locus-tag	class	description
K1I37_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
K1I37_00010	COG0592	DNA-directed DNA polymerase activity
K1I37_00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
K1I37_00025	COG0187	DNA topoisomerase II activity
K1I37_00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
K1I37_00035	COG2329	Antibiotic biosynthesis monooxygenase
K1I37_00060	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
K1I37_00075	COG0516	GMP reductase activity
K1I37_00075	COG0517	IMP dehydrogenase activity
K1I37_00080	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
K1I37_00085	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
K1I37_00105	COG0582	viral genome integration into host DNA
K1I37_00265	COG3328	transposase activity
K1I37_00315	COG4372	Transposase
K1I37_00355	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
K1I37_00465	COG0675	Transposase, IS605 OrfB family
K1I37_00470	COG1518	maintenance of DNA repeat elements
K1I37_00470	COG1468	defense response to virus
K1I37_00475	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
K1I37_00480	COG1349	DNA-binding transcription factor activity
K1I37_00485	COG1063	alcohol dehydrogenase
K1I37_00490	COG1028	Short-chain dehydrogenase reductase Sdr
K1I37_00495	COG0698	ribose 5-phosphate isomerase
K1I37_00500	COG2376	Dihydroxyacetone kinase
K1I37_00510	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
K1I37_00515	COG2814	Major facilitator Superfamily
K1I37_00545	COG1940	carbohydrate kinase activity
K1I37_00545	COG1846	Transcriptional regulator
K1I37_00550	COG1262	PFAM Formylglycine-generating sulfatase enzyme
K1I37_00555	COG1522	sequence-specific DNA binding
K1I37_00560	COG1363	Peptidase, m42
K1I37_00565	COG0747	negative chemotaxis
K1I37_00575	COG3483	tryptophan 2,3-dioxygenase activity
K1I37_00580	COG3844	kynureninase activity
K1I37_00585	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
K1I37_00615	COG0840	transmembrane signaling receptor activity
K1I37_00615	COG3290	protein histidine kinase activity
K1I37_00620	COG0579	oxidoreductase
K1I37_00645	COG2814	Major facilitator Superfamily
K1I37_00670	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
K1I37_00675	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
K1I37_00680	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
K1I37_00685	COG2068	MobA-Related Protein
K1I37_00690	COG1012	belongs to the aldehyde dehydrogenase family
K1I37_00695	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
K1I37_00700	COG1802	Transcriptional regulator
K1I37_00705	COG0477	Major facilitator Superfamily
K1I37_00720	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K1I37_00725	COG0129	dihydroxy-acid dehydratase activity
K1I37_00730	COG0477	Major facilitator Superfamily
K1I37_00750	COG0235	Class ii aldolase
K1I37_00755	COG1063	alcohol dehydrogenase
K1I37_00765	COG2271	Major facilitator Superfamily
K1I37_00780	COG1271	oxidase subunit
K1I37_00785	COG1294	oxidase, subunit
K1I37_00790	COG4988	ABC transporter
K1I37_00795	COG1132	(ABC) transporter
K1I37_00805	COG1733	regulation of RNA biosynthetic process
K1I37_00815	COG3069	C4-dicarboxylate transmembrane transporter activity
K1I37_00820	COG2986	histidine ammonia-lyase
K1I37_00825	COG2508	Transcriptional regulator
K1I37_00830	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
K1I37_00850	COG0693	protein deglycase activity
K1I37_00865	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
K1I37_00895	COG0004	ammonium transporteR
K1I37_00900	COG0174	glutamine synthetase
K1I37_00920	COG0477	Major facilitator Superfamily
K1I37_00925	COG5002	protein histidine kinase activity
K1I37_00930	COG0534	Mate efflux family protein
K1I37_00950	COG4191	Histidine kinase
K1I37_00970	COG0791	NLP P60 protein
K1I37_00970	COG1388	LysM domain
K1I37_00970	COG3103	Sh3 type 3 domain protein
K1I37_01010	COG1435	thymidine kinase activity
K1I37_01025	COG1940	carbohydrate kinase activity
K1I37_01030	COG4213	ABC transporter substrate-binding protein
K1I37_01040	COG4214	carbohydrate transport
K1I37_01045	COG4213	ABC transporter substrate-binding protein
K1I37_01050	COG2309	aminopeptidase activity
K1I37_01060	COG1309	transcriptional regulator
K1I37_01065	COG1511	domain protein
K1I37_01075	COG3973	AAA domain
K1I37_01080	COG0697	spore germination
K1I37_01085	COG1940	carbohydrate kinase activity
K1I37_01130	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
K1I37_01135	COG1850	ribulose-bisphosphate carboxylase activity
K1I37_01140	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
K1I37_01145	COG0235	Class ii aldolase
K1I37_01150	COG0367	asparagine synthase
K1I37_01180	COG3852	Histidine kinase
K1I37_01190	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
K1I37_01195	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
K1I37_01210	COG2244	polysaccharide biosynthetic process
K1I37_01225	COG1982	Orn Lys Arg decarboxylase major
K1I37_01230	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
K1I37_01235	COG3870	Protein conserved in bacteria
K1I37_01245	COG1774	PSP1 C-terminal conserved region
K1I37_01250	COG4467	Involved in initiation control of chromosome replication
K1I37_01255	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
K1I37_01260	COG2002	toxin-antitoxin pair type II binding
K1I37_01270	COG0084	hydrolase, TatD family'
K1I37_01275	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
K1I37_01280	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
K1I37_01300	COG4466	Protein conserved in bacteria
K1I37_01315	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
K1I37_01315	COG1181	Belongs to the D-alanine--D-alanine ligase family
K1I37_01320	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
K1I37_01325	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
K1I37_01330	COG0251	oxidation-reduction process
K1I37_01335	COG2088	sporulation resulting in formation of a cellular spore
K1I37_01340	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
K1I37_01350	COG0193	aminoacyl-tRNA hydrolase activity
K1I37_01360	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
K1I37_01365	COG2002	toxin-antitoxin pair type II binding
K1I37_01370	COG2244	polysaccharide biosynthetic process
K1I37_01375	COG3956	TIGRFAM MazG family protein
K1I37_01385	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
K1I37_01405	COG1098	S1 RNA binding domain
K1I37_01425	COG2131	deaminase
K1I37_01430	COG2208	phosphoserine phosphatase activity
K1I37_01435	COG2304	oxidoreductase activity
K1I37_01455	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
K1I37_01465	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
K1I37_01470	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
K1I37_01475	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
K1I37_01480	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
K1I37_01485	COG1396	sequence-specific DNA binding
K1I37_01490	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
K1I37_01495	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
K1I37_01515	COG1309	transcriptional regulator
K1I37_01520	COG4463	regulation of RNA biosynthetic process
K1I37_01525	COG3880	PFAM UvrB UvrC protein
K1I37_01530	COG3869	Catalyzes the specific phosphorylation of arginine residues in
K1I37_01535	COG0542	response to heat
K1I37_01540	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
K1I37_01545	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
K1I37_01550	COG1183	phosphatidylcholine synthase activity
K1I37_01555	COG4956	integral membrane protein (PIN domain superfamily)
K1I37_01560	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
K1I37_01565	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
K1I37_01570	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
K1I37_01575	COG0215	cysteine-tRNA ligase activity
K1I37_01580	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
K1I37_01585	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
K1I37_01590	COG3688	RNA-binding protein containing a PIN domain
K1I37_01600	COG0267	Belongs to the bacterial ribosomal protein bL33 family
K1I37_01610	COG0250	Participates in transcription elongation, termination and antitermination
K1I37_01620	COG0081	regulation of translation
K1I37_01630	COG0222	ribosome binding
K1I37_01635	COG2813	Specifically methylates the guanine in position
K1I37_01640	COG0085	RNA polymerase activity
K1I37_01645	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
K1I37_01650	COG1358	cellular component organization or biogenesis
K1I37_01655	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
K1I37_01660	COG0049	tRNA binding
K1I37_01665	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
K1I37_01670	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
K1I37_01675	COG0051	transcription antitermination factor activity, RNA binding
K1I37_01680	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
K1I37_01685	COG0088	Forms part of the polypeptide exit tunnel
K1I37_01690	COG0089	rRNA binding
K1I37_01695	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
K1I37_01700	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
K1I37_01705	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
K1I37_01710	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
K1I37_01715	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
K1I37_01720	COG0255	Belongs to the universal ribosomal protein uL29 family
K1I37_01730	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
K1I37_01740	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
K1I37_01745	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
K1I37_01750	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
K1I37_01755	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
K1I37_01765	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
K1I37_01775	COG0200	Binds to the 23S rRNA
K1I37_01780	COG0201	protein transport
K1I37_01785	COG0563	adenylate kinase activity
K1I37_01795	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
K1I37_01800	COG0257	Belongs to the bacterial ribosomal protein bL36 family
K1I37_01805	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
K1I37_01810	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
K1I37_01815	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
K1I37_01820	COG0202	RNA polymerase activity
K1I37_01825	COG0203	ribosomal protein L17
K1I37_01830	COG0101	tRNA pseudouridine synthase activity
K1I37_01835	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
K1I37_01840	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
K1I37_01845	COG0860	N-Acetylmuramoyl-L-alanine amidase
K1I37_01855	COG0489	protein tyrosine kinase activity
K1I37_01885	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
K1I37_01895	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
K1I37_01900	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
K1I37_01920	COG1073	alpha beta
K1I37_01930	COG0640	Transcriptional regulator
K1I37_01940	COG2720	vancomycin resistance protein
K1I37_01945	COG0346	lactoylglutathione lyase activity
K1I37_01990	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
K1I37_02015	COG1396	sequence-specific DNA binding
K1I37_02210	COG3852	Histidine kinase
K1I37_02215	COG5001	Diguanylate cyclase
K1I37_02240	COG3383	formate dehydrogenase (NAD+) activity
K1I37_02245	COG2427	Protein of unknown function (DUF1641)
K1I37_02250	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
K1I37_02265	COG4988	ABC transporter
K1I37_02275	COG1294	oxidase, subunit
K1I37_02280	COG1271	oxidase subunit
K1I37_02295	COG3328	transposase activity
K1I37_02300	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K1I37_02305	COG1982	Orn Lys Arg decarboxylase major
K1I37_02315	COG3547	Transposase (IS116 IS110 IS902 family)
K1I37_02345	COG4372	Transposase
K1I37_02355	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
K1I37_02380	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
K1I37_02450	COG4372	Transposase
K1I37_02470	COG3328	transposase activity
K1I37_02520	COG3409	Peptidoglycan-binding domain 1 protein
K1I37_02520	COG3267	Type II secretory pathway component ExeA
K1I37_02560	COG0347	Belongs to the P(II) protein family
K1I37_02565	COG0004	ammonium transporteR
K1I37_02570	COG5002	protein histidine kinase activity
K1I37_02575	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
K1I37_02580	COG0390	transport system, permease component
K1I37_02600	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
K1I37_02605	COG0436	Aminotransferase
K1I37_02610	COG1473	amidohydrolase
K1I37_02615	COG2171	N-acyltransferase activity
K1I37_02620	COG0813	purine-nucleoside phosphorylase activity
K1I37_02625	COG0572	uridine kinase
K1I37_02630	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
K1I37_02635	COG1609	Transcriptional regulator
K1I37_02640	COG1070	Carbohydrate kinase
K1I37_02645	COG2271	Major facilitator Superfamily
K1I37_02650	COG0006	proline dipeptidase activity
K1I37_02655	COG1803	Methylglyoxal synthase
K1I37_02660	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
K1I37_02690	COG0436	Aminotransferase
K1I37_02695	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
K1I37_02700	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
K1I37_02705	COG0010	Belongs to the arginase family
K1I37_02720	COG1216	Glycosyl transferase, family 2
K1I37_02725	COG2181	nitrate reductase activity
K1I37_02725	COG0247	lactate metabolic process
K1I37_02730	COG1024	Enoyl-CoA hydratase
K1I37_02735	COG3343	RNA polymerase activity
K1I37_02740	COG0504	CTP synthase activity
K1I37_02755	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
K1I37_02760	COG0254	rRNA binding
K1I37_02765	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
K1I37_02770	COG2890	protein-(glutamine-N5) methyltransferase activity
K1I37_02780	COG0009	L-threonylcarbamoyladenylate synthase
K1I37_02790	COG1904	glucuronate isomerase
K1I37_02795	COG0246	Mannitol dehydrogenase
