locus-tag	class	description
K3X53_00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
K3X53_00040	COG3909	cytochrome
K3X53_00045	COG1529	Aldehyde oxidase and xanthine dehydrogenase
K3X53_00045	COG2010	Cytochrome c
K3X53_00050	COG2132	Multicopper oxidase
K3X53_00075	COG0010	Belongs to the arginase family
K3X53_00080	COG1166	arginine decarboxylase activity
K3X53_00095	COG0010	Belongs to the arginase family
K3X53_00100	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
K3X53_00115	COG2022	thiamine diphosphate biosynthetic process
K3X53_00125	COG0351	phosphomethylpyrimidine kinase
K3X53_00135	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
K3X53_00150	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
K3X53_00155	COG3938	Belongs to the proline racemase family
K3X53_00160	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K3X53_00165	COG3938	Belongs to the proline racemase family
K3X53_00170	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
K3X53_00175	COG1802	Transcriptional regulator
K3X53_00185	COG0028	Belongs to the TPP enzyme family
K3X53_00190	COG1349	DNA-binding transcription factor activity
K3X53_00205	COG1840	ABC-type Fe3 transport system, periplasmic component
K3X53_00210	COG3842	ATPase activity
K3X53_00225	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
K3X53_00235	COG1012	belongs to the aldehyde dehydrogenase family
K3X53_00250	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
K3X53_00270	COG1283	sodium-dependent phosphate transmembrane transporter activity
K3X53_00290	COG0745	RESPONSE REGULATOR receiver
K3X53_00295	COG2205	protein histidine kinase activity
K3X53_00305	COG1120	ATPase activity
K3X53_00315	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K3X53_00320	COG0583	DNA-binding transcription factor activity
K3X53_00370	COG1132	(ABC) transporter
K3X53_00375	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K3X53_00380	COG1804	L-carnitine dehydratase bile acid-inducible protein F
K3X53_00385	COG1960	acyl-CoA dehydrogenase activity
K3X53_00390	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K3X53_00410	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
K3X53_00415	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
K3X53_00420	COG1335	isochorismatase
K3X53_00430	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
K3X53_00440	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
K3X53_00450	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
K3X53_00470	COG0514	ATP-dependent DNA helicase (RecQ)
K3X53_00475	COG3022	response to hydroperoxide
K3X53_00500	COG1028	Short-chain dehydrogenase reductase Sdr
K3X53_00500	COG0604	alcohol dehydrogenase
K3X53_00500	COG3321	synthase
K3X53_00510	COG0828	Belongs to the bacterial ribosomal protein bS21 family
K3X53_00515	COG2814	Major facilitator Superfamily
K3X53_00525	COG2267	carboxylic ester hydrolase activity
K3X53_00535	COG2423	ornithine cyclodeaminase activity
K3X53_00560	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
K3X53_00640	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
K3X53_00650	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
K3X53_00650	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K3X53_00655	COG0697	spore germination
K3X53_00660	COG0741	lytic transglycosylase activity
K3X53_00665	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
K3X53_00675	COG1720	tRNA m6t6A37 methyltransferase activity
K3X53_00680	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
K3X53_00685	COG0303	'Molybdopterin
K3X53_00690	COG0746	molybdenum cofactor guanylyltransferase activity
K3X53_00695	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
K3X53_00710	COG0583	DNA-binding transcription factor activity
K3X53_00750	COG1960	acyl-CoA dehydrogenase activity
K3X53_00755	COG0009	L-threonylcarbamoyladenylate synthase
K3X53_00760	COG1678	Uncharacterized ACR, COG1678
K3X53_00795	COG3119	arylsulfatase activity
K3X53_00850	COG3034	peptidoglycan biosynthetic process
K3X53_00855	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
K3X53_00870	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
K3X53_00885	COG0328	RNA-DNA hybrid ribonuclease activity
K3X53_00895	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
K3X53_00905	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
K3X53_00910	COG1758	RNA polymerase activity
K3X53_00915	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
K3X53_00925	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
K3X53_00930	COG1280	lysine exporter protein (LysE YggA)
K3X53_00935	COG0736	holo-[acyl-carrier-protein] synthase activity
K3X53_00940	COG0681	Belongs to the peptidase S26 family
K3X53_00945	COG0571	ribonuclease III activity
K3X53_00950	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
K3X53_00960	COG1381	Involved in DNA repair and RecF pathway recombination
K3X53_01000	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
K3X53_01005	COG0745	RESPONSE REGULATOR receiver
K3X53_01010	COG2205	protein histidine kinase activity
K3X53_01020	COG1660	Displays ATPase and GTPase activities
K3X53_01030	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
K3X53_01040	COG0840	transmembrane signaling receptor activity
K3X53_01075	COG0300	oxidoreductase activity
K3X53_01085	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
K3X53_01095	COG0501	Belongs to the peptidase M48B family
K3X53_01100	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
K3X53_01115	COG0250	Participates in transcription elongation, termination and antitermination
K3X53_01120	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
K3X53_01125	COG0081	regulation of translation
K3X53_01130	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
K3X53_01135	COG0222	ribosome binding
K3X53_01140	COG0085	RNA polymerase activity
K3X53_01145	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
K3X53_01155	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
K3X53_01160	COG0049	tRNA binding
K3X53_01165	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
K3X53_01170	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
K3X53_01185	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
K3X53_01190	COG0088	Forms part of the polypeptide exit tunnel
K3X53_01195	COG0089	rRNA binding
K3X53_01205	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
K3X53_01210	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
K3X53_01215	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
K3X53_01220	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
K3X53_01225	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
K3X53_01250	COG0255	Belongs to the universal ribosomal protein uL29 family
K3X53_01255	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
K3X53_01260	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
K3X53_01265	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
K3X53_01270	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
K3X53_01275	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
K3X53_01280	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
K3X53_01285	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
K3X53_01290	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
K3X53_01295	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
K3X53_01300	COG1841	ribosomal large subunit assembly
K3X53_01320	COG0200	Binds to the 23S rRNA
K3X53_01325	COG0201	protein transport
K3X53_01330	COG0563	adenylate kinase activity
K3X53_01335	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
K3X53_01340	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
K3X53_01345	COG0202	RNA polymerase activity
K3X53_01350	COG0203	ribosomal protein L17
K3X53_01360	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
K3X53_01375	COG0564	pseudouridine synthase activity
K3X53_01380	COG0546	phosphoglycolate phosphatase activity
K3X53_01390	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K3X53_01395	COG4597	amino acid ABC transporter
K3X53_01400	COG0765	amino acid transport
K3X53_01405	COG1126	abc transporter atp-binding protein
K3X53_01430	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
K3X53_01435	COG1028	Short-chain dehydrogenase reductase Sdr
K3X53_01440	COG0218	Necessary for normal cell division and for the maintenance of normal septation
K3X53_01450	COG0706	membrane insertase activity
K3X53_01455	COG5001	Diguanylate cyclase
K3X53_01460	COG0037	tRNA processing
K3X53_01475	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
K3X53_01480	COG0594	ribonuclease P activity
K3X53_01485	COG0230	Belongs to the bacterial ribosomal protein bL34 family
K3X53_01490	COG3734	2-keto-3-deoxy-galactonokinase
K3X53_01515	COG1385	rRNA (uridine-N3-)-methyltransferase activity
K3X53_01520	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
K3X53_01525	COG2885	chlorophyll binding
K3X53_01525	COG3047	cAMP biosynthetic process
K3X53_01545	COG1739	Uncharacterized protein family UPF0029
K3X53_01565	COG1435	thymidine kinase activity
K3X53_01570	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
K3X53_01575	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K3X53_01595	COG1136	(ABC) transporter
K3X53_01600	COG0438	transferase activity, transferring glycosyl groups
K3X53_01620	COG0187	DNA topoisomerase II activity
K3X53_01625	COG4335	DNA alkylation repair
K3X53_01630	COG0101	tRNA pseudouridine synthase activity
K3X53_01635	COG3106	COG3106 Predicted ATPase
K3X53_01645	COG3768	UPF0283 membrane protein
K3X53_01670	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
K3X53_01680	COG1131	(ABC) transporter
K3X53_01685	COG0842	Transport permease protein
K3X53_01690	COG0616	signal peptide processing
K3X53_01690	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
K3X53_01710	COG0322	excinuclease ABC activity
K3X53_01715	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
K3X53_01725	COG0314	molybdopterin synthase activity
K3X53_01735	COG1183	phosphatidylcholine synthase activity
K3X53_01750	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
K3X53_01760	COG2391	methyltransferase activity
K3X53_01770	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
K3X53_01775	COG2264	protein methyltransferase activity
K3X53_01800	COG2814	Major facilitator Superfamily
K3X53_01810	COG1045	serine acetyltransferase
K3X53_01815	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K3X53_01825	COG1570	exodeoxyribonuclease VII activity
