locus-tag	class	description
TC41_0003	COG0592	DNA-directed DNA polymerase activity
TC41_0005	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
TC41_0006	COG0187	DNA topoisomerase II activity
TC41_0007	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
TC41_0014	COG0516	GMP reductase activity
TC41_0014	COG0517	IMP dehydrogenase activity
TC41_0015	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
TC41_0016	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
TC41_0022	COG4372	Transposase
TC41_0028	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
TC41_0032	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
TC41_0033	COG2224	Isocitrate lyase
TC41_0045	COG1744	ABC transporter substrate-binding protein PnrA-like
TC41_0048	COG1335	isochorismatase
TC41_0049	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TC41_0050	COG0824	Thioesterase
TC41_0051	COG3842	ATPase activity
TC41_0056	COG0667	Aldo Keto reductase
TC41_0057	COG0656	L-ascorbic acid biosynthetic process
TC41_0058	COG2207	Transcriptional regulator
TC41_0059	COG0745	RESPONSE REGULATOR receiver
TC41_0060	COG5002	protein histidine kinase activity
TC41_0062	COG1279	arginine transmembrane transporter activity
TC41_0066	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
TC41_0068	COG0789	Transcriptional regulator
TC41_0069	COG0747	negative chemotaxis
TC41_0071	COG1392	Phosphate transport regulator
TC41_0072	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
TC41_0073	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
TC41_0075	COG1802	Transcriptional regulator
TC41_0076	COG1028	Short-chain dehydrogenase reductase Sdr
TC41_0081	COG4191	Histidine kinase
TC41_0083	COG1289	transmembrane transporter activity
TC41_0085	COG0194	GDP metabolic process
TC41_0088	COG1028	Short-chain dehydrogenase reductase Sdr
TC41_0089	COG1435	thymidine kinase activity
TC41_0092	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
TC41_0092	COG0644	oxidoreductase
TC41_0093	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
TC41_0094	COG0584	glycerophosphoryl diester phosphodiesterase
TC41_0096	COG0395	ABC-type sugar transport system, permease component
TC41_0097	COG1175	transmembrane transport
TC41_0098	COG2309	aminopeptidase activity
TC41_0100	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
TC41_0101	COG1309	transcriptional regulator
TC41_0102	COG1511	domain protein
TC41_0103	COG3973	AAA domain
TC41_0104	COG0588	phosphoglycerate mutase activity
TC41_0106	COG1940	carbohydrate kinase activity
TC41_0115	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
TC41_0117	COG1850	ribulose-bisphosphate carboxylase activity
TC41_0119	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
TC41_0120	COG0235	Class ii aldolase
TC41_0124	COG0367	asparagine synthase
TC41_0126	COG0590	tRNA wobble adenosine to inosine editing
TC41_0127	COG3852	Histidine kinase
TC41_0129	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
TC41_0130	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
TC41_0131	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
TC41_0132	COG1970	mechanosensitive ion channel activity
TC41_0134	COG0477	Major facilitator Superfamily
TC41_0137	COG0235	Class ii aldolase
TC41_0139	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TC41_0139	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
TC41_0142	COG0840	transmembrane signaling receptor activity
TC41_0143	COG2201	protein-glutamate methylesterase activity
TC41_0145	COG0840	transmembrane signaling receptor activity
TC41_0146	COG2198	Histidine kinase
TC41_0146	COG0643	Histidine kinase
TC41_0147	COG0835	chemotaxis
TC41_0148	COG0840	transmembrane signaling receptor activity
TC41_0150	COG4372	Transposase
TC41_0151	COG4372	Transposase
TC41_0156	COG2244	polysaccharide biosynthetic process
TC41_0159	COG1982	Orn Lys Arg decarboxylase major
TC41_0160	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
TC41_0161	COG3870	Protein conserved in bacteria
TC41_0162	COG0470	DNA polymerase III
TC41_0163	COG1774	PSP1 C-terminal conserved region
TC41_0164	COG4467	Involved in initiation control of chromosome replication
TC41_0166	COG2002	toxin-antitoxin pair type II binding
TC41_0169	COG0084	hydrolase, TatD family'
TC41_0171	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
TC41_0173	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
TC41_0179	COG2197	response regulator
TC41_0182	COG0318	PFAM AMP-dependent synthetase and ligase
TC41_0184	COG1960	acyl-CoA dehydrogenase activity
TC41_0185	COG1024	Enoyl-CoA hydratase
TC41_0186	COG1028	Short-chain dehydrogenase reductase Sdr
TC41_0191	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
TC41_0193	COG1012	belongs to the aldehyde dehydrogenase family
TC41_0194	COG1454	alcohol dehydrogenase
TC41_0200	COG1028	Short-chain dehydrogenase reductase Sdr
TC41_0201	COG1960	acyl-CoA dehydrogenase activity
TC41_0202	COG0318	PFAM AMP-dependent synthetase and ligase
TC41_0203	COG2030	dehydratase
TC41_0220	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
TC41_0224	COG3328	transposase activity
TC41_0237	COG4466	Protein conserved in bacteria
TC41_0241	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
TC41_0242	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
TC41_0243	COG0251	oxidation-reduction process
TC41_0244	COG2088	sporulation resulting in formation of a cellular spore
TC41_0245	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
TC41_0246	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
TC41_0247	COG0193	aminoacyl-tRNA hydrolase activity
TC41_0249	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
TC41_0250	COG3956	TIGRFAM MazG family protein
TC41_0252	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
TC41_0256	COG1098	S1 RNA binding domain
TC41_0259	COG2131	deaminase
TC41_0260	COG2208	phosphoserine phosphatase activity
TC41_0262	COG2304	oxidoreductase activity
TC41_0264	COG0037	tRNA processing
TC41_0266	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
TC41_0269	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
TC41_0270	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
TC41_0271	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
TC41_0272	COG1396	sequence-specific DNA binding
TC41_0279	COG2318	DinB family
TC41_0280	COG1968	undecaprenyl-diphosphatase activity
TC41_0281	COG2223	nitrite transmembrane transporter activity
TC41_0282	COG0697	spore germination
TC41_0284	COG1028	Short-chain dehydrogenase reductase Sdr
TC41_0285	COG0436	Aminotransferase
TC41_0286	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
TC41_0290	COG3711	transcriptional antiterminator
TC41_0292	COG0246	Mannitol dehydrogenase
TC41_0293	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
TC41_0294	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
TC41_0295	COG1595	DNA-templated transcription, initiation
TC41_0305	COG1122	ATPase activity
TC41_0306	COG1122	ATPase activity
TC41_0307	COG1268	BioY protein
TC41_0311	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
TC41_0315	COG1028	Short-chain dehydrogenase reductase Sdr
TC41_0317	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
TC41_0322	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
TC41_0323	COG2814	Major facilitator Superfamily
TC41_0324	COG0583	DNA-binding transcription factor activity
TC41_0327	COG0745	RESPONSE REGULATOR receiver
TC41_0328	COG2205	protein histidine kinase activity
TC41_0329	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
TC41_0330	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
TC41_0331	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
TC41_0332	COG2205	protein histidine kinase activity
TC41_0334	COG0667	Aldo Keto reductase
TC41_0337	COG2814	Major facilitator Superfamily
TC41_0338	COG1388	LysM domain
TC41_0338	COG3858	chitin binding
TC41_0339	COG4213	ABC transporter substrate-binding protein
TC41_0341	COG4214	carbohydrate transport
TC41_0345	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
TC41_0346	COG0386	Belongs to the glutathione peroxidase family
TC41_0356	COG0463	Glycosyl transferase, family 2
TC41_0357	COG1674	ftsk spoiiie
TC41_0361	COG4974	Belongs to the 'phage' integrase family
TC41_0367	COG1674	ftsk spoiiie
TC41_0374	COG4372	Transposase
TC41_0377	COG1566	PFAM secretion protein HlyD family protein
TC41_0378	COG2814	Major facilitator Superfamily
TC41_0385	COG1136	(ABC) transporter
TC41_0386	COG1136	(ABC) transporter
TC41_0386	COG0577	efflux transmembrane transporter activity
TC41_0388	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
TC41_0389	COG0420	3'-5' exonuclease activity
TC41_0390	COG0419	ATPase involved in DNA repair
TC41_0391	COG2814	Major facilitator Superfamily
TC41_0392	COG2217	Heavy metal translocating P-type atpase
TC41_0393	COG0318	PFAM AMP-dependent synthetase and ligase
TC41_0395	COG1595	DNA-templated transcription, initiation
TC41_0397	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
TC41_0398	COG0805	protein transport
TC41_0400	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
TC41_0405	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
TC41_0409	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
TC41_0410	COG1459	type II secretion system
TC41_0426	COG1205	dead DEAH box helicase
TC41_0426	COG1111	helicase
TC41_0428	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
TC41_0429	COG3829	transcription factor binding
TC41_0437	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
TC41_0438	COG1012	belongs to the aldehyde dehydrogenase family
TC41_0439	COG3829	transcription factor binding
TC41_0441	COG0833	amino acid
TC41_0443	COG1132	(ABC) transporter
TC41_0444	COG1132	(ABC) transporter
TC41_0448	COG5263	repeat protein
TC41_0448	COG4193	domain, Protein
TC41_0449	COG1028	Short-chain dehydrogenase reductase Sdr
TC41_0450	COG4977	sequence-specific DNA binding
TC41_0450	COG1917	Cupin 2, conserved barrel domain protein
TC41_0455	COG2814	Major facilitator Superfamily
TC41_0457	COG0179	Fumarylacetoacetate (FAA) hydrolase
TC41_0458	COG1012	belongs to the aldehyde dehydrogenase family
TC41_0462	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
TC41_0464	COG1033	growth of symbiont in host cell
TC41_0464	COG2409	Drug exporters of the RND superfamily
TC41_0466	COG4846	Membrane protein involved in cytochrome C biogenesis
TC41_0468	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
TC41_0471	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