K1I37_02800	COG2721	sulfolactate sulfo-lyase activity
K1I37_02805	COG1609	Transcriptional regulator
K1I37_02810	COG2814	Major facilitator Superfamily
K1I37_02830	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
K1I37_02835	COG4475	Protein of unknown function (DUF436)
K1I37_02840	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
K1I37_02850	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
K1I37_02860	COG0356	it plays a direct role in the translocation of protons across the membrane
K1I37_02865	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
K1I37_02870	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
K1I37_02875	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
K1I37_02880	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
K1I37_02885	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
K1I37_02890	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
K1I37_02895	COG0355	proton-transporting ATP synthase activity, rotational mechanism
K1I37_02915	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
K1I37_02930	COG0739	heme binding
K1I37_02935	COG1609	Transcriptional regulator
K1I37_02940	COG1077	Cell shape determining protein MreB Mrl
K1I37_02945	COG4786	Flagellar basal body rod
K1I37_02950	COG4786	Flagellar basal body rod
K1I37_02955	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
K1I37_02960	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
K1I37_02985	COG1739	Uncharacterized protein family UPF0029
K1I37_03000	COG0463	Glycosyl transferase, family 2
K1I37_03035	COG2814	Major facilitator Superfamily
K1I37_03045	COG1846	Transcriptional regulator
K1I37_03050	COG0477	Major facilitator Superfamily
K1I37_03055	COG1309	transcriptional regulator
K1I37_03070	COG2197	response regulator
K1I37_03105	COG0300	oxidoreductase activity
K1I37_03170	COG0577	efflux transmembrane transporter activity
K1I37_03170	COG1136	(ABC) transporter
K1I37_03175	COG0577	efflux transmembrane transporter activity
K1I37_03175	COG1136	(ABC) transporter
K1I37_03210	COG5002	protein histidine kinase activity
K1I37_03215	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
K1I37_03220	COG1210	Utp--glucose-1-phosphate uridylyltransferase
K1I37_03225	COG0463	Glycosyl transferase, family 2
K1I37_03230	COG4191	Histidine kinase
K1I37_03235	COG0028	Belongs to the TPP enzyme family
K1I37_03265	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
K1I37_03265	COG3711	transcriptional antiterminator
K1I37_03275	COG3037	sugar-specific permease SgaT UlaA
K1I37_03285	COG2814	Major facilitator Superfamily
K1I37_03310	COG1587	Uroporphyrinogen-III synthase
K1I37_03310	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
K1I37_03330	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
K1I37_03365	COG1126	abc transporter atp-binding protein
K1I37_03370	COG0765	amino acid transport
K1I37_03375	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K1I37_03380	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K1I37_03385	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
K1I37_03410	COG1289	transmembrane transporter activity
K1I37_03415	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K1I37_03420	COG3858	chitin binding
K1I37_03425	COG4193	domain, Protein
K1I37_03445	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
K1I37_03455	COG2814	Major facilitator Superfamily
K1I37_03470	COG0604	alcohol dehydrogenase
K1I37_03485	COG1063	alcohol dehydrogenase
K1I37_03555	COG0564	pseudouridine synthase activity
K1I37_03560	COG3300	MHYT domain
K1I37_03560	COG5001	Diguanylate cyclase
K1I37_03570	COG1063	alcohol dehydrogenase
K1I37_03580	COG1609	Transcriptional regulator
K1I37_03590	COG0791	NLP P60 protein
K1I37_03605	COG0667	Aldo Keto reductase
K1I37_03625	COG0667	Aldo Keto reductase
K1I37_03635	COG1285	pathogenesis
K1I37_03660	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
K1I37_03665	COG1459	type II secretion system
K1I37_03705	COG0442	prolyl-tRNA aminoacylation
K1I37_03710	COG0546	phosphoglycolate phosphatase activity
K1I37_03720	COG1192	Involved in chromosome partitioning
K1I37_03725	COG5002	protein histidine kinase activity
K1I37_03745	COG1028	Short-chain dehydrogenase reductase Sdr
K1I37_03750	COG4846	Membrane protein involved in cytochrome C biogenesis
K1I37_03760	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
K1I37_03770	COG1131	(ABC) transporter
K1I37_03785	COG1335	isochorismatase
K1I37_03790	COG2814	Major facilitator Superfamily
K1I37_03800	COG1396	sequence-specific DNA binding
K1I37_03815	COG1079	Belongs to the binding-protein-dependent transport system permease family
K1I37_03820	COG4603	Belongs to the binding-protein-dependent transport system permease family
K1I37_03825	COG3845	ABC transporter
K1I37_03830	COG1744	ABC transporter substrate-binding protein PnrA-like
K1I37_03835	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K1I37_03845	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
K1I37_03865	COG0736	holo-[acyl-carrier-protein] synthase activity
K1I37_03870	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
K1I37_03870	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
K1I37_03875	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
K1I37_03880	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
K1I37_03890	COG2337	Toxic component of a toxin-antitoxin (TA) module
K1I37_03895	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
K1I37_03900	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
K1I37_03910	COG1695	Transcriptional regulator
K1I37_03930	COG1595	DNA-templated transcription, initiation
K1I37_03935	COG5002	protein histidine kinase activity
K1I37_03970	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
K1I37_03975	COG0802	atpase or kinase
K1I37_03985	COG0456	acetyltransferase
K1I37_03990	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
K1I37_03995	COG0488	(ABC) transporter
K1I37_04000	COG0671	phosphoesterase, PA-phosphatase related
K1I37_04005	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
K1I37_04010	COG0746	molybdenum cofactor guanylyltransferase activity
K1I37_04030	COG0459	protein refolding
K1I37_04080	COG0714	Associated with various cellular activities
K1I37_04090	COG1305	Transglutaminase-like
K1I37_04095	COG0518	GMP synthase (glutamine-hydrolyzing) activity
K1I37_04095	COG0519	Catalyzes the synthesis of GMP from XMP
K1I37_04100	COG2252	PERMEase
K1I37_04105	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
K1I37_04115	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
K1I37_04120	COG0047	phosphoribosylformylglycinamidine synthase activity
K1I37_04125	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
K1I37_04130	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
K1I37_04135	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
K1I37_04140	COG0138	bifunctional purine biosynthesis protein purh
K1I37_04145	COG0151	Belongs to the GarS family
K1I37_04170	COG2318	DinB family
K1I37_04175	COG1968	undecaprenyl-diphosphatase activity
K1I37_04180	COG1215	transferase activity, transferring glycosyl groups
K1I37_04185	COG2233	PERMEase
K1I37_04190	COG2223	nitrite transmembrane transporter activity
K1I37_04195	COG0436	Aminotransferase
K1I37_04200	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
K1I37_04205	COG0175	sulfate reduction
K1I37_04225	COG1122	ATPase activity
K1I37_04230	COG1122	ATPase activity
K1I37_04235	COG1268	BioY protein
K1I37_04240	COG2807	transmembrane transport
K1I37_04245	COG2271	Major facilitator Superfamily
K1I37_04250	COG2814	Major facilitator Superfamily
K1I37_04255	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
K1I37_04265	COG2207	Transcriptional regulator
K1I37_04270	COG2182	Extracellular solute-binding protein
K1I37_04275	COG1175	transmembrane transport
K1I37_04280	COG0395	ABC-type sugar transport system, permease component
K1I37_04300	COG0492	ferredoxin-NADP+ reductase activity
K1I37_04435	COG1587	Uroporphyrinogen-III synthase
K1I37_04440	COG4948	Mandelate Racemase Muconate Lactonizing
K1I37_04445	COG2884	Cell division ATP-binding protein ftsE
K1I37_04450	COG2177	Part of the ABC transporter FtsEX involved in
K1I37_04460	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
K1I37_04465	COG1360	Flagellar Motor Protein
K1I37_04470	COG0556	nucleotide-excision repair
K1I37_04475	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
K1I37_04480	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
K1I37_04490	COG0018	arginyl-trna synthetase
K1I37_04495	COG0457	Tetratricopeptide repeat
K1I37_04500	COG1051	belongs to the nudix hydrolase family
K1I37_04505	COG1660	Displays ATPase and GTPase activities
K1I37_04510	COG0391	Required for morphogenesis under gluconeogenic growth conditions
K1I37_04515	COG1481	regulation of sporulation
K1I37_04520	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
K1I37_04540	COG1194	a g-specific adenine glycosylase
K1I37_04545	COG0670	Belongs to the BI1 family
K1I37_04570	COG0628	permease
K1I37_04585	COG1205	dead DEAH box helicase
K1I37_04585	COG1111	helicase
K1I37_04595	COG4493	Belongs to the UPF0637 family
K1I37_04600	COG0737	Belongs to the 5'-nucleotidase family
K1I37_04605	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
K1I37_04615	COG0697	spore germination
K1I37_04630	COG0328	RNA-DNA hybrid ribonuclease activity
K1I37_04635	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
K1I37_04640	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
K1I37_04650	COG0473	3-isopropylmalate dehydrogenase activity
K1I37_04670	COG0546	phosphoglycolate phosphatase activity
K1I37_04700	COG2814	Major facilitator Superfamily
K1I37_04705	COG1247	-acetyltransferase
K1I37_04720	COG0697	spore germination
K1I37_04745	COG2718	Belongs to the UPF0229 family
K1I37_04750	COG2719	SpoVR family
K1I37_04770	COG0697	spore germination
K1I37_04780	COG1827	regulation of RNA biosynthetic process
K1I37_04795	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
K1I37_04800	COG1234	tRNA 3'-trailer cleavage
K1I37_04805	COG2814	Major facilitator Superfamily
K1I37_04815	COG3263	regulation of cellular component size
K1I37_04820	COG1131	(ABC) transporter
K1I37_04830	COG0477	Major facilitator Superfamily
K1I37_04845	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
K1I37_04855	COG1845	cytochrome c oxidase, subunit III
K1I37_04865	COG1612	heme a metabolic process
K1I37_04870	COG1686	Belongs to the peptidase S11 family
K1I37_04875	COG0569	domain protein
K1I37_04880	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
K1I37_04900	COG0667	Aldo Keto reductase
K1I37_04910	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
K1I37_04915	COG1454	alcohol dehydrogenase
K1I37_04920	COG1028	Short-chain dehydrogenase reductase Sdr
K1I37_04930	COG5001	Diguanylate cyclase
K1I37_04930	COG3300	MHYT domain
K1I37_04945	COG1376	ErfK ybiS ycfS ynhG family protein
K1I37_04955	COG2149	membrane
K1I37_04960	COG1525	nuclease
K1I37_04995	COG0783	Belongs to the Dps family
K1I37_05005	COG1335	isochorismatase
K1I37_05030	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
K1I37_05040	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
K1I37_05045	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
K1I37_05050	COG0154	amidase activity
K1I37_05055	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
K1I37_05060	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
K1I37_05070	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K1I37_05075	COG1869	D-ribose catabolic process
K1I37_05080	COG1129	ABC transporter
K1I37_05085	COG1172	Belongs to the binding-protein-dependent transport system permease family
K1I37_05105	COG3328	transposase activity
K1I37_05130	COG0725	ABC transporter, periplasmic molybdate-binding protein
K1I37_05140	COG3842	ATPase activity
K1I37_05145	COG2368	4-hydroxyphenylacetate
K1I37_05155	COG2031	fatty acid transporter
K1I37_05170	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
K1I37_05180	COG3829	transcription factor binding
K1I37_05180	COG3290	protein histidine kinase activity
K1I37_05185	COG1556	Lactate utilization protein
K1I37_05190	COG1139	Iron-sulfur cluster binding protein
K1I37_05195	COG0247	lactate metabolic process
K1I37_05200	COG2186	Transcriptional regulator
K1I37_05210	COG4989	oxidoreductase activity
K1I37_05215	COG2423	ornithine cyclodeaminase activity
K1I37_05220	COG4549	nuclear export factor GLE1
K1I37_05225	COG2372	response to copper ion
K1I37_05225	COG1276	copper resistance
K1I37_05235	COG2217	Heavy metal translocating P-type atpase
K1I37_05240	COG2197	response regulator
K1I37_05245	COG4585	Histidine kinase
K1I37_05250	COG0840	transmembrane signaling receptor activity
K1I37_05260	COG2201	protein-glutamate methylesterase activity
K1I37_05270	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
K1I37_05275	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
K1I37_05280	COG0281	malic enzyme
K1I37_05285	COG0596	Alpha beta hydrolase
K1I37_05300	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
K1I37_05305	COG1846	Transcriptional regulator
K1I37_05310	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
K1I37_05330	COG2155	Conserved Protein
K1I37_05335	COG0019	diaminopimelate decarboxylase activity
K1I37_05355	COG0295	cytidine deaminase activity
K1I37_05360	COG1164	Oligoendopeptidase f
K1I37_05365	COG4191	Histidine kinase
K1I37_05375	COG0126	phosphoglycerate kinase activity
K1I37_05380	COG0149	triose-phosphate isomerase activity
K1I37_05385	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
K1I37_05390	COG0148	phosphopyruvate hydratase activity
K1I37_05395	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
K1I37_05400	COG0557	exoribonuclease II activity
K1I37_05405	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
K1I37_05440	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
K1I37_05450	COG0444	Belongs to the ABC transporter superfamily
K1I37_05455	COG4608	Belongs to the ABC transporter superfamily