K3X53_01835	COG0590	tRNA wobble adenosine to inosine editing
K3X53_01855	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
K3X53_01860	COG0154	amidase activity
K3X53_01870	COG3023	N-Acetylmuramoyl-L-alanine amidase
K3X53_01880	COG0267	Belongs to the bacterial ribosomal protein bL33 family
K3X53_01895	COG0670	Belongs to the BI1 family
K3X53_01905	COG0583	DNA-binding transcription factor activity
K3X53_01910	COG0604	alcohol dehydrogenase
K3X53_01910	COG1028	Short-chain dehydrogenase reductase Sdr
K3X53_01910	COG3321	synthase
K3X53_01920	COG0483	inositol monophosphate 1-phosphatase activity
K3X53_01930	COG0402	S-adenosylhomocysteine deaminase activity
K3X53_01935	COG2239	Acts as a magnesium transporter
K3X53_01940	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
K3X53_01945	COG3273	potassium ion transport
K3X53_01945	COG0471	metal ion transport
K3X53_01950	COG1280	lysine exporter protein (LysE YggA)
K3X53_01970	COG0217	transcriptional regulatory protein
K3X53_01975	COG0778	Nitroreductase
K3X53_01990	COG0747	negative chemotaxis
K3X53_01995	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
K3X53_02000	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
K3X53_02005	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
K3X53_02045	COG1012	belongs to the aldehyde dehydrogenase family
K3X53_02060	COG0601	transmembrane transport
K3X53_02065	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K3X53_02075	COG4608	Belongs to the ABC transporter superfamily
K3X53_02085	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K3X53_02085	COG1042	CoA-binding domain protein
K3X53_02085	COG0045	succinate-CoA ligase (ADP-forming) activity
K3X53_02090	COG0123	including yeast histone deacetylase and acetoin utilization protein
K3X53_02105	COG0667	Aldo Keto reductase
K3X53_02115	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
K3X53_02125	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K3X53_02130	COG1079	Belongs to the binding-protein-dependent transport system permease family
K3X53_02135	COG4603	Belongs to the binding-protein-dependent transport system permease family
K3X53_02140	COG3845	ABC transporter
K3X53_02150	COG1529	Aldehyde oxidase and xanthine dehydrogenase
K3X53_02170	COG2900	Belongs to the SlyX family
K3X53_02175	COG0124	histidyl-tRNA synthetase
K3X53_02180	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
K3X53_02185	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
K3X53_02195	COG0180	Tryptophanyl-tRNA synthetase
K3X53_02210	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
K3X53_02220	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
K3X53_02225	COG0792	nuclease activity
K3X53_02230	COG0189	ligase activity
K3X53_02240	COG0606	chelatase, subunit chli
K3X53_02265	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
K3X53_02270	COG0756	dUTP diphosphatase activity
K3X53_02275	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
K3X53_02290	COG0765	amino acid transport
K3X53_02295	COG0339	signal peptide processing
K3X53_02300	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
K3X53_02365	COG3118	belongs to the thioredoxin family
K3X53_02370	COG0509	glycine decarboxylation via glycine cleavage system
K3X53_02380	COG0534	Mate efflux family protein
K3X53_02390	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
K3X53_02420	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
K3X53_02440	COG0768	penicillin binding
K3X53_02445	COG0772	Belongs to the SEDS family
K3X53_02485	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K3X53_02500	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
K3X53_02505	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
K3X53_02510	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
K3X53_02515	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
K3X53_02520	COG0355	proton-transporting ATP synthase activity, rotational mechanism
K3X53_02550	COG0596	Alpha beta hydrolase
K3X53_02550	COG0508	dehydrogenase complex catalyzes the overall conversion of
K3X53_02560	COG2983	Belongs to the UPF0260 family
K3X53_02570	COG0196	riboflavin kinase activity
K3X53_02575	COG2030	dehydratase
K3X53_02590	COG1227	inorganic diphosphatase activity
K3X53_02600	COG1858	cytochrome C peroxidase
K3X53_02610	COG0459	protein refolding
K3X53_02625	COG0635	Involved in the biosynthesis of porphyrin-containing compound
K3X53_02630	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K3X53_02655	COG2010	Cytochrome c
K3X53_02660	COG0348	domain, Protein
K3X53_02680	COG2197	response regulator
K3X53_02690	COG4181	ATPase activity
K3X53_02695	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
K3X53_02730	COG2030	dehydratase
K3X53_02740	COG2301	Belongs to the HpcH HpaI aldolase family
K3X53_02755	COG0039	L-malate dehydrogenase activity
K3X53_02765	COG0045	succinate-CoA ligase (ADP-forming) activity
K3X53_02780	COG0567	Dehydrogenase, E1 component
K3X53_02785	COG0508	dehydrogenase complex catalyzes the overall conversion of
K3X53_02825	COG0642	Histidine kinase
K3X53_02855	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
K3X53_02875	COG0356	it plays a direct role in the translocation of protons across the membrane
K3X53_02880	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
K3X53_02885	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
K3X53_02890	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
K3X53_02900	COG2186	Transcriptional regulator
K3X53_02905	COG2885	chlorophyll binding
K3X53_02915	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
K3X53_02920	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K3X53_02925	COG1765	OsmC-like protein
K3X53_02950	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
K3X53_02950	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
K3X53_02970	COG3622	Belongs to the hyi family
K3X53_02980	COG0714	Associated with various cellular activities
K3X53_03000	COG0277	FAD linked oxidase domain protein
K3X53_03005	COG0277	FAD linked oxidase domain protein
K3X53_03010	COG0247	lactate metabolic process
K3X53_03020	COG0071	Belongs to the small heat shock protein (HSP20) family
K3X53_03030	COG3191	aminopeptidase activity
K3X53_03040	COG3214	Protein conserved in bacteria
K3X53_03050	COG1012	belongs to the aldehyde dehydrogenase family
K3X53_03060	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K3X53_03070	COG0489	protein tyrosine kinase activity
K3X53_03070	COG2151	metal-sulfur cluster biosynthetic enzyme
K3X53_03090	COG0254	rRNA binding
K3X53_03095	COG0335	large ribosomal subunit rRNA binding
K3X53_03100	COG0336	Belongs to the RNA methyltransferase TrmD family
K3X53_03110	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
K3X53_03115	COG0778	Nitroreductase
K3X53_03120	COG0228	four-way junction DNA binding
K3X53_03140	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
K3X53_03160	COG1054	Belongs to the UPF0176 family
K3X53_03170	COG1434	Gram-negative-bacterium-type cell wall biogenesis
K3X53_03190	COG1280	lysine exporter protein (LysE YggA)
K3X53_03200	COG1309	transcriptional regulator
K3X53_03205	COG3119	arylsulfatase activity
K3X53_03210	COG1012	belongs to the aldehyde dehydrogenase family
K3X53_03225	COG3800	Transcriptional regulator
K3X53_03225	COG1396	sequence-specific DNA binding
K3X53_03230	COG2814	Major facilitator Superfamily
K3X53_03235	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
K3X53_03260	COG4770	biotin carboxylase activity
K3X53_03270	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
K3X53_03270	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
K3X53_03280	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
K3X53_03285	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
K3X53_03305	COG0248	Ppx GppA phosphatase
K3X53_03310	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
K3X53_03320	COG0628	permease
K3X53_03335	COG0442	prolyl-tRNA aminoacylation
K3X53_03345	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
K3X53_03350	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
K3X53_03370	COG0529	Catalyzes the synthesis of activated sulfate
K3X53_03370	COG2046	Belongs to the sulfate adenylyltransferase family
K3X53_03380	COG0492	ferredoxin-NADP+ reductase activity
K3X53_03385	COG1522	sequence-specific DNA binding
K3X53_03395	COG1496	oxidoreductase activity
K3X53_03405	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
K3X53_03420	COG1573	uracil-dna glycosylase
K3X53_03435	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
K3X53_03450	COG2877	3-deoxy-8-phosphooctulonate synthase activity
K3X53_03460	COG0463	Glycosyl transferase, family 2
K3X53_03505	COG0174	glutamine synthetase
K3X53_03530	COG0022	dehydrogenase e1 component
K3X53_03535	COG0583	DNA-binding transcription factor activity
K3X53_03545	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K3X53_03550	COG1012	belongs to the aldehyde dehydrogenase family
K3X53_03555	COG0583	DNA-binding transcription factor activity
K3X53_03565	COG0556	nucleotide-excision repair
K3X53_03575	COG2267	carboxylic ester hydrolase activity
K3X53_03585	COG3739	integral membrane protein
K3X53_03595	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
K3X53_03610	COG2204	response regulator
K3X53_03620	COG0280	phosphate acetyltransferase
K3X53_03620	COG0281	malic enzyme
K3X53_03630	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
K3X53_03635	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
K3X53_03640	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
K3X53_03655	COG0318	PFAM AMP-dependent synthetase and ligase
K3X53_03660	COG0697	spore germination
K3X53_03670	COG1024	Enoyl-CoA hydratase
K3X53_03670	COG1250	3-hydroxyacyl-CoA dehydrogenase
K3X53_03675	COG0183	Belongs to the thiolase family
K3X53_03680	COG0625	glutathione transferase activity
K3X53_03690	COG1960	acyl-CoA dehydrogenase activity
K3X53_03725	COG0534	Mate efflux family protein
K3X53_03730	COG1393	Belongs to the ArsC family
K3X53_03745	COG3257	ureidoglycine aminohydrolase activity
K3X53_03755	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
K3X53_03765	COG0737	Belongs to the 5'-nucleotidase family
K3X53_03775	COG2135	peptidase activity
K3X53_03780	COG0154	amidase activity
K3X53_03785	COG0318	PFAM AMP-dependent synthetase and ligase
K3X53_03790	COG0174	glutamine synthetase
K3X53_03795	COG1177	transmembrane transport
K3X53_03800	COG1176	ABC-type spermidine putrescine transport system, permease component I