TC41_0473	COG0024	Methionine aminopeptidase
TC41_0479	COG0736	holo-[acyl-carrier-protein] synthase activity
TC41_0480	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
TC41_0480	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
TC41_0481	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
TC41_0482	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
TC41_0484	COG2337	Toxic component of a toxin-antitoxin (TA) module
TC41_0485	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
TC41_0486	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
TC41_0489	COG4844	belongs to the
TC41_0491	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
TC41_0492	COG0802	atpase or kinase
TC41_0494	COG0456	acetyltransferase
TC41_0495	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
TC41_0497	COG0488	(ABC) transporter
TC41_0499	COG0671	phosphoesterase, PA-phosphatase related
TC41_0500	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
TC41_0502	COG1546	Belongs to the CinA family
TC41_0502	COG1058	Belongs to the CinA family
TC41_0503	COG1763	Mo-molybdopterin cofactor biosynthetic process
TC41_0504	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
TC41_0510	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
TC41_0512	COG2197	response regulator
TC41_0514	COG0714	Associated with various cellular activities
TC41_0516	COG1305	Transglutaminase-like
TC41_0517	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TC41_0519	COG0519	Catalyzes the synthesis of GMP from XMP
TC41_0519	COG0518	GMP synthase (glutamine-hydrolyzing) activity
TC41_0520	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
TC41_0521	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
TC41_0522	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
TC41_0524	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
TC41_0525	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
TC41_0526	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
TC41_0527	COG0138	bifunctional purine biosynthesis protein purh
TC41_0528	COG0151	Belongs to the GarS family
TC41_0533	COG2884	Cell division ATP-binding protein ftsE
TC41_0534	COG2177	Part of the ABC transporter FtsEX involved in
TC41_0535	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TC41_0536	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
TC41_0538	COG0556	nucleotide-excision repair
TC41_0539	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
TC41_0540	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
TC41_0544	COG4235	cytochrome complex assembly
TC41_0546	COG1660	Displays ATPase and GTPase activities
TC41_0547	COG0391	Required for morphogenesis under gluconeogenic growth conditions
TC41_0548	COG1481	regulation of sporulation
TC41_0549	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
TC41_0554	COG0670	Belongs to the BI1 family
TC41_0555	COG0495	leucyl-tRNA aminoacylation
TC41_0559	COG0628	permease
TC41_0562	COG1205	dead DEAH box helicase
TC41_0562	COG1111	helicase
TC41_0566	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
TC41_0568	COG0697	spore germination
TC41_0572	COG1012	belongs to the aldehyde dehydrogenase family
TC41_0573	COG1012	belongs to the aldehyde dehydrogenase family
TC41_0576	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TC41_0577	COG0328	RNA-DNA hybrid ribonuclease activity
TC41_0578	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
TC41_0579	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
TC41_0581	COG0538	isocitrate dehydrogenase activity
TC41_0582	COG1414	Transcriptional regulator
TC41_0584	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
TC41_0590	COG2272	Belongs to the type-B carboxylesterase lipase family
TC41_0591	COG2766	serine protein kinase
TC41_0592	COG2718	Belongs to the UPF0229 family
TC41_0593	COG2719	SpoVR family
TC41_0600	COG2860	membrane
TC41_0602	COG2200	EAL domain
TC41_0602	COG2199	diguanylate cyclase activity
TC41_0604	COG0529	Catalyzes the synthesis of activated sulfate
TC41_0607	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
TC41_0608	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
TC41_0610	COG1131	(ABC) transporter
TC41_0612	COG1131	(ABC) transporter
TC41_0613	COG1725	Transcriptional regulator
TC41_0614	COG1234	tRNA 3'-trailer cleavage
TC41_0615	COG2814	Major facilitator Superfamily
TC41_0616	COG1846	Transcriptional regulator
TC41_0619	COG1131	(ABC) transporter
TC41_0620	COG0842	Transport permease protein
TC41_0622	COG4585	Histidine kinase
TC41_0623	COG2197	response regulator
TC41_0626	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
TC41_0628	COG1845	cytochrome c oxidase, subunit III
TC41_0629	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
TC41_0630	COG1612	heme a metabolic process
TC41_0631	COG1686	Belongs to the peptidase S11 family
TC41_0635	COG0667	Aldo Keto reductase
TC41_0636	COG1454	alcohol dehydrogenase
TC41_0637	COG1028	Short-chain dehydrogenase reductase Sdr
TC41_0641	COG0745	RESPONSE REGULATOR receiver
TC41_0642	COG5002	protein histidine kinase activity
TC41_0644	COG1028	Short-chain dehydrogenase reductase Sdr
TC41_0647	COG1028	Short-chain dehydrogenase reductase Sdr
TC41_0648	COG3384	dioxygenase
TC41_0649	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
TC41_0650	COG0454	-acetyltransferase
TC41_0651	COG0210	DNA helicase
TC41_0652	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
TC41_0655	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TC41_0656	COG0154	amidase activity
TC41_0657	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TC41_0658	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
TC41_0659	COG1073	alpha beta
TC41_0670	COG3263	regulation of cellular component size
TC41_0672	COG1070	Carbohydrate kinase
TC41_0673	COG3347	Dehydrogenase
TC41_0673	COG1028	Short-chain dehydrogenase reductase Sdr
TC41_0677	COG1069	ribulokinase activity
TC41_0678	COG1129	ABC transporter
TC41_0679	COG1172	Belongs to the binding-protein-dependent transport system permease family
TC41_0682	COG1070	Carbohydrate kinase
TC41_0684	COG1349	DNA-binding transcription factor activity
TC41_0687	COG0247	lactate metabolic process
TC41_0689	COG2323	membrane
TC41_0692	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
TC41_0694	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
TC41_0694	COG2755	lipolytic protein G-D-S-L family
TC41_0700	COG0318	PFAM AMP-dependent synthetase and ligase
TC41_0701	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
TC41_0702	COG2271	Major facilitator Superfamily
TC41_0703	COG2155	Conserved Protein
TC41_0704	COG0019	diaminopimelate decarboxylase activity
TC41_0707	COG1914	H( )-stimulated, divalent metal cation uptake system
TC41_0710	COG1164	Oligoendopeptidase f
TC41_0711	COG5002	protein histidine kinase activity
TC41_0713	COG0126	phosphoglycerate kinase activity
TC41_0714	COG0149	triose-phosphate isomerase activity
TC41_0716	COG0148	phosphopyruvate hydratase activity
TC41_0717	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
TC41_0718	COG2807	transmembrane transport
TC41_0719	COG0557	exoribonuclease II activity
TC41_0720	COG0557	exoribonuclease II activity
TC41_0721	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
TC41_0723	COG1012	belongs to the aldehyde dehydrogenase family
TC41_0724	COG5609	conserved protein (DUF2294)
TC41_0726	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
TC41_0728	COG3002	Belongs to the UPF0753 family
TC41_0729	COG3002	Belongs to the UPF0753 family
TC41_0730	COG3002	Belongs to the UPF0753 family
TC41_0736	COG2226	methyltransferase
TC41_0739	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
TC41_0740	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
TC41_0743	COG3665	Urea carboxylase-associated protein
TC41_0744	COG0439	Biotin carboxylase
TC41_0747	COG0395	ABC-type sugar transport system, permease component
TC41_0748	COG1175	transmembrane transport
TC41_0757	COG0681	Belongs to the peptidase S26 family
TC41_0758	COG0667	Aldo Keto reductase
TC41_0759	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
TC41_0765	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
TC41_0767	COG0673	inositol 2-dehydrogenase activity
TC41_0768	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
TC41_0771	COG3459	Glycosyltransferase 36 associated
TC41_0772	COG2814	Major facilitator Superfamily
TC41_0774	COG2079	MmgE PrpD family protein
TC41_0775	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
TC41_0776	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
TC41_0779	COG0542	response to heat
TC41_0781	COG0163	prenyltransferase activity
TC41_0784	COG0477	Major facilitator Superfamily
TC41_0786	COG1454	alcohol dehydrogenase
TC41_0787	COG0318	PFAM AMP-dependent synthetase and ligase
TC41_0789	COG1606	tRNA processing
TC41_0790	COG1606	tRNA processing
TC41_0791	COG1691	(AIR) carboxylase
TC41_0793	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
TC41_0798	COG1546	Belongs to the CinA family
TC41_0798	COG1058	Belongs to the CinA family
TC41_0799	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
TC41_0801	COG4569	acetaldehyde dehydrogenase (acetylating) activity
TC41_0803	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
TC41_0804	COG1309	transcriptional regulator
TC41_0805	COG3396	Phenylacetate-CoA oxygenase
TC41_0808	COG2151	metal-sulfur cluster biosynthetic enzyme
TC41_0809	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
TC41_0812	COG1012	belongs to the aldehyde dehydrogenase family
TC41_0813	COG1024	Enoyl-CoA hydratase
TC41_0815	COG1322	Protein conserved in bacteria
TC41_0817	COG1346	cytolysis
TC41_0819	COG1380	Effector of murein hydrolase LrgA
TC41_0820	COG0583	DNA-binding transcription factor activity
TC41_0822	COG2808	Putative FMN-binding domain
TC41_0823	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
TC41_0827	COG1024	Enoyl-CoA hydratase
TC41_0828	COG2962	Rard protein
TC41_0833	COG1132	(ABC) transporter
TC41_0834	COG1132	(ABC) transporter
TC41_0835	COG1132	(ABC) transporter
TC41_0836	COG0604	alcohol dehydrogenase
TC41_0839	COG1132	(ABC) transporter
TC41_0842	COG5609	conserved protein (DUF2294)
TC41_0843	COG2116	formate transmembrane transporter activity
TC41_0844	COG3383	formate dehydrogenase (NAD+) activity
TC41_0847	COG1252	NADH dehydrogenase
TC41_0849	COG0656	L-ascorbic acid biosynthetic process
TC41_0854	COG3069	C4-dicarboxylate transmembrane transporter activity
TC41_0855	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