K1I37_05460	COG0601	transmembrane transport
K1I37_05465	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K1I37_05475	COG0640	Transcriptional regulator
K1I37_05485	COG0393	Putative heavy-metal-binding
K1I37_05500	COG1129	ABC transporter
K1I37_05510	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
K1I37_05525	COG2814	Major facilitator Superfamily
K1I37_05555	COG2814	Major facilitator Superfamily
K1I37_05575	COG1959	2 iron, 2 sulfur cluster binding
K1I37_05580	COG0702	epimerase
K1I37_05615	COG0708	Exodeoxyribonuclease III
K1I37_05625	COG0745	RESPONSE REGULATOR receiver
K1I37_05630	COG5002	protein histidine kinase activity
K1I37_05660	COG0248	Ppx GppA phosphatase
K1I37_05670	COG3384	dioxygenase
K1I37_05675	COG0596	Alpha beta hydrolase
K1I37_05675	COG0508	dehydrogenase complex catalyzes the overall conversion of
K1I37_05680	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
K1I37_05685	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
K1I37_05705	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
K1I37_05710	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
K1I37_05715	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
K1I37_05720	COG2188	Transcriptional regulator
K1I37_05725	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
K1I37_05730	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
K1I37_05735	COG4208	sulfate ABC transporter
K1I37_05745	COG5583	Uncharacterized small protein (DUF2292)
K1I37_05750	COG0431	NADPH-dependent FMN reductase
K1I37_05755	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
K1I37_05760	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
K1I37_05765	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
K1I37_05770	COG1116	anion transmembrane transporter activity
K1I37_05775	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
K1I37_05805	COG0427	acetyl-CoA hydrolase
K1I37_05815	COG0420	3'-5' exonuclease activity
K1I37_05820	COG0419	ATPase involved in DNA repair
K1I37_05830	COG1953	Uracil, thiamine, allantoin
K1I37_05840	COG0493	'glutamate synthase
K1I37_05850	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
K1I37_05855	COG0252	asparaginase activity
K1I37_05865	COG0531	amino acid
K1I37_05875	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
K1I37_05895	COG0477	Major facilitator Superfamily
K1I37_05915	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
K1I37_05930	COG0804	urea catabolic process
K1I37_05935	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
K1I37_05940	COG0830	nickel cation binding
K1I37_05960	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
K1I37_05965	COG2115	Belongs to the xylose isomerase family
K1I37_05975	COG2814	Major facilitator Superfamily
K1I37_05980	COG3344	reverse transcriptase
K1I37_05990	COG0551	DNA topoisomerase type I activity
K1I37_05990	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
K1I37_05995	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
K1I37_05995	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
K1I37_05995	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
K1I37_06000	COG1461	Dihydroxyacetone kinase
K1I37_06005	COG2376	Dihydroxyacetone kinase
K1I37_06010	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
K1I37_06020	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
K1I37_06025	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
K1I37_06030	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K1I37_06035	COG0531	amino acid
K1I37_06040	COG0667	Aldo Keto reductase
K1I37_06045	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
K1I37_06065	COG2814	Major facilitator Superfamily
K1I37_06080	COG2271	Major facilitator Superfamily
K1I37_06085	COG4638	Rieske (2fe-2S)
K1I37_06090	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
K1I37_06095	COG1063	alcohol dehydrogenase
K1I37_06105	COG1802	Transcriptional regulator
K1I37_06115	COG0129	dihydroxy-acid dehydratase activity
K1I37_06125	COG0277	FAD linked oxidase domain protein
K1I37_06135	COG1414	Transcriptional regulator
K1I37_06155	COG4569	acetaldehyde dehydrogenase (acetylating) activity
K1I37_06170	COG1942	4-Oxalocrotonate Tautomerase
K1I37_06190	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
K1I37_06200	COG3383	formate dehydrogenase (NAD+) activity
K1I37_06210	COG2860	membrane
K1I37_06215	COG0583	DNA-binding transcription factor activity
K1I37_06220	COG1473	amidohydrolase
K1I37_06225	COG0747	negative chemotaxis
K1I37_06230	COG0697	spore germination
K1I37_06235	COG3711	transcriptional antiterminator
K1I37_06240	COG1263	PTS System
K1I37_06240	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K1I37_06245	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K1I37_06245	COG1263	PTS System
K1I37_06250	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
K1I37_06255	COG2190	(PTS) system
K1I37_06260	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
K1I37_06265	COG0363	glucosamine-6-phosphate deaminase activity
K1I37_06310	COG1216	Glycosyl transferase, family 2
K1I37_06340	COG1086	Polysaccharide biosynthesis protein
K1I37_06350	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
K1I37_06360	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
K1I37_06365	COG0463	Glycosyl transferase, family 2
K1I37_06365	COG1216	Glycosyl transferase, family 2
K1I37_06375	COG0529	Catalyzes the synthesis of activated sulfate
K1I37_06405	COG5609	conserved protein (DUF2294)
K1I37_06410	COG2116	formate transmembrane transporter activity
K1I37_06415	COG3383	formate dehydrogenase (NAD+) activity
K1I37_06440	COG3385	transposase activity
K1I37_06445	COG1376	ErfK ybiS ycfS ynhG family protein
K1I37_06450	COG1492	cobalamin metabolic process
K1I37_06465	COG0617	tRNA 3'-terminal CCA addition
K1I37_06475	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
K1I37_06485	COG1032	radical SAM domain protein
K1I37_06500	COG0542	response to heat
K1I37_06520	COG3385	transposase activity
K1I37_06525	COG3328	transposase activity
K1I37_06535	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
K1I37_06550	COG2078	PFAM AMMECR1 domain protein
K1I37_06550	COG3885	ferrous iron binding
K1I37_06555	COG2116	formate transmembrane transporter activity
K1I37_06560	COG3383	formate dehydrogenase (NAD+) activity
K1I37_06575	COG3328	transposase activity
K1I37_06580	COG1741	Belongs to the pirin family
K1I37_06600	COG1070	Carbohydrate kinase
K1I37_06605	COG1028	Short-chain dehydrogenase reductase Sdr
K1I37_06605	COG3347	Dehydrogenase
K1I37_06610	COG4952	isomerase
K1I37_06615	COG2814	Major facilitator Superfamily
K1I37_06625	COG1349	DNA-binding transcription factor activity
K1I37_06630	COG3511	phospholipase C
K1I37_06660	COG1846	Transcriptional regulator
K1I37_06680	COG0656	L-ascorbic acid biosynthetic process
K1I37_06685	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
K1I37_06690	COG4191	Histidine kinase
K1I37_06700	COG3328	transposase activity
K1I37_06705	COG0318	PFAM AMP-dependent synthetase and ligase
K1I37_06710	COG1024	Enoyl-CoA hydratase
K1I37_06725	COG0519	Catalyzes the synthesis of GMP from XMP
K1I37_06735	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
K1I37_06740	COG1028	Short-chain dehydrogenase reductase Sdr
K1I37_06745	COG0077	Prephenate dehydratase
K1I37_06745	COG1605	Chorismate mutase
K1I37_06755	COG0488	(ABC) transporter
K1I37_06760	COG0531	amino acid
K1I37_06765	COG0513	Belongs to the DEAD box helicase family
K1I37_06775	COG1119	ATPase activity
K1I37_06780	COG1671	Belongs to the UPF0178 family
K1I37_06785	COG2353	YceI-like domain
K1I37_06790	COG1733	regulation of RNA biosynthetic process
K1I37_06815	COG0529	Catalyzes the synthesis of activated sulfate
K1I37_06820	COG2046	Belongs to the sulfate adenylyltransferase family
K1I37_06825	COG0483	inositol monophosphate 1-phosphatase activity
K1I37_06835	COG2183	response to ionizing radiation
K1I37_06850	COG3153	acetyltransferase
K1I37_06850	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
K1I37_06855	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K1I37_06855	COG0723	plastoquinol--plastocyanin reductase activity
K1I37_06860	COG3361	conserved protein (COG2071)
K1I37_06865	COG3011	Protein conserved in bacteria
K1I37_06880	COG1063	alcohol dehydrogenase
K1I37_06910	COG0667	Aldo Keto reductase
K1I37_06915	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
K1I37_06920	COG0561	phosphatase activity
K1I37_06925	COG0673	inositol 2-dehydrogenase activity
K1I37_06930	COG1012	belongs to the aldehyde dehydrogenase family
K1I37_06935	COG0220	tRNA (guanine-N7-)-methyltransferase activity
K1I37_06940	COG1335	isochorismatase
K1I37_06950	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
K1I37_06955	COG0318	PFAM AMP-dependent synthetase and ligase
K1I37_06965	COG0598	Magnesium transport protein CorA
K1I37_06970	COG3973	AAA domain
K1I37_06990	COG0477	Major facilitator Superfamily
K1I37_06995	COG2814	Major facilitator Superfamily
K1I37_07010	COG1012	belongs to the aldehyde dehydrogenase family
K1I37_07015	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
K1I37_07025	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
K1I37_07040	COG1077	Cell shape determining protein MreB Mrl
K1I37_07045	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
K1I37_07050	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
K1I37_07050	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
K1I37_07050	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
K1I37_07055	COG1349	DNA-binding transcription factor activity
K1I37_07060	COG1105	Belongs to the carbohydrate kinase PfkB family
K1I37_07065	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
K1I37_07065	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
K1I37_07065	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
K1I37_07075	COG5002	protein histidine kinase activity
K1I37_07090	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K1I37_07110	COG0154	amidase activity
K1I37_07115	COG2363	Small membrane protein
K1I37_07125	COG0626	cystathionine gamma-synthase activity
K1I37_07130	COG0424	maF-like protein
K1I37_07150	COG2081	HI0933 family
K1I37_07155	COG1979	alcohol dehydrogenase
K1I37_07160	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
K1I37_07165	COG0116	Belongs to the methyltransferase superfamily
K1I37_07170	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
K1I37_07175	COG0109	protoheme IX farnesyltransferase activity
K1I37_07185	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
K1I37_07195	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
K1I37_07200	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
K1I37_07205	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
K1I37_07210	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
K1I37_07215	COG0131	Imidazoleglycerol-phosphate dehydratase
K1I37_07225	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
K1I37_07235	COG0140	phosphoribosyl-ATP diphosphatase activity
K1I37_07235	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
K1I37_07240	COG2271	Major facilitator Superfamily
K1I37_07245	COG3290	protein histidine kinase activity
K1I37_07250	COG4565	transcriptional regulatory protein
K1I37_07255	COG0667	Aldo Keto reductase
K1I37_07260	COG0697	spore germination
K1I37_07270	COG1494	fructose-1,6-bisphosphatase
K1I37_07275	COG4721	ABC-type cobalt transport system, permease component
K1I37_07280	COG1122	ATPase activity
K1I37_07295	COG1742	UPF0060 membrane protein
K1I37_07305	COG0583	DNA-binding transcription factor activity
K1I37_07310	COG2271	Major facilitator Superfamily
K1I37_07330	COG0066	3-isopropylmalate dehydratase activity
K1I37_07335	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
K1I37_07345	COG0066	3-isopropylmalate dehydratase activity
K1I37_07360	COG0583	DNA-binding transcription factor activity
K1I37_07385	COG0456	acetyltransferase
K1I37_07385	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
K1I37_07405	COG0583	DNA-binding transcription factor activity
K1I37_07415	COG1053	succinate dehydrogenase
K1I37_07420	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
K1I37_07430	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
K1I37_07435	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
K1I37_07440	COG1116	anion transmembrane transporter activity
K1I37_07445	COG0482	sulfurtransferase activity
K1I37_07475	COG1960	acyl-CoA dehydrogenase activity
K1I37_07490	COG1213	nucleotidyl transferase
K1I37_07500	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
K1I37_07535	COG0564	pseudouridine synthase activity
K1I37_07540	COG1295	ribonuclease BN
K1I37_07545	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
K1I37_07560	COG1363	Peptidase, m42
K1I37_07565	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
K1I37_07570	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
K1I37_07575	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
K1I37_07610	COG0840	transmembrane signaling receptor activity
K1I37_07645	COG0302	gtp cyclohydrolase
K1I37_07655	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
K1I37_07665	COG0167	dihydroorotate dehydrogenase activity
K1I37_07670	COG1595	DNA-templated transcription, initiation
K1I37_07685	COG0686	Belongs to the AlaDH PNT family
K1I37_07690	COG2151	metal-sulfur cluster biosynthetic enzyme
K1I37_07695	COG0396	ATPase activity
K1I37_07700	COG0719	Fe-S assembly protein
K1I37_07705	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
K1I37_07710	COG0822	iron-sulfur transferase activity
K1I37_07715	COG0719	Fe-S assembly protein
K1I37_07730	COG0789	Transcriptional regulator
K1I37_07755	COG0450	alkyl hydroperoxide reductase
K1I37_07765	COG1309	transcriptional regulator
K1I37_07770	COG2086	electron transfer activity
K1I37_07775	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
K1I37_07790	COG0114	fumarate hydratase activity
K1I37_07795	COG1506	peptidase
K1I37_07795	COG4946	Tricorn protease homolog