K3X53_03805	COG3842	ATPase activity
K3X53_03835	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
K3X53_03840	COG0602	queuosine metabolic process
K3X53_03845	COG0720	synthase
K3X53_03850	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
K3X53_03860	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
K3X53_03875	COG1492	cobalamin metabolic process
K3X53_03885	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
K3X53_03895	COG0354	folic acid binding
K3X53_03900	COG1132	(ABC) transporter
K3X53_03910	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
K3X53_03915	COG0525	valine-tRNA ligase activity
K3X53_03920	COG0033	Phosphoglucomutase
K3X53_03930	COG0019	diaminopimelate decarboxylase activity
K3X53_03950	COG0583	DNA-binding transcription factor activity
K3X53_03955	COG0483	inositol monophosphate 1-phosphatase activity
K3X53_03980	COG1136	(ABC) transporter
K3X53_04000	COG3842	ATPase activity
K3X53_04010	COG1176	ABC-type spermidine putrescine transport system, permease component I
K3X53_04015	COG1177	transmembrane transport
K3X53_04020	COG0740	serine-type endopeptidase activity
K3X53_04025	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
K3X53_04045	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
K3X53_04050	COG0439	Biotin carboxylase
K3X53_04065	COG1309	transcriptional regulator
K3X53_04090	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
K3X53_04095	COG0410	ABC transporter
K3X53_04120	COG1396	sequence-specific DNA binding
K3X53_04120	COG3800	Transcriptional regulator
K3X53_04125	COG0745	RESPONSE REGULATOR receiver
K3X53_04135	COG2205	protein histidine kinase activity
K3X53_04145	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
K3X53_04160	COG3750	Belongs to the UPF0335 family
K3X53_04165	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
K3X53_04170	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
K3X53_04240	COG0840	transmembrane signaling receptor activity
K3X53_04260	COG0028	Belongs to the TPP enzyme family
K3X53_04265	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K3X53_04275	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
K3X53_04280	COG0518	GMP synthase (glutamine-hydrolyzing) activity
K3X53_04280	COG0519	Catalyzes the synthesis of GMP from XMP
K3X53_04310	COG0488	(ABC) transporter
K3X53_04320	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
K3X53_04330	COG0625	glutathione transferase activity
K3X53_04340	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
K3X53_04350	COG2326	polyphosphate kinase activity
K3X53_04355	COG2951	lytic endotransglycosylase activity
K3X53_04360	COG0534	Mate efflux family protein
K3X53_04410	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
K3X53_04420	COG1278	Cold shock
K3X53_04425	COG1393	Belongs to the ArsC family
K3X53_04445	COG3220	belongs to the UPF0276 family
K3X53_04455	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
K3X53_04465	COG2267	carboxylic ester hydrolase activity
K3X53_04490	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
K3X53_04495	COG0303	'Molybdopterin
K3X53_04505	COG0315	cyclic pyranopterin monophosphate synthase activity
K3X53_04515	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
K3X53_04520	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
K3X53_04545	COG0148	phosphopyruvate hydratase activity
K3X53_04560	COG0384	phenazine biosynthesis protein PhzF
K3X53_04575	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
K3X53_04580	COG0456	acetyltransferase
K3X53_04585	COG1957	nucleoside hydrolase
K3X53_04595	COG2081	HI0933 family
K3X53_04600	COG0316	Belongs to the HesB IscA family
K3X53_04605	COG0232	Belongs to the dGTPase family. Type 2 subfamily
K3X53_04610	COG0018	arginyl-trna synthetase
K3X53_04620	COG1472	Belongs to the glycosyl hydrolase 3 family
K3X53_04625	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
K3X53_04630	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
K3X53_04640	COG0717	Belongs to the dCTP deaminase family
K3X53_04655	COG0776	regulation of translation
K3X53_04660	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
K3X53_04665	COG0416	fatty acid biosynthetic process
K3X53_04670	COG0333	Belongs to the bacterial ribosomal protein bL32 family
K3X53_04685	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
K3X53_04695	COG0488	(ABC) transporter
K3X53_04705	COG1272	protein, Hemolysin III
K3X53_04710	COG0076	glutamate decarboxylase activity
K3X53_04715	COG0149	triose-phosphate isomerase activity
K3X53_04720	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
K3X53_04725	COG0316	Belongs to the HesB IscA family
K3X53_04740	COG2151	metal-sulfur cluster biosynthetic enzyme
K3X53_04745	COG0343	queuine tRNA-ribosyltransferase activity
K3X53_04755	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
K3X53_04780	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
K3X53_04785	COG0328	RNA-DNA hybrid ribonuclease activity
K3X53_04795	COG3617	BRO family, N-terminal domain
K3X53_04820	COG0406	alpha-ribazole phosphatase activity
K3X53_04845	COG0156	8-amino-7-oxononanoate synthase activity
K3X53_04855	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
K3X53_04865	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
K3X53_04875	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K3X53_04885	COG0404	The glycine cleavage system catalyzes the degradation of glycine
K3X53_04885	COG0446	pyridine nucleotide-disulphide oxidoreductase
K3X53_04925	COG2962	Rard protein
K3X53_04940	COG5265	(ABC) transporter
K3X53_04945	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K3X53_04965	COG1160	GTP binding
K3X53_04985	COG4221	oxidoreductase activity
K3X53_05000	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
K3X53_05025	COG1127	ABC transporter
K3X53_05030	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
K3X53_05060	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
K3X53_05080	COG0544	peptidyl-prolyl cis-trans isomerase activity
K3X53_05090	COG0359	binds to the 23S rRNA
K3X53_05095	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
K3X53_05100	COG0360	Binds together with S18 to 16S ribosomal RNA
K3X53_05110	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
K3X53_05120	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
K3X53_05125	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
K3X53_05130	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
K3X53_05145	COG4695	Portal protein
K3X53_05235	COG0508	dehydrogenase complex catalyzes the overall conversion of
K3X53_05240	COG0022	dehydrogenase e1 component
K3X53_05240	COG0508	dehydrogenase complex catalyzes the overall conversion of
K3X53_05245	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
K3X53_05250	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
K3X53_05255	COG3588	fructose-bisphosphate aldolase
K3X53_05285	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
K3X53_05295	COG0436	Aminotransferase
K3X53_05300	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
K3X53_05305	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
K3X53_05315	COG0006	proline dipeptidase activity
K3X53_05320	COG1473	amidohydrolase
K3X53_05355	COG0826	peptidase U32
K3X53_05360	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
K3X53_05365	COG0308	aminopeptidase N
K3X53_05370	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
K3X53_05380	COG2155	Conserved Protein
K3X53_05385	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
K3X53_05410	COG2010	Cytochrome c
K3X53_05410	COG1529	Aldehyde oxidase and xanthine dehydrogenase
K3X53_05425	COG0436	Aminotransferase
K3X53_05440	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
K3X53_05460	COG1741	Belongs to the pirin family
K3X53_05475	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
K3X53_05490	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
K3X53_05495	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
K3X53_05510	COG0812	UDP-N-acetylmuramate dehydrogenase activity
K3X53_05515	COG1181	Belongs to the D-alanine--D-alanine ligase family
K3X53_05520	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
K3X53_05525	COG0849	cell division
K3X53_05530	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
K3X53_05535	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
K3X53_05540	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K3X53_05550	COG0277	FAD linked oxidase domain protein
K3X53_05555	COG0038	chloride channel
K3X53_05560	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
K3X53_05565	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
K3X53_05575	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
K3X53_05590	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
K3X53_05605	COG2095	MarC family integral membrane protein
K3X53_05610	COG0488	(ABC) transporter
K3X53_05615	COG0105	UTP biosynthetic process
K3X53_05650	COG0784	Response regulator, receiver
K3X53_05650	COG2198	Histidine kinase
K3X53_05650	COG2205	protein histidine kinase activity
K3X53_05670	COG0730	response to heat
K3X53_05720	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
K3X53_05735	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
K3X53_05745	COG1522	sequence-specific DNA binding
K3X53_05775	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K3X53_05780	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
K3X53_05795	COG0433	COG0433 Predicted ATPase
K3X53_05805	COG4536	flavin adenine dinucleotide binding
K3X53_05815	COG0004	ammonium transporteR
K3X53_05855	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
K3X53_05860	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
K3X53_05865	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
K3X53_05875	COG2166	iron-sulfur cluster assembly
K3X53_05890	COG5012	cobalamin binding
K3X53_05900	COG0646	methionine synthase
K3X53_05900	COG1410	methionine synthase
K3X53_05915	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
K3X53_05920	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
K3X53_05925	COG0047	phosphoribosylformylglycinamidine synthase activity
K3X53_05935	COG2204	response regulator
K3X53_05940	COG0457	Tetratricopeptide repeat
K3X53_05945	COG0261	This protein binds to 23S rRNA in the presence of protein L20
K3X53_05945	COG3743	rRNA binding
K3X53_05950	COG0211	Belongs to the bacterial ribosomal protein bL27 family
K3X53_05970	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