TC41_0856	COG2814	Major facilitator Superfamily
TC41_0862	COG0561	phosphatase activity
TC41_0866	COG0519	Catalyzes the synthesis of GMP from XMP
TC41_0868	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
TC41_0869	COG1119	ATPase activity
TC41_0870	COG2353	YceI-like domain
TC41_0871	COG1733	regulation of RNA biosynthetic process
TC41_0873	COG2046	Belongs to the sulfate adenylyltransferase family
TC41_0874	COG3361	conserved protein (COG2071)
TC41_0875	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
TC41_0876	COG1012	belongs to the aldehyde dehydrogenase family
TC41_0877	COG0667	Aldo Keto reductase
TC41_0878	COG0220	tRNA (guanine-N7-)-methyltransferase activity
TC41_0879	COG1335	isochorismatase
TC41_0882	COG2814	Major facilitator Superfamily
TC41_0883	COG3973	AAA domain
TC41_0884	COG2207	Transcriptional regulator
TC41_0885	COG0477	Major facilitator Superfamily
TC41_0886	COG2153	protein acetylation
TC41_0888	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
TC41_0890	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
TC41_0893	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
TC41_0897	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
TC41_0897	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
TC41_0897	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
TC41_0899	COG1349	DNA-binding transcription factor activity
TC41_0900	COG1105	Belongs to the carbohydrate kinase PfkB family
TC41_0903	COG0154	amidase activity
TC41_0906	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
TC41_0907	COG0640	Transcriptional regulator
TC41_0910	COG0626	cystathionine gamma-synthase activity
TC41_0914	COG0318	PFAM AMP-dependent synthetase and ligase
TC41_0917	COG0424	maF-like protein
TC41_0918	COG2081	HI0933 family
TC41_0920	COG1979	alcohol dehydrogenase
TC41_0924	COG1175	transmembrane transport
TC41_0925	COG0395	ABC-type sugar transport system, permease component
TC41_0926	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
TC41_0927	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
TC41_0931	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
TC41_0932	COG2823	Periplasmic or secreted lipoprotein
TC41_0932	COG1652	LysM domain
TC41_0933	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
TC41_0934	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
TC41_0936	COG0131	Imidazoleglycerol-phosphate dehydratase
TC41_0937	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
TC41_0938	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
TC41_0939	COG0107	imidazoleglycerol-phosphate synthase activity
TC41_0940	COG0140	phosphoribosyl-ATP diphosphatase activity
TC41_0940	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
TC41_0944	COG0604	alcohol dehydrogenase
TC41_0946	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TC41_0946	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TC41_0948	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
TC41_0948	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
TC41_0949	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
TC41_0951	COG4721	ABC-type cobalt transport system, permease component
TC41_0952	COG1122	ATPase activity
TC41_0956	COG0583	DNA-binding transcription factor activity
TC41_0957	COG0482	sulfurtransferase activity
TC41_0961	COG4221	oxidoreductase activity
TC41_0965	COG1960	acyl-CoA dehydrogenase activity
TC41_0967	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
TC41_0973	COG0564	pseudouridine synthase activity
TC41_0974	COG1295	ribonuclease BN
TC41_0975	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
TC41_0978	COG1160	GTP binding
TC41_0979	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
TC41_0980	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TC41_0981	COG1191	sigma factor activity
TC41_0982	COG0586	Pfam SNARE associated Golgi protein
TC41_0985	COG1191	sigma factor activity
TC41_0988	COG0302	gtp cyclohydrolase
TC41_0989	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
TC41_0992	COG0167	dihydroorotate dehydrogenase activity
TC41_0996	COG0686	Belongs to the AlaDH PNT family
TC41_0997	COG2151	metal-sulfur cluster biosynthetic enzyme
TC41_0998	COG0396	ATPase activity
TC41_1000	COG0719	Fe-S assembly protein
TC41_1001	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
TC41_1002	COG0822	iron-sulfur transferase activity
TC41_1003	COG0719	Fe-S assembly protein
TC41_1005	COG1959	2 iron, 2 sulfur cluster binding
TC41_1010	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
TC41_1011	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
TC41_1015	COG0531	amino acid
TC41_1020	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
TC41_1025	COG0587	DNA-directed DNA polymerase activity
TC41_1027	COG0671	phosphoesterase, PA-phosphatase related
TC41_1030	COG0537	adenosine 5'-monophosphoramidase activity
TC41_1033	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
TC41_1035	COG0612	Peptidase, M16
TC41_1036	COG0612	Peptidase, M16
TC41_1038	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
TC41_1039	COG0083	homoserine kinase activity
TC41_1040	COG2050	protein possibly involved in aromatic compounds catabolism
TC41_1048	COG4372	Transposase
TC41_1065	COG0772	Belongs to the SEDS family
TC41_1067	COG0584	glycerophosphoryl diester phosphodiesterase
TC41_1068	COG0772	Belongs to the SEDS family
TC41_1069	COG0436	Aminotransferase
TC41_1074	COG1982	Orn Lys Arg decarboxylase major
TC41_1076	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
TC41_1078	COG0316	Belongs to the HesB IscA family
TC41_1079	COG1078	dGTPase activity
TC41_1080	COG0586	Pfam SNARE associated Golgi protein
TC41_1081	COG3377	Domain of unknown function (DUF1805)
TC41_1082	COG1363	Peptidase, m42
TC41_1083	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
TC41_1084	COG0494	nUDIX hydrolase
TC41_1086	COG1388	LysM domain
TC41_1086	COG3584	3D domain protein
TC41_1093	COG1012	belongs to the aldehyde dehydrogenase family
TC41_1096	COG2070	2-Nitropropane dioxygenase
TC41_1097	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
TC41_1098	COG0582	viral genome integration into host DNA
TC41_1100	COG2801	Transposase and inactivated derivatives
TC41_1104	COG3328	transposase activity
TC41_1108	COG0395	ABC-type sugar transport system, permease component
TC41_1110	COG3250	beta-galactosidase activity
TC41_1114	COG4372	Transposase
TC41_1118	COG1960	acyl-CoA dehydrogenase activity
TC41_1119	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
TC41_1120	COG1028	Short-chain dehydrogenase reductase Sdr
TC41_1122	COG0318	PFAM AMP-dependent synthetase and ligase
TC41_1124	COG1609	Transcriptional regulator
TC41_1127	COG0512	Glutamine amidotransferase of anthranilate synthase
TC41_1130	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
TC41_1132	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
TC41_1133	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
TC41_1135	COG0067	glutamate synthase
TC41_1135	COG0070	glutamate synthase
TC41_1135	COG0069	glutamate synthase activity
TC41_1137	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
TC41_1138	COG0137	argininosuccinate synthase activity
TC41_1139	COG0165	Argininosuccinate lyase
TC41_1144	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
TC41_1145	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
TC41_1152	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
TC41_1162	COG1725	Transcriptional regulator
TC41_1164	COG1131	(ABC) transporter
TC41_1168	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
TC41_1174	COG0655	NAD(P)H dehydrogenase (quinone) activity
TC41_1175	COG1802	Transcriptional regulator
TC41_1176	COG1584	GPR1 FUN34 yaaH family protein
TC41_1177	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TC41_1178	COG3906	Belongs to the UPF0473 family
TC41_1183	COG0740	serine-type endopeptidase activity
TC41_1184	COG1104	cysteine desulfurase activity
TC41_1185	COG0301	tRNA thio-modification
TC41_1190	COG0300	oxidoreductase activity
TC41_1191	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
TC41_1192	COG2001	Belongs to the MraZ family
TC41_1193	COG0275	rRNA processing
TC41_1196	COG0768	penicillin binding
TC41_1197	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
TC41_1198	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
TC41_1199	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
TC41_1200	COG0772	Belongs to the SEDS family
TC41_1201	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
TC41_1202	COG0812	UDP-N-acetylmuramate dehydrogenase activity
TC41_1203	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
TC41_1204	COG0492	ferredoxin-NADP+ reductase activity
TC41_1206	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
TC41_1207	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
TC41_1211	COG3856	small basic protein
TC41_1212	COG0849	cell division
TC41_1213	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
TC41_1214	COG3328	transposase activity
TC41_1218	COG1191	sigma factor activity
TC41_1219	COG1191	sigma factor activity
TC41_1220	COG1873	PFAM PRC-barrel domain
TC41_1222	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
TC41_1225	COG3599	regulation of cell shape
TC41_1228	COG1809	phosphosulfolactate synthase activity
TC41_1229	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
TC41_1230	COG0564	pseudouridine synthase activity
TC41_1232	COG0540	Belongs to the ATCase OTCase family
TC41_1233	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
TC41_1236	COG0284	orotidine-5'-phosphate decarboxylase activity
TC41_1237	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
TC41_1238	COG0723	plastoquinol--plastocyanin reductase activity
TC41_1238	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TC41_1240	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
TC41_1243	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
TC41_1244	COG1561	YicC-like family, N-terminal region
TC41_1246	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
TC41_1247	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
TC41_1248	COG0242	peptide deformylase activity
TC41_1249	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
TC41_1250	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
TC41_1250	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
TC41_1251	COG0820	rRNA (adenine-C2-)-methyltransferase activity
TC41_1252	COG0631	protein serine/threonine phosphatase activity
TC41_1253	COG0515	serine threonine protein kinase