K1I37_07795	COG0823	Involved in the tonB-independent uptake of proteins
K1I37_07805	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
K1I37_07810	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
K1I37_07825	COG0531	amino acid
K1I37_07830	COG0438	transferase activity, transferring glycosyl groups
K1I37_07865	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
K1I37_07880	COG0583	DNA-binding transcription factor activity
K1I37_07930	COG0587	DNA-directed DNA polymerase activity
K1I37_07935	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
K1I37_07940	COG0671	phosphoesterase, PA-phosphatase related
K1I37_07955	COG0537	adenosine 5'-monophosphoramidase activity
K1I37_07960	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
K1I37_07975	COG2340	Cysteine-rich secretory protein family
K1I37_07985	COG0583	DNA-binding transcription factor activity
K1I37_08025	COG0463	Glycosyl transferase, family 2
K1I37_08030	COG1024	Enoyl-CoA hydratase
K1I37_08030	COG1250	3-hydroxyacyl-CoA dehydrogenase
K1I37_08035	COG0183	Belongs to the thiolase family
K1I37_08040	COG1960	acyl-CoA dehydrogenase activity
K1I37_08045	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
K1I37_08050	COG0768	penicillin binding
K1I37_08055	COG0477	Major facilitator Superfamily
K1I37_08070	COG0612	Peptidase, M16
K1I37_08075	COG0612	Peptidase, M16
K1I37_08080	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
K1I37_08085	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
K1I37_08090	COG0083	homoserine kinase activity
K1I37_08100	COG2050	protein possibly involved in aromatic compounds catabolism
K1I37_08110	COG1028	Short-chain dehydrogenase reductase Sdr
K1I37_08115	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K1I37_08120	COG0154	amidase activity
K1I37_08140	COG1956	GAF domain-containing protein
K1I37_08145	COG1393	Belongs to the ArsC family
K1I37_08160	COG0772	Belongs to the SEDS family
K1I37_08170	COG0584	glycerophosphoryl diester phosphodiesterase
K1I37_08175	COG0772	Belongs to the SEDS family
K1I37_08180	COG0436	Aminotransferase
K1I37_08190	COG4145	pantothenate transmembrane transporter activity
K1I37_08200	COG1085	galactose-1-phosphate uridylyltransferase
K1I37_08205	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
K1I37_08210	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
K1I37_08230	COG1982	Orn Lys Arg decarboxylase major
K1I37_08235	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
K1I37_08240	COG0316	Belongs to the HesB IscA family
K1I37_08245	COG1078	dGTPase activity
K1I37_08250	COG0586	Pfam SNARE associated Golgi protein
K1I37_08260	COG3377	Domain of unknown function (DUF1805)
K1I37_08265	COG1363	Peptidase, m42
K1I37_08270	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
K1I37_08290	COG0444	Belongs to the ABC transporter superfamily
K1I37_08295	COG4608	Belongs to the ABC transporter superfamily
K1I37_08300	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K1I37_08305	COG0601	transmembrane transport
K1I37_08310	COG0747	negative chemotaxis
K1I37_08340	COG3385	transposase activity
K1I37_08375	COG0697	spore germination
K1I37_08395	COG4221	oxidoreductase activity
K1I37_08400	COG0069	glutamate synthase activity
K1I37_08430	COG4372	Transposase
K1I37_08435	COG0531	amino acid
K1I37_08485	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K1I37_08505	COG2309	aminopeptidase activity
K1I37_08520	COG2207	Transcriptional regulator
K1I37_08535	COG0583	DNA-binding transcription factor activity
K1I37_08540	COG0583	DNA-binding transcription factor activity
K1I37_08555	COG1472	Belongs to the glycosyl hydrolase 3 family
K1I37_08560	COG2391	methyltransferase activity
K1I37_08575	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
K1I37_08590	COG2814	Major facilitator Superfamily
K1I37_08600	COG1012	belongs to the aldehyde dehydrogenase family
K1I37_08650	COG1910	domain protein
K1I37_08655	COG0251	oxidation-reduction process
K1I37_08660	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
K1I37_08665	COG4224	UPF0291 protein
K1I37_08680	COG0791	NLP P60 protein
K1I37_08740	COG0512	Glutamine amidotransferase of anthranilate synthase
K1I37_08755	COG1247	-acetyltransferase
K1I37_08775	COG1126	abc transporter atp-binding protein
K1I37_08780	COG0765	amino acid transport
K1I37_08785	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K1I37_08800	COG0163	prenyltransferase activity
K1I37_08815	COG0747	negative chemotaxis
K1I37_08820	COG2271	Major facilitator Superfamily
K1I37_08825	COG1063	alcohol dehydrogenase
K1I37_08835	COG1832	CoA-binding protein
K1I37_08845	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
K1I37_08850	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
K1I37_08855	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
K1I37_08865	COG0069	glutamate synthase activity
K1I37_08865	COG0070	glutamate synthase
K1I37_08865	COG0067	glutamate synthase
K1I37_08870	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
K1I37_08875	COG0137	argininosuccinate synthase activity
K1I37_08880	COG0165	Argininosuccinate lyase
K1I37_08890	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
K1I37_08895	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
K1I37_08920	COG2003	Belongs to the UPF0758 family
K1I37_08945	COG3328	transposase activity
K1I37_08955	COG1584	GPR1 FUN34 yaaH family protein
K1I37_08960	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
K1I37_08965	COG3906	Belongs to the UPF0473 family
K1I37_08995	COG0740	serine-type endopeptidase activity
K1I37_09000	COG1104	cysteine desulfurase activity
K1I37_09005	COG0301	tRNA thio-modification
K1I37_09030	COG1028	Short-chain dehydrogenase reductase Sdr
K1I37_09035	COG1902	pentaerythritol trinitrate reductase activity
K1I37_09040	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
K1I37_09045	COG3344	reverse transcriptase
K1I37_09050	COG2001	Belongs to the MraZ family
K1I37_09055	COG0275	rRNA processing
K1I37_09065	COG0768	penicillin binding
K1I37_09070	COG0768	penicillin binding
K1I37_09075	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
K1I37_09080	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
K1I37_09085	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
K1I37_09090	COG0772	Belongs to the SEDS family
K1I37_09095	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
K1I37_09100	COG3328	transposase activity
K1I37_09105	COG0812	UDP-N-acetylmuramate dehydrogenase activity
K1I37_09110	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
K1I37_09130	COG3856	small basic protein
K1I37_09135	COG0849	cell division
K1I37_09140	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
K1I37_09150	COG1191	sigma factor activity
K1I37_09155	COG1191	sigma factor activity
K1I37_09160	COG1873	PFAM PRC-barrel domain
K1I37_09165	COG1496	oxidoreductase activity
K1I37_09180	COG2302	S4 RNA-binding domain
K1I37_09185	COG3599	regulation of cell shape
K1I37_09205	COG1809	phosphosulfolactate synthase activity
K1I37_09210	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
K1I37_09215	COG0564	pseudouridine synthase activity
K1I37_09220	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
K1I37_09225	COG0540	Belongs to the ATCase OTCase family
K1I37_09230	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
K1I37_09235	COG0505	Belongs to the CarA family
K1I37_09245	COG0284	orotidine-5'-phosphate decarboxylase activity
K1I37_09270	COG0454	-acetyltransferase
K1I37_09275	COG1033	growth of symbiont in host cell
K1I37_09275	COG2409	Drug exporters of the RND superfamily
K1I37_09290	COG1914	H( )-stimulated, divalent metal cation uptake system
K1I37_09295	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
K1I37_09310	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
K1I37_09315	COG1561	YicC-like family, N-terminal region
K1I37_09320	COG1758	RNA polymerase activity
K1I37_09325	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
K1I37_09330	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
K1I37_09335	COG0242	peptide deformylase activity
K1I37_09340	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
K1I37_09345	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
K1I37_09345	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
K1I37_09350	COG0820	rRNA (adenine-C2-)-methyltransferase activity
K1I37_09355	COG0631	protein serine/threonine phosphatase activity
K1I37_09360	COG0515	serine threonine protein kinase
K1I37_09360	COG2815	serine threonine protein kinase
K1I37_09365	COG1162	GTPase activity
K1I37_09370	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
K1I37_09380	COG0227	Belongs to the bacterial ribosomal protein bL28 family
K1I37_09390	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
K1I37_09400	COG2011	ABC-type metal ion transport system permease component
K1I37_09405	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
K1I37_09415	COG1464	Belongs to the NlpA lipoprotein family
K1I37_09420	COG0688	phosphatidylethanolamine metabolic process
K1I37_09435	COG0154	amidase activity
K1I37_09445	COG0742	ribosomal rna small subunit methyltransferase
K1I37_09450	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
K1I37_09455	COG1752	Esterase of the alpha-beta hydrolase superfamily
K1I37_09465	COG0333	Belongs to the bacterial ribosomal protein bL32 family
K1I37_09470	COG1349	DNA-binding transcription factor activity
K1I37_09475	COG0416	fatty acid biosynthetic process
K1I37_09480	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
K1I37_09485	COG1028	Short-chain dehydrogenase reductase Sdr
K1I37_09490	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
K1I37_09495	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
K1I37_09500	COG0571	ribonuclease III activity
K1I37_09505	COG1196	nuclear chromosome segregation
K1I37_09510	COG0552	protein localization to endoplasmic reticulum
K1I37_09515	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
K1I37_09520	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
K1I37_09525	COG0228	four-way junction DNA binding
K1I37_09530	COG1837	Belongs to the UPF0109 family
K1I37_09545	COG0336	Belongs to the RNA methyltransferase TrmD family
K1I37_09565	COG3344	reverse transcriptase
K1I37_09570	COG3547	Transposase (IS116 IS110 IS902 family)
K1I37_09575	COG1733	regulation of RNA biosynthetic process
K1I37_09590	COG0318	PFAM AMP-dependent synthetase and ligase
K1I37_09595	COG1917	Cupin 2, conserved barrel domain protein
K1I37_09595	COG4977	sequence-specific DNA binding
K1I37_09600	COG1606	tRNA processing
K1I37_09605	COG1691	(AIR) carboxylase
K1I37_09635	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
K1I37_09640	COG1620	l-lactate permease
K1I37_09645	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
K1I37_09780	COG1113	amino acid transport
K1I37_09785	COG0673	inositol 2-dehydrogenase activity
K1I37_09790	COG1070	Carbohydrate kinase
K1I37_09810	COG2271	Major facilitator Superfamily
K1I37_09815	COG0473	3-isopropylmalate dehydrogenase activity
K1I37_09820	COG0564	pseudouridine synthase activity
K1I37_09830	COG0739	heme binding
K1I37_09835	COG1607	acyl-coa hydrolase
K1I37_09860	COG0335	large ribosomal subunit rRNA binding
K1I37_09870	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
K1I37_09880	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
K1I37_09885	COG0792	nuclease activity
K1I37_09890	COG0346	lactoylglutathione lyase activity
K1I37_09895	COG0561	phosphatase activity
K1I37_09925	COG0477	Major facilitator Superfamily
K1I37_09930	COG0477	Major facilitator Superfamily
K1I37_09935	COG5002	protein histidine kinase activity
K1I37_09950	COG4191	Histidine kinase
K1I37_09955	COG0606	chelatase, subunit chli
K1I37_09965	COG0045	succinate-CoA ligase (ADP-forming) activity
K1I37_09970	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
K1I37_09975	COG0758	DNA mediated transformation
K1I37_09975	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
K1I37_09985	COG3196	Protein conserved in bacteria
K1I37_10010	COG1132	(ABC) transporter
K1I37_10025	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
K1I37_10030	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
K1I37_10035	COG4974	Belongs to the 'phage' integrase family
K1I37_10040	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
K1I37_10045	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
K1I37_10065	COG1766	The M ring may be actively involved in energy transduction
K1I37_10070	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
K1I37_10080	COG1157	protein secretion by the type III secretion system
K1I37_10100	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
K1I37_10110	COG4786	Flagellar basal body rod
K1I37_10125	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
K1I37_10130	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
K1I37_10130	COG1776	CheC inhibitor of MCP methylation
K1I37_10135	COG2201	protein-glutamate methylesterase activity
K1I37_10145	COG1338	Plays a role in the flagellum-specific transport system
K1I37_10150	COG1987	bacterial-type flagellum assembly
K1I37_10155	COG1684	flagellar biosynthetic protein fliR
K1I37_10160	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
K1I37_10165	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
K1I37_10170	COG1419	protein localization to endoplasmic reticulum
K1I37_10180	COG2201	protein-glutamate methylesterase activity
K1I37_10185	COG0643	Histidine kinase
K1I37_10185	COG2198	Histidine kinase
K1I37_10190	COG0835	chemotaxis
K1I37_10200	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
K1I37_10210	COG0052	Belongs to the universal ribosomal protein uS2 family
K1I37_10215	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
K1I37_10220	COG0528	UMP kinase activity
K1I37_10225	COG0233	cytoplasmic translational termination
K1I37_10230	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
K1I37_10235	COG4589	Belongs to the CDS family
K1I37_10240	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