K3X53_05975	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
K3X53_05980	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
K3X53_06020	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
K3X53_06030	COG2321	neutral zinc metallopeptidase
K3X53_06055	COG0626	cystathionine gamma-synthase activity
K3X53_06115	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
K3X53_06125	COG1561	YicC-like family, N-terminal region
K3X53_06130	COG0194	GDP metabolic process
K3X53_06145	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
K3X53_06155	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
K3X53_06160	COG2867	negative regulation of translational initiation
K3X53_06165	COG4974	Belongs to the 'phage' integrase family
K3X53_06180	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
K3X53_06185	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
K3X53_06190	COG1546	Belongs to the CinA family
K3X53_06190	COG1058	Belongs to the CinA family
K3X53_06200	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
K3X53_06200	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
K3X53_06205	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
K3X53_06210	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
K3X53_06215	COG3852	Histidine kinase
K3X53_06220	COG2204	response regulator
K3X53_06225	COG5000	phosphorelay sensor kinase activity
K3X53_06230	COG2204	response regulator
K3X53_06235	COG0569	domain protein
K3X53_06240	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
K3X53_06250	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
K3X53_06260	COG2084	Dehydrogenase
K3X53_06280	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
K3X53_06285	COG2814	Major facilitator Superfamily
K3X53_06295	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
K3X53_06310	COG1028	Short-chain dehydrogenase reductase Sdr
K3X53_06325	COG2313	pseudouridylate synthase activity
K3X53_06330	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
K3X53_06330	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
K3X53_06335	COG0052	Belongs to the universal ribosomal protein uS2 family
K3X53_06340	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
K3X53_06345	COG2197	response regulator
K3X53_06350	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
K3X53_06360	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K3X53_06365	COG4311	Sarcosine oxidase, delta subunit
K3X53_06370	COG0446	pyridine nucleotide-disulphide oxidoreductase
K3X53_06370	COG0404	The glycine cleavage system catalyzes the degradation of glycine
K3X53_06380	COG4977	sequence-specific DNA binding
K3X53_06390	COG1012	belongs to the aldehyde dehydrogenase family
K3X53_06410	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
K3X53_06415	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
K3X53_06425	COG0824	Thioesterase
K3X53_06425	COG1250	3-hydroxyacyl-CoA dehydrogenase
K3X53_06430	COG1028	Short-chain dehydrogenase reductase Sdr
K3X53_06435	COG3246	L-lysine catabolic process to acetate
K3X53_06440	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
K3X53_06455	COG0251	oxidation-reduction process
K3X53_06460	COG3831	ATPase activity
K3X53_06465	COG0714	Associated with various cellular activities
K3X53_06470	COG2425	protein containing a von Willebrand factor type A (vWA) domain
K3X53_06475	COG3552	Protein containing von Willebrand factor type A (VWA) domain
K3X53_06485	COG0745	RESPONSE REGULATOR receiver
K3X53_06495	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
K3X53_06505	COG0573	inorganic phosphate transmembrane transporter activity
K3X53_06520	COG5002	protein histidine kinase activity
K3X53_06540	COG5598	trimethylamine methyltransferase
K3X53_06545	COG0519	Catalyzes the synthesis of GMP from XMP
K3X53_06545	COG0518	GMP synthase (glutamine-hydrolyzing) activity
K3X53_06570	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
K3X53_06575	COG2326	polyphosphate kinase activity
K3X53_06580	COG1309	transcriptional regulator
K3X53_06585	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
K3X53_06600	COG0719	Fe-S assembly protein
K3X53_06605	COG0396	ATPase activity
K3X53_06625	COG0719	Fe-S assembly protein
K3X53_06630	COG1104	cysteine desulfurase activity
K3X53_06640	COG1959	2 iron, 2 sulfur cluster binding
K3X53_06645	COG2945	thiolester hydrolase activity
K3X53_06665	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
K3X53_06670	COG1612	heme a metabolic process
K3X53_06675	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
K3X53_06685	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
K3X53_06690	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
K3X53_06695	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
K3X53_06705	COG0840	transmembrane signaling receptor activity
K3X53_06710	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
K3X53_06715	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
K3X53_06720	COG0745	RESPONSE REGULATOR receiver
K3X53_06730	COG0482	sulfurtransferase activity
K3X53_06740	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K3X53_06750	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K3X53_06755	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
K3X53_06765	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K3X53_06775	COG0750	zinc metalloprotease
K3X53_06780	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
K3X53_06790	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
K3X53_06795	COG0233	cytoplasmic translational termination
K3X53_06800	COG0528	UMP kinase activity
K3X53_06810	COG2207	Transcriptional regulator
K3X53_06815	COG0741	lytic transglycosylase activity
K3X53_06820	COG0629	single-stranded DNA binding
K3X53_06840	COG1686	Belongs to the peptidase S11 family
K3X53_06845	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
K3X53_06855	COG0084	hydrolase, TatD family'
K3X53_06880	COG3396	Phenylacetate-CoA oxygenase
K3X53_06885	COG3460	Phenylacetate-CoA oxygenase
K3X53_06890	COG3396	Phenylacetate-CoA oxygenase
K3X53_06895	COG2151	metal-sulfur cluster biosynthetic enzyme
K3X53_06900	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
K3X53_06910	COG1012	belongs to the aldehyde dehydrogenase family
K3X53_06910	COG2030	dehydratase
K3X53_06935	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
K3X53_06950	COG1024	Enoyl-CoA hydratase
K3X53_06955	COG0121	glutamine amidotransferase
K3X53_06965	COG1217	gtp-binding protein TYPA
K3X53_06980	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
K3X53_06985	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
K3X53_06995	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
K3X53_06995	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
K3X53_07000	COG0516	GMP reductase activity
K3X53_07000	COG0517	IMP dehydrogenase activity
K3X53_07030	COG0542	response to heat
K3X53_07050	COG2814	Major facilitator Superfamily
K3X53_07075	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
K3X53_07085	COG0129	dihydroxy-acid dehydratase activity
K3X53_07090	COG0800	Aldolase
K3X53_07100	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
K3X53_07105	COG0215	cysteine-tRNA ligase activity
K3X53_07190	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
K3X53_07195	COG0737	Belongs to the 5'-nucleotidase family
K3X53_07200	COG3258	Cytochrome c
K3X53_07220	COG0785	Cytochrome C biogenesis protein
K3X53_07235	COG2391	methyltransferase activity
K3X53_07260	COG2873	o-acetylhomoserine
K3X53_07265	COG2968	Membrane
K3X53_07275	COG1522	sequence-specific DNA binding
K3X53_07280	COG0840	transmembrane signaling receptor activity
K3X53_07285	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
K3X53_07290	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
K3X53_07295	COG1329	Transcriptional regulator
K3X53_07300	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
K3X53_07305	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
K3X53_07340	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
K3X53_07370	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
K3X53_07380	COG1797	cobyrinic acid a,c-diamide synthase activity
K3X53_07385	COG2814	Major facilitator Superfamily
K3X53_07395	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
K3X53_07420	COG0028	Belongs to the TPP enzyme family
K3X53_07425	COG0440	acetolactate synthase activity
K3X53_07435	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
K3X53_07460	COG0259	pyridoxamine-phosphate oxidase activity
K3X53_07465	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
K3X53_07470	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
K3X53_07480	COG2890	protein-(glutamine-N5) methyltransferase activity
K3X53_07485	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
K3X53_07495	COG0010	Belongs to the arginase family
K3X53_07500	COG1473	amidohydrolase
K3X53_07505	COG3956	TIGRFAM MazG family protein
K3X53_07510	COG1840	ABC-type Fe3 transport system, periplasmic component
K3X53_07520	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
K3X53_07530	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K3X53_07545	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
K3X53_07555	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
K3X53_07560	COG2833	Protein of unknown function (DUF455)
K3X53_07565	COG0739	heme binding
K3X53_07580	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
K3X53_07585	COG3842	ATPase activity
K3X53_07590	COG0395	ABC-type sugar transport system, permease component
K3X53_07595	COG1175	transmembrane transport
K3X53_07600	COG1653	transport
K3X53_07610	COG0745	RESPONSE REGULATOR receiver
K3X53_07620	COG0835	chemotaxis
K3X53_07625	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
K3X53_07630	COG0745	RESPONSE REGULATOR receiver
K3X53_07645	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
K3X53_07650	COG2201	protein-glutamate methylesterase activity
K3X53_07655	COG0840	transmembrane signaling receptor activity
K3X53_07665	COG0784	Response regulator, receiver
K3X53_07665	COG2205	protein histidine kinase activity
K3X53_07665	COG5002	protein histidine kinase activity
K3X53_07680	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
K3X53_07735	COG4964	Belongs to the GSP D family
K3X53_07795	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
K3X53_07800	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
K3X53_07800	COG3264	Mechanosensitive ion channel