TC41_1253	COG2815	serine threonine protein kinase
TC41_1255	COG1162	GTPase activity
TC41_1257	COG0227	Belongs to the bacterial ribosomal protein bL28 family
TC41_1258	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
TC41_1260	COG0688	phosphatidylethanolamine metabolic process
TC41_1263	COG0154	amidase activity
TC41_1264	COG0742	ribosomal rna small subunit methyltransferase
TC41_1265	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
TC41_1266	COG1752	Esterase of the alpha-beta hydrolase superfamily
TC41_1268	COG0333	Belongs to the bacterial ribosomal protein bL32 family
TC41_1270	COG0416	fatty acid biosynthetic process
TC41_1271	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
TC41_1272	COG1028	Short-chain dehydrogenase reductase Sdr
TC41_1273	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
TC41_1274	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
TC41_1275	COG0571	ribonuclease III activity
TC41_1276	COG1196	nuclear chromosome segregation
TC41_1277	COG0552	protein localization to endoplasmic reticulum
TC41_1278	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
TC41_1279	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
TC41_1280	COG0228	four-way junction DNA binding
TC41_1281	COG1837	Belongs to the UPF0109 family
TC41_1284	COG0336	Belongs to the RNA methyltransferase TrmD family
TC41_1287	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
TC41_1288	COG0564	pseudouridine synthase activity
TC41_1290	COG0739	heme binding
TC41_1291	COG1607	acyl-coa hydrolase
TC41_1297	COG0335	large ribosomal subunit rRNA binding
TC41_1299	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
TC41_1302	COG0726	polysaccharide deacetylase
TC41_1305	COG0045	succinate-CoA ligase (ADP-forming) activity
TC41_1307	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
TC41_1308	COG0758	DNA mediated transformation
TC41_1308	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
TC41_1311	COG1388	LysM domain
TC41_1311	COG0791	NLP P60 protein
TC41_1311	COG3103	Sh3 type 3 domain protein
TC41_1314	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
TC41_1315	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
TC41_1317	COG4974	Belongs to the 'phage' integrase family
TC41_1318	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
TC41_1324	COG1677	Flagellar hook-basal body complex protein FliE
TC41_1325	COG1766	The M ring may be actively involved in energy transduction
TC41_1326	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
TC41_1328	COG1157	protein secretion by the type III secretion system
TC41_1336	COG1749	Flagellar hook protein flgE
TC41_1339	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
TC41_1340	COG1776	CheC inhibitor of MCP methylation
TC41_1340	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
TC41_1341	COG2201	protein-glutamate methylesterase activity
TC41_1342	COG3190	flagellar
TC41_1343	COG1338	Plays a role in the flagellum-specific transport system
TC41_1344	COG1987	bacterial-type flagellum assembly
TC41_1346	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
TC41_1347	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
TC41_1348	COG1419	protein localization to endoplasmic reticulum
TC41_1349	COG2894	cell division
TC41_1351	COG2198	Histidine kinase
TC41_1351	COG0643	Histidine kinase
TC41_1352	COG0835	chemotaxis
TC41_1353	COG1776	CheC inhibitor of MCP methylation
TC41_1354	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
TC41_1358	COG0052	Belongs to the universal ribosomal protein uS2 family
TC41_1360	COG0528	UMP kinase activity
TC41_1361	COG0233	cytoplasmic translational termination
TC41_1362	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
TC41_1363	COG4589	Belongs to the CDS family
TC41_1364	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
TC41_1365	COG0750	zinc metalloprotease
TC41_1366	COG2176	DNA-directed DNA polymerase activity
TC41_1367	COG0346	lactoylglutathione lyase activity
TC41_1368	COG0077	Prephenate dehydratase
TC41_1370	COG0779	Required for maturation of 30S ribosomal subunits
TC41_1371	COG0195	Participates in both transcription termination and antitermination
TC41_1372	COG2740	Nucleic-acid-binding protein implicated in transcription termination
TC41_1374	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
TC41_1375	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
TC41_1376	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
TC41_1377	COG0196	riboflavin kinase activity
TC41_1379	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
TC41_1380	COG1185	polyribonucleotide nucleotidyltransferase activity
TC41_1381	COG0726	polysaccharide deacetylase
TC41_1382	COG0612	Peptidase, M16
TC41_1384	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
TC41_1385	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
TC41_1386	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
TC41_1387	COG0527	aspartate kinase activity
TC41_1391	COG1960	acyl-CoA dehydrogenase activity
TC41_1393	COG1012	belongs to the aldehyde dehydrogenase family
TC41_1394	COG1024	Enoyl-CoA hydratase
TC41_1395	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TC41_1396	COG0183	Belongs to the thiolase family
TC41_1400	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
TC41_1401	COG0740	serine-type endopeptidase activity
TC41_1403	COG1674	ftsk spoiiie
TC41_1403	COG4980	gas vesicle protein
TC41_1408	COG1426	Protein conserved in bacteria
TC41_1409	COG1666	GTP binding
TC41_1410	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
TC41_1411	COG1058	Belongs to the CinA family
TC41_1411	COG1546	Belongs to the CinA family
TC41_1412	COG0513	Belongs to the DEAD box helicase family
TC41_1413	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
TC41_1415	COG1418	mRNA catabolic process
TC41_1416	COG2359	stage V sporulation protein S
TC41_1423	COG0189	ligase activity
TC41_1425	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TC41_1427	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
TC41_1428	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
TC41_1429	COG2136	Putative SAM-dependent methyltransferase
TC41_1429	COG2521	methyltransferase
TC41_1430	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
TC41_1431	COG1923	regulation of RNA biosynthetic process
TC41_1442	COG2801	Transposase and inactivated derivatives
TC41_1447	COG0473	3-isopropylmalate dehydrogenase activity
TC41_1449	COG0697	spore germination
TC41_1453	COG0697	spore germination
TC41_1454	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
TC41_1455	COG2244	polysaccharide biosynthetic process
TC41_1458	COG0464	growth
TC41_1462	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
TC41_1463	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
TC41_1464	COG0789	Transcriptional regulator
TC41_1465	COG0174	glutamine synthetase
TC41_1468	COG2721	sulfolactate sulfo-lyase activity
TC41_1469	COG3718	enzyme involved in inositol metabolism
TC41_1470	COG0246	Mannitol dehydrogenase
TC41_1471	COG2814	Major facilitator Superfamily
TC41_1472	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
TC41_1473	COG0561	phosphatase activity
TC41_1474	COG0423	glycine-tRNA ligase activity
TC41_1476	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
TC41_1476	COG0646	methionine synthase
TC41_1479	COG3706	GGDEF domain
TC41_1484	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
TC41_1485	COG2086	electron transfer activity
TC41_1486	COG1309	transcriptional regulator
TC41_1487	COG2181	nitrate reductase activity
TC41_1487	COG0247	lactate metabolic process
TC41_1488	COG1250	3-hydroxyacyl-CoA dehydrogenase
TC41_1488	COG1024	Enoyl-CoA hydratase
TC41_1489	COG0183	Belongs to the thiolase family
TC41_1490	COG1960	acyl-CoA dehydrogenase activity
TC41_1491	COG0318	PFAM AMP-dependent synthetase and ligase
TC41_1493	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
TC41_1494	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
TC41_1495	COG0531	amino acid
TC41_1496	COG1289	transmembrane transporter activity
TC41_1500	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
TC41_1501	COG0517	IMP dehydrogenase activity
TC41_1501	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
TC41_1503	COG0574	Belongs to the PEP-utilizing enzyme family
TC41_1503	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
TC41_1504	COG1494	fructose-1,6-bisphosphatase
TC41_1507	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
TC41_1513	COG1942	4-Oxalocrotonate Tautomerase
TC41_1520	COG1414	Transcriptional regulator
TC41_1523	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
TC41_1524	COG0174	glutamine synthetase
TC41_1525	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
TC41_1526	COG0445	tRNA wobble uridine modification
TC41_1528	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TC41_1531	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
TC41_1532	COG1181	Belongs to the D-alanine--D-alanine ligase family
TC41_1533	COG3935	DnaD domain protein
TC41_1534	COG0017	Asparaginyl-tRNA synthetase
TC41_1535	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
TC41_1539	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
TC41_1541	COG0402	S-adenosylhomocysteine deaminase activity
TC41_1542	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
TC41_1543	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
TC41_1546	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
TC41_1547	COG1199	ATP-dependent helicase activity
TC41_1547	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
TC41_1550	COG0617	tRNA 3'-terminal CCA addition
TC41_1551	COG0438	transferase activity, transferring glycosyl groups
TC41_1552	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
TC41_1553	COG1694	Mazg nucleotide pyrophosphohydrolase
TC41_1555	COG3314	Sporulation integral membrane protein YlbJ
TC41_1556	COG1968	undecaprenyl-diphosphatase activity
TC41_1557	COG3949	Membrane
TC41_1558	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
TC41_1561	COG0287	Prephenate dehydrogenase
TC41_1562	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
TC41_1563	COG0159	tryptophan synthase activity
TC41_1564	COG0133	tryptophan synthase activity
TC41_1566	COG0134	indole-3-glycerol-phosphate synthase activity
TC41_1567	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
TC41_1568	COG4401	Chorismate mutase type I
TC41_1569	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
TC41_1570	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