K1I37_10245	COG0750	zinc metalloprotease
K1I37_10255	COG1217	gtp-binding protein TYPA
K1I37_10260	COG0779	Required for maturation of 30S ribosomal subunits
K1I37_10265	COG0195	Participates in both transcription termination and antitermination
K1I37_10270	COG2740	Nucleic-acid-binding protein implicated in transcription termination
K1I37_10285	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
K1I37_10300	COG0196	riboflavin kinase activity
K1I37_10305	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
K1I37_10310	COG1185	polyribonucleotide nucleotidyltransferase activity
K1I37_10315	COG0726	polysaccharide deacetylase
K1I37_10320	COG0612	Peptidase, M16
K1I37_10330	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
K1I37_10335	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
K1I37_10340	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
K1I37_10345	COG0527	aspartate kinase activity
K1I37_10350	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
K1I37_10355	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
K1I37_10360	COG0740	serine-type endopeptidase activity
K1I37_10370	COG1674	ftsk spoiiie
K1I37_10370	COG4980	gas vesicle protein
K1I37_10395	COG1426	Protein conserved in bacteria
K1I37_10400	COG1666	GTP binding
K1I37_10405	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
K1I37_10410	COG1058	Belongs to the CinA family
K1I37_10410	COG1546	Belongs to the CinA family
K1I37_10420	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
K1I37_10430	COG1418	mRNA catabolic process
K1I37_10435	COG1692	metallophosphoesterase
K1I37_10440	COG2359	stage V sporulation protein S
K1I37_10455	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
K1I37_10470	COG0681	Belongs to the peptidase S26 family
K1I37_10480	COG0189	ligase activity
K1I37_10490	COG0189	ligase activity
K1I37_10500	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
K1I37_10510	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
K1I37_10515	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
K1I37_10520	COG2136	Putative SAM-dependent methyltransferase
K1I37_10520	COG2521	methyltransferase
K1I37_10525	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
K1I37_10570	COG1609	Transcriptional regulator
K1I37_10575	COG1653	transport
K1I37_10595	COG0697	spore germination
K1I37_10625	COG0109	protoheme IX farnesyltransferase activity
K1I37_10640	COG2197	response regulator
K1I37_10645	COG5002	protein histidine kinase activity
K1I37_10680	COG0464	growth
K1I37_10700	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
K1I37_10705	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
K1I37_10710	COG0789	Transcriptional regulator
K1I37_10715	COG0174	glutamine synthetase
K1I37_10725	COG3267	Type II secretory pathway component ExeA
K1I37_10725	COG3409	Peptidoglycan-binding domain 1 protein
K1I37_10745	COG0586	Pfam SNARE associated Golgi protein
K1I37_10750	COG0586	Pfam SNARE associated Golgi protein
K1I37_10785	COG4977	sequence-specific DNA binding
K1I37_10795	COG4166	transmembrane transport
K1I37_10800	COG1744	ABC transporter substrate-binding protein PnrA-like
K1I37_10825	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
K1I37_10835	COG0423	glycine-tRNA ligase activity
K1I37_10845	COG2814	Major facilitator Superfamily
K1I37_10850	COG0646	methionine synthase
K1I37_10850	COG1410	methionine synthase
K1I37_10855	COG0646	methionine synthase
K1I37_10855	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
K1I37_10865	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K1I37_10875	COG3842	ATPase activity
K1I37_10890	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
K1I37_10895	COG0460	homoserine dehydrogenase
K1I37_10900	COG0531	amino acid
K1I37_10935	COG4721	ABC-type cobalt transport system, permease component
K1I37_10940	COG2022	thiamine diphosphate biosynthetic process
K1I37_10950	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K1I37_10955	COG0352	thiamine-phosphate diphosphorylase activity
K1I37_10960	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
K1I37_10965	COG0352	thiamine-phosphate diphosphorylase activity
K1I37_11010	COG0582	viral genome integration into host DNA
K1I37_11035	COG3328	transposase activity
K1I37_11045	COG3328	transposase activity
K1I37_11055	COG1247	-acetyltransferase
K1I37_11060	COG1247	-acetyltransferase
K1I37_11090	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
K1I37_11100	COG0735	belongs to the Fur family
K1I37_11105	COG0450	alkyl hydroperoxide reductase
K1I37_11150	COG2096	Adenosyltransferase
K1I37_11155	COG2808	Putative FMN-binding domain
K1I37_11165	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
K1I37_11180	COG3328	transposase activity
K1I37_11185	COG0346	lactoylglutathione lyase activity
K1I37_11235	COG1846	Transcriptional regulator
K1I37_11240	COG0508	dehydrogenase complex catalyzes the overall conversion of
K1I37_11245	COG0022	dehydrogenase e1 component
K1I37_11250	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
K1I37_11255	COG2390	Transcriptional regulator
K1I37_11265	COG3732	PTS system glucitol sorbitol-specific
K1I37_11270	COG3730	PTS system glucitol sorbitol-specific
K1I37_11285	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
K1I37_11300	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
K1I37_11305	COG0300	oxidoreductase activity
K1I37_11330	COG0667	Aldo Keto reductase
K1I37_11335	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
K1I37_11340	COG1914	H( )-stimulated, divalent metal cation uptake system
K1I37_11345	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K1I37_11360	COG0823	Involved in the tonB-independent uptake of proteins
K1I37_11360	COG1506	peptidase
K1I37_11360	COG4946	Tricorn protease homolog
K1I37_11375	COG3300	MHYT domain
K1I37_11375	COG5001	Diguanylate cyclase
K1I37_11380	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
K1I37_11385	COG1181	Belongs to the D-alanine--D-alanine ligase family
K1I37_11390	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
K1I37_11395	COG3935	DnaD domain protein
K1I37_11400	COG0017	Asparaginyl-tRNA synthetase
K1I37_11405	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
K1I37_11425	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
K1I37_11435	COG0402	S-adenosylhomocysteine deaminase activity
K1I37_11445	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
K1I37_11450	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
K1I37_11455	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
K1I37_11455	COG1199	ATP-dependent helicase activity
K1I37_11465	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
K1I37_11465	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
K1I37_11470	COG0438	transferase activity, transferring glycosyl groups
K1I37_11475	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
K1I37_11485	COG1694	Mazg nucleotide pyrophosphohydrolase
K1I37_11490	COG3314	Sporulation integral membrane protein YlbJ
K1I37_11495	COG1968	undecaprenyl-diphosphatase activity
K1I37_11500	COG3949	Membrane
K1I37_11505	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
K1I37_11510	COG5582	Belongs to the UPF0302 family
K1I37_11575	COG3328	transposase activity
K1I37_11580	COG0287	Prephenate dehydrogenase
K1I37_11585	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
K1I37_11590	COG0159	tryptophan synthase activity
K1I37_11595	COG0133	tryptophan synthase activity
K1I37_11600	COG0135	phosphoribosylanthranilate isomerase activity
K1I37_11605	COG0134	indole-3-glycerol-phosphate synthase activity
K1I37_11610	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
K1I37_11615	COG4401	Chorismate mutase type I
K1I37_11620	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
K1I37_11625	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
K1I37_11645	COG3547	Transposase (IS116 IS110 IS902 family)
K1I37_11660	COG0656	L-ascorbic acid biosynthetic process
K1I37_11675	COG1388	LysM domain
K1I37_11675	COG1705	Flagellar rod assembly protein muramidase FlgJ
K1I37_11680	COG4548	von Willebrand factor, type A
K1I37_11685	COG0714	Associated with various cellular activities
K1I37_11690	COG3706	GGDEF domain
K1I37_11710	COG1914	H( )-stimulated, divalent metal cation uptake system
K1I37_11715	COG0508	dehydrogenase complex catalyzes the overall conversion of
K1I37_11720	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
K1I37_11725	COG0517	IMP dehydrogenase activity
K1I37_11735	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
K1I37_11740	COG1752	Esterase of the alpha-beta hydrolase superfamily
K1I37_11745	COG0105	UTP biosynthetic process
K1I37_11750	COG0142	geranyltranstransferase activity
K1I37_11755	COG2226	methyltransferase
K1I37_11775	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
K1I37_11780	COG0509	glycine decarboxylation via glycine cleavage system
K1I37_11790	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
K1I37_11795	COG1160	GTP binding
K1I37_11810	COG0539	negative regulation of cytoplasmic translation
K1I37_11825	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
K1I37_11855	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
K1I37_11865	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
K1I37_11870	COG1609	Transcriptional regulator
K1I37_11880	COG3328	transposase activity
K1I37_11900	COG0210	DNA helicase
K1I37_11910	COG2226	methyltransferase
K1I37_11920	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
K1I37_11925	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
K1I37_11940	COG2339	peptidase activity
K1I37_11950	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
K1I37_11965	COG5002	protein histidine kinase activity
K1I37_11970	COG0745	RESPONSE REGULATOR receiver
K1I37_11980	COG1187	pseudouridine synthase activity
K1I37_11985	COG0700	Nucleoside recognition
K1I37_11990	COG2715	membrane protein required for spore maturation
K1I37_11995	COG3874	Sporulation protein YtfJ
K1I37_12005	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
K1I37_12010	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
K1I37_12015	COG1994	Peptidase M50
K1I37_12035	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
K1I37_12045	COG1191	sigma factor activity
K1I37_12050	COG2172	sigma factor antagonist activity
K1I37_12055	COG1366	Belongs to the anti-sigma-factor antagonist family
K1I37_12065	COG1686	Belongs to the peptidase S11 family
K1I37_12070	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
K1I37_12075	COG4974	Belongs to the 'phage' integrase family
K1I37_12090	COG1300	Membrane
K1I37_12095	COG1379	DNA repair
K1I37_12100	COG0494	nUDIX hydrolase
K1I37_12105	COG1113	amino acid transport
K1I37_12110	COG2195	Cleaves the N-terminal amino acid of tripeptides
K1I37_12115	COG0321	lipoyl(octanoyl) transferase activity
K1I37_12120	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
K1I37_12125	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
K1I37_12130	COG0315	cyclic pyranopterin monophosphate synthase activity
K1I37_12135	COG0314	molybdopterin synthase activity
K1I37_12165	COG3253	May function as heme-dependent peroxidase
K1I37_12180	COG1733	regulation of RNA biosynthetic process
K1I37_12190	COG0750	zinc metalloprotease
K1I37_12195	COG0497	DNA recombination
K1I37_12200	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
K1I37_12210	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
K1I37_12215	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
K1I37_12225	COG0142	geranyltranstransferase activity
K1I37_12230	COG1722	exodeoxyribonuclease VII activity
K1I37_12235	COG1570	exodeoxyribonuclease VII activity
K1I37_12240	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
K1I37_12245	COG0492	ferredoxin-NADP+ reductase activity
K1I37_12250	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
K1I37_12270	COG1302	Protein conserved in bacteria
K1I37_12275	COG0439	Biotin carboxylase
K1I37_12280	COG0511	ligase activity, forming carbon-carbon bonds
K1I37_12320	COG3854	ATPases associated with a variety of cellular activities
K1I37_12330	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
K1I37_12335	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
K1I37_12340	COG0406	alpha-ribazole phosphatase activity
K1I37_12345	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
K1I37_12350	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
K1I37_12355	COG0404	The glycine cleavage system catalyzes the degradation of glycine
K1I37_12360	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
K1I37_12370	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
K1I37_12375	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
K1I37_12400	COG2165	general secretion pathway protein
K1I37_12410	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
K1I37_12420	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
K1I37_12430	COG0211	Belongs to the bacterial ribosomal protein bL27 family
K1I37_12455	COG2894	cell division
K1I37_12460	COG0850	regulation of cytokinetic process
K1I37_12475	COG1077	Cell shape determining protein MreB Mrl
K1I37_12480	COG2003	Belongs to the UPF0758 family
K1I37_12500	COG3583	domain protein
K1I37_12500	COG3584	3D domain protein
K1I37_12505	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
K1I37_12515	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
K1I37_12520	COG0285	dihydrofolate synthase activity
K1I37_12525	COG0525	valine-tRNA ligase activity
K1I37_12545	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
K1I37_12550	COG0113	porphobilinogen synthase activity
K1I37_12560	COG0181	hydroxymethylbilane synthase activity
K1I37_12565	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
K1I37_12570	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
K1I37_12575	COG0218	Necessary for normal cell division and for the maintenance of normal septation
K1I37_12585	COG0470	DNA polymerase III
K1I37_12585	COG1067	ATP-dependent peptidase activity
K1I37_12590	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