K3X53_07810	COG0494	nUDIX hydrolase
K3X53_07820	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
K3X53_07825	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
K3X53_07830	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
K3X53_07845	COG0604	alcohol dehydrogenase
K3X53_07850	COG0404	The glycine cleavage system catalyzes the degradation of glycine
K3X53_07885	COG0114	fumarate hydratase activity
K3X53_07915	COG0785	Cytochrome C biogenesis protein
K3X53_07920	COG0425	Belongs to the sulfur carrier protein TusA family
K3X53_07925	COG1530	ribonuclease E activity
K3X53_07930	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
K3X53_07935	COG1164	Oligoendopeptidase f
K3X53_07955	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
K3X53_07985	COG0564	pseudouridine synthase activity
K3X53_08020	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
K3X53_08025	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
K3X53_08030	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
K3X53_08030	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
K3X53_08065	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
K3X53_08065	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
K3X53_08075	COG0432	Pfam Uncharacterised protein family UPF0047
K3X53_08095	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
K3X53_08100	COG0358	DNA primase activity
K3X53_08105	COG1309	transcriptional regulator
K3X53_08125	COG1335	isochorismatase
K3X53_08130	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
K3X53_08140	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
K3X53_08150	COG1984	allophanate hydrolase subunit 2
K3X53_08175	COG0546	phosphoglycolate phosphatase activity
K3X53_08220	COG1250	3-hydroxyacyl-CoA dehydrogenase
K3X53_08220	COG0824	Thioesterase
K3X53_08230	COG3246	L-lysine catabolic process to acetate
K3X53_08240	COG0667	Aldo Keto reductase
K3X53_08245	COG1028	Short-chain dehydrogenase reductase Sdr
K3X53_08270	COG0513	Belongs to the DEAD box helicase family
K3X53_08280	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
K3X53_08290	COG1007	ATP synthesis coupled electron transport
K3X53_08305	COG0713	ATP synthesis coupled electron transport
K3X53_08320	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
K3X53_08325	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
K3X53_08360	COG0649	NAD binding
K3X53_08370	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
K3X53_08375	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
K3X53_08385	COG1024	Enoyl-CoA hydratase
K3X53_08400	COG4770	biotin carboxylase activity
K3X53_08405	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
K3X53_08415	COG1960	acyl-CoA dehydrogenase activity
K3X53_08425	COG0546	phosphoglycolate phosphatase activity
K3X53_08430	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
K3X53_08450	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
K3X53_08460	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
K3X53_08465	COG1473	amidohydrolase
K3X53_08470	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K3X53_08490	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
K3X53_08495	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
K3X53_08500	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
K3X53_08515	COG0275	rRNA processing
K3X53_08520	COG2001	Belongs to the MraZ family
K3X53_08530	COG0489	protein tyrosine kinase activity
K3X53_08540	COG0210	DNA helicase
K3X53_08545	COG1754	DNA topoisomerase type I activity
K3X53_08545	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
K3X53_08545	COG1754	DNA topoisomerase type I activity
K3X53_08545	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
K3X53_08550	COG3273	potassium ion transport
K3X53_08550	COG0471	metal ion transport
K3X53_08585	COG0277	FAD linked oxidase domain protein
K3X53_08590	COG1028	Short-chain dehydrogenase reductase Sdr
K3X53_08625	COG4964	Belongs to the GSP D family
K3X53_08680	COG1201	RNA secondary structure unwinding
K3X53_08695	COG1024	Enoyl-CoA hydratase
K3X53_08705	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
K3X53_08710	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
K3X53_08715	COG2759	Belongs to the formate--tetrahydrofolate ligase family
K3X53_08720	COG3239	Fatty acid desaturase
K3X53_08730	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
K3X53_08735	COG0037	tRNA processing
K3X53_08745	COG2885	chlorophyll binding
K3X53_08775	COG0824	Thioesterase
K3X53_08790	COG2255	four-way junction helicase activity
K3X53_08795	COG0632	four-way junction helicase activity
K3X53_08805	COG1053	succinate dehydrogenase
K3X53_08820	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
K3X53_08835	COG0330	HflC and HflK could
K3X53_08840	COG0330	HflC and HflK could
K3X53_08850	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
K3X53_08855	COG2832	Protein of unknown function (DUF454)
K3X53_08860	COG1760	l-serine dehydratase
K3X53_08885	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
K3X53_08895	COG0504	CTP synthase activity
K3X53_08925	COG4215	(ABC) transporter
K3X53_08935	COG0518	GMP synthase (glutamine-hydrolyzing) activity
K3X53_08935	COG0519	Catalyzes the synthesis of GMP from XMP
K3X53_08940	COG0174	glutamine synthetase
K3X53_08945	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
K3X53_08950	COG0583	DNA-binding transcription factor activity
K3X53_08955	COG0658	competence protein
K3X53_08955	COG2333	competence protein COMEC
K3X53_08960	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
K3X53_08970	COG1024	Enoyl-CoA hydratase
K3X53_08975	COG3088	subunit of a heme lyase
K3X53_08980	COG1138	Cytochrome C-type biogenesis protein
K3X53_09005	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
K3X53_09010	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
K3X53_09030	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
K3X53_09035	COG1357	PFAM Pentapeptide repeats (8 copies)
K3X53_09045	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
K3X53_09060	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
K3X53_09065	COG0697	spore germination
K3X53_09070	COG2354	Protein conserved in bacteria
K3X53_09095	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
K3X53_09125	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
K3X53_09130	COG1960	acyl-CoA dehydrogenase activity
K3X53_09135	COG1024	Enoyl-CoA hydratase
K3X53_09155	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
K3X53_09160	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
K3X53_09165	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
K3X53_09180	COG4191	Histidine kinase
K3X53_09185	COG1522	sequence-specific DNA binding
K3X53_09195	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
K3X53_09200	COG0175	sulfate reduction
K3X53_09215	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
K3X53_09230	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
K3X53_09230	COG3608	succinylglutamate desuccinylase aspartoacylase
K3X53_09280	COG0418	dihydroorotase activity
K3X53_09285	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
K3X53_09290	COG0305	Participates in initiation and elongation during chromosome replication
K3X53_09310	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
K3X53_09320	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
K3X53_09335	COG0300	oxidoreductase activity
K3X53_09340	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K3X53_09350	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
K3X53_09355	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
K3X53_09360	COG4133	protoheme IX ABC transporter activity
K3X53_09365	COG3737	Protein of unknown function (DUF498/DUF598)
K3X53_09375	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
K3X53_09380	COG1862	Preprotein translocase
K3X53_09390	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
K3X53_09400	COG0805	protein transport
K3X53_09410	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
K3X53_09420	COG3842	ATPase activity
K3X53_09435	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K3X53_09450	COG1028	Short-chain dehydrogenase reductase Sdr
K3X53_09480	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
K3X53_09495	COG0659	secondary active sulfate transmembrane transporter activity
K3X53_09500	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
K3X53_09505	COG2311	Membrane
K3X53_09510	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
K3X53_09525	COG0612	Peptidase, M16
K3X53_09545	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
K3X53_09555	COG0109	protoheme IX farnesyltransferase activity
K3X53_09565	COG0312	modulator of DNA gyrase
K3X53_09580	COG0758	DNA mediated transformation
K3X53_09585	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
K3X53_09615	COG0131	Imidazoleglycerol-phosphate dehydratase
K3X53_09625	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
K3X53_09635	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
K3X53_09645	COG0107	imidazoleglycerol-phosphate synthase activity
K3X53_09650	COG0140	phosphoribosyl-ATP diphosphatase activity
K3X53_09665	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
K3X53_09675	COG1618	nucleotide phosphatase activity, acting on free nucleotides
K3X53_09675	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
K3X53_09680	COG3005	denitrification pathway
K3X53_09690	COG0348	domain, Protein
K3X53_09695	COG0437	4 iron, 4 sulfur cluster binding
K3X53_09700	COG0243	molybdopterin cofactor binding
K3X53_09710	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
K3X53_09710	COG2221	Nitrite and sulphite reductase 4Fe-4S
K3X53_09825	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
K3X53_09830	COG1530	ribonuclease E activity
K3X53_09840	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
K3X53_09865	COG5328	Belongs to the UPF0262 family
K3X53_09870	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
K3X53_09880	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
K3X53_09900	COG3916	Acyl-homoserine-lactone synthase
K3X53_09910	COG0318	PFAM AMP-dependent synthetase and ligase
K3X53_09915	COG1132	(ABC) transporter
K3X53_09920	COG0116	Belongs to the methyltransferase superfamily
K3X53_09920	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
K3X53_09930	COG2188	Transcriptional regulator
K3X53_09940	COG2267	carboxylic ester hydrolase activity
K3X53_09950	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
