 class N6 adenine-specific DNA methyltransferase
Aaci_2658	COG1937	Protein conserved in bacteria
Aaci_2659	COG1302	Protein conserved in bacteria
Aaci_2662	COG1302	Protein conserved in bacteria
Aaci_2663	COG1522	sequence-specific DNA binding
Aaci_2664	COG0436	Aminotransferase
Aaci_2666	COG1064	alcohol dehydrogenase
Aaci_2667	COG1309	transcriptional regulator
Aaci_2668	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
Aaci_2669	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
Aaci_2670	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
Aaci_2671	COG4856	YbbR-like protein
Aaci_2672	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
Aaci_2674	COG0726	polysaccharide deacetylase
Aaci_2676	COG0489	protein tyrosine kinase activity
Aaci_2678	COG0860	N-Acetylmuramoyl-L-alanine amidase
Aaci_2679	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Aaci_2680	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
Aaci_2681	COG0101	tRNA pseudouridine synthase activity
Aaci_2682	COG0203	ribosomal protein L17
Aaci_2683	COG0202	RNA polymerase activity
Aaci_2684	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
Aaci_2685	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
Aaci_2686	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
Aaci_2687	COG0257	Belongs to the bacterial ribosomal protein bL36 family
Aaci_2688	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
Aaci_2690	COG0563	adenylate kinase activity
Aaci_2691	COG0201	protein transport
Aaci_2693	COG1841	ribosomal large subunit assembly
Aaci_2694	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
Aaci_2695	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
Aaci_2696	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
Aaci_2697	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
Aaci_2698	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
Aaci_2699	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
Aaci_2700	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
Aaci_2701	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
Aaci_2702	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
Aaci_2703	COG0255	Belongs to the universal ribosomal protein uL29 family
Aaci_2704	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
Aaci_2705	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
Aaci_2706	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
Aaci_2707	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
Aaci_2708	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
Aaci_2709	COG0089	rRNA binding
Aaci_2710	COG0088	Forms part of the polypeptide exit tunnel
Aaci_2711	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
Aaci_2712	COG0051	transcription antitermination factor activity, RNA binding
Aaci_2713	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
Aaci_2714	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
Aaci_2715	COG0049	tRNA binding
Aaci_2717	COG1358	cellular component organization or biogenesis
Aaci_2718	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
Aaci_2719	COG0085	RNA polymerase activity
Aaci_2720	COG2813	Specifically methylates the guanine in position
Aaci_2722	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
Aaci_2723	COG0081	regulation of translation
Aaci_2724	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
Aaci_2725	COG0250	Participates in transcription elongation, termination and antitermination
Aaci_2727	COG0267	Belongs to the bacterial ribosomal protein bL33 family
Aaci_2730	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Aaci_2731	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
Aaci_2732	COG0215	cysteine-tRNA ligase activity
Aaci_2734	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
Aaci_2735	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
Aaci_2736	COG4956	integral membrane protein (PIN domain superfamily)
Aaci_2737	COG1183	phosphatidylcholine synthase activity
Aaci_2738	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
Aaci_2739	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
Aaci_2740	COG0542	response to heat
Aaci_2741	COG3869	Catalyzes the specific phosphorylation of arginine residues in
Aaci_2742	COG3880	PFAM UvrB UvrC protein
Aaci_2743	COG4463	regulation of RNA biosynthetic process
Aaci_2745	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
Aaci_2746	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
Aaci_2747	COG4786	Flagellar basal body rod
Aaci_2748	COG4786	Flagellar basal body rod
Aaci_2750	COG1609	Transcriptional regulator
Aaci_2751	COG0739	heme binding
Aaci_2753	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
Aaci_2756	COG0355	proton-transporting ATP synthase activity, rotational mechanism
Aaci_2757	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
Aaci_2758	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
Aaci_2759	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
Aaci_2760	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
Aaci_2761	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
Aaci_2762	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
Aaci_2763	COG0356	it plays a direct role in the translocation of protons across the membrane
Aaci_2766	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
Aaci_2767	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
Aaci_2768	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
Aaci_2770	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
Aaci_2771	COG1971	Probably functions as a manganese efflux pump
Aaci_2773	COG3619	membrane
Aaci_2777	COG0009	L-threonylcarbamoyladenylate synthase
Aaci_2779	COG2890	protein-(glutamine-N5) methyltransferase activity
Aaci_2780	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
Aaci_2781	COG0254	rRNA binding
Aaci_2782	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
Aaci_2783	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
Aaci_2785	COG0504	CTP synthase activity
Aaci_2786	COG3343	RNA polymerase activity
Aaci_2787	COG1024	Enoyl-CoA hydratase
Aaci_2788	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
Aaci_2789	COG1984	allophanate hydrolase subunit 2
Aaci_2790	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
Aaci_2791	COG1216	Glycosyl transferase, family 2
Aaci_2791	COG1442	glycosyl transferase family 8
Aaci_2794	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
Aaci_2795	COG1960	acyl-CoA dehydrogenase activity
Aaci_2797	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
Aaci_2804	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
Aaci_2805	COG1803	Methylglyoxal synthase
Aaci_2806	COG0006	proline dipeptidase activity
Aaci_2811	COG2271	Major facilitator Superfamily
Aaci_2812	COG1070	Carbohydrate kinase
Aaci_2815	COG2855	membrane
Aaci_2816	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
Aaci_2817	COG0302	gtp cyclohydrolase
Aaci_2821	COG2124	cytochrome p450
Aaci_2821	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
Aaci_2823	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
Aaci_2824	COG1215	transferase activity, transferring glycosyl groups
Aaci_2827	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
Aaci_2828	COG2318	DinB family
Aaci_2830	COG1609	Transcriptional regulator
Aaci_2831	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
Aaci_2832	COG0813	purine-nucleoside phosphorylase activity
Aaci_2833	COG2171	N-acyltransferase activity
Aaci_2834	COG1473	amidohydrolase
Aaci_2836	COG0436	Aminotransferase
Aaci_2840	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
Aaci_2842	COG4208	sulfate ABC transporter
Aaci_2843	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
Aaci_2844	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
Aaci_2845	COG1116	anion transmembrane transporter activity
Aaci_2846	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Aaci_2847	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
Aaci_2848	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
Aaci_2849	COG0431	NADPH-dependent FMN reductase
Aaci_2851	COG0789	Transcriptional regulator
Aaci_2852	COG1960	acyl-CoA dehydrogenase activity
Aaci_2854	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
Aaci_2856	COG0156	8-amino-7-oxononanoate synthase activity
Aaci_2857	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
Aaci_2859	COG0390	transport system, permease component
Aaci_2860	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
Aaci_2861	COG2130	NADP-dependent
Aaci_2865	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
Aaci_2867	COG3706	GGDEF domain
Aaci_2870	COG1609	Transcriptional regulator
Aaci_2871	COG3833	ABC-type maltose transport systems, permease component
Aaci_2872	COG1175	transmembrane transport
Aaci_2877	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
Aaci_2879	COG0477	Major facilitator Superfamily
Aaci_2884	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
Aaci_2885	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
Aaci_2887	COG1501	Belongs to the glycosyl hydrolase 31 family
Aaci_2888	COG0589	response to stress
Aaci_2889	COG4166	transmembrane transport
Aaci_2891	COG1874	Beta-galactosidase
Aaci_2892	COG0004	ammonium transporteR
Aaci_2893	COG0347	Belongs to the P(II) protein family
Aaci_2897	COG2160	L-arabinose isomerase activity
Aaci_2899	COG1069	ribulokinase activity
Aaci_2900	COG2814	Major facilitator Superfamily
Aaci_2901	COG1609	Transcriptional regulator
Aaci_2903	COG1172	Belongs to the binding-protein-dependent transport system permease family
Aaci_2904	COG1129	ABC transporter
Aaci_2905	COG1609	Transcriptional regulator
Aaci_2909	COG2814	Major facilitator Superfamily
Aaci_2910	COG1566	PFAM secretion protein HlyD family protein
Aaci_2911	COG0484	heat shock protein binding
Aaci_2912	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
Aaci_2915	COG0583	DNA-binding transcription factor activity
Aaci_2917	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Aaci_2918	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
Aaci_2921	COG5002	protein histidine kinase activity
Aaci_2922	COG0745	RESPONSE REGULATOR receiver
Aaci_2924	COG0305	Participates in initiation and elongation during chromosome replication
Aaci_2925	COG0359	binds to the 23S rRNA
Aaci_2928	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
Aaci_2929	COG0629	single-stranded DNA binding
Aaci_2930	COG0360	Binds together with S18 to 16S ribosomal RNA
Aaci_2931	COG0012	GTP binding
Aaci_2933	COG0243	molybdopterin cofactor binding
Aaci_2934	COG4481	Protein conserved in bacteria
Aaci_2935	COG0668	transmembrane transport
Aaci_2939	COG1811	Na channel or pump
Aaci_2940	COG1475	DNA binding
Aaci_2941	COG1192	Involved in chromosome partitioning
Aaci_2942	COG1475	DNA binding
Aaci_2943	COG0357	Ribosomal RNA small subunit methyltransferase G
Aaci_2944	COG0445	tRNA wobble uridine modification
Aaci_2945	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
Aaci_2946	COG1847	R3H domain protein
Aaci_2947	COG0706	membrane insertase activity
Aaci_2948	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
Aaci_2950	COG0230	Belongs to the bacterial ribosomal protein bL34 family
Aaci_2954	COG1396	sequence-specific DNA binding
Aaci_2967	COG0741	lytic transglycosylase activity
Aaci_2968	COG3437	response regulator, receiver
Aaci_2979	COG1192	Involved in chromosome partitioning
Aaci_2989	COG2226	methyltransferase
Aaci_2994	COG1247	-acetyltransferase
Aaci_3004	COG2003	Belongs to the UPF0758 family
Aaci_3009	COG0419	ATPase involved in DNA repair
Aaci_3011	COG0629	single-stranded DNA binding
Aaci_3020	COG1061	Type III restriction enzyme res subunit
Aaci_3023	COG0210	DNA helicase
Aaci_3025	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
Aaci_3032	COG2002	toxin-antitoxin pair type II binding
Aaci_3056	COG4372	Transposase
Aaci_3063	COG1396	sequence-specific DNA binding
Aaci_3065	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
Aaci_3070	COG0697	spore germination
Aaci_3076	COG5001	Diguanylate cyclase
Aaci_3076	COG3300	MHYT domain
Aaci_3092	COG2197	response regulator
Aaci_3118	COG0489	protein tyrosine kinase activity
Aaci_3120	COG4962	Type ii secretion system protein e