K1I37_12600	COG0544	peptidyl-prolyl cis-trans isomerase activity
K1I37_12620	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
K1I37_12625	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
K1I37_12630	COG1846	Transcriptional regulator
K1I37_12635	COG2197	response regulator
K1I37_12640	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
K1I37_12650	COG1054	Belongs to the UPF0176 family
K1I37_12665	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
K1I37_12670	COG1053	succinate dehydrogenase
K1I37_12675	COG2009	succinate dehydrogenase
K1I37_12680	COG0322	excinuclease ABC activity
K1I37_12705	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
K1I37_12715	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
K1I37_12720	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
K1I37_12730	COG0387	Pfam Sodium calcium exchanger
K1I37_12755	COG1316	TRANSCRIPTIONal
K1I37_12760	COG0463	Glycosyl transferase, family 2
K1I37_12775	COG2084	Dehydrogenase
K1I37_12780	COG1846	Transcriptional regulator
K1I37_12800	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
K1I37_12815	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
K1I37_12820	COG2244	polysaccharide biosynthetic process
K1I37_12825	COG0671	phosphoesterase, PA-phosphatase related
K1I37_12830	COG2205	protein histidine kinase activity
K1I37_12835	COG0745	RESPONSE REGULATOR receiver
K1I37_12870	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
K1I37_12885	COG0205	6-phosphofructokinase activity
K1I37_12890	COG1064	alcohol dehydrogenase
K1I37_12895	COG1309	transcriptional regulator
K1I37_12905	COG1657	PFAM Prenyltransferase squalene oxidase
K1I37_12910	COG1309	transcriptional regulator
K1I37_12915	COG0477	Major facilitator Superfamily
K1I37_12930	COG0833	amino acid
K1I37_12935	COG3829	transcription factor binding
K1I37_12940	COG1012	belongs to the aldehyde dehydrogenase family
K1I37_12945	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
K1I37_12950	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
K1I37_12970	COG4372	Transposase
K1I37_12980	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K1I37_13010	COG0647	UMP catabolic process
K1I37_13020	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K1I37_13035	COG2076	Multidrug Resistance protein
K1I37_13040	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
K1I37_13050	COG2814	Major facilitator Superfamily
K1I37_13055	COG1846	Transcriptional regulator
K1I37_13065	COG0747	negative chemotaxis
K1I37_13100	COG0456	acetyltransferase
K1I37_13105	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
K1I37_13115	COG1388	LysM domain
K1I37_13115	COG0791	NLP P60 protein
K1I37_13120	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
K1I37_13135	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
K1I37_13155	COG0475	glutathione-regulated potassium exporter activity
K1I37_13160	COG0596	Alpha beta hydrolase
K1I37_13165	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
K1I37_13175	COG0318	PFAM AMP-dependent synthetase and ligase
K1I37_13180	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
K1I37_13185	COG1575	Belongs to the MenA family. Type 1 subfamily
K1I37_13190	COG3547	Transposase (IS116 IS110 IS902 family)
K1I37_13195	COG0598	Magnesium transport protein CorA
K1I37_13200	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
K1I37_13235	COG0667	Aldo Keto reductase
K1I37_13240	COG2207	Transcriptional regulator
K1I37_13250	COG3328	transposase activity
K1I37_13255	COG1595	DNA-templated transcription, initiation
K1I37_13270	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
K1I37_13280	COG0191	fructose-bisphosphate aldolase activity
K1I37_13285	COG1082	Xylose isomerase domain protein TIM barrel
K1I37_13290	COG1082	Xylose isomerase domain protein TIM barrel
K1I37_13295	COG0673	inositol 2-dehydrogenase activity
K1I37_13300	COG1082	Xylose isomerase domain protein TIM barrel
K1I37_13305	COG3962	Belongs to the TPP enzyme family
K1I37_13310	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K1I37_13315	COG3718	enzyme involved in inositol metabolism
K1I37_13325	COG2814	Major facilitator Superfamily
K1I37_13330	COG1349	DNA-binding transcription factor activity
K1I37_13340	COG3328	transposase activity
K1I37_13345	COG1116	anion transmembrane transporter activity
K1I37_13350	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
K1I37_13365	COG4372	Transposase
K1I37_13370	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
K1I37_13380	COG2226	methyltransferase
K1I37_13390	COG3328	transposase activity
K1I37_13415	COG2271	Major facilitator Superfamily
K1I37_13420	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
K1I37_13450	COG3328	transposase activity
K1I37_13455	COG5001	Diguanylate cyclase
K1I37_13480	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
K1I37_13540	COG0697	spore germination
K1I37_13555	COG0531	amino acid
K1I37_13570	COG0406	alpha-ribazole phosphatase activity
K1I37_13575	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
K1I37_13580	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
K1I37_13585	COG1120	ATPase activity
K1I37_13590	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K1I37_13595	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
K1I37_13600	COG0778	Nitroreductase
K1I37_13610	COG1733	regulation of RNA biosynthetic process
K1I37_13615	COG0720	synthase
K1I37_13620	COG0602	queuosine metabolic process
K1I37_13645	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
K1I37_13670	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
K1I37_13680	COG0456	acetyltransferase
K1I37_13690	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
K1I37_13695	COG1131	(ABC) transporter
K1I37_13700	COG0306	phosphate transporter
K1I37_13705	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
K1I37_13755	COG2814	Major facilitator Superfamily
K1I37_13760	COG0300	oxidoreductase activity
K1I37_13770	COG1940	carbohydrate kinase activity
K1I37_13775	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
K1I37_13780	COG2176	DNA-directed DNA polymerase activity
K1I37_13785	COG1346	cytolysis
K1I37_13800	COG2814	Major facilitator Superfamily
K1I37_13805	COG5577	PFAM Coat F domain
K1I37_13820	COG0697	spore germination
K1I37_13835	COG0456	acetyltransferase
K1I37_13835	COG1846	Transcriptional regulator
K1I37_13840	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
K1I37_13845	COG0789	Transcriptional regulator
K1I37_13850	COG1247	-acetyltransferase
K1I37_13865	COG3328	transposase activity
K1I37_13880	COG4372	Transposase
K1I37_13910	COG3409	Peptidoglycan-binding domain 1 protein
K1I37_13910	COG3267	Type II secretory pathway component ExeA
K1I37_13920	COG3328	transposase activity
K1I37_13930	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
K1I37_13935	COG1131	(ABC) transporter
K1I37_13945	COG1131	(ABC) transporter
K1I37_13950	COG1725	Transcriptional regulator
K1I37_13965	COG0431	NADPH-dependent FMN reductase
K1I37_13970	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
K1I37_13990	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K1I37_13995	COG0454	-acetyltransferase
K1I37_14000	COG2226	methyltransferase
K1I37_14005	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K1I37_14010	COG0385	Bile acid
K1I37_14020	COG0024	Methionine aminopeptidase
K1I37_14025	COG0242	peptide deformylase activity
K1I37_14030	COG4106	trans-aconitate 2-methyltransferase activity
K1I37_14055	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
K1I37_14070	COG1414	Transcriptional regulator
K1I37_14085	COG1414	Transcriptional regulator
K1I37_14090	COG2814	Major facilitator Superfamily
K1I37_14095	COG0454	-acetyltransferase
K1I37_14135	COG1121	(ABC) transporter
K1I37_14150	COG0523	cobalamin synthesis protein
K1I37_14155	COG0735	belongs to the Fur family
K1I37_14170	COG0488	(ABC) transporter
K1I37_14175	COG0488	(ABC) transporter
K1I37_14195	COG0069	glutamate synthase activity
K1I37_14240	COG0395	ABC-type sugar transport system, permease component
K1I37_14245	COG1175	transmembrane transport
K1I37_14260	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
K1I37_14285	COG2814	Major facilitator Superfamily
K1I37_14290	COG3328	transposase activity
K1I37_14305	COG0840	transmembrane signaling receptor activity
K1I37_14310	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
K1I37_14335	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
K1I37_14340	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
K1I37_14350	COG0747	negative chemotaxis
K1I37_14360	COG0425	Belongs to the sulfur carrier protein TusA family
K1I37_14365	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K1I37_14365	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
K1I37_14370	COG2210	Belongs to the sulfur carrier protein TusA family
K1I37_14380	COG1937	Protein conserved in bacteria
K1I37_14390	COG1335	isochorismatase
K1I37_14400	COG0517	IMP dehydrogenase activity
K1I37_14410	COG2814	Major facilitator Superfamily
K1I37_14420	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
K1I37_14430	COG1028	Short-chain dehydrogenase reductase Sdr
K1I37_14435	COG3328	transposase activity
K1I37_14460	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
K1I37_14465	COG1846	Transcriptional regulator
K1I37_14490	COG3328	transposase activity
K1I37_14500	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
K1I37_14505	COG2384	SAM-dependent methyltransferase
K1I37_14515	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
K1I37_14520	COG0358	DNA primase activity
K1I37_14525	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
K1I37_14540	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
K1I37_14550	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
K1I37_14555	COG1480	7TM receptor with intracellular HD hydrolase
K1I37_14560	COG1702	phosphate starvation-inducible protein PhoH
K1I37_14575	COG1610	YqeY-like protein
K1I37_14580	COG0828	Belongs to the bacterial ribosomal protein bS21 family
K1I37_14585	COG1283	sodium-dependent phosphate transmembrane transporter activity
K1I37_14590	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
K1I37_14595	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
K1I37_14600	COG1385	rRNA (uridine-N3-)-methyltransferase activity
K1I37_14605	COG2264	protein methyltransferase activity
K1I37_14615	COG0443	Heat shock 70 kDa protein
K1I37_14620	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
K1I37_14625	COG1420	regulation of RNA biosynthetic process
K1I37_14630	COG0635	Involved in the biosynthesis of porphyrin-containing compound
K1I37_14635	COG0481	GTPase activity
K1I37_14650	COG1196	nuclear chromosome segregation
K1I37_14650	COG0739	heme binding
K1I37_14650	COG0741	lytic transglycosylase activity
K1I37_14655	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
K1I37_14660	COG0268	Binds directly to 16S ribosomal RNA
K1I37_14670	COG1466	dna polymerase III delta subunit
K1I37_14675	COG1252	NADH dehydrogenase
K1I37_14690	COG1321	iron dependent repressor
K1I37_14695	COG2226	methyltransferase
K1I37_14700	COG0799	negative regulation of ribosome biogenesis
K1I37_14705	COG1713	HD superfamily hydrolase involved in NAD metabolism
K1I37_14710	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
K1I37_14715	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
K1I37_14720	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
K1I37_14725	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
K1I37_14735	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
K1I37_14775	COG3584	3D domain protein
K1I37_14775	COG1388	LysM domain
K1I37_14815	COG0756	dUTP diphosphatase activity
K1I37_15000	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
K1I37_15120	COG0270	DNA (cytosine-5-)-methyltransferase activity
K1I37_15215	COG0739	heme binding
K1I37_15245	COG0740	serine-type endopeptidase activity
K1I37_15360	COG0393	Putative heavy-metal-binding
K1I37_15370	COG1705	Flagellar rod assembly protein muramidase FlgJ
K1I37_15370	COG1388	LysM domain
K1I37_15465	COG0768	penicillin binding
K1I37_15470	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
K1I37_15475	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
K1I37_15480	COG4472	Bacterial protein of unknown function (DUF965)
K1I37_15495	COG0628	permease
K1I37_15500	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
K1I37_15505	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
K1I37_15515	COG1104	cysteine desulfurase activity
K1I37_15520	COG1959	2 iron, 2 sulfur cluster binding
K1I37_15530	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
K1I37_15535	COG0124	histidyl-tRNA synthetase
K1I37_15550	COG4405	Protein conserved in bacteria
K1I37_15555	COG0833	amino acid
K1I37_15560	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K1I37_15565	COG1846	Transcriptional regulator
K1I37_15570	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
K1I37_15575	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
K1I37_15580	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
K1I37_15580	COG4499	WXG100 protein secretion system (Wss), protein YukC
K1I37_15585	COG0028	Belongs to the TPP enzyme family
K1I37_15590	COG1595	DNA-templated transcription, initiation
K1I37_15625	COG0477	Major facilitator Superfamily
K1I37_15630	COG0583	DNA-binding transcription factor activity
K1I37_15635	COG0386	Belongs to the glutathione peroxidase family
K1I37_15640	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
K1I37_15655	COG0517	IMP dehydrogenase activity
K1I37_15660	COG0574	Belongs to the PEP-utilizing enzyme family
K1I37_15660	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
K1I37_15665	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
K1I37_15670	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
K1I37_15705	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
K1I37_15715	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