K3X53_09955	COG1012	belongs to the aldehyde dehydrogenase family
K3X53_09975	COG0826	peptidase U32
K3X53_09985	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
K3X53_10025	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
K3X53_10035	COG1805	sodium ion transport
K3X53_10040	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
K3X53_10045	COG1477	protein flavinylation
K3X53_10070	COG0321	lipoyl(octanoyl) transferase activity
K3X53_10075	COG3474	cytochrome
K3X53_10095	COG0505	Belongs to the CarA family
K3X53_10105	COG1802	Transcriptional regulator
K3X53_10140	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
K3X53_10150	COG0697	spore germination
K3X53_10155	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
K3X53_10175	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
K3X53_10175	COG0574	Belongs to the PEP-utilizing enzyme family
K3X53_10180	COG0751	glycine-tRNA ligase activity
K3X53_10190	COG0752	glycyl-tRNA synthetase alpha subunit
K3X53_10205	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
K3X53_10215	COG1469	GTP cyclohydrolase I activity
K3X53_10225	COG2917	probably involved in intracellular septation
K3X53_10235	COG0552	protein localization to endoplasmic reticulum
K3X53_10265	COG3853	Toxic anion resistance protein (TelA)
K3X53_10290	COG1490	D-aminoacyl-tRNA deacylase activity
K3X53_10300	COG0287	Prephenate dehydrogenase
K3X53_10305	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
K3X53_10315	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
K3X53_10335	COG1108	ABC-type Mn2 Zn2 transport systems permease components
K3X53_10365	COG2197	response regulator
K3X53_10380	COG0444	Belongs to the ABC transporter superfamily
K3X53_10385	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K3X53_10390	COG0601	transmembrane transport
K3X53_10440	COG0559	Belongs to the binding-protein-dependent transport system permease family
K3X53_10480	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
K3X53_10505	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
K3X53_10515	COG0232	Belongs to the dGTPase family. Type 2 subfamily
K3X53_10545	COG3273	potassium ion transport
K3X53_10545	COG0471	metal ion transport
K3X53_10555	COG1692	metallophosphoesterase
K3X53_10560	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
K3X53_10565	COG1214	PFAM Peptidase M22, glycoprotease
K3X53_10575	COG1744	ABC transporter substrate-binding protein PnrA-like
K3X53_10580	COG3845	ABC transporter
K3X53_10585	COG4603	Belongs to the binding-protein-dependent transport system permease family
K3X53_10590	COG1079	Belongs to the binding-protein-dependent transport system permease family
K3X53_10610	COG1028	Short-chain dehydrogenase reductase Sdr
K3X53_10625	COG2197	response regulator
K3X53_10635	COG0604	alcohol dehydrogenase
K3X53_10640	COG2937	Belongs to the GPAT DAPAT family
K3X53_10645	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
K3X53_10645	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
K3X53_10655	COG0813	purine-nucleoside phosphorylase activity
K3X53_10665	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
K3X53_10665	COG1618	nucleotide phosphatase activity, acting on free nucleotides
K3X53_10680	COG1250	3-hydroxyacyl-CoA dehydrogenase
K3X53_10685	COG1012	belongs to the aldehyde dehydrogenase family
K3X53_10690	COG1960	acyl-CoA dehydrogenase activity
K3X53_10695	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
K3X53_10700	COG3800	Transcriptional regulator
K3X53_10700	COG1396	sequence-specific DNA binding
K3X53_10705	COG1804	L-carnitine dehydratase bile acid-inducible protein F
K3X53_10725	COG0625	glutathione transferase activity
K3X53_10740	COG2963	transposase activity
K3X53_10750	COG1129	ABC transporter
K3X53_10755	COG4214	carbohydrate transport
K3X53_10765	COG1609	Transcriptional regulator
K3X53_10770	COG0673	inositol 2-dehydrogenase activity
K3X53_10780	COG0673	inositol 2-dehydrogenase activity
K3X53_10785	COG3962	Belongs to the TPP enzyme family
K3X53_10790	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K3X53_10800	COG0191	fructose-bisphosphate aldolase activity
K3X53_10805	COG0673	inositol 2-dehydrogenase activity
K3X53_10870	COG2353	YceI-like domain
K3X53_10880	COG0012	GTP binding
K3X53_10890	COG0159	tryptophan synthase activity
K3X53_10905	COG0513	Belongs to the DEAD box helicase family
K3X53_10925	COG0193	aminoacyl-tRNA hydrolase activity
K3X53_10940	COG0133	tryptophan synthase activity
K3X53_10945	COG0135	phosphoribosylanthranilate isomerase activity
K3X53_10955	COG0776	regulation of translation
K3X53_10960	COG0539	negative regulation of cytoplasmic translation
K3X53_10970	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
K3X53_10990	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
K3X53_10995	COG0220	tRNA (guanine-N7-)-methyltransferase activity
K3X53_11000	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
K3X53_11005	COG0815	Transfers the fatty acyl group on membrane lipoproteins
K3X53_11010	COG1253	flavin adenine dinucleotide binding
K3X53_11015	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
K3X53_11020	COG1702	phosphate starvation-inducible protein PhoH
K3X53_11035	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
K3X53_11045	COG1047	Peptidyl-prolyl cis-trans
K3X53_11055	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
K3X53_11060	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
K3X53_11065	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
K3X53_11070	COG2267	carboxylic ester hydrolase activity
K3X53_11095	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
K3X53_11105	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K3X53_11130	COG2824	Alkylphosphonate utilization operon protein PhnA
K3X53_11145	COG0481	GTPase activity
K3X53_11165	COG1105	Belongs to the carbohydrate kinase PfkB family
K3X53_11175	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
K3X53_11185	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
K3X53_11200	COG0227	Belongs to the bacterial ribosomal protein bL28 family
K3X53_11210	COG1132	(ABC) transporter
K3X53_11215	COG1703	isobutyryl-CoA mutase activity
K3X53_11220	COG1643	Atp-dependent helicase
K3X53_11230	COG0306	phosphate transporter
K3X53_11240	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
K3X53_11245	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
K3X53_11265	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
K3X53_11285	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
K3X53_11285	COG0512	Glutamine amidotransferase of anthranilate synthase
K3X53_11295	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
K3X53_11310	COG0346	lactoylglutathione lyase activity
K3X53_11325	COG0778	Nitroreductase
K3X53_11335	COG1872	DUF167
K3X53_11340	COG3152	Membrane
K3X53_11345	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
K3X53_11370	COG0540	Belongs to the ATCase OTCase family
K3X53_11380	COG1573	uracil-dna glycosylase
K3X53_11385	COG0521	Mo-molybdopterin cofactor biosynthetic process
K3X53_11395	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K3X53_11405	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
K3X53_11425	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
K3X53_11430	COG0142	geranyltranstransferase activity
K3X53_11455	COG0583	DNA-binding transcription factor activity
K3X53_11460	COG1028	Short-chain dehydrogenase reductase Sdr
K3X53_11475	COG2818	Glycosylase
K3X53_11480	COG2951	lytic endotransglycosylase activity
K3X53_11495	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K3X53_11500	COG0165	Argininosuccinate lyase
K3X53_11505	COG0019	diaminopimelate decarboxylase activity
K3X53_11515	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
K3X53_11540	COG1162	GTPase activity
K3X53_11550	COG0737	Belongs to the 5'-nucleotidase family
K3X53_11555	COG2816	NAD+ diphosphatase activity
K3X53_11570	COG3474	cytochrome
K3X53_11575	COG4166	transmembrane transport
K3X53_11580	COG4174	ABC transporter (Permease)
K3X53_11585	COG4239	(ABC) transporter, permease
K3X53_11590	COG4172	Belongs to the ABC transporter superfamily
K3X53_11595	COG1686	Belongs to the peptidase S11 family
K3X53_11600	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
K3X53_11605	COG2813	Specifically methylates the guanine in position
K3X53_11615	COG0408	coproporphyrinogen oxidase activity
K3X53_11625	COG1846	Transcriptional regulator
K3X53_11630	COG0183	Belongs to the thiolase family
K3X53_11635	COG0181	hydroxymethylbilane synthase activity
K3X53_11640	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
K3X53_11650	COG0513	Belongs to the DEAD box helicase family
K3X53_11655	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
K3X53_11670	COG0288	reversible hydration of carbon dioxide
K3X53_11680	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
K3X53_11685	COG0791	NLP P60 protein
K3X53_11695	COG2050	protein possibly involved in aromatic compounds catabolism
K3X53_11720	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
K3X53_11735	COG0679	Auxin Efflux Carrier
K3X53_11745	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
K3X53_11750	COG1671	Belongs to the UPF0178 family
K3X53_11760	COG1280	lysine exporter protein (LysE YggA)
K3X53_11765	COG2897	thiosulfate sulfurtransferase activity
K3X53_11775	COG0004	ammonium transporteR
K3X53_11780	COG0347	Belongs to the P(II) protein family
K3X53_11810	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K3X53_11820	COG0584	glycerophosphoryl diester phosphodiesterase
K3X53_11830	COG2154	pterin-4-alpha-carbinolamine dehydratase
K3X53_11840	COG0742	ribosomal rna small subunit methyltransferase
K3X53_11845	COG0024	Methionine aminopeptidase
K3X53_11850	COG1489	DNA binding
K3X53_11855	COG1546	Belongs to the CinA family
K3X53_11855	COG1058	Belongs to the CinA family
K3X53_11875	COG0583	DNA-binding transcription factor activity
K3X53_11885	COG0446	pyridine nucleotide-disulphide oxidoreductase
K3X53_11885	COG1902	pentaerythritol trinitrate reductase activity
K3X53_11910	COG1266	CAAX protease self-immunity
K3X53_11915	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
K3X53_11920	COG0285	dihydrofolate synthase activity
K3X53_11935	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
K3X53_11950	COG0686	Belongs to the AlaDH PNT family
K3X53_11960	COG0668	transmembrane transport
K3X53_11965	COG1970	mechanosensitive ion channel activity