TC41_1573	COG1363	Peptidase, m42
TC41_1576	COG1388	LysM domain
TC41_1576	COG0791	NLP P60 protein
TC41_1578	COG0714	Associated with various cellular activities
TC41_1581	COG0508	dehydrogenase complex catalyzes the overall conversion of
TC41_1582	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
TC41_1583	COG0517	IMP dehydrogenase activity
TC41_1585	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
TC41_1587	COG0105	UTP biosynthetic process
TC41_1588	COG0142	geranyltranstransferase activity
TC41_1589	COG2226	methyltransferase
TC41_1592	COG1064	alcohol dehydrogenase
TC41_1593	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
TC41_1596	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
TC41_1598	COG1160	GTP binding
TC41_1600	COG0539	negative regulation of cytoplasmic translation
TC41_1603	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
TC41_1605	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
TC41_1607	COG3409	Peptidoglycan-binding domain 1 protein
TC41_1607	COG3773	Cell wall hydrolase
TC41_1609	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
TC41_1610	COG4862	establishment of competence for transformation
TC41_1611	COG1609	Transcriptional regulator
TC41_1615	COG0210	DNA helicase
TC41_1615	COG0210	DNA helicase
TC41_1619	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TC41_1622	COG2339	peptidase activity
TC41_1624	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
TC41_1626	COG5002	protein histidine kinase activity
TC41_1627	COG0745	RESPONSE REGULATOR receiver
TC41_1629	COG1187	pseudouridine synthase activity
TC41_1630	COG0700	Nucleoside recognition
TC41_1631	COG2715	membrane protein required for spore maturation
TC41_1632	COG3874	Sporulation protein YtfJ
TC41_1634	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
TC41_1635	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
TC41_1636	COG1994	Peptidase M50
TC41_1641	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
TC41_1643	COG1191	sigma factor activity
TC41_1645	COG1366	Belongs to the anti-sigma-factor antagonist family
TC41_1647	COG1686	Belongs to the peptidase S11 family
TC41_1648	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
TC41_1649	COG4974	Belongs to the 'phage' integrase family
TC41_1652	COG1379	DNA repair
TC41_1653	COG0494	nUDIX hydrolase
TC41_1654	COG2195	Cleaves the N-terminal amino acid of tripeptides
TC41_1655	COG0321	lipoyl(octanoyl) transferase activity
TC41_1656	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
TC41_1657	COG0315	cyclic pyranopterin monophosphate synthase activity
TC41_1659	COG3858	chitin binding
TC41_1659	COG1388	LysM domain
TC41_1668	COG0750	zinc metalloprotease
TC41_1669	COG0497	DNA recombination
TC41_1670	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
TC41_1672	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
TC41_1676	COG1570	exodeoxyribonuclease VII activity
TC41_1677	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
TC41_1678	COG0492	ferredoxin-NADP+ reductase activity
TC41_1680	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
TC41_1684	COG1302	Protein conserved in bacteria
TC41_1685	COG0439	Biotin carboxylase
TC41_1687	COG0511	ligase activity, forming carbon-carbon bonds
TC41_1695	COG3854	ATPases associated with a variety of cellular activities
TC41_1696	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
TC41_1697	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
TC41_1698	COG0406	alpha-ribazole phosphatase activity
TC41_1699	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
TC41_1700	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
TC41_1701	COG0404	The glycine cleavage system catalyzes the degradation of glycine
TC41_1702	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
TC41_1704	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
TC41_1705	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
TC41_1707	COG2002	toxin-antitoxin pair type II binding
TC41_1720	COG1192	Involved in chromosome partitioning
TC41_1722	COG2200	EAL domain
TC41_1741	COG3437	response regulator, receiver
TC41_1749	COG1988	membrane-bound metal-dependent
TC41_1750	COG3617	BRO family, N-terminal domain
TC41_1769	COG1475	DNA binding
TC41_1778	COG1475	DNA binding
TC41_1788	COG0338	D12 class N6 adenine-specific DNA methyltransferase
TC41_1797	COG4372	Transposase
TC41_1798	COG0640	Transcriptional regulator
TC41_1801	COG0346	lactoylglutathione lyase activity
TC41_1807	COG2801	Transposase and inactivated derivatives
TC41_1808	COG1028	Short-chain dehydrogenase reductase Sdr
TC41_1810	COG0531	amino acid
TC41_1816	COG4372	Transposase
TC41_1818	COG4372	Transposase
TC41_1828	COG0179	Fumarylacetoacetate (FAA) hydrolase
TC41_1832	COG0318	PFAM AMP-dependent synthetase and ligase
TC41_1833	COG0183	Belongs to the thiolase family
TC41_1834	COG1024	Enoyl-CoA hydratase
TC41_1835	COG1250	3-hydroxyacyl-CoA dehydrogenase
TC41_1837	COG2801	Transposase and inactivated derivatives
TC41_1843	COG4372	Transposase
TC41_1850	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
TC41_1866	COG0592	DNA-directed DNA polymerase activity
TC41_1889	COG1396	sequence-specific DNA binding
TC41_1893	COG1396	sequence-specific DNA binding
TC41_1895	COG1396	sequence-specific DNA binding
TC41_1897	COG0582	viral genome integration into host DNA
TC41_1898	COG3328	transposase activity
TC41_1905	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
TC41_1908	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
TC41_1910	COG0211	Belongs to the bacterial ribosomal protein bL27 family
TC41_1911	COG2868	ribosomal protein
TC41_1913	COG1994	Peptidase M50
TC41_1915	COG2894	cell division
TC41_1916	COG0850	regulation of cytokinetic process
TC41_1919	COG1077	Cell shape determining protein MreB Mrl
TC41_1920	COG2003	Belongs to the UPF0758 family
TC41_1924	COG3583	domain protein
TC41_1924	COG3584	3D domain protein
TC41_1925	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
TC41_1926	COG0285	dihydrofolate synthase activity
TC41_1927	COG0525	valine-tRNA ligase activity
TC41_1932	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
TC41_1934	COG0113	porphobilinogen synthase activity
TC41_1936	COG0181	hydroxymethylbilane synthase activity
TC41_1938	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
TC41_1939	COG0218	Necessary for normal cell division and for the maintenance of normal septation
TC41_1940	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
TC41_1941	COG1067	ATP-dependent peptidase activity
TC41_1941	COG0470	DNA polymerase III
TC41_1942	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
TC41_1943	COG0740	serine-type endopeptidase activity
TC41_1944	COG0544	peptidyl-prolyl cis-trans isomerase activity
TC41_1945	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
TC41_1946	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
TC41_1947	COG1846	Transcriptional regulator
TC41_1948	COG1960	acyl-CoA dehydrogenase activity
TC41_1949	COG1804	L-carnitine dehydratase bile acid-inducible protein F
TC41_1952	COG2197	response regulator
TC41_1953	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
TC41_1955	COG2188	Transcriptional regulator
TC41_1959	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
TC41_1960	COG1053	succinate dehydrogenase
TC41_1961	COG2009	succinate dehydrogenase
TC41_1962	COG0322	excinuclease ABC activity
TC41_1964	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
TC41_1966	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
TC41_1968	COG0387	Pfam Sodium calcium exchanger
TC41_1974	COG0463	Glycosyl transferase, family 2
TC41_1976	COG1846	Transcriptional regulator
TC41_1980	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
TC41_1981	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
TC41_1986	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
TC41_1987	COG0647	UMP catabolic process
TC41_1988	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TC41_1991	COG2076	Multidrug Resistance protein
TC41_1992	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
TC41_1996	COG4608	Belongs to the ABC transporter superfamily
TC41_1999	COG0601	transmembrane transport
TC41_2003	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
TC41_2004	COG0704	Plays a role in the regulation of phosphate uptake
TC41_2006	COG1388	LysM domain
TC41_2006	COG0791	NLP P60 protein
TC41_2007	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
TC41_2008	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
TC41_2010	COG0726	polysaccharide deacetylase
TC41_2011	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
TC41_2017	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
TC41_2020	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
TC41_2021	COG1575	Belongs to the MenA family. Type 1 subfamily
TC41_2022	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
TC41_2023	COG2427	Protein of unknown function (DUF1641)
TC41_2024	COG3383	formate dehydrogenase (NAD+) activity
TC41_2025	COG1331	Highly conserved protein containing a thioredoxin domain
TC41_2026	COG1331	Highly conserved protein containing a thioredoxin domain
TC41_2029	COG0697	spore germination
TC41_2031	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
TC41_2032	COG0351	phosphomethylpyrimidine kinase
TC41_2033	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
TC41_2034	COG0352	thiamine-phosphate diphosphorylase activity
TC41_2038	COG0697	spore germination
TC41_2039	COG0069	glutamate synthase activity
TC41_2041	COG4988	ABC transporter
TC41_2042	COG1294	oxidase, subunit
TC41_2043	COG1271	oxidase subunit
TC41_2044	COG0477	Major facilitator Superfamily
TC41_2046	COG1846	Transcriptional regulator
TC41_2048	COG1120	ATPase activity
TC41_2049	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TC41_2050	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
TC41_2056	COG1733	regulation of RNA biosynthetic process
TC41_2057	COG0720	synthase
TC41_2058	COG0602	queuosine metabolic process
TC41_2061	COG0248	Ppx GppA phosphatase
TC41_2062	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
TC41_2066	COG0306	phosphate transporter
TC41_2067	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
TC41_2071	COG0697	spore germination
TC41_2075	COG4191	Histidine kinase
TC41_2077	COG1902	pentaerythritol trinitrate reductase activity
TC41_2078	COG5002	protein histidine kinase activity
TC41_2079	COG0745	RESPONSE REGULATOR receiver
TC41_2084	COG0010	Belongs to the arginase family