K1I37_15715	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
K1I37_15720	COG0039	L-malate dehydrogenase activity
K1I37_15725	COG1250	3-hydroxyacyl-CoA dehydrogenase
K1I37_15740	COG1028	Short-chain dehydrogenase reductase Sdr
K1I37_15755	COG0667	Aldo Keto reductase
K1I37_15760	COG0303	'Molybdopterin
K1I37_15770	COG1210	Utp--glucose-1-phosphate uridylyltransferase
K1I37_15775	COG1074	ATP-dependent DNA helicase activity
K1I37_15780	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
K1I37_15785	COG4717	serine-type aminopeptidase activity
K1I37_15795	COG0477	Major facilitator Superfamily
K1I37_15815	COG3239	Fatty acid desaturase
K1I37_15820	COG1278	Cold shock
K1I37_15835	COG1028	Short-chain dehydrogenase reductase Sdr
K1I37_15840	COG2814	Major facilitator Superfamily
K1I37_15845	COG4191	Histidine kinase
K1I37_15850	COG3547	Transposase (IS116 IS110 IS902 family)
K1I37_15900	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
K1I37_15905	COG0477	Major facilitator Superfamily
K1I37_15920	COG0681	Belongs to the peptidase S26 family
K1I37_15925	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
K1I37_15935	COG1686	Belongs to the peptidase S11 family
K1I37_15955	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
K1I37_15960	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
K1I37_15965	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
K1I37_15980	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K1I37_15995	COG5001	Diguanylate cyclase
K1I37_16010	COG1490	D-aminoacyl-tRNA deacylase activity
K1I37_16015	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
K1I37_16020	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
K1I37_16025	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
K1I37_16025	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
K1I37_16030	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
K1I37_16035	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
K1I37_16040	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
K1I37_16050	COG2244	polysaccharide biosynthetic process
K1I37_16055	COG2323	membrane
K1I37_16075	COG0343	queuine tRNA-ribosyltransferase activity
K1I37_16080	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
K1I37_16100	COG3693	PFAM glycoside hydrolase, family 10
K1I37_16105	COG1191	sigma factor activity
K1I37_16110	COG2255	four-way junction helicase activity
K1I37_16115	COG0632	four-way junction helicase activity
K1I37_16120	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
K1I37_16130	COG0217	transcriptional regulatory protein
K1I37_16165	COG4499	WXG100 protein secretion system (Wss), protein YukC
K1I37_16165	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
K1I37_16170	COG1028	Short-chain dehydrogenase reductase Sdr
K1I37_16175	COG1193	negative regulation of DNA recombination
K1I37_16190	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
K1I37_16195	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K1I37_16195	COG0072	phenylalanine-tRNA ligase activity
K1I37_16200	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
K1I37_16215	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K1I37_16220	COG0601	transmembrane transport
K1I37_16235	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
K1I37_16240	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
K1I37_16245	COG1830	Aldolase
K1I37_16250	COG0205	6-phosphofructokinase activity
K1I37_16255	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
K1I37_16260	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
K1I37_16265	COG3842	ATPase activity
K1I37_16270	COG3835	regulator
K1I37_16285	COG0584	glycerophosphoryl diester phosphodiesterase
K1I37_16290	COG0508	dehydrogenase complex catalyzes the overall conversion of
K1I37_16295	COG0567	Dehydrogenase, E1 component
K1I37_16305	COG0714	Associated with various cellular activities
K1I37_16320	COG1482	cell wall glycoprotein biosynthetic process
K1I37_16325	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
K1I37_16335	COG0673	inositol 2-dehydrogenase activity
K1I37_16340	COG0673	inositol 2-dehydrogenase activity
K1I37_16345	COG1082	Xylose isomerase domain protein TIM barrel
K1I37_16355	COG1082	Xylose isomerase domain protein TIM barrel
K1I37_16355	COG3185	4-Hydroxyphenylpyruvate dioxygenase
K1I37_16365	COG3546	catalase activity
K1I37_16380	COG3344	reverse transcriptase
K1I37_16385	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
K1I37_16395	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
K1I37_16400	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
K1I37_16405	COG0291	Belongs to the bacterial ribosomal protein bL35 family
K1I37_16410	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
K1I37_16415	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
K1I37_16435	COG2814	Major facilitator Superfamily
K1I37_16440	COG1846	Transcriptional regulator
K1I37_16445	COG3328	transposase activity
K1I37_16515	COG0739	heme binding
K1I37_16565	COG3239	Fatty acid desaturase
K1I37_16570	COG1278	Cold shock
K1I37_16595	COG4372	Transposase
K1I37_16615	COG5002	protein histidine kinase activity
K1I37_16625	COG1388	LysM domain
K1I37_16635	COG1819	glycosyl
K1I37_16650	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
K1I37_16680	COG3328	transposase activity
K1I37_16700	COG1376	ErfK ybiS ycfS ynhG family protein
K1I37_16740	COG0840	transmembrane signaling receptor activity
K1I37_16750	COG0604	alcohol dehydrogenase
K1I37_16755	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
K1I37_16790	COG1278	Cold shock
K1I37_16815	COG1278	Cold shock
K1I37_16830	COG1028	Short-chain dehydrogenase reductase Sdr
K1I37_16850	COG2151	metal-sulfur cluster biosynthetic enzyme
K1I37_16890	COG5577	PFAM Coat F domain
K1I37_16895	COG2814	Major facilitator Superfamily
K1I37_16905	COG2267	carboxylic ester hydrolase activity
K1I37_16955	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
K1I37_16965	COG0438	transferase activity, transferring glycosyl groups
K1I37_16975	COG0501	Belongs to the peptidase M48B family
K1I37_16980	COG0577	efflux transmembrane transporter activity
K1I37_16985	COG1136	(ABC) transporter
K1I37_17005	COG0517	IMP dehydrogenase activity
K1I37_17020	COG0372	Belongs to the citrate synthase family
K1I37_17025	COG1971	Probably functions as a manganese efflux pump
K1I37_17030	COG0285	dihydrofolate synthase activity
K1I37_17035	COG0066	3-isopropylmalate dehydratase activity
K1I37_17040	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
K1I37_17045	COG0473	3-isopropylmalate dehydrogenase activity
K1I37_17050	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
K1I37_17055	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
K1I37_17060	COG0440	acetolactate synthase activity
K1I37_17065	COG0028	Belongs to the TPP enzyme family
K1I37_17070	COG0129	dihydroxy-acid dehydratase activity
K1I37_17075	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
K1I37_17080	COG0460	homoserine dehydrogenase
K1I37_17085	COG1607	acyl-coa hydrolase
K1I37_17090	COG0745	RESPONSE REGULATOR receiver
K1I37_17095	COG1959	2 iron, 2 sulfur cluster binding
K1I37_17100	COG1017	nitric oxide dioxygenase activity
K1I37_17100	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
K1I37_17115	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
K1I37_17120	COG0352	thiamine-phosphate diphosphorylase activity
K1I37_17120	COG0351	phosphomethylpyrimidine kinase
K1I37_17150	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
K1I37_17155	COG2217	Heavy metal translocating P-type atpase
K1I37_17160	COG1937	Protein conserved in bacteria
K1I37_17165	COG2608	mercury ion transmembrane transporter activity
K1I37_17170	COG0671	phosphoesterase, PA-phosphatase related
K1I37_17190	COG1595	DNA-templated transcription, initiation
K1I37_17195	COG1388	LysM domain
K1I37_17195	COG3858	chitin binding
K1I37_17210	COG1132	(ABC) transporter
K1I37_17215	COG1132	(ABC) transporter
K1I37_17220	COG1757	Na H antiporter
K1I37_17230	COG2814	Major facilitator Superfamily
K1I37_17235	COG2814	Major facilitator Superfamily
K1I37_17240	COG0745	RESPONSE REGULATOR receiver
K1I37_17245	COG5002	protein histidine kinase activity
K1I37_17250	COG0095	Lipoate-protein ligase
K1I37_17255	COG0583	DNA-binding transcription factor activity
K1I37_17265	COG2132	Multicopper oxidase
K1I37_17280	COG2390	Transcriptional regulator
K1I37_17295	COG1072	(Pantothenic acid kinase))
K1I37_17335	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
K1I37_17340	COG3619	membrane
K1I37_17345	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K1I37_17360	COG1802	Transcriptional regulator
K1I37_17365	COG1069	ribulokinase activity
K1I37_17375	COG2814	Major facilitator Superfamily
K1I37_17390	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
K1I37_17395	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
K1I37_17400	COG1879	ABC-type sugar transport system periplasmic component
K1I37_17405	COG1172	Belongs to the binding-protein-dependent transport system permease family
K1I37_17415	COG1869	D-ribose catabolic process
K1I37_17420	COG1609	Transcriptional regulator
K1I37_17425	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K1I37_17430	COG0402	S-adenosylhomocysteine deaminase activity
K1I37_17435	COG2195	Cleaves the N-terminal amino acid of tripeptides
K1I37_17440	COG1028	Short-chain dehydrogenase reductase Sdr
K1I37_17450	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
K1I37_17460	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
K1I37_17465	COG3829	transcription factor binding
K1I37_17465	COG3290	protein histidine kinase activity
K1I37_17475	COG1012	belongs to the aldehyde dehydrogenase family
K1I37_17480	COG1454	alcohol dehydrogenase
K1I37_17490	COG1228	amidohydrolase
K1I37_17500	COG4821	SIS domain
K1I37_17520	COG3716	PTS system mannose fructose sorbose family IID component
K1I37_17530	COG2188	Transcriptional regulator
K1I37_17535	COG0604	alcohol dehydrogenase
K1I37_17540	COG1929	Belongs to the glycerate kinase type-1 family
K1I37_17555	COG1028	Short-chain dehydrogenase reductase Sdr
K1I37_17565	COG0183	Belongs to the thiolase family
K1I37_17590	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
K1I37_17610	COG1228	amidohydrolase
K1I37_17615	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
K1I37_17665	COG2271	Major facilitator Superfamily
K1I37_17680	COG0662	Cupin 2, conserved barrel domain protein
K1I37_17700	COG4372	Transposase
K1I37_17710	COG0531	amino acid
K1I37_17715	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
K1I37_17720	COG3153	acetyltransferase
K1I37_17720	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
K1I37_17725	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
K1I37_17735	COG3290	protein histidine kinase activity
K1I37_17735	COG3829	transcription factor binding
K1I37_17740	COG1012	belongs to the aldehyde dehydrogenase family
K1I37_17750	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
K1I37_17755	COG0686	Belongs to the AlaDH PNT family
K1I37_17775	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
K1I37_17780	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
K1I37_17785	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
K1I37_17790	COG2079	MmgE PrpD family protein
K1I37_17795	COG2814	Major facilitator Superfamily
K1I37_17805	COG1804	L-carnitine dehydratase bile acid-inducible protein F
K1I37_17810	COG1414	Transcriptional regulator
K1I37_17820	COG1063	alcohol dehydrogenase
K1I37_17835	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
K1I37_17845	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
K1I37_17860	COG1335	isochorismatase
K1I37_17865	COG0673	inositol 2-dehydrogenase activity
K1I37_17875	COG0395	ABC-type sugar transport system, permease component
K1I37_17880	COG1175	transmembrane transport
K1I37_17895	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
K1I37_17905	COG1349	DNA-binding transcription factor activity
K1I37_17920	COG1472	Belongs to the glycosyl hydrolase 3 family
K1I37_17925	COG0395	ABC-type sugar transport system, permease component
K1I37_17955	COG3385	transposase activity
K1I37_17960	COG1253	flavin adenine dinucleotide binding
K1I37_17975	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
K1I37_17980	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
K1I37_17995	COG0768	penicillin binding
K1I37_18000	COG0776	regulation of translation
K1I37_18045	COG2259	Doxx family
K1I37_18050	COG1063	alcohol dehydrogenase
K1I37_18055	COG1940	carbohydrate kinase activity
K1I37_18070	COG2207	Transcriptional regulator
K1I37_18080	COG0531	amino acid
K1I37_18095	COG0741	lytic transglycosylase activity
K1I37_18100	COG0237	dephospho-CoA kinase activity
K1I37_18110	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
K1I37_18110	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
K1I37_18120	COG0538	isocitrate dehydrogenase activity
K1I37_18130	COG0745	RESPONSE REGULATOR receiver
K1I37_18135	COG0180	Tryptophanyl-tRNA synthetase
K1I37_18145	COG0825	malonyl-CoA metabolic process
K1I37_18150	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
K1I37_18160	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
K1I37_18165	COG0587	DNA-directed DNA polymerase activity
K1I37_18170	COG4109	DRTGG domain
K1I37_18175	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
K1I37_18195	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
K1I37_18200	COG1438	arginine binding
K1I37_18205	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
K1I37_18220	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
K1I37_18225	COG3679	Belongs to the UPF0342 family
K1I37_18230	COG2346	COG2346, Truncated hemoglobins
K1I37_18240	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
K1I37_18245	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
K1I37_18265	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
K1I37_18275	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
K1I37_18275	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
K1I37_18285	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
K1I37_18285	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
K1I37_18290	COG1045	serine acetyltransferase
K1I37_18305	COG4496	protein, YerC YecD
K1I37_18340	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
K1I37_18355	COG5002	protein histidine kinase activity
K1I37_18360	COG0745	RESPONSE REGULATOR receiver
K1I37_18365	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
K1I37_18375	COG0805	protein transport
K1I37_18380	COG2271	Major facilitator Superfamily
K1I37_18385	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
K1I37_18390	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
K1I37_18400	COG3328	transposase activity
K1I37_18405	COG3290	protein histidine kinase activity
K1I37_18405	COG3829	transcription factor binding
K1I37_18420	COG0517	IMP dehydrogenase activity
K1I37_18420	COG1125	glycine betaine transport
K1I37_18425	COG1063	alcohol dehydrogenase
K1I37_18430	COG1960	acyl-CoA dehydrogenase activity
K1I37_18440	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
K1I37_18450	COG1902	pentaerythritol trinitrate reductase activity
K1I37_18450	COG0446	pyridine nucleotide-disulphide oxidoreductase
K1I37_18455	COG0318	PFAM AMP-dependent synthetase and ligase
K1I37_18465	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
K1I37_18490	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
K1I37_18495	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K1I37_18505	COG3386	PFAM SMP-30 Gluconolaconase
K1I37_18515	COG1657	PFAM Prenyltransferase squalene oxidase
K1I37_18530	COG1846	Transcriptional regulator
K1I37_18535	COG0477	Major facilitator Superfamily
K1I37_18540	COG0655	NAD(P)H dehydrogenase (quinone) activity
K1I37_18545	COG2814	Major facilitator Superfamily
K1I37_18555	COG1028	Short-chain dehydrogenase reductase Sdr
K1I37_18565	COG1028	Short-chain dehydrogenase reductase Sdr
K1I37_18570	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
K1I37_18590	COG0667	Aldo Keto reductase
K1I37_18620	COG0788	formyltetrahydrofolate deformylase activity
K1I37_18640	COG1587	Uroporphyrinogen-III synthase
K1I37_18640	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
K1I37_18645	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
K1I37_18650	COG0175	sulfate reduction
K1I37_18655	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
K1I37_18655	COG1648	precorrin-2 dehydrogenase activity
K1I37_18660	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
K1I37_18660	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
K1I37_18670	COG0655	NAD(P)H dehydrogenase (quinone) activity
K1I37_18675	COG2814	Major facilitator Superfamily
K1I37_18680	COG1566	PFAM secretion protein HlyD family protein
K1I37_18685	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
K1I37_18695	COG1376	ErfK ybiS ycfS ynhG family protein
K1I37_18700	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
K1I37_18700	COG2755	lipolytic protein G-D-S-L family
K1I37_18710	COG1164	Oligoendopeptidase f
K1I37_18715	COG0445	tRNA wobble uridine modification
K1I37_18730	COG1216	Glycosyl transferase, family 2
K1I37_18735	COG2814	Major facilitator Superfamily
K1I37_18740	COG1233	COG1233 Phytoene dehydrogenase and related
K1I37_18750	COG1562	ergosterol biosynthetic process
K1I37_18755	COG1657	PFAM Prenyltransferase squalene oxidase
K1I37_18760	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
K1I37_18775	COG1304	FMN binding
K1I37_18780	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
K1I37_18790	COG3135	benzoate transporter
K1I37_18795	COG0583	DNA-binding transcription factor activity
K1I37_18800	COG0163	prenyltransferase activity
K1I37_18805	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
K1I37_18825	COG0514	ATP-dependent DNA helicase (RecQ)
K1I37_18850	COG1388	LysM domain
K1I37_18850	COG3858	chitin binding
K1I37_18855	COG3328	transposase activity
K1I37_18860	COG0697	spore germination
K1I37_18865	COG1902	pentaerythritol trinitrate reductase activity
K1I37_18870	COG1012	belongs to the aldehyde dehydrogenase family
K1I37_18880	COG2814	Major facilitator Superfamily
K1I37_18885	COG0363	glucosamine-6-phosphate deaminase activity
K1I37_18890	COG0531	amino acid
K1I37_18935	COG0517	IMP dehydrogenase activity
K1I37_18935	COG1125	glycine betaine transport
K1I37_18950	COG4336	lyase activity
K1I37_18960	COG1914	H( )-stimulated, divalent metal cation uptake system
K1I37_19005	COG4372	Transposase
K1I37_19030	COG1012	belongs to the aldehyde dehydrogenase family
K1I37_19035	COG0183	Belongs to the thiolase family
K1I37_19040	COG1250	3-hydroxyacyl-CoA dehydrogenase
K1I37_19045	COG1250	3-hydroxyacyl-CoA dehydrogenase
K1I37_19050	COG1024	Enoyl-CoA hydratase
K1I37_19065	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
K1I37_19070	COG2151	metal-sulfur cluster biosynthetic enzyme
K1I37_19085	COG1024	Enoyl-CoA hydratase
K1I37_19090	COG3396	Phenylacetate-CoA oxygenase
K1I37_19095	COG1309	transcriptional regulator
K1I37_19100	COG3328	transposase activity
K1I37_19110	COG1476	TRANSCRIPTIONal
K1I37_19125	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
K1I37_19160	COG4372	Transposase
K1I37_19190	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
K1I37_19195	COG1984	allophanate hydrolase subunit 2
K1I37_19200	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
K1I37_19205	COG1028	Short-chain dehydrogenase reductase Sdr
K1I37_19210	COG1312	Catalyzes the dehydration of D-mannonate
K1I37_19215	COG0800	Aldolase
K1I37_19220	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K1I37_19225	COG2814	Major facilitator Superfamily
K1I37_19245	COG0395	ABC-type sugar transport system, permease component
K1I37_19250	COG1175	transmembrane transport
K1I37_19270	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
K1I37_19290	COG0436	Aminotransferase
K1I37_19295	COG1846	Transcriptional regulator
K1I37_19300	COG1764	response to oxidative stress
K1I37_19355	COG0583	DNA-binding transcription factor activity
K1I37_19365	COG3328	transposase activity
K1I37_19375	COG0747	negative chemotaxis
K1I37_19380	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
K1I37_19385	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
K1I37_19390	COG1780	Probably involved in ribonucleotide reductase function
K1I37_19395	COG3384	dioxygenase
K1I37_19400	COG0655	NAD(P)H dehydrogenase (quinone) activity
K1I37_19435	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
K1I37_19445	COG0577	efflux transmembrane transporter activity
K1I37_19460	COG5002	protein histidine kinase activity
K1I37_19465	COG0745	RESPONSE REGULATOR receiver
K1I37_19475	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
K1I37_19485	COG0653	protein targeting
K1I37_19490	COG1215	transferase activity, transferring glycosyl groups
K1I37_19510	COG1516	flagellar protein fliS
K1I37_19520	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
K1I37_19530	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K1I37_19535	COG1256	bacterial-type flagellum assembly
K1I37_19535	COG4786	Flagellar basal body rod
K1I37_19565	COG5002	protein histidine kinase activity
K1I37_19570	COG0745	RESPONSE REGULATOR receiver
K1I37_19590	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
K1I37_19595	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
K1I37_19610	COG2814	Major facilitator Superfamily
K1I37_19615	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
K1I37_19620	COG0412	Dienelactone hydrolase
K1I37_19625	COG0521	Mo-molybdopterin cofactor biosynthetic process
K1I37_19625	COG0315	cyclic pyranopterin monophosphate synthase activity
K1I37_19630	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
K1I37_19655	COG1609	Transcriptional regulator
K1I37_19675	COG2160	L-arabinose isomerase activity
K1I37_19695	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
K1I37_19775	COG0384	phenazine biosynthesis protein PhzF
K1I37_19780	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
K1I37_19790	COG1187	pseudouridine synthase activity
K1I37_19795	COG2258	MOSC domain
K1I37_19815	COG4608	Belongs to the ABC transporter superfamily
K1I37_19840	COG1609	Transcriptional regulator
K1I37_19845	COG2723	6-phospho-beta-galactosidase activity
K1I37_19850	COG4608	Belongs to the ABC transporter superfamily
K1I37_19875	COG1609	Transcriptional regulator
K1I37_19880	COG0306	phosphate transporter
K1I37_19885	COG1392	Phosphate transport regulator
K1I37_19890	COG0833	amino acid
K1I37_19900	COG0667	Aldo Keto reductase
K1I37_19915	COG1113	amino acid transport
K1I37_19920	COG2188	Transcriptional regulator
K1I37_19930	COG0318	PFAM AMP-dependent synthetase and ligase
K1I37_19935	COG2814	Major facilitator Superfamily
K1I37_19950	COG1809	phosphosulfolactate synthase activity
K1I37_19960	COG0531	amino acid
K1I37_19965	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
K1I37_19970	COG0400	carboxylic ester hydrolase activity
K1I37_19980	COG1793	dna ligase
K1I37_19985	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K1I37_19990	COG3285	dna ligase
K1I37_19990	COG1793	dna ligase
K1I37_20000	COG0488	(ABC) transporter
K1I37_20005	COG4895	conserved protein (DUF2196)
K1I37_20030	COG2076	Multidrug Resistance protein
K1I37_20050	COG0395	ABC-type sugar transport system, permease component
K1I37_20060	COG0584	glycerophosphoryl diester phosphodiesterase
K1I37_20080	COG1227	inorganic diphosphatase activity
K1I37_20090	COG1388	LysM domain
K1I37_20090	COG1705	Flagellar rod assembly protein muramidase FlgJ
K1I37_20250	COG1132	(ABC) transporter
K1I37_20255	COG1132	(ABC) transporter
K1I37_20260	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
K1I37_20265	COG0561	phosphatase activity
K1I37_20270	COG2720	vancomycin resistance protein
K1I37_20290	COG1733	regulation of RNA biosynthetic process
K1I37_20295	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
K1I37_20300	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
K1I37_20305	COG1012	belongs to the aldehyde dehydrogenase family
K1I37_20315	COG0166	Belongs to the GPI family
K1I37_20325	COG4191	Histidine kinase
K1I37_20355	COG0745	RESPONSE REGULATOR receiver
K1I37_20360	COG2205	protein histidine kinase activity
K1I37_20370	COG2814	Major facilitator Superfamily
K1I37_20375	COG1733	regulation of RNA biosynthetic process
K1I37_20395	COG4585	Histidine kinase
K1I37_20400	COG2197	response regulator
K1I37_20420	COG1028	Short-chain dehydrogenase reductase Sdr
K1I37_20425	COG0789	Transcriptional regulator
K1I37_20430	COG5609	conserved protein (DUF2294)
K1I37_20435	COG3002	Belongs to the UPF0753 family
K1I37_20440	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
K1I37_20450	COG4372	Transposase
K1I37_20485	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K1I37_20490	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K1I37_20500	COG3547	Transposase (IS116 IS110 IS902 family)
K1I37_20515	COG1120	ATPase activity
K1I37_20525	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
K1I37_20530	COG0246	Mannitol dehydrogenase
K1I37_20540	COG3711	transcriptional antiterminator
K1I37_20545	COG2213	PTS system mannitol-specific
K1I37_20560	COG5002	protein histidine kinase activity
K1I37_20565	COG2814	Major facilitator Superfamily
K1I37_20605	COG1476	TRANSCRIPTIONal
K1I37_20610	COG3409	Peptidoglycan-binding domain 1 protein
K1I37_20610	COG3267	Type II secretory pathway component ExeA
K1I37_20635	COG3328	transposase activity
K1I37_20670	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
K1I37_20685	COG4372	Transposase
K1I37_20695	COG0653	protein targeting
K1I37_20705	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
K1I37_20710	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
K1I37_20715	COG0321	lipoyl(octanoyl) transferase activity
K1I37_20715	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
K1I37_20730	COG5002	protein histidine kinase activity
K1I37_20745	COG0305	Participates in initiation and elongation during chromosome replication
K1I37_20750	COG0359	binds to the 23S rRNA
K1I37_20765	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
K1I37_20770	COG0629	single-stranded DNA binding
K1I37_20780	COG0012	GTP binding
K1I37_20785	COG0243	molybdopterin cofactor binding
K1I37_20790	COG4481	Protein conserved in bacteria
K1I37_20795	COG0668	transmembrane transport
K1I37_20815	COG1811	Na channel or pump
K1I37_20820	COG1475	DNA binding
K1I37_20825	COG1192	Involved in chromosome partitioning
K1I37_20830	COG1475	DNA binding
K1I37_20835	COG0357	Ribosomal RNA small subunit methyltransferase G
K1I37_20840	COG0445	tRNA wobble uridine modification
K1I37_20845	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
K1I37_20850	COG1847	R3H domain protein
K1I37_20855	COG0706	membrane insertase activity
K1I37_20860	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
K1I37_20870	COG0230	Belongs to the bacterial ribosomal protein bL34 family
K1I37_20925	COG2002	toxin-antitoxin pair type II binding
K1I37_20935	COG0629	single-stranded DNA binding
K1I37_20985	COG0592	DNA-directed DNA polymerase activity
K1I37_21070	COG1061	Type III restriction enzyme res subunit
K1I37_21090	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
K1I37_21105	COG3547	Transposase (IS116 IS110 IS902 family)
K1I37_21150	COG1192	Involved in chromosome partitioning
K1I37_21175	COG2200	EAL domain
K1I37_21240	COG3328	transposase activity
K1I37_21245	COG3547	Transposase (IS116 IS110 IS902 family)
K1I37_21250	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
K1I37_21265	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
K1I37_21265	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
K1I37_21290	COG0210	DNA helicase
K1I37_21310	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
K1I37_21390	COG0697	spore germination
K1I37_21400	COG4221	oxidoreductase activity
K1I37_21405	COG3328	transposase activity
K1I37_21435	COG4962	Type ii secretion system protein e