K3X53_11975	COG0072	phenylalanine-tRNA ligase activity
K3X53_11975	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K3X53_11995	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
K3X53_12000	COG1595	DNA-templated transcription, initiation
K3X53_12005	COG3795	YCII-related domain
K3X53_12015	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
K3X53_12020	COG0291	Belongs to the bacterial ribosomal protein bL35 family
K3X53_12030	COG0469	pyruvate kinase activity
K3X53_12055	COG3384	dioxygenase
K3X53_12070	COG4948	Mandelate Racemase Muconate Lactonizing
K3X53_12095	COG0825	malonyl-CoA metabolic process
K3X53_12115	COG2884	Cell division ATP-binding protein ftsE
K3X53_12150	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
K3X53_12155	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
K3X53_12165	COG0232	Belongs to the dGTPase family. Type 2 subfamily
K3X53_12180	COG0284	orotidine-5'-phosphate decarboxylase activity
K3X53_12200	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
K3X53_12215	COG0257	Belongs to the bacterial ribosomal protein bL36 family
K3X53_12230	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
K3X53_12250	COG0559	Belongs to the binding-protein-dependent transport system permease family
K3X53_12280	COG3383	formate dehydrogenase (NAD+) activity
K3X53_12320	COG0612	Peptidase, M16
K3X53_12325	COG0612	Peptidase, M16
K3X53_12335	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
K3X53_12340	COG0138	bifunctional purine biosynthesis protein purh
K3X53_12360	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
K3X53_12365	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
K3X53_12370	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
K3X53_12375	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
K3X53_12395	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
K3X53_12405	COG1185	polyribonucleotide nucleotidyltransferase activity
K3X53_12420	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
K3X53_12425	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
K3X53_12435	COG0560	Phosphoserine phosphatase
K3X53_12460	COG0820	rRNA (adenine-C2-)-methyltransferase activity
K3X53_12480	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
K3X53_12485	COG2171	N-acyltransferase activity
K3X53_12525	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
K3X53_12530	COG0557	exoribonuclease II activity
K3X53_12535	COG2951	lytic endotransglycosylase activity
K3X53_12555	COG1051	belongs to the nudix hydrolase family
K3X53_12560	COG0793	Belongs to the peptidase S41A family
K3X53_12570	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
K3X53_12580	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
K3X53_12585	COG0799	negative regulation of ribosome biogenesis
K3X53_12595	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
K3X53_12595	COG3264	Mechanosensitive ion channel
K3X53_12600	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
K3X53_12605	COG0066	3-isopropylmalate dehydratase activity
K3X53_12620	COG0473	3-isopropylmalate dehydrogenase activity
K3X53_12635	COG1960	acyl-CoA dehydrogenase activity
K3X53_12640	COG2329	Antibiotic biosynthesis monooxygenase
K3X53_12650	COG2233	PERMEase
K3X53_12655	COG0277	FAD linked oxidase domain protein
K3X53_12665	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
K3X53_12670	COG2186	Transcriptional regulator
K3X53_12675	COG0560	Phosphoserine phosphatase
K3X53_12685	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
K3X53_12690	COG0765	amino acid transport
K3X53_12695	COG1126	abc transporter atp-binding protein
K3X53_12700	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K3X53_12710	COG4608	Belongs to the ABC transporter superfamily
K3X53_12715	COG0444	Belongs to the ABC transporter superfamily
K3X53_12720	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K3X53_12725	COG0601	transmembrane transport
K3X53_12730	COG0747	negative chemotaxis
K3X53_12735	COG1802	Transcriptional regulator
K3X53_12760	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
K3X53_12765	COG4172	Belongs to the ABC transporter superfamily
K3X53_12775	COG0601	transmembrane transport
K3X53_12785	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
K3X53_12795	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
K3X53_12815	COG0798	PFAM Bile acid sodium symporter
K3X53_12820	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
K3X53_12830	COG1349	DNA-binding transcription factor activity
K3X53_12845	COG2010	Cytochrome c
K3X53_12860	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
K3X53_12865	COG2010	Cytochrome c
K3X53_12870	COG3391	amine dehydrogenase activity
K3X53_12875	COG1522	sequence-specific DNA binding
K3X53_12890	COG0535	radical SAM domain protein
K3X53_12905	COG2197	response regulator
K3X53_12915	COG1024	Enoyl-CoA hydratase
K3X53_12945	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
K3X53_12960	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
K3X53_12980	COG1766	The M ring may be actively involved in energy transduction
K3X53_12990	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
K3X53_12995	COG1338	Plays a role in the flagellum-specific transport system
K3X53_13000	COG4948	Mandelate Racemase Muconate Lactonizing
K3X53_13010	COG0583	DNA-binding transcription factor activity
K3X53_13015	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
K3X53_13030	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
K3X53_13035	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
K3X53_13035	COG0517	IMP dehydrogenase activity
K3X53_13035	COG0617	tRNA 3'-terminal CCA addition
K3X53_13045	COG5002	protein histidine kinase activity
K3X53_13045	COG2176	DNA-directed DNA polymerase activity
K3X53_13050	COG0243	molybdopterin cofactor binding
K3X53_13145	COG0183	Belongs to the thiolase family
K3X53_13185	COG1674	ftsk spoiiie
K3X53_13195	COG0154	amidase activity
K3X53_13200	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
K3X53_13210	COG2835	tetraacyldisaccharide 4'-kinase activity
K3X53_13225	COG0708	Exodeoxyribonuclease III
K3X53_13235	COG0789	Transcriptional regulator
K3X53_13245	COG0745	RESPONSE REGULATOR receiver
K3X53_13260	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
K3X53_13280	COG0495	leucyl-tRNA aminoacylation
K3X53_13295	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K3X53_13295	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
K3X53_13300	COG3264	Mechanosensitive ion channel
K3X53_13300	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
K3X53_13305	COG1024	Enoyl-CoA hydratase
K3X53_13310	COG4221	oxidoreductase activity
K3X53_13315	COG0312	modulator of DNA gyrase
K3X53_13320	COG0483	inositol monophosphate 1-phosphatase activity
K3X53_13325	COG1609	Transcriptional regulator
K3X53_13350	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
K3X53_13355	COG1917	Cupin 2, conserved barrel domain protein
K3X53_13360	COG0527	aspartate kinase activity
K3X53_13370	COG0006	proline dipeptidase activity
K3X53_13385	COG4166	transmembrane transport
K3X53_13390	COG0601	transmembrane transport
K3X53_13395	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K3X53_13405	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
K3X53_13410	COG1012	belongs to the aldehyde dehydrogenase family
K3X53_13415	COG1522	sequence-specific DNA binding
K3X53_13420	COG2423	ornithine cyclodeaminase activity
K3X53_13425	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
K3X53_13430	COG0006	proline dipeptidase activity
K3X53_13440	COG1802	Transcriptional regulator
K3X53_13485	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
K3X53_13490	COG0297	glycogen (starch) synthase activity
K3X53_13500	COG0438	transferase activity, transferring glycosyl groups
K3X53_13525	COG0438	transferase activity, transferring glycosyl groups
K3X53_13550	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
K3X53_13555	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K3X53_13575	COG0662	Cupin 2, conserved barrel domain protein
K3X53_13575	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
K3X53_13595	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
K3X53_13615	COG1194	a g-specific adenine glycosylase
K3X53_13625	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
K3X53_13630	COG3034	peptidoglycan biosynthetic process
K3X53_13635	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
K3X53_13640	COG0617	tRNA 3'-terminal CCA addition
K3X53_13645	COG0494	nUDIX hydrolase
K3X53_13655	COG0745	RESPONSE REGULATOR receiver
K3X53_13665	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
K3X53_13675	COG0137	argininosuccinate synthase activity
K3X53_13690	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K3X53_13695	COG0473	3-isopropylmalate dehydrogenase activity
K3X53_13710	COG0435	Glutathione S-transferase
K3X53_13715	COG0281	malic enzyme
K3X53_13715	COG0280	phosphate acetyltransferase
K3X53_13720	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
K3X53_13725	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
K3X53_13730	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
K3X53_13735	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
K3X53_13740	COG1420	regulation of RNA biosynthetic process
K3X53_13745	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
K3X53_13750	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
K3X53_13755	COG0635	Involved in the biosynthesis of porphyrin-containing compound
K3X53_13770	COG0357	Ribosomal RNA small subunit methyltransferase G
K3X53_13775	COG0445	tRNA wobble uridine modification
K3X53_13780	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
K3X53_13785	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
K3X53_13790	COG1981	membrane
K3X53_13795	COG0424	maF-like protein
K3X53_13800	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
K3X53_13805	COG0237	dephospho-CoA kinase activity
K3X53_13810	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
K3X53_13820	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
K3X53_13825	COG3030	protein affecting phage T7 exclusion by the F plasmid
K3X53_13850	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
K3X53_13855	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
K3X53_13870	COG1040	competence protein
K3X53_13880	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
K3X53_13895	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
K3X53_13915	COG0779	Required for maturation of 30S ribosomal subunits