TC41_2085	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
TC41_2086	COG2384	SAM-dependent methyltransferase
TC41_2088	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
TC41_2089	COG0358	DNA primase activity
TC41_2091	COG1381	Involved in DNA repair and RecF pathway recombination
TC41_2093	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
TC41_2095	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
TC41_2096	COG1480	7TM receptor with intracellular HD hydrolase
TC41_2097	COG1702	phosphate starvation-inducible protein PhoH
TC41_2100	COG1610	YqeY-like protein
TC41_2101	COG0828	Belongs to the bacterial ribosomal protein bS21 family
TC41_2103	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
TC41_2104	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TC41_2105	COG1385	rRNA (uridine-N3-)-methyltransferase activity
TC41_2106	COG2264	protein methyltransferase activity
TC41_2107	COG0484	heat shock protein binding
TC41_2109	COG0443	Heat shock 70 kDa protein
TC41_2110	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
TC41_2111	COG1420	regulation of RNA biosynthetic process
TC41_2113	COG0635	Involved in the biosynthesis of porphyrin-containing compound
TC41_2115	COG0481	GTPase activity
TC41_2118	COG0741	lytic transglycosylase activity
TC41_2120	COG0268	Binds directly to 16S ribosomal RNA
TC41_2123	COG1252	NADH dehydrogenase
TC41_2125	COG1596	polysaccharide export
TC41_2125	COG1555	photosystem II stabilization
TC41_2127	COG1321	iron dependent repressor
TC41_2128	COG2226	methyltransferase
TC41_2129	COG0799	negative regulation of ribosome biogenesis
TC41_2130	COG1713	HD superfamily hydrolase involved in NAD metabolism
TC41_2131	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
TC41_2132	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
TC41_2135	COG1191	sigma factor activity
TC41_2139	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
TC41_2141	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
TC41_2142	COG0628	permease
TC41_2144	COG1104	cysteine desulfurase activity
TC41_2145	COG1959	2 iron, 2 sulfur cluster binding
TC41_2150	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
TC41_2151	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
TC41_2155	COG0318	PFAM AMP-dependent synthetase and ligase
TC41_2156	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
TC41_2157	COG0124	histidyl-tRNA synthetase
TC41_2159	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
TC41_2163	COG1131	(ABC) transporter
TC41_2165	COG2814	Major facilitator Superfamily
TC41_2167	COG1175	transmembrane transport
TC41_2171	COG1024	Enoyl-CoA hydratase
TC41_2172	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
TC41_2173	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
TC41_2174	COG0511	ligase activity, forming carbon-carbon bonds
TC41_2175	COG0439	Biotin carboxylase
TC41_2176	COG1960	acyl-CoA dehydrogenase activity
TC41_2177	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TC41_2179	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
TC41_2180	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
TC41_2184	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
TC41_2185	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
TC41_2185	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
TC41_2187	COG1028	Short-chain dehydrogenase reductase Sdr
TC41_2189	COG2211	Major facilitator Superfamily
TC41_2190	COG0667	Aldo Keto reductase
TC41_2191	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
TC41_2193	COG1210	Utp--glucose-1-phosphate uridylyltransferase
TC41_2195	COG1074	ATP-dependent DNA helicase activity
TC41_2196	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
TC41_2197	COG0477	Major facilitator Superfamily
TC41_2198	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
TC41_2203	COG1686	Belongs to the peptidase S11 family
TC41_2204	COG1321	iron dependent repressor
TC41_2207	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
TC41_2212	COG5001	Diguanylate cyclase
TC41_2215	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
TC41_2216	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
TC41_2217	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
TC41_2217	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
TC41_2218	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
TC41_2219	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
TC41_2220	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
TC41_2222	COG2244	polysaccharide biosynthetic process
TC41_2223	COG2323	membrane
TC41_2224	COG3706	GGDEF domain
TC41_2228	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
TC41_2231	COG1191	sigma factor activity
TC41_2232	COG2255	four-way junction helicase activity
TC41_2233	COG0632	four-way junction helicase activity
TC41_2234	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
TC41_2236	COG0217	transcriptional regulatory protein
TC41_2238	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
TC41_2238	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
TC41_2243	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
TC41_2245	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
TC41_2246	COG1193	negative regulation of DNA recombination
TC41_2249	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
TC41_2250	COG0072	phenylalanine-tRNA ligase activity
TC41_2250	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TC41_2251	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
TC41_2253	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
TC41_2254	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
TC41_2255	COG1830	Aldolase
TC41_2256	COG0205	6-phosphofructokinase activity
TC41_2257	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
TC41_2258	COG0840	transmembrane signaling receptor activity
TC41_2260	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
TC41_2261	COG3842	ATPase activity
TC41_2264	COG0579	oxidoreductase
TC41_2265	COG0508	dehydrogenase complex catalyzes the overall conversion of
TC41_2266	COG0567	Dehydrogenase, E1 component
TC41_2268	COG0714	Associated with various cellular activities
TC41_2271	COG1482	cell wall glycoprotein biosynthetic process
TC41_2272	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
TC41_2276	COG0673	inositol 2-dehydrogenase activity
TC41_2277	COG1082	Xylose isomerase domain protein TIM barrel
TC41_2282	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TC41_2283	COG0697	spore germination
TC41_2284	COG1214	PFAM Peptidase M22, glycoprotease
TC41_2284	COG0456	acetyltransferase
TC41_2285	COG2267	carboxylic ester hydrolase activity
TC41_2287	COG0531	amino acid
TC41_2288	COG3546	catalase activity
TC41_2291	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
TC41_2292	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TC41_2293	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
TC41_2294	COG0291	Belongs to the bacterial ribosomal protein bL35 family
TC41_2299	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
TC41_2304	COG1070	Carbohydrate kinase
TC41_2305	COG2115	Belongs to the xylose isomerase family
TC41_2307	COG1408	metallophosphoesterase
TC41_2311	COG0300	oxidoreductase activity
TC41_2322	COG1278	Cold shock
TC41_2325	COG0667	Aldo Keto reductase
TC41_2326	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
TC41_2331	COG4989	oxidoreductase activity
TC41_2332	COG1082	Xylose isomerase domain protein TIM barrel
TC41_2334	COG2154	pterin-4-alpha-carbinolamine dehydratase
TC41_2337	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
TC41_2339	COG0438	transferase activity, transferring glycosyl groups
TC41_2341	COG0577	efflux transmembrane transporter activity
TC41_2342	COG0577	efflux transmembrane transporter activity
TC41_2342	COG1136	(ABC) transporter
TC41_2345	COG0517	IMP dehydrogenase activity
TC41_2347	COG0372	Belongs to the citrate synthase family
TC41_2348	COG1971	Probably functions as a manganese efflux pump
TC41_2349	COG0285	dihydrofolate synthase activity
TC41_2350	COG0066	3-isopropylmalate dehydratase activity
TC41_2351	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
TC41_2352	COG0473	3-isopropylmalate dehydrogenase activity
TC41_2353	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
TC41_2354	COG0440	acetolactate synthase activity
TC41_2355	COG0028	Belongs to the TPP enzyme family
TC41_2356	COG0129	dihydroxy-acid dehydratase activity
TC41_2358	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
TC41_2359	COG0460	homoserine dehydrogenase
TC41_2364	COG1653	transport
TC41_2369	COG0450	alkyl hydroperoxide reductase
TC41_2370	COG1959	2 iron, 2 sulfur cluster binding
TC41_2371	COG1959	2 iron, 2 sulfur cluster binding
TC41_2376	COG2002	toxin-antitoxin pair type II binding
TC41_2392	COG2200	EAL domain
TC41_2408	COG3437	response regulator, receiver
TC41_2417	COG3617	BRO family, N-terminal domain
TC41_2427	COG0750	zinc metalloprotease
TC41_2438	COG1475	DNA binding
TC41_2457	COG0338	D12 class N6 adenine-specific DNA methyltransferase
TC41_2460	COG0750	zinc metalloprotease
TC41_2465	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
TC41_2469	COG1595	DNA-templated transcription, initiation
TC41_2473	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
TC41_2479	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
TC41_2480	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
TC41_2490	COG0592	DNA-directed DNA polymerase activity
TC41_2502	COG3617	BRO family, N-terminal domain
TC41_2515	COG1396	sequence-specific DNA binding
TC41_2521	COG1388	LysM domain
TC41_2521	COG3858	chitin binding
TC41_2523	COG0833	amino acid
TC41_2530	COG1132	(ABC) transporter
TC41_2531	COG1132	(ABC) transporter
TC41_2534	COG0747	negative chemotaxis
TC41_2535	COG0601	transmembrane transport
TC41_2536	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TC41_2537	COG0747	negative chemotaxis
TC41_2538	COG4608	Belongs to the ABC transporter superfamily
TC41_2539	COG0444	Belongs to the ABC transporter superfamily
TC41_2540	COG0745	RESPONSE REGULATOR receiver
TC41_2542	COG0095	Lipoate-protein ligase
TC41_2543	COG5002	protein histidine kinase activity
TC41_2544	COG0745	RESPONSE REGULATOR receiver
TC41_2545	COG0583	DNA-binding transcription factor activity
TC41_2546	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
TC41_2547	COG2972	Histidine kinase
TC41_2552	COG4753	response regulator
TC41_2552	COG2207	Transcriptional regulator
TC41_2555	COG1172	Belongs to the binding-protein-dependent transport system permease family
TC41_2556	COG1129	ABC transporter
TC41_2557	COG0708	Exodeoxyribonuclease III
TC41_2562	COG1072	(Pantothenic acid kinase))
TC41_2563	COG1132	(ABC) transporter
TC41_2564	COG1132	(ABC) transporter
TC41_2567	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
TC41_2569	COG0483	inositol monophosphate 1-phosphatase activity
TC41_2570	COG1312	Catalyzes the dehydration of D-mannonate
TC41_2571	COG0352	thiamine-phosphate diphosphorylase activity
TC41_2573	COG1929	Belongs to the glycerate kinase type-1 family
TC41_2584	COG2814	Major facilitator Superfamily
TC41_2587	COG0840	transmembrane signaling receptor activity
TC41_2590	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
TC41_2597	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
TC41_2600	COG2814	Major facilitator Superfamily
TC41_2604	COG1349	DNA-binding transcription factor activity
TC41_2605	COG1085	galactose-1-phosphate uridylyltransferase
TC41_2606	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
TC41_2611	COG1063	alcohol dehydrogenase
TC41_2613	COG0768	penicillin binding
TC41_2620	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
TC41_2623	COG1827	regulation of RNA biosynthetic process
TC41_2626	COG0237	dephospho-CoA kinase activity
TC41_2627	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
TC41_2630	COG1605	Chorismate mutase
TC41_2630	COG0077	Prephenate dehydratase
TC41_2632	COG0538	isocitrate dehydrogenase activity
TC41_2634	COG0745	RESPONSE REGULATOR receiver
TC41_2635	COG0180	Tryptophanyl-tRNA synthetase
TC41_2636	COG0469	pyruvate kinase activity
TC41_2637	COG0825	malonyl-CoA metabolic process
TC41_2638	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
TC41_2640	COG0587	DNA-directed DNA polymerase activity
TC41_2641	COG4109	DRTGG domain
TC41_2647	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
TC41_2648	COG1438	arginine binding
TC41_2650	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
TC41_2655	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
TC41_2656	COG3679	Belongs to the UPF0342 family
TC41_2657	COG2346	COG2346, Truncated hemoglobins
TC41_2659	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
TC41_2663	COG2267	carboxylic ester hydrolase activity
TC41_2665	COG1045	serine acetyltransferase
TC41_2666	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TC41_2668	COG4496	protein, YerC YecD
TC41_2670	COG2132	Multicopper oxidase
TC41_2679	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
TC41_2683	COG1063	alcohol dehydrogenase
TC41_2684	COG1960	acyl-CoA dehydrogenase activity
TC41_2685	COG0318	PFAM AMP-dependent synthetase and ligase
TC41_2686	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
TC41_2687	COG1028	Short-chain dehydrogenase reductase Sdr
TC41_2688	COG1902	pentaerythritol trinitrate reductase activity
TC41_2688	COG0446	pyridine nucleotide-disulphide oxidoreductase
TC41_2689	COG0318	PFAM AMP-dependent synthetase and ligase
TC41_2690	COG1960	acyl-CoA dehydrogenase activity
TC41_2691	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
TC41_2694	COG1376	ErfK ybiS ycfS ynhG family protein
TC41_2700	COG1028	Short-chain dehydrogenase reductase Sdr
TC41_2701	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
TC41_2703	COG0667	Aldo Keto reductase
TC41_2705	COG0840	transmembrane signaling receptor activity
TC41_2707	COG0788	formyltetrahydrofolate deformylase activity
TC41_2710	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
TC41_2710	COG1587	Uroporphyrinogen-III synthase
TC41_2711	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
TC41_2712	COG0175	sulfate reduction
TC41_2713	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
TC41_2713	COG1648	precorrin-2 dehydrogenase activity
TC41_2715	COG0463	Glycosyl transferase, family 2
TC41_2716	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
TC41_2717	COG1210	Utp--glucose-1-phosphate uridylyltransferase
TC41_2718	COG2814	Major facilitator Superfamily
TC41_2719	COG1566	PFAM secretion protein HlyD family protein
TC41_2721	COG1215	transferase activity, transferring glycosyl groups
TC41_2722	COG3103	Sh3 type 3 domain protein
TC41_2722	COG1388	LysM domain
TC41_2722	COG0791	NLP P60 protein
TC41_2723	COG1809	phosphosulfolactate synthase activity
TC41_2725	COG0531	amino acid
TC41_2728	COG0697	spore germination
TC41_2729	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TC41_2730	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
TC41_2730	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
TC41_2732	COG1562	ergosterol biosynthetic process
TC41_2733	COG1657	PFAM Prenyltransferase squalene oxidase
TC41_2734	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
TC41_2736	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
TC41_2737	COG1304	FMN binding
TC41_2738	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
TC41_2746	COG2132	Multicopper oxidase
TC41_2747	COG2132	Multicopper oxidase
TC41_2749	COG0395	ABC-type sugar transport system, permease component
TC41_2750	COG1175	transmembrane transport
TC41_2753	COG0673	inositol 2-dehydrogenase activity
TC41_2755	COG1609	Transcriptional regulator
TC41_2759	COG0174	glutamine synthetase
TC41_2760	COG0004	ammonium transporteR
TC41_2761	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
TC41_2764	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TC41_2765	COG0601	transmembrane transport
TC41_2766	COG4166	transmembrane transport
TC41_2768	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
TC41_2769	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
TC41_2770	COG0157	Belongs to the NadC ModD family
TC41_2772	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
TC41_2773	COG2022	thiamine diphosphate biosynthetic process
TC41_2775	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TC41_2776	COG0352	thiamine-phosphate diphosphorylase activity
TC41_2777	COG1227	inorganic diphosphatase activity
TC41_2779	COG2814	Major facilitator Superfamily
TC41_2782	COG0789	Transcriptional regulator
TC41_2786	COG1090	epimerase
TC41_2787	COG2271	Major facilitator Superfamily
TC41_2793	COG1215	transferase activity, transferring glycosyl groups
TC41_2799	COG0693	protein deglycase activity
TC41_2802	COG0840	transmembrane signaling receptor activity
TC41_2803	COG0531	amino acid
TC41_2804	COG1012	belongs to the aldehyde dehydrogenase family
TC41_2808	COG0463	Glycosyl transferase, family 2
TC41_2808	COG0457	Tetratricopeptide repeat
TC41_2810	COG0583	DNA-binding transcription factor activity
TC41_2812	COG2271	Major facilitator Superfamily
TC41_2814	COG1063	alcohol dehydrogenase
TC41_2816	COG0450	alkyl hydroperoxide reductase
TC41_2817	COG0735	belongs to the Fur family
TC41_2818	COG0318	PFAM AMP-dependent synthetase and ligase
TC41_2820	COG1113	amino acid transport
TC41_2822	COG2204	response regulator
TC41_2823	COG0277	FAD linked oxidase domain protein
TC41_2824	COG2271	Major facilitator Superfamily
TC41_2825	COG2267	carboxylic ester hydrolase activity
TC41_2827	COG1620	l-lactate permease
TC41_2829	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
TC41_2830	COG1414	Transcriptional regulator
TC41_2831	COG0277	FAD linked oxidase domain protein
TC41_2832	COG0247	lactate metabolic process
TC41_2833	COG0277	FAD linked oxidase domain protein
TC41_2834	COG1215	transferase activity, transferring glycosyl groups
TC41_2842	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
TC41_2843	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
TC41_2844	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
TC41_2846	COG0653	protein targeting
TC41_2847	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
TC41_2848	COG0438	transferase activity, transferring glycosyl groups
TC41_2851	COG0463	Glycosyl transferase, family 2
TC41_2851	COG0457	Tetratricopeptide repeat
TC41_2854	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
TC41_2861	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
TC41_2862	COG5002	protein histidine kinase activity
TC41_2863	COG0745	RESPONSE REGULATOR receiver
TC41_2866	COG2197	response regulator
TC41_2871	COG2814	Major facilitator Superfamily
TC41_2872	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TC41_2873	COG0412	Dienelactone hydrolase
TC41_2874	COG0521	Mo-molybdopterin cofactor biosynthetic process
TC41_2875	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
TC41_2876	COG1073	alpha beta
TC41_2879	COG0384	phenazine biosynthesis protein PhzF
TC41_2880	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
TC41_2883	COG1187	pseudouridine synthase activity
TC41_2890	COG0667	Aldo Keto reductase
TC41_2891	COG0785	Cytochrome C biogenesis protein
TC41_2892	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
TC41_2900	COG0477	Major facilitator Superfamily
TC41_2901	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
TC41_2902	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
TC41_2905	COG2814	Major facilitator Superfamily
TC41_2908	COG0803	Belongs to the bacterial solute-binding protein 9 family
TC41_2912	COG1607	acyl-coa hydrolase
TC41_2916	COG3300	MHYT domain
TC41_2916	COG5001	Diguanylate cyclase
TC41_2917	COG0673	inositol 2-dehydrogenase activity
TC41_2921	COG2372	response to copper ion
TC41_2921	COG1276	copper resistance
TC41_2922	COG4549	nuclear export factor GLE1
TC41_2923	COG0306	phosphate transporter
TC41_2928	COG0395	ABC-type sugar transport system, permease component
TC41_2930	COG1175	transmembrane transport
TC41_2933	COG0671	phosphoesterase, PA-phosphatase related
TC41_2936	COG1595	DNA-templated transcription, initiation
TC41_2941	COG1937	Protein conserved in bacteria
TC41_2943	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
TC41_2943	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TC41_2944	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
TC41_2944	COG0425	Belongs to the sulfur carrier protein TusA family
TC41_2946	COG2210	Belongs to the sulfur carrier protein TusA family
TC41_2948	COG0730	response to heat
TC41_2953	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
TC41_2954	COG1518	maintenance of DNA repeat elements
TC41_2963	COG0338	D12 class N6 adenine-specific DNA methyltransferase
TC41_2964	COG2608	mercury ion transmembrane transporter activity
TC41_2965	COG1937	Protein conserved in bacteria
TC41_2967	COG1302	Protein conserved in bacteria
TC41_2971	COG1302	Protein conserved in bacteria
TC41_2972	COG1522	sequence-specific DNA binding
TC41_2973	COG0436	Aminotransferase
TC41_2974	COG2271	Major facilitator Superfamily
TC41_2975	COG1064	alcohol dehydrogenase
TC41_2976	COG1309	transcriptional regulator
TC41_2977	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
TC41_2979	COG4372	Transposase
TC41_2986	COG4372	Transposase
TC41_2988	COG3328	transposase activity
TC41_2997	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
TC41_2998	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TC41_3000	COG4856	YbbR-like protein
TC41_3001	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
TC41_3002	COG0726	polysaccharide deacetylase
TC41_3005	COG0489	protein tyrosine kinase activity
TC41_3007	COG0860	N-Acetylmuramoyl-L-alanine amidase
TC41_3008	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
TC41_3009	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
TC41_3010	COG0101	tRNA pseudouridine synthase activity
TC41_3011	COG0203	ribosomal protein L17
TC41_3012	COG0202	RNA polymerase activity
TC41_3013	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
TC41_3014	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
TC41_3015	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
TC41_3016	COG0257	Belongs to the bacterial ribosomal protein bL36 family
TC41_3017	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
TC41_3019	COG0563	adenylate kinase activity
TC41_3020	COG0201	protein transport
TC41_3022	COG1841	ribosomal large subunit assembly
TC41_3023	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
TC41_3025	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
TC41_3026	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
TC41_3027	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
TC41_3028	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
TC41_3029	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
TC41_3030	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
TC41_3031	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
TC41_3032	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
TC41_3033	COG0255	Belongs to the universal ribosomal protein uL29 family
TC41_3034	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
TC41_3035	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
TC41_3036	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
TC41_3037	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
TC41_3038	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
TC41_3039	COG0089	rRNA binding
TC41_3040	COG0088	Forms part of the polypeptide exit tunnel
TC41_3041	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
TC41_3042	COG0051	transcription antitermination factor activity, RNA binding
TC41_3043	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
TC41_3044	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
TC41_3047	COG1358	cellular component organization or biogenesis
TC41_3048	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
TC41_3049	COG0085	RNA polymerase activity
TC41_3050	COG2813	Specifically methylates the guanine in position
TC41_3051	COG0222	ribosome binding
TC41_3052	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
TC41_3053	COG0081	regulation of translation
TC41_3054	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
TC41_3055	COG0250	Participates in transcription elongation, termination and antitermination
TC41_3057	COG0267	Belongs to the bacterial ribosomal protein bL33 family
TC41_3060	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TC41_3061	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
TC41_3062	COG0215	cysteine-tRNA ligase activity
TC41_3063	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
TC41_3064	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
TC41_3065	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
TC41_3066	COG4956	integral membrane protein (PIN domain superfamily)
TC41_3067	COG1183	phosphatidylcholine synthase activity
TC41_3068	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
TC41_3069	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
TC41_3070	COG0542	response to heat
TC41_3071	COG3869	Catalyzes the specific phosphorylation of arginine residues in
TC41_3072	COG3880	PFAM UvrB UvrC protein
TC41_3073	COG4463	regulation of RNA biosynthetic process
TC41_3079	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
TC41_3080	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
TC41_3081	COG4786	Flagellar basal body rod
TC41_3082	COG4786	Flagellar basal body rod
TC41_3084	COG1609	Transcriptional regulator
TC41_3085	COG0739	heme binding
TC41_3087	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
TC41_3091	COG0355	proton-transporting ATP synthase activity, rotational mechanism
TC41_3092	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
TC41_3093	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
TC41_3094	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
TC41_3095	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
TC41_3096	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
TC41_3097	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
TC41_3098	COG0356	it plays a direct role in the translocation of protons across the membrane
TC41_3101	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
TC41_3102	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
TC41_3103	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
TC41_3104	COG4475	Protein of unknown function (DUF436)
TC41_3106	COG1971	Probably functions as a manganese efflux pump
TC41_3109	COG3619	membrane
TC41_3113	COG0009	L-threonylcarbamoyladenylate synthase
TC41_3115	COG2890	protein-(glutamine-N5) methyltransferase activity
TC41_3116	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
TC41_3117	COG0254	rRNA binding
TC41_3120	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
TC41_3122	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
TC41_3124	COG0504	CTP synthase activity
TC41_3126	COG3343	RNA polymerase activity
TC41_3127	COG1024	Enoyl-CoA hydratase
TC41_3128	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
TC41_3129	COG1984	allophanate hydrolase subunit 2
TC41_3130	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
TC41_3131	COG1216	Glycosyl transferase, family 2
TC41_3134	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
TC41_3135	COG1960	acyl-CoA dehydrogenase activity
TC41_3136	COG1028	Short-chain dehydrogenase reductase Sdr
TC41_3136	COG0604	alcohol dehydrogenase
TC41_3136	COG3321	synthase
TC41_3137	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
TC41_3144	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
TC41_3145	COG1803	Methylglyoxal synthase
TC41_3147	COG0006	proline dipeptidase activity
TC41_3153	COG2271	Major facilitator Superfamily
TC41_3154	COG1070	Carbohydrate kinase
TC41_3163	COG0302	gtp cyclohydrolase
TC41_3167	COG2124	cytochrome p450
TC41_3169	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
TC41_3174	COG2318	DinB family
TC41_3180	COG1609	Transcriptional regulator
TC41_3181	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
TC41_3182	COG0813	purine-nucleoside phosphorylase activity
TC41_3183	COG2171	N-acyltransferase activity
TC41_3184	COG1473	amidohydrolase
TC41_3186	COG0436	Aminotransferase
TC41_3190	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
TC41_3191	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
TC41_3193	COG4208	sulfate ABC transporter
TC41_3194	COG0789	Transcriptional regulator
TC41_3195	COG1960	acyl-CoA dehydrogenase activity
TC41_3196	COG0318	PFAM AMP-dependent synthetase and ligase
TC41_3197	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
TC41_3199	COG0390	transport system, permease component
TC41_3200	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
TC41_3201	COG2130	NADP-dependent
TC41_3206	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
TC41_3209	COG3706	GGDEF domain
TC41_3213	COG1609	Transcriptional regulator
TC41_3214	COG3833	ABC-type maltose transport systems, permease component
TC41_3215	COG1175	transmembrane transport
TC41_3220	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
TC41_3223	COG0477	Major facilitator Superfamily
TC41_3233	COG1203	CRISPR-associated helicase, Cas3
TC41_3239	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
TC41_3240	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
TC41_3241	COG0179	Fumarylacetoacetate (FAA) hydrolase
TC41_3242	COG1501	Belongs to the glycosyl hydrolase 31 family
TC41_3243	COG0589	response to stress
TC41_3244	COG4166	transmembrane transport
TC41_3246	COG1874	Beta-galactosidase
TC41_3247	COG0004	ammonium transporteR
TC41_3248	COG0347	Belongs to the P(II) protein family
TC41_3256	COG3534	alpha-L-arabinofuranosidase
TC41_3257	COG0395	ABC-type sugar transport system, permease component
TC41_3262	COG2160	L-arabinose isomerase activity
TC41_3264	COG1069	ribulokinase activity
TC41_3265	COG2814	Major facilitator Superfamily
TC41_3267	COG1609	Transcriptional regulator
TC41_3271	COG2814	Major facilitator Superfamily
TC41_3272	COG1566	PFAM secretion protein HlyD family protein
TC41_3273	COG0484	heat shock protein binding
TC41_3274	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
TC41_3275	COG3300	MHYT domain
TC41_3275	COG5001	Diguanylate cyclase
TC41_3277	COG0583	DNA-binding transcription factor activity
TC41_3279	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TC41_3280	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
TC41_3283	COG5002	protein histidine kinase activity
TC41_3284	COG0745	RESPONSE REGULATOR receiver
TC41_3286	COG0305	Participates in initiation and elongation during chromosome replication
TC41_3287	COG0359	binds to the 23S rRNA
TC41_3289	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
TC41_3290	COG0629	single-stranded DNA binding
TC41_3291	COG0360	Binds together with S18 to 16S ribosomal RNA
TC41_3292	COG0012	GTP binding
TC41_3293	COG0243	molybdopterin cofactor binding
TC41_3294	COG4481	Protein conserved in bacteria
TC41_3295	COG0668	transmembrane transport
TC41_3299	COG1811	Na channel or pump
TC41_3300	COG1475	DNA binding
TC41_3301	COG1192	Involved in chromosome partitioning
TC41_3302	COG1475	DNA binding
TC41_3303	COG0357	Ribosomal RNA small subunit methyltransferase G
TC41_3304	COG0445	tRNA wobble uridine modification
TC41_3305	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
TC41_3306	COG1847	R3H domain protein
TC41_3308	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
TC41_3310	COG0230	Belongs to the bacterial ribosomal protein bL34 family