K3X53_13930	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
K3X53_13940	COG0494	nUDIX hydrolase
K3X53_13945	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
K3X53_13950	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
K3X53_13955	COG0653	protein targeting
K3X53_13965	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
K3X53_13970	COG2003	Belongs to the UPF0758 family
K3X53_13975	COG0484	heat shock protein binding
K3X53_13980	COG0443	Heat shock 70 kDa protein
K3X53_14000	COG1218	3'(2'),5'-bisphosphate nucleotidase
K3X53_14005	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
K3X53_14035	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
K3X53_14040	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
K3X53_14045	COG1137	ATPase activity
K3X53_14065	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
K3X53_14075	COG0437	4 iron, 4 sulfur cluster binding
K3X53_14080	COG0243	molybdopterin cofactor binding
K3X53_14085	COG0657	acetylesterase activity
K3X53_14095	COG1663	tetraacyldisaccharide 4'-kinase activity
K3X53_14120	COG0714	Associated with various cellular activities
K3X53_14140	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K3X53_14155	COG2226	methyltransferase
K3X53_14170	COG4263	nitrous-oxide reductase activity
K3X53_14195	COG0437	4 iron, 4 sulfur cluster binding
K3X53_14200	COG0348	domain, Protein
K3X53_14225	COG1999	signal sequence binding
K3X53_14250	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
K3X53_14255	COG3178	'Phosphotransferase
K3X53_14260	COG0802	atpase or kinase
K3X53_14275	COG1999	signal sequence binding
K3X53_14280	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
K3X53_14295	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
K3X53_14305	COG1442	glycosyl transferase family 8
K3X53_14305	COG1216	Glycosyl transferase, family 2
K3X53_14315	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
K3X53_14320	COG0133	tryptophan synthase activity
K3X53_14325	COG1652	LysM domain
K3X53_14350	COG2350	Protein conserved in bacteria
K3X53_14355	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
K3X53_14360	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
K3X53_14380	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
K3X53_14405	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
K3X53_14425	COG5598	trimethylamine methyltransferase
K3X53_14430	COG1902	pentaerythritol trinitrate reductase activity
K3X53_14430	COG0446	pyridine nucleotide-disulphide oxidoreductase
K3X53_14435	COG0446	pyridine nucleotide-disulphide oxidoreductase
K3X53_14435	COG1902	pentaerythritol trinitrate reductase activity
K3X53_14440	COG0129	dihydroxy-acid dehydratase activity
K3X53_14450	COG2175	clavaminate synthase activity
K3X53_14470	COG3243	poly(R)-hydroxyalkanoic acid synthase
K3X53_14485	COG1228	amidohydrolase
K3X53_14490	COG2986	histidine ammonia-lyase
K3X53_14505	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
K3X53_14515	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
K3X53_14530	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
K3X53_14535	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
K3X53_14540	COG2808	Putative FMN-binding domain
K3X53_14585	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
K3X53_14600	COG1028	Short-chain dehydrogenase reductase Sdr
K3X53_14605	COG0697	spore germination
K3X53_14610	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
K3X53_14615	COG1418	mRNA catabolic process
K3X53_14635	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
K3X53_14640	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
K3X53_14650	COG1960	acyl-CoA dehydrogenase activity
K3X53_14680	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
K3X53_14685	COG0142	geranyltranstransferase activity
K3X53_14690	COG1722	exodeoxyribonuclease VII activity
K3X53_14695	COG0123	including yeast histone deacetylase and acetoin utilization protein
K3X53_14705	COG0745	RESPONSE REGULATOR receiver
K3X53_14710	COG1846	Transcriptional regulator
K3X53_14715	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
K3X53_14735	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
K3X53_14745	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
K3X53_14765	COG1968	undecaprenyl-diphosphatase activity
K3X53_14780	COG0564	pseudouridine synthase activity
K3X53_14825	COG0179	Fumarylacetoacetate (FAA) hydrolase
K3X53_14835	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
K3X53_14840	COG1360	Flagellar Motor Protein
K3X53_14845	COG4786	Flagellar basal body rod
K3X53_14860	COG1706	bacterial-type flagellum-dependent cell motility
K3X53_14870	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
K3X53_14880	COG4786	Flagellar basal body rod
K3X53_14885	COG4786	Flagellar basal body rod
K3X53_14890	COG1987	bacterial-type flagellum assembly
K3X53_14895	COG1677	Flagellar hook-basal body complex protein FliE
K3X53_14900	COG1558	bacterial-type flagellum-dependent cell motility
K3X53_14950	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
K3X53_14960	COG2226	methyltransferase
K3X53_14970	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
K3X53_14975	COG1024	Enoyl-CoA hydratase
K3X53_14980	COG0268	Binds directly to 16S ribosomal RNA
K3X53_14995	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
K3X53_15000	COG4134	Bacterial extracellular solute-binding protein
K3X53_15005	COG4135	transport system, permease component
K3X53_15010	COG4136	ATPase activity
K3X53_15015	COG1122	ATPase activity
K3X53_15020	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
K3X53_15025	COG1268	BioY protein
K3X53_15030	COG2351	hydroxyisourate hydrolase activity
K3X53_15035	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
K3X53_15060	COG1473	amidohydrolase
K3X53_15065	COG1522	sequence-specific DNA binding
K3X53_15070	COG2226	methyltransferase
K3X53_15080	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
K3X53_15080	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
K3X53_15085	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
K3X53_15090	COG0156	8-amino-7-oxononanoate synthase activity
K3X53_15095	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
K3X53_15105	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
K3X53_15105	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
K3X53_15105	COG0506	proline dehydrogenase activity
K3X53_15110	COG1522	sequence-specific DNA binding
K3X53_15115	COG1049	propionate catabolic process, 2-methylcitrate cycle
K3X53_15125	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
K3X53_15140	COG1183	phosphatidylcholine synthase activity
K3X53_15150	COG0310	cobalt ion transport
K3X53_15155	COG0310	cobalt ion transport
K3X53_15160	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
K3X53_15165	COG1122	ATPase activity
K3X53_15175	COG0174	glutamine synthetase
K3X53_15180	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K3X53_15185	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K3X53_15190	COG3800	Transcriptional regulator
K3X53_15190	COG1396	sequence-specific DNA binding
K3X53_15195	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
K3X53_15200	COG1960	acyl-CoA dehydrogenase activity
K3X53_15205	COG1012	belongs to the aldehyde dehydrogenase family
K3X53_15210	COG4566	intracellular signal transduction
K3X53_15220	COG2358	TRAP transporter, solute receptor (TAXI family
K3X53_15260	COG0395	ABC-type sugar transport system, permease component
K3X53_15265	COG1175	transmembrane transport
K3X53_15270	COG3842	ATPase activity
K3X53_15275	COG3842	ATPase activity
K3X53_15355	COG0134	indole-3-glycerol-phosphate synthase activity
K3X53_15360	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
K3X53_15365	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
K3X53_15370	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
K3X53_15375	COG1960	acyl-CoA dehydrogenase activity
K3X53_15390	COG0662	Cupin 2, conserved barrel domain protein
K3X53_15400	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K3X53_15400	COG4191	Histidine kinase
K3X53_15415	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
K3X53_15425	COG1136	(ABC) transporter
K3X53_15435	COG0745	RESPONSE REGULATOR receiver
K3X53_15445	COG1280	lysine exporter protein (LysE YggA)
K3X53_15490	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
K3X53_15500	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
K3X53_15525	COG1450	Type ii and iii secretion system protein
K3X53_15610	COG0587	DNA-directed DNA polymerase activity
K3X53_15625	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
K3X53_15695	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
K3X53_15695	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
K3X53_15705	COG2132	Multicopper oxidase
K3X53_15710	COG2010	Cytochrome c
K3X53_15710	COG1529	Aldehyde oxidase and xanthine dehydrogenase
K3X53_15755	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
K3X53_15760	COG1376	ErfK ybiS ycfS ynhG family protein
K3X53_15765	COG4235	cytochrome complex assembly
K3X53_15770	COG3088	subunit of a heme lyase
K3X53_15775	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K3X53_15780	COG1138	Cytochrome C-type biogenesis protein
K3X53_15810	COG0398	Pfam SNARE associated Golgi protein
K3X53_15820	COG1230	cation diffusion facilitator family transporter
K3X53_15855	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
K3X53_15890	COG1215	transferase activity, transferring glycosyl groups
K3X53_15905	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
K3X53_15915	COG0698	ribose 5-phosphate isomerase
K3X53_15925	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
K3X53_15935	COG0729	surface antigen
K3X53_15950	COG0010	Belongs to the arginase family
K3X53_15960	COG2183	response to ionizing radiation
K3X53_15970	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
K3X53_15990	COG3842	ATPase activity
K3X53_16005	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
K3X53_16010	COG4149	molybdate abc transporter
K3X53_16015	COG0725	ABC transporter, periplasmic molybdate-binding protein
K3X53_16040	COG1115	amino acid carrier protein
K3X53_16050	COG0404	The glycine cleavage system catalyzes the degradation of glycine
K3X53_16055	COG0509	glycine decarboxylation via glycine cleavage system
K3X53_16060	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
K3X53_16060